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nav-link">Library</a> </li> </ul> </li> </ul> </div> </nav> </div> </div> </div> <div id="page" class="page-max-width"> <main class="main" id="main"> <div class="hero-field landing-page-hero"> <style scoped> .hero-image { background-image: url(/sites/default/files/hero-images/about-alk-hero.jpg); } @media (max-width: 767.98px) { .hero-image { background-image: url(/sites/default/files/2022-03/about-alk-hero-mobile.jpg); } } </style> <div class="hero-image"> <div class="hero-label hero-label-"> <div> <div class="hero-label-txt"> <p class="hero-label-eyebrow">ALK</p><h1>About <strong>ALK-positive</strong><br>Lung Cancer</h1> </div> </div> </div> <img class="hero-image-curve" src="/themes/custom/lungevity/images/hero-curve.svg" aria-hidden="true" /> </div> </div> <div class="content-wrapper"> <div id="content" role="main"> <a id="main-content"></a> <div class="container-fluid"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="43" class="node node--type-content-page node--view-mode-full"> <div class="node__content"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-layout-builder block-extra-field-blocknodecontent-pagelinks"> </div> <div class="block block-layout-builder block-field-blocknodecontent-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="row"><div class="col-md-6"><h2><strong>If you have non-small cell lung cancer (NSCLC) and your doctor told you that you have an ALK biomarker, this site will help you understand what your diagnosis means and how it impacts your treatment options. Use this information to help you talk with your doctor to decide the best treatment options for you.</strong></h2></div><div class="col-md-6"><div class="bg-primary text-white float-right p-3 ml-md-4 mb-3"><h2 class="font-weight-light text-white mt-0">What is a <strong>biomarker?</strong></h2><p>A biomarker is a substance that doctors can measure in tissues, blood, or other body fluids like spit. In ALK cancer, biomarkers are changes in a cell’s genes (building blocks of a cell’s DNA) or proteins that cause the cancer to grow. These mutations are called “driver mutations” because they cause (or “drive”) cancer to grow.</p></div></div></div><h2><strong>What is ALK?</strong></h2><p>ALK stands for anaplastic lymphoma kinase. ALK is a type of gene that exists in all of us. The ALK gene makes a protein that is involved in cell growth. Changes to the naturally occurring ALK gene can cause cancer.</p><div class="row"><div class="col-md-6"><h2><strong>What causes ALK-positive NSCLC?</strong></h2><p>What causes ALK-positive NSCLC? ALK-positive NSCLC is caused by a gene fusion (joining of two genes together), also called a rearrangement, of two genes: ALK and, most commonly, echinoderm microtubule-associated protein-like 4 (EML4).</p><p>The fusion of these two genes produces an abnormal (changed) ALK protein that causes cancer cells to grow and spread.</p><p>While the ALK gene is naturally occurring, the gene fusion that causes ALK-positive NSCLC isn’t a hereditary mutation; people with ALK-positive lung cancer are not born with mutated ALK genes and didn’t inherit it from their parents. Their mutation is considered an “acquired mutation,” which means the fusion occurred due to a variety of possible factors, such as exposure to carcinogens.</p><h2><strong>Who gets ALK-positive NSCLC</strong>?</h2><p>People with the ALK fusion tend to be younger than the average person with lung cancer; the median age at diagnosis for people with ALK-positive NSCLC is 52 years. It is also common in nonsmokers or light smokers and those with lung adenocarcinoma. It has rarely been found in patients with squamous cell lung cancer.</p><p>About 5% of people with NSCLC in Western populations have tumors with an ALK fusion.</p></div><div class="col-md-6"><div class="border ml-md-4"><div class="bg-gray text-white p-3"><span class="font-size-24">How targeted therapy works</span></div><div class="p-3 bg-white "><img src="/sites/default/files/inline-images/about-alk-1.png" data-entity-uuid="f3c3f084-5ee2-47d9-aabf-a51f327b78c4" data-entity-type="file" alt="ALK funtion" width="330" height="360" class="align-center" loading="lazy">ALK fusion happens when the ALK gene fuses (joins) with another gene, such as EML4. The fused gene sends signals that lead cells to grow out of control, which means 1 cell divides into many cells and causes cancer.