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Nyirenda</title> <meta name="description" content="Search results for: Goodall Nyirenda"> <meta name="keywords" content="Goodall Nyirenda"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Goodall Nyirenda"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 5</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Goodall Nyirenda</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Evaluation of Clinical Decision Support System in Electronic Medical Record System: A Case of Malawi National Art Electronic Medical Record System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pachawo%20Bisani">Pachawo Bisani</a>, <a href="https://publications.waset.org/abstracts/search?q=Goodall%20Nyirenda"> Goodall Nyirenda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Malawi National Antiretroviral Therapy (NART) Electronic Medical Record (EMR) system was designed and developed with guidance from the Ministry of Health through the Department of HIV and AIDS (DHA) with the aim of supporting the management of HIV patient data and reporting in high prevalence ART clinics. As of 2021, the system has been scaled up to over 206 facilities across the country. The system is integrated with the clinical decision support system (CDSS) to assist healthcare providers in making a decision about an individual patient at a particular point in time. Despite NART EMR undergoing several evaluations and assessments, little has been done to evaluate the clinical decision support system in the NART EMR system. Hence, the study aimed to evaluate the use of CDSS in the NART EMR system in Malawi. The study adopted a mixed-method approach, and data was collected through interviews, observations, and questionnaires. The study has revealed that the CDSS tools were integrated into the ART clinic workflow, making it easy for the user to use it. The study has also revealed challenges in system reliability and information accuracy. Despite the challenges, the study further revealed that the system is effective and efficient, and overall, users are satisfied with the system. The study recommends that the implementers focus more on the logic behind the clinical decision-support intervention in order to address some of the concerns and enhance the accuracy of the information supplied. The study further suggests consulting the system's actual users throughout implementation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=clinical%20decision%20support%20system" title="clinical decision support system">clinical decision support system</a>, <a href="https://publications.waset.org/abstracts/search?q=electronic%20medical%20record%20system" title=" electronic medical record system"> electronic medical record system</a>, <a href="https://publications.waset.org/abstracts/search?q=usability" title=" usability"> usability</a>, <a href="https://publications.waset.org/abstracts/search?q=antiretroviral%20therapy" title=" antiretroviral therapy"> antiretroviral therapy</a> </p> <a href="https://publications.waset.org/abstracts/159450/evaluation-of-clinical-decision-support-system-in-electronic-medical-record-system-a-case-of-malawi-national-art-electronic-medical-record-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159450.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Hidden Markov Movement Modelling with Irregular Data</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Victoria%20Goodall">Victoria Goodall</a>, <a href="https://publications.waset.org/abstracts/search?q=Paul%20Fatti"> Paul Fatti</a>, <a href="https://publications.waset.org/abstracts/search?q=Norman%20Owen-Smith"> Norman Owen-Smith</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hidden Markov Models have become popular for the analysis of animal tracking data. These models are being used to model the movements of a variety of species in many areas around the world. A common assumption of the model is that the observations need to have regular time steps. In many ecological studies, this will not be the case. The objective of the research is to modify the movement model to allow for irregularly spaced locations and investigate the effect on the inferences which can be made about the latent states. A modification of the likelihood function to allow for these irregular spaced locations is investigated, without using interpolation or averaging the movement rate. The suitability of the modification is investigated using GPS tracking data for lion (Panthera leo) in South Africa, with many observations obtained during the night, and few observations during the day. Many nocturnal predator tracking studies are set up in this way, to obtain many locations at night when the animal is most active and is difficult to observe. Few observations are obtained during the day, when the animal is expected to rest and is potentially easier to observe. Modifying the likelihood function allows the popular Hidden Markov Model framework to be used to model these irregular spaced locations, making use of all the observed data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hidden%20Markov%20Models" title="hidden Markov Models">hidden Markov Models</a>, <a href="https://publications.waset.org/abstracts/search?q=irregular%20observations" title=" irregular observations"> irregular observations</a>, <a href="https://publications.waset.org/abstracts/search?q=animal%20movement%20modelling" title=" animal movement modelling"> animal movement modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=nocturnal%20predator" title=" nocturnal predator"> nocturnal predator</a> </p> <a href="https://publications.waset.org/abstracts/56744/hidden-markov-movement-modelling-with-irregular-data" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56744.