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subsection</span> </button> <ul id="toc-Expression_and_function-sublist" class="vector-toc-list"> <li id="toc-Extra-oral_roles_of_TAS2Rs" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extra-oral_roles_of_TAS2Rs"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Extra-oral roles of TAS2Rs</span> </div> </a> <ul id="toc-Extra-oral_roles_of_TAS2Rs-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Extra-oral_roles_of_TAS2R1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Extra-oral_roles_of_TAS2R1"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Extra-oral roles of TAS2R1</span> </div> </a> <ul id="toc-Extra-oral_roles_of_TAS2R1-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Structure_of_TAS2R1_receptor" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure_of_TAS2R1_receptor"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Structure of TAS2R1 receptor</span> </div> </a> <ul id="toc-Structure_of_TAS2R1_receptor-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gene" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Gene"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Gene</span> </div> </a> <button aria-controls="toc-Gene-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Gene subsection</span> </button> <ul id="toc-Gene-sublist" class="vector-toc-list"> <li id="toc-SNPs" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#SNPs"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>SNPs</span> </div> </a> <ul id="toc-SNPs-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Transcription_factors" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Transcription_factors"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Transcription factors</span> </div> </a> <ul id="toc-Transcription_factors-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mutagenesis_data" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mutagenesis_data"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Mutagenesis data</span> </div> </a> <ul id="toc-Mutagenesis_data-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Ligands" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Ligands"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Ligands</span> </div> </a> <ul id="toc-Ligands-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span 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lang="sr" hreflang="sr" data-title="TAS2R1" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/TAS2R1" title="TAS2R1 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="TAS2R1" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/TAS2R1" title="TAS2R1 – Tatar" lang="tt" hreflang="tt" data-title="TAS2R1" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/TAS2R1" title="TAS2R1 – Ukrainian" lang="uk" hreflang="uk" data-title="TAS2R1" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18039864#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/TAS2R1" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" 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<button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Member of the 25 known human bitter taste receptors</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">TAS2R1</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/14909">TAS2R1</a></span>, T2R1, TRB7, taste 2 receptor member 1</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/604796">604796</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:2681253">2681253</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=10480">10480</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS2R1">TAS2R1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000169777">TAS2R1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/450px-Ideogram_human_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/600px-Ideogram_human_chromosome_5.svg.png 2x" data-file-width="500" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_5_(human)" class="mw-redirect" title="Chromosome 5 (human)">Chromosome 5 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_5_ideogram.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/300px-Human_chromosome_5_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/450px-Human_chromosome_5_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/600px-Human_chromosome_5_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 10.267372907245px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for TAS2R1"><img alt="Genomic location for TAS2R1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 16.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for TAS2R1"><img alt="Genomic location for TAS2R1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">5p15.31</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">9,627,347 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">9,712,378 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_15.svg" class="mw-file-description" title="Chromosome 15 (mouse)"><img alt="Chromosome 15 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_15.svg/260px-Ideogram_house_mouse_chromosome_15.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_15.svg/390px-Ideogram_house_mouse_chromosome_15.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_15.svg/520px-Ideogram_house_mouse_chromosome_15.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 15 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_15.svg" class="mw-file-description" title="Chromosome 15 (mouse)"><img alt="Chromosome 15 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Ideogram_of_house_mouse_chromosome_15.svg/300px-Ideogram_of_house_mouse_chromosome_15.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Ideogram_of_house_mouse_chromosome_15.svg/450px-Ideogram_of_house_mouse_chromosome_15.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/77/Ideogram_of_house_mouse_chromosome_15.svg/600px-Ideogram_of_house_mouse_chromosome_15.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 85.5675558519px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for TAS2R1"><img alt="Genomic location for TAS2R1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 91.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for TAS2R1"><img alt="Genomic location for TAS2R1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">15|15 B3.1</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">32,177,435 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">32,178,440 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000169777">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right testis</li><br /><li style="line-height: 137%;">left testis</li><br /><li style="line-height: 137%;">stromal cell of endometrium</li><br /><li style="line-height: 137%;">epithelium of colon</li><br /><li style="line-height: 137%;">placenta</li><br /><li style="line-height: 137%;">caudate nucleus</li><br /><li style="line-height: 137%;">putamen</li><br /><li style="line-height: 137%;">nucleus accumbens</li><br /><li style="line-height: 137%;">hippocampal formation</li><br /><li style="line-height: 137%;">prefrontal cortex</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000045267">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">proximal tubule</li><br /><li style="line-height: 137%;">right kidney</li><br /><li style="line-height: 137%;">genital tubercle</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000169777">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_TAS2R1_221324_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PBB_GE_TAS2R1_221324_at_fs.png/250px-PBB_GE_TAS2R1_221324_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PBB_GE_TAS2R1_221324_at_fs.png/375px-PBB_GE_TAS2R1_221324_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/PBB_GE_TAS2R1_221324_at_fs.png/500px-PBB_GE_TAS2R1_221324_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/50834/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004930">G protein-coupled receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008527">taste receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033038">bitter taste receptor activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001580">detection of chemical stimulus involved in sensory perception of bitter taste</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050896">response to stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050909">sensory perception of taste</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=50834&rn=1">50834</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=57254&rn=1">57254</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000169777;db=core">ENSG00000169777</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000045267;db=core">ENSMUSG00000045267</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9NYW7">Q9NYW7</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9JKT2">Q9JKT2</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_019599">NM_019599</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001386348">NM_001386348</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_020503">NM_020503</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_062545">NP_062545</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_065249">NP_065249</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr5:9627347-9712378">Chr 5: 9.63 – 9.71 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr15:32177435-32178440">Chr 15: 32.18 – 32.18 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18039864" class="extiw" title="d:Q18039864">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18258693" class="extiw" title="d:Q18258693">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Taste receptor type 2 member 1 (TAS2R1/T2R1)</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>TAS2R1</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid10761934_5-0" class="reference"><a href="#cite_note-pmid10761934-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10766242_6-0" class="reference"><a href="#cite_note-pmid10766242-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It belongs to the <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a> (GPCR) family and is related to <a href="/wiki/GPCR_family_A" class="mw-redirect" title="GPCR family A">class A</a>-like GPCRs, they contain 7 transmembrane helix bundles and short <a href="/wiki/N-terminus" title="N-terminus">N-terminus</a> loop.<sup id="cite_ref-Di_Pizio_2016_8-0" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the <a href="/wiki/Bitter_taste_evolution" title="Bitter taste evolution">perception of bitter taste</a> in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.<sup id="cite_ref-Lu_2017_9-0" class="reference"><a href="#cite_note-Lu_2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Expression_and_function">Expression and function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=1" title="Edit section: Expression and function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Extra-oral_roles_of_TAS2Rs">Extra-oral roles of TAS2Rs</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=2" title="Edit section: Extra-oral roles of TAS2Rs"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bitter taste receptors are expressed in <a href="/wiki/Taste_receptor" title="Taste receptor">taste receptor cells</a>, which organized into <a href="/wiki/Taste_bud" title="Taste bud">taste buds</a> on the papillae of the <a href="/wiki/Tongue" title="Tongue">tongue</a> and palate epithelium. </p><p>In addition, TAS2Rs were found to be expressed in extra-oral tissues, e.g. brain, lungs, gastrointestinal tract, etc.