</div></div></div></div><h2>How do I know if I have an ALK mutation?</h2><p>After being diagnosed with lung cancer, ask your doctor for comprehensive biomarker testing. Comprehensive biomarker testing checks your lung cancer for a full list of biomarkers, including ALK, that doctors have linked to NSCLC. It is important to know if you have any biomarkers to help decide what your treatment options might be – different treatments work better on cancers with certain biomarkers.</p><p>There are two types of biomarker testing: tissue biopsy and liquid biopsy. During a tissue biopsy, doctors will use a sharp tool to get a sample of tissue from your lung cancer. During a liquid biopsy, doctors will take a sample of blood to look for cancer cells from your lung cancer tumor circulating in your blood. Currently, tissue biopsies are the standard of care if you have enough tissue, but liquid biopsies are showing potential to be as accurate as tissue biopsies in the future.</p><p>If your biomarker test shows you have ALK-positive NSCLC, your doctor may refer to it as an ALK mutation, ALK biomarker, ALK fusion, ALK rearrangement, or ALK-positive lung cancer.</p><h2>How do doctors treat ALK-positive NSCLC?</h2><p>You will work with your doctor to decide on the treatment that is best for you, based on your stage of ALK-positive NSCLC.</p><p>Currently, ALK-positive NSCLC is most often treated with targeted therapy, which is a type of treatment that finds and attacks certain parts of cancer cells and the signals sent to cancer cells that cause them to grow uncontrolled. They prevent the growth of cancer cells only, and do not harm healthy cells.</p><p>There are different types of targeted therapy, but ALK-positive NSCLC responds best to targeted therapies with tyrosine kinase inhibitors (TKIs). Tyrosine kinases are proteins that allow signals to be sent from one cell to the other. These signals are sent to tyrosine kinase receptors on cells. When you have an ALK mutation, the tyrosine kinases send messages to the receptors that tell the cancer cells to grow and spread. However, when you receive a TKI, the drug blocks the signal from reaching the receptor, which means the cancer cells do not continue to grow and spread and the cancer is kept in check.</p><p>There are currently six FDA-approved ALK TKIs (also called ALK inhibitors):</p><ul><li>Alectinib (Alecensa®): A kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test. It is also approved for adjuvant treatment in adult patients following tumor resection of ALK-positive NSCLC (tumors ≥ 4 cm or node positive) as detected by an FDA-approved test.</li><li>Brigatinib (Alunbrig®): Approved for adult patients with metastatic ALK-positive NSCLC, as detected by an FDA-approved test</li><li>Ceritinib (Zykadia®): Approved for patients with metastatic ALK-positive NSCLC, as detected by an FDA-approved test</li><li>Crizotinib (Xalkori®): Approved for patients with metastatic ALK-positive NSCLC, as detected by an FDA-approved test</li><li>Ensartinib (Ensacove<sup>TM</sup>): Approved for adult patients with ALK-positive locally advanced or metastatic NSCLC who have not previously received an ALK inhibitor</li><li>Lorlatinib (Lorbrena®): Approved for adult patients with metastatic ALK-positive NSCLC, as detected by an FDA-approved test</li></ul><h2>What are some side effects of ALK-positive NSCLC treatments?