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Rhea - reaction knowledgebase
<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en"> <head> <title>Rhea - reaction knowledgebase</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="google" content="notranslate" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <meta name="description" content="An expert-curated knowledgebase of chemical and transport reactions of biological interest" /> <link rel="preload" href="/style/fonts/material-design.woff2" as="font" type="font/woff2" crossorigin="anonymous" /> <link rel="stylesheet" media="screen" href="/style/css/index.3b7a309297245614b787.css" /> <script type="text/javascript"> if (!('customElements' in window)) { let el = document.createElement('script'); el.setAttribute('src', '/js/customelements.js'); document.querySelector('head').appendChild(el); } </script> <!-- Matomo --> <script> var _paq = window._paq = window._paq || []; /* tracker methods like "setCustomDimension" should be called 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"Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest - and the standard for enzyme and transporter annotation in UniProtKB.", "license": { "@type": "CreativeWork", "name": "Attribution 4.0 International (CC BY 4.0)", "url": "https://creativecommons.org/licenses/by/4.0/" }, "citation": { "@type": "ScholarlyArticle", "@id": "https://doi.org/10.1093/nar/gkab1016", "name": "Rhea, the reaction knowledgebase in 2022.", "author": [ {"@type": "Person", "givenName": "Parit", "familyName": "Bansal", "@id": "https://orcid.org/0000-0002-0875-1680"}, {"@type": "Person", "givenName": "Anne", "familyName": "Morgat", "@id": "https://orcid.org/0000-0002-1216-2969"}, {"@type": "Person", "givenName": "Kristian B", "familyName": "Axelsen", "@id": "https://orcid.org/0000-0003-3889-2879"}, {"@type": "Person", "givenName": "Venkatesh", "familyName": "Muthukrishnan", "@id": "https://orcid.org/0000-0002-6850-9888"}, {"@type": "Person", "givenName": "Elisabeth", "familyName": "Coudert", "@id": "https://orcid.org/0000-0001-8314-404X"}, {"@type": "Person", "givenName": "Lucila", "familyName": "Aimo", "@id": "https://orcid.org/0000-0003-0943-6401"}, {"@type": "Person", "givenName": "Nevila", "familyName": "Hyka-Nouspikel", "@id": "https://orcid.org/0000-0001-7855-209X"}, {"@type": "Person", "givenName": "Elisabeth", "familyName": "Gasteiger", "@id": "https://orcid.org/0000-0003-1829-162X"}, {"@type": "Person", "givenName": "Arnaud", "familyName": "Kerhornou", "@id": "https://orcid.org/0000-0002-2890-295X"}, {"@type": "Person", "givenName": "Teresa", "familyName": "Batista Neto", "@id": "https://orcid.org/0000-0003-4543-637X"}, {"@type": "Person", "givenName": "Monica", "familyName": "Pozzato", "@id": "https://orcid.org/0000-0002-3080-5243"}, {"@type": "Person", "givenName": "Marie-Claude", "familyName": "Blatter", "@id": "https://orcid.org/0000-0002-7474-1499"}, {"@type": "Person", "givenName": "Alex", "familyName": "Ignatchenko"}, {"@type": "Person", "givenName": "Nicole", "familyName": "Redaschi", "@id": "https://orcid.org/0000-0001-8890-2268"}, {"@type": "Person", "givenName": "Alan", "familyName": "Bridge", "@id": "https://orcid.org/0000-0003-2148-9135"} ], "sameAs": "https://pubmed.ncbi.nlm.nih.gov/pubmed/34755880" }, "provider": { "@type": "Organization", "name": "SIB