<sup id="cite_ref-Lu_2017_9-1" class="reference"><a href="#cite_note-Lu_2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> So far, less is known about their function however, for example it was shown that: </p> <ul><li>TAS2Rs mediate relaxation of airway smooth muscles.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li>TAS2R43 is involved in secretion of gastric acid in the stomach.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Extra-oral_roles_of_TAS2R1">Extra-oral roles of TAS2R1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=3" title="Edit section: Extra-oral roles of TAS2R1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>TAS2R1, TAS2R4, TAS2R10, TAS2R38 and TAS2R49 were found to be down-regulated in <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a> cells<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><i>.</i></li> <li>TAS2R1, causes vasoconstrictor responses in the <a href="/wiki/Pulmonary_circulation" title="Pulmonary circulation">pulmonary circuit</a> and relaxation in the airways<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><i>.</i></li></ul> <div class="mw-heading mw-heading2"><h2 id="Structure_of_TAS2R1_receptor">Structure of TAS2R1 receptor</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=4" title="Edit section: Structure of TAS2R1 receptor"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Based on a recent <a href="/wiki/Homology_modeling" title="Homology modeling">homology model</a> from <a rel="nofollow" class="external text" href="http://bitterdb.agri.huji.ac.il/Receptor.php?mode_organism=default&id=1">BitterDB</a><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> several conserved <a href="/wiki/Structural_motif" title="Structural motif">motifs</a>, which are counterparts to Class A GPCRs<sup id="cite_ref-Di_Pizio_2016_8-1" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> were found: </p> <ul><li>Transmembrane helix 1: N<sup>1.50</sup>xxI<sup>1.53</sup></li> <li>Transmembrane helix 2: L<sup>2.46</sup>xxxR<sup>2.50</sup></li> <li>Transmembrane helix 3: F<sup>3.49</sup>Y<sup>3.50</sup>xxK<sup>3.53</sup></li> <li>Transmembrane helix 5: P<sup>5.50</sup></li> <li>Transmembrane helix 6: F<sup>6.44</sup>xxxY<sup>6.46</sup></li> <li>Transmembrane helix 7: H<sup>7.49</sup>S<sup>7.50</sup>xxL<sup>7.53</sup></li></ul> <p>Numbering is according to the Balleros-Weinstein system<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>Unlike in Class A GPCRs, in transmembrane helix 4 no DRY<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> motif was found as well as position 6.50 is not conserved. </p> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=5" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>This gene encodes a member of a family of candidate <a href="/wiki/Taste_receptor" title="Taste receptor">taste receptors</a> that are members of the <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a> superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. </p> <div class="mw-heading mw-heading3"><h3 id="SNPs">SNPs</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=6" title="Edit section: SNPs"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In T2R1 two <a href="/wiki/Single-nucleotide_polymorphism" title="Single-nucleotide polymorphism">SNPs</a> are known in R111H and R206W (<a href="/wiki/DbSNP" title="DbSNP">dbSNP</a>). </p> <div class="mw-heading mw-heading3"><h3 id="Transcription_factors">Transcription factors</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=7" title="Edit section: Transcription factors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>So far, AML1a, AP-1, AREB6, FOXL1, IRF-7A, Lmo2, NF-E2, NF-E2 p45 were found as the top <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> binding sites by QIAGEN in the <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS2R1"><i>TAS2R1</i> gene promoter</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Mutagenesis_data">Mutagenesis data</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=8" title="Edit section: Mutagenesis data"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Several <a href="/wiki/Mutation" title="Mutation">mutations</a> have been shown to influence binding of a ligand to TAS2R1 (based on <a rel="nofollow" class="external text" href="http://bitterdb.agri.huji.ac.il/Receptor.php?mode_organism=default&id=1">BitterDB</a>): </p> <table class="wikitable"> <tbody><tr> <td>Receptor region </td> <td>BW number </td> <td>Residue </td> <td>Reference </td></tr> <tr> <td>TM1 </td> <td>1.5 </td> <td>N24 </td> <td><sup id="cite_ref-Sandal_2015_18-0" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-0" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM1 </td> <td>1.53 </td> <td>I27 </td> <td><sup id="cite_ref-Sandal_2015_18-1" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-1" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM2 </td> <td>2.5 </td> <td>R55 </td> <td><sup id="cite_ref-Sandal_2015_18-2" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-2" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM2 </td> <td>2.56 </td> <td>F61 </td> <td><sup id="cite_ref-Singh_2011_19-3" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM2 </td> <td>2.61 </td> <td>N66 </td> <td><sup id="cite_ref-Fierro_2017_20-0" class="reference"><a href="#cite_note-Fierro_2017-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Sandal_2015_18-3" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Di_Pizio_2016_8-2" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-4" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>ECL1 </td> <td> </td> <td>E74 </td> <td><sup id="cite_ref-Fierro_2017_20-1" class="reference"><a href="#cite_note-Fierro_2017-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.32 </td> <td>L85 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-3" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dai_2011_21-0" class="reference"><a href="#cite_note-Dai_2011-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.33 </td> <td>L86 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-4" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dai_2011_21-1" class="reference"><a href="#cite_note-Dai_2011-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.36 </td> <td>N89 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-5" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-5" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Sandal_2015_18-4" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.37 </td> <td>E90 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-6" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dai_2011_21-2" class="reference"><a href="#cite_note-Dai_2011-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.41 </td> <td>W94 </td> <td><sup id="cite_ref-Sandal_2015_18-5" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-6" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM3 </td> <td>3.46 </td> <td>L99 </td> <td><sup id="cite_ref-Sandal_2015_18-6" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-7" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM5 </td> <td>5.46 </td> <td>E182 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-7" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dai_2011_21-3" class="reference"><a href="#cite_note-Dai_2011-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM5 </td> <td>5.61 </td> <td>L197 </td> <td><sup id="cite_ref-Sandal_2015_18-7" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-8" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM5 </td> <td>5.64 </td> <td>S200 </td> <td><sup id="cite_ref-Sandal_2015_18-8" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-9" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM5 </td> <td>5.65 </td> <td>L201 </td> <td><sup id="cite_ref-Sandal_2015_18-9" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-10" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM7 </td> <td>7.39 </td> <td>I263 </td> <td><sup id="cite_ref-Di_Pizio_2016_8-8" class="reference"><a href="#cite_note-Di_Pizio_2016-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dai_2011_21-4" class="reference"><a href="#cite_note-Dai_2011-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM7 </td> <td>7.49 </td> <td>H273 </td> <td><sup id="cite_ref-Sandal_2015_18-10" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-11" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM7 </td> <td>7.53 </td> <td>L277 </td> <td><sup id="cite_ref-Sandal_2015_18-11" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-12" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>TM7 </td> <td>7.54 </td> <td>I278 </td> <td><sup id="cite_ref-Sandal_2015_18-12" class="reference"><a href="#cite_note-Sandal_2015-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Singh_2011_19-13" class="reference"><a href="#cite_note-Singh_2011-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Ligands">Ligands</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=9" title="Edit section: Ligands"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Up to now, 39 ligands for T2R1 were identified in <a href="/wiki/BitterDB" title="BitterDB">BitterDB</a>, among them <a href="/wiki/Amino_acid" title="Amino acid">L-amino acids</a>, <a href="/wiki/Peptide" title="Peptide">peptides</a>, <a href="/wiki/Humulone" title="Humulone">humulones</a>, small molecules etc.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=10" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Taste_receptor" title="Taste receptor">Taste receptor</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000169777">GRCh38: Ensembl release 89: ENSG00000169777</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000045267">GRCm38: Ensembl release 89: ENSMUSG00000045267</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=50834">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D50834&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=57254">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D57254&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-pmid10761934-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10761934_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAdlerHoonMuellerChandrashekar2000" class="citation journal cs1">Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980705-9">"A novel family of mammalian taste receptors"</a>. <i>Cell</i>. <b>100</b> (6): <span class="nowrap">693–</span>702. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980705-9">10.1016/S0092-8674(00)80705-9</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10761934">10761934</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:14604586">14604586</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=A+novel+family+of+mammalian+taste+receptors&rft.volume=100&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E693-%3C%2Fspan%3E702&rft.date=2000-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A14604586%23id-name%3DS2CID&rft_id=info%3Apmid%2F10761934&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2800%2980705-9&rft.aulast=Adler&rft.aufirst=E&rft.au=Hoon%2C+MA&rft.au=Mueller%2C+KL&rft.au=Chandrashekar%2C+J&rft.au=Ryba%2C+NJ&rft.au=Zuker%2C+CS&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252800%252980705-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-pmid10766242-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10766242_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMatsunamiMontmayeurBuck2000" class="citation journal cs1">Matsunami H, Montmayeur JP, Buck LB (April 2000). "A family of candidate taste receptors in human and mouse". <i>Nature</i>. <b>404</b> (6778): <span class="nowrap">601–</span>604. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000Natur.404..601M">2000Natur.404..601M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35007072">10.1038/35007072</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10766242">10766242</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4336913">4336913</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=A+family+of+candidate+taste+receptors+in+human+and+mouse&rft.volume=404&rft.issue=6778&rft.pages=%3Cspan+class%3D%22nowrap%22%3E601-%3C%2Fspan%3E604&rft.date=2000-04&rft_id=info%3Adoi%2F10.1038%2F35007072&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4336913%23id-name%3DS2CID&rft_id=info%3Apmid%2F10766242&rft_id=info%3Abibcode%2F2000Natur.404..601M&rft.aulast=Matsunami&rft.aufirst=H&rft.au=Montmayeur%2C+JP&rft.au=Buck%2C+LB&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-entrez_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50834">"Entrez Gene: TAS2R1 taste receptor, type 2, member 1"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+TAS2R1+taste+receptor%2C+type+2%2C+member+1&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D50834&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Di_Pizio_2016-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-Di_Pizio_2016_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Di_Pizio_2016_8-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDi_PizioLevitSlutzkiBehrens2016" class="citation book cs1">Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY (2016). "Comparing Class a GPCRS to bitter taste receptors". <i>Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios</i>. Methods in Cell Biology. Vol. 132. Elsevier. pp. <span class="nowrap">401–</span>427. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fbs.mcb.2015.10.005">10.1016/bs.mcb.2015.10.005</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-803595-5" title="Special:BookSources/978-0-12-803595-5"><bdi>978-0-12-803595-5</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26928553">26928553</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Comparing+Class+a+GPCRS+to+bitter+taste+receptors&rft.btitle=Comparing+Class+A+GPCRs+to+bitter+taste+receptors%3A+Structural+motifs%2C+ligand+interactions+and+agonist-to-antagonist+ratios&rft.series=Methods+in+Cell+Biology&rft.pages=%3Cspan+class%3D%22nowrap%22%3E401-%3C%2Fspan%3E427&rft.pub=Elsevier&rft.date=2016&rft_id=info%3Apmid%2F26928553&rft_id=info%3Adoi%2F10.1016%2Fbs.mcb.2015.10.005&rft.isbn=978-0-12-803595-5&rft.aulast=Di+Pizio&rft.aufirst=A&rft.au=Levit%2C+A&rft.au=Slutzki%2C+M&rft.au=Behrens%2C+M&rft.au=Karaman%2C+R&rft.au=Niv%2C+MY&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Lu_2017-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-Lu_2017_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Lu_2017_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLuZhangLifshitzZhuGe2017" class="citation journal cs1">Lu P, Zhang CH, Lifshitz LM, ZhuGe R (February 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299619">"Extraoral bitter taste receptors in health and disease"</a>. <i>The Journal of General Physiology</i>. <b>149</b> (2): <span class="nowrap">181–</span>197. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1085%2Fjgp.201611637">10.1085/jgp.201611637</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299619">5299619</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28053191">28053191</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+General+Physiology&rft.atitle=Extraoral+bitter+taste+receptors+in+health+and+disease&rft.volume=149&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E181-%3C%2Fspan%3E197&rft.date=2017-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5299619%23id-name%3DPMC&rft_id=info%3Apmid%2F28053191&rft_id=info%3Adoi%2F10.1085%2Fjgp.201611637&rft.aulast=Lu&rft.aufirst=P&rft.au=Zhang%2C+CH&rft.au=Lifshitz%2C+LM&rft.au=ZhuGe%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5299619&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDeshpandeWangMcIlmoyleRobinett2010" class="citation journal cs1">Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, et al. (November 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066567">"Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction"</a>. <i>Nature Medicine</i>. <b>16</b> (11): <span class="nowrap">1299–</span>1304. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnm.2237">10.1038/nm.2237</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066567">3066567</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20972434">20972434</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Bitter+taste+receptors+on+airway+smooth+muscle+bronchodilate+by+localized+calcium+signaling+and+reverse+obstruction&rft.volume=16&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1299-%3C%2Fspan%3E1304&rft.date=2010-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3066567%23id-name%3DPMC&rft_id=info%3Apmid%2F20972434&rft_id=info%3Adoi%2F10.1038%2Fnm.2237&rft.aulast=Deshpande&rft.aufirst=DA&rft.au=Wang%2C+WC&rft.au=McIlmoyle%2C+EL&rft.au=Robinett%2C+KS&rft.au=Schillinger%2C+RM&rft.au=An%2C+SS&rft.au=Sham%2C+JS&rft.au=Liggett%2C+SB&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3066567&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLisztLeyLiederBehrens2017" class="citation journal cs1">Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, et al. (July 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544304">"Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>114</b> (30): <span class="nowrap">E6260 –</span> <span class="nowrap">E6269</span>. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2017PNAS..114E6260L">2017PNAS..114E6260L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1703728114">10.1073/pnas.1703728114</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544304">5544304</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28696284">28696284</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Caffeine+induces+gastric+acid+secretion+via+bitter+taste+signaling+in+gastric+parietal+cells&rft.volume=114&rft.issue=30&rft.pages=%3Cspan+class%3D%22nowrap%22%3EE6260+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3EE6269%3C%2Fspan%3E&rft.date=2017-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5544304%23id-name%3DPMC&rft_id=info%3Apmid%2F28696284&rft_id=info%3Adoi%2F10.1073%2Fpnas.1703728114&rft_id=info%3Abibcode%2F2017PNAS..114E6260L&rft.aulast=Liszt&rft.aufirst=KI&rft.au=Ley%2C+JP&rft.au=Lieder%2C+B&rft.au=Behrens%2C+M&rft.au=St%C3%B6ger%2C+V&rft.au=Reiner%2C+A&rft.au=Hochkogler%2C+CM&rft.au=K%C3%B6ck%2C+E&rft.au=Marchiori%2C+A&rft.au=Hans%2C+J&rft.au=Widder%2C+S&rft.au=Krammer%2C+G&rft.au=Sanger%2C+GJ&rft.au=Somoza%2C+MM&rft.au=Meyerhof%2C+W&rft.au=Somoza%2C+V&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5544304&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSinghChakrabortyBhullarChelikani2014" class="citation journal cs1">Singh N, Chakraborty R, Bhullar RP, Chelikani P (April 2014). "Differential expression of bitter taste receptors in non-cancerous breast epithelial and breast cancer cells". <i>Biochemical and Biophysical Research Communications</i>. <b>446</b> (2): <span class="nowrap">499–</span>503. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbrc.2014.02.140">10.1016/j.bbrc.2014.02.140</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24613843">24613843</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Differential+expression+of+bitter+taste+receptors+in+non-cancerous+breast+epithelial+and+breast+cancer+cells&rft.volume=446&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E499-%3C%2Fspan%3E503&rft.date=2014-04&rft_id=info%3Adoi%2F10.1016%2Fj.bbrc.2014.02.140&rft_id=info%3Apmid%2F24613843&rft.aulast=Singh&rft.aufirst=N&rft.au=Chakraborty%2C+R&rft.au=Bhullar%2C+RP&rft.au=Chelikani%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFUpadhyayaSinghSikarwarChakraborty2014" class="citation journal cs1">Upadhyaya JD, Singh N, Sikarwar AS, Chakraborty R, Pydi SP, Bhullar RP, et al. (2014-10-23). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207743">"Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction"</a>. <i>PLOS ONE</i>. <b>9</b> (10): e110373. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2014PLoSO...9k0373U">2014PLoSO...9k0373U</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0110373">10.1371/journal.pone.0110373</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207743">4207743</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25340739">25340739</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=Dextromethorphan+mediated+bitter+taste+receptor+activation+in+the+pulmonary+circuit+causes+vasoconstriction&rft.volume=9&rft.issue=10&rft.pages=e110373&rft.date=2014-10-23&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4207743%23id-name%3DPMC&rft_id=info%3Apmid%2F25340739&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0110373&rft_id=info%3Abibcode%2F2014PLoSO...9k0373U&rft.aulast=Upadhyaya&rft.aufirst=JD&rft.au=Singh%2C+N&rft.au=Sikarwar%2C+AS&rft.au=Chakraborty%2C+R&rft.au=Pydi%2C+SP&rft.au=Bhullar%2C+RP&rft.au=Dakshinamurti%2C+S&rft.au=Chelikani%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4207743&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWienerShudlerLevitNiv2012" class="citation journal cs1">Wiener A, Shudler M, Levit A, Niv MY (January 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245057">"BitterDB: a database of bitter compounds"</a>. <i>Nucleic Acids Research</i>. <b>40</b> (Database issue): <span class="nowrap">D413 –</span> <span class="nowrap">D419</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkr755">10.1093/nar/gkr755</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245057">3245057</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21940398">21940398</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=BitterDB%3A+a+database+of+bitter+compounds&rft.volume=40&rft.issue=Database+issue&rft.pages=%3Cspan+class%3D%22nowrap%22%3ED413+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3ED419%3C%2Fspan%3E&rft.date=2012-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3245057%23id-name%3DPMC&rft_id=info%3Apmid%2F21940398&rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgkr755&rft.aulast=Wiener&rft.aufirst=A&rft.au=Shudler%2C+M&rft.au=Levit%2C+A&rft.au=Niv%2C+MY&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3245057&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDagan-WienerDi_PizioNissimBahia2019" class="citation