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.infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Difelikefalin">Difelikefalin</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Difelikefalin.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Difelikefalin.svg/250px-Difelikefalin.svg.png" decoding="async" width="250" height="124" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Difelikefalin.svg/375px-Difelikefalin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/33/Difelikefalin.svg/500px-Difelikefalin.svg.png 2x" data-file-width="2410" data-file-height="1195" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Korsuva</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">CR845, FE-202845, D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid]<sup id="cite_ref-pmid20030621_1-0" class="reference"><a href="#cite_note-pmid20030621-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Difelikefalin">Difelikefalin</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> B1<sup id="cite_ref-Korsuva_APMDS_2-0" class="reference"><a href="#cite_note-Korsuva_APMDS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection">Intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/Kappa_opioid_receptor_agonist" class="mw-redirect" title="Kappa opioid receptor agonist">Kappa opioid receptor agonist</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_V03" title="ATC code V03">V03AX04</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=V03AX04">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-Korsuva_APMDS_2-1" class="reference"><a href="#cite_note-Korsuva_APMDS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-Korsuva_FDA_label_8-0" class="reference"><a href="#cite_note-Korsuva_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-Kapruvia_EPAR_9-0" class="reference"><a href="#cite_note-Kapruvia_EPAR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">100% (<a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection">IV</a>)<sup id="cite_ref-SinatraJahr2010_10-0" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data">Not metabolized<sup id="cite_ref-SinatraJahr2010_10-3" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">2 hours<sup id="cite_ref-SinatraJahr2010_10-1" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">Excreted as unchanged<br />drug via <a href="/wiki/Bile" title="Bile">bile</a> and <a href="/wiki/Urine" title="Urine">urine</a><sup id="cite_ref-SinatraJahr2010_10-2" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1024828-77-0">1024828-77-0</a></span></li><li>as salt: <span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1024829-44-4">1024829-44-4</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/24794466">24794466</a></span></li><li>as salt: <span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/91864509">91864509</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB11938">DB11938</a></span></li><li>as salt: <span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DBSALT003191">DBSALT003191</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.44208824.html">44208824</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/NA1U919MRO">NA1U919MRO</a></span></li><li>as salt: <span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/0P70AR5BYB">0P70AR5BYB</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D11111">D11111</a></span></li><li>as salt: <span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D10890">D10890</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL3989915">ChEMBL3989915</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID401032896">DTXSID401032896</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q21098992#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>36</sub><span title="Hydrogen">H</span><sub>53</sub><span title="Nitrogen">N</span><sub>7</sub><span title="Oxygen">O</span><sub>6</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002679863000000000♠"></span>679.863</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CC%28C%29C%5BC%40H%5D%28C%28%3DO%29N%5BC%40H%5D%28CCCCN%29C%28%3DO%29N1CCC%28CC1%29%28C%28%3DO%29O%29N%29NC%28%3DO%29%5BC%40%40H%5D%28CC2%3DCC%3DCC%3DC2%29NC%28%3DO%29%5BC%40%40H%5D%28CC3%3DCC%3DCC%3DC3%29N">Interactive image</a></span></li><li>as salt: <span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CC%28O%29%3DO.CC%28C%29C%5BC%40%40H%5D%28NC%28%3DO%29%5BC%40%40H%5D%28CC1%3DCC%3DCC%3DC1%29NC%28%3DO%29%5BC%40H%5D%28N%29CC1%3DCC%3DCC%3DC1%29C%28%3DO%29N%5BC%40H%5D%28CCCCN%29C%28%3DO%29N1CCC%28N%29%28CC1%29C%28O%29%3DO">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N</div></li><li style="line-height: inherit; margin: 0"><br /><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">as salt: CC(O)=O.CC(C)C[C@@H](NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](N)CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:FWMNVWWHGCHHJJ-SKKKGAJSSA-N</div></li><li style="line-height: inherit; margin: 0"><br /><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">as salt: InChI=1S/C36H53N7O6.C2H4O2/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25;1-2(3)4/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49);1H3,(H,3,4)/t27-,28-,29-,30-;/m1./s1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:MZWHRPKAHCWTOI-KGURMGBCSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Difelikefalin</b>, sold under the brand name <b>Korsuva</b>, is an <a href="/wiki/Opioid_peptide" title="Opioid peptide">opioid peptide</a> used for the treatment of moderate to severe <a href="/wiki/Pruritus" class="mw-redirect" title="Pruritus">itch</a>. It acts as a <a href="/wiki/Peripherally_selective_drug" title="Peripherally selective drug">peripherally-restricted</a>, highly selective <a href="/wiki/Agonist" title="Agonist">agonist</a> of the <a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid receptor</a> (KOR).<sup id="cite_ref-SinatraJahr2010_10-4" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Apfelbaum2014_11-0" class="reference"><a href="#cite_note-Apfelbaum2014-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-CowanYosipovitch2015_12-0" class="reference"><a href="#cite_note-CowanYosipovitch2015-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Allerton2013_13-0" class="reference"><a href="#cite_note-Allerton2013-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Difelikefalin acts as an analgesic by activating KORs on peripheral <a href="/wiki/Nerve_terminal" class="mw-redirect" title="Nerve terminal">nerve terminals</a> and KORs expressed by certain <a href="/wiki/Immune_system" title="Immune system">immune system</a> <a href="/wiki/Immune_cell" class="mw-redirect" title="Immune cell">cells</a>.<sup id="cite_ref-SinatraJahr2010_10-5" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Activation of KORs on peripheral nerve terminals results in the inhibition of <a href="/wiki/Ion_channel" title="Ion channel">ion channels</a> responsible for <a href="/wiki/Afferent_nerve_fiber" title="Afferent nerve fiber">afferent</a> <a href="/wiki/Neurotransmission" title="Neurotransmission">nerve activity</a>, causing reduced transmission of pain signals, while activation of KORs expressed by immune system cells results in reduced release of <a href="/wiki/Proinflammatory" class="mw-redirect" title="Proinflammatory">proinflammatory</a>, <a href="/wiki/Nociceptor#Sensitivity" title="Nociceptor">nerve-sensitizing</a> mediators (e.g., <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandins</a>).<sup id="cite_ref-SinatraJahr2010_10-6" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Difelikefalin was approved for medical use in the United States in August 2021.<sup id="cite_ref-Korsuva_FDA_label_8-1" class="reference"><a href="#cite_note-Korsuva_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> The U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> considers it to be a <a href="/wiki/First-in-class_medication" title="First-in-class medication">first-in-class medication</a>.<sup id="cite_ref-New_Drug_Therapy_Approvals_2021_16-0" class="reference"><a href="#cite_note-New_Drug_Therapy_Approvals_2021-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Difelikefalin&action=edit&section=1" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Legal_status">Legal status</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Difelikefalin&action=edit&section=2" title="Edit section: Legal status"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>On 24 February 2022, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Kapruvia, intended for treatment of moderate-to-severe pruritus associated with chronic kidney disease.<sup id="cite_ref-Kapruvia:_Pending_EC_decision_17-0" class="reference"><a href="#cite_note-Kapruvia:_Pending_EC_decision-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> The applicant for this medicinal product is Vifor Fresenius Medical Care Renal Pharma France.