</h2><p>Side effects of the ALK-positive NSCLC treatments differ by drug and by patient. Some common side effects of ALK TKIs include:</p><ul><li>Nausea</li><li>Vomiting</li><li>Diarrhea</li><li>Constipation</li><li>Fatigue</li><li>Swelling of the hands or feet</li></ul><p>Among the more serious but less common side effects of ALK TKIs are:</p><ul><li>Liver problems</li><li>Pneumonitis</li><li>Abnormal heartbeats</li></ul><p>In addition, crizotinib (Xalkori®) and ensartinib (Ensacove<sup>TM</sup>) have unique vision-specific side effects. These include:</p><ul><li>Trouble looking at light</li><li>Blurred vision</li><li>Double vision</li><li>Seeing flashes of light</li><li>New or increased floaters</li></ul><p>Ensartinib (Ensacove<sup>TM</sup>) can cause dermatologic adverse reactions, including:</p><ul><li>Drug reaction with eosinophilia and systemic symptoms (DRESS)</li><li>Rash</li><li>Itching</li><li>Photosensitivity</li></ul><p>Low testosterone is one source of fatigue in patients being treated with crizotinib (Xalkori®). This can also lead to sexual dysfunction and depression.</p><p><a class="btn btn-secondary mr-3" href="https://www.lungevity.org/for-patients-caregivers/survivor-resource-center/managing-treatment-side-effects" target="_blank">Learn more</a> <span class="text-primary"><strong>Get tips on managing treatment-related side effects.</strong></span></p><h2>How long do people with ALK-positive NSCLC take targeted therapy?</h2><p class="float-md-right text-center pl-md-3"><img src="/sites/default/files/inline-images/about-kras-4.jpg" data-entity-uuid="ae59e351-82c5-4123-b4cc-4f6ae3473248" data-entity-type="file" alt="Doctor and patient" width="426" height="260" loading="lazy"></p><p>Your cancer may be effectively managed with a targeted therapy for years with limited or no progression (cancer spread).</p><p>Unfortunately, after an initial positive response, many people with ALK+ NSCLC develop drug resistance to the therapy, meaning the drug stops working and their cancer begins to grow and spread again.</p><p>Luckily, ALK-positive NSCLC has a number of FDA-approved drugs, and patients are often able to switch to a different drug once one stops working. Your doctor will likely recommend a rebiopsy (a second biopsy of your tumor tissue) to determine what is causing your resistance before recommending another drug.</p><p>Many research efforts are underway to understand drug resistance and find ways to combat it. For example, researchers are looking at various drug combinations (using multiple drugs to treat your cancer) that may help delay or prevent resistance from happening.</p><p><a class="btn btn-secondary mr-3" href="https://alk.lungevity.org/leukemia-alk-nsclc-finding-new-way-overcome-drug-resistance" target="_blank">Read about</a> <span class="text-primary"><strong>recent efforts to combat drug resistance in ALK.</strong></span></p><p><a class="btn btn-secondary mr-3" href="https://alk.lungevity.org/innovative-therapeutic-vaccine-alk-nsclc-heads-phase-1-clinical-trial" target="_blank">Learn more</a> <span class="text-primary"><strong>about the latest advances toward ALK vaccine development.</strong></span></p><h2>Can people with ALK-positive lung cancer receive immunotherapy?</h2><p>ALK-positive NSCLC does not seem to respond to immunotherapy, which is a type of treatment that helps your immune system find and attack lung cancer. Researchers are actively exploring ways to open up immunotherapy options to patients with biomarker-driven NSCLC, including efforts to develop an ALK vaccine.</p><h2>What are other treatment options for ALK-positive NSCLC?</h2><p>Other treatment options include chemotherapy, radiation therapy, and clinical trials. Each time you have to make a new treatment decision, be sure to talk to your doctor about your options, including discussing your goals for the treatment and possible side effects of your options, to determine the best treatment option for you.</p><p>Talk with your doctor about your ALK mutation and your treatment options</p><p>Talk with your doctor to understand your ALK mutation and type of cancer, and to make a treatment plan together. Bring a pen and paper or use your cell phone to write down your questions and your doctor’s answers. You might start with these questions:</p><ul><li>Did I have comprehensive biomarker testing – which biomarkers did you check for? If not, can you order it?</li><li>What are my treatment options?<ul><li>Do I qualify for a clinical trial testing a new treatment for ALK mutation?</li><li>Is immunotherapy an option for me?</li><li>What are the possible side effects of these treatments?</li></ul></li><li>Do I have any other biomarkers that may change my treatment options?