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class="vector-dropdown " title="Sayfanın yazı tipi boyutunun, genişliğinin ve renginin görünümünü değiştirin" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Görünüm" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Görünüm</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_tr.wikipedia.org&uselang=tr" class=""><span>Bağış yapın</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%C3%96zel:HesapOlu%C5%9Ftur&returnto=%C3%9Cre+d%C3%B6ng%C3%BCs%C3%BC&returntoquery=action%3Dedit" title="Bir hesap oluşturup oturum açmanız tavsiye edilmektedir ancak bu zorunlu değildir" class=""><span>Hesap oluştur</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%C3%96zel:Kullan%C4%B1c%C4%B1OturumuA%C3%A7ma&returnto=%C3%9Cre+d%C3%B6ng%C3%BCs%C3%BC&returntoquery=action%3Dedit" title="Oturum açmanız tavsiye edilmektedir; ancak bu zorunlu değildir [o]" accesskey="o" class=""><span>Oturum aç</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Daha fazla seçenek" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Kişisel araçlar" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span 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mw-ui-icon-wikimedia-userAdd"></span> <span>Hesap oluştur</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%C3%96zel:Kullan%C4%B1c%C4%B1OturumuA%C3%A7ma&returnto=%C3%9Cre+d%C3%B6ng%C3%BCs%C3%BC&returntoquery=action%3Dedit" title="Oturum açmanız tavsiye edilmektedir; ancak bu zorunlu değildir [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Oturum aç</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Çıkış yapmış editörler için sayfalar <a href="/wiki/Yard%C4%B1m:Giri%C5%9F" aria-label="Değişiklik yapma hakkında daha fazla bilgi edinin"><span>daha fazla bilgi</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/%C3%96zel:Katk%C4%B1lar%C4%B1m" title="Bu IP adresinden yapılmış değişiklikler listesi [y]" accesskey="y"><span>Katkılar</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/%C3%96zel:MesajSayfam" title="Bu IP adresindeki düzenlemeler hakkında tartışma [n]" accesskey="n"><span>Mesaj</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <h1 id="firstHeading" class="firstHeading mw-first-heading">Üre döngüsü sayfasının kaynağını 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Ayrıca, yukarıdaki tüm ayrıntıları içeren bir e-postayı <a href="https://meta.wikimedia.org/wiki/Special:MyLanguage/Stewards" class="extiw" title="m:Special:MyLanguage/Stewards">kahyalar</a> <a href="https://meta.wikimedia.org/wiki/Special:MyLanguage/VRT" class="extiw" title="m:Special:MyLanguage/VRT">VRT</a> sırasına <kbd>stewards@wikimedia.org</kbd> adresinden gönderebilirsiniz.</div></div><hr /> <p>Bu sayfanın kaynağını görebilir ve kopyalayabilirsiniz. </p><textarea readonly="" accesskey="," id="wpTextbox1" cols="80" rows="25" style="" class="mw-editfont-monospace" lang="tr" dir="ltr" name="wpTextbox1">[[Dosya:Urea_cycle_2.png|küçükresim|upright=2.05|<div style="border-width: 0px; border-bottom: 1px solid black; text-align: left;">'''Üre döngüsü reaksiyonları'''.