<sup id="cite_ref-Kapruvia:_Pending_EC_decision_17-1" class="reference"><a href="#cite_note-Kapruvia:_Pending_EC_decision-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Difelikefalin was approved for medical use in the European Union in April 2022.<sup id="cite_ref-Kapruvia_EPAR_9-1" class="reference"><a href="#cite_note-Kapruvia_EPAR-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Difelikefalin&action=edit&section=3" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It is under development by <a href="/w/index.php?title=Cara_Therapeutics&action=edit&redlink=1" class="new" title="Cara Therapeutics (page does not exist)">Cara Therapeutics</a> as an <a href="/wiki/Intravenous_administration" class="mw-redirect" title="Intravenous administration">intravenous</a> agent for the treatment of <a href="/wiki/Postoperative_pain" class="mw-redirect" title="Postoperative pain">postoperative pain</a>.<sup id="cite_ref-SinatraJahr2010_10-7" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Apfelbaum2014_11-1" class="reference"><a href="#cite_note-Apfelbaum2014-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Allerton2013_13-1" class="reference"><a href="#cite_note-Allerton2013-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> An <a href="/wiki/Oral_administration" title="Oral administration">oral</a> formulation has also been developed.<sup id="cite_ref-Allerton2013_13-2" class="reference"><a href="#cite_note-Allerton2013-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Due to its peripheral selectivity, difelikefalin lacks the <a href="/wiki/Central_nervous_system" title="Central nervous system">central</a> <a href="/wiki/Side_effect" title="Side effect">side effects</a> like <a href="/wiki/Sedation" title="Sedation">sedation</a>, <a href="/wiki/Dysphoria" title="Dysphoria">dysphoria</a>, and <a href="/wiki/Hallucination" title="Hallucination">hallucinations</a> of previous KOR-acting analgesics such as <a href="/wiki/Pentazocine" title="Pentazocine">pentazocine</a> and <a href="/wiki/Phenazocine" title="Phenazocine">phenazocine</a>.<sup id="cite_ref-SinatraJahr2010_10-8" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Apfelbaum2014_11-2" class="reference"><a href="#cite_note-Apfelbaum2014-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> In addition to use as an analgesic, difelikefalin is also being investigated for the treatment of <a href="/wiki/Pruritus" class="mw-redirect" title="Pruritus">pruritus</a> (itching).<sup id="cite_ref-SinatraJahr2010_10-9" class="reference"><a href="#cite_note-SinatraJahr2010-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Apfelbaum2014_11-3" class="reference"><a href="#cite_note-Apfelbaum2014-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-CowanYosipovitch2015_12-1" class="reference"><a href="#cite_note-CowanYosipovitch2015-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Difelikefalin has completed <a href="/wiki/Phases_of_clinical_research#Phase_II" title="Phases of clinical research">phase II</a> <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trials</a> for postoperative pain and has demonstrated significant and "robust" clinical efficacy, along with being safe and well tolerated.<sup id="cite_ref-Apfelbaum2014_11-4" class="reference"><a href="#cite_note-Apfelbaum2014-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Allerton2013_13-3" class="reference"><a href="#cite_note-Allerton2013-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> It has also completed a phase III clinical trial for <a href="/wiki/Uremic_pruritus" title="Uremic pruritus">uremic pruritus</a> in <a href="/wiki/Hemodialysis" title="Hemodialysis">hemodialysis</a> patients.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Difelikefalin&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-pmid20030621-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20030621_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFJaneckaPerlikowskaGachWyrebska2010" class="citation journal cs1">Janecka A, Perlikowska R, Gach K, 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(August 2024)">bare URL</span></a></i>]</sup></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://pdf.hres.ca/dpd_pm/00066996.PDF">"Product monograph"</a> <span class="cs1-format">(PDF)</span>. <i><a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20221001060048/https://pdf.hres.ca/dpd_pm/00066996.PDF">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 1 October 2022<span class="reference-accessdate">. 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Retrieved <span class="nowrap">3 March</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Details+for%3A+Korsuva&rft.date=2023-02-06&rft_id=https%3A%2F%2Fdhpp.hpfb-dgpsa.ca%2Fdhpp%2Fresource%2F101892&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-Korsuva_FDA_label-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-Korsuva_FDA_label_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Korsuva_FDA_label_8-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c7b81f2-0fd3-47cb-8b0f-185e07f19c87">"Korsuva- difelikefalin injection, solution"</a>. <i>DailyMed</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210912221530/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c7b81f2-0fd3-47cb-8b0f-185e07f19c87">Archived</a> from the original on 12 September 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">12 September</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Korsuva-+difelikefalin+injection%2C+solution&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3D0c7b81f2-0fd3-47cb-8b0f-185e07f19c87&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-Kapruvia_EPAR-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-Kapruvia_EPAR_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Kapruvia_EPAR_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/kapruvia">"Kapruvia EPAR"</a>. <i><a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA)</i>. 22 February 2022. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220506032536/https://www.ema.europa.eu/en/medicines/human/EPAR/kapruvia">Archived</a> from the original on 6 May 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">28 April</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency+%28EMA%29&rft.atitle=Kapruvia+EPAR&rft.date=2022-02-22&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Fkapruvia&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-SinatraJahr2010-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-SinatraJahr2010_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-SinatraJahr2010_10-9"><sup><i><b>j</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChalmers2010" class="citation book cs1">Chalmers D (14 October 2010). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=ZwPIjKg0XukC&pg=PA490">"Peripheral kappa agonists"</a>. In Sinatra RS, Jahr JS, Watkins-Pitchford JM (eds.). <i>The Essence of Analgesia and Analgesics</i>. Cambridge University Press. pp. 490–491. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-139-49198-3" title="Special:BookSources/978-1-139-49198-3"><bdi>978-1-139-49198-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Peripheral+kappa+agonists&rft.btitle=The+Essence+of+Analgesia+and+Analgesics&rft.pages=490-491&rft.pub=Cambridge+University+Press&rft.date=2010-10-14&rft.isbn=978-1-139-49198-3&rft.aulast=Chalmers&rft.aufirst=D&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DZwPIjKg0XukC%26pg%3DPA490&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-Apfelbaum2014-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-Apfelbaum2014_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Apfelbaum2014_11-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Apfelbaum2014_11-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Apfelbaum2014_11-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Apfelbaum2014_11-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFApfelbaum2014" class="citation book cs1">Apfelbaum J (8 September 2014). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=IlTOAwAAQBAJ&pg=PT190"><i>Ambulatory Anesthesia, An Issue of Anesthesiology Clinics</i></a>. Elsevier Health Sciences. pp. 190–. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-323-29934-3" title="Special:BookSources/978-0-323-29934-3"><bdi>978-0-323-29934-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Ambulatory+Anesthesia%2C+An+Issue+of+Anesthesiology+Clinics&rft.pages=190-&rft.pub=Elsevier+Health+Sciences&rft.date=2014-09-08&rft.isbn=978-0-323-29934-3&rft.aulast=Apfelbaum&rft.aufirst=J&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DIlTOAwAAQBAJ%26pg%3DPT190&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-CowanYosipovitch2015-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-CowanYosipovitch2015_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-CowanYosipovitch2015_12-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLeslieGreaversYosipovitch2015" class="citation book cs1">Leslie TA, Greavers MW, Yosipovitch G (10 April 2015). