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class="c-checkbox"></ul></fieldset></details></div></div><button type="submit" id="facet-form-submit" style="display:none">Search</button></div></aside><main id="maincontent"><section class="o-columnbox1"><header><h2 class="o-columnbox1__heading" aria-live="polite">Scholarly Works (3 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/0cc4w568"><div class="c-clientmarkup">Adhesion-independent topography-based leukocyte migration.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AFriedl%2C%20Peter">Friedl, Peter</a>; </li><li><a href="/search/?q=author%3AKonstantopoulos%2C%20Konstantinos">Konstantopoulos, Konstantinos</a>; </li><li><a href="/search/?q=author%3ASahai%2C%20Erik">Sahai, Erik</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AWeiner%2C%20Orion">Weiner, Orion</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Cells need to couple intracellular actin flows with the substrate to generate forward movement. This has traditionally been studied in the context of specific transmembrane receptors, particularly integrin adhesion receptors, which link extracellular adhesive molecules to the actin cytoskeleton. However, leukocytes and other cells can also migrate using integrin-independent strategies both <i>in vivo</i> and <i>in vitro</i>, though the cellular and environmental requirements for this mode are not fully understood. In seminal recent work, Reversat <i>et al</i>.<sup>1</sup> develop a range of innovative 2D and 3D engineered microdevices and probe the biophysical mechanisms underlying T lymphocytes and dendritic cells in conditions of limited substrate adhesion. They identify a physical principle of mechano-coupling between retrograde actin flow and irregular extracellular confinement, which allows the cell to generate mechanical resistance and move in the absence of receptor-mediated adhesion. Through the combined use of experiments and theoretical modeling, this work resolves a long-standing question in cell biology and establishes mechanical interaction with an irregular-shaped 3D environment which may be relevant to cell migration in a range of tissue contexts.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/0cc4w568"><img src="/cms-assets/73904e2f1423ddb3db66e05a22b77d8a5f8b3bba1cb89ff9f046c752e22618e1" alt="Cover page: Adhesion-independent topography-based leukocyte migration."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9kt9c853"><div class="c-clientmarkup">E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ALee%2C%20Geonhui">Lee, Geonhui</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Claudia">Wong, Claudia</a>; </li><li><a href="/search/?q=author%3ACho%2C%20Anna">Cho, Anna</a>; </li><li><a href="/search/?q=author%3AWest%2C%20Junior">West, Junior</a>; </li><li><a href="/search/?q=author%3ACrawford%2C%20Ashleigh">Crawford, Ashleigh</a>; </li><li><a href="/search/?q=author%3ARusso%2C%20Gabriella">Russo, Gabriella</a>; </li><li><a href="/search/?q=author%3ASi%2C%20Bishwa">Si, Bishwa</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Jungwoo">Kim, Jungwoo</a>; </li><li><a href="/search/?q=author%3AHoffner%2C%20Lauren">Hoffner, Lauren</a>; </li><li><a href="/search/?q=author%3AJang%2C%20Cholsoon">Jang, Cholsoon</a>; </li><li><a href="/search/?q=author%3AJung%2C%20Moonjung">Jung, Moonjung</a>; </li><li><a href="/search/?q=author%3ALeone%2C%20Robert">Leone, Robert</a>; </li><li><a href="/search/?q=author%3AKonstantopoulos%2C%20Konstantinos">Konstantopoulos, Konstantinos</a>; </li><li><a