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id="Pill-react-component-c240d999-8492-4a54-bf9f-9d17bc110120"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Juan Malacara</h3></div><div class="js-work-strip profile--work_container" data-work-id="111276759"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1"><img alt="Research paper thumbnail of Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1">Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, Nov 1, 1972</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p &lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276759"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276759"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276759; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276759]").text(description); $(".js-view-count[data-work-id=111276759]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276759; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276759']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276759, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276759]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276759,"title":"Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1","translated_title":"","metadata":{"abstract":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p \u0026lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...","publisher":"Oxford University Press","publication_date":{"day":1,"month":11,"year":1972,"errors":{}},"publication_name":"Endocrinology"},"translated_abstract":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p \u0026lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...","internal_url":"https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1","translated_internal_url":"","created_at":"2023-12-12T16:40:44.853-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p \u0026lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":52562,"name":"Growth Hormone","url":"https://www.academia.edu/Documents/in/Growth_Hormone"},{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":64559,"name":"Progesterone","url":"https://www.academia.edu/Documents/in/Progesterone"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":95704,"name":"Hypothalamus","url":"https://www.academia.edu/Documents/in/Hypothalamus"},{"id":293670,"name":"Pituitary Gland","url":"https://www.academia.edu/Documents/in/Pituitary_Gland"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine"},{"id":1295208,"name":"Estradiol","url":"https://www.academia.edu/Documents/in/Estradiol"},{"id":1619820,"name":"Pentobarbital","url":"https://www.academia.edu/Documents/in/Pentobarbital"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3545627,"name":"Drug synergism","url":"https://www.academia.edu/Documents/in/Drug_synergism"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":36980208,"url":"https://doi.org/10.1210/endo-91-5-1189"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity"><img alt="Research paper thumbnail of Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity" class="work-thumbnail" src="https://attachments.academia-assets.com/108858012/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity">Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity</a></div><div class="wp-workCard_item"><span>Frontiers in Cell and Developmental Biology</span><span>, Mar 25, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adverse environmental factors in early life result in fetal metabolic programming and increased r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db8115572cb58d0268050c38ae0d8e9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858012,"asset_id":111276758,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858012/download_file?st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276758; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276758]").text(description); $(".js-view-count[data-work-id=111276758]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276758; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276758']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276758, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "db8115572cb58d0268050c38ae0d8e9f" } } $('.js-work-strip[data-work-id=111276758]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276758,"title":"Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity","translated_title":"","metadata":{"publisher":"Frontiers Media","grobid_abstract":"Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.","publication_date":{"day":25,"month":3,"year":2022,"errors":{}},"publication_name":"Frontiers in Cell and Developmental Biology","grobid_abstract_attachment_id":108858012},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity","translated_internal_url":"","created_at":"2023-12-12T16:40:44.641-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108858012,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858012/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108858012/download_file?st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Placental_Nutrient_Transporters_and_Mate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858012/pdf-libre.pdf?1702428636=\u0026response-content-disposition=attachment%3B+filename%3DPlacental_Nutrient_Transporters_and_Mate.pdf\u0026Expires=1734023512\u0026Signature=TnwCZU3PkRGj6g-FQge0HMano3C6DecebG-5A0iTHwWXnaRcY0JXvUmCeSsSDm6HfKQSd3we3b7sbjQXTU31wIiKqfpAqjEMezVvGMJD4CvAjouk6~RwqrLknaH5Fzc3ylAGkPVXcYgqecRUqTHRYzPDXO9lwWal2HU2hzwYVnaN9za4FS7PnxOXHP18xlSgxud38uLBEtGDXuHfUHAZ3sKyTrNwlRfwOY~oS~bAE0X8~pH1fHxidxEQY43znnA72PaKypuk2-SsLBDEfivCVPIW3nfpyAt1~GlRGOLNsTN1d7HgAdflCY4jq~VwzIyDnTbDFWgiDck7CsM2xdG1iA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[{"id":108858012,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858012/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108858012/download_file?st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Placental_Nutrient_Transporters_and_Mate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858012/pdf-libre.pdf?1702428636=\u0026response-content-disposition=attachment%3B+filename%3DPlacental_Nutrient_Transporters_and_Mate.pdf\u0026Expires=1734023512\u0026Signature=TnwCZU3PkRGj6g-FQge0HMano3C6DecebG-5A0iTHwWXnaRcY0JXvUmCeSsSDm6HfKQSd3we3b7sbjQXTU31wIiKqfpAqjEMezVvGMJD4CvAjouk6~RwqrLknaH5Fzc3ylAGkPVXcYgqecRUqTHRYzPDXO9lwWal2HU2hzwYVnaN9za4FS7PnxOXHP18xlSgxud38uLBEtGDXuHfUHAZ3sKyTrNwlRfwOY~oS~bAE0X8~pH1fHxidxEQY43znnA72PaKypuk2-SsLBDEfivCVPIW3nfpyAt1~GlRGOLNsTN1d7HgAdflCY4jq~VwzIyDnTbDFWgiDck7CsM2xdG1iA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":160393,"name":"Small for Gestational Age","url":"https://www.academia.edu/Documents/in/Small_for_Gestational_Age"}],"urls":[{"id":36980207,"url":"https://doi.org/10.3389/fcell.2022.822527"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276754/S%C3%ADndrome_de_ovario_poliqu%C3%ADsticoPosici%C3%B3n_de_la_Sociedad_Mexicana_de_Nutrici%C3%B3n_y_Endocrinolog%C3%ADa"><img alt="Research paper thumbnail of Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología" class="work-thumbnail" src="https://attachments.academia-assets.com/108858011/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276754/S%C3%ADndrome_de_ovario_poliqu%C3%ADsticoPosici%C3%B3n_de_la_Sociedad_Mexicana_de_Nutrici%C3%B3n_y_Endocrinolog%C3%ADa">Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en su presentación clínica, de probable origen genético, pero también influenciado por factores ambientales como la nutrición y la actividad física. El SOP es el problema endocrino más frecuente de la mujer en edad reproductiva, con una prevalencia aproximada de 6%. La etiología del SOP es desconocida, pero se han podido demostrar alteraciones de tipo neuroendocrino, caracterizadas por disfunción gonadotrópica, y anormalidades metabólicas, determinadas por resistencia a la insulina. El diagnóstico del SOP se basa en la presencia de oligoovulación o anovulación, hiperandrogenismo clínico o bioquímico, y la imagen de ovarios poliquísticos al ultrasonido. El tratamiento médico del SOP debe ser integral, teniendo en cuenta las alteraciones metabólicas y conjuntamente los motivos específicos de consulta de la paciente. En general, el pronóstico para la fertilidad y para el control de los síntomas clínicos como hirsutismo o acné es favorable. Sin embargo, las pacientes con SOP deben ser evaluadas a largo plazo para evitar en lo posible el desarrollo de enfermedades metabólicas como la diabetes mellitus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a728b93a67d63209d97756ce4a69cfbc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858011,"asset_id":111276754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858011/download_file?st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276754]").text(description); $(".js-view-count[data-work-id=111276754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276754, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a728b93a67d63209d97756ce4a69cfbc" } } $('.js-work-strip[data-work-id=111276754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276754,"title":"Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología","translated_title":"","metadata":{"grobid_abstract":"El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en su presentación clínica, de probable origen genético, pero también influenciado por factores ambientales como la nutrición y la actividad física. 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El SOP es el problema endocrino más frecuente de la mujer en edad reproductiva, con una prevalencia aproximada de 6%. La etiología del SOP es desconocida, pero se han podido demostrar alteraciones de tipo neuroendocrino, caracterizadas por disfunción gonadotrópica, y anormalidades metabólicas, determinadas por resistencia a la insulina. El diagnóstico del SOP se basa en la presencia de oligoovulación o anovulación, hiperandrogenismo clínico o bioquímico, y la imagen de ovarios poliquísticos al ultrasonido. El tratamiento médico del SOP debe ser integral, teniendo en cuenta las alteraciones metabólicas y conjuntamente los motivos específicos de consulta de la paciente. En general, el pronóstico para la fertilidad y para el control de los síntomas clínicos como hirsutismo o acné es favorable. 