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=Jl0SCAAAQBAJ&pg=PA307">"Current Topical and Systemic Therapies for Itch"</a>. 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In Allerton C (ed.). <i>Pain Therapeutics: Current and Future Treatment Paradigms</i>. Royal Society of Chemistry. pp. 56–. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-84973-645-9" title="Special:BookSources/978-1-84973-645-9"><bdi>978-1-84973-645-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Oral+Opioids&rft.btitle=Pain+Therapeutics%3A+Current+and+Future+Treatment+Paradigms&rft.pages=56-&rft.pub=Royal+Society+of+Chemistry&rft.date=2013&rft.isbn=978-1-84973-645-9&rft.aulast=Goli&rft.aufirst=V&rft.au=Pryde%2C+D&rft.au=Omoto%2C+K&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DzUINAgAAQBAJ%26pg%3DPA56&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214916">"Korsuva: FDA-Approved Drugs"</a>. <i>U.S. Food and Drug Administration</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210825050736/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214916">Archived</a> from the original on 25 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">24 August</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration&rft.atitle=Korsuva%3A+FDA-Approved+Drugs&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fcder%2Fdaf%2Findex.cfm%3Fevent%3Doverview.process%26ApplNo%3D214916&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.businesswire.com/news/home/20210823005635/en/Vifor-Pharma-and-Cara-Therapeutics-announce-U.S.-FDA-approval-of-KORSUVA%E2%84%A2-injection-for-the-treatment-of-moderate-to-severe-pruritus-in-hemodialysis-patients">"Vifor Pharma and Cara Therapeutics announce U.S. FDA approval of Korsuva injection for the treatment of moderate-to-severe pruritus in hemodialysis patients"</a> (Press release). Vifor Pharma. 24 August 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210824213538/https://www.businesswire.com/news/home/20210823005635/en/Vifor-Pharma-and-Cara-Therapeutics-announce-U.S.-FDA-approval-of-KORSUVA%E2%84%A2-injection-for-the-treatment-of-moderate-to-severe-pruritus-in-hemodialysis-patients">Archived</a> from the original on 24 August 2021<span class="reference-accessdate">. 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Retrieved <span class="nowrap">22 January</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=report&rft.btitle=Advancing+Health+Through+Innovation%3A+New+Drug+Therapy+Approvals+2021&rft.date=2022-05-13&rft_id=https%3A%2F%2Fwww.fda.gov%2Fmedia%2F155227%2Fdownload&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-Kapruvia:_Pending_EC_decision-17"><span class="mw-cite-backlink">^ <a href="#cite_ref-Kapruvia:_Pending_EC_decision_17-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Kapruvia:_Pending_EC_decision_17-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20221027142342/https://www.ema.europa.eu/en/medicines/human/EPAR/kapruvia">"Kapruvia: Pending EC decision"</a>. <i>European Medicines Agency</i>. 24 February 2022. Archived from <a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/summaries-opinion/kapruvia">the original</a> on 27 October 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">26 February</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency&rft.atitle=Kapruvia%3A+Pending+EC+decision&rft.date=2022-02-24&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2Fsummaries-opinion%2Fkapruvia&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://ec.europa.eu/health/documents/community-register/html/h1643.htm">"Kapruvia Product information"</a>. <i>Union Register of medicinal products</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230304072219/https://ec.europa.eu/health/documents/community-register/html/h1643.htm">Archived</a> from the original on 4 March 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">3 March</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Union+Register+of+medicinal+products&rft.atitle=Kapruvia+Product+information&rft_id=https%3A%2F%2Fec.europa.eu%2Fhealth%2Fdocuments%2Fcommunity-register%2Fhtml%2Fh1643.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFishbaneJamalMuneraWen2020" class="citation journal cs1">Fishbane S, Jamal A, Munera C, Wen W, Menzaghi F (January 2020). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1912770">"A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus"</a>. <i>The New England Journal of Medicine</i>. <b>382</b> (3): 222–232. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1912770">10.1056/NEJMoa1912770</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31702883">31702883</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=A+Phase+3+Trial+of+Difelikefalin+in+Hemodialysis+Patients+with+Pruritus&rft.volume=382&rft.issue=3&rft.pages=222-232&rft.date=2020-01&rft_id=info%3Adoi%2F10.1056%2FNEJMoa1912770&rft_id=info%3Apmid%2F31702883&rft.aulast=Fishbane&rft.aufirst=S&rft.au=Jamal%2C+A&rft.au=Munera%2C+C&rft.au=Wen%2C+W&rft.au=Menzaghi%2C+F&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJMoa1912770&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADifelikefalin" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Difelikefalin&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT03422653">NCT03422653</a></i> for "A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li> <li>Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/show/NCT03636269">NCT03636269</a></i> for "CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-2)" at <a href="/wiki/ClinicalTrials.gov" title="ClinicalTrials.gov">ClinicalTrials.gov</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Analgesics" title="Template:Analgesics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Analgesics" title="Template talk:Analgesics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Analgesics" title="Special:EditPage/Template:Analgesics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Analgesics_(N02A,_N02B)" style="font-size:114%;margin:0 4em"><a href="/wiki/Analgesic" title="Analgesic">Analgesics</a> (<a href="/wiki/ATC_code_N02#N02A" title="ATC code N02">N02A</a>, <a href="/wiki/ATC_code_N02#N02B" title="ATC code N02">N02B</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opioid" title="Opioid">Opioids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opiate" title="Opiate">Opiates</a>/<a href="/wiki/Opium" title="Opium">opium</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Codeine" title="Codeine">Codeine</a><sup>#</sup> <ul><li><a href="/wiki/Codeine/aspirin" class="mw-redirect" title="Codeine/aspirin">+aspirin</a></li> <li><a href="/wiki/Codeine/paracetamol" title="Codeine/paracetamol">+paracetamol</a></li></ul></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a><sup>#</sup> (<a href="/wiki/Morphine/naltrexone" title="Morphine/naltrexone">+naltrexone</a>)</li> <li><a href="/wiki/Opium" title="Opium">Opium</a></li> <li><a href="/wiki/Laudanum" title="Laudanum">Laudanum</a></li> <li><a href="/wiki/Paregoric" title="Paregoric">Paregoric</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Semisynthetic</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a><span class="nowrap"> </span>(<a href="/wiki/Buprenorphine/naloxone" title="Buprenorphine/naloxone">+naloxone</a>)</li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a><span class="nowrap"> </span>(<a href="/wiki/Co-dydramol" title="Co-dydramol">+paracetamol</a>)</li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a><span class="nowrap"> </span>(<a href="/wiki/Hydrocodone/paracetamol" title="Hydrocodone/paracetamol">+paracetamol</a>, <a href="/wiki/Hydrocodone/ibuprofen" title="Hydrocodone/ibuprofen">+ibuprofen</a>, <a href="/wiki/Hydrocodone/aspirin" title="Hydrocodone/aspirin">+aspirin</a>)</li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a><span class="nowrap"> </span>(<a href="/wiki/Oxycodone/paracetamol" title="Oxycodone/paracetamol">+paracetamol</a>, <a href="/wiki/Oxycodone/aspirin" title="Oxycodone/aspirin">+aspirin</a>, <a href="/wiki/Oxycodone/ibuprofen" title="Oxycodone/ibuprofen">+ibuprofen</a>, <a href="/wiki/Oxycodone/naloxone" title="Oxycodone/naloxone">+naloxone</a>, <a href="/w/index.php?title=Oxycodone/naltrexone&action=edit&redlink=1" class="new" title="Oxycodone/naltrexone (page does not exist)">+naltrexone</a>)</li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Papaveretum" title="Papaveretum">Papaveretum</a></li> <li><a