href="/search/?q=author%3AEwald%2C%20Andrew">Ewald, Andrew</a>; </li><li><a href="/search/?q=author%3AWirtz%2C%20Denis">Wirtz, Denis</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AJeong%2C%20Sangmoo">Jeong, Sangmoo</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">The loss of E-cadherin, an epithelial cell adhesion molecule, has been implicated in metastasis by mediating the epithelial-mesenchymal transition, which promotes invasion and migration of cancer cells. However, recent studies have demonstrated that E-cadherin supports the survival and proliferation of metastatic cancer cells. Here, we identified a metabolic role for E-cadherin in breast cancer by upregulating the de novo serine synthesis pathway (SSP). The upregulated SSP provided metabolic precursors for biosynthesis and resistance to oxidative stress, enabling E-cadherin+ breast cancer cells to achieve faster tumor growth and enhanced metastases. Inhibition of phosphoglycerate dehydrogenase, a rate-limiting enzyme in the SSP, significantly and specifically hampered proliferation of E-cadherin+ breast cancer cells and rendered them vulnerable to oxidative stress, inhibiting their metastatic potential. These findings reveal that E-cadherin reprograms cellular metabolism, promoting tumor growth and metastasis of breast cancers. Significance: E-Cadherin promotes the progression and metastasis of breast cancer by upregulating the de novo serine synthesis pathway, offering promising targets for inhibiting tumor growth and metastasis in E-cadherin-expressing tumors.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9kt9c853"><img src="/cms-assets/19b603d8f4dbcd7c63dca9384933c12e724b312feb82f98e4f274829cd127a22" alt="Cover page: E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/3cx649mf"><div class="c-clientmarkup">A physical sciences network characterization of non-tumorigenic and metastatic cells</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AAgus%2C%20David%20B">Agus, David B</a>; </li><li><a href="/search/?q=author%3AAlexander%2C%20Jenolyn%20F">Alexander, Jenolyn F</a>; </li><li><a href="/search/?q=author%3AArap%2C%20Wadih">Arap, Wadih</a>; </li><li><a href="/search/?q=author%3AAshili%2C%20Shashanka">Ashili, Shashanka</a>; </li><li><a href="/search/?q=author%3AAslan%2C%20Joseph%20E">Aslan, Joseph E</a>; </li><li><a href="/search/?q=author%3AAustin%2C%20Robert%20H">Austin, Robert H</a>; </li><li><a href="/search/?q=author%3ABackman%2C%20Vadim">Backman, Vadim</a>; </li><li><a href="/search/?q=author%3ABethel%2C%20Kelly%20J">Bethel, Kelly J</a>; </li><li><a href="/search/?q=author%3ABonneau%2C%20Richard">Bonneau, Richard</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Wei-Chiang">Chen, Wei-Chiang</a>; </li><li><a href="/search/?q=author%3AChen-Tanyolac%2C%20Chira">Chen-Tanyolac, Chira</a>; </li><li><a href="/search/?q=author%3AChoi%2C%20Nathan%20C">Choi, Nathan C</a>; </li><li><a href="/search/?q=author%3ACurley%2C%20Steven%20A">Curley, Steven A</a>; </li><li><a href="/search/?q=author%3ADallas%2C%20Matthew">Dallas, Matthew</a>; </li><li><a href="/search/?q=author%3ADamania%2C%20Dhwanil">Damania, Dhwanil</a>; </li><li><a href="/search/?q=author%3ADavies%2C%20Paul%20CW">Davies, Paul CW</a>; </li><li><a href="/search/?q=author%3ADecuzzi%2C%20Paolo">Decuzzi, Paolo</a>; </li><li><a href="/search/?q=author%3ADickinson%2C%20Laura">Dickinson, Laura</a>; </li><li><a href="/search/?q=author%3AEstevez-Salmeron%2C%20Luis">Estevez-Salmeron, Luis</a>; </li><li><a href="/search/?q=author%3AEstrella%2C%20Veronica">Estrella, Veronica</a>; </li><li><a