Swiss Institute of Bioinformatics", "@id": "https://ror.org/002n09z45", "url": "https://sib.swiss" } }, "potentialAction" : { "@type":"SearchAction", "target": { "@type" : "EntryPoint" , "urlTemplate": "https://rhea-db.org/rhea?query={query}" }, "query-input" : { "@type" : "PropertyValueSpecification" , "valueName" : "query", "defaultValue" : "*" } } } </script> </head> <body> <header class="row-container"> <div class="logos"> <a class="sib_logo" href="https://www.sib.swiss"> <img alt="SIB logo" style="height: 50px" src="/style/images/sib_logo_short.png" /> </a> <a class="rhea_logo" href="/"> <img alt="Rhea logo" style="height: 50px" src="/style/images/rhea_logo.png" /> </a> </div> <nav role="navigation" itemscope itemtype="http://www.schema.org/SiteNavigationElement" class="row-container"> <a itemprop="url" href="/structuresearch"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24"><path d="M0 0h24v24H0z" fill="none"/><path d="M4.59 6.89c.7-.71 1.4-1.35 1.71-1.22.5.2 0 1.03-.3 1.52-.25.42-2.86 3.89-2.86 6.31 0 1.28.48 2.34 1.34 2.98.75.56 1.74.73 2.64.46 1.07-.31 1.95-1.4 3.06-2.77 1.21-1.49 2.83-3.44 4.08-3.44 1.63 0 1.65 1.01 1.76 1.79-3.78.64-5.38 3.67-5.38 5.37 0 1.7 1.44 3.09 3.21 3.09 1.63 0 4.29-1.33 4.69-6.1H21v-2.5h-2.47c-.15-1.65-1.09-4.2-4.03-4.2-2.25 0-4.18 1.91-4.94 2.84-.58.73-2.06 2.48-2.29 2.72-.25.3-.68.84-1.11.84-.45 0-.72-.83-.36-1.92.35-1.09 1.4-2.86 1.85-3.52.78-1.14 1.3-1.92 1.3-3.28C8.95 3.69 7.31 3 6.44 3 5.12 3 3.97 4 3.72 4.25c-.36.36-.66.66-.88.93l1.75 1.71zm9.29 11.66c-.31 0-.74-.26-.74-.72 0-.6.73-2.2 2.87-2.76-.3 2.69-1.43 3.48-2.13 3.48z"/></svg> <span itemprop="name">Structure search</span> </a> <a itemprop="url" href="/mapping"> <svg xmlns="http://www.w3.org/2000/svg" enable-background="new 0 0 24 24" height="24" viewBox="0 0 24 24" width="24"><g><rect fill="none" height="24" width="24" x="0"/></g><g><g><g><path d="M9.01,14H2v2h7.01v3L13,15l-3.99-4V14z M14.99,13v-3H22V8h-7.01V5L11,9L14.99,13z"/></g></g></g></svg> <span itemprop="name">Retrieve/ID mapping</span> </a> <a itemprop="url" class="sparqlEndpoint" href="https://sparql.rhea-db.org/sparql"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24"><path d="M0 0h24v24H0z" fill="none"/><path d="M3.9 12c0-1.71 1.39-3.1 3.1-3.1h4V7H7c-2.76 0-5 2.24-5 5s2.24 5 5 5h4v-1.9H7c-1.71 0-3.1-1.39-3.1-3.1zM8 13h8v-2H8v2zm9-6h-4v1.9h4c1.71 0 3.1 1.39 3.1 3.1s-1.39 3.1-3.1 3.1h-4V17h4c2.76 0 5-2.24 5-5s-2.24-5-5-5z"/></svg> <span itemprop="name">SPARQL</span> </a> <a itemprop="url" href="/help/download"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24"><path d="M0 0h24v24H0z" fill="none"/><path d="M19.35 10.04C18.67 6.59 15.64 4 12 4 9.11 4 6.6 5.64 5.35 8.04 2.34 8.36 0 10.91 0 14c0 3.31 2.69 6 6 6h13c2.76 0 5-2.24 5-5 0-2.64-2.05-4.78-4.65-4.96zM17 13l-5 5-5-5h3V9h4v4h3z"/></svg> <span itemprop="name">Download</span> </a> <a