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</div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ADAM15</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/193">ADAM15</a></span>, MDC15, ADAM metallopeptidase domain 15</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/605548">605548</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1333882">1333882</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2829">2829</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAM15">ADAM15</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000143537">ADAM15 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/450px-Ideogram_human_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/600px-Ideogram_human_chromosome_1.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_1_(human)" class="mw-redirect" title="Chromosome 1 (human)">Chromosome 1 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_1_ideogram.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/300px-Human_chromosome_1_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/450px-Human_chromosome_1_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/600px-Human_chromosome_1_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 177.79396747882px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ADAM15"><img alt="Genomic location for ADAM15" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 183.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ADAM15"><img alt="Genomic location for ADAM15" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1q21.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">155,050,566 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">155,062,775 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/390px-Ideogram_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/520px-Ideogram_house_mouse_chromosome_3.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 3 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/300px-Ideogram_of_house_mouse_chromosome_3.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/450px-Ideogram_of_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/600px-Ideogram_of_house_mouse_chromosome_3.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 158.63339255567px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ADAM15"><img alt="Genomic location for ADAM15" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 164.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ADAM15"><img alt="Genomic location for ADAM15" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3 F1|3 39.07 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">89,245,849 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">89,257,303 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000143537">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">skin of leg</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">apex of heart</li><br /><li style="line-height: 137%;">tibial nerve</li><br /><li style="line-height: 137%;">left uterine tube</li><br /><li style="line-height: 137%;">gastric mucosa</li><br /><li style="line-height: 137%;">minor salivary glands</li><br /><li style="line-height: 137%;">upper lobe of left lung</li><br /><li style="line-height: 137%;">right lung</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000028041">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">superior frontal gyrus</li><br /><li style="line-height: 137%;">gastrula</li><br /><li style="line-height: 137%;">gallbladder</li><br /><li style="line-height: 137%;">superior surface of tongue</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br /><li style="line-height: 137%;">primary visual cortex</li><br /><li style="line-height: 137%;">esophagus</li><br /><li style="line-height: 137%;">muscle of thigh</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000143537">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ADAM15_217007_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_ADAM15_217007_s_at_fs.png/250px-PBB_GE_ADAM15_217007_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_ADAM15_217007_s_at_fs.png/375px-PBB_GE_ADAM15_217007_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_ADAM15_217007_s_at_fs.png/500px-PBB_GE_ADAM15_217007_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/8751/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017124">SH3 domain binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005178">integrin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008233">peptidase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008237">metallopeptidase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004222">metalloendopeptidase activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005912">adherens junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001669">acrosomal vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031410">cytoplasmic vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0012505">endomembrane system</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031514">motile cilium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005929">cilium</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008584">male gonad development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900121">negative regulation of receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042246">tissue regeneration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0022617">extracellular matrix disassembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006508">proteolysis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001953">negative regulation of cell-matrix adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030336">negative regulation of cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030308">negative regulation of cell growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030574">collagen catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007229">integrin-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007160">cell-matrix adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045087">innate immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060317">cardiac epithelial to mesenchymal transition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006915">apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030198">extracellular matrix organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002418">immune response to tumor cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904628">cellular response to phorbol 13-acetate 12-myristate</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990910">response to hypobaric hypoxia</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=8751&rn=1">8751</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11490&rn=1">11490</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000143537;db=core">ENSG00000143537</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000028041;db=core">ENSMUSG00000028041</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q13444">Q13444</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O88839">O88839</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001261464">NM_001261464</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001261465">NM_001261465</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001261466">NM_001261466</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_003815">NM_003815</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_207191">NM_207191</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_207194">NM_207194</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_207195">NM_207195</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_207196">NM_207196</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_207197">NM_207197</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001037722">NM_001037722</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009614">NM_009614</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001248393">NP_001248393</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001248394">NP_001248394</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001248395">NP_001248395</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_003806">NP_003806</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_997074">NP_997074</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_997077">NP_997077</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_997078">NP_997078</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_997079">NP_997079</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_997080">NP_997080</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001032811">NP_001032811</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033744">NP_033744</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr1:155050566-155062775">Chr 1: 155.05 – 155.06 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr3:89245849-89257303">Chr 3: 89.25 – 89.26 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18033305" class="extiw" title="d:Q18033305">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18247404" class="extiw" title="d:Q18247404">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Disintegrin and metalloproteinase domain-containing protein 15</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>ADAM15</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9516430_5-0" class="reference"><a href="#cite_note-pmid9516430-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The protein encoded by this gene is a member of the <a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM</a> (a disintegrin and metalloproteinase) protein family. ADAM family members are type I <a href="/wiki/Transmembrane" class="mw-redirect" title="Transmembrane">transmembrane</a> <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoproteins</a> known to be involved in <a href="/wiki/Cell_adhesion" title="Cell adhesion">cell adhesion</a> and proteolytic <a href="/wiki/Ectodomain" title="Ectodomain">ectodomain</a> processing of <a href="/wiki/Cytokine" title="Cytokine">cytokines</a> and <a href="/wiki/Adhesion_molecule" class="mw-redirect" title="Adhesion molecule">adhesion molecules</a>. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a <a href="/wiki/Disintegrin" title="Disintegrin">disintegrin</a>-like domain, as well as an <a href="/wiki/EGF-like_domain" title="EGF-like domain">EGF-like domain</a>. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, <a href="/wiki/CD61" class="mw-redirect" title="CD61">beta 3</a>. It also interacts with <a href="/wiki/Tyrosine-protein_kinase_CSK" title="Tyrosine-protein kinase CSK">Src</a> family protein-tyrosine kinases in a <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a>-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.<sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=2" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Arthritis">Arthritis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=3" title="Edit section: Arthritis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ADAM15 has been associated with a number of diseases, most recently <a href="/wiki/Rheumatoid_Arthritis" class="mw-redirect" title="Rheumatoid Arthritis">Rheumatoid Arthritis</a> where it is required for the activation of the <a href="/wiki/PTK2" title="PTK2">FAK</a> and <a href="/wiki/Proto-oncogene_tyrosine-protein_kinase_Src" title="Proto-oncogene tyrosine-protein kinase Src">Src</a> pathways to generate apoptosis resistance in response to apoptotic signalling or cell stress.<sup id="cite_ref-pmid23918525_7-0" class="reference"><a href="#cite_note-pmid23918525-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> ADAM15 also has an antiapoptotic effect in <a href="/wiki/Osteoarthritis" title="Osteoarthritis">osteoarthritic</a> <a href="/wiki/Chondrocyte" title="Chondrocyte">chondrocytes</a>.<sup id="cite_ref-pmid20213810_8-0" class="reference"><a href="#cite_note-pmid20213810-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=4" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The precise role of ADAM15 in cancer is still unclear but the metalloprotein has been linked to a number of different cancerous diseases such as <a href="/wiki/Breast_cancer" title="Breast cancer">Breast cancer</a> where the expression of the protein is increased in carcinoma in-situ, invasive carcinoma and metastatic breast cancer tissues<sup id="cite_ref-Rainer_9-0" class="reference"><a href="#cite_note-Rainer-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Additionally, the alternative splice variant forms of ADAM15 have also been correlated with different prognosis in 48 breast cancer patients based upon their expression levels.<sup id="cite_ref-Zhong_10-0" class="reference"><a href="#cite_note-Zhong-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> ADAM15 has also been shown to have a role in <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> again through increased expression in neoplastic and metastatic tissues compared to normal prostate tissues<sup id="cite_ref-Rainer_9-1" class="reference"><a href="#cite_note-Rainer-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> and also through its modulation of <a href="/wiki/Epithelium" title="Epithelium">epithelial</a> cell- tumour cell interactions.<sup id="cite_ref-pmid18281484_11-0" class="reference"><a href="#cite_note-pmid18281484-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=5" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ADAM15 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <ul><li><a href="/wiki/Grb2" class="mw-redirect" title="Grb2">Grb2</a>,<sup id="cite_ref-pmid11741929_12-0" class="reference"><a href="#cite_note-pmid11741929-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HCK" title="HCK">HCK</a>,<sup id="cite_ref-pmid11741929_12-1" class="reference"><a href="#cite_note-pmid11741929-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Lck" class="mw-redirect" title="Lck">Lck</a><sup id="cite_ref-pmid11741929_12-2" class="reference"><a href="#cite_note-pmid11741929-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/SH3GL2" title="SH3GL2">SH3GL2</a>,<sup id="cite_ref-pmid10531379_13-0" class="reference"><a href="#cite_note-pmid10531379-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/SNX9" title="SNX9">SNX9</a>.