href="/wiki/Thebacon" title="Thebacon">Thebacon</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Synthetic</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Prodine" title="Prodine">Alphaprodine</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Ethoheptazine" title="Ethoheptazine">Ethoheptazine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a><sup>#</sup> (<a href="/wiki/Fentanyl/fluanisone" title="Fentanyl/fluanisone">+fluanisone</a>)</li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a><sup>#</sup></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Norpipanone" title="Norpipanone">Norpipanone</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenadoxone" title="Phenadoxone">Phenadoxone</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phenoperidine" title="Phenoperidine">Phenoperidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/wiki/Proheptazine" title="Proheptazine">Proheptazine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a><span class="nowrap"> </span>(<a href="/wiki/Celecoxib/tramadol" title="Celecoxib/tramadol">+celecoxib</a>, <a href="/wiki/Tramadol/paracetamol" title="Tramadol/paracetamol">+paracetamol</a>)</li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol</a>-type</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetanilide" title="Acetanilide">Acetanilide</a><sup>‡</sup></li> <li><a href="/wiki/Bucetin" title="Bucetin">Bucetin</a><sup>‡</sup></li> <li><a href="/w/index.php?title=Butacetin&action=edit&redlink=1" class="new" title="Butacetin (page does not exist)">Butacetin</a><sup>‡</sup></li> <li><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol (acetaminophen)</a><sup>#</sup> <ul><li><a href="/wiki/Aspirin/paracetamol/caffeine" title="Aspirin/paracetamol/caffeine">+aspirin/caffeine</a></li> <li><a href="/wiki/Codeine/paracetamol" title="Codeine/paracetamol">+codeine</a></li> <li><a href="/wiki/Hydrocodone/paracetamol" title="Hydrocodone/paracetamol">+hydrocodone</a></li> <li><a href="/wiki/Ibuprofen/paracetamol" title="Ibuprofen/paracetamol">+ibuprofen</a></li> <li><a href="/wiki/Paracetamol/metoclopramide" title="Paracetamol/metoclopramide">+metoclopramide</a></li> <li><a href="/wiki/Oxycodone/paracetamol" title="Oxycodone/paracetamol">+oxycodone</a></li> <li><a href="/wiki/Propyphenazone/paracetamol/caffeine" title="Propyphenazone/paracetamol/caffeine">+propyphenazone/caffeine</a></li> <li><a href="/wiki/Tramadol/paracetamol" title="Tramadol/paracetamol">+tramadol</a></li></ul></li> <li><a href="/w/index.php?title=Parapropamol&action=edit&redlink=1" class="new" title="Parapropamol (page does not exist)">Parapropamol</a><sup>‡</sup></li> <li><a href="/wiki/Phenacetin" title="Phenacetin">Phenacetin</a><sup>‡</sup></li> <li><a href="/wiki/Propacetamol" title="Propacetamol">Propacetamol</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nonsteroidal_anti-inflammatory_drug" title="Nonsteroidal anti-inflammatory drug">NSAIDs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Propionates</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benoxaprofen" title="Benoxaprofen">Benoxaprofen</a> <sup>‡</sup></li> <li><a href="/wiki/Fenoprofen" title="Fenoprofen">Fenoprofen</a></li> <li><a href="/wiki/Flurbiprofen" title="Flurbiprofen">Flurbiprofen</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a><sup>#</sup><span class="nowrap"> </span>(<a href="/wiki/Dexibuprofen" title="Dexibuprofen">Dexibuprofen</a>)<span class="nowrap"> </span>(<a href="/wiki/Ibuprofen/paracetamol" title="Ibuprofen/paracetamol">+paracetamol</a>)</li> <li><a href="/wiki/Ketoprofen" title="Ketoprofen">Ketoprofen</a><span class="nowrap"> </span>(<a href="/wiki/Dexketoprofen" title="Dexketoprofen">Dexketoprofen</a>)</li> <li><a href="/wiki/Loxoprofen" title="Loxoprofen">Loxoprofen</a></li> <li><a href="/wiki/Naproxen" title="Naproxen">Naproxen</a></li> <li><a href="/wiki/Oxaprozin" title="Oxaprozin">Oxaprozin</a></li> <li><a href="/wiki/Suprofen" title="Suprofen">Suprofen</a></li> <li><a href="/wiki/Tiaprofenic_acid" title="Tiaprofenic acid">Tiaprofenic acid</a></li> <li><a href="/wiki/Zaltoprofen" title="Zaltoprofen">Zaltoprofen</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Oxicams</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Isoxicam" title="Isoxicam">Isoxicam</a></li> <li><a href="/wiki/Lornoxicam" title="Lornoxicam">Lornoxicam</a></li> <li><a href="/wiki/Meloxicam" title="Meloxicam">Meloxicam</a></li> <li><a href="/wiki/Piroxicam" title="Piroxicam">Piroxicam</a></li> <li><a href="/wiki/Tenoxicam" title="Tenoxicam">Tenoxicam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Acetates</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acemetacin" title="Acemetacin">Acemetacin</a></li> <li><a href="/wiki/Bromfenac" title="Bromfenac">Bromfenac</a></li> <li><a href="/wiki/Diclofenac" title="Diclofenac">Diclofenac</a></li> <li><a href="/wiki/Etodolac" title="Etodolac">Etodolac</a></li> <li><a href="/wiki/Indometacin" title="Indometacin">Indometacin</a><span class="nowrap"> </span>(<a href="/wiki/Indometacin_farnesil" title="Indometacin farnesil">Indometacin farnesil</a>)</li> <li><a href="/wiki/Ketorolac" title="Ketorolac">Ketorolac</a></li> <li><a href="/wiki/Sulindac" title="Sulindac">Sulindac</a></li> <li><a href="/wiki/Tolmetin" title="Tolmetin">Tolmetin</a></li> <li><a href="/wiki/Zomepirac" title="Zomepirac">Zomepirac</a> <sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/COX-2_inhibitor" class="mw-redirect" title="COX-2 inhibitor">COX-2 inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Celecoxib" title="Celecoxib">Celecoxib</a><span class="nowrap"> </span>(<a href="/wiki/Celecoxib/tramadol" title="Celecoxib/tramadol">+tramadol</a>)</li> <li><a href="/wiki/Etoricoxib" title="Etoricoxib">Etoricoxib</a></li> <li><a href="/wiki/Lumiracoxib" title="Lumiracoxib">Lumiracoxib</a> <sup>‡</sup></li> <li><a href="/wiki/Parecoxib" title="Parecoxib">Parecoxib</a></li> <li><a href="/wiki/Rofecoxib" title="Rofecoxib">Rofecoxib</a> <sup>‡</sup></li> <li><a href="/wiki/Valdecoxib" title="Valdecoxib">Valdecoxib</a> <sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fenamic_acid" title="Fenamic acid">Fenamates</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Salicylic_acid" title="Salicylic acid">Salicylates</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aspirin" title="Aspirin">Aspirin (acetylsalicylic acid)</a><sup>#</sup> (<a href="/wiki/Aspirin/paracetamol/caffeine" title="Aspirin/paracetamol/caffeine">+paracetamol/caffeine</a>)</li> <li><a href="/wiki/Aloxiprin" title="Aloxiprin">Aloxiprin</a></li> <li><a href="/wiki/Benorilate" title="Benorilate">Benorylate</a></li> <li><a href="/wiki/Carbasalate_calcium" title="Carbasalate calcium">Carbasalate calcium</a></li> <li><a href="/wiki/Choline_salicylate" class="mw-redirect" title="Choline salicylate">Choline salicylate</a></li> <li><a href="/wiki/Diflunisal" title="Diflunisal">Diflunisal</a></li> <li><a href="/wiki/Dipyrocetyl" title="Dipyrocetyl">Dipyrocetyl</a></li> <li><a href="/wiki/Ethenzamide" title="Ethenzamide">Ethenzamide</a></li> <li><a href="/wiki/Guacetisal" title="Guacetisal">Guacetisal</a></li> <li><a href="/wiki/Imidazole_salicylate" title="Imidazole salicylate">Imidazole salicylate</a></li> <li><a href="/wiki/Magnesium_salicylate" title="Magnesium salicylate">Magnesium salicylate</a></li> <li><a href="/wiki/Morpholine_salicylate" title="Morpholine salicylate">Morpholine salicylate</a></li> <li><a href="/wiki/Potassium_salicylate" title="Potassium salicylate">Potassium salicylate</a></li> <li><a href="/wiki/Salicin" title="Salicin">Salicin</a></li> <li><a href="/wiki/Salicylamide" title="Salicylamide">Salicylamide</a></li> <li><a href="/wiki/Salsalate" title="Salsalate">Salsalate</a></li> <li><a href="/wiki/Sodium_salicylate" title="Sodium salicylate">Sodium salicylate</a></li> <li><a href="/wiki/Wintergreen" title="Wintergreen">Wintergreen</a><span class="nowrap"> </span>(<a href="/wiki/Methyl_salicylate" title="Methyl salicylate">methyl salicylate</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyrazolone" title="Pyrazolone">Pyrazolones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminophenazone" title="Aminophenazone">Aminophenazone</a><sup>‡</sup></li> <li><a href="/wiki/Ampyrone" title="Ampyrone">Ampyrone</a></li> <li><a href="/wiki/Metamizole" title="Metamizole">Metamizole (dipyrone)</a></li> <li><a href="/wiki/Nifenazone" title="Nifenazone">Nifenazone</a></li> <li><a href="/wiki/Phenazone" title="Phenazone">Phenazone</a></li> <li><a href="/wiki/Propyphenazone" title="Propyphenazone">Propyphenazone</a><span class="nowrap"> </span>(<a href="/wiki/Propyphenazone/paracetamol/caffeine" title="Propyphenazone/paracetamol/caffeine">+paracetamol/caffeine</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzydamine" title="Benzydamine">Benzydamine</a></li> <li><a href="/wiki/Floctafenine" title="Floctafenine">Floctafenine</a></li> <li><a