itemprop="url" href="/help"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24"><path d="M0 0h24v24H0V0z" fill="none"/><path d="M19.07 4.93l-1.41 1.41C19.1 7.79 20 9.79 20 12c0 4.42-3.58 8-8 8s-8-3.58-8-8c0-4.08 3.05-7.44 7-7.93v2.02C8.16 6.57 6 9.03 6 12c0 3.31 2.69 6 6 6s6-2.69 6-6c0-1.66-.67-3.16-1.76-4.24l-1.41 1.41C15.55 9.9 16 10.9 16 12c0 2.21-1.79 4-4 4s-4-1.79-4-4c0-1.86 1.28-3.41 3-3.86v2.14c-.6.35-1 .98-1 1.72 0 1.1.9 2 2 2s2-.9 2-2c0-.74-.4-1.38-1-1.72V2h-1C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10c0-2.76-1.12-5.26-2.93-7.07z"/></svg> <span itemprop="name">Help</span> </a> <a itemprop="url" href="/feedback"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24"><path d="M0 0h24v24H0z" fill="none"/><path d="M20 4H4c-1.1 0-1.99.9-1.99 2L2 18c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V6c0-1.1-.9-2-2-2zm0 4l-8 5-8-5V6l8 5 8-5v2z"/></svg> <span itemprop="name">Feedback</span> </a> </nav> </header> <main class="column-container"> <section class="formContainer"> <!-- remove comment to add back the banner <p th:replace="webroot/fragments.html :: banner"></p> --> <div class="row-container stats"> <span>Current release <span>137</span> <span>(2025-02-05):</span> <span>17,422</span> reactions with <span>14,335</span> unique compounds from <span>18,284</span> unique references (see <a class="highlight" href="/statistics">statistics</a> and <a class="highlight" href="https://ftp.expasy.org/databases/rhea/rhea_news.html">news</a>) </span> </div> <div class="column-container hero"> <h2>Find Rhea reactions</h2> <div class="row-container formwrapper"> <form id="searchForm" action="/rhea" method="get"> <input name="query" value="" type="text" size="100" autocomplete="off" id="query" autofocus="autofocus" placeholder="ex:adenosine / CHEBI:29748 / RHEA:16505 / 4.1.3.40 / inchikey:XLYOFNOQVPJJNP-UHFFFAOYSA-N ..."></input> </form> <button form="searchForm" type="submit" id="search-button">Search</button> </div> <div class="row-container" style="justify-content: flex-start; align-items: baseline;"> <rhea-search-examples></rhea-search-examples> <a id="advanced-search-button">Advanced search</a> <a id="browse-button">Browse</a> </div> <div class="advanced-search" style="display: none"></div> <div class="herofooter"> Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest - and the standard for enzyme and transporter annotation in UniProtKB. Rhea uses the chemical dictionary <a href="https://www.ebi.ac.uk/chebi/">ChEBI</a> (Chemical Entities of Biological Interest) to describe reaction participants. <a class="learnmore" href="/help">Learn more...</a> <span class="citation"> Cite us: <span>Rhea, the reaction knowledgebase in 2022</span> (PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/34755880/">34755880</a>, DOI:<a href="https://doi.org/10.1093/nar/gkab1016">10.1093/nar/gkab1016</a>) </span> </div> </div> </section> <section class="tutorials-container row-container"> <div class="tutorials-wrapper"> <h2 class="section-title">Get started</h2> <div class="row-container youtube-container"> <a target="_blank" href="https://youtu.be/XDcN8L5KqS8"> <div class="icon"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></div> <img src="https://i.ytimg.com/vi/XDcN8L5KqS8/sddefault.jpg"></img> </a> <a target="_blank" href="https://youtu.be/yWi3e7xbp_A"> <div class="icon"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></div> <img src="https://i.ytimg.com/vi/yWi3e7xbp_A/sddefault.jpg"></img> </a> </div> <h4 class="section-title">Tutorials: How to search Rhea by</h4> <!