</li><li>What will we do if my treatment stops working?</li></ul><p><a class="btn btn-secondary mr-3" href="https://www.lungevity.org/for-patients-caregivers/navigating-your-diagnosis/biomarker-testing" target="_blank">Find More Questions</a> <span class="text-primary"><strong>to guide your discussions with your doctor.</strong></span></p><h2>How is NSCLC with ALK mutations treated?</h2><p>The treatment options for non-small cell lung cancer vary based on where the lung cancer is located within the lungs and the stage (whether the cancer has spread or not) of your NSCLC diagnosis. You will work with your doctor to decide on the treatment that is best for you, based on your type and stage of NSCLC and your biomarkers.</p><p>Below are some common treatment options for people with ALK-positive lung cancer.</p><nav class="nav nav-fill nav-tabs-gateway clear"><p class="row mx-0"><a class="nav-link active" href="#chemotherapy" aria-controls="chemotherapy" aria-selected="true" data-toggle="tab" id="chemotherapy-tab" role="tab">Chemotherapy</a> <a class="nav-link" href="#targeted" aria-controls="targeted" aria-selected="true" data-toggle="tab" id="targeted-tab" role="tab">Targeted therapy</a> <a class="nav-link" href="#immunotherapy" aria-controls="immunotherapy" aria-selected="true" data-toggle="tab" id="immunotherapy-tab" role="tab">Immunotherapy</a> <a class="nav-link" href="#trials" aria-controls="trials" aria-selected="true" data-toggle="tab" id="trials-tab" role="tab">Clinical trials</a> <a class="nav-link" href="#palliative" aria-controls="trials" aria-selected="true" data-toggle="tab" id="palliative-tab" role="tab">Palliative care</a></p></nav><div class="tab-content tab-content-gateway" id="tabContent"><div class="tab-pane fade show active" aria-labelledby="chemotherapy-tab" id="chemotherapy" role="tabpanel"><div class="tab-content-header-mobile" id="heading-AA" role="tab"><a href="#collapse-AA" aria-controls="collapse-AA" aria-expanded="true" data-parent="#content" data-toggle="collapse">Chemotherapy</a></div><div class="collapse show" aria-labelledby="heading-AA" data-parent=".tab-content-gateway" id="collapse-AA" role="tabpanel"><h2>Chemotherapy</h2><p>Chemotherapy is a treatment that uses drugs to stop the growth of cancer cells. Chemotherapy also attacks healthy cells.</p></div></div><div class="tab-pane fade" aria-labelledby="targeted-tab" id="targeted" role="tabpanel"><div class="tab-content-header-mobile" id="heading-B" role="tab"><a class="collapsed" href="#collapse-B" aria-controls="collapse-B" aria-expanded="false" data-parent="#content" data-toggle="collapse">Targeted therapy</a></div><div class="collapse" aria-labelledby="heading-B" data-parent=".tab-content-gateway" id="collapse-B" role="tabpanel"><div class="row"><div class="col-md-6"><h2>Targeted therapy</h2><p>Targeted therapy is a type of treatment that finds and attacks certain parts of cancer cells and the signals sent to cancer cells that cause them to grow uncontrolled. They prevent the growth of cancer cells only, and do not harm healthy cells.</p><p>A targeted therapy works to control a specific biomarker, so it can only treat patients with that specific biomarker.</p></div><div class="col-md-6"><div class="border mb-3"><div class="bg-gray text-white p-3"><span class="font-size-24">How targeted therapy works</span></div><div class="p-3 bg-white"><p>Targeted therapy attacks cancer cells only, and leaves healthy cells alone</p><img src="/sites/default/files/inline-images/about-kras-3.png" data-entity-uuid="dd2c74b6-bba7-4e38-bee2-8b01fae2f1d7" data-entity-type="file" alt="KRAS with gene mutation, More signals for cell growth, Cell growth is out of control and causes cancer" width="422" height="398" class="align-center" loading="lazy"></div></div></div></div></div></div><div class="tab-pane fade" aria-labelledby="immunotherapy-tab" id="immunotherapy" role="tabpanel"><div class="tab-content-header-mobile" id="heading-A" role="tab"><a class="collapsed" href="#collapse-C" aria-controls="collapse-C" aria-expanded="true" data-parent="#content" data-toggle="collapse">Immunotherapy</a></div><div class="collapse" aria-labelledby="heading-C" data-parent=".tab-content-gateway" id="collapse-C" role="tabpanel"><h2>Immunotherapy</h2><p>Immunotherapy is a type of treatment that helps your immune system find and attack lung cancer. It is already a standard of care treatment for some patients with ALK.