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href="/search/?q=author%3AXie%2C%20Ke">Xie, Ke</a>; </li><li><a href="/search/?q=author%3AMiao%2C%20Rui">Miao, Rui</a>; </li><li><a href="/search/?q=author%3AOzden%2C%20Adnan">Ozden, Adnan</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Shijie">Liu, Shijie</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Zhu">Chen, Zhu</a>; </li><li><a href="/search/?q=author%3ADinh%2C%20Cao-Thang">Dinh, Cao-Thang</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Jianan">Huang, Jianan</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Qiucheng">Xu, Qiucheng</a>; </li><li><a href="/search/?q=author%3AGabardo%2C%20Christine">Gabardo, Christine</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Geonhui">Lee, Geonhui</a>; </li><li><a href="/search/?q=author%3AEdwards%2C%20Jonathan">Edwards, Jonathan</a>; </li><li><a href="/search/?q=author%3AOBrien%2C%20Colin">OBrien, Colin</a>; </li><li><a href="/search/?q=author%3ABoettcher%2C%20Shannon">Boettcher, Shannon</a>; </li><li><a href="/search/?q=author%3ASinton%2C%20David">Sinton, David</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ASargent%2C%20Edward">Sargent, Edward</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucb_postprints">UC Berkeley Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">In alkaline and neutral MEA CO2 electrolyzers, CO2 rapidly converts to (bi)carbonate, imposing a significant energy penalty arising from separating CO2 from the anode gas outlets. Here we report a CO2 electrolyzer uses a bipolar membrane (BPM) to convert (bi)carbonate back to CO2, preventing crossover; and that surpasses the single-pass utilization (SPU) limit (25% for multi-carbon products, C2+) suffered by previous neutral-media electrolyzers. We employ a stationary unbuffered catholyte layer between BPM and cathode to promote C2+ products while ensuring that (bi)carbonate is converted back, in situ, to CO2 near the cathode. We develop a model that enables the design of the catholyte layer, finding that limiting the diffusion path length of reverted CO2 to ~10鈥壩糾 balances the CO2 diffusion flux with the regeneration rate. We report a single-pass CO2 utilization of 78%, which lowers the energy associated with downstream separation of CO2 by 10脳 compared with past systems.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/260210xz"><img src="/cms-assets/184adee6a7a3566a9a97674de06321dfc0eb375895180529adedd4bfa793be95" alt="Cover page: Bipolar membrane electrolyzers enable high single-pass CO2 electroreduction to multicarbon products."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9kt9c853"><div class="c-clientmarkup">E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ALee%2C%20Geonhui">Lee, Geonhui</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Claudia">Wong, Claudia</a>; </li><li><a href="/search/?q=author%3ACho%2C%20Anna">Cho, Anna</a>; </li><li><a href="/search/?q=author%3AWest%2C%20Junior">West, Junior</a>; </li><li><a href="/search/?q=author%3ACrawford%2C%20Ashleigh">Crawford, Ashleigh</a>; </li><li><a href="/search/?q=author%3ARusso%2C%20Gabriella">Russo, Gabriella</a>; </li><li><a href="/search/?q=author%3ASi%2C%20Bishwa">Si, Bishwa</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Jungwoo">Kim, Jungwoo</a>; </li><li><a href="/search/?q=author%3AHoffner%2C%20Lauren">Hoffner, Lauren</a>; </li><li><a href="/search/?q=author%3AJang%2C%20Cholsoon">Jang, Cholsoon</a>; </li><li><a href="/search/?q=author%3AJung%2C%20Moonjung">Jung, Moonjung</a>; </li><li><a href="/search/?q=author%3ALeone%2C%20Robert">Leone, Robert</a>; </li><li><a href="/search/?q=author%3AKonstantopoulos%2C%20Konstantinos">Konstantopoulos, Konstantinos</a>; </li><li><a href="/search/?q=author%3AEwald%2C%20Andrew">Ewald, Andrew</a>; </li><li><a href="/search/?q=author%3AWirtz%2C%20Denis">Wirtz, Denis</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AJeong%2C%20Sangmoo">Jeong, Sangmoo</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in metastasis by mediating the epithelial-mesenchymal transition, which promotes invasion and migration of cancer cells. However, recent studies have demonstrated that E-cadherin supports the survival and proliferation of metastatic cancer cells. Here, we identified a metabolic role for E-cadherin in breast cancer by upregulating the de novo serine synthesis pathway (SSP). The upregulated SSP provided metabolic precursors for biosynthesis and resistance to oxidative stress, enabling E-cadherin+ breast cancer cells to achieve faster tumor growth and enhanced metastases. Inhibition of phosphoglycerate dehydrogenase, a rate-limiting enzyme in the SSP, significantly and specifically hampered proliferation of E-cadherin+ breast cancer cells and rendered them vulnerable to oxidative stress, inhibiting their metastatic potential. These findings reveal that E-cadherin reprograms cellular metabolism, promoting tumor growth and metastasis of breast cancers. Significance: E-Cadherin promotes the progression and metastasis of breast cancer by upregulating the de novo serine synthesis pathway, offering promising targets for inhibiting tumor growth and metastasis in E-cadherin-expressing tumors.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9kt9c853"><img src="/cms-assets/19b603d8f4dbcd7c63dca9384933c12e724b312feb82f98e4f274829cd127a22" alt="Cover page: E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer."/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright 漏 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>