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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="x1VR2hmCXkWwtCI6MxkAhOA34XH5ZZd6SDEkPO28hG1IoBdXfZdT5pDSGJSeAApnx881nUyvhAk5bgIdnxQcQA==" /> <meta name="citation_title" content="Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women" /> <meta name="citation_publication_date" content="2016/01/09" /> <meta name="citation_journal_title" content="The American journal of clinical nutrition" /> <meta name="citation_author" content="maricela haghiac" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women" /> <meta name="twitter:title" content="Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women" /> <meta name="twitter:description" content="The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on" /> <meta name="twitter:image" content="https://0.academia-photos.com/10666367/32013612/29130973/s200_maricela.haghiac.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women" /> <meta property="og:title" content="Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on" /> <meta property="article:author" content="https://metrohealth.academia.edu/maricelahaghiac" /> <meta name="description" content="The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on" /> <title>(PDF) n-3 Fatty Acid Supplementation Effects on Placental Lipids</title> <link rel="canonical" href="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '1086bfafd5b5c78bcba1554863994f709e2874d0'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733306309000); window.Aedu.timeDifference = new Date().getTime() - 1733306309000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on the placenta is poorly understood. We aimed to investigate whether n-3 supplementation during pregnancy affects lipid metabolism in the placentas of overweight and obese women at term. A secondary analysis of a double-blind randomized controlled trial was conducted in healthy overweight and obese pregnant women who were randomly assigned to DHA plus EPA (2 g/d) or placebo twice a day from early pregnancy to term. Placental FA uptake, esterification, and oxidation pathways were studied by measuring the expression of key genes in the placental tissue of women supplemented with placebo and n-3 and in vitro in isolated trophoblast cells in response to DHA and EPA treatment. Total lipid content was significantly lower in the placentas of overw...","author":[{"@context":"https://schema.org","@type":"Person","name":"maricela haghiac"}],"contributor":[],"dateCreated":"2022-10-03","dateModified":"2024-11-30","datePublished":"2016-01-09","headline":"Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women","image":"https://attachments.academia-assets.com/91920756/thumbnails/1.jpg","inLanguage":"en","keywords":["Engineering","Endocrinology","Obesity","Medicine","Pregnancy","Overweight","Internal Medicine","Placenta","Young Adult","Dietary Supplements","Lipid metabolism","Body Mass Index","Eicosapentaenoic Acid","Medical and Health Sciences"],"publication":"The American journal of clinical nutrition","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"metrohealth"}],"thumbnailUrl":"https://attachments.academia-assets.com/91920756/thumbnails/1.jpg","url":"https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women"}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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[{"id":91920756,"identifier":"Attachment_91920756","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":87806935,"created_at":"2022-10-03T07:41:30.406-07:00","from_world_paper_id":216561340,"updated_at":"2024-11-30T09:37:53.221-08:00","_data":{"abstract":"The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on the placenta is poorly understood. We aimed to investigate whether n-3 supplementation during pregnancy affects lipid metabolism in the placentas of overweight and obese women at term. A secondary analysis of a double-blind randomized controlled trial was conducted in healthy overweight and obese pregnant women who were randomly assigned to DHA plus EPA (2 g/d) or placebo twice a day from early pregnancy to term. Placental FA uptake, esterification, and oxidation pathways were studied by measuring the expression of key genes in the placental tissue of women supplemented with placebo and n-3 and in vitro in isolated trophoblast cells in response to DHA and EPA treatment. Total lipid content was significantly lower in the placentas of overw...","ai_title_tag":"n-3 Fatty Acid Supplementation Effects on Placental Lipids","publication_date":"2016,1,9","publication_name":"The American journal of clinical nutrition"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [10666367]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":91920756,"attachmentType":"pdf"}"><img alt="First page of “Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/91920756/mini_magick20221003-1-186f2fs.png?1664808458" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="10666367" href="https://metrohealth.academia.edu/maricelahaghiac"><img alt="Profile image of maricela haghiac" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/10666367/32013612/29130973/s65_maricela.haghiac.jpg" />maricela haghiac</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2016, The American journal of clinical nutrition</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n-3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on the placenta is poorly understood. We aimed to investigate whether n-3 supplementation during pregnancy affects lipid metabolism in the placentas of overweight and obese women at term. A secondary analysis of a double-blind randomized controlled trial was conducted in healthy overweight and obese pregnant women who were randomly assigned to DHA plus EPA (2 g/d) or placebo twice a day from early pregnancy to term. Placental FA uptake, esterification, and oxidation pathways were studied by measuring the expression of key genes in the placental tissue of women supplemented with placebo and n-3 and in vitro in isolated trophoblast cells in response to DHA and EPA treatment. Total lipid content was significantly lower in the placentas of overw...