</p><p>Many of the FDA-approved immunotherapies target another type of biomarker called PD-L1. Some people with ALK with biomarkers other than PD-L1 do not respond well to immunotherapy. Some people with ALK, however, have PD-L1 and other biomarkers. Clinical trials are now learning if immunotherapy could benefit these people.</p></div></div><div class="tab-pane fade" aria-labelledby="trials-tab" id="trials" role="tabpanel"><div class="tab-content-header-mobile" id="heading-D" role="tab"><a class="collapsed" href="#collapse-D" aria-controls="collapse-D" aria-expanded="true" data-parent="#content" data-toggle="collapse">Clinical trials</a></div><div class="collapse" aria-labelledby="heading-D" data-parent=".tab-content-gateway" id="collapse-D" role="tabpanel"><h2>Clinical trials</h2><p>Talk with your doctor about taking part in a clinical trial for a new, possible treatment. Clinical trials are an important option for people with ALK because the newest treatment approaches, not available otherwise, are being tested in them.</p><p>For example, researchers are currently testing cancer vaccines and lab-made immune system cells (cells that find and attack cancer) that will target driver mutations in ALK.</p></div></div><div class="tab-pane fade" aria-labelledby="palliative-tab" id="palliative" role="tabpanel"><div class="tab-content-header-mobile" id="heading-E" role="tab"><a class="collapsed" href="#collapse-E" aria-controls="collapse-E" aria-expanded="true" data-parent="#content" data-toggle="collapse">Palliative care</a></div><div class="collapse" aria-labelledby="heading-E" data-parent=".tab-content-gateway" id="collapse-E" role="tabpanel"><h2>Palliative care</h2><p>Palliative care does not treat lung cancer directly. The goal of palliative care is to improve your quality of life while receiving treatment. It prevents or treat the symptoms and side effects of the disease and its treatment. It also helps you manage emotional, social, practical, and spiritual problems you may face.</p></div></div></div><h2>Talk to your doctor to learn more about your type of cancer and treatment options</h2><p>Talk with your doctor to understand your type of lung cancer and to make a treatment plan together. Bring a pen and paper or use your cell phone to write down your questions and your doctor’s answers.</p><p>You might start with these questions:</p><ul><li>What type of lung cancer do I have?</li><li>What is the stage of my lung cancer and what does this mean for my treatment?</li><li>Did I have comprehensive biomarker testing – which biomarkers did you check for? If not, can you order it?</li><li>What are my treatment options?<ul><li>What biomarkers do I have?</li><li>Is immunotherapy an option for me?</li><li>What is a clinical trial and should I enter one?</li><li>What are the possible side effects of these treatments?</li></ul></li></ul><div class="d-flex align-items-center mb-3 p-3"><div><a href="/sites/default/files/2022-05/newly-diagnosed-alk-patients.pdf" aria-label="print" target="_blank"><img class="mr-3" src="/sites/default/files/inline-images/printer-icon.png" data-entity-uuid="7eeeb3fe-226d-4cec-914e-1b9306f6189b" data-entity-type="file" alt="printer icon" width="93" height="93" loading="lazy"></a></div><div class="border-top border-bottom p-3"><p>Tip: Print these questions out and fill in the answers with your doctor. Having this sheet on hand can help you to remember the conversation and plan for any next steps.</p></div></div><h2>Important Information for Patients with Newly Diagnosed ALK-Positive Lung Cancer</h2><p>In this presentation, Upal Basu Roy, PhD, MPH, LUNGevity's executive director of research, speaks with Justin Gainor, MD, about what people with newly diagnosed ALK-positive lung cancer should know. Dr. Gainor is director of the Center for Thoracic Cancers and director of targeted immunotherapy at Massachusetts General Hospital.