<sup id="cite_ref-pmid10531379_13-1" class="reference"><a href="#cite_note-pmid10531379-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li></ul> <p>The alternatively spliced isoforms have also been shown to exhibit different preferential interactions with proteins containing <a href="/wiki/SH3_domain" title="SH3 domain">SH3 domains</a>.<sup id="cite_ref-Zhong_10-1" class="reference"><a href="#cite_note-Zhong-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19718658_14-0" class="reference"><a href="#cite_note-pmid19718658-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 35em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000143537">GRCh38: Ensembl release 89: ENSG00000143537</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000028041">GRCm38: Ensembl release 89: ENSMUSG00000028041</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arthritis+Rheum.&rft.atitle=ADAM15+adds+to+apoptosis+resistance+of+synovial+fibroblasts+by+modulating+focal+adhesion+kinase+signaling&rft.volume=65&rft.issue=11&rft.pages=2826-34&rft.date=2013-11&rft_id=info%3Adoi%2F10.1002%2Fart.38109&rft_id=info%3Apmid%2F23918525&rft.aulast=B%C3%B6hm&rft.aufirst=BB&rft.au=Freund%2C+I&rft.au=Krause%2C+K&rft.au=Kinne%2C+RW&rft.au=Burkhardt%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fart.38109&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-pmid20213810-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20213810_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBöhmHessKrauseSchirner2010" class="citation journal cs1">Böhm B, Hess S, Krause K, Schirner A, Ewald W, Aigner T, Burkhardt H 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"ADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis". <i>Arthritis Rheum</i>. <b>62</b> (5): 1372–82. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fart.27387">10.1002/art.27387</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20213810">20213810</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arthritis+Rheum.&rft.atitle=ADAM15+exerts+an+antiapoptotic+effect+on+osteoarthritic+chondrocytes+via+up-regulation+of+the+X-linked+inhibitor+of+apoptosis&rft.volume=62&rft.issue=5&rft.pages=1372-82&rft.date=2010-05&rft_id=info%3Adoi%2F10.1002%2Fart.27387&rft_id=info%3Apmid%2F20213810&rft.aulast=B%C3%B6hm&rft.aufirst=B&rft.au=Hess%2C+S&rft.au=Krause%2C+K&rft.au=Schirner%2C+A&rft.au=Ewald%2C+W&rft.au=Aigner%2C+T&rft.au=Burkhardt%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-Rainer-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-Rainer_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Rainer_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKueferDayKleerSabel2006" class="citation journal cs1">Kuefer R, Day KC, Kleer CG, Sabel MS, Hofer MD, Varambally S, Zorn CS, Chinnaiyan AM, Rubin MA, Day ML (April 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1600681">"ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease"</a>. <i>Neoplasia</i>. <b>8</b> (4): 319–29. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1593%2Fneo.05682">10.1593/neo.05682</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1600681">1600681</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16756724">16756724</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neoplasia&rft.atitle=ADAM15+disintegrin+is+associated+with+aggressive+prostate+and+breast+cancer+disease&rft.volume=8&rft.issue=4&rft.pages=319-29&rft.date=2006-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1600681%23id-name%3DPMC&rft_id=info%3Apmid%2F16756724&rft_id=info%3Adoi%2F10.1593%2Fneo.05682&rft.aulast=Kuefer&rft.aufirst=R&rft.au=Day%2C+KC&rft.au=Kleer%2C+CG&rft.au=Sabel%2C+MS&rft.au=Hofer%2C+MD&rft.au=Varambally%2C+S&rft.au=Zorn%2C+CS&rft.au=Chinnaiyan%2C+AM&rft.au=Rubin%2C+MA&rft.au=Day%2C+ML&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1600681&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-Zhong-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-Zhong_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Zhong_10-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhongPoghosyanPenningtonScott2008" class="citation journal cs1">Zhong JL, Poghosyan Z, Pennington CJ, Scott X, Handsley MM, Warn A, Gavrilovic J, Honert K, Krüger A, Span PN, Sweep FC, Edwards DR (March 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F1541-7786.MCR-07-2028">"Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma"</a>. <i>Mol. Cancer Res</i>. <b>6</b> (3): 383–94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F1541-7786.MCR-07-2028">10.1158/1541-7786.MCR-07-2028</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18296648">18296648</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cancer+Res.