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APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES&quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276752"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276752"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276752; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276752]").text(description); $(".js-view-count[data-work-id=111276752]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276752; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276752']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276752, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276752]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276752,"title":"Reconocimiento en La FC a Anita Hoffmann","translated_title":"","metadata":{"abstract":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","publication_date":{"day":null,"month":null,"year":2004,"errors":{}}},"translated_abstract":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","internal_url":"https://www.academia.edu/111276752/Reconocimiento_en_La_FC_a_Anita_Hoffmann","translated_internal_url":"","created_at":"2023-12-12T16:40:43.670-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Reconocimiento_en_La_FC_a_Anita_Hoffmann","translated_slug":"","page_count":null,"language":"es","content_type":"Work","summary":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"},{"id":1236,"name":"Art","url":"https://www.academia.edu/Documents/in/Art"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276751"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276751/SUN_585_Associations_Between_UCP1_rs1800592_UCP2_rs6593366_and_UCP3_rs1800849_with_Fasting_Glucose_Body_Mass_Index_and_Energy_Expenditure"><img alt="Research paper thumbnail of SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure" class="work-thumbnail" src="https://attachments.academia-assets.com/108857982/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276751/SUN_585_Associations_Between_UCP1_rs1800592_UCP2_rs6593366_and_UCP3_rs1800849_with_Fasting_Glucose_Body_Mass_Index_and_Energy_Expenditure">SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure</a></div><div class="wp-workCard_item"><span>Journal of the Endocrine Society</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carrier superfamily and play an important role in energy homeostasis. UCP-1 is expressed mostly in brown adipose tissue (BAT) and act in the thermogenesis and regulation of energy expenditure. UCP-2 has a role in the metabolism of fatty acids direct and indirectly path insulin secretion. UCP-3 is specific of skeletal muscle and BAT and may affects the adaptive and translocation of fatty acids. Genetic polymorphisms in these proteins have been associated with obesity, as rs1800592 (-3826 A/G) in UCP-1 gene. The rs659366 (-866GA) UCP-2 has being associated with high expression of its RNAm, decrease of obesity risk, and increase of energy expenditure. The rs1800849 (-55CT) UCP-3 has been associated with low risk of type 2 Diabetes Mellitus, but its association with body mass index is controversial. Objective: To analyze the association of the polymorphisms rs1800592 UCP-1, rs659366 UCP-2, and rs...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d93addfaf9db9d77291f1a9f82cc83b9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108857982,"asset_id":111276751,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108857982/download_file?st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276751"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276751"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276751; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276751]").text(description); $(".js-view-count[data-work-id=111276751]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276751; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276751']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276751, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d93addfaf9db9d77291f1a9f82cc83b9" } } $('.js-work-strip[data-work-id=111276751]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276751,"title":"SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure","translated_title":"","metadata":{"abstract":"Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carrier superfamily and play an important role in energy homeostasis. 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organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A total of 1,030 diabetic patients were studied in order to identify factors associated with vari...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. 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Albuminuria was assessed with a radioimmunoassay procedure and fo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276744]").text(description); $(".js-view-count[data-work-id=111276744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276744,"title":"[Risk factors of the complications of diabetes mellitus]","translated_title":"","metadata":{"abstract":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. 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Albuminuria was assessed with a radioimmunoassay procedure and fo...","publication_name":"Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición"},"translated_abstract":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...","internal_url":"https://www.academia.edu/111276744/_Risk_factors_of_the_complications_of_diabetes_mellitus_","translated_internal_url":"","created_at":"2023-12-12T16:40:40.143-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Risk_factors_of_the_complications_of_diabetes_mellitus_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":63360,"name":"Discriminant Analysis","url":"https://www.academia.edu/Documents/in/Discriminant_Analysis"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":420633,"name":"Diabetes complications","url":"https://www.academia.edu/Documents/in/Diabetes_complications"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276743"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276743/Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study"><img alt="Research paper thumbnail of Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276743/Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study">Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study</a></div><div class="wp-workCard_item"><span>Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p&lt;0.0001) and eGFR decreased (p&lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p&lt;0.029)...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276743"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276743"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276743; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276743]").text(description); $(".js-view-count[data-work-id=111276743]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276743; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276743']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276743, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276743]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276743,"title":"Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study","translated_title":"","metadata":{"abstract":"Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p\u0026lt;0.029)...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Experimental and clinical endocrinology \u0026 diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association"},"translated_abstract":"Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p\u0026lt;0.029)...","internal_url":"https://www.academia.edu/111276743/Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study","translated_internal_url":"","created_at":"2023-12-12T16:40:39.981-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p\u0026lt;0.029)...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":23243,"name":"Type 2 Diabetes","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":60979,"name":"Glycation","url":"https://www.academia.edu/Documents/in/Glycation"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":96573,"name":"Diabetic Retinopathy","url":"https://www.academia.edu/Documents/in/Diabetic_Retinopathy"},{"id":227296,"name":"Microalbuminuria","url":"https://www.academia.edu/Documents/in/Microalbuminuria"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":261560,"name":"Nephropathy","url":"https://www.academia.edu/Documents/in/Nephropathy"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde"},{"id":1760562,"name":"Retinopathy","url":"https://www.academia.edu/Documents/in/Retinopathy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276742"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_"><img alt="Research paper thumbnail of [Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_">[Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]</a></div><div class="wp-workCard_item"><span>Ginecología y obstetricia de México</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Frequency an severity of physical and emotional symptoms in young female students from two cities...