href="/search/?q=author%3AFerrari%2C%20Mauro">Ferrari, Mauro</a>; </li><li><a href="/search/?q=author%3AFischbach%2C%20Claudia">Fischbach, Claudia</a>; </li><li><a href="/search/?q=author%3AFoo%2C%20Jasmine">Foo, Jasmine</a>; </li><li><a href="/search/?q=author%3AFraley%2C%20Stephanie%20I">Fraley, Stephanie I</a>; </li><li><a href="/search/?q=author%3AFrantz%2C%20Christian">Frantz, Christian</a>; </li><li><a href="/search/?q=author%3AFuhrmann%2C%20Alexander">Fuhrmann, Alexander</a>; </li><li><a href="/search/?q=author%3AGascard%2C%20Philippe">Gascard, Philippe</a>; </li><li><a href="/search/?q=author%3AGatenby%2C%20Robert%20A">Gatenby, Robert A</a>; </li><li><a href="/search/?q=author%3AGeng%2C%20Yue">Geng, Yue</a>; </li><li><a href="/search/?q=author%3AGerecht%2C%20Sharon">Gerecht, Sharon</a>; </li><li><a href="/search/?q=author%3AGillies%2C%20Robert%20J">Gillies, Robert J</a>; </li><li><a href="/search/?q=author%3AGodin%2C%20Biana">Godin, Biana</a>; </li><li><a href="/search/?q=author%3AGrady%2C%20William%20M">Grady, William M</a>; </li><li><a href="/search/?q=author%3AGreenfield%2C%20Alex">Greenfield, Alex</a>; </li><li><a href="/search/?q=author%3AHemphill%2C%20Courtney">Hemphill, Courtney</a>; </li><li><a href="/search/?q=author%3AHempstead%2C%20Barbara%20L">Hempstead, Barbara L</a>; </li><li><a href="/search/?q=author%3AHielscher%2C%20Abigail">Hielscher, Abigail</a>; </li><li><a href="/search/?q=author%3AHillis%2C%20W%20Daniel">Hillis, W Daniel</a>; </li><li><a href="/search/?q=author%3AHolland%2C%20Eric%20C">Holland, Eric C</a>; </li><li><a href="/search/?q=author%3AIbrahim-Hashim%2C%20Arig">Ibrahim-Hashim, Arig</a>; </li><li><a href="/search/?q=author%3AJacks%2C%20Tyler">Jacks, Tyler</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Roger%20H">Johnson, Roger H</a>; </li><li><a href="/search/?q=author%3AJoo%2C%20Ahyoung">Joo, Ahyoung</a>; </li><li><a href="/search/?q=author%3AKatz%2C%20Jonathan%20E">Katz, Jonathan E</a>; </li><li><a href="/search/?q=author%3AKelbauskas%2C%20Laimonas">Kelbauskas, Laimonas</a>; </li><li><a href="/search/?q=author%3AKesselman%2C%20Carl">Kesselman, Carl</a>; </li><li><a href="/search/?q=author%3AKing%2C%20Michael%20R">King, Michael R</a>; </li><li><a href="/search/?q=author%3AKonstantopoulos%2C%20Konstantinos">Konstantopoulos, Konstantinos</a>; </li><li><a href="/search/?q=author%3AKraning-Rush%2C%20Casey%20M">Kraning-Rush, Casey M</a>; </li><li><a href="/search/?q=author%3AKuhn%2C%20Peter">Kuhn, Peter</a>; </li><li><a href="/search/?q=author%3AKung%2C%20Kevin">Kung, Kevin</a>; </li><li><a href="/search/?q=author%3AKwee%2C%20Brian">Kwee, Brian</a>; </li><li><a href="/search/?q=author%3ALakins%2C%20Johnathon%20N">Lakins, Johnathon N</a>; </li><li><a href="/search/?q=author%3ALambert%2C%20Guillaume">Lambert, Guillaume</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20David">Liao, David</a>; </li><li><a href="/search/?q=author%3ALicht%2C%20Jonathan%20D">Licht, Jonathan D</a>; </li><li><a href="/search/?q=author%3ALiphardt%2C%20Jan%20T">Liphardt, Jan T</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Liyu">Liu, Liyu</a>; </li><li><a href="/search/?q=author%3ALloyd%2C%20Mark%20C">Lloyd, Mark C</a>; </li><li><a href="/search/?q=author%3ALyubimova%2C%20Anna">Lyubimova, Anna</a>; </li><li><a href="/search/?q=author%3AMallick%2C%20Parag">Mallick, Parag</a>; </li><li><a href="/search/?q=author%3AMarko%2C%20John">Marko, John</a>; </li><li><a href="/search/?q=author%3AMcCarty%2C%20Owen%20JT">McCarty, Owen JT</a>; </li><li><a href="/search/?q=author%3AMeldrum%2C%20Deirdre%20R">Meldrum, Deirdre R</a>; </li><li><a