-- https://www.flaticon.com/free-icons/molecule --> <div class="tutorials"> <div class="tutorial column-container"> <div class="tutorial-icon"> <img alt="chebi" width="64px" height="64px" src="/style/images/chebi.png" /> <!--<svg id="Layer_1" height="50" viewBox="0 0 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d="m426.351 266.162a8.015 8.015 0 0 0 -7.465-2.962l-117.72 17.521a8.022 8.022 0 0 0 -6.267 4.987l-43.799 111.448a8.03 8.03 0 0 0 1.16 7.875l73.94 93.916a8.015 8.015 0 0 0 7.463 2.964l117.723-17.522a8.023 8.023 0 0 0 6.267-4.987l43.8-111.448a8.03 8.03 0 0 0 -1.16-7.875zm20.98 206.7-113.139 16.838-71.087-90.29 42.116-107.16 113.139-16.84 71.087 90.29z" fill="url(#linear-gradient-3)"/><path d="m288.349 245.838a8 8 0 0 0 7.462 2.963l117.723-17.522a8.024 8.024 0 0 0 6.267-4.987l43.8-111.447a8.025 8.025 0 0 0 -1.16-7.876l-73.941-93.915a8.017 8.017 0 0 0 -7.463-2.965l-117.723 17.522a8.021 8.021 0 0 0 -6.267 4.987l-43.8 111.447a8.027 8.027 0 0 0 1.159 7.876zm94.451-223.88h-.013zm-115.431 17.182 113.138-16.84 71.093 90.29-42.121 107.16-113.139 16.84-71.087-90.29z" fill="url(#linear-gradient-4)"/><path d="m65.3 316.756a6 6 0 1 0 -9.423 7.431l34.239 43.413a6 6 0 1 0 9.422-7.431z" fill="url(#linear-gradient-5)"/><path d="m54.45 301.605-3.127-4.582a6 6 0 0 0 -9.911 6.765l3.127 4.582a6 6 0 0 0 9.911-6.765z" fill="url(#linear-gradient-6)"/><path d="m302.161 211.731a6 6 0 0 0 1-8.426l-34.239-43.416a6 6 0 0 0 -9.423 7.43l34.24 43.416a6 6 0 0 0 8.427 1z" fill="url(#linear-gradient-7)"/><path d="m258.069 144.738-3.127-4.582a6 6 0 0 0 -9.912 6.763l3.126 4.582a6 6 0 0 0 9.913-6.763z" fill="url(#linear-gradient-8)"/><path d="m442.976 435.141a6 6 0 0 0 7.817-3.3l22.907-56.341a6 6 0 0 0 -11.116-4.519l-22.9 56.341a6 6 0 0 0 3.292 7.819z" fill="url(#linear-gradient-9)"/></svg>--> </div> <p> <span class="tutorial-link"><span>Chemical classes (ChEBI)</span></span> <a href="https://youtu.be/0tow_vBNir8"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></a> </p> </div> <div class="tutorial column-container"> <div class="tutorial-icon"> <!-- https://www.flaticon.com/free-icon/molecule_2106370 --> <svg id="Capa_1" enable-background="new 0 0 512 512" viewBox="0 0 512 512" xmlns="http://www.w3.org/2000/svg"> <g fill="#daeaef"> <path d="m256 178.589c-4.267 0-7.726-3.459-7.726-7.726v-65.563c0-4.267 3.459-7.726 7.726-7.726s7.726 3.459 7.726 7.726v65.563c0 4.267-3.459 7.726-7.726 7.726z" /> <path d="m389.114 263.726h-45.696c-4.267 0-7.726-3.459-7.726-7.726s3.459-7.726 7.726-7.726h45.696c4.267 0 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0-34.047-4.854-48.109-13.289 16.369 27.286 46.234 45.55 80.369 45.55 51.726 0 93.659-41.932 