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276742"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276742"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276742; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276742]").text(description); $(".js-view-count[data-work-id=111276742]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276742; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276742']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276742, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276742]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276742,"title":"[Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]","translated_title":"","metadata":{"abstract":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Ginecología y obstetricia de México"},"translated_abstract":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...","internal_url":"https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_","translated_internal_url":"","created_at":"2023-12-12T16:40:39.457-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":16038,"name":"Menstruation","url":"https://www.academia.edu/Documents/in/Menstruation"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety"},{"id":43881,"name":"Mexico","url":"https://www.academia.edu/Documents/in/Mexico"},{"id":89021,"name":"Constipation","url":"https://www.academia.edu/Documents/in/Constipation"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":118928,"name":"Child and Adolescent Psychology","url":"https://www.academia.edu/Documents/in/Child_and_Adolescent_Psychology"},{"id":157943,"name":"Depressive Disorder","url":"https://www.academia.edu/Documents/in/Depressive_Disorder"},{"id":176895,"name":"Breast","url":"https://www.academia.edu/Documents/in/Breast"},{"id":182850,"name":"Menstrual Cycle","url":"https://www.academia.edu/Documents/in/Menstrual_Cycle"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population"},{"id":617771,"name":"MEXICO","url":"https://www.academia.edu/Documents/in/MEXICO-2015"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1"},{"id":740283,"name":"Thirst","url":"https://www.academia.edu/Documents/in/Thirst"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276741"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111276741/_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_"><img alt="Research paper thumbnail of [The relationship of the alimentary habits with standing height, weight and body surface area (author's transl)]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111276741/_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_">[The relationship of the alimentary habits with standing height, weight and body surface area (author's transl)]</a></div><div class="wp-workCard_item"><span>Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276741"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276741"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276741; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276741]").text(description); $(".js-view-count[data-work-id=111276741]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276741; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276741']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276741, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276741]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276741,"title":"[The relationship of the alimentary habits with standing height, weight and body surface area (author's transl)]","translated_title":"","metadata":{"publication_name":"Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición"},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276741/_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_","translated_internal_url":"","created_at":"2023-12-12T16:40:38.941-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":261,"name":"Geography","url":"https://www.academia.edu/Documents/in/Geography"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":43881,"name":"Mexico","url":"https://www.academia.edu/Documents/in/Mexico"},{"id":54961,"name":"Growth","url":"https://www.academia.edu/Documents/in/Growth"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":107106,"name":"Meat","url":"https://www.academia.edu/Documents/in/Meat"},{"id":369093,"name":"Food habits","url":"https://www.academia.edu/Documents/in/Food_habits"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":617771,"name":"MEXICO","url":"https://www.academia.edu/Documents/in/MEXICO-2015"},{"id":892682,"name":"Body Height","url":"https://www.academia.edu/Documents/in/Body_Height"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model"><img alt="Research paper thumbnail of Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model">Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate in a canine model the induction of tolerance to renal transplantation after splenecto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276740; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276740]").text(description); $(".js-view-count[data-work-id=111276740]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276740; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276740']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276740, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276740]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276740,"title":"Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model","translated_title":"","metadata":{"abstract":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","internal_url":"https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model","translated_internal_url":"","created_at":"2023-12-12T16:40:38.593-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":58379,"name":"Renal transplantation","url":"https://www.academia.edu/Documents/in/Renal_transplantation"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":215075,"name":"Experimental Study","url":"https://www.academia.edu/Documents/in/Experimental_Study"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":894787,"name":"Immune Tolerance","url":"https://www.academia.edu/Documents/in/Immune_Tolerance"},{"id":1311261,"name":"Hemoglobins","url":"https://www.academia.edu/Documents/in/Hemoglobins"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3834134,"name":"leukocyte Count","url":"https://www.academia.edu/Documents/in/leukocyte_Count"}],"urls":[{"id":36980202,"url":"https://api.elsevier.com/content/article/PII:S0041134509017266?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276739"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria"><img alt="Research paper thumbnail of Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria">Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria</a></div><div class="wp-workCard_item"><span>Nephron</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes melli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276739"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276739"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276739; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276739]").text(description); $(".js-view-count[data-work-id=111276739]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276739; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276739']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276739, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276739]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276739,"title":"Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria","translated_title":"","metadata":{"abstract":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","publisher":"S. Karger AG","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Nephron"},"translated_abstract":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","internal_url":"https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria","translated_internal_url":"","created_at":"2023-12-12T16:40:38.375-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71511,"name":"Diabetes 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class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276738/Age_at_Menopause_in_Women_with_Type_2_Diabetes_Mellitus">Age at Menopause in Women with Type 2 Diabetes Mellitus</a></div><div class="wp-workCard_item"><span>Menopause</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6872e169f99423d2a05a3229b401bb5d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858010,"asset_id":111276738,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858010/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" 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href="https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_"><img alt="Research paper thumbnail of Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_">Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276737"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276737"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276737; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276737]").text(description); $(".js-view-count[data-work-id=111276737]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276737; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276737']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276737, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276737]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276737,"title":"Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*","translated_title":"","metadata":{"abstract":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","publisher":"The Endocrine Society","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Endocrinology"},"translated_abstract":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","internal_url":"https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_","translated_internal_url":"","created_at":"2023-12-12T16:40:37.895-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":95704,"name":"Hypothalamus","url":"https://www.academia.edu/Documents/in/Hypothalamus"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":445229,"name":"Gonadotropin Releasing Hormone","url":"https://www.academia.edu/Documents/in/Gonadotropin_Releasing_Hormone"},{"id":528223,"name":"phospholipases A2","url":"https://www.academia.edu/Documents/in/phospholipases_A2"},{"id":541937,"name":"Stimulation","url":"https://www.academia.edu/Documents/in/Stimulation"},{"id":669908,"name":"EGTA","url":"https://www.academia.edu/Documents/in/EGTA"},{"id":1130425,"name":"Luteinizing Hormone","url":"https://www.academia.edu/Documents/in/Luteinizing_Hormone"},{"id":1866509,"name":"Indomethacin","url":"https://www.academia.edu/Documents/in/Indomethacin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[{"id":36980199,"url":"http://academic.oup.com/endo/article-pdf/121/4/1483/10668504/endo1483.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276736"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus"><img alt="Research paper thumbnail of Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/108858019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus">Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus</a></div><div class="wp-workCard_item"><span>Diabetic Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalb...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec14e307ab3276cfd35e4879cf245f46" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858019,"asset_id":111276736,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276736"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276736"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276736; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276736]").text(description); $(".js-view-count[data-work-id=111276736]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276736; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276736']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276736, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ec14e307ab3276cfd35e4879cf245f46" } } $('.js-work-strip[data-work-id=111276736]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276736,"title":"Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Diabetic Medicine","grobid_abstract_attachment_id":108858019},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus","translated_internal_url":"","created_at":"2023-12-12T16:40:37.664-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108858019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858019/thumbnails/1.jpg","file_name":"j.1464-5491.2011.03380.x20231213-1-gnpjny.pdf","download_url":"https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_exercise_intensity_on_albuminu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858019/j.1464-5491.2011.03380.x20231213-1-gnpjny-libre.pdf?1702428631=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_exercise_intensity_on_albuminu.pdf\u0026Expires=1734023513\u0026Signature=f3I9iVXlBl3xNKqV5xIcjF1KWxiWszZAldGLADdJ504lumK4m5pjqvDwgSS~1D00PVYHR-wGiVLMf1w~e-aaH~nSDKdTKjMwt4X-7dpnyzeBnxCc~IXzfk9FL5EjxxaMwR93CSGbDT9dDSxM9HzsKatDAF9fpuh~y4BBfOOTfCKjukG2DdolUXMcpptls7RxCPoNjs7WT7403rAM7upHCHULTenWdiBWyGUxdgWMlrP2SaYQOE0mp6PHOCRy32RuwXClGUJhrXQUnnsw6-thrNBC8ansh7DUTmbIE-v9ZGHGSxV6mMkSNHjI0HOvQMNnyghSJjf8hftUbAUU8ghHRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[{"id":108858019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858019/thumbnails/1.jpg","file_name":"j.1464-5491.2011.03380.x20231213-1-gnpjny.pdf","download_url":"https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_exercise_intensity_on_albuminu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858019/j.1464-5491.2011.03380.x20231213-1-gnpjny-libre.pdf?1702428631=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_exercise_intensity_on_albuminu.pdf\u0026Expires=1734023513\u0026Signature=f3I9iVXlBl3xNKqV5xIcjF1KWxiWszZAldGLADdJ504lumK4m5pjqvDwgSS~1D00PVYHR-wGiVLMf1w~e-aaH~nSDKdTKjMwt4X-7dpnyzeBnxCc~IXzfk9FL5EjxxaMwR93CSGbDT9dDSxM9HzsKatDAF9fpuh~y4BBfOOTfCKjukG2DdolUXMcpptls7RxCPoNjs7WT7403rAM7upHCHULTenWdiBWyGUxdgWMlrP2SaYQOE0mp6PHOCRy32RuwXClGUJhrXQUnnsw6-thrNBC8ansh7DUTmbIE-v9ZGHGSxV6mMkSNHjI0HOvQMNnyghSJjf8hftUbAUU8ghHRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography"},{"id":58497,"name":"Metabolic control analysis","url":"https://www.academia.edu/Documents/in/Metabolic_control_analysis"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":100336,"name":"Body Composition","url":"https://www.academia.edu/Documents/in/Body_Composition"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise"},{"id":149446,"name":"Diabetic","url":"https://www.academia.edu/Documents/in/Diabetic"},{"id":227296,"name":"Microalbuminuria","url":"https://www.academia.edu/Documents/in/Microalbuminuria"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption"}],"urls":[{"id":36980198,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1464-5491.2011.03380.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4025581" id="papers"><div class="js-work-strip profile--work_container" data-work-id="111276759"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1"><img alt="Research paper thumbnail of Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1">Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, Nov 1, 1972</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p &lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276759"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276759"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276759; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276759]").text(description); $(".js-view-count[data-work-id=111276759]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276759; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276759']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276759, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276759]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276759,"title":"Elevation of Plasma Radioimmunoassayable Growth Hormone in the Rat Induced by Porcine Hypothalamic Extract1","translated_title":"","metadata":{"abstract":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p \u0026lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...","publisher":"Oxford University Press","publication_date":{"day":1,"month":11,"year":1972,"errors":{}},"publication_name":"Endocrinology"},"translated_abstract":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. At ten minutes following the injection of 90% methanol extracts of 10 porcine hypothalamic fragments, a significant rise in radioimmunoassayable GH was detected (mean increase in pentobarbital anesthetized rats was 28.5 ng/ml ± 12.3 (SE) VS control of 1.6 ng/ml ± 7.9, p \u0026lt; 0.05). The equivalent of 25 hypothalamic fragments gave a significantly larger response. In a series of animals anesthetized with either pentobarbital or ether, 25 or 10-20 hypothalamic equivalents caused significant elevations of RIA-GH and had no depleting effect on pituitary GH concentration. Without steroid pretreatment, significant effects on plasma GH were not observed even with twenty-five hypothalamic equivalents. In steroid pretreated animals, large doses of vasopressin (5 U) and oxytocin (2 U) also induced GH discharge. TRH at a ...","internal_url":"https://www.academia.edu/111276759/Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1","translated_internal_url":"","created_at":"2023-12-12T16:40:44.853-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Elevation_of_Plasma_Radioimmunoassayable_Growth_Hormone_in_the_Rat_Induced_by_Porcine_Hypothalamic_Extract1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The administration of estradiol benzoate, 50 μg, and progesterone, 25 mg, daily for three days has been found to “sensitize” rats to the growth hormone (GH) releasing activity of hypothalamic extracts. 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TRH at a ...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":52562,"name":"Growth Hormone","url":"https://www.academia.edu/Documents/in/Growth_Hormone"},{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":64559,"name":"Progesterone","url":"https://www.academia.edu/Documents/in/Progesterone"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":95704,"name":"Hypothalamus","url":"https://www.academia.edu/Documents/in/Hypothalamus"},{"id":293670,"name":"Pituitary Gland","url":"https://www.academia.edu/Documents/in/Pituitary_Gland"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine"},{"id":1295208,"name":"Estradiol","url":"https://www.academia.edu/Documents/in/Estradiol"},{"id":1619820,"name":"Pentobarbital","url":"https://www.academia.edu/Documents/in/Pentobarbital"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3545627,"name":"Drug synergism","url":"https://www.academia.edu/Documents/in/Drug_synergism"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":36980208,"url":"https://doi.org/10.1210/endo-91-5-1189"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity"><img alt="Research paper thumbnail of Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity" class="work-thumbnail" src="https://attachments.academia-assets.com/108858012/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity">Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity</a></div><div class="wp-workCard_item"><span>Frontiers in Cell and Developmental Biology</span><span>, Mar 25, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adverse environmental factors in early life result in fetal metabolic programming and increased r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db8115572cb58d0268050c38ae0d8e9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858012,"asset_id":111276758,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858012/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276758; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276758]").text(description); $(".js-view-count[data-work-id=111276758]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276758; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276758']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276758, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "db8115572cb58d0268050c38ae0d8e9f" } } $('.js-work-strip[data-work-id=111276758]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276758,"title":"Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity","translated_title":"","metadata":{"publisher":"Frontiers Media","grobid_abstract":"Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.","publication_date":{"day":25,"month":3,"year":2022,"errors":{}},"publication_name":"Frontiers in Cell and Developmental Biology","grobid_abstract_attachment_id":108858012},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276758/Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity","translated_internal_url":"","created_at":"2023-12-12T16:40:44.641-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108858012,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858012/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108858012/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Placental_Nutrient_Transporters_and_Mate.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858012/pdf-libre.pdf?1702428636=\u0026response-content-disposition=attachment%3B+filename%3DPlacental_Nutrient_Transporters_and_Mate.pdf\u0026Expires=1734023512\u0026Signature=TnwCZU3PkRGj6g-FQge0HMano3C6DecebG-5A0iTHwWXnaRcY0JXvUmCeSsSDm6HfKQSd3we3b7sbjQXTU31wIiKqfpAqjEMezVvGMJD4CvAjouk6~RwqrLknaH5Fzc3ylAGkPVXcYgqecRUqTHRYzPDXO9lwWal2HU2hzwYVnaN9za4FS7PnxOXHP18xlSgxud38uLBEtGDXuHfUHAZ3sKyTrNwlRfwOY~oS~bAE0X8~pH1fHxidxEQY43znnA72PaKypuk2-SsLBDEfivCVPIW3nfpyAt1~GlRGOLNsTN1d7HgAdflCY4jq~VwzIyDnTbDFWgiDck7CsM2xdG1iA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Placental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. 