href="/search/?q=author%3AMichor%2C%20Franziska">Michor, Franziska</a>; </li><li><a href="/search/?q=author%3AMumenthaler%2C%20Shannon%20M">Mumenthaler, Shannon M</a>; </li><li><a href="/search/?q=author%3ANandakumar%2C%20Vivek">Nandakumar, Vivek</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Halloran%2C%20Thomas%20V">O鈥橦alloran, Thomas V</a>; </li><li><a href="/search/?q=author%3AOh%2C%20Steve">Oh, Steve</a>; </li><li><a href="/search/?q=author%3APasqualini%2C%20Renata">Pasqualini, Renata</a>; </li><li><a href="/search/?q=author%3APaszek%2C%20Matthew%20J">Paszek, Matthew J</a>; </li><li><a href="/search/?q=author%3APhilips%2C%20Kevin%20G">Philips, Kevin G</a>; </li><li><a href="/search/?q=author%3APoultney%2C%20Christopher%20S">Poultney, Christopher S</a>; </li><li><a href="/search/?q=author%3ARana%2C%20Kuldeepsinh">Rana, Kuldeepsinh</a>; </li><li><a href="/search/?q=author%3AReinhart-King%2C%20Cynthia%20A">Reinhart-King, Cynthia A</a>; </li><li><a href="/search/?q=author%3ARos%2C%20Robert">Ros, Robert</a>; </li><li><a href="/search/?q=author%3ASemenza%2C%20Gregg%20L">Semenza, Gregg L</a>; </li><li><a href="/search/?q=author%3ASenechal%2C%20Patti">Senechal, Patti</a>; </li><li><a href="/search/?q=author%3AShuler%2C%20Michael%20L">Shuler, Michael L</a>; </li><li><a href="/search/?q=author%3ASrinivasan%2C%20Srimeenakshi">Srinivasan, Srimeenakshi</a>; </li><li><a href="/search/?q=author%3AStaunton%2C%20Jack%20R">Staunton, Jack R</a>; </li><li><a href="/search/?q=author%3AStypula%2C%20Yolanda">Stypula, Yolanda</a>; </li><li><a href="/search/?q=author%3ASubramanian%2C%20Hariharan">Subramanian, Hariharan</a>; </li><li><a href="/search/?q=author%3ATlsty%2C%20Thea%20D">Tlsty, Thea D</a>; </li><li><a href="/search/?q=author%3ATormoen%2C%20Garth%20W">Tormoen, Garth W</a>; </li><li><a href="/search/?q=author%3ATseng%2C%20Yiider">Tseng, Yiider</a>; </li><li><a href="/search/?q=author%3Avan%20Oudenaarden%2C%20Alexander">van Oudenaarden, Alexander</a>; </li><li><a href="/search/?q=author%3AVerbridge%2C%20Scott%20S">Verbridge, Scott S</a>; </li><li><a href="/search/?q=author%3AWan%2C%20Jenny%20C">Wan, Jenny C</a>; </li><li><a href="/search/?q=author%3AWeaver%2C%20Valerie%20M">Weaver, Valerie M</a>; </li><li><a href="/search/?q=author%3AWidom%2C%20Jonathan">Widom, Jonathan</a>; </li><li><a href="/search/?q=author%3AWill%2C%20Christine">Will, Christine</a>; </li><li><a href="/search/?q=author%3AWirtz%2C%20Denis">Wirtz, Denis</a>; </li><li><a href="/search/?q=author%3AWojtkowiak%2C%20Jonathan">Wojtkowiak, Jonathan</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AWu%2C%20Pei-Hsun">Wu, Pei-Hsun</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsd_postprints">UC San Diego Previously Published Works</a> (2013)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles. Model-based multi-omics approaches identified key differences between these cells' regulatory networks involved in morphology and survival. These results provide a multifaceted description of cellular parameters of two widely used cell lines and demonstrate the value of the PS-OC Network approach for integration of diverse experimental observations to elucidate the phenotypes associated with cancer metastasis.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/3cx649mf"><img src="/cms-assets/bd8d1afe95b207509acd71df53aa734cfcba4ff20ba79fa9bef458ce68caf914" alt="Cover page: A physical sciences network characterization of non-tumorigenic and metastatic cells"/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright 漏 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>