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":91920756,"attachmentType":"pdf","workUrl":"https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":91920756,"attachmentType":"pdf","workUrl":"https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="91920756" data-landing_url="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="75093854" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels">Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="125459641" href="https://independent.academia.edu/FernandaAlvarado74">Fernanda Alvarado</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Placenta, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Placentas of obese women have higher lipid content compared to lean women. We have previously shown that supplementation of overweight and obese women with omega-3 fatty acids decreases placental esterification pathways and total lipid content in a mid-western population (Ohio). We hypothesized that placental lipid accumulation and inflammation would be similar between lean and obese women living in a region of high omega-3 intake, such as Hawaii. Fifty-five healthy, normal glucose tolerant women from Honolulu Hawaii, dichotomized based on pre-pregnancy BMI into lean (BMI &lt;25 kg/m, n = 29) and obese (BMI &gt;30 kg/m, n = 26), were recruited at scheduled term cesarean delivery. Maternal plasma DHA levels were analyzed by mass spectrometry. Expression of key genes involved in fatty acid oxidation and esterification were measured in placental tissue using qPCR. Total lipids were extracted from placental tissue via the Folch method. TNF-α concentration was measured by enzyme-linked i...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels","attachmentId":83002000,"attachmentType":"pdf","work_url":"https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="56958101" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism">Effect of Maternal Obesity on Placental Lipid Metabolism</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="140659986" href="https://independent.academia.edu/HoppelCharles">Charles Hoppel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Endocrinology, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Obese women, on average, give birth to babies with high fat mass. Placental lipid metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is affected by maternal obesity is poorly understood. We hypothesized that fatty acid (FA) accumulation (esterification) is higher and FA β-oxidation (FAO) is lower in placentas from obese, compared with lean women. We assessed acylcarnitine profiles (lipid oxidation intermediates) in mother-baby-placenta triads, in addition to lipid content, and messenger RNA (mRNA)/protein expression of key regulators of FA metabolism pathways in placentas of lean and obese women with normal glucose tolerance recruited at scheduled term Cesarean delivery. In isolated trophoblasts, we measured [3H]-palmitate metabolism. Placentas of obese women had 17.5% (95% confidence interval: 6.1, 28.7%) more lipid than placentas of lean women, and higher mRNA and protein expression of FA esterification regulators (e.g., peroxisome prolif...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Maternal Obesity on Placental Lipid Metabolism","attachmentId":72090144,"attachmentType":"pdf","work_url":"https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="104351068" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104351068/Maternal_Fatty_Acid_Metabolism_in_Pregnancy_and_Its_Consequences_in_the_Feto_Placental_Development">Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43746830" href="https://independent.academia.edu/AsimDuttaroy">Asim K Duttaroy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Physiology, 2022</p><p class="ds-related-work--abstract ds2-5-body-sm">During pregnancy, maternal plasma fatty acids are critically required for cell growth and development, cell signaling, and the development of critical structural and functional aspects of the feto-placental unit. 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dietary fatty acids and their roles in human placental development","attachmentId":104105438,"attachmentType":"pdf","work_url":"https://www.academia.edu/104351058/Maternal_dietary_fatty_acids_and_their_roles_in_human_placental_development","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/104351058/Maternal_dietary_fatty_acids_and_their_roles_in_human_placental_development"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="54230968" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54230968/Docosahexaenoic_acid_supply_in_pregnancy_affects_placental_expression_of_fatty_acid_transport_proteins">Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33136580" href="https://granada.academia.edu/CFolgoso">Cristina Campoy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American journal of clinical nutrition, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Better understanding of the mechanisms involved in docosahexaenoic acid (DHA) transfer to the neonate may contribute to improve dietary support for infants born prematurely to mothers with placental lipid transport disorders. We studied whether DHA supplements modify the messenger RNA (mRNA) expression of placental lipid transport proteins to allow a selective transfer of DHA to the fetus. Healthy pregnant women (n = 136) received, in a double-blind randomized trial, 500 mg DHA + 150 mg eicosapentaenoic acid, 400 microg 5-methyl-tetrahydrofolic acid, 500 mg DHA + 400 microg 5-methyl-tetrahydrofolic acid, or placebo during the second half of gestation. We analyzed the fatty acid composition of maternal and cord blood phospholipids and of placenta; we quantified placental mRNA expression of fatty acid-transport protein 1 (FATP-1), FATP-4, FATP-6, fatty acid translocase, fatty acid-binding protein (FABP) plasma membrane, heart-FABP, adipocyte-FABP, and brain-FABP. The mRNA expression o...