</p><div class="width560"><video controls poster="https://lungevity.canto.com/direct/video/qcs4ieto0t42ffbdln9bc4ke5i/91rIsU16qiUV5C9aJR0NBJoxxdI/m800/800" width="100%"><source src="https://lungevity.canto.com/direct/video/qcs4ieto0t42ffbdln9bc4ke5i/91rIsU16qiUV5C9aJR0NBJoxxdI/play" type="video/mp4"></video></div></div> </div> </div> </div> </div> </article> <div class="mb-4 block block-block-content block-block-content26a2a02d-c1fb-43b1-9aae-1c17bd53278b" id="block-block-content-26a2a02d-c1fb-43b1-9aae-1c17bd53278b"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="d-flex flex-column flex-md-row align-items-center mt-4 d-print-none"> <div> <h2 class="highlight"><strong>News </strong>in the <strong>Community</strong></h2> </div> <div class="px-3"> <p>We make it easy for you to stay current with the latest news in lung cancer.</p> </div> <div><a class="btn btn-secondary mb-3" href="https://alk.lungevity.org/ALK/newsletters">Learn More</a></div> </div> </div> </div> <div id="block-externallinkpopup" class="block block-block-content block-block-content6b9081f8-11a1-40cf-bbca-223e27cfbe67"> <div class="modal fade" id="externallinkpopup" tabindex="-1" aria-labelledby="externallinkpopupLabel" aria-hidden="true"> <div class="modal-dialog modal-lg"> <div class="modal-content rounded-0"> <div class="modal-header border-0 rounded-0"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true"><i class="bi bi-x"></i></span> </button> </div> <div class="modal-body"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><h2 class="highlight text-align-center"><span class="font-size-24"><strong>You are about to leave</strong> the Patient Gateway</span></h2> <p class="text-align-center mb-4">You’re one click away from learning about one of our most valued sponsors. Read about how they’re making a difference in patients’ lives.</p> <p class="text-align-center"><a class="btn btn-secondary mr-3" href="#" id="external-proceed">Proceed</a><a class="btn btn-secondary" href="#" id="external-cancel">Cancel</a></p> </div> </div> </div> </div> </div> </div> <div class="views-element-container mb-4 block block-views block-views-blocklanding-page-grid-gateway-block-11" id="block-views-block-landing-page-grid-gateway-block-11"> <div><div class="view view-landing-page-grid-gateway view-id-landing_page_grid_gateway view-display-id-block_11 js-view-dom-id-fd0b271dfee93ca03f0bf1b99fb634e1afe838867288acbf7bb421b58a17c1e1"> <div class="container-fluid- page-inner-max-width- lp-container"> <div class="view-content row"> <div class="col-md-6 col-lg-4 views-row pg-lp-block-row nid-39"> <div class="pg-lp-block flex-column d-none d-md-flex"> <div class="pg-lp-block-overlay"></div> <div class="pg-lp-block-img" style="background-image:url(/sites/default/files/lp/alk-find-your-community-lp_0.jpg);"></div> <div class="pg-lp-block-body"><div class="views-field views-field-body"><div class="field-content"><h2>Find your <strong>Community</strong></h2> <p>Whether you're living with lung cancer, or caring for someone with the disease, online groups and biomarker-specific communities can offer much-needed support.</p></div></div><div class="views-field views-field-field-link-to-url-1"><div class="field-content"><div class="btn btn-secondary">Learn More</div></div></div></div> <a class="pg-lp-link" aria-label="ALK Find your Community -LP" href="/alk/find-your-community"></a> </div> </div> <a class="btn btn-secondary d-block d-md-none m-2" aria-label="ALK Find your Community -LP" href="/alk/find-your-community">Find your Community</a> <div class="col-md-6 col-lg-4 views-row pg-lp-block-row nid-40"> <div class="pg-lp-block flex-column d-none d-md-flex"> <div class="pg-lp-block-overlay"></div> <div class="pg-lp-block-img" style="background-image:url(/sites/default/files/lp/alk-clinical-trials-lp.jpg);"></div> <div class="pg-lp-block-body"><div class="views-field views-field-body"><div class="field-content"><h2>Learn about<br> <strong>Clinical Trials</strong></h2> <p>Participating in a research study may offer additional treatment options for those who are eligible.