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Juvenile idiopathische Arthritis - Deutsches Zentrum Immuntherapie | Uniklinikum Erlangen
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href="https://www.dzi.uk-erlangen.de/patienten/chronisch-entzuendliche-erkrankungen/juvenile-idiopathische-arthritis/"/> </head> <body id="p1022746" class="page-1022746 pagelevel-3 language-0 backendlayout-default layout-default"> <div id="top"></div><div class="body-bg"><a class="visually-hidden-focusable page-skip-link" href="#page-content" tabindex="1"><span>Zum Hauptinhalt springen</span></a><a class="visually-hidden-focusable page-skip-link" href="#page-footer" tabindex="1"><span>Skip to page footer</span></a><header id="page-header" class="page-header"><div class="container header-container"><div class="row justify-content-between"><div class="col header-logo"><a title="Zur Startseite des Universit盲tsklinikums Erlangen" tabindex="2" href="https://www.uk-erlangen.de/"><img loading="lazy" title="Logo des Universit盲tsklinikums Erlangen" alt="Logo des Universit盲tsklinikums Erlangen" src="/_assets/ad9c8a6411247399e1e0e3c280c7c58e/Images/Uniklinikum-Erlangen.svg" width="262" 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data-bs-toggle="collapse" title="脰ffnet den Sprachumschalter, um eine andere Sprache zu w盲hlen."><span class="lang-DE"></span><span class="icon icon-arrow_right d-none d-md-inline-block"></span></a></li><li class=" collapse"><a href="/en/patienten/translate-to-en-chronisch-entzuendliche-erkrankungen/translate-to-en-juvenile-idiopathische-arthritis/" hreflang="en-US" title="View this page in English."><span class="lang-EN"></span></a></li><li class="text-muted collapse"></li><li class="text-muted collapse"></li></ul></div></nav><div class="header-info-accessibility"><nav id="info-navigation" class="navbar-info"><ul class="navbar__list"><li class="navbar__item flag"><a class="navbar-info__emergency text-danger" tabindex="3" href="/notfall/"><span> Notfall </span></a></li><li class="navbar__item flag "><a href="https://www.uk-erlangen.de/einrichtungen/klinikumsvorstand/qualitaetsmanagement/lob-und-kritik/" title="Lob und Kritik"><span>Lob und Kritik</span></a></li><li class="navbar__item 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Anpassung der Schriftgr枚脽e zeigen" title="Hinweise f眉r die Anpassung der Schriftgr枚脽e zeigen" ><span class="icon icon--fontsize"></span></button></et-popover-trigger><et-popover-content><dialog class="popover-dialog" aria-label="Hinweise f眉r die Anpassung der Schriftgr枚脽e" ><form method="dialog"><button class="button close" aria-label="Schlie脽en" ><svg xmlns="http://www.w3.org/2000/svg" width="28" height="28" fill="currentColor" class="bi bi-x-lg" viewBox="0 0 16 16"><path d="M2.146 2.854a.5.5 0 1 1 .708-.708L8 7.293l5.146-5.147a.5.5 0 0 1 .708.708L8.707 8l5.147 5.146a.5.5 0 0 1-.708.708L8 8.707l-5.146 5.147a.5.5 0 0 1-.708-.708L7.293 8z"/></svg></button></form><div class="popover-dialog__content"><h3>Schriftgr枚脽e anpassen</h3><p><b>F眉r Windows / Linux:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Strg] - [+]: Schrift vergr枚脽ern</li><li>[Strg] - [-]: Schrift verkleinern</li><li>[Strg] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul><br><p><b>F眉r Mac:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Cmd] - [+]: Schrift vergr枚脽ern</li><li>[Cmd] - [-]: Schrift verkleinern</li><li>[Cmd] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul></div><et-popover-arrow></et-popover-arrow></dialog></et-popover-content></et-popover-root></li></ul></nav></div></div></div></div><div class="menu-main-container bg-blue-darkest"><div class="main-navigation-button-container frame-container frame-container-default d-md-none"><button class="btn main-navigation-button p-4" type="button" data-bs-toggle="offcanvas" data-bs-target="#main-navigation" aria-controls="main-navigation" aria-label="Men眉 枚ffnen" ><span class="burger-icon"></span></button></div><nav id="main-navigation" tabindex="-1" class="navbar navbar-main frame-container frame-container-default offcanvas offcanvas-start" ><button type="button" class="btn-close btn-close-white text-reset 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href="/en/patienten/translate-to-en-chronisch-entzuendliche-erkrankungen/translate-to-en-juvenile-idiopathische-arthritis/" hreflang="en-US" title="View this page in English."