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins","attachmentId":70706252,"attachmentType":"pdf","work_url":"https://www.academia.edu/54230968/Docosahexaenoic_acid_supply_in_pregnancy_affects_placental_expression_of_fatty_acid_transport_proteins","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54230968/Docosahexaenoic_acid_supply_in_pregnancy_affects_placental_expression_of_fatty_acid_transport_proteins"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="65212380" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/65212380/Human_placenta_metabolizes_fatty_acids_implications_for_fetal_fatty_acid_oxidation_disorders_and_maternal_liver_diseases">Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="80855" href="https://upenn.academia.edu/MichaelBennett">Michael Bennett</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American journal of physiology. Endocrinology and metabolism, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">The role of fat metabolism during human pregnancy and in placental growth and function is poorly understood. Mitochondrial fatty acid oxidation disorders in an affected fetus are associated with maternal diseases of pregnancy, including preeclampsia, acute fatty liver of pregnancy, and the hemolysis, elevated liver enzymes, and low platelets syndrome called HELLP. We have investigated the developmental expression and activity of six fatty acid beta-oxidation enzymes at various gestational-age human placentas. Placental specimens exhibited abundant expression of all six enzymes, as assessed by immunohistochemical and immunoblot analyses, with greater staining in syncytiotrophoblasts compared with other placental cell types. beta-Oxidation enzyme activities in placental tissues were higher early in gestation and lower near term. Trophoblast cells in culture oxidized tritium-labeled palmitate and myristate in substantial amounts, indicating that the human placenta utilizes fatty acids ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases","attachmentId":76911651,"attachmentType":"pdf","work_url":"https://www.academia.edu/65212380/Human_placenta_metabolizes_fatty_acids_implications_for_fetal_fatty_acid_oxidation_disorders_and_maternal_liver_diseases","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65212380/Human_placenta_metabolizes_fatty_acids_implications_for_fetal_fatty_acid_oxidation_disorders_and_maternal_liver_diseases"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="96191722" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96191722/Obesity_downregulates_lipid_metabolism_genes_in_first_trimester_placenta">Obesity downregulates lipid metabolism genes in first trimester placenta</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29754284" href="https://independent.academia.edu/WhiteKatharine">Katharine White</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scientific Reports</p><p class="ds-related-work--abstract ds2-5-body-sm">Placentas of obese women have low mitochondrial β-oxidation of fatty acids (FA) and accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing placental efficiency. We hypothesized that placental FA metabolism is impaired in women with obesity from early pregnancy. We assessed expression of key regulators of FA metabolism in first trimester placentas of lean and obese women. Maternal fasting triglyceride and insulin levels were measured in plasma collected at the time of procedure. Expression of genes associated with FA oxidation (FAO; ACOX1, CPT2, AMPKα), FA uptake (LPL, LIPG, MFSD2A), FA synthesis (ACACA) and storage (PLIN2) were significantly reduced in placentas of obese compared to lean women. This effect was exacerbated in placentas of male fetuses. Placental ACOX1 protein was higher in women with obesity and correlated with maternal circulating triglycerides. The PPARα pathway was enriched for placental genes impacted by obesity, and PPARα antagonism...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Obesity downregulates lipid metabolism genes in first trimester placenta","attachmentId":98158398,"attachmentType":"pdf","work_url":"https://www.academia.edu/96191722/Obesity_downregulates_lipid_metabolism_genes_in_first_trimester_placenta","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/96191722/Obesity_downregulates_lipid_metabolism_genes_in_first_trimester_placenta"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="111276758" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity">Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38338769" href="https://independent.academia.edu/JuanMalacara">Juan Malacara</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Cell and Developmental Biology, 2022</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity","attachmentId":108858012,"attachmentType":"pdf","work_url":"https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":91920756,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":91920756,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_91920756" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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href="https://independent.academia.edu/SamanthaRobbins6">Samantha Bedell</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Placenta, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment","attachmentId":104707041,"attachmentType":"pdf","work_url":"https://www.academia.edu/105183446/Altered_maternal_and_placental_lipid_metabolism_and_fetal_fat_development_in_obesity_Current_knowledge_and_advances_in_non_invasive_assessment","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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