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SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276754/S%C3%ADndrome_de_ovario_poliqu%C3%ADsticoPosici%C3%B3n_de_la_Sociedad_Mexicana_de_Nutrici%C3%B3n_y_Endocrinolog%C3%ADa"><img alt="Research paper thumbnail of Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología" class="work-thumbnail" src="https://attachments.academia-assets.com/108858011/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276754/S%C3%ADndrome_de_ovario_poliqu%C3%ADsticoPosici%C3%B3n_de_la_Sociedad_Mexicana_de_Nutrici%C3%B3n_y_Endocrinolog%C3%ADa">Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en su presentación clínica, de probable origen genético, pero también influenciado por factores ambientales como la nutrición y la actividad física. El SOP es el problema endocrino más frecuente de la mujer en edad reproductiva, con una prevalencia aproximada de 6%. La etiología del SOP es desconocida, pero se han podido demostrar alteraciones de tipo neuroendocrino, caracterizadas por disfunción gonadotrópica, y anormalidades metabólicas, determinadas por resistencia a la insulina. El diagnóstico del SOP se basa en la presencia de oligoovulación o anovulación, hiperandrogenismo clínico o bioquímico, y la imagen de ovarios poliquísticos al ultrasonido. El tratamiento médico del SOP debe ser integral, teniendo en cuenta las alteraciones metabólicas y conjuntamente los motivos específicos de consulta de la paciente. En general, el pronóstico para la fertilidad y para el control de los síntomas clínicos como hirsutismo o acné es favorable. Sin embargo, las pacientes con SOP deben ser evaluadas a largo plazo para evitar en lo posible el desarrollo de enfermedades metabólicas como la diabetes mellitus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a728b93a67d63209d97756ce4a69cfbc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858011,"asset_id":111276754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858011/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276754; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276754]").text(description); $(".js-view-count[data-work-id=111276754]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276754; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276754']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276754, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a728b93a67d63209d97756ce4a69cfbc" } } $('.js-work-strip[data-work-id=111276754]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276754,"title":"Síndrome de ovario poliquísticoPosición de la Sociedad Mexicana de Nutrición y Endocrinología","translated_title":"","metadata":{"grobid_abstract":"El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en su presentación clínica, de probable origen genético, pero también influenciado por factores ambientales como la nutrición y la actividad física. 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Sin embargo, las pacientes con SOP deben ser evaluadas a largo plazo para evitar en lo posible el desarrollo de enfermedades metabólicas como la diabetes mellitus.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"grobid_abstract_attachment_id":108858011},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276754/S%C3%ADndrome_de_ovario_poliqu%C3%ADsticoPosici%C3%B3n_de_la_Sociedad_Mexicana_de_Nutrici%C3%B3n_y_Endocrinolog%C3%ADa","translated_internal_url":"","created_at":"2023-12-12T16:40:43.864-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108858011,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858011/thumbnails/1.jpg","file_name":"er061b.pdf","download_url":"https://www.academia.edu/attachments/108858011/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sindrome_de_ovario_poliquisticoPosicion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858011/er061b-libre.pdf?1702428630=\u0026response-content-disposition=attachment%3B+filename%3DSindrome_de_ovario_poliquisticoPosicion.pdf\u0026Expires=1734023512\u0026Signature=CKCkfsYUVc16jdojo3t5o6zOB59-j51nU5z~BK4D9eYwLcY1N4bhc5bIfNCYK4nsqOi9XlCRBgSN6AgrlX~t3sz4EgTy376BWIe6nzqAVYk497iTgmbjnEYfqtPhxfB9Pg5OSSIEYMLfu8V2qKzMKkmAXKbCGUAaw-NPsSc00XLDfdH-srcBieHAVesu-GhfqDfU5HnNZ3tGzmCA7bKjwz8XBKVxQVIcu1xpCL7WGl-FN8PecrXbd3rNDiFOI7u25NDY325SM~D2Y1h7K30mSNMWGXQI~4HRMFI96aCc4-dJ6s~unn45AtF4TF~hZEUjgGB9uetVuomFKWOoBXWceA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Síndrome_de_ovario_poliquísticoPosición_de_la_Sociedad_Mexicana_de_Nutrición_y_Endocrinología","translated_slug":"","page_count":6,"language":"es","content_type":"Work","summary":"El síndrome de ovario poliquístico (SOP) es un trastorno endocrino y metabólico, heterogéneo en su presentación clínica, de probable origen genético, pero también influenciado por factores ambientales como la nutrición y la actividad física. El SOP es el problema endocrino más frecuente de la mujer en edad reproductiva, con una prevalencia aproximada de 6%. La etiología del SOP es desconocida, pero se han podido demostrar alteraciones de tipo neuroendocrino, caracterizadas por disfunción gonadotrópica, y anormalidades metabólicas, determinadas por resistencia a la insulina. El diagnóstico del SOP se basa en la presencia de oligoovulación o anovulación, hiperandrogenismo clínico o bioquímico, y la imagen de ovarios poliquísticos al ultrasonido. El tratamiento médico del SOP debe ser integral, teniendo en cuenta las alteraciones metabólicas y conjuntamente los motivos específicos de consulta de la paciente. En general, el pronóstico para la fertilidad y para el control de los síntomas clínicos como hirsutismo o acné es favorable. Sin embargo, las pacientes con SOP deben ser evaluadas a largo plazo para evitar en lo posible el desarrollo de enfermedades metabólicas como la diabetes mellitus.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[{"id":108858011,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858011/thumbnails/1.jpg","file_name":"er061b.pdf","download_url":"https://www.academia.edu/attachments/108858011/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sindrome_de_ovario_poliquisticoPosicion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858011/er061b-libre.pdf?1702428630=\u0026response-content-disposition=attachment%3B+filename%3DSindrome_de_ovario_poliquisticoPosicion.pdf\u0026Expires=1734023512\u0026Signature=CKCkfsYUVc16jdojo3t5o6zOB59-j51nU5z~BK4D9eYwLcY1N4bhc5bIfNCYK4nsqOi9XlCRBgSN6AgrlX~t3sz4EgTy376BWIe6nzqAVYk497iTgmbjnEYfqtPhxfB9Pg5OSSIEYMLfu8V2qKzMKkmAXKbCGUAaw-NPsSc00XLDfdH-srcBieHAVesu-GhfqDfU5HnNZ3tGzmCA7bKjwz8XBKVxQVIcu1xpCL7WGl-FN8PecrXbd3rNDiFOI7u25NDY325SM~D2Y1h7K30mSNMWGXQI~4HRMFI96aCc4-dJ6s~unn45AtF4TF~hZEUjgGB9uetVuomFKWOoBXWceA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276752"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276752/Reconocimiento_en_La_FC_a_Anita_Hoffmann"><img alt="Research paper thumbnail of Reconocimiento en La FC a Anita Hoffmann" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276752/Reconocimiento_en_La_FC_a_Anita_Hoffmann">Reconocimiento en La FC a Anita Hoffmann</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN &quot;REFRANERO ZOOLOGICO....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN &quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES&quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276752"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276752"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276752; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276752]").text(description); $(".js-view-count[data-work-id=111276752]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276752; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276752']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276752, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276752]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276752,"title":"Reconocimiento en La FC a Anita Hoffmann","translated_title":"","metadata":{"abstract":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","publication_date":{"day":null,"month":null,"year":2004,"errors":{}}},"translated_abstract":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","internal_url":"https://www.academia.edu/111276752/Reconocimiento_en_La_FC_a_Anita_Hoffmann","translated_internal_url":"","created_at":"2023-12-12T16:40:43.670-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Reconocimiento_en_La_FC_a_Anita_Hoffmann","translated_slug":"","page_count":null,"language":"es","content_type":"Work","summary":"CON MOTIVO DE LA PRESENTACION DEL LIBRO EN DOS TOMOS DE ANITA HOFFMANN \u0026quot;REFRANERO ZOOLOGICO. APOTEGMAS Y OTRAS EXPRESIONES POPULARES SOBRE LOS ANIMALES\u0026quot;, LA COMUNIDAD UNIVERSITARIA HIZO UN RECONOCIMIENTO A LA LABOR ININTERRUMPIDA DE 62 ANOS DE LA PRECURSORA DE LA ACAROLOGIA Y EMBLEMA DE ESTA UNIVERSIDAD. EN EL AUDITORIO CARLOS GRAEF DE LA FACULTAD DE CIENCIAS (FC), RENE DRUCKER COLIN, COORDINADOR DE LA INVESTIGACION CIENTIFICA DE ESTA CASA DE ESTUDIOS, SENALO QUE LA ESPLENDIDA PUBLICACION ES RESULTADO DE UN PASATIEMPO SISTEM TICO Y, SIN DUDA, DE LA PASION DE LA autorA POR EL MUNDO DE LA ZOOLOGIA; REVELA EL ENTUSIASMO DE ANITA HOFFMANN POR LA VIDA Y POR LO VIVO. TAMBIEN PARTICIPARON EN EL RECONOCIMIENTO A LA PROFESORA EMERITA DE LA FC RAMON PERALTA Y FABI, DIRECTOR DE LA DEPENDENCIA; TILA MARIA PEREZ, DIRECTORA DEL INSTITUTO DE BIOLOGIA Y DISCIPULA DE LA RECONOCIDA INVESTIGADORA; JUAN MORALES MALACARA, COORDINADOR DEL DEPARTAMENTO DE BIOLOGIA COMPARADA DE LA FC; ARMANDO SAN...