href="/wiki/Glafenine" title="Glafenine">Glafenine</a></li> <li><a href="/wiki/Nabumetone" title="Nabumetone">Nabumetone</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Proquazone" title="Proquazone">Proquazone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cannabinoid" title="Cannabinoid">Cannabinoids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Cannabis_(drug)" title="Cannabis (drug)">Cannabis</a></li> <li><a href="/wiki/Nabilone" title="Nabilone">Nabilone</a></li> <li><a href="/wiki/Nabiximols" title="Nabiximols">Nabiximols</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">Tetrahydrocannabinol (dronabinol)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Channel_modulator" title="Channel modulator">Ion channel<br />modulators</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Calcium blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Alcohol (ethanol)</a></li> <li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Leconotide" title="Leconotide">Leconotide</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li> <li><a href="/wiki/Ziconotide" title="Ziconotide">Ziconotide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Sodium blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Lacosamide" title="Lacosamide">Lacosamide</a></li> <li><a href="/wiki/Local_anesthetic" title="Local anesthetic">Local anesthetics</a> (e.g., <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>, <a href="/wiki/Lidocaine" title="Lidocaine">lidocaine</a>)</li> <li><a href="/wiki/Mexiletine" title="Mexiletine">Mexiletine</a></li> <li><a href="/wiki/Nefopam" title="Nefopam">Nefopam</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a><sup>#</sup>)</li></ul> <ul><li><i>Na<sub>v</sub>1.7/1.8-selective:</i> <a href="/wiki/DSP-2230" title="DSP-2230">DSP-2230</a><sup>§</sup></li> <li><a href="/wiki/Funapide" title="Funapide">Funapide</a><sup>§</sup></li> <li><a href="/wiki/PF-05089771" title="PF-05089771">PF-05089771</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Potassium openers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a><sup>‡</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Muscle_relaxant" title="Muscle relaxant">Myorelaxants</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/wiki/Chlorzoxazone" title="Chlorzoxazone">Chlorzoxazone</a></li> <li><a href="/wiki/Cyclobenzaprine" title="Cyclobenzaprine">Cyclobenzaprine</a></li> <li><a href="/wiki/Mephenoxalone" title="Mephenoxalone">Mephenoxalone</a></li> <li><a href="/wiki/Methocarbamol" title="Methocarbamol">Methocarbamol</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Analgecine" title="Analgecine">Analgecine</a></li> <li><a href="/wiki/Analgesic_adjuvant" title="Analgesic adjuvant">Analgesic adjuvant</a></li> <li><a href="/wiki/Bedinvetmab" title="Bedinvetmab">Bedinvetmab</a></li> <li><a href="/wiki/Camphor" title="Camphor">Camphor</a></li> <li><a href="/wiki/Capsaicin" title="Capsaicin">Capsaicin</a></li> <li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Methoxyflurane" title="Methoxyflurane">Methoxyflurane</a></li> <li><a href="/wiki/Phenazopyridine" title="Phenazopyridine">Phenazopyridine</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Rimazolium" title="Rimazolium">Rimazolium</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Antipruritics_(D04)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Antipruritics" title="Template:Antipruritics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Antipruritics" title="Template talk:Antipruritics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Antipruritics" title="Special:EditPage/Template:Antipruritics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Antipruritics_(D04)" style="font-size:114%;margin:0 4em"><a href="/wiki/Antipruritic" title="Antipruritic">Antipruritics</a> (<a href="/wiki/ATC_code_D04" title="ATC code D04">D04</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: Linen"><a href="/wiki/Histamine_antagonist" class="mw-redirect" title="Histamine antagonist">Antihistamines</a> for <a href="/wiki/Topical" class="mw-redirect" title="Topical">topical</a> use</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bamipine" title="Bamipine">Bamipine</a></li> <li><a href="/wiki/Chloropyramine" title="Chloropyramine">Chloropyramine</a></li> <li><a href="/wiki/Chlorphenoxamine" title="Chlorphenoxamine">Chlorphenoxamine</a></li> <li><a href="/wiki/Clemastine" title="Clemastine">Clemastine</a></li> <li><a href="/wiki/Dimetindene" title="Dimetindene">Dimetindene</a></li> <li><a href="/wiki/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a></li> <li><a href="/wiki/Isothipendyl" title="Isothipendyl">Isothipendyl</a></li> <li><a href="/wiki/Mepyramine" title="Mepyramine">Mepyramine</a></li> <li><a href="/wiki/Pheniramine" title="Pheniramine">Pheniramine</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Thenalidine" title="Thenalidine">Thenalidine</a></li> <li><a href="/wiki/Thonzylamine" title="Thonzylamine">Thonzylamine</a></li> <li><a href="/wiki/Tolpropamine" title="Tolpropamine">Tolpropamine</a></li> <li><a href="/wiki/Tripelennamine" title="Tripelennamine">Tripelennamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: Linen"><a href="/wiki/Anesthetic" title="Anesthetic">Anesthetics</a> for topical use</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzocaine" title="Benzocaine">Benzocaine</a></li> <li><a href="/wiki/Cinchocaine" title="Cinchocaine">Cinchocaine</a></li> <li><a href="/wiki/Dibucaine" class="mw-redirect" title="Dibucaine">Dibucaine</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Oxybuprocaine" title="Oxybuprocaine">Oxybuprocaine</a></li> <li><a href="/wiki/Pramocaine" title="Pramocaine">Pramocaine</a></li> <li><a href="/wiki/Quinisocaine" title="Quinisocaine">Quinisocaine</a></li> <li><a href="/wiki/Tetracaine" title="Tetracaine">Tetracaine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: Linen">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Corticosteroid" title="Corticosteroid">Corticosteroids</a> (e.g., <a href="/wiki/Hydrocortisone" title="Hydrocortisone">hydrocortisone</a>)</li> <li><a href="/wiki/Counterirritant" title="Counterirritant">Counterirritants</a> (e.g., <a href="/wiki/Mentha" title="Mentha">mint oil</a>, <a href="/wiki/Menthol" title="Menthol">menthol</a>, <a href="/wiki/Camphor" title="Camphor">camphor</a>)</li> <li><a class="mw-selflink selflink">Difelikefalin</a></li> <li><a href="/wiki/Doxepin" title="Doxepin">Doxepin</a></li> <li><a href="/wiki/Nalfurafine" title="Nalfurafine">Nalfurafine</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Opioid_receptor_modulators" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Opioid_receptor_modulators" title="Template:Opioid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Opioid_receptor_modulators" title="Template talk:Opioid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Opioid_receptor_modulators" title="Special:EditPage/Template:Opioid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Opioid_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-opioid</a><br />(MOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Agonists(abridged;_full_list)" scope="row" class="navbox-group" style="width:1%">Agonists<br />(abridged;<br /> <a href="/wiki/List_of_opioids" title="List of opioids">full list</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-HO-PCP" title="3-HO-PCP">3-HO-PCP</a></li> <li><a href="/w/index.php?title=7-Acetoxymitragynine&action=edit&redlink=1" class="new" title="7-Acetoxymitragynine (page does not exist)">7-Acetoxymitragynine</a></li> <li><a href="/wiki/7-Hydroxymitragynine" title="7-Hydroxymitragynine">7-Hydroxymitragynine</a></li> <li><a href="/w/index.php?title=%CE%A8-Akuammigine&action=edit&redlink=1" class="new" title="Ψ-Akuammigine (page does not exist)">ψ-Akuammigine</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">α-Chlornaltrexamine</a></li> <li><a href="/w/index.php?title=Alpha-Narcotine&action=edit&redlink=1" class="new" title="Alpha-Narcotine (page does not exist)">α-Narcotine</a></li> <li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Acetylfentanyl" title="Acetylfentanyl">Acetylfentanyl</a></li> <li><a href="/wiki/Acrylfentanyl" title="Acrylfentanyl">Acrylfentanyl</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/AH-7921" title="AH-7921">AH-7921</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/w/index.php?title=Akuammidine&action=edit&redlink=1" class="new" title="Akuammidine (page does not exist)">Akuammidine</a></li> <li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Apparicine" title="Apparicine">Apparicine</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Benzhydrocodone" title="Benzhydrocodone">Benzhydrocodone</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Butyrfentanyl" title="Butyrfentanyl">Butyrfentanyl</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Chloroxymorphamine" title="Chloroxymorphamine">Chloroxymorphamine</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/DAMGO" title="DAMGO">DAMGO (DAGO)</a></li> <li><a href="/wiki/Dermorphin" title="Dermorphin">Dermorphin</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene (propoxyphene)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dimethylaminopivalophenone" title="Dimethylaminopivalophenone">Dimethylaminopivalophenone</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diphenoxylate" title="Diphenoxylate">Diphenoxylate</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/Endomorphin-1" title="Endomorphin-1">Endomorphin-1</a></li> <li><a href="/wiki/Endomorphin-2" title="Endomorphin-2">Endomorphin-2</a></li> <li><a href="/wiki/Eseroline" title="Eseroline">Eseroline</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Frakefamide" title="Frakefamide">Frakefamide</a></li> <li><a href="/wiki/Furanylfentanyl" title="Furanylfentanyl">Furanylfentanyl</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/Hodgkinsine" title="Hodgkinsine">Hodgkinsine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/IBNtxA" title="IBNtxA">IBNtxA</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levacetylmethadol" title="Levacetylmethadol">Levacetylmethadol</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Loxicodegol" class="mw-redirect" title="Loxicodegol">Loxicodegol</a></li> <li><a href="/wiki/LS-115509" title="LS-115509">LS-115509</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphiceptin" title="Morphiceptin">Morphiceptin</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalmexone" title="Nalmexone">Nalmexone</a></li> <li><a href="/wiki/Naltalimide" title="Naltalimide">Naltalimide</a></li> <li><a href="/w/index.php?title=Neopine&action=edit&redlink=1" class="new" title="Neopine (page does not exist)">Neopine</a></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Nufenoxole" title="Nufenoxole">Nufenoxole</a></li> <li><a href="/wiki/Octreotide" title="Octreotide">Octreotide</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Oxycodegol" title="Oxycodegol">Oxycodegol</a></li> <li><a href="/wiki/Oxymorphone-3-methoxynaltrexonazine" title="Oxymorphone-3-methoxynaltrexonazine">OM-3-MNZ</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphazone" title="Oxymorphazone">Oxymorphazone</a></li> <li><a href="/w/index.php?title=Oxymorphonazine&action=edit&redlink=1" class="new" title="Oxymorphonazine (page does not exist)">Oxymorphonazine</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/w/index.php?title=Oxymorphone_phenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone phenylhydrazone (page does not exist)">Oxymorphone phenylhydrazone</a></li> <li><a href="/w/index.php?title=Oxymorphone_p-nitrophenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone p-nitrophenylhydrazone (page does not exist)">OxyPNPH</a></li> <li><i><a href="/wiki/Papaver_somniferum" title="Papaver somniferum">Papaver somniferum</a></i> (<a href="/wiki/Opium" title="Opium">opium</a>)</li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pericine" title="Pericine">Pericine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/w/index.php?title=PL-017&action=edit&redlink=1" class="new" title="PL-017 (page does not exist)">PL-017</a></li> <li><a href="/wiki/Prodine" title="Prodine">Prodine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/PZM21" title="PZM21">PZM21</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Salsolinol" title="Salsolinol">Salsolinol</a></li> <li><a href="/wiki/SC-17599" title="SC-17599">SC-17599</a></li> <li><a href="/wiki/Sinomenine" title="Sinomenine">Sinomenine</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tetrahydropapaveroline" title="Tetrahydropapaveroline">Tetrahydropapaveroline</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tianeptine" title="Tianeptine">Tianeptine</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/wiki/Trimebutine" title="Trimebutine">Trimebutine</a></li> <li><a href="/wiki/TRIMU_5" title="TRIMU 5">TRIMU 5</a></li> <li><a href="/wiki/TRV734" title="TRV734">TRV734</a></li> <li><a href="/w/index.php?title=Tubotaiwine&action=edit&redlink=1" class="new" title="Tubotaiwine (page does not exist)">Tubotaiwine</a></li> <li><a href="/wiki/U-47700" title="U-47700">U-47700</a></li> <li><a href="/wiki/Valorphin" title="Valorphin">Valorphin</a></li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Picenadol" title="Picenadol">(3S,4S)-Picenadol</a></li> <li><a href="/wiki/Viminol" title="Viminol">2-(S)-N,N-(R)-Viminol</a></li> <li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/4-Caffeoyl-1,5-quinide" title="4-Caffeoyl-1,5-quinide">4-Caffeoyl-1,5-quinide</a></li> <li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/Alpha-Gliadin" class="mw-redirect" title="Alpha-Gliadin">α-Gliadin</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Akuammine" title="Akuammine">Akuammine</a></li> <li><a href="/wiki/Alvimopan" title="Alvimopan">Alvimopan</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li>CTAP</li> <li><a href="/w/index.php?title=CTOP&action=edit&redlink=1" class="new" title="CTOP (page does not exist)">CTOP</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Cyprodime" title="Cyprodime">Cyprodime</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/w/index.php?title=Ginsenoside_R&action=edit&redlink=1" class="new" title="Ginsenoside R (page does not exist)">Ginsenoside R</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Lobeline" title="Lobeline">Lobeline</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methocinnamox" title="Methocinnamox">Methocinnamox</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylsamidorphan_chloride&action=edit&redlink=1" class="new" title="Methylsamidorphan chloride (page does not exist)">Methylsamidorphan chloride</a></li> <li><a href="/wiki/Naldemedine" title="Naldemedine">Naldemedine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Nalorphine_dinicotinate" title="Nalorphine dinicotinate">Nalorphine dinicotinate</a></li> <li><a href="/wiki/Naloxazone" title="Naloxazone">Naloxazone</a></li> <li><a href="/wiki/Naloxegol" title="Naloxegol">Naloxegol</a></li> <li><a href="/wiki/Naloxol" title="Naloxol">Naloxol</a></li> <li><a href="/wiki/Naloxonazine" title="Naloxonazine">Naloxonazine</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/w/index.php?title=Naltrexazone&action=edit&redlink=1" class="new" title="Naltrexazone (page does not exist)">Naltrexazone</a></li> <li><a href="/w/index.php?title=Naltrexonazine&action=edit&redlink=1" class="new" title="Naltrexonazine (page does not exist)">Naltrexonazine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid</a><br />(DOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/7-Spiroindanyloxymorphone" title="7-Spiroindanyloxymorphone">7-SIOM</a></li> <li><a href="/wiki/ADL-5747" title="ADL-5747">ADL-5747 (PF-04856881)</a></li> <li><a href="/wiki/ADL-5859" title="ADL-5859">ADL-5859</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/ARM390" title="ARM390">AR-M100390 (ARM390)</a></li> <li><a href="/wiki/AZD2327" class="mw-redirect" title="AZD2327">AZD2327</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/wiki/BU-48" title="BU-48">BU-48</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/Deltorphin" title="Deltorphin">Deltorphin A</a></li> <li><a href="/wiki/Deltorphin_I" title="Deltorphin I">Deltorphin I</a></li> <li><a href="/w/index.php?title=Deltorphin_II&action=edit&redlink=1" class="new" title="Deltorphin II (page does not exist)">Deltorphin II</a></li> <li><a href="/wiki/Desmethylclozapine" title="Desmethylclozapine">Desmethylclozapine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/DPDPE" title="DPDPE">DPDPE</a></li> <li><a href="/wiki/DPI-221" title="DPI-221">DPI-221</a></li> <li><a href="/wiki/DPI-3290" title="DPI-3290">DPI-3290</a></li> <li><a href="/w/index.php?title=(D-Ser2,_Leu5,_Thr6)-Enkephalin&action=edit&redlink=1" class="new" title="(D-Ser2, Leu5, Thr6)-Enkephalin (page does not exist)">DSLET</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/w/index.php?title=Fentanyl_isothiocyanate&action=edit&redlink=1" class="new" title="Fentanyl isothiocyanate (page does not exist)">FIT</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Isomethadone" title="Isomethadone">Isomethadone</a></li> <li><a href="/wiki/JNJ-20788560" title="JNJ-20788560">JNJ-20788560</a></li> <li><a href="/wiki/KNT-127" title="KNT-127">KNT-127</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/N-Phenethyl-14-ethoxymetopon" title="N-Phenethyl-14-ethoxymetopon">N-Phenethyl-14-ethoxymetopon</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RWJ-394674" title="RWJ-394674">RWJ-394674</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/w/index.php?title=SB-235863&action=edit&redlink=1" class="new" title="SB-235863 (page does not exist)">SB-235863</a></li> <li><a href="/wiki/SNC-80" title="SNC-80">SNC-80</a></li> <li><a href="/w/index.php?title=SNC-162&action=edit&redlink=1" class="new" title="SNC-162 (page does not exist)">SNC-162</a></li> <li><a href="/wiki/TAN-67" title="TAN-67">TAN-67 (SB-205,607)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/C-8813" title="C-8813">Thiobromadol (C-8813)</a></li> <li><a href="/wiki/Tonazocine" title="Tonazocine">Tonazocine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/w/index.php?title=TRV250&action=edit&redlink=1" class="new" title="TRV250 (page does not exist)">TRV250</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li> <li><a href="/wiki/Zenazocine" title="Zenazocine">Zenazocine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/w/index.php?title=Naltrindole-5%27-isothiocyanate&action=edit&redlink=1" class="new" title="Naltrindole-5'-isothiocyanate (page does not exist)">5'-NTII</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/w/index.php?title=Alpha-Santolol&action=edit&redlink=1" class="new" title="Alpha-Santolol (page does not exist)">α-Santolol</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/w/index.php?title=7-Benzylidenenaltrexone&action=edit&redlink=1" class="new" title="7-Benzylidenenaltrexone (page does not exist)">BNTX</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/w/index.php?title=ICI-154129&action=edit&redlink=1" class="new" title="ICI-154129 (page does not exist)">ICI-154129</a></li> <li><a href="/w/index.php?title=ICI-174864&action=edit&redlink=1" class="new" title="ICI-174864 (page does not exist)">ICI-174864</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylnaltrindole&action=edit&redlink=1" class="new" title="Methylnaltrindole (page does not exist)">Methylnaltrindole</a></li> <li><a href="/w/index.php?title=N-Benzylnaltrindole&action=edit&redlink=1" class="new" title="N-Benzylnaltrindole (page does not exist)">N-Benzylnaltrindole</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/w/index.php?title=SDM25N&action=edit&redlink=1" class="new" title="SDM25N (page does not exist)">SDM25N</a></li> <li><a href="/wiki/SoRI-9409" title="SoRI-9409">SoRI-9409</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid</a><br />(KOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/8-Carboxamidocyclazocine" title="8-Carboxamidocyclazocine">8-CAC</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/14-Methoxymetopon" title="14-Methoxymetopon">14-Methoxymetopon</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Allomatrine" class="mw-redirect" title="Allomatrine">Allomatrine</a></li> <li><a href="/w/index.php?title=Apadoline&action=edit&redlink=1" class="new" title="Apadoline (page does not exist)">Apadoline</a></li> <li><a href="/wiki/Asimadoline" title="Asimadoline">Asimadoline</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Big_dynorphin" title="Big dynorphin">Big dynorphin</a></li> <li><a href="/wiki/Bremazocine" title="Bremazocine">Bremazocine</a></li> <li><a href="/wiki/BRL-52537" title="BRL-52537">BRL-52537</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Ciprefadol" title="Ciprefadol">Ciprefadol</a></li> <li><a href="/wiki/CR665" title="CR665">CR665</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/Cyclorphan" title="Cyclorphan">Cyclorphan</a></li> <li><a href="/wiki/Cyprenorphine" title="Cyprenorphine">Cyprenorphine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a class="mw-selflink selflink">Difelikefalin</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Dynorphin_B" title="Dynorphin B">Dynorphin B (rimorphin)</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Enadoline" title="Enadoline">Enadoline</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/w/index.php?title=Erinacine_E&action=edit&redlink=1" class="new" title="Erinacine E (page does not exist)">Erinacine E</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fedotozine" title="Fedotozine">Fedotozine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/wiki/GR-89696" title="GR-89696">GR-89696</a></li> <li><a href="/w/index.php?title=GR-103545&action=edit&redlink=1" class="new" title="GR-103545 (page does not exist)">GR-103545</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/HS665" title="HS665">HS665</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/HZ-2" title="HZ-2">HZ-2</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/ICI-199,441" title="ICI-199,441">ICI-199,441</a></li> <li><a href="/wiki/ICI-204,448" title="ICI-204,448">ICI-204,448</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketazocine" title="Ketazocine">Ketazocine</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leumorphin" title="Leumorphin">Leumorphin (dynorphin B-29)</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/LPK-26" title="LPK-26">LPK-26</a></li> <li><a href="/wiki/Lufuradom" title="Lufuradom">Lufuradom</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/w/index.php?title=MB-1C-OH&action=edit&redlink=1" class="new" title="MB-1C-OH (page does not exist)">MB-1C-OH</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Moxazocine" title="Moxazocine">Moxazocine</a></li> <li><a href="/w/index.php?title=MR-2034&action=edit&redlink=1" class="new" title="MR-2034 (page does not exist)">MR-2034</a></li> <li><a href="/w/index.php?title=N-MPPP&action=edit&redlink=1" class="new" title="N-MPPP (page does not exist)">N-MPPP</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalfurafine" title="Nalfurafine">Nalfurafine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Niravoline" title="Niravoline">Niravoline</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Norbuprenorphine-3-glucuronide" title="Norbuprenorphine-3-glucuronide">Norbuprenorphine-3-glucuronide</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Proxorphan" title="Proxorphan">Proxorphan</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Salvinorin_A" title="Salvinorin A">Salvinorin A</a> (<a href="/wiki/Salvia_divinorum" title="Salvia divinorum">salvia</a>)</li> <li><a href="/wiki/Salvinorin_B_ethoxymethyl_ether" class="mw-redirect" title="Salvinorin B ethoxymethyl ether">Salvinorin B ethoxymethyl ether</a></li> <li><a href="/wiki/Salvinorin_B_methoxymethyl_ether" title="Salvinorin B methoxymethyl ether">Salvinorin B methoxymethyl ether</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Spiradoline" title="Spiradoline">Spiradoline (U-62,066)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tifluadom" title="Tifluadom">Tifluadom</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Desipramine" title="Desipramine">desipramine</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/U-50488" title="U-50488">U-50488</a></li> <li><a href="/w/index.php?title=U-54,494A&action=edit&redlink=1" class="new" title="U-54,494A (page does not exist)">U-54,494A</a></li> <li><a href="/wiki/U-69,593" title="U-69,593">U-69,593</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/5%27-Guanidinonaltrindole" title="5'-Guanidinonaltrindole">5'-GNTI</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Buprenorphine/samidorphan" title="Buprenorphine/samidorphan">Buprenorphine/samidorphan</a></li> <li><a href="/wiki/Amentoflavone" title="Amentoflavone">Amentoflavone</a></li> <li><a href="/w/index.php?title=5%27-Acetamidinoethylnaltrindole&action=edit&redlink=1" class="new" title="5'-Acetamidinoethylnaltrindole (page does not exist)">ANTI</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/w/index.php?title=Arodyne&action=edit&redlink=1" class="new" title="Arodyne (page does not exist)">Arodyne</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Aticaprant" title="Aticaprant">Aticaprant</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/w/index.php?title=AZ-MTAB&action=edit&redlink=1" class="new" title="AZ-MTAB (page does not exist)">AZ-MTAB</a></li> <li><a href="/wiki/Binaltorphimine" title="Binaltorphimine">Binaltorphimine</a></li> <li><a href="/wiki/BU09059" title="BU09059">BU09059</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/CERC-501" class="mw-redirect" title="CERC-501">CERC-501 (LY-2456302)</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Icalcaprant" title="Icalcaprant">CVL-354</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/w/index.php?title=DIPPA&action=edit&redlink=1" class="new" title="DIPPA (page does not exist)">DIPPA</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/w/index.php?title=LY-2444296&action=edit&redlink=1" class="new" title="LY-2444296 (page does not exist)">LY-2444296</a></li> <li><a href="/wiki/LY-2459989" title="LY-2459989">LY-2459989</a></li> <li><a href="/w/index.php?title=LY-2795050&action=edit&redlink=1" class="new" title="LY-2795050 (page does not