journal cs1">Dagan-Wiener A, Di Pizio A, Nissim I, Bahia MS, Dubovski N, Margulis E, et al. (January 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323989">"BitterDB: taste ligands and receptors database in 2019"</a>. <i>Nucleic Acids Research</i>. <b>47</b> (D1): <span class="nowrap">D1179 –</span> <span class="nowrap">D1185</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgky974">10.1093/nar/gky974</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323989">6323989</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30357384">30357384</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=BitterDB%3A+taste+ligands+and+receptors+database+in+2019&rft.volume=47&rft.issue=D1&rft.pages=%3Cspan+class%3D%22nowrap%22%3ED1179+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3ED1185%3C%2Fspan%3E&rft.date=2019-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6323989%23id-name%3DPMC&rft_id=info%3Apmid%2F30357384&rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgky974&rft.aulast=Dagan-Wiener&rft.aufirst=A&rft.au=Di+Pizio%2C+A&rft.au=Nissim%2C+I&rft.au=Bahia%2C+MS&rft.au=Dubovski%2C+N&rft.au=Margulis%2C+E&rft.au=Niv%2C+MY&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6323989&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBallesterosWeinstein1995" class="citation book cs1">Ballesteros JA, Weinstein H (1995). "Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors". <i>Receptor Molecular Biology</i>. Methods in Neurosciences. Vol. 25. Elsevier. pp. <span class="nowrap">366–</span>428. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs1043-9471%2805%2980049-7">10.1016/s1043-9471(05)80049-7</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-185295-5" title="Special:BookSources/978-0-12-185295-5"><bdi>978-0-12-185295-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Integrated+methods+for+the+construction+of+three-dimensional+models+and+computational+probing+of+structure-function+relations+in+G+protein-coupled+receptors&rft.btitle=Receptor+Molecular+Biology&rft.series=Methods+in+Neurosciences&rft.pages=%3Cspan+class%3D%22nowrap%22%3E366-%3C%2Fspan%3E428&rft.pub=Elsevier&rft.date=1995&rft_id=info%3Adoi%2F10.1016%2Fs1043-9471%2805%2980049-7&rft.isbn=978-0-12-185295-5&rft.aulast=Ballesteros&rft.aufirst=JA&rft.au=Weinstein%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRovatiCapraNeubig2007" class="citation journal cs1">Rovati GE, Capra V, Neubig RR (April 2007). "The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state". <i>Molecular Pharmacology</i>. <b>71</b> (4): <span class="nowrap">959–</span>964. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fmol.106.029470">10.1124/mol.106.029470</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17192495">17192495</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:15536186">15536186</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=The+highly+conserved+DRY+motif+of+class+A+G+protein-coupled+receptors%3A+beyond+the+ground+state&rft.volume=71&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E959-%3C%2Fspan%3E964&rft.date=2007-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A15536186%23id-name%3DS2CID&rft_id=info%3Apmid%2F17192495&rft_id=info%3Adoi%2F10.1124%2Fmol.106.029470&rft.aulast=Rovati&rft.aufirst=GE&rft.au=Capra%2C+V&rft.au=Neubig%2C+RR&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Sandal_2015-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-Sandal_2015_18-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-Sandal_2015_18-12"><sup><i><b>m</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSandalBehrensBrockhoffMusiani2015" class="citation journal cs1">Sandal M, Behrens M, Brockhoff A, Musiani F, Giorgetti A, Carloni P, et al. (September 2015). "Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor". <i>Journal of Chemical Theory and Computation</i>. <b>11</b> (9): <span class="nowrap">4439–</span>4449. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Facs.jctc.5b00472">10.1021/acs.jctc.5b00472</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26575934">26575934</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Chemical+Theory+and+Computation&rft.atitle=Evidence+for+a+Transient+Additional+Ligand+Binding+Site+in+the+TAS2R46+Bitter+Taste+Receptor&rft.volume=11&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E4439-%3C%2Fspan%3E4449&rft.date=2015-09&rft_id=info%3Adoi%2F10.1021%2Facs.jctc.5b00472&rft_id=info%3Apmid%2F26575934&rft.aulast=Sandal&rft.aufirst=M&rft.au=Behrens%2C+M&rft.au=Brockhoff%2C+A&rft.au=Musiani%2C+F&rft.au=Giorgetti%2C+A&rft.au=Carloni%2C+P&rft.au=Meyerhof%2C+W&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Singh_2011-19"><span class="mw-cite-backlink">^ <a href="#cite_ref-Singh_2011_19-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-Singh_2011_19-13"><sup><i><b>n</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSinghPydiUpadhyayaChelikani2011" class="citation journal cs1">Singh N, Pydi SP, Upadhyaya J, Chelikani P (October 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195589">"Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs)"</a>. <i>The Journal of Biological Chemistry</i>. <b>286</b> (41): <span class="nowrap">36032–</span>36041. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M111.246983">10.1074/jbc.M111.246983</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195589">3195589</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21852241">21852241</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Structural+basis+of+activation+of+bitter+taste+receptor+T2R1+and+comparison+with+Class+A+G-protein-coupled+receptors+%28GPCRs%29&rft.volume=286&rft.issue=41&rft.pages=%3Cspan+class%3D%22nowrap%22%3E36032-%3C%2Fspan%3E36041&rft.date=2011-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3195589%23id-name%3DPMC&rft_id=info%3Apmid%2F21852241&rft_id=info%3Adoi%2F10.1074%2Fjbc.M111.246983&rft.aulast=Singh&rft.aufirst=N&rft.au=Pydi%2C+SP&rft.au=Upadhyaya%2C+J&rft.au=Chelikani%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3195589&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Fierro_2017-20"><span class="mw-cite-backlink">^ <a href="#cite_ref-Fierro_2017_20-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Fierro_2017_20-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFFierroSukuAlfonso-PrietoGiorgetti2017" class="citation journal cs1">Fierro F, Suku E, Alfonso-Prieto M, Giorgetti A, Cichon S, Carloni P (2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592726">"Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis"</a>. <i>Frontiers in Molecular Biosciences</i>. <b>4</b>: 63. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffmolb.2017.00063">10.3389/fmolb.2017.00063</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592726">5592726</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28932739">28932739</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Frontiers+in+Molecular+Biosciences&rft.atitle=Agonist+Binding+to+Chemosensory+Receptors%3A+A+Systematic+Bioinformatics+Analysis&rft.volume=4&rft.pages=63&rft.date=2017&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5592726%23id-name%3DPMC&rft_id=info%3Apmid%2F28932739&rft_id=info%3Adoi%2F10.3389%2Ffmolb.2017.00063&rft.aulast=Fierro&rft.aufirst=F&rft.au=Suku%2C+E&rft.au=Alfonso-Prieto%2C+M&rft.au=Giorgetti%2C+A&rft.au=Cichon%2C+S&rft.au=Carloni%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5592726&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-Dai_2011-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-Dai_2011_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Dai_2011_21-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Dai_2011_21-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Dai_2011_21-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Dai_2011_21-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDaiYouZhouZhang2011" class="citation journal cs1">Dai W, You Z, Zhou H, Zhang J, Hu Y (June 2011). "Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies". <i>Journal of Receptor and Signal Transduction Research</i>. <b>31</b> (3): <span class="nowrap">229–</span>40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F10799893.2011.578141">10.3109/10799893.2011.578141</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21619450">21619450</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Receptor+and+Signal+Transduction+Research&rft.atitle=Structure-function+relationships+of+the+human+bitter+taste+receptor+hTAS2R1%3A+insights+from+molecular+modeling+studies&rft.volume=31&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E229-%3C%2Fspan%3E40&rft.date=2011-06&rft_id=info%3Adoi%2F10.3109%2F10799893.2011.578141&rft_id=info%3Apmid%2F21619450&rft.aulast=Dai&rft.aufirst=W&rft.au=You%2C+Z&rft.au=Zhou%2C+H&rft.au=Zhang%2C+J&rft.au=Hu%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://bitterdb.agri.huji.ac.il/Receptor.php?id=1">"hTAS2R1"</a>. <i>BitterDB</i>. The Hebrew University of Jerusalem.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=BitterDB&rft.atitle=hTAS2R1&rft_id=http%3A%2F%2Fbitterdb.agri.huji.ac.il%2FReceptor.php%3Fid%3D1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=TAS2R1&action=edit&section=12" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKinnamon2000" class="citation journal cs1">Kinnamon SC (March 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2981054-5">"A plethora of taste receptors"</a>. <i>Neuron</i>. <b>25</b> (3): <span class="nowrap">507–</span>510. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2981054-5">10.1016/S0896-6273(00)81054-5</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10774719">10774719</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=A+plethora+of+taste+receptors&rft.volume=25&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E507-%3C%2Fspan%3E510&rft.date=2000-03&rft_id=info%3Adoi%2F10.1016%2FS0896-6273%2800%2981054-5&rft_id=info%3Apmid%2F10774719&rft.aulast=Kinnamon&rft.aufirst=SC&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0896-6273%252800%252981054-5&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMargolskee2002" class="citation journal cs1">Margolskee RF (January 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.R100054200">"Molecular mechanisms of bitter and sweet taste transduction"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (1): <span class="nowrap">1–</span>4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.R100054200">10.1074/jbc.R100054200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11696554">11696554</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Molecular+mechanisms+of+bitter+and+sweet+taste+transduction&rft.volume=277&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1-%3C%2Fspan%3E4&rft.date=2002-01&rft_id=info%3Adoi%2F10.1074%2Fjbc.R100054200&rft_id=info%3Apmid%2F11696554&rft.aulast=Margolskee&rft.aufirst=RF&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.R100054200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMontmayeurMatsunami2002" class="citation journal cs1">Montmayeur JP, Matsunami H (August 2002). "Receptors for bitter and sweet taste". <i>Current Opinion in Neurobiology</i>. <b>12</b> (4): <span class="nowrap">366–</span>371. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0959-4388%2802%2900345-8">10.1016/S0959-4388(02)00345-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12139982">12139982</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:37807140">37807140</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Neurobiology&rft.atitle=Receptors+for+bitter+and+sweet+taste&rft.volume=12&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E366-%3C%2Fspan%3E371&rft.date=2002-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A37807140%23id-name%3DS2CID&rft_id=info%3Apmid%2F12139982&rft_id=info%3Adoi%2F10.1016%2FS0959-4388%2802%2900345-8&rft.aulast=Montmayeur&rft.aufirst=JP&rft.au=Matsunami%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFChandrashekarMuellerHoonAdler2000" class="citation journal cs1">Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, et al. (March 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980706-0">"T2Rs function as bitter taste receptors"</a>. <i>Cell</i>. <b>100</b> (6): <span class="nowrap">703–</span>711. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980706-0">10.1016/S0092-8674(00)80706-0</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10761935">10761935</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7293493">7293493</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=T2Rs+function+as+bitter+taste+receptors&rft.volume=100&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E703-%3C%2Fspan%3E711&rft.date=2000-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7293493%23id-name%3DS2CID&rft_id=info%3Apmid%2F10761935&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2800%2980706-0&rft.aulast=Chandrashekar&rft.aufirst=J&rft.au=Mueller%2C+KL&rft.au=Hoon%2C+MA&rft.au=Adler%2C+E&rft.au=Feng%2C+L&rft.au=Guo%2C+W&rft.au=Zuker%2C+CS&rft.au=Ryba%2C+NJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252800%252980706-0&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFFirestein2000" class="citation journal cs1">Firestein S (April 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35007167">"The good taste of genomics"</a>. <i>Nature</i>. <b>404</b> (6778): <span class="nowrap">552–</span>553. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35007167">10.1038/35007167</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10766221">10766221</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:35741332">35741332</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=The+good+taste+of+genomics&rft.volume=404&rft.issue=6778&rft.pages=%3Cspan+class%3D%22nowrap%22%3E552-%3C%2Fspan%3E553&rft.date=2000-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A35741332%23id-name%3DS2CID&rft_id=info%3Apmid%2F10766221&rft_id=info%3Adoi%2F10.1038%2F35007167&rft.aulast=Firestein&rft.aufirst=S&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252F35007167&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZhangHoonChandrashekarMueller2003" class="citation journal cs1">Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, et al. (February 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2803%2900071-0">"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways"</a>. <i>Cell</i>. <b>112</b> (3): <span class="nowrap">293–</span>301. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2803%2900071-0">10.1016/S0092-8674(03)00071-0</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12581520">12581520</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:718601">718601</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Coding+of+sweet%2C+bitter%2C+and+umami+tastes%3A+different+receptor+cells+sharing+similar+signaling+pathways&rft.volume=112&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E293-%3C%2Fspan%3E301&rft.date=2003-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A718601%23id-name%3DS2CID&rft_id=info%3Apmid%2F12581520&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2803%2900071-0&rft.aulast=Zhang&rft.aufirst=Y&rft.au=Hoon%2C+MA&rft.au=Chandrashekar%2C+J&rft.au=Mueller%2C+KL&rft.au=Cook%2C+B&rft.au=Wu%2C+D&rft.au=Zuker%2C+CS&rft.au=Ryba%2C+NJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252803%252900071-0&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFFischerGiladManPääbo2005" class="citation journal cs1">Fischer A, Gilad Y, Man O, Pääbo S (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fmolbev%2Fmsi027">"Evolution of bitter taste receptors in humans and apes"</a>. <i>Molecular Biology and Evolution</i>. <b>22</b> (3): <span class="nowrap">432–</span>436. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fmolbev%2Fmsi027">10.1093/molbev/msi027</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15496549">15496549</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Biology+and+Evolution&rft.atitle=Evolution+of+bitter+taste+receptors+in+humans+and+apes&rft.volume=22&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E432-%3C%2Fspan%3E436&rft.date=2005-03&rft_id=info%3Adoi%2F10.1093%2Fmolbev%2Fmsi027&rft_id=info%3Apmid%2F15496549&rft.aulast=Fischer&rft.aufirst=A&rft.au=Gilad%2C+Y&rft.au=Man%2C+O&rft.au=P%C3%A4%C3%A4bo%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fmolbev%252Fmsi027&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGoSattaTakenakaTakahata2005" class="citation journal cs1">Go Y, Satta Y, Takenaka O, Takahata N (May 2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449719">"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates"</a>. <i>Genetics</i>. <b>170</b> (1): <span class="nowrap">313–</span>326. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1534%2Fgenetics.104.037523">10.1534/genetics.104.037523</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449719">1449719</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15744053">15744053</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Lineage-specific+loss+of+function+of+bitter+taste+receptor+genes+in+humans+and+nonhuman+primates&rft.volume=170&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E313-%3C%2Fspan%3E326&rft.date=2005-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1449719%23id-name%3DPMC&rft_id=info%3Apmid%2F15744053&rft_id=info%3Adoi%2F10.1534%2Fgenetics.104.037523&rft.aulast=Go&rft.aufirst=Y&rft.au=Satta%2C+Y&rft.au=Takenaka%2C+O&rft.au=Takahata%2C+N&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1449719&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATAS2R1" class="Z3988"></span></li></ul> </div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:G_protein-coupled_receptors" title="Template:G protein-coupled receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:G_protein-coupled_receptors" title="Template talk:G protein-coupled receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:G_protein-coupled_receptors" title="Special:EditPage/Template:G protein-coupled receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_surface_receptor:_G_protein-coupled_receptors58" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptor</a>: <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_A:_Rhodopsin-like58" style="font-size:114%;margin:0 4em"><a href="/wiki/Rhodopsin-like_receptors" title="Rhodopsin-like receptors">Class A</a>: <a href="/wiki/Rhodopsin" title="Rhodopsin">Rhodopsin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Neurotransmitter_receptor" title="Neurotransmitter receptor">Neurotransmitter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Adrenergic_receptor" title="Adrenergic receptor">Adrenergic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α1</a> (<a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-1D_adrenergic_receptor" title="Alpha-1D adrenergic receptor">D</a>)</li> <li><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α2</a> (<a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">C</a>)</li> <li><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β1</a></li> <li><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β2</a></li> <li><a href="/wiki/Beta-3_adrenergic_receptor" title="Beta-3 adrenergic receptor">β3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Purinergic_receptor" title="Purinergic receptor">Purinergic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenosine_receptor" title="Adenosine receptor">Adenosine</a> (<a href="/wiki/Adenosine_A1_receptor" title="Adenosine A1 receptor">A1</a></li> <li><a href="/wiki/Adenosine_A2A_receptor" title="Adenosine A2A receptor">A2A</a></li> <li><a href="/wiki/Adenosine_A2B_receptor" title="Adenosine A2B receptor">A2B</a></li> <li><a href="/wiki/Adenosine_A3_receptor" title="Adenosine A3 receptor">A3</a>)</li> <li><a href="/wiki/P2Y_receptor" title="P2Y receptor">P2Y</a> (<a href="/wiki/P2RY1" title="P2RY1">1</a></li> <li><a href="/wiki/P2RY2" title="P2RY2">2</a></li> <li><a href="/wiki/P2RY4" title="P2RY4">4</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">5</a></li> <li><a href="/wiki/P2RY6" title="P2RY6">6</a></li> <li><a href="/wiki/P2RY8" title="P2RY8">8</a></li> <li><a href="/wiki/GPR23" class="mw-redirect" title="GPR23">9</a></li> <li><a href="/wiki/P2RY10" title="P2RY10">10</a></li> <li><a href="/wiki/P2RY11" title="P2RY11">11</a></li> <li><a href="/wiki/P2Y12" title="P2Y12">12</a></li> <li><a href="/wiki/P2RY13" title="P2RY13">13</a></li> <li><a href="/wiki/P2RY14" title="P2RY14">14</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/5-HT_receptor" title="5-HT receptor">Serotonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>(all but <a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3</a>)</i> <a href="/wiki/5-HT1_receptor" title="5-HT1 receptor">5-HT1</a> (<a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">A</a></li> <li><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">B</a></li> <li><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">D</a></li> <li><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">E</a></li> <li><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">F</a>)</li> <li><a href="/wiki/5-HT2_receptor" title="5-HT2 receptor">5-HT2</a> (<a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">A</a></li> <li><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">B</a></li> <li><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">C</a>)</li> <li><i>5-HT</i> (<a href="/wiki/5-HT4_receptor" title="5-HT4 receptor">4</a></li> <li><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5A</a></li> <li><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">6</a></li> <li><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">7</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Muscarinic_acetylcholine_receptor" title="Muscarinic acetylcholine receptor">Acetylcholine</a> (<a