93.659-93.659.001-34.136-18.263-64.002-45.549-80.37z" fill="#fb636f" /> <path d="m322.602 300.526 62.439 62.439-22.075 22.075-62.439-62.439c-6.096-6.096-6.096-15.979 0-22.075 6.095-6.095 15.979-6.095 22.075 0z" fill="#daeaef" /> <circle cx="421.463" cy="421.463" fill="#97e4f9" r="72.846" /> <path d="m456.053 357.342c5.563 10.291 8.724 22.07 8.724 34.59 0 40.232-32.614 72.846-72.846 72.846-12.519 0-24.299-3.161-34.59-8.724 12.314 22.78 36.409 38.256 64.122 38.256 40.231 0 72.846-32.614 72.846-72.846 0-27.713-15.476-51.808-38.256-64.122z" fill="#0acefa" /> <circle cx="256" cy="79.089" fill="#97e4f9" r="31.22" /> <circle cx="412.098" cy="256" fill="#97e4f9" r="31.22" /> <circle cx="31.22" cy="256" fill="#97e4f9" r="31.22" /> <circle cx="256" cy="432.911" fill="#97e4f9" r="31.22" /></svg> </div> <p> <span class="tutorial-link"><span>Chemical structures (InChIKey)</span></span> <a href="https://youtu.be/wVSyMmhYUMA"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></a> </p> </div> <div class="tutorial column-container"> <div class="tutorial-icon"> <!-- https://www.flaticon.com/free-icon/chemistry_2286308 --> <img alt="chemistry" src="/style/images/25.svg" /> <!--<svg id="Capa_2" enable-background="new 0 0 512 512" viewBox="0 0 512 512" xmlns="http://www.w3.org/2000/svg"><g><g><path d="m311.635 130.421h55.578v15.458h-55.578z" fill="#cbcbcb" transform="matrix(.617 -.787 .787 .617 21.259 319.989)"/></g><path d="m493.431 237.083-2.269-15.292-43.242 6.417v-44.299h-15.459v46.594l-55.787 8.279-49.936-86.493h-100.365l-27.023-53.73.159-.013-.189-2.242 38.344-42.585-11.488-10.344-28.633 31.799-4.173-49.615-15.405 1.296 4.729 56.225-81.288-36.192-6.288 14.122 87.676 39.036 30.035 59.719-46.522 80.579-100.61 21.385-10.688 101.692-41.997 23.549 7.561 13.485 42.105-23.61 85.372 38.011 3.68 34.056-42.359 35.447 9.922 11.856 41.714-34.906 48.773 23.353 6.677-13.944-49.375-23.641-3.924-36.316 61.815-68.654h93.109l37.164 57.171 12.961-8.426-36.867-56.714 46.097-79.842 56.949-8.452 13.579 45.092 14.803-4.459-12.928-42.927zm-341.203 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12.735-10.324 23.059-23.059 23.059-.769 0-1.528-.039-2.277-.113 4.196 5.718 10.962 9.432 18.598 9.432 12.735 0 23.059-10.324 23.059-23.059 0-11.966-9.116-21.802-20.782-22.946z" fill="#434343"/></g></g><g><g><circle cx="366.059" cy="396.021" fill="#fd7b65" r="23.059"/></g><g><path d="m368.336 373.075c2.802 3.818 4.461 8.528 4.461 13.627 0 12.735-10.324 23.059-23.059 23.059-.769 0-1.528-.039-2.277-.113 4.196 5.718 10.962 9.432 18.598 9.432 12.735 0 23.059-10.324 23.059-23.059 0-11.967-9.116-21.802-20.782-22.946z" fill="#fc534e"/></g></g></g></svg>--> </div> <p> <a class="tutorial-link" href="/help/structure-search"><span>Substructures and similarity</span></a> </p> </div> <div class="tutorial column-container"> <div class="tutorial-icon"> <img style="width: 45px; height: 45px; margin: 10px 10px 10px 15px" alt="go" src="/style/images/go-logo.png" /> </div> <p> <span class="tutorial-link"><span>Gene Ontology</span></span> <a href="https://youtu.be/uNYlMknEYok"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></a> </p> </div> <div class="tutorial column-container"> <div class="tutorial-icon"> <div class="ec"> <span>EC</span> </div> <!