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"},{"id":1236,"name":"Art","url":"https://www.academia.edu/Documents/in/Art"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276751"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276751/SUN_585_Associations_Between_UCP1_rs1800592_UCP2_rs6593366_and_UCP3_rs1800849_with_Fasting_Glucose_Body_Mass_Index_and_Energy_Expenditure"><img alt="Research paper thumbnail of SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure" class="work-thumbnail" src="https://attachments.academia-assets.com/108857982/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276751/SUN_585_Associations_Between_UCP1_rs1800592_UCP2_rs6593366_and_UCP3_rs1800849_with_Fasting_Glucose_Body_Mass_Index_and_Energy_Expenditure">SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure</a></div><div class="wp-workCard_item"><span>Journal of the Endocrine Society</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carrier superfamily and play an important role in energy homeostasis. UCP-1 is expressed mostly in brown adipose tissue (BAT) and act in the thermogenesis and regulation of energy expenditure. UCP-2 has a role in the metabolism of fatty acids direct and indirectly path insulin secretion. UCP-3 is specific of skeletal muscle and BAT and may affects the adaptive and translocation of fatty acids. Genetic polymorphisms in these proteins have been associated with obesity, as rs1800592 (-3826 A/G) in UCP-1 gene. The rs659366 (-866GA) UCP-2 has being associated with high expression of its RNAm, decrease of obesity risk, and increase of energy expenditure. The rs1800849 (-55CT) UCP-3 has been associated with low risk of type 2 Diabetes Mellitus, but its association with body mass index is controversial. Objective: To analyze the association of the polymorphisms rs1800592 UCP-1, rs659366 UCP-2, and rs...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d93addfaf9db9d77291f1a9f82cc83b9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108857982,"asset_id":111276751,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108857982/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276751"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276751"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276751; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276751]").text(description); $(".js-view-count[data-work-id=111276751]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276751; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276751']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276751, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d93addfaf9db9d77291f1a9f82cc83b9" } } $('.js-work-strip[data-work-id=111276751]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276751,"title":"SUN-585 Associations Between UCP1(rs1800592),UCP2(rs6593366) and UCP3(rs1800849) with Fasting Glucose, Body Mass Index, and Energy Expenditure","translated_title":"","metadata":{"abstract":"Background: The uncoupling proteins (UCPs) belong to the mitochondrial inner membrane anion carrier superfamily and play an important role in energy homeostasis. UCP-1 is expressed mostly in brown adipose tissue (BAT) and act in the thermogenesis and regulation of energy expenditure. UCP-2 has a role in the metabolism of fatty acids direct and indirectly path insulin secretion. UCP-3 is specific of skeletal muscle and BAT and may affects the adaptive and translocation of fatty acids. Genetic polymorphisms in these proteins have been associated with obesity, as rs1800592 (-3826 A/G) in UCP-1 gene. The rs659366 (-866GA) UCP-2 has being associated with high expression of its RNAm, decrease of obesity risk, and increase of energy expenditure. The rs1800849 (-55CT) UCP-3 has been associated with low risk of type 2 Diabetes Mellitus, but its association with body mass index is controversial. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276746"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111276746/Serum_IGFBP_1_Concentration_and_Its_Relation_to_Insulin_Leptin_Levels_Age_Duration_of_Sleep_and_Breastfeeding_in_Obese_Children"><img alt="Research paper thumbnail of Serum IGFBP-1 Concentration and Its Relation to Insulin, Leptin Levels, Age, Duration of Sleep and Breastfeeding in Obese Children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111276746/Serum_IGFBP_1_Concentration_and_Its_Relation_to_Insulin_Leptin_Levels_Age_Duration_of_Sleep_and_Breastfeeding_in_Obese_Children">Serum IGFBP-1 Concentration and Its Relation to Insulin, Leptin Levels, Age, Duration of Sleep and Breastfeeding in Obese Children</a></div><div class="wp-workCard_item"><span>The Endocrine Society's 93rd Annual Meeting & Expo, June 4–7, 2011 - Boston</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276746"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276746"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276746; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276745"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111276745/Ghrelin_and_GHSR1_receptor_in_placentas_of_SGA_LGA_and_AGA_newborns"><img alt="Research paper thumbnail of Ghrelin and GHSR1 receptor in placentas of SGA, LGA, and AGA newborns" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111276745/Ghrelin_and_GHSR1_receptor_in_placentas_of_SGA_LGA_and_AGA_newborns">Ghrelin and GHSR1 receptor in placentas of SGA, LGA, and AGA newborns</a></div><div class="wp-workCard_item"><span>Endocrine Abstracts</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276745"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276745"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276745; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276745]").text(description); $(".js-view-count[data-work-id=111276745]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276745; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276745']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276745, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276745]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276745,"title":"Ghrelin and GHSR1 receptor in placentas of SGA, LGA, and AGA newborns","translated_title":"","metadata":{"publisher":"Bioscientifica","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Endocrine Abstracts"},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276745/Ghrelin_and_GHSR1_receptor_in_placentas_of_SGA_LGA_and_AGA_newborns","translated_internal_url":"","created_at":"2023-12-12T16:40:40.255-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Ghrelin_and_GHSR1_receptor_in_placentas_of_SGA_LGA_and_AGA_newborns","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin"}],"urls":[{"id":36980203,"url":"http://www.endocrine-abstracts.org/ea/0037/ea0037GP.05.10.htm"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276744"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276744/_Risk_factors_of_the_complications_of_diabetes_mellitus_"><img alt="Research paper thumbnail of [Risk factors of the complications of diabetes mellitus]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276744/_Risk_factors_of_the_complications_of_diabetes_mellitus_">[Risk factors of the complications of diabetes mellitus]</a></div><div class="wp-workCard_item"><span>Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A total of 1,030 diabetic patients were studied in order to identify factors associated with vari...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276744"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276744"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276744; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276744]").text(description); $(".js-view-count[data-work-id=111276744]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276744; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276744']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276744, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276744]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276744,"title":"[Risk factors of the complications of diabetes mellitus]","translated_title":"","metadata":{"abstract":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...","publication_name":"Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición"},"translated_abstract":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...","internal_url":"https://www.academia.edu/111276744/_Risk_factors_of_the_complications_of_diabetes_mellitus_","translated_internal_url":"","created_at":"2023-12-12T16:40:40.143-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Risk_factors_of_the_complications_of_diabetes_mellitus_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"A total of 1,030 diabetic patients were studied in order to identify factors associated with various complications. A higher proportion of women was found (64.1%). Using regression analysis of prevalence versus the logarithm of the duration of diabetes, a half-life of 5.14 years was calculated. In the study of complications, peripheral neuropathy, amputations, renal impairment, albuminuria, myocardial infarction, cataract and amaurosis were strongly associated with duration of diabetes rather than with the age of the patient or the age at diagnosis; in contrast, blood pressure and impotence correlated better with the age of the patient. A discriminant function analysis permitted to identify several factors as predictors of diverse complication mainly: the duration of the disease, and previous use of insulin (negative correlation). Other predictors were glycemia, alcoholism, smoking habit and intake of legumes (beans). Albuminuria was assessed with a radioimmunoassay procedure and fo...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":63360,"name":"Discriminant Analysis","url":"https://www.academia.edu/Documents/in/Discriminant_Analysis"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":420633,"name":"Diabetes complications","url":"https://www.academia.edu/Documents/in/Diabetes_complications"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276743"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276743/Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study"><img alt="Research paper thumbnail of Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276743/Markers_of_the_progression_of_complications_in_patients_with_type_2_diabetes_a_one_year_longitudinal_study">Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study</a></div><div class="wp-workCard_item"><span>Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p&lt;0.0001) and eGFR decreased (p&lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p&lt;0.029)...