href="/wiki/Muscarinic_acetylcholine_receptor_M1" title="Muscarinic acetylcholine receptor M1">M1</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M2" title="Muscarinic acetylcholine receptor M2">M2</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M4" title="Muscarinic acetylcholine receptor M4">M4</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M5" title="Muscarinic acetylcholine receptor M5">M5</a>)</li> <li><a href="/wiki/Dopamine_receptor" title="Dopamine receptor">Dopamine</a> <ul><li><a href="/wiki/Dopamine_receptor_D1" title="Dopamine receptor D1">D1</a></li> <li><a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2</a></li> <li><a href="/wiki/Dopamine_receptor_D3" title="Dopamine receptor D3">D3</a></li> <li><a href="/wiki/Dopamine_receptor_D4" title="Dopamine receptor D4">D4</a></li> <li><a href="/wiki/Dopamine_receptor_D5" title="Dopamine receptor D5">D5</a></li></ul></li> <li><a href="/wiki/GHB_receptor" title="GHB receptor">GHB receptor</a></li> <li><a href="/wiki/Histamine_receptor" title="Histamine receptor">Histamine</a> <ul><li><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a></li> <li><a href="/wiki/Histamine_H2_receptor" title="Histamine H2 receptor">H2</a></li> <li><a href="/wiki/Histamine_H3_receptor" title="Histamine H3 receptor">H3</a></li> <li><a href="/wiki/Histamine_H4_receptor" title="Histamine H4 receptor">H4</a></li></ul></li> <li><a href="/wiki/Melatonin_receptor" title="Melatonin receptor">Melatonin</a> (<a href="/wiki/Melatonin_receptor_1A" title="Melatonin receptor 1A">1A</a></li> <li><a href="/wiki/Melatonin_receptor_1B" title="Melatonin receptor 1B">1B</a></li> <li><a href="/wiki/Melatonin_receptor_1C" title="Melatonin receptor 1C">1C</a>)</li> <li><a href="/wiki/Trace_amine-associated_receptor" title="Trace amine-associated receptor">TAAR</a> (<a href="/wiki/TAAR1" title="TAAR1">1</a></li> <li><a href="/wiki/TAAR2" title="TAAR2">2</a></li> <li><a href="/wiki/TAAR5" title="TAAR5">5</a></li> <li><a href="/wiki/TAAR6" title="TAAR6">6</a></li> <li><a href="/wiki/TAAR8" title="TAAR8">8</a></li> <li><a href="/wiki/TAAR9" title="TAAR9">9</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Metabolites and<br />signaling molecules</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Eicosanoid_receptor" title="Eicosanoid receptor">Eicosanoid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>CysLT</i> (<a href="/wiki/Cysteinyl_leukotriene_receptor_1" title="Cysteinyl leukotriene receptor 1">1</a></li> <li><a href="/wiki/Cysteinyl_leukotriene_receptor_2" title="Cysteinyl leukotriene receptor 2">2</a>)</li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB4</a> <ul><li><a href="/wiki/Leukotriene_B4_receptor" title="Leukotriene B4 receptor">1</a></li> <li><a href="/wiki/Leukotriene_B4_receptor_2" title="Leukotriene B4 receptor 2">2</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2"> FPRL1</a></li> <li><a href="/wiki/Oxoeicosanoid_receptor_1" title="Oxoeicosanoid receptor 1">OXE</a></li> <li><a href="/wiki/Prostaglandin_receptor" title="Prostaglandin receptor">Prostaglandin</a> <ul><li><i>DP</i> (<a href="/wiki/Prostaglandin_D2_receptor" title="Prostaglandin D2 receptor">1</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">2</a>), <i>EP</i> (<a href="/wiki/EP1_receptor" class="mw-redirect" title="EP1 receptor">1</a></li> <li><a href="/wiki/Prostaglandin_E2_receptor" title="Prostaglandin E2 receptor">2</a></li> <li><a href="/wiki/Prostaglandin_E_receptor_3" class="mw-redirect" title="Prostaglandin E receptor 3">3</a></li> <li><a href="/wiki/EP4_receptor" class="mw-redirect" title="EP4 receptor">4</a>), <a href="/wiki/Prostaglandin_F_receptor" title="Prostaglandin F receptor">FP</a></li></ul></li> <li><a href="/wiki/Prostacyclin_receptor" title="Prostacyclin receptor">Prostacyclin</a></li> <li><a href="/wiki/Thromboxane_receptor" title="Thromboxane receptor">Thromboxane</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/G_protein-coupled_bile_acid_receptor" title="G protein-coupled bile acid receptor">Bile acid</a></li> <li><a href="/wiki/Cannabinoid_receptor" title="Cannabinoid receptor">Cannabinoid</a> (<a href="/wiki/Cannabinoid_receptor_type_1" class="mw-redirect" title="Cannabinoid receptor type 1">CB1</a></li> <li><a href="/wiki/Cannabinoid_receptor_type_2" class="mw-redirect" title="Cannabinoid receptor type 2">CB2</a>, <i>GPR</i> (<a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a>))</li> <li><a href="/wiki/GPR183" title="GPR183">EBI2</a></li> <li><a href="/wiki/GPER" title="GPER">Estrogen</a></li> <li><a href="/wiki/Free_fatty_acid_receptor" title="Free fatty acid receptor">Free fatty acid</a> (<a href="/wiki/Free_fatty_acid_receptor_1" title="Free fatty acid receptor 1">1</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_2" title="Free fatty acid receptor 2">2</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_3" title="Free fatty acid receptor 3">3</a></li> <li><a href="/wiki/GPR42" title="GPR42">4</a>)</li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor" title="Hydroxycarboxylic acid receptor">Hydroxycarboxylic acids</a> <ul><li><a href="/wiki/Hydroxycarboxylic_acid_receptor_1" title="Hydroxycarboxylic acid receptor 1">1</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_2" title="Hydroxycarboxylic acid receptor 2">2</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_3" title="Hydroxycarboxylic acid receptor 3">3</a></li></ul></li> <li><a href="/wiki/Lysophosphatidic_acid" title="Lysophosphatidic acid">Lysophosphatidic acid</a> (<a href="/wiki/LPAR1" title="LPAR1">1</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">2</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">3</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">4</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">5</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">6</a>)</li> <li><a href="/wiki/Lysophospholipid_receptor" title="Lysophospholipid receptor">Lysophospholipid</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/LPAR1" title="LPAR1">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">4</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">5</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">6</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">7</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">8</a>)</li> <li><a href="/wiki/OXGR1" title="OXGR1">Oxoglutarate</a></li> <li><a href="/wiki/Platelet-activating_factor_receptor" title="Platelet-activating factor receptor">PAF</a></li> <li><a href="/wiki/Sphingosine-1-phosphate" title="Sphingosine-1-phosphate">Sphingosine-1-phosphate</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">4</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">5</a>)</li> <li><a href="/wiki/SUCNR1" title="SUCNR1">Succinate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Peptide</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/GPCR_neuropeptide_receptor" title="GPCR neuropeptide receptor">Neuropeptide</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neuropeptide_B/W_receptor" title="Neuropeptide B/W receptor">B/W</a> (<a href="/wiki/Neuropeptides_B/W_receptor_1" title="Neuropeptides B/W receptor 1">1</a></li> <li><a href="/wiki/Neuropeptides_B/W_receptor_2" title="Neuropeptides B/W receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_FF_receptor" title="Neuropeptide FF receptor">FF</a> (<a href="/wiki/Neuropeptide_FF_receptor_1" title="Neuropeptide FF receptor 1">1</a></li> <li><a href="/wiki/Neuropeptide_FF_receptor_2" title="Neuropeptide FF receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_S_receptor" title="Neuropeptide S receptor">S</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor" title="Neuropeptide Y receptor">Y</a> (<a href="/wiki/Neuropeptide_Y_receptor_Y1" title="Neuropeptide Y receptor Y1">1</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y2" title="Neuropeptide Y receptor Y2">2</a></li> <li><a href="/wiki/Pancreatic_polypeptide_receptor_1" title="Pancreatic polypeptide receptor 1">4</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y5" title="Neuropeptide Y receptor Y5">5</a>)</li> <li><i>Neuromedin</i> (<a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">B</a></li> <li><a href="/wiki/Neuromedin_U_receptor" title="Neuromedin U receptor">U</a> (<a href="/wiki/Neuromedin_U_receptor_1" title="Neuromedin U receptor 1">1</a></li> <li><a href="/wiki/Neuromedin_U_receptor_2" title="Neuromedin U receptor 2">2</a>))</li> <li><a href="/wiki/Neurotensin_receptor" title="Neurotensin receptor">Neurotensin</a> (<a href="/wiki/Neurotensin_receptor_1" title="Neurotensin receptor 1">1</a></li> <li><a href="/wiki/Neurotensin_receptor_2" title="Neurotensin receptor 2">2</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anaphylatoxin_receptors" title="Anaphylatoxin receptors">Anaphylatoxin</a> (<a href="/wiki/C3a_receptor" title="C3a receptor">C3a</a></li> <li>C5a (<a href="/wiki/C5a_receptor" title="C5a receptor">1</a></li> <li><a href="/wiki/C5AR2" title="C5AR2">2</a>))</li> <li><a href="/wiki/Angiotensin_receptor" class="mw-redirect" title="Angiotensin receptor">Angiotensin</a> (<a href="/wiki/Angiotensin_II_receptor_type_1" title="Angiotensin II receptor type 1">1</a></li> <li><a href="/wiki/Angiotensin_II_receptor_type_2" title="Angiotensin II receptor type 2">2</a>)</li> <li><a href="/wiki/Apelin_receptor" title="Apelin receptor">Apelin</a></li> <li><a href="/wiki/Bombesin_receptor" title="Bombesin receptor">Bombesin</a> <ul><li><a href="/wiki/Bombesin-like_receptor_3" title="Bombesin-like receptor 3">BRS3</a></li> <li><a href="/wiki/Gastrin-releasing_peptide_receptor" title="Gastrin-releasing peptide receptor">GRPR</a></li> <li><a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">NMBR</a>)</li> <li><a href="/wiki/Bradykinin_receptor" title="Bradykinin receptor">Bradykinin</a> (<a href="/wiki/Bradykinin_receptor_B1" title="Bradykinin receptor B1">B1</a></li> <li><a href="/wiki/Bradykinin_receptor_B2" title="Bradykinin receptor B2">B2</a>)</li></ul></li> <li><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></li> <li><a href="/wiki/Cholecystokinin_receptor" title="Cholecystokinin receptor">Cholecystokinin</a> (<a href="/wiki/Cholecystokinin_A_receptor" title="Cholecystokinin A receptor">A</a></li> <li><a href="/wiki/Cholecystokinin_B_receptor" title="Cholecystokinin B receptor">B</a>)</li> <li><a href="/wiki/Endothelin_receptor" title="Endothelin receptor">Endothelin</a> <ul><li><a href="/wiki/Endothelin_A_receptor" title="Endothelin A receptor">A</a></li> <li><a href="/wiki/Endothelin_B_receptor" class="mw-redirect" title="Endothelin B receptor">B</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor" title="Formyl peptide receptor">Formyl peptide</a> (<a href="/wiki/Formyl_peptide_receptor_1" title="Formyl peptide receptor 1">1</a></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2">2</a></li> <li><a href="/wiki/Formyl_peptide_receptor_3" title="Formyl peptide receptor 3">3</a>)</li> <li><a href="/wiki/Follicle-stimulating_hormone_receptor" title="Follicle-stimulating hormone receptor">FSH</a></li> <li><a href="/wiki/Galanin_receptor" title="Galanin