-- https://www.flaticon.com/free-icon/dna_3352657 --> <!-- <svg id="Capa_4" enable-background="new 0 0 497 497" viewBox="0 0 497 497" xmlns="http://www.w3.org/2000/svg"><g><g fill="#f7e365"><path d="m288.1 288.81-48.45 48.44c-6.63 6.63-16.76 7.26-22.61 1.4-5.86-5.85-5.23-15.98 1.4-22.61l48.45-48.44 15.129.881z"/><path d="m110.61 111.32-52.82 52.53c-5.87 5.84-15.37 5.81-21.21-.06-5.83-5.86-5.82-15.34.03-21.18l.03-.03 52.76-52.47 14.479.232z"/><path d="m405.48 406.18-53.74 53.74c-5.86 5.86-15.36 5.86-21.21 0-5.86-5.85-5.86-15.35 0-21.21l53.74-53.74 12.976-1.272z"/><path d="m231.53 232.24-48.45 48.44c-6.63 6.64-16.76 7.26-22.61 1.41-5.86-5.86-5.23-15.99 1.4-22.62l48.45-48.45 16.115 1.873z"/></g><g fill="#7894ab"><path d="m336.54 240.36-48.44 48.45-21.21-21.21 48.44-48.45c6.63-6.64 16.76-7.27 22.62-1.41s5.23 15.99-1.41 22.62z"/><path d="m163.41 58.82-.03.03-52.77 52.47-21.21-21.21 52.83-52.53c5.87-5.84 15.37-5.82 21.21.06 5.83 5.86 5.81 15.34-.03 21.18z"/><path d="m459.22 352.44-53.74 53.74-21.21-21.21 53.74-53.74c5.85-5.86 15.35-5.86 21.21 0s5.86 15.36 0 21.21z"/><path d="m279.98 183.79-48.45 48.45-21.21-21.22 48.44-48.44c6.64-6.64 16.76-7.27 22.62-1.41s5.23 15.99-1.4 22.62z"/></g><path d="m384.27 384.97h-.01"/><path d="m266.89 267.6-.01-.01"/><path d="m87.01 134.79-29.22 29.06c-5.87 5.84-15.37 5.81-21.21-.06-5.83-5.86-5.82-15.34.03-21.18l.03-.03 13.69-13.61c8.73 3.84 20.75 5.83 35.52 5.83.38 0 .77 0 1.16-.01z" fill="#f4d242"/><path d="m4.596 158.014c-6.051-6.051-6.137-15.772-.201-21.708s15.657-5.85 21.708.201c26.403 26.403 84.673 18.776 121.013 10.61l5.384 18.383-14.102 14.953c-45.846 8.466-101.656 9.707-133.802-22.439z" fill="#df646e"/><path d="m117.19 183.69c1.23-6.02 2.73-12.06 4.51-18.11 1.02-3.47 2.4-8.38 3.87-14.29 7.69-1.24 14.98-2.69 21.55-4.17-2.28 10.13-4.59 18.55-6.23 24.11-.91 3.08-1.74 6.16-2.49 9.22-6.88 1.27-13.99 2.38-21.21 3.24z" fill="#dc4955"/><path d="m264.52 312.39-24.87 24.86c-6.63 6.63-16.76 7.26-22.61 1.4-5.86-5.85-5.23-15.98 1.4-22.61l11.69-11.69c10.25 4.59 21.89 7.33 34.39 8.04z" fill="#f4d242"/><path d="m193.76 270-10.68 10.68c-6.63 6.64-16.76 7.26-22.61 1.41-5.86-5.86-5.23-15.99 1.4-22.62l22.45-22.45c1.25 12.1 4.43 23.23 9.44 32.98z" fill="#f4d242"/><path d="m163.41 58.82-.03.03-28.65 28.49c.14-14.48-1.54-27.25-5.61-36.72l13.11-13.04c5.87-5.84 15.37-5.82 21.21.06 5.83 5.86 5.81 15.34-.03 21.18z" fill="#5d748a"/><path d="m459.22 352.44-14.65 14.65c-8.78-3.45-20.46-5.24-34.59-5.24-.87 0-1.75.01-2.62.03l30.65-30.65c5.85-5.86 15.35-5.86 21.21 0s5.86 15.36 0 21.21z" fill="#5d748a"/><path d="m136.305 4.397c5.939-5.939 15.657-5.85 21.705.198 32.147 32.147 30.913 87.958 22.448 133.811-1.199 6.496 5.904 11.391 4.489 17.391-1.27 5.386-11.045 11.935-12.375 16.776-.743 2.704-1.487 5.311-2.223 7.811-3.418 11.612-5.513 23.07-6.227 34.058l-.082 1.256c-2.289 35.184 8.089 66.203 29.223 87.338 21.131 21.134 52.147 31.515 87.331 29.23 11.771-.765 23.801-2.911 35.754-6.377 47.183-13.678 132.796-30.163 176.058 13.1 6.048 6.048 6.137 