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276743"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276743"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276743; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276743]").text(description); $(".js-view-count[data-work-id=111276743]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276743; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276743']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276743, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276743]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276743,"title":"Markers of the progression of complications in patients with type 2 diabetes: a one-year longitudinal study","translated_title":"","metadata":{"abstract":"Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p\u0026lt;0.029)...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Experimental and clinical endocrinology \u0026 diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association"},"translated_abstract":"Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. 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Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III). We measured glucose, lipids and HbA1c, low molecular weight AGEs (LMW AGEs), high sensitivity C-reactive protein (CRP), TNF-α, IL-6, and malondialdehyde (MDA). Patients were re-evaluated 1 year later.Patients were 52.2±6.8 years old with 11.0±4.9 years since diagnosis. After 1 year, circulating AGEs increased (p\u0026lt;0.0001) and eGFR decreased (p\u0026lt;0.0007) in groups II and III. IL-6 and MDA decreased in groups I and II. CRP (p\u0026lt;0.029)...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":3274,"name":"Gastroenterology","url":"https://www.academia.edu/Documents/in/Gastroenterology"},{"id":23243,"name":"Type 2 Diabetes","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":60979,"name":"Glycation","url":"https://www.academia.edu/Documents/in/Glycation"},{"id":63890,"name":"Complication","url":"https://www.academia.edu/Documents/in/Complication"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":96573,"name":"Diabetic Retinopathy","url":"https://www.academia.edu/Documents/in/Diabetic_Retinopathy"},{"id":227296,"name":"Microalbuminuria","url":"https://www.academia.edu/Documents/in/Microalbuminuria"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":261560,"name":"Nephropathy","url":"https://www.academia.edu/Documents/in/Nephropathy"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde"},{"id":1760562,"name":"Retinopathy","url":"https://www.academia.edu/Documents/in/Retinopathy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276742"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_"><img alt="Research paper thumbnail of [Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_">[Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]</a></div><div class="wp-workCard_item"><span>Ginecología y obstetricia de México</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Frequency an severity of physical and emotional symptoms in young female students from two cities...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276742"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276742"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276742; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276742]").text(description); $(".js-view-count[data-work-id=111276742]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276742; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276742']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276742, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276742]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276742,"title":"[Symptoms in adolescents in two Mexican cities and association with the menstrual cycle]","translated_title":"","metadata":{"abstract":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Ginecología y obstetricia de México"},"translated_abstract":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. An interview was carried out in 447 female adolescents, non seeking treatment, in a cross sectional design (146 from Guadalajara, and 301 from León). The mean age was 16.7 years (16.5 + SD 1.7 and 17.1 +/- 1.9 respectively). Most frequent symptoms for both groups were abdominal bloating, acne, increased appetite, low back pain, polydipsia, and emotional symptoms related to depression such as fatigue, desire to stay at home, desire to be alone and anxiety. Adolescents from Guadalajara reported increased intensity of diverse symptoms in comparison with adolescents from León: Breast tenderness, polydipsia and symptoms of depression. Difference was maintained after adjustment for covariates. In regards to the phase of the menstrual cycle, significantly different symptoms were: Abdominal bloating, breast tenderness, constipation, pru...","internal_url":"https://www.academia.edu/111276742/_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_","translated_internal_url":"","created_at":"2023-12-12T16:40:39.457-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Symptoms_in_adolescents_in_two_Mexican_cities_and_association_with_the_menstrual_cycle_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Frequency an severity of physical and emotional symptoms in young female students from two cities of México (a medium and a large sized city), were studied. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276741"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111276741/_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_"><img alt="Research paper thumbnail of [The relationship of the alimentary habits with standing height, weight and body surface area (author's transl)]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111276741/_The_relationship_of_the_alimentary_habits_with_standing_height_weight_and_body_surface_area_authors_transl_">[The relationship of the alimentary habits with standing height, weight and body surface area (author's transl)]</a></div><div class="wp-workCard_item"><span>Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276741"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276741"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276741; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276741]").text(description); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276740"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model"><img alt="Research paper thumbnail of Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model">Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate in a canine model the induction of tolerance to renal transplantation after splenecto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276740"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276740"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276740; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276740]").text(description); $(".js-view-count[data-work-id=111276740]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276740; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276740']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276740, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276740]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276740,"title":"Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model","translated_title":"","metadata":{"abstract":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","internal_url":"https://www.academia.edu/111276740/Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model","translated_internal_url":"","created_at":"2023-12-12T16:40:38.593-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Induction_of_Tolerance_in_Renal_Transplantation_Using_Splenic_Transplantation_Experimental_Study_in_a_Canine_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test). These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":58379,"name":"Renal transplantation","url":"https://www.academia.edu/Documents/in/Renal_transplantation"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":215075,"name":"Experimental Study","url":"https://www.academia.edu/Documents/in/Experimental_Study"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":894787,"name":"Immune Tolerance","url":"https://www.academia.edu/Documents/in/Immune_Tolerance"},{"id":1311261,"name":"Hemoglobins","url":"https://www.academia.edu/Documents/in/Hemoglobins"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3834134,"name":"leukocyte Count","url":"https://www.academia.edu/Documents/in/leukocyte_Count"}],"urls":[{"id":36980202,"url":"https://api.elsevier.com/content/article/PII:S0041134509017266?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276739"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria"><img alt="Research paper thumbnail of Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria">Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria</a></div><div class="wp-workCard_item"><span>Nephron</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes melli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276739"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276739"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276739; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276739]").text(description); $(".js-view-count[data-work-id=111276739]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276739; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276739']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276739, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276739]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276739,"title":"Renal Functional Reserve in Patients with Recently Diagnosed Type 2 Diabetes mellitus with and without Microalbuminuria","translated_title":"","metadata":{"abstract":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","publisher":"S. Karger AG","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Nephron"},"translated_abstract":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","internal_url":"https://www.academia.edu/111276739/Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria","translated_internal_url":"","created_at":"2023-12-12T16:40:38.375-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Renal_Functional_Reserve_in_Patients_with_Recently_Diagnosed_Type_2_Diabetes_mellitus_with_and_without_Microalbuminuria","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background/Aims: During the first 10 years, two thirds of the patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship with proteinuria and metabolic control are unknown at the early phases of disease. We investigated the frequency of MA in recently diagnosed type 2 DM patients, and its association with FRR. Methods: We studied 181 type 2 DM patients with less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) and renal plasma flow (ERPF) were evaluated before and after an acute oral protein load in 28 type 2 DM patients (14 with, and 14 without MA), and in 7 healthy subjects. Results: A total of 10.6% of the patients had MA. MA patients had higher cholesterol and triglyceride levels than those normoalbuminuric. Twenty recently diagnosed type 2 diabetic patients showed high basal GFR. Twelve of them had MA and insulin resistance. After the acute oral protein load, the control subjects a...","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71511,"name":"Diabetes 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class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276738/Age_at_Menopause_in_Women_with_Type_2_Diabetes_Mellitus">Age at Menopause in Women with Type 2 Diabetes Mellitus</a></div><div class="wp-workCard_item"><span>Menopause</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6872e169f99423d2a05a3229b401bb5d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858010,"asset_id":111276738,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858010/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action 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href="https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_"><img alt="Research paper thumbnail of Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_">Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276737"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276737"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276737; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276737]").text(description); $(".js-view-count[data-work-id=111276737]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276737; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276737']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276737, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111276737]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276737,"title":"Stimulation of Luteinizing Hormone-Releasing Hormone Release from Perifused Hypothalamic Fragments by Phospholipase A2*","translated_title":"","metadata":{"abstract":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","publisher":"The Endocrine Society","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Endocrinology"},"translated_abstract":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","internal_url":"https://www.academia.edu/111276737/Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_","translated_internal_url":"","created_at":"2023-12-12T16:40:37.895-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Stimulation_of_Luteinizing_Hormone_Releasing_Hormone_Release_from_Perifused_Hypothalamic_Fragments_by_Phospholipase_A2_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"LHRH release is dependent on the availability of calcium, and prostaglandin E2 is a potent releaser of LHRH. Therefore, we investigated the role of phospholipase A2 (PLA2) on the release of LHRH from the hypothalamus. Four rat hypothalami were perifused with Krebs-Ringer buffer, and after a 60-min preincubation period, PLA2 was applied during 10 min. The LHRH response was determined by RIA of 10-min fractions collected for the next 60 min. PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect. Indomethacin treatment increased rather than diminished the PLA2 stimulation. Perifusion with melittin, an activator of PLA2, also increased LHRH release. These results are interpreted as a demonstration that PLA2 has a role in the release of LHRH and that a different route of the cyclooxygenase may be involved besides the well known mediation of prostaglandin E2.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":95704,"name":"Hypothalamus","url":"https://www.academia.edu/Documents/in/Hypothalamus"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":445229,"name":"Gonadotropin Releasing Hormone","url":"https://www.academia.edu/Documents/in/Gonadotropin_Releasing_Hormone"},{"id":528223,"name":"phospholipases A2","url":"https://www.academia.edu/Documents/in/phospholipases_A2"},{"id":541937,"name":"Stimulation","url":"https://www.academia.edu/Documents/in/Stimulation"},{"id":669908,"name":"EGTA","url":"https://www.academia.edu/Documents/in/EGTA"},{"id":1130425,"name":"Luteinizing Hormone","url":"https://www.academia.edu/Documents/in/Luteinizing_Hormone"},{"id":1866509,"name":"Indomethacin","url":"https://www.academia.edu/Documents/in/Indomethacin"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[{"id":36980199,"url":"http://academic.oup.com/endo/article-pdf/121/4/1483/10668504/endo1483.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111276736"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus"><img alt="Research paper thumbnail of Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/108858019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus">Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus</a></div><div class="wp-workCard_item"><span>Diabetic Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalb...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec14e307ab3276cfd35e4879cf245f46" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108858019,"asset_id":111276736,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111276736"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111276736"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111276736; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111276736]").text(description); $(".js-view-count[data-work-id=111276736]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111276736; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111276736']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111276736, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ec14e307ab3276cfd35e4879cf245f46" } } $('.js-work-strip[data-work-id=111276736]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111276736,"title":"Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Diabetic Medicine","grobid_abstract_attachment_id":108858019},"translated_abstract":null,"internal_url":"https://www.academia.edu/111276736/Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus","translated_internal_url":"","created_at":"2023-12-12T16:40:37.664-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38338769,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108858019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858019/thumbnails/1.jpg","file_name":"j.1464-5491.2011.03380.x20231213-1-gnpjny.pdf","download_url":"https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_exercise_intensity_on_albuminu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858019/j.1464-5491.2011.03380.x20231213-1-gnpjny-libre.pdf?1702428631=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_exercise_intensity_on_albuminu.pdf\u0026Expires=1734023513\u0026Signature=f3I9iVXlBl3xNKqV5xIcjF1KWxiWszZAldGLADdJ504lumK4m5pjqvDwgSS~1D00PVYHR-wGiVLMf1w~e-aaH~nSDKdTKjMwt4X-7dpnyzeBnxCc~IXzfk9FL5EjxxaMwR93CSGbDT9dDSxM9HzsKatDAF9fpuh~y4BBfOOTfCKjukG2DdolUXMcpptls7RxCPoNjs7WT7403rAM7upHCHULTenWdiBWyGUxdgWMlrP2SaYQOE0mp6PHOCRy32RuwXClGUJhrXQUnnsw6-thrNBC8ansh7DUTmbIE-v9ZGHGSxV6mMkSNHjI0HOvQMNnyghSJjf8hftUbAUU8ghHRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_exercise_intensity_on_albuminuria_in_adolescents_with_Type_1_diabetes_mellitus","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 lg ⁄ min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.","owner":{"id":38338769,"first_name":"Juan","middle_initials":null,"last_name":"Malacara","page_name":"JuanMalacara","domain_name":"independent","created_at":"2015-11-14T15:33:20.407-08:00","display_name":"Juan Malacara","url":"https://independent.academia.edu/JuanMalacara"},"attachments":[{"id":108858019,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108858019/thumbnails/1.jpg","file_name":"j.1464-5491.2011.03380.x20231213-1-gnpjny.pdf","download_url":"https://www.academia.edu/attachments/108858019/download_file?st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&st=MTczNDAxOTkxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_exercise_intensity_on_albuminu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108858019/j.1464-5491.2011.03380.x20231213-1-gnpjny-libre.pdf?1702428631=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_exercise_intensity_on_albuminu.pdf\u0026Expires=1734023513\u0026Signature=f3I9iVXlBl3xNKqV5xIcjF1KWxiWszZAldGLADdJ504lumK4m5pjqvDwgSS~1D00PVYHR-wGiVLMf1w~e-aaH~nSDKdTKjMwt4X-7dpnyzeBnxCc~IXzfk9FL5EjxxaMwR93CSGbDT9dDSxM9HzsKatDAF9fpuh~y4BBfOOTfCKjukG2DdolUXMcpptls7RxCPoNjs7WT7403rAM7upHCHULTenWdiBWyGUxdgWMlrP2SaYQOE0mp6PHOCRy32RuwXClGUJhrXQUnnsw6-thrNBC8ansh7DUTmbIE-v9ZGHGSxV6mMkSNHjI0HOvQMNnyghSJjf8hftUbAUU8ghHRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography"},{"id":58497,"name":"Metabolic control analysis","url":"https://www.academia.edu/Documents/in/Metabolic_control_analysis"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":100336,"name":"Body Composition","url":"https://www.academia.edu/Documents/in/Body_Composition"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise"},{"id":149446,"name":"Diabetic","url":"https://www.academia.edu/Documents/in/Diabetic"},{"id":227296,"name":"Microalbuminuria","url":"https://www.academia.edu/Documents/in/Microalbuminuria"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":752559,"name":"Albuminuria","url":"https://www.academia.edu/Documents/in/Albuminuria"},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption"}],"urls":[{"id":36980198,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1464-5491.2011.03380.x/fullpdf"}]}, dispatcherData: dispatcherData }); 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