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Rougee</span>, <span class="highwire-citation-author" data-delta="1">Pooja V. Hegde</span>, <span class="highwire-citation-author" data-delta="2">Kaitlin Shin</span>, <span class="highwire-citation-author" data-delta="3">Trent L. Abraham</span>, <span class="highwire-citation-author" data-delta="4">Alec Bell</span> and <span class="highwire-citation-author" data-delta="5">Stephen D. Hall</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Drug Metabolism and Disposition </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 29, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">DMD-AR-2024-001820; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/dmd.124.001820 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/dmd/early/2024/10/29/dmd.124.001820.atom" data-type="link" data-font-icon="" data-parent-id="14640"></span></div> </div> </div></li><li class="odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node83434" data-node-nid="83434" id="node-83434--21637493859" data-pisa="dmd;dmd.124.001917v1" data-pisa-master="dmd;dmd.124.001917" data-apath="/dmd/early/2024/10/29/dmd.124.001917.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="dmd;dmd.124.001917" data-atom-uri="/dmd/early/2024/10/29/dmd.124.001917.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/29/dmd.124.001917" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Rei Sato</span>, <span class="highwire-citation-author" data-delta="1">Tatsuki Fukami</span>, <span class="highwire-citation-author" data-delta="2">Kazuya Shimomura</span>, <span class="highwire-citation-author" data-delta="3">Yongjie Zhang</span>, <span class="highwire-citation-author" data-delta="4">Masataka Nakano</span> and <span class="highwire-citation-author" data-delta="5">Miki Nakajima</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Drug Metabolism and Disposition </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 29, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">DMD-AR-2024-001917; 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Backes</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Drug Metabolism and Disposition </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 21, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">DMD-AR-2024-001939; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/dmd.124.001939 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/dmd/early/2024/10/21/dmd.124.001939.atom" data-type="link" data-font-icon="" data-parent-id="14640"></span></div> </div> </div></li></ul></div></div> </div> <div class="view-footer"> <div class="hw-pap-more-link text-right"> <a class="hw-view-more" href="/content/early/recent">View more <span class="element-invisible">published ahead of print articles</span><i class="icon-circle-arrow-right"></i></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-snippet" > <h2 class="pane-title">About Drug Metabolism &amp; 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Articles are added as they are ready and assigned to monthly issues. Check this site for new content or <a href="https://dmd.aspetjournals.org/alerts" target="_blank">sign up for content alerts</a>.</p> <h2><strong>EDITOR&#39;S CHOICE ARTICLES&nbsp;FOR NOVEMBER&nbsp;2024:</strong></h2> <ul> <li><a href="https://dmd.aspetjournals.org/content/52/11/1181" target="_blank">Characterizing the Distribution of a Stimulator of Interferon Genes Agonist and Its Metabolites in Mouse Liver by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry</a></li> <li><a href="https://dmd.aspetjournals.org/content/52/11/1356" target="_blank">Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I</a></li> </ul> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-mini pane-jnl-jpet-mc-read" > <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_mc_read"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-panels-ajax-tab-tabs" > <div class="pane-content"> <div class="item-list"><ul class="tabs inline panels-ajax-tab"><li class="first"><a href="" class="panels-ajax-tab-tab" data-panel-name="jnl_jpet_most_cited" data-target-id="jnl_jpet_most_cited_n_top_topics_panel" data-entity-context="none" data-trigger="" data-url-enabled="0">Most Cited</a><a href="/panels_ajax_tab/jnl_jpet_most_cited/none/0" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li class="last"><a href="" class="panels-ajax-tab-tab" data-panel-name="jnl_jpet_most_read" data-target-id="jnl_jpet_most_cited_n_top_topics_panel" data-entity-context="none" data-trigger="most-read" data-url-enabled="0">Most Read</a><a href="/panels_ajax_tab/jnl_jpet_most_read/none/0" rel="nofollow" style="display:none" class="js-crawler-link"></a></li></ul></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-ajax-tab-container" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_jpet_most_cited" id="panels-ajax-tab-container-jnl_jpet_most_cited_n_top_topics_panel" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://dmd.aspetjournals.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_jpet_most_cited"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-reports-feed" > <div class="pane-content"> <div class="highwire-list-wrapper highwire-article-citation-list"><div class="highwire-list"><ul class="highwire-feed-reports"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node17291" data-node-nid="17291" id="node-17291--2505268331" data-pisa="dmd;23/1/154" data-pisa-master="dmd;23/1/154" data-apath="/dmd/23/1/154.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard-title-only clearfix"> <a href="/content/23/1/154" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.</span></a> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node18500" data-node-nid="18500" id="node-18500--21903582571" data-pisa="dmd;27/11/1350" data-pisa-master="dmd;27/11/1350" data-apath="/dmd/27/11/1350.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard-title-only clearfix"> <a href="/content/27/11/1350" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes</span></a> </div> </div></li><li class="odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node20066" data-node-nid="20066" id="node-20066--2857547211" data-pisa="dmd;34/5/880" data-pisa-master="dmd;dmd.105.008672" data-apath="/dmd/34/5/880.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard-title-only clearfix"> <a href="/content/34/5/880" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”</span></a> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node19266" data-node-nid="19266" id="node-19266--2149178695" data-pisa="dmd;32/11/1201" data-pisa-master="dmd;dmd.104.000794" data-apath="/dmd/32/11/1201.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard-title-only clearfix"> <a href="/content/32/11/1201" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC<sub>I</sub>/AUC) RATIOS</span></a> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node18392" data-node-nid="18392" id="node-18392--2977874681" data-pisa="dmd;28/3/246" data-pisa-master="dmd;28/3/246" data-apath="/dmd/28/3/246.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard-title-only clearfix"> <a href="/content/28/3/246" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model</span></a> </div> </div></li></ul></div></div><div class="more-link"><a href="/articles/most-cited" class="link-more-articles" title="More..." data-icon-position="" data-hide-link-title="0">More...</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-mini pane-jnl-jpet-dfp-skyscraper-slot" > <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_dfp_skyscraper_slot"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-block pane-dfp-dmd-skyscraper-160x600 text-center pane-dfp" > <div class="pane-content"> <div id="dfp-ad-dmd_skyscraper_160x600-wrapper" class="dfp-tag-wrapper"><div class="slug">Advertisement</div> <div id="dfp-ad-dmd_skyscraper_160x600" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-dmd_skyscraper_160x600"); 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