exist)">LY-2795050</a></li> <li><a href="/w/index.php?title=MeJDTic&action=edit&redlink=1" class="new" title="MeJDTic (page does not exist)">MeJDTic</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=ML190&action=edit&redlink=1" class="new" title="ML190 (page does not exist)">ML190</a></li> <li><a href="/w/index.php?title=ML350&action=edit&redlink=1" class="new" title="ML350 (page does not exist)">ML350</a></li> <li><a href="/w/index.php?title=MR-2266&action=edit&redlink=1" class="new" title="MR-2266 (page does not exist)">MR-2266</a></li> <li><a href="/w/index.php?title=N-Fluoropropyl-JDTic&action=edit&redlink=1" class="new" title="N-Fluoropropyl-JDTic (page does not exist)">N-Fluoropropyl-JDTic</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Navacaprant" title="Navacaprant">Navacaprant</a></li> <li><a href="/wiki/Norbinaltorphimine" title="Norbinaltorphimine">Norbinaltorphimine</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/PF-4455242" class="mw-redirect" title="PF-4455242">PF-4455242</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/w/index.php?title=UPHIT&action=edit&redlink=1" class="new" title="UPHIT (page does not exist)">UPHIT</a></li> <li><a href="/wiki/Zyklophin" title="Zyklophin">Zyklophin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a><br />(NOP)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Arg14,Lys15)Nociceptin&action=edit&redlink=1" class="new" title="(Arg14,Lys15)Nociceptin (page does not exist)">(Arg14,Lys15)Nociceptin</a></li> <li><a href="/w/index.php?title=((pF)Phe4)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="((pF)Phe4)Nociceptin(1-13)NH2 (page does not exist)">((pF)Phe<sup>4</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=(Phe1%CE%A8(CH2-NH)Gly2)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2 (page does not exist)">(Phe<sup>1</sup>Ψ(CH<sub>2</sub>-NH)Gly<sup>2</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRWK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRWK-NH2 (page does not exist)">Ac-RYYRWK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRIK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRIK-NH2 (page does not exist)">Ac-RYYRIK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/w/index.php?title=JNJ-19385899&action=edit&redlink=1" class="new" title="JNJ-19385899 (page does not exist)">JNJ-19385899</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/MCOPPB" title="MCOPPB">MCOPPB</a></li> <li><a href="/wiki/MT-7716" title="MT-7716">MT-7716</a></li> <li><a href="/wiki/NNC_63-0532" title="NNC 63-0532">NNC 63-0532</a></li> <li><a href="/wiki/Nociceptin" title="Nociceptin">Nociceptin (orphanin FQ)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-11)&action=edit&redlink=1" class="new" title="Nociceptin (1-11) (page does not exist)">Nociceptin (1-11)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-13)NH2&action=edit&redlink=1" class="new" title="Nociceptin (1-13)NH2 (page does not exist)">Nociceptin (1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Ro64-6198" title="Ro64-6198">Ro64-6198</a></li> <li><a href="/wiki/Ro65-6570" title="Ro65-6570">Ro65-6570</a></li> <li><a href="/wiki/SCH-221510" title="SCH-221510">SCH-221510</a></li> <li><a href="/w/index.php?title=SCH-486757&action=edit&redlink=1" class="new" title="SCH-486757 (page does not exist)">SCH-486757</a></li> <li><a href="/w/index.php?title=SR-8993&action=edit&redlink=1" class="new" title="SR-8993 (page does not exist)">SR-8993</a></li> <li><a href="/wiki/SR-16435" title="SR-16435">SR-16435</a></li> <li><a href="/wiki/Sunobinop" title="Sunobinop">Sunobinop (S-117957)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Nphe1)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Nphe1)Nociceptin(1-13)NH2 (page does not exist)">(Nphe<sup>1</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/w/index.php?title=BAN-ORL-24&action=edit&redlink=1" class="new" title="BAN-ORL-24 (page does not exist)">BAN-ORL-24</a></li> <li><a href="/wiki/BTRX-246040" title="BTRX-246040">BTRX-246040 (LY-2940094)</a></li> <li><a href="/wiki/J-113,397" title="J-113,397">J-113,397</a></li> <li><a href="/wiki/JTC-801" title="JTC-801">JTC-801</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-7)&action=edit&redlink=1" class="new" title="Nociceptin (1-7) (page does not exist)">Nociceptin (1-7)</a></li> <li><a href="/w/index.php?title=Nocistatin&action=edit&redlink=1" class="new" title="Nocistatin (page does not exist)">Nocistatin</a></li> <li><a href="/wiki/SB-612,111" title="SB-612,111">SB-612,111</a></li> <li><a href="/w/index.php?title=SR-16430&action=edit&redlink=1" class="new" title="SR-16430 (page does not exist)">SR-16430</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/w/index.php?title=Trap-101&action=edit&redlink=1" class="new" title="Trap-101 (page does not exist)">Trap-101</a></li> <li><a href="/w/index.php?title=UFP-101&action=edit&redlink=1" class="new" title="UFP-101 (page does not exist)">UFP-101</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Enkephalinase_inhibitor" title="Enkephalinase inhibitor">Enkephalinase inhibitors</a>:</i> <a href="/wiki/Amastatin" title="Amastatin">Amastatin</a></li> <li><a href="/w/index.php?title=BL-2401&action=edit&redlink=1" class="new" title="BL-2401 (page does not exist)">BL-2401</a></li> <li><a href="/wiki/Candoxatril" title="Candoxatril">Candoxatril</a></li> <li><a href="/wiki/Phenylalanine#D-,_L-_and_DL-phenylalanine" title="Phenylalanine"><span style="font-size:85%;">D </span>-Phenylalanine</a></li> <li><a href="/w/index.php?title=Dexecadotril&action=edit&redlink=1" class="new" title="Dexecadotril (page does not exist)">Dexecadotril (retorphan)</a></li> <li><a href="/wiki/Ecadotril" title="Ecadotril">Ecadotril (sinorphan)</a></li> <li><a href="/wiki/Kelatorphan" title="Kelatorphan">Kelatorphan</a></li> <li><a href="/wiki/Racecadotril" title="Racecadotril">Racecadotril (acetorphan)</a></li> <li><a href="/wiki/RB-101" title="RB-101">RB-101</a></li> <li><a href="/wiki/RB-120" title="RB-120">RB-120</a></li> <li><a href="/wiki/RB-3007" title="RB-3007">RB-3007</a></li> <li><a href="/w/index.php?title=Opiorphan&action=edit&redlink=1" class="new" title="Opiorphan (page does not exist)">Opiorphan</a></li> <li><a href="/wiki/Selank" title="Selank">Selank</a></li> <li><a href="/wiki/Semax" title="Semax">Semax</a></li> <li><a href="/wiki/Spinorphin" title="Spinorphin">Spinorphin</a></li> <li><a href="/wiki/Thiorphan" title="Thiorphan">Thiorphan</a></li> <li><a href="/wiki/Tynorphin" title="Tynorphin">Tynorphin</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> <ul><li><i>Propeptides:</i> <a href="/wiki/Lipotropin" title="Lipotropin">β-Lipotropin (proendorphin)</a></li> <li><a href="/wiki/Prodynorphin" title="Prodynorphin">Prodynorphin</a></li> <li><a href="/wiki/Proenkephalin" title="Proenkephalin">Proenkephalin</a></li> <li><a href="/w/index.php?title=Pronociceptin&action=edit&redlink=1" class="new" title="Pronociceptin (page does not exist)">Pronociceptin</a></li> <li><a href="/wiki/Proopiomelanocortin" title="Proopiomelanocortin">Proopiomelanocortin (POMC)</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Kyotorphin" title="Kyotorphin">Kyotorphin</a> (met-enkephalin releaser/degradation stabilizer)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Other_therapeutic_products_(V03AG–V03AZ)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Other_therapeutic_products" title="Template:Other therapeutic products"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Other_therapeutic_products" title="Template talk:Other therapeutic products"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Other_therapeutic_products" title="Special:EditPage/Template:Other therapeutic products"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Other_therapeutic_products_(V03AG–V03AZ)" style="font-size:114%;margin:0 4em">Other therapeutic products (<a href="/wiki/ATC_code_V03#V03AG" title="ATC code V03">V03AG</a>–<a href="/wiki/ATC_code_V03#V03AZ" title="ATC code V03">V03AZ</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Treatment of <a href="/wiki/Hypercalcemia" class="mw-redirect" title="Hypercalcemia">hypercalcemia</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium_cellulose_phosphate" title="Sodium cellulose phosphate">Sodium cellulose phosphate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Treatment of <a href="/wiki/Hypoglycaemia" class="mw-redirect" title="Hypoglycaemia">hypoglycaemia</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Medical gases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oxygen" title="Oxygen">Oxygen</a></li> <li><a href="/wiki/Carbon_dioxide" title="Carbon dioxide">Carbon dioxide</a></li> <li><a href="/wiki/Helium" title="Helium">Helium</a></li> <li><a href="/wiki/Nitrogen" 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