><span class="lang-EN"></span></a></li><li class="text-muted collapse"></li><li class="text-muted collapse"></li></ul></div></div><div class="d-md-none navbar-info p-3 pt-0"><ul class="navbar__list"><li class="navbar__item flag"><a class="navbar-info__emergency text-danger" tabindex="3" href="/notfall/"><span> Notfall </span></a></li><li class="navbar__item flag "><a href="https://www.uk-erlangen.de/einrichtungen/klinikumsvorstand/qualitaetsmanagement/lob-und-kritik/" title="Lob und Kritik"><span>Lob und Kritik</span></a></li><li class="navbar__item flag "><a href="/legal-footer-menu/kontakt/" title="Kontakt"><span>Kontakt</span></a></li><li class="navbar__item flag "><a href="/anfahrt/" title="Anfahrt"><span>Anfahrt</span></a></li></ul></div></nav></div></header><div class="frame-container frame-container-large frame-type-intro-bg"><div class="ratio ratio-5x1"><div class="frame-has-backgroundimage"><div class="frame-backgroundimage-container"><div id="frame-backgroundimage-1022746" class="frame-backgroundimage"></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>Juvenile idiopathische Arthritis</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></a></li><li class="breadcrumb-item icon-arrow_right"><a class="breadcrumb-link" href="/" title="Deutsches Zentrum Immuntherapie"><span class="breadcrumb-text">Deutsches Zentrum Immuntherapie</span></a></li><li class="breadcrumb-item icon-arrow_right "><a class="breadcrumb-link" href="/patienten/" title="Patienten"><span class="breadcrumb-text">Patienten</span></a></li><li class="breadcrumb-item icon-arrow_right "><a class="breadcrumb-link" href="/patienten/chronisch-entzuendliche-erkrankungen/" title="Akut- und chronisch-entz眉ndliche Erkrankungen"><span class="breadcrumb-text">Akut- und chronisch-entz眉ndliche Erkrankungen</span></a></li><li class="breadcrumb-item icon-arrow_right active" aria-current="page"><span class="breadcrumb-text">Juvenile idiopathische Arthritis</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><!--TYPO3SEARCH_begin--><div class="section section-before-content"></div><div class="section section-default"><div id="c75880" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Juvenile Idiopathische Arthritis</span></h2></div><p>Bei der juvenilen idiopathischen Arthritis, kurz JIA, handelt es sich um eine chronische rheumatische Autoimmunerkrankung, die die Gelenke betrifft. Unter Autoimmunerkrankungen werden Erkrankungen verstanden, bei denen sich das Immunsystem nicht mehr nur gegen Krankheitserreger richtet, sondern auch gegen den eigenen K枚rper. Bei der JIA wandern fehlgeleitetet Abwehrzellen in die Gelenke ein und produzieren hier entz眉ndungsf枚rdernde Botenstoffe. Wird diese 脺berreaktion des Immunsystems nicht rechtzeitig erkannt und behandelt, werden die Gelenke langsam zerst枚rt.<br><br> Definitionsgem盲脽 tritt die idiopathische Arthritis vor dem 16. Lebensjahr auf. Eine Krankheit liegt vor, wenn die Entz眉ndung der Gelenke mindestens 6 Wochen anh盲lt und gleichzeitig andere Ursachen ausgeschlossen werden k枚nnen. Je nach den Symptomen au脽erhalb der Gelenke und der Anzahl der betroffenen Gelenke werden sieben Unterformen unterschieden:<br><br><strong>Systemische Arthritis:</strong><br> - auch Organe wie Leber, Herz, Lymphknoten und Lunge betroffen<br><br><strong>Rheumafaktor-positive Polyarthritis:</strong><br> - 5 oder mehr Gelenke betroffen<br> - Rheumafaktor (spezieller Antik枚rper) im Blut nachweisbar<br> - der rheumatoiden Arthritis der Erwachsenen 盲hnlich<br> - meist im sp盲ten Kindesalter<br><br><strong>Rheumafaktor-negative Polyarthritis:</strong><br> - 5 oder mehr Gelenke betroffen<br> - kein Rheumafaktor nachweisbar<br> - meist im Kleinkindalter<br><br><strong>Enthesitis-assoziierte Arthritis:</strong><br> - betrifft