receptor">Galanin</a> (<a href="/wiki/Galanin_receptor_1" title="Galanin receptor 1">1</a></li> <li><a href="/wiki/Galanin_receptor_2" title="Galanin receptor 2">2</a></li> <li><a href="/wiki/Galanin_receptor_3" title="Galanin receptor 3">3</a>)</li> <li><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor">Gonadotropin-releasing hormone</a> (<a href="/wiki/GNRHR" title="GNRHR">1</a></li> <li><a href="/wiki/GNRHR2" title="GNRHR2">2</a>)</li> <li><a href="/wiki/Growth_hormone_secretagogue_receptor" title="Growth hormone secretagogue receptor">Ghrelin</a></li> <li><a href="/wiki/KiSS1-derived_peptide_receptor" title="KiSS1-derived peptide receptor"> Kisspeptin</a></li> <li><a href="/wiki/Luteinizing_hormone/choriogonadotropin_receptor" title="Luteinizing hormone/choriogonadotropin receptor">Luteinizing hormone/choriogonadotropin</a></li> <li><a href="/wiki/MAS1_oncogene" title="MAS1 oncogene">MAS</a> (<a href="/wiki/MAS1" title="MAS1">1</a></li> <li><a href="/wiki/MAS1L" title="MAS1L">1L</a></li> <li><a href="/wiki/MRGPRD" title="MRGPRD">D</a></li> <li><a href="/wiki/MRGPRE" title="MRGPRE">E</a></li> <li><a href="/wiki/MRGPRF" title="MRGPRF">F</a></li> <li><a href="/wiki/MRGPRG" title="MRGPRG">G</a></li> <li><a href="/wiki/MRGPRX1" title="MRGPRX1">X1</a></li> <li><a href="/wiki/MRGPRX2" title="MRGPRX2">X2</a></li> <li><a href="/wiki/MRGPRX3" title="MRGPRX3">X3</a></li> <li><a href="/wiki/MRGPRX4" title="MRGPRX4">X4</a>)</li> <li><a href="/wiki/Melanocortin_receptor" title="Melanocortin receptor">Melanocortin</a> (<a href="/wiki/Melanocortin_1_receptor" title="Melanocortin 1 receptor">1</a></li> <li><a href="/wiki/ACTH_receptor" title="ACTH receptor">2</a></li> <li><a href="/wiki/Melanocortin_3_receptor" title="Melanocortin 3 receptor">3</a></li> <li><a href="/wiki/Melanocortin_4_receptor" title="Melanocortin 4 receptor">4</a></li> <li><a href="/wiki/Melanocortin_5_receptor" title="Melanocortin 5 receptor">5</a>)</li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor" title="Melanin-concentrating hormone receptor">MCHR</a> (<a href="/wiki/Melanin-concentrating_hormone_receptor_1" title="Melanin-concentrating hormone receptor 1">1</a></li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor_2" title="Melanin-concentrating hormone receptor 2">2</a>)</li> <li><a href="/wiki/Motilin_receptor" title="Motilin receptor">Motilin</a></li> <li><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid</a> (<a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">Delta</a></li> <li><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">Kappa</a></li> <li><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">Mu</a></li> <li><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a> & <a href="/wiki/OGFr" title="OGFr">Zeta</a>, but not <a href="/wiki/Sigma_receptor" title="Sigma receptor">Sigma</a>)</li> <li><a href="/wiki/Orexin_receptor" title="Orexin receptor">Orexin</a> (<a href="/wiki/Hypocretin_(orexin)_receptor_1" title="Hypocretin (orexin) receptor 1">1</a></li> <li><a href="/wiki/Hypocretin_(orexin)_receptor_2" title="Hypocretin (orexin) receptor 2">2</a>)</li> <li><a href="/wiki/Oxytocin_receptor" title="Oxytocin receptor">Oxytocin</a></li> <li><a href="/wiki/Prokineticin_receptor" title="Prokineticin receptor">Prokineticin</a> (<a href="/wiki/Prokineticin_receptor_1" title="Prokineticin receptor 1">1</a></li> <li><a href="/wiki/Prokineticin_receptor_2" title="Prokineticin receptor 2">2</a>)</li> <li><a href="/wiki/Prolactin-releasing_peptide_receptor" title="Prolactin-releasing peptide receptor">Prolactin-releasing peptide</a></li> <li><a href="/wiki/Relaxin_receptor" title="Relaxin receptor">Relaxin</a> (<a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_1" title="Relaxin/insulin-like family peptide receptor 1">1</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_2" title="Relaxin/insulin-like family peptide receptor 2">2</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_3" title="Relaxin/insulin-like family peptide receptor 3">3</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_4" title="Relaxin/insulin-like family peptide receptor 4">4</a>)</li> <li><a href="/wiki/Somatostatin_receptor" title="Somatostatin receptor">Somatostatin</a> (<a href="/wiki/Somatostatin_receptor_1" title="Somatostatin receptor 1">1</a></li> <li><a href="/wiki/Somatostatin_receptor_2" title="Somatostatin receptor 2">2</a></li> <li><a href="/wiki/Somatostatin_receptor_3" title="Somatostatin receptor 3">3</a></li> <li><a href="/wiki/Somatostatin_receptor_4" title="Somatostatin receptor 4">4</a></li> <li><a href="/wiki/Somatostatin_receptor_5" title="Somatostatin receptor 5">5</a>)</li> <li><a href="/wiki/Tachykinin_receptor" title="Tachykinin receptor">Tachykinin</a> (<a href="/wiki/Tachykinin_receptor_1" title="Tachykinin receptor 1">1</a></li> <li><a href="/wiki/Tachykinin_receptor_2" title="Tachykinin receptor 2">2</a></li> <li><a href="/wiki/Tachykinin_receptor_3" title="Tachykinin receptor 3">3</a>)</li> <li><a href="/wiki/Thyrotropin_receptor" title="Thyrotropin receptor">Thyrotropin</a></li> <li><a href="/wiki/Thyrotropin-releasing_hormone_receptor" title="Thyrotropin-releasing hormone receptor">Thyrotropin-releasing hormone</a></li> <li><a href="/wiki/Urotensin-II_receptor" title="Urotensin-II receptor">Urotensin-II</a></li> <li><a href="/wiki/Vasopressin_receptor" title="Vasopressin receptor">Vasopressin</a> (<a href="/wiki/Arginine_vasopressin_receptor_1A" class="mw-redirect" title="Arginine vasopressin receptor 1A">1A</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_1B" class="mw-redirect" title="Arginine vasopressin receptor 1B">1B</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_2" class="mw-redirect" title="Arginine vasopressin receptor 2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, bitter</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS2R</i> <ul><li><a class="mw-selflink selflink">1</a></li> <li><a href="/wiki/TAS2R3" title="TAS2R3">3</a></li> <li><a href="/wiki/TAS2R4" title="TAS2R4">4</a></li> <li><a href="/wiki/TAS2R5" title="TAS2R5">5</a></li> <li><a href="/wiki/TAS2R7" title="TAS2R7">7</a></li> <li><a href="/wiki/TAS2R8" title="TAS2R8">8</a></li> <li><a href="/wiki/TAS2R9" title="TAS2R9">9</a></li> <li><a href="/wiki/TAS2R10" title="TAS2R10">10</a></li> <li><a href="/wiki/TAS2R13" title="TAS2R13">13</a></li> <li><a href="/wiki/TAS2R14" title="TAS2R14">14</a></li> <li><a href="/wiki/TAS2R16" title="TAS2R16">16</a></li> <li><a href="/wiki/TAS2R19" title="TAS2R19">19</a></li> <li><a href="/wiki/TAS2R20" title="TAS2R20">20</a></li> <li><a href="/wiki/TAS2R30" title="TAS2R30">30</a></li> <li><a href="/wiki/TAS2R31" title="TAS2R31">31</a></li> <li><a href="/wiki/TAS2R38" title="TAS2R38">38</a></li> <li><a href="/wiki/TAS2R39" title="TAS2R39">39</a></li> <li><a href="/wiki/TAS2R40" title="TAS2R40">40</a></li> <li><a href="/wiki/TAS2R41" title="TAS2R41">41</a></li> <li><a href="/wiki/TAS2R42" title="TAS2R42">42</a></li> <li><a href="/wiki/TAS2R43" title="TAS2R43">43</a></li> <li><a href="/wiki/TAS2R45" title="TAS2R45">45</a></li> <li><a href="/wiki/TAS2R46" title="TAS2R46">46</a></li> <li><a href="/wiki/TAS2R50" title="TAS2R50">50</a></li> <li><a href="/wiki/TAS2R60" title="TAS2R60">60</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a> type 1</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR1" title="GPR1">1</a></li> <li><a href="/wiki/GPR3" title="GPR3">3</a></li> <li><a href="/wiki/GPR4" title="GPR4">4</a></li> <li><a href="/wiki/GPR6" title="GPR6">6</a></li> <li><a href="/wiki/GPR12" title="GPR12">12</a></li> <li><a href="/wiki/GPR15" title="GPR15">15</a></li> <li><a href="/wiki/GPR17" title="GPR17">17</a></li> <li><a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR19" title="GPR19">19</a></li> <li><a href="/wiki/GPR20" title="GPR20">20</a></li> <li><a href="/wiki/GPR21" title="GPR21">21</a></li> <li><a href="/wiki/GPR22" title="GPR22">22</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">23</a></li> <li><a href="/wiki/GPR25" title="GPR25">25</a></li> <li><a href="/wiki/GPR26" title="GPR26">26</a></li> <li><a href="/wiki/GPR27" title="GPR27">27</a></li> <li><a href="/wiki/GPR31" title="GPR31">31</a></li> <li><a href="/wiki/GPR32" title="GPR32">32</a></li> <li><a href="/wiki/GPR33" title="GPR33">33</a></li> <li><a href="/wiki/GPR34" title="GPR34">34</a></li> <li><a href="/wiki/GPR35" title="GPR35">35</a></li> <li><a href="/wiki/GPR37" title="GPR37">37</a></li> <li><a href="/wiki/GPR39" title="GPR39">39</a></li> <li><a href="/wiki/GPR42" title="GPR42">42</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">44</a></li> <li><a href="/wiki/GPR45" title="GPR45">45</a></li> <li><a href="/wiki/GPR50" title="GPR50">50</a></li> <li><a href="/wiki/GPR52" title="GPR52">52</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR61" title="GPR61">61</a></li> <li><a href="/wiki/GPR62" title="GPR62">62</a></li> <li><a href="/wiki/GPR63" title="GPR63">63</a></li> <li><a href="/wiki/GPR65" title="GPR65">65</a></li> <li><a href="/wiki/GPR68" title="GPR68">68</a></li> <li><a href="/wiki/GPR75" title="GPR75">75</a></li> <li><a href="/wiki/GPR78" title="GPR78">78</a></li> <li><a href="/wiki/GPR81" class="mw-redirect" title="GPR81">81</a></li> <li><a href="/wiki/GPR82" title="GPR82">82</a></li> <li><a href="/wiki/GPR83" title="GPR83">83</a></li> <li><a href="/wiki/GPR84" title="GPR84">84</a></li> <li><a href="/wiki/GPR85" title="GPR85">85</a></li> <li><a href="/wiki/GPR87" title="GPR87">87</a></li> <li><a href="/wiki/GPR88" title="GPR88">88</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">92</a></li> <li><a href="/wiki/GPR101" title="GPR101">101</a></li> <li><a href="/wiki/Pyroglutamylated_RFamide_peptide_receptor" title="Pyroglutamylated RFamide peptide receptor">103</a></li> <li><a href="/wiki/Niacin_receptor_1" class="mw-redirect" title="Niacin receptor 1">109A</a></li> <li><a href="/wiki/Niacin_receptor_2" class="mw-redirect" title="Niacin receptor 2">109B</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a></li> <li><a href="/wiki/GPR120" class="mw-redirect" title="GPR120">120</a></li> <li><a href="/wiki/GPR132" title="GPR132">132</a></li> <li><a href="/wiki/GPR135" title="GPR135">135</a></li> <li><a href="/wiki/GPR137B" title="GPR137B">137B</a></li> <li><a href="/wiki/GPR139" title="GPR139">139</a></li> <li><a href="/wiki/GPR141" title="GPR141">141</a></li> <li><a href="/wiki/GPR142" title="GPR142">142</a></li> <li><a href="/wiki/GPR146" title="GPR146">146</a></li> <li><a href="/wiki/GPR148" title="GPR148">148</a></li> <li><a href="/wiki/GPR149" title="GPR149">149</a></li> <li><a href="/wiki/GPR150" title="GPR150">150</a></li> <li><a href="/wiki/GPR151" title="GPR151">151</a></li> <li><a href="/wiki/GPR152" title="GPR152">152</a></li> <li><a href="/wiki/GPR153" title="GPR153">153</a></li> <li><a href="/wiki/GPR160" title="GPR160">160</a></li> <li><a href="/wiki/GPR161" title="GPR161">161</a></li> <li><a href="/wiki/GPR162" title="GPR162">162</a></li> <li><a href="/wiki/GPR171" title="GPR171">171</a></li> <li><a href="/wiki/GPR173" title="GPR173">173</a></li> <li><a href="/wiki/GPR174" title="GPR174">174</a></li> <li><a