&rft.atitle=Distinct+functions+of+natural+ADAM-15+cytoplasmic+domain+variants+in+human+mammary+carcinoma&rft.volume=6&rft.issue=3&rft.pages=383-94&rft.date=2008-03&rft_id=info%3Adoi%2F10.1158%2F1541-7786.MCR-07-2028&rft_id=info%3Apmid%2F18296648&rft.aulast=Zhong&rft.aufirst=JL&rft.au=Poghosyan%2C+Z&rft.au=Pennington%2C+CJ&rft.au=Scott%2C+X&rft.au=Handsley%2C+MM&rft.au=Warn%2C+A&rft.au=Gavrilovic%2C+J&rft.au=Honert%2C+K&rft.au=Kr%C3%BCger%2C+A&rft.au=Span%2C+PN&rft.au=Sweep%2C+FC&rft.au=Edwards%2C+DR&rft_id=https%3A%2F%2Fdoi.org%2F10.1158%252F1541-7786.MCR-07-2028&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-pmid18281484-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid18281484_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNajyDayDay2008" class="citation journal cs1">Najy AJ, Day KC, Day ML (February 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F0008-5472.CAN-07-2432">"ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction"</a>. <i>Cancer Res</i>. <b>68</b> (4): 1092–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F0008-5472.CAN-07-2432">10.1158/0008-5472.CAN-07-2432</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18281484">18281484</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Res.&rft.atitle=ADAM15+supports+prostate+cancer+metastasis+by+modulating+tumor+cell-endothelial+cell+interaction&rft.volume=68&rft.issue=4&rft.pages=1092-9&rft.date=2008-02&rft_id=info%3Adoi%2F10.1158%2F0008-5472.CAN-07-2432&rft_id=info%3Apmid%2F18281484&rft.aulast=Najy&rft.aufirst=AJ&rft.au=Day%2C+KC&rft.au=Day%2C+ML&rft_id=https%3A%2F%2Fdoi.org%2F10.1158%252F0008-5472.CAN-07-2432&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-pmid11741929-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid11741929_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid11741929_12-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid11741929_12-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPoghosyanRobbinsHouslayWebster2002" class="citation journal cs1">Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR (February 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M107430200">"Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases"</a>. <i>J. 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Chem</i>. <b>277</b> (7): 4999–5007. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M107430200">10.1074/jbc.M107430200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11741929">11741929</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Phosphorylation-dependent+interactions+between+ADAM15+cytoplasmic+domain+and+Src+family+protein-tyrosine+kinases&rft.volume=277&rft.issue=7&rft.pages=4999-5007&rft.date=2002-02&rft_id=info%3Adoi%2F10.1074%2Fjbc.M107430200&rft_id=info%3Apmid%2F11741929&rft.aulast=Poghosyan&rft.aufirst=Z&rft.au=Robbins%2C+SM&rft.au=Houslay%2C+MD&rft.au=Webster%2C+A&rft.au=Murphy%2C+G&rft.au=Edwards%2C+DR&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M107430200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-pmid10531379-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid10531379_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid10531379_13-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHowardNelsonMaciewiczBlobel1999" class="citation journal cs1">Howard L, Nelson KK, Maciewicz RA, Blobel CP (October 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.44.31693">"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1"</a>. <i>J. 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Chem</i>. <b>274</b> (44): 31693–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.44.31693">10.1074/jbc.274.44.31693</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10531379">10531379</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Interaction+of+the+metalloprotease+disintegrins+MDC9+and+MDC15+with+two+SH3+domain-containing+proteins%2C+endophilin+I+and+SH3PX1&rft.volume=274&rft.issue=44&rft.pages=31693-9&rft.date=1999-10&rft_id=info%3Adoi%2F10.1074%2Fjbc.274.44.31693&rft_id=info%3Apmid%2F10531379&rft.aulast=Howard&rft.aufirst=L&rft.au=Nelson%2C+KK&rft.au=Maciewicz%2C+RA&rft.au=Blobel%2C+CP&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.274.44.31693&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> <li id="cite_note-pmid19718658-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19718658_14-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKleinoOrtizYritysHuovila2009" class="citation journal cs1">Kleino I, Ortiz RM, Yritys M, Huovila AP, Saksela K (November 2009). 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Biochem</i>. <b>108</b> (4): 877–85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjcb.22317">10.1002/jcb.22317</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19718658">19718658</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25997734">25997734</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell.+Biochem.&rft.atitle=Alternative+splicing+of+ADAM15+regulates+its+interactions+with+cellular+SH3+proteins&rft.volume=108&rft.issue=4&rft.pages=877-85&rft.date=2009-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25997734%23id-name%3DS2CID&rft_id=info%3Apmid%2F19718658&rft_id=info%3Adoi%2F10.1002%2Fjcb.22317&rft.aulast=Kleino&rft.aufirst=I&rft.au=Ortiz%2C+RM&rft.au=Yritys%2C+M&rft.au=Huovila%2C+AP&rft.au=Saksela%2C+K&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=7" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 35em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPrimakoffMyles2000" class="citation journal cs1">Primakoff P, Myles DG (2000). "The ADAM gene family: surface proteins with adhesion and protease activity". <i>Trends Genet</i>. <b>16</b> (2): 83–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0168-9525%2899%2901926-5">10.1016/S0168-9525(99)01926-5</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10652535">10652535</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Trends+Genet.&rft.atitle=The+ADAM+gene+family%3A+surface+proteins+with+adhesion+and+protease+activity.&rft.volume=16&rft.issue=2&rft.pages=83-7&rft.date=2000&rft_id=info%3Adoi%2F10.1016%2FS0168-9525%2899%2901926-5&rft_id=info%3Apmid%2F10652535&rft.aulast=Primakoff&rft.aufirst=P&rft.au=Myles%2C+DG&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTakagi_J2002" class="citation journal cs1">Takagi J (2002). 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Cell Res</i>. <b>279</b> (2): 239–47. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fexcr.2002.5606">10.1006/excr.2002.5606</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12243749">12243749</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Exp.+Cell+Res.&rft.atitle=ADAM15+is+an+adherens+junction+molecule+whose+surface+expression+can+be+driven+by+VE-cadherin&rft.volume=279&rft.issue=2&rft.pages=239-47&rft.date=2002&rft_id=info%3Adoi%2F10.1006%2Fexcr.2002.5606&rft_id=info%3Apmid%2F12243749&rft.aulast=Ham&rft.aufirst=C&rft.au=Levkau%2C+B&rft.au=Raines%2C+EW&rft.au=Herren%2C+B&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStrausbergFeingoldGrouse2003" class="citation journal cs1">Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. <b>99</b> (26): 16899–903. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.atitle=Generation+and+initial+analysis+of+more+than+15%2C000+full-length+human+and+mouse+cDNA+sequences&rft.volume=99&rft.issue=26&rft.pages=16899-903&rft.date=2003&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC139241%23id-name%3DPMC&rft_id=info%3Apmid%2F12477932&rft_id=info%3Adoi%2F10.1073%2Fpnas.242603899&rft_id=info%3Abibcode%2F2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold%2C+EA&rft.au=Grouse%2C+LH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC139241&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAbramSealsPass2003" class="citation journal cs1">Abram CL, Seals DF, Pass I, et al. (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M300267200">"The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells"</a>. <i>J. Biol. Chem</i>. <b>278</b> (19): 16844–51. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M300267200">10.1074/jbc.M300267200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12615925">12615925</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=The+adaptor+protein+fish+associates+with+members+of+the+ADAMs+family+and+localizes+to+podosomes+of+Src-transformed+cells&rft.volume=278&rft.issue=19&rft.pages=16844-51&rft.date=2003&rft_id=info%3Adoi%2F10.1074%2Fjbc.M300267200&rft_id=info%3Apmid%2F12615925&rft.aulast=Abram&rft.aufirst=CL&rft.au=Seals%2C+DF&rft.au=Pass%2C+I&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M300267200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AADAM15" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ADAM15&action=edit&section=8" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>The <a href="/wiki/MEROPS" title="MEROPS">MEROPS</a> online database for peptidases and their inhibitors: <a rel="nofollow" class="external text" href="http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.215">M12.215</a></li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ADAM15"><i>ADAM15</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ADAM15"><i>ADAM15</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline 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href="/wiki/Template:Metalloendopeptidases" title="Template:Metalloendopeptidases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Metalloendopeptidases" title="Template