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">244</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Production of Metal Matrix Composites with Diamond for Abrasive Cutting Resistance by Gas Infiltration Casting </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Haydar%20S.%20Al%20Shabbani">Haydar S. Al Shabbani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Marshall"> M. Marshall</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Goodall"> R. Goodall </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metal matrix composites (MMCs) have been explored for many applications for many decades. Recently, this includes investigations for thermal applications associated with electronics, such as in heat sinks. Here, to promote thermal conductivity, composites of a metal matrix with diamond particles are used. However, this class of composites has not yet been extensively examined for mechanical and tribological behavior, especially for applications that require extreme mechanical and tribological strength, such as the resistance to abrasive cutting. Therefore, this research seeks to develop a composite material with metal matrix and diamond particles which resist abrasive and cutting forces. The development progresses through a series of steps, exploring methods to process the material, understanding the mechanics of abrasive behavior and optimizing the composite structure to resist abrasive cutting. In processing, infiltration casting under gas pressure has been applied to molten aluminum to obtain a significant penetration of the metal into a preform of diamond particles. Different diamond particle sizes were used with different surface modifications (coated/uncoated), and to compare resulting composites with the same particle sizes. Al-1 wt.% Mg as a matrix alloy was utilised to investigate the possible effect of Mg on bonding phases during the infiltration process. The mechanical behavior and microstructure of the materials produced have been characterised. These tests showed that the surface modification of the diamond particles with a reactive material (Ti-coating) has an important role for enhancing the bonding between the aluminium matrix and diamond reinforcement as apparent under SEM observation. The effect of this improved bond is seen in the cutting resistance of the material. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aluminium" title="aluminium">aluminium</a>, <a href="https://publications.waset.org/abstracts/search?q=composites" title=" composites"> composites</a>, <a href="https://publications.waset.org/abstracts/search?q=diamond" title=" diamond"> diamond</a>, <a href="https://publications.waset.org/abstracts/search?q=Ti-coated" title=" Ti-coated"> Ti-coated</a>, <a href="https://publications.waset.org/abstracts/search?q=tribology" title=" tribology"> tribology</a> </p> <a href="https://publications.waset.org/abstracts/73320/production-of-metal-matrix-composites-with-diamond-for-abrasive-cutting-resistance-by-gas-infiltration-casting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/73320.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Control of Lymphatic Remodelling by miR-132</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Valeria%20Arcucci">Valeria Arcucci</a>, <a href="https://publications.waset.org/abstracts/search?q=Musarat%20Ishaq"> Musarat Ishaq</a>, <a href="https://publications.waset.org/abstracts/search?q=Steven%20A.%20Stacker"> Steven A. Stacker</a>, <a href="https://publications.waset.org/abstracts/search?q=Greg%20J.%20Goodall"> Greg J. Goodall</a>, <a href="https://publications.waset.org/abstracts/search?q=Marc%20G.%20Achen"> Marc G. Achen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metastasis is the lethal aspect of cancer for most patients. Remodelling of lymphatic vessels associated with a tumour is a key initial step in metastasis because it facilitates the entry of cancer cells into the lymphatic vasculature and their spread to lymph nodes and distant organs. Although it is clear that vascular endothelial growth factors (VEGFs), such as VEGF-C and VEGF-D, are key drivers of lymphatic remodelling, the means by which many signaling pathways in endothelial cells are coordinately regulated to drive growth and remodelling of lymphatics in cancer is not understood. We seek to understand the broader molecular mechanisms that control cancer metastasis, and are focusing on microRNAs, which coordinately regulate signaling pathways involved in complex biological responses in health and disease. Here, using small RNA sequencing, we found that a specific microRNA, miR-132, is upregulated in expression in lymphatic endothelial cells (LECs) in response to the lymphangiogenic growth factors. Interestingly, ectopic expression of miR-132 in LECs in vitro stimulated proliferation and tube formation of these cells. Moreover, miR-132 is expressed in lymphatic vessels of a subset of human breast tumours which were previously found to express high levels of VEGF-D by immunohistochemical analysis on tumour tissue microarrays. In order to dissect the complexity of regulation by miR-132 in lymphatic biology, we performed Argonaute HITS-CLIP, which led us to identify the miR-132-mRNA interactome in LECs. We found that this microRNA in LECs is involved in the control of many different pathways mainly involved in cell proliferation and regulation of the extracellular matrix and cell-cell junctions. We are now exploring the functional significance of miR-132 targets in the biology of LECs using biochemical techniques, functional in vitro cell assays and in vivo lymphangiogenesis assays. This project will ultimately define the molecular regulation of lymphatic remodelling by miR-132, and thereby identify potential therapeutic targets for drugs designed to restrict the growth and remodelling of tumour lymphatics resulting in metastatic spread. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=argonaute%20HITS-CLIP" title="argonaute HITS-CLIP">argonaute HITS-CLIP</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphatic%20remodelling" title=" lymphatic remodelling"> lymphatic remodelling</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-132" title=" miR-132"> miR-132</a>, <a href="https://publications.waset.org/abstracts/search?q=VEGF" title=" VEGF"> VEGF</a> </p> <a href="https://publications.waset.org/abstracts/110680/control-of-lymphatic-remodelling-by-mir-132" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/110680.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Techno Economic Analysis for Solar PV and Hydro Power for Kafue Gorge Power Station</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elvis%20Nyirenda">Elvis Nyirenda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research study work was done to evaluate and propose an optimum measure to enhance the uptake of clean energy technologies such as solar photovoltaics, the study also aims at enhancing the country鈥檚 energy mix from the overdependence on hydro power which is susceptible to droughts and climate change challenges The country in the years 2015 - 2016 and 2018 - 2019 had received rainfall below average due to climate change and a shift in the weather pattern; this resulted in prolonged power outages and load shedding for more than 10 hours per day. ZESCO Limited, the utility company that owns infrastructure in the generation, transmission, and distribution of electricity (state-owned), is seeking alternative sources of energy in order to reduce the over-dependence on hydropower stations. One of the alternative sources of energy is Solar Energy from the sun. However, solar power is intermittent in nature and to smoothen the load curve, investment in robust energy storage facilities is of great importance to enhance security and reliability of electricity supply in the country. The methodology of the study looked at the historical performance of the Kafue gorge upper power station and utilised the hourly generation figures as input data for generation modelling in Homer software. The average yearly demand was derived from the available data on the system SCADA. The two dams were modelled as natural battery with the absolute state of charging and discharging determined by the available water resource and the peak electricity demand. The software Homer Energy System is used to simulate the scheme incorporating a pumped storage facility and Solar photovoltaic systems. The pumped hydro scheme works like a natural battery for the conservation of water, with the only losses being evaporation and water leakages from the dams and the turbines. To address the problem of intermittency on the solar resource and the non-availability of water for hydropower generation, the study concluded that utilising the existing Hydro power stations, Kafue Gorge upper and Kafue Gorge Lower to work conjunctively with Solar energy will reduce power deficits and increase the security of supply for the country. An optimum capacity of 350MW of solar PV can be integrated while operating Kafue Gorge power station in both generating and pumping mode to enable efficient utilisation of water at Kafue Gorge upper Dam and Kafue Gorge Lower dam. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydropower" title="hydropower">hydropower</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20power%20systems" title=" solar power systems"> solar power systems</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20storage" title=" energy storage"> energy storage</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltaics" title=" photovoltaics"> photovoltaics</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20irradiation" title=" solar irradiation"> solar irradiation</a>, <a href="https://publications.waset.org/abstracts/search?q=pumped%20hydro%20storage%20system" title=" pumped hydro storage system"> pumped hydro storage system</a>, <a href="https://publications.waset.org/abstracts/search?q=supervisory%20control%20and%20data%20acquisition" title=" supervisory control and data acquisition"> supervisory control and data acquisition</a>, <a href="https://publications.waset.org/abstracts/search?q=Homer%20energy" title=" Homer energy"> Homer energy</a> </p> <a href="https://publications.waset.org/abstracts/159610/techno-economic-analysis-for-solar-pv-and-hydro-power-for-kafue-gorge-power-station" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159610.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">117</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div 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