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<button class="button is-small is-link">Go</button> </div> </div> </form> </div> </div> <ol class="breathe-horizontal" start="1"> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1602.03493">arXiv:1602.03493</a> <span> [<a href="https://arxiv.org/pdf/1602.03493">pdf</a>, <a href="https://arxiv.org/format/1602.03493">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Neurons and Cognition">q-bio.NC</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1109/CISS.2016.7460563">10.1109/CISS.2016.7460563 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Winning versus losing during gambling and its neural correlates </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&query=Sacr%C3%A9%2C+P">Pierre Sacr茅</a>, <a href="/search/q-bio?searchtype=author&query=Kerr%2C+M+S+D">Matthew S. D. Kerr</a>, <a href="/search/q-bio?searchtype=author&query=Subramanian%2C+S">Sandya Subramanian</a>, <a href="/search/q-bio?searchtype=author&query=Kahn%2C+K">Kevin Kahn</a>, <a href="/search/q-bio?searchtype=author&query=Gonzalez-Martinez%2C+J">Jorge Gonzalez-Martinez</a>, <a href="/search/q-bio?searchtype=author&query=Johnson%2C+M+A">Matthew A. Johnson</a>, <a href="/search/q-bio?searchtype=author&query=Gale%2C+J+T">John T. Gale</a>, <a href="/search/q-bio?searchtype=author&query=Sarma%2C+S+V">Sridevi V. Sarma</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1602.03493v1-abstract-short" style="display: inline;"> Humans often make decisions which maximize an internal utility function. For example, humans often maximize their expected reward when gambling and this is considered as a "rational" decision. However, humans tend to change their betting strategies depending on how they "feel". If someone has experienced a losing streak, they may "feel" that they are more likely to win on the next hand even though… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1602.03493v1-abstract-full').style.display = 'inline'; document.getElementById('1602.03493v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1602.03493v1-abstract-full" style="display: none;"> Humans often make decisions which maximize an internal utility function. For example, humans often maximize their expected reward when gambling and this is considered as a "rational" decision. However, humans tend to change their betting strategies depending on how they "feel". If someone has experienced a losing streak, they may "feel" that they are more likely to win on the next hand even though the odds of the game have not changed. That is, their decisions are driven by their emotional state. In this paper, we investigate how the human brain responds to wins and losses during gambling. Using a combination of local field potential recordings in human subjects performing a financial decision-making task, spectral analyses, and non-parametric cluster statistics, we investigated whether neural responses in different cognitive and limbic brain areas differ between wins and losses after decisions are made. In eleven subjects, the neural activity modulated significantly between win and loss trials in one brain region: the anterior insula ($p=0.01$). In particular, gamma activity (30-70 Hz) increased in the anterior insula when subjects just realized that they won. Modulation of metabolic activity in the anterior insula has been observed previously in functional magnetic resonance imaging studies during decision making and when emotions are elicited. However, our study is able to characterize temporal dynamics of electrical activity in this brain region at the millisecond resolution while decisions are made and after outcomes are revealed. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1602.03493v1-abstract-full').style.display = 'none'; document.getElementById('1602.03493v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 10 February, 2016; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> February 2016. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1507.02716">arXiv:1507.02716</a> <span> [<a href="https://arxiv.org/pdf/1507.02716">pdf</a>, <a href="https://arxiv.org/format/1507.02716">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Neurons and Cognition">q-bio.NC</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1109/EMBC.2015.7319444">10.1109/EMBC.2015.7319444 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Electrical neurostimulation for chronic pain: on selective relay of sensory neural activities in myelinated nerve fibers </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&query=Sacr%C3%A9%2C+P">Pierre Sacr茅</a>, <a href="/search/q-bio?searchtype=author&query=Sarma%2C+S+V">Sridevi V. Sarma</a>, <a href="/search/q-bio?searchtype=author&query=Guan%2C+Y">Yun Guan</a>, <a href="/search/q-bio?searchtype=author&query=Anderson%2C+W+S">William S. Anderson</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1507.02716v1-abstract-short" style="display: inline;"> Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their mechanisms of action are unclear. Yet current computational models of pain transmission suffer from several limitations. In particular, dorsal column models do not i… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1507.02716v1-abstract-full').style.display = 'inline'; document.getElementById('1507.02716v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1507.02716v1-abstract-full" style="display: none;"> Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their mechanisms of action are unclear. Yet current computational models of pain transmission suffer from several limitations. In particular, dorsal column models do not include the fundamental underlying sensory activity traveling in these nerve fibers. We developed a (simple) simulation test bed of electrical neurostimulation of myelinated nerve fibers with underlying sensory activity. This paper reports our findings so far. Interactions between stimulation-evoked and underlying activities are mainly due to collisions of action potentials and losses of excitability due to the refractory period following an action potential. In addition, intuitively, the reliability of sensory activity decreases as the stimulation frequency increases. This first step opens the door to a better understanding of pain transmission and its modulation by neurostimulation therapies. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1507.02716v1-abstract-full').style.display = 'none'; document.getElementById('1507.02716v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 9 July, 2015; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> July 2015. </p> </li> </ol> <div class="is-hidden-tablet">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 2020-02-24</a>  </span> </div> </div> </main> <footer> <div class="columns is-desktop" role="navigation" aria-label="Secondary">  <div class="column"> <div class="columns"> <div class="column"> <ul class="nav-spaced"> <li><a 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