Sehnenans盲tze und Gelenke<br> - bestimmter Zellmarker HLA-B27 vorhanden<br> - meist im sp盲ten Kindesalter<br><br><strong>Oligoarthritis:</strong><br> - zu Beginn 4 oder weniger Gelenke betroffen<br> - meist im Kleinkindalter<br><br><strong>Psoriasis-Arthritis:</strong><br> - assoziiert mit Psoriasis (Schuppenflechte)<br> - am h盲ufigsten Kniegelenke betroffen<br> - isolierter Befall einer einzelnen Zehe typisch<br><br><strong>Undifferenzierte Arthritis:</strong><br> - keine oder mehr als einer der 眉brigen Formen<br><br><br> </p></div></div></div></div></div><div id="c80787" class=" frame frame-default frame-type-accordion frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="accordion " id="accordion-80787"><div class="accordion-item"><h4 class="accordion-header" id="accordion-heading-80787-495"><a href="#accordion-80787-495" class="accordion-button collapsed js-accordion-title-link" data-bs-toggle="collapse" data-bs-target="#accordion-80787-495" data-bs-parent="#accordion-80787" aria-expanded="false" aria-controls="accordion-80787-495" > Welche Ursachen hat juvenile idiopathische Arthritis? </a></h4><div id="accordion-80787-495" class="accordion-collapse collapse" aria-labelledby="accordion-heading-80787-495" data-bs-parent="#accordion-80787"><div class="accordion-body"><div class="accordion-content accordion-content-left"><div class="accordion-content-item accordion-content-text"><p>Die Ursache der juvenilen idiopathischen Arthritis konnte bisher noch nicht abschlie脽end gekl盲rt werden. Jedoch gehen Experten davon aus, dass bei einer vorhandenen genetischen Disposition bestimmte Autoimmunmechanismen den Ausbruch der Erkrankung beg眉nstigen k枚nnen. Wahrscheinlich spielen auch 盲u脽ere Faktoren wie Umwelteinfl眉sse oder virale und bakterielle Infektionen eine Rolle, die die Krankheit jedoch weniger beeinflussen.<br><br> </p></div></div></div></div></div><div class="accordion-item"><h4 class="accordion-header" id="accordion-heading-80787-497"><a href="#accordion-80787-497" class="accordion-button collapsed js-accordion-title-link" data-bs-toggle="collapse" data-bs-target="#accordion-80787-497" data-bs-parent="#accordion-80787" aria-expanded="false" aria-controls="accordion-80787-497" > Symptome: Welche Beschwerden sind f眉r die juvenile idiopathische Arthritis typisch? </a></h4><div id="accordion-80787-497" class="accordion-collapse collapse" aria-labelledby="accordion-heading-80787-497" data-bs-parent="#accordion-80787"><div class="accordion-body"><div class="accordion-content accordion-content-left"><div class="accordion-content-item accordion-content-text"><p>Die Beschwerden der Patienten variieren je nach Erscheinungsform der Krankheit und sind individuell sehr unterschiedlich ausgepr盲gt. Das Spektrum reicht dabei von Schwellungen und Schmerzen der Gelenke bis hin zu Fieberschu虉ben, Hautauschla虉gen und Augenentzu虉ndungen.<br><br> Folgende Symptome treten bei der juvenilen idiopathischen Arthritis haupts盲chlich auf:<br> - R枚tungen der Haut an den betroffenen Gelenken<br> - Schmerzen der Gelenke<br> - Augenentz眉ndung (h盲ufig bei Oligoarthritis)<br> - Morgensteifigkeit<br> - Fiebersch眉be<br> - Hautanomalien (h盲ufig bei Psoriasis-Arthritis und systemischer Arthritis)<br> - Bewegungseinschr盲nkung<br> - 脺berw盲rmung<br> - sichtbare und/oder tastbare Schwellungen (Gelenkerg眉sse sonografisch detektierbar)<br> - schnellere Erm眉dung<br> - Leistungsabfall<br> - Wachstumsst枚rungen an den entz眉ndeten Gelenken, die zu Fehlstellungen f眉hren k枚nnen<br><br> </p></div></div></div></div></div><div class="accordion-item"><h4 class="accordion-header" id="accordion-heading-80787-499"><a href="#accordion-80787-499" class="accordion-button collapsed js-accordion-title-link" data-bs-toggle="collapse" data-bs-target="#accordion-80787-499" data-bs-parent="#accordion-80787" aria-expanded="false" aria-controls="accordion-80787-499" > Behandlung - wie kann mir das Deutsche Zentrum Immuntherapie helfen? </a></h4><div id="accordion-80787-499" class="accordion-collapse collapse" aria-labelledby="accordion-heading-80787-499" data-bs-parent="#accordion-80787"><div class="accordion-body"><div class="accordion-content accordion-content-left"><div class="accordion-content-item accordion-content-text"><p>Die Behandlung der juvenilen idiopathischen Arthritis erfolgt bis zum 18. Lebensjahr an der Kinderklinik des Universit盲tsklinikums Erlangen. Als Teil des Deutschen Zentrum Immuntherapie steht unseren Patienten hier ein interdisziplin盲res Team aus Spezialisten verschiedener Fachrichtungen zur Seite.