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Modelos de regeneración

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class="content-xs bg-color-teal-light"> <div class="container"> <div class="row"> <div class="col-sm-12"> <h1 class="font-size-30 fweight-400 color-white">Revista de medicina regenerativa </h1> </div> </div> </div> </div> <nav class="navbar navbar-expand-lg bg-navbar navbar-light mega-menu journal-menu topbar-shadow" id="mainNavbar"> <div class="container"> <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-center" id="navbarSupportedContent"> <ul class="navbar-nav mb-auto mb-2 mb-lg-0"> <li class="nav-item"><a class="nav-link" href="https://spanish.scitechnol.com/journals/regenerative-medicine.html" title="haga clic aqu铆"><i class="fa fa-home" aria-hidden="true"></i></a></li> <li class="nav-item dropdown"> <a class="nav-link 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title="haga clic aqu铆">Enviar manuscrito</a></li> <li class="nav-item"><a class="nav-link" href="https://spanish.scitechnol.com/journals/archive-regenerative-medicine.html" title="haga clic aqu铆">Art铆culos</a></li> <li class="nav-item"><a class="nav-link" href="https://spanish.scitechnol.com/journals/guidelines-regenerative-medicine.html" title="haga clic aqu铆">Pautas</a></li> <li class="nav-item"><a class="nav-link" href="https://spanish.scitechnol.com/journals/indexing-regenerative-medicine.html" title="haga clic aqu铆">Indexaci贸n y archivo</a></li> <li class="nav-item"><a class="nav-link" href="https://spanish.scitechnol.com/contact.html" title="haga clic aqu铆">Contacto</a></li> </ul> </div> </div> </nav> </header> <div class="bg-color-sky-light"> <div class="content-md container border-bottom-1"> <div class="row"> <div class="col-sm-9"> <div class="margin-b-30"> <h2>Modelos de regeneraci&oacute;n</h2> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Podr&iacute;a decirse que la regeneraci&oacute;n es uno de los fen&oacute;menos biol&oacute;gicos m&aacute;s inspiradores que se sabe que existen. La historia del canon occidental est&aacute; poblada de muchos ejemplos del poder indiscriminado y poderoso que la regeneraci&oacute;n ha ejercido sobre la mente humana. Por ejemplo, cuando Lazzaro Spallanzani inform&oacute; en 1768 que los caracoles decapitados regeneraban sus cabezas, cient&iacute;ficos, fil&oacute;sofos y el p&uacute;blico en general recorrieron sus jardines en un intento de replicar este fascinante experimento (Odelberg, 2004). Tambi&eacute;n se descubri&oacute; que las salamandras pueden regenerar extremidades y colas (incluida la m&eacute;dula espinal), mientras que las planarias pueden regenerar animales enteros a partir de peque&ntilde;os fragmentos del cuerpo. A pesar del inter&eacute;s de larga data en este problema biol&oacute;gico y del conocimiento de que animales de todos los &aacute;mbitos de la vida realizan haza&ntilde;as regenerativas, todav&iacute;a estamos en las primeras etapas para describir estos eventos en t&eacute;rminos celulares, moleculares y mecanicistas. Sin embargo, las herramientas gen&eacute;ticas y moleculares para abordar el problema de la regeneraci&oacute;n est&aacute;n mejorando r&aacute;pidamente. Aparte de la curiosidad que normalmente suscita, el estudio y la comprensi&oacute;n de la regeneraci&oacute;n podr&iacute;an impactar dram&aacute;ticamente la pr&aacute;ctica de la medicina.</font></font></p> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Igual de relevante es el conocimiento derivado de la investigaci&oacute;n de las c&eacute;lulas madre, c&eacute;lulas indiferenciadas que tienen la capacidad de reemplazarse a s&iacute; mismas indefinidamente y de producir tipos celulares especializados. Mientras que las c&eacute;lulas madre embrionarias se dividen y, en &uacute;ltima instancia, dan lugar a todos los tipos de c&eacute;lulas diferenciadas del cuerpo, las c&eacute;lulas madre adultas de tejidos espec&iacute;ficos normalmente tienen un linaje restringido a un conjunto espec&iacute;fico de tipos de c&eacute;lulas. Para que un animal adulto reemplace las estructuras faltantes con una copia exacta de lo que falta, est&aacute; claro que se deben redistribuir programas de desarrollo. Sin embargo, la din&aacute;mica de la comunicaci&oacute;n y proliferaci&oacute;n celular es muy diferente, al igual que los tipos de c&eacute;lulas implicadas. Para lograr la regeneraci&oacute;n, los animales adultos pueden recurrir a la proliferaci&oacute;n de c&eacute;lulas diferenciadas, la activaci&oacute;n de c&eacute;lulas madre de reserva, la formaci&oacute;n de nuevas c&eacute;lulas madre con capacidad limitada para autorrenovarse (c&eacute;lulas progenitoras) o una combinaci&oacute;n de estas estrategias.</font></font></p> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">&iquest;Qu&eacute; c&eacute;lulas de un animal adulto se dividen y diferencian para reemplazar los m&uacute;ltiples tipos de c&eacute;lulas necesarios durante una respuesta regenerativa? Si bien se trata de una cuesti&oacute;n muy b&aacute;sica, de hecho fundamental, que ha sido formulada y reformulada a lo largo de sucesivas generaciones de bi&oacute;logos, su resistencia a los ataques experimentales ha resultado sorprendente y, en muchos casos, bastante frustrante. No obstante, es evidente que diferentes tejidos utilizan diferentes estrategias para lograr la reparaci&oacute;n o regeneraci&oacute;n del tejido. Por ejemplo, el h&iacute;gado de los vertebrados invoca una regeneraci&oacute;n compensatoria despu&eacute;s de la extirpaci&oacute;n de dos l&oacute;bulos, mediante la cual el l&oacute;bulo restante prolifera para volver a adquirir la masa de tejido original sin reemplazar los l&oacute;bulos faltantes. De hecho, la regeneraci&oacute;n puede ser compensatoria (h&iacute;gado), espec&iacute;fica de un tejido (coraz&oacute;n, m&uacute;sculo esquel&eacute;tico, h&iacute;gado, p&aacute;ncreas, cristalino, retina) o puede reconstruir estructuras complejas que contienen m&uacute;ltiples tipos de tejidos y &oacute;rganos (p. ej., extremidades, aletas, colas). . El objetivo de los investigadores que estudian organismos modelo de regeneraci&oacute;n es descubrir c&oacute;mo estos animales logran de forma natural la tarea aparentemente imposible de restaurar partes del cuerpo perdidas a causa de un trauma.</font></font></p> </div> </div> <!-- sidebar --> <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">Explorar SciTechnol</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://spanish.scitechnol.com/author-guidelines.html" title="haga clic aqu铆"> Pautas para el autor</a></li> <li class="color-base"><a href="https://spanish.scitechnol.com/reviewer-guidelines.html" title="haga clic aqu铆"> Directrices para el revisor</a></li> <li class="color-base"><a href="https://spanish.scitechnol.com/scitechnol-associations-indexing.html" title="haga clic aqu铆"> Asociaciones</a></li> <li class="color-base"><a 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