href="/wiki/GPR176" title="GPR176">176</a></li> <li><a href="/wiki/GPR177" class="mw-redirect" title="GPR177">177</a></li> <li><a href="/wiki/GPR182" title="GPR182">182</a></li> <li><a href="/wiki/GPR183" title="GPR183">183</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GPR182" title="GPR182">Adrenomedullin</a></li> <li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">Olfactory</a></li> <li><a href="/wiki/Opsin" title="Opsin">Opsin</a> (<a href="/wiki/OPN3" title="OPN3">3</a></li> <li><a href="/wiki/Melanopsin" title="Melanopsin">4</a></li> <li><a href="/wiki/OPN5" title="OPN5">5</a></li> <li><a href="/wiki/OPN1LW" title="OPN1LW">1LW</a></li> <li><a href="/wiki/OPN1MW" title="OPN1MW">1MW</a></li> <li><a href="/wiki/OPN1SW" title="OPN1SW">1SW</a></li> <li><a href="/wiki/Retinal_G_protein_coupled_receptor" title="Retinal G protein coupled receptor">RGR</a></li> <li><a href="/wiki/RRH" title="RRH">RRH</a>)</li> <li><a href="/wiki/Protease-activated_receptor" title="Protease-activated receptor">Protease-activated</a> (<a href="/wiki/Coagulation_factor_II_receptor" class="mw-redirect" title="Coagulation factor II receptor">1</a></li> <li><a href="/wiki/Protease_activated_receptor_2" class="mw-redirect" title="Protease activated receptor 2">2</a></li> <li><a href="/wiki/F2RL2" title="F2RL2">3</a></li> <li><a href="/wiki/F2RL3" title="F2RL3">4</a>)</li> <li><a href="/wiki/Super_Conserved_Receptor_Expressed_in_Brain" title="Super Conserved Receptor Expressed in Brain">SREB</a> (<a href="/wiki/GPR27" title="GPR27">1</a></li> <li><a href="/wiki/GPR85" title="GPR85">2</a></li> <li><a href="/wiki/GPR173" title="GPR173">3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_B:_Secretin-like58" style="font-size:114%;margin:0 4em"><a href="/wiki/Secretin_receptor_family" title="Secretin receptor family">Class B</a>: <a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Adhesion_G_protein-coupled_receptor" title="Adhesion G protein-coupled receptor">Adhesion</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ADGRB</i> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor" title="Brain-specific angiogenesis inhibitor">Brain-specific angiogenesis inhibitor</a> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_1" title="Brain-specific angiogenesis inhibitor 1">1</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_2" title="Brain-specific angiogenesis inhibitor 2">2</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_3" title="Brain-specific angiogenesis inhibitor 3">3</a></li></ul></li></ul></li> <li><i>ADGRC</i> <ul><li><a href="/wiki/Flamingo_(protein)" title="Flamingo (protein)">Cadherin</a> <ul><li><a href="/wiki/CELSR1" title="CELSR1">1</a></li> <li><a href="/wiki/CELSR2" title="CELSR2">2</a></li> <li><a href="/wiki/CELSR3" title="CELSR3">3</a></li></ul></li></ul></li> <li><i>ADGRE</i> <ul><li><a href="/wiki/EGF_module-containing_mucin-like_hormone_receptor" title="EGF module-containing mucin-like hormone receptor">EMR</a> <ul><li><a href="/wiki/EMR1" title="EMR1">1</a></li> <li><a href="/wiki/EMR2" title="EMR2">2</a></li> <li><a href="/wiki/EMR3" title="EMR3">3</a></li></ul></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li></ul></li> <li><i>ADGRG</i> <ul><li><a href="/wiki/GPR56" title="GPR56">1</a></li> <li><a href="/wiki/GPR64" title="GPR64">2</a></li> <li><a href="/wiki/GPR97" title="GPR97">3</a></li> <li><a href="/wiki/GPR112" title="GPR112">4</a></li> <li><a href="/wiki/GPR114" title="GPR114">5</a></li> <li><a href="/wiki/GPR126" title="GPR126">6</a></li> <li><a href="/wiki/GPR128" title="GPR128">7</a></li></ul></li> <li><i>ADGRL</i> <ul><li><a href="/wiki/Latrophilin_receptor" class="mw-redirect" title="Latrophilin receptor">Latrophilin</a> <ul><li><a href="/wiki/Latrophilin_1" title="Latrophilin 1">1</a></li> <li><a href="/wiki/Latrophilin_2" title="Latrophilin 2">2</a></li> <li><a href="/wiki/Latrophilin_3" title="Latrophilin 3">3</a></li></ul></li> <li><a href="/wiki/ELTD1" class="mw-redirect" title="ELTD1">ELTD1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR56" title="GPR56">56</a></li> <li><a href="/wiki/GPR64" title="GPR64">64</a></li> <li><a href="/wiki/GPR97" title="GPR97">97</a></li> <li><a href="/wiki/GPR98" title="GPR98">98</a></li> <li><a href="/wiki/GPR110" title="GPR110">110</a></li> <li><a href="/wiki/GPR111" title="GPR111">111</a></li> <li><a href="/wiki/GPR112" title="GPR112">112</a></li> <li><a href="/wiki/GPR113" title="GPR113">113</a></li> <li><a href="/wiki/GPR114" title="GPR114">114</a></li> <li><a href="/wiki/GPR115" title="GPR115">115</a></li> <li><a href="/wiki/GPR116" title="GPR116">116</a></li> <li><a href="/wiki/GPR123" title="GPR123">123</a></li> <li><a href="/wiki/GPR124" title="GPR124">124</a></li> <li><a href="/wiki/GPR125" title="GPR125">125</a></li> <li><a href="/wiki/GPR126" title="GPR126">126</a></li> <li><a href="/wiki/GPR128" title="GPR128">128</a></li> <li><a href="/wiki/GPR133" title="GPR133">133</a></li> <li><a href="/wiki/GPR143" title="GPR143">143</a></li> <li><a href="/wiki/GPR144" title="GPR144">144</a></li> <li><a href="/wiki/GPR155" title="GPR155">155</a></li> <li><a href="/wiki/GPR157" title="GPR157">157</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin_receptor" title="Calcitonin receptor">Calcitonin</a></li> <li><a href="/wiki/CALCRL" title="CALCRL">CALCRL</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor" title="Corticotropin-releasing hormone receptor">Corticotropin-releasing hormone</a> (<a href="/wiki/Corticotropin-releasing_hormone_receptor_1" title="Corticotropin-releasing hormone receptor 1">1</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor_2" title="Corticotropin-releasing hormone receptor 2">2</a>)</li> <li><a href="/wiki/Glucagon_receptor_family" title="Glucagon receptor family">Glucagon</a> (<a href="/wiki/Glucagon_receptor" title="Glucagon receptor">GR</a></li> <li><a href="/wiki/Gastric_inhibitory_polypeptide_receptor" title="Gastric inhibitory polypeptide receptor">GIPR</a></li> <li><a href="/wiki/Glucagon-like_peptide-1_receptor" title="Glucagon-like peptide-1 receptor">GLP1R</a></li> <li><a href="/wiki/Glucagon-like_peptide-2_receptor" title="Glucagon-like peptide-2 receptor">GLP2R</a>)</li> <li><a href="/wiki/Growth-hormone-releasing_hormone_receptor" title="Growth-hormone-releasing hormone receptor">Growth-hormone-releasing hormone</a></li> <li><a href="/wiki/ADCYAP1R1" title="ADCYAP1R1">PACAPR1</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a></li> <li><a href="/wiki/Methuselah-like_proteins" title="Methuselah-like proteins">Methuselah-like proteins</a></li> <li><a href="/wiki/Parathyroid_hormone_receptor" title="Parathyroid hormone receptor">Parathyroid hormone</a> (<a href="/wiki/Parathyroid_hormone_1_receptor" title="Parathyroid hormone 1 receptor">1</a></li> <li><a href="/wiki/Parathyroid_hormone_2_receptor" title="Parathyroid hormone 2 receptor">2</a>)</li> <li><a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a></li> <li><a href="/wiki/Vasoactive_intestinal_peptide_receptor" title="Vasoactive intestinal peptide receptor">Vasoactive intestinal peptide</a> (<a href="/wiki/VIPR1" title="VIPR1">1</a></li> <li><a href="/wiki/VIPR2" title="VIPR2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_C:_Metabotropic_glutamate_/_pheromone58" style="font-size:114%;margin:0 4em"><a href="/wiki/Class_C_GPCR" title="Class C GPCR">Class C</a>: <a href="/wiki/Metabotropic_receptor" title="Metabotropic receptor">Metabotropic</a> <a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">glutamate</a> / <a href="/wiki/Pheromone" title="Pheromone">pheromone</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, sweet</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS1R</i> <ul><li><a href="/wiki/TAS1R1" title="TAS1R1">1</a></li> <li><a href="/wiki/TAS1R2" title="TAS1R2">2</a></li> <li><a href="/wiki/TAS1R3" title="TAS1R3">3</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a>, type 2</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">Calcium-sensing receptor</a></li> <li><a href="/wiki/GABA_receptor" title="GABA receptor">GABA<sub>B</sub></a> (<a href="/wiki/GABBR1" title="GABBR1">1</a></li> <li><a href="/wiki/GABBR2" title="GABBR2">2</a>)</li> <li><a href="/wiki/Glutamate_receptor" title="Glutamate receptor">Glutamate receptor</a> (<a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">Metabotropic glutamate</a> (<a href="/wiki/Metabotropic_glutamate_receptor_1" title="Metabotropic glutamate receptor 1">1</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_2" title="Metabotropic glutamate receptor 2">2</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_3" title="Metabotropic glutamate receptor 3">3</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_4" title="Metabotropic glutamate receptor 4">4</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_5" title="Metabotropic glutamate receptor 5">5</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_6" title="Metabotropic glutamate receptor 6">6</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_7" title="Metabotropic glutamate receptor 7">7</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_8" title="Metabotropic glutamate receptor 8">8</a>))</li> <li><a href="/wiki/GPRC6A" title="GPRC6A">GPRC6A</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a> (<a href="/wiki/GPR156" title="GPR156">156</a></li> <li><a href="/wiki/GPR158" title="GPR158">158</a></li> <li><a href="/wiki/GPR179" title="GPR179">179</a>)</li> <li><a href="/wiki/Retinoic_acid-inducible_orphan_G_protein-coupled_receptor" title="Retinoic acid-inducible orphan G protein-coupled receptor">RAIG</a> (<a href="/wiki/GPRC5A" title="GPRC5A">1</a></li> <li><a href="/wiki/GPRC5B" title="GPRC5B">2</a></li> <li><a href="/wiki/GPRC5C" title="GPRC5C">3</a></li> <li><a href="/wiki/GPRC5D" title="GPRC5D">4</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_F:_Frizzled_&amp;_Smoothened58" style="font-size:114%;margin:0 4em">Class F: <a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> & <a href="/wiki/Smoothened" title="Smoothened">Smoothened</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;">Frizzled</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> (<a href="/wiki/FZD1" class="mw-redirect" title="FZD1">1</a></li> <li><a href="/wiki/FZD2" class="mw-redirect" title="FZD2">2</a></li> <li><a href="/wiki/FZD3" class="mw-redirect" title="FZD3">3</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">4</a></li> <li><a href="/wiki/FZD5" class="mw-redirect" title="FZD5">5</a></li> <li><a href="/wiki/FZD6" class="mw-redirect" title="FZD6">6</a></li> <li><a href="/wiki/FZD7" class="mw-redirect" title="FZD7">7</a></li> <li><a href="/wiki/FZD8" class="mw-redirect" title="FZD8">8</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">9</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">10</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;">Smoothened</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Smoothened" title="Smoothened">Smoothened</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public 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