<br><br> Neben den bew盲hrten Therapien mit Standardmedikationen wie Methotrexat haben Patienten am DZI Zugang zu weitere hochmoderne Therapiem枚glichkeiten. Hierzu geh枚ren auch verschiedene Formen der Immuntherapie. Die Behandlung der juvenilen idiopathischen Arthritis kann durch die gezielte Gabe von Biologika erfolgen. Dabei handelt es sich um neuartige Biopharmazeutika, die mit Hilfe biotechnologischer Verfahren hergestellt werden und die die der Krankheit zugrunde liegende 眉berschie脽ende Aktivierung des Immunsystems hemmen sollen.<br><br> Die Medikamente k枚nnen in Form von Infusionen im Rahmen von tagesstation盲ren Aufenthalten oder subkutan in der Ambulanz verabreicht werden. Nach entsprechender Schulung der Patienten ist die subkutane Anwendung auch zu Hause m枚glich.<br><br> Je nach Beschwerdesymptomatik erfolgen parallel weitere 盲rztliche Konsultationen. Im Hauptfokus steht hierbei die enge Verzahnung mit internen Abteilungen wie der Kindernephrologie, der Kindergastroenterologie oder anderen universit盲ren Einrichtungen wie zum Beispiel der Augenklinik, der Hautklinik oder der Radiologie.<br><br> Mit der Erwachsenenrheumatologie visitieren wir gemeinsam Eltern mit deren Kindern. In unserer hoch spezialisierten Transitionssprechstunde nehmen wir uns ausreichend Zeit zur Beantwortung medizinischer und sozialrechtlicher Fragen, um den 脺bergang von der Kinderheilkunde in die Erwachsenenmedizin so einfach wie m枚glich zu gestalten. Da sich bei autoinflammatorische Erkrankungen oft eine famili盲re H盲ufung zeigt, ist die Zusammenarbeit und Betreuung im interdisziplin盲ren Team aus Kinder- und Erwachsenenrheumatologie von besonderer Bedeutung und in dieser Form einzigartig in der Region..<br><br> Durch den Zusammenschluss der beteiligten Fachbereiche am DZI k枚nnen Patienten effektiv und z眉gig an die richtigen 盲rztlichen Ansprechpartner verwiesen werden. Au脽erdem profitieren sie von neuesten wissenschaftlichen Forschungsergebnissen, die im Rahmen von Studien angewendet und stetig weiterentwickelt werden.<br><br> Haben Sie Fragen zur Behandlung von juveniler idiopathischer Arthritis? Kontaktieren Sie uns gerne per Telefon, per E-Mail oder 眉ber unser Kontaktformular.</p></div></div></div></div></div><div class="accordion-item"><h4 class="accordion-header" id="accordion-heading-80787-1889"><a href="#accordion-80787-1889" class="accordion-button collapsed js-accordion-title-link" data-bs-toggle="collapse" data-bs-target="#accordion-80787-1889" data-bs-parent="#accordion-80787" aria-expanded="false" aria-controls="accordion-80787-1889" > Patienten-Informationsvideo "Moderne Therapie bei rheumatoider Arthritis am DZI" </a></h4><div id="accordion-80787-1889" class="accordion-collapse collapse" aria-labelledby="accordion-heading-80787-1889" data-bs-parent="#accordion-80787"><div class="accordion-body"><div class="accordion-content accordion-content-left"><div class="accordion-content-item accordion-content-text"><p><a href="https://www.youtube.com/watch?v=m_eeja_e5Rk&list=PLL_Pg5EvHswZt9qhIFTUNXEy1VWNagKl6&index=14" target="_blank" class="link link-external" rel="noreferrer">Hier geht es zum Video</a></p></div></div></div></div></div></div></div></div></div></div></div><div id="c82846" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Kooperationspartner</span></h3></div><p><a href="https://www.kinderklinik.uk-erlangen.de/" target="_blank" class="link link-external">Kinderklinik</a></p></div></div></div></div></div><div id="c84338" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div 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