15.766.198 21.705s-15.657 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13.469-10.925 24.394-24.394 24.394-10.349 0-19.194-6.446-22.726-15.539 1.277.206 2.585.309 3.913.309 13.479 0 24.394-10.915 24.394-24.394 0-3.13-.587-6.117-1.668-8.856 11.604 1.875 20.481 11.936 20.481 24.086z" fill="#e94444"/><path d="m171.717 316.3c0 13.479-10.925 24.394-24.394 24.394-10.349 0-19.184-6.436-22.726-15.528 1.277.206 2.585.309 3.913.309 13.479 0 24.394-10.925 24.394-24.394 0-3.13-.587-6.117-1.668-8.866 11.604 1.874 20.481 11.945 20.481 24.085z" fill="#e94444"/><path d="m409.564 188.191c0 13.469-10.925 24.394-24.394 24.394-10.359 0-19.204-6.446-22.736-15.549 1.277.216 2.585.319 3.923.319 13.469 0 24.394-10.915 24.394-24.394 0-3.13-.587-6.117-1.668-8.856 11.604 1.875 20.481 11.936 20.481 24.086z" fill="#e94444"/><path d="m409.564 316.3c0 13.479-10.925 24.394-24.394 24.394-10.349 0-19.204-6.436-22.736-15.539 1.277.216 2.585.319 3.923.319 13.469 0 24.394-10.925 24.394-24.394 0-3.13-.587-6.117-1.668-8.866 11.604 1.875 20.481 11.946 20.481 24.086z" fill="#e94444"/><path d="m290.074 113.299c0 13.469-10.915 24.394-24.394 24.394-10.349 0-19.194-6.446-22.726-15.549 1.277.216 2.585.319 3.923.319 13.469 0 24.394-10.915 24.394-24.394 0-3.12-.587-6.106-1.668-8.845 11.615 1.874 20.471 11.945 20.471 24.075z" fill="#e94444"/><path d="m290.074 389.164c0 13.469-10.915 24.394-24.394 24.394-10.349 0-19.194-6.446-22.726-15.549 1.277.216 2.585.319 3.923.319 13.469 0 24.394-10.915 24.394-24.394 0-3.12-.587-6.106-1.668-8.845 11.615 1.874 20.471 11.934 20.471 24.075z" fill="#e94444"/></g></svg>--> </div> <p> <span class="tutorial-link"><span>Enzymes (UniProt)</span></span> <a href="https://youtu.be/n8X2b4uwN0Y"><svg class="youtubeicon" viewBox="0 -77 512.00213 512" xmlns="http://www.w3.org/2000/svg"><path d="m501.453125 56.09375c-5.902344-21.933594-23.195313-39.222656-45.125-45.128906-40.066406-10.964844-200.332031-10.964844-200.332031-10.964844s-160.261719 0-200.328125 10.546875c-21.507813 5.902344-39.222657 23.617187-45.125 45.546875-10.542969 40.0625-10.542969 123.148438-10.542969 123.148438s0 83.503906 10.542969 123.148437c5.90625 21.929687 23.195312 39.222656 45.128906 45.128906 40.484375 10.964844 200.328125 10.964844 200.328125 10.964844s160.261719 0 200.328125-10.546875c21.933594-5.902344 39.222656-23.195312 45.128906-45.125 10.542969-40.066406 10.542969-123.148438 10.542969-123.148438s.421875-83.507812-10.546875-123.570312zm0 0" fill="#f00"/><path d="m204.96875 256 133.269531-76.757812-133.269531-76.757813zm0 0" fill="#fff"/></svg></a> </p> </div> </div> <div class="row-container" style="justify-content: right;"> <h6 style="font-weight: normal"> Icons made by <a href="http://www.freepik.com/" title="Freepik">Freepik</a> from <a href="https://www.flaticon.com/" title="Flaticon"> www.flaticon.com</a> </h6> </div> </div> </section> </main> <footer class="row-container" style="text-align: center;"> <div class="row-container footer-logo"> <img alt="SIB logo" width="70px" height="37px" src="/style/images/sib_logo_short.png" /> <span> <a 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