</div>Şemadaki Üre döngüsünün elemanları şu şekilde renklendirilmiştir: <span style="font-weight: bold;"><span style="color: blue;">enzimler</span>, <span style="color: rgb(219,155,36);">koenzimler</span>, <span style="color: rgb(151,149,45);">substratlar</span>, <span style="color: rgb(128,0,0);">inorganik moleküller</span>, <span style="color: red;">Asp ve ondan üreye aktarılan nitrojen</span>, <span style="color: green;">NH<sub>4</sub><sup>+</sup> ve ondan üreye aktarılan nitrojen</span>, <span style="color: rgb(125,125,233);">HCO<sub>3</sub><sup>-</sup> ve ondan üreye aktarılan karbon atomu</span> </span>]] '''Üre Döngüsü''' karaciğerde gerçekleşir ve toksik bir madde olan amonyağın daha az toksik bir madde olan üreye çevrilmesini sağlar. Daha sonra üre kana verilerek böbreğe gönderilir, oradan da idrar ile vücuttan atılır. Mitokondri ve sitoplazma evresi olmak üzere iki evreden oluşur. == Mitokondri evresi == Karaciğer hücrelerinin mitokondri matrikslerinde gerçekleşen bu evrede ilk olarak oksidatif deaminasyon sonucu oluşmuş olan [[amonyak]],aktif karbondioksit ve 2 adet [[Adenozin trifosfat|ATP]] molekülüne de alarak ''Karbomoil Fosfat Sentaz I'' enziminin yardımıyla Karbomoil Fosfat oluşturur. Burada dikkat edilecek nokta, bu enzim N-Asetil Glutamat olmadan işlev görememektedir. Daha sonra oluşan Karbomoil Fosfat, protein sentezinde kullanılmayan bir aminoasit olan Ornitin ile Ornitin Transkarbomoilaz enzimiyle reaksiyona girerek protein sentezine girmeyen diğer bir aminoasit olan Sitrülin'e çevrilir. Sitrülin ise sitoplazmaya taşınır. Ve bu noktada Mitokondri evresi sonlanır. == Özet == #Amaç toksik amonyağın daha az toksik olan üre dönüştürülmesidir. #Arginaz enzimi yalnızca karaciğerde bulunduğu için bu döngü karaciğerde gerçekleşir. #Toplam 3 ATP harcanır ancak 4 yüksek enerjili fosfat bağı kopar, yani 2 ADP ve 1 AMP açığa çıkar. #Ürede 2 azot bulunur ve bunlar oksidatif deaminasyon sonucu oluşan serbest amonyak ve transaminasyon sonucu oluşan aspartattan sağlanır. == Kaynakça == Lippincott Illustrated Reviews Biochemistry [[Kategori:Biyokimya]] </textarea><div class="templatesUsed"></div><p id="mw-returnto"><a href="/wiki/%C3%9Cre_d%C3%B6ng%C3%BCs%C3%BC" title="Üre döngüsü">Üre döngüsü</a> sayfasına geri dön.</p> <noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">"<a dir="ltr" href="https://tr.wikipedia.org/wiki/Üre_döngüsü">https://tr.wikipedia.org/wiki/Üre_döngüsü</a>" sayfasından alınmıştır</div></div> <div id="catlinks" class="catlinks catlinks-allhidden" data-mw="interface"></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Gizlilik politikası</a></li> <li id="footer-places-about"><a href="/wiki/Vikipedi:Hakk%C4%B1nda">Vikipedi hakkında</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Vikipedi:Genel_sorumluluk_reddi">Sorumluluk reddi</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Davranış Kuralları</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Geliştiriciler</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/tr.wikipedia.org">İstatistikler</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Çerez politikası</a></li> <li id="footer-places-mobileview"><a href="//tr.m.wikipedia.org/w/index.php?title=%C3%9Cre_d%C3%B6ng%C3%BCs%C3%BC&action=edit&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobil görünüm</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-f69cdc8f6-xvj4r","wgBackendResponseTime":170,"wgPageParseReport":{"limitreport":{"cputime":"0.004","walltime":"0.005","ppvisitednodes":{"value":17,"limit":1000000},"postexpandincludesize":{"value":768,"limit":2097152},"templateargumentsize":{"value":0,"limit":2097152},"expansiondepth":{"value":2,"limit":100},"expensivefunctioncount":{"value":0,"limit":500},"unstrip-depth":{"value":0,"limit":20},"unstrip-size":{"value":0,"limit":5000000},"entityaccesscount":{"value":0,"limit":400},"timingprofile":["100.00% 0.000 1 -total"]},"cachereport":{"origin":"mw-web.codfw.main-f69cdc8f6-xvj4r","timestamp":"20241124114512","ttl":2592000,"transientcontent":false}}});});</script> </body> </html>