talk:Metalloendopeptidases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Metalloendopeptidases" title="Special:EditPage/Template:Metalloendopeptidases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteases:_metalloendopeptidases_(EC_3.4.24)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protease" title="Protease">Proteases</a>: <a href="/wiki/Metalloendopeptidase" title="Metalloendopeptidase">metalloendopeptidases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.4.24:_Metallopeptidases" title="List of EC numbers (EC 3)">3.4.24</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha_secretase" title="Alpha secretase">Alpha secretases</a> <ul><li><a href="/wiki/ADAM9" title="ADAM9">ADAM9</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">ADAM10</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">ADAM17</a></li> <li><a href="/wiki/ADAM19" title="ADAM19">ADAM19</a></li></ul></li> <li><a href="/wiki/ADAM2" title="ADAM2">ADAM2</a></li> <li><a href="/wiki/ADAM7" title="ADAM7">ADAM7</a></li> <li><a href="/wiki/ADAM8" title="ADAM8">ADAM8</a></li> <li><a href="/wiki/ADAM11" title="ADAM11">ADAM11</a></li> <li><a href="/wiki/ADAM12" title="ADAM12">ADAM12</a></li> <li><a class="mw-selflink selflink">ADAM15</a></li> <li><a href="/wiki/ADAM18" title="ADAM18">ADAM18</a></li> <li><a href="/wiki/ADAM22" title="ADAM22">ADAM22</a></li> <li><a href="/wiki/ADAM23" title="ADAM23">ADAM23</a></li> <li><a href="/wiki/ADAM28" title="ADAM28">ADAM28</a></li> <li><a href="/wiki/ADAM33" title="ADAM33">ADAM33</a></li> <li><a href="/wiki/ADAMTS1" title="ADAMTS1">ADAMTS1</a></li> <li><a href="/wiki/ADAMTS2" title="ADAMTS2">ADAMTS2</a></li> <li><a href="/wiki/ADAMTS3" title="ADAMTS3">ADAMTS3</a></li> <li><a href="/wiki/ADAMTS4" title="ADAMTS4">ADAMTS4</a></li> <li><a href="/wiki/ADAMTS5" title="ADAMTS5">ADAMTS5</a></li> <li><a href="/wiki/ADAMTS8" title="ADAMTS8">ADAMTS8</a></li> <li><a href="/wiki/ADAMTS9" title="ADAMTS9">ADAMTS9</a></li> <li><a href="/wiki/ADAMTS10" title="ADAMTS10">ADAMTS10</a></li> <li><a href="/wiki/ADAMTS12" title="ADAMTS12">ADAMTS12</a></li> <li><a href="/wiki/ADAMTS13" title="ADAMTS13">ADAMTS13</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Matrix_metalloproteinase" title="Matrix metalloproteinase">Matrix metalloproteinases</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Collagenase" title="Collagenase">Collagenases</a> <ul><li><a href="/wiki/MMP1" class="mw-redirect" title="MMP1">MMP1</a></li> <li><a href="/wiki/MMP8" title="MMP8">MMP8</a></li></ul></li> <li><a href="/wiki/Gelatinase" title="Gelatinase">Gelatinases</a> <ul><li><a href="/wiki/MMP2" title="MMP2">MMP2</a></li> <li><a href="/wiki/MMP9" title="MMP9">MMP9</a></li></ul></li> <li><a href="/wiki/MMP3" title="MMP3">MMP3</a></li> <li><a href="/wiki/MMP7" title="MMP7">MMP7</a></li> <li><a href="/wiki/MMP10" title="MMP10">MMP10</a></li> <li><a href="/wiki/MMP11" title="MMP11">MMP11</a></li> <li><a href="/wiki/Matrix_metallopeptidase_12" title="Matrix metallopeptidase 12">MMP12</a></li> <li><a href="/wiki/Matrix_metallopeptidase_13" title="Matrix metallopeptidase 13">MMP13</a></li> <li><a href="/wiki/MMP14" title="MMP14">MMP14</a></li> <li><a href="/wiki/MMP15" title="MMP15">MMP15</a></li> <li><a href="/wiki/MMP16" title="MMP16">MMP16</a></li> <li><a href="/wiki/MMP17" title="MMP17">MMP17</a></li> <li><a href="/wiki/MMP19" title="MMP19">MMP19</a></li> <li><a href="/wiki/MMP20" title="MMP20">MMP20</a></li> <li><a href="/wiki/MMP21" title="MMP21">MMP21</a></li> <li><a href="/w/index.php?title=MMP23A&action=edit&redlink=1" class="new" title="MMP23A (page does not exist)">MMP23A</a></li> <li><a href="/wiki/MMP23B" title="MMP23B">MMP23B</a></li> <li><a href="/wiki/MMP24" title="MMP24">MMP24</a></li> <li><a href="/wiki/MMP25" title="MMP25">MMP25</a></li> <li><a href="/wiki/MMP26" title="MMP26">MMP26</a></li> <li><a href="/wiki/MMP27" title="MMP27">MMP27</a></li> <li><a href="/wiki/MMP28" title="MMP28">MMP28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neprilysin" title="Neprilysin">Neprilysin</a></li> <li><a href="/wiki/Procollagen_peptidase" title="Procollagen peptidase">Procollagen peptidase</a></li> <li><a href="/wiki/Thermolysin" title="Thermolysin">Thermolysin</a></li> <li><a href="/wiki/Pregnancy-associated_plasma_protein_A" class="mw-redirect" title="Pregnancy-associated plasma protein A">Pregnancy-associated plasma protein A</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_1" title="Bone morphogenetic protein 1">Bone morphogenetic protein 1</a></li> <li><a href="/wiki/Lysostaphin" title="Lysostaphin">Lysostaphin</a></li> <li><a href="/wiki/Insulin-degrading_enzyme" title="Insulin-degrading enzyme">Insulin-degrading enzyme</a></li> <li><a href="/wiki/ZMPSTE24" title="ZMPSTE24">ZMPSTE24</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output 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