</p></div></div><div class="views-field views-field-field-link-to-url-1"><div class="field-content"><div class="btn btn-secondary">Learn More</div></div></div></div> <a class="pg-lp-link" aria-label="ALK Learn about Clinical Trials -LP" href="/alk/learn-about-clinical-trials"></a> </div> </div> <a class="btn btn-secondary d-block d-md-none m-2" aria-label="ALK Learn about Clinical Trials -LP" href="/alk/learn-about-clinical-trials">Learn about Clinical Trials</a> <div class="col-md-6 col-lg-4 views-row pg-lp-block-row nid-45"> <div class="pg-lp-block flex-column d-none d-md-flex"> <div class="pg-lp-block-overlay"></div> <div class="pg-lp-block-img" style="background-image:url(/sites/default/files/lp/alk-lp.jpg);"></div> <div class="pg-lp-block-body"><div class="views-field views-field-body"><div class="field-content"><h2>About <strong>ALK</strong></h2> <p>If you have ALK and your doctor told you that your cancer is ALK positive…</p></div></div><div class="views-field views-field-field-link-to-url-1"><div class="field-content"><div class="btn btn-secondary">Learn More</div></div></div></div> <a class="pg-lp-link" aria-label="About ALK - LP" href="/alk/about-alk-positive-lung-cancer"></a> </div> </div> <a class="btn btn-secondary d-block d-md-none m-2" aria-label="About ALK - LP" href="/alk/about-alk-positive-lung-cancer">About ALK</a> <div class="col-md-6 col-lg-4 views-row pg-lp-block-row nid-41"> <div class="pg-lp-block flex-column d-none d-md-flex"> <div class="pg-lp-block-overlay"></div> <div class="pg-lp-block-img" style="background-image:url(/sites/default/files/lp/alk-find-specilist-lp_0.jpg);"></div> <div class="pg-lp-block-body"><div class="views-field views-field-body"><div class="field-content"><h2>Find a <strong>Specialist</strong></h2> <p>Locate a healthcare provider who specializes in your specific type of cancer</p></div></div><div class="views-field views-field-field-link-to-url-1"><div class="field-content"><div class="btn btn-secondary">Learn More</div></div></div></div> <a class="pg-lp-link" aria-label="ALK - Find a Specialist - LP" href="/alk/find-specialist"></a> </div> </div> <a class="btn btn-secondary d-block d-md-none m-2" aria-label="ALK - Find a Specialist - LP" href="/alk/find-specialist">Find a Specialist</a> </div> </div> </div> </div> </div> <div class="mb-4 block block-block-content block-block-content48fffa77-1079-4e43-8e47-7375b75a2484" id="block-block-content-48fffa77-1079-4e43-8e47-7375b75a2484"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="d-print-none"><h2 class="highlight">Our<br><strong>Newsletters</strong></h2><p>Get the latest news in lung cancer—from research advances to virtual events—to help you manage your ALK diagnosis and treatment.</p><p><a class="btn btn-secondary" href="https://alk.lungevity.org/ALK/newsletters">READ MORE</a></p></div></div> </div> </div> </div> </div> </div> </main> </div> <div class="add-to-any-container"> <span><strong>SHARE</strong></span>  <div class="a2a_kit a2a_kit_size_32 a2a_default_style"> <a class="a2a_button_facebook"></a> <a class="a2a_button_twitter"></a> <a class="a2a_button_email"></a> </div> <script async src="https://static.addtoany.com/menu/page.js"></script>  </div> <footer aria-label="Site footer" class="footer" id="footer" role="contentinfo"> <div class="page-max-width container-fluid py-4"> <div class="region region-footer-content"> <div id="block-logosandaddress-2" class="block block-block-content block-block-contenta7412962-4103-4fc7-8cf7-c1edd5845d8c"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="font-size-20">The Patient Gateways are a project of LUNGevity Foundation, an organization transforming how people are diagnosed and live with lung cancer. <a href="https://www.lungevity.org/about-us" title="https://www.lungevity.org/about-us">Learn more here</a>.</p><p class="mb-0"><a href="https://www.lungevity.org/about-us/financial-legal-disclosures/privacy-policy">Privacy policy</a> <span class="mx-2">|</span> <a href="https://www.lungevity.org/about-us/contact-us">Contact us</a></p><p class="mb-0"> </p><p class="mb-0">This website is not intended to, and does not, provide medical advice, professional diagnosis, opinion, treatment, or services. 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