Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="fr"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link href="http://purl.org/dc/elements/1.1/" rel="schema.DC"> <meta name="citation_language" content="en" /> <meta name="DC.language" content="en" /> <meta name="DC.type" content="journal" /> <meta property="og:type" content="journal" /> <meta name="citation_title" content="Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study" /> <meta name="DC.title" content="Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study" /> <meta property="og:title" content="Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study" /> <meta name="DC.identifier" content="https://hal.science/hal-04815235" /> <meta name="DC.identifier" content="hal-04815235" /> <meta property="og:url" content="https://hal.science/hal-04815235" /> <meta name="citation_author" content="Pierluigi Banco" /> <meta name="citation_author_institution" content="[GIN] Grenoble Institut des Neurosciences" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="DC.creator" content="Pierluigi Banco" /> <meta name="citation_author" content="Fabio Silvio Taccone" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire Brugmann [Bruxelles]" /> <meta name="citation_author_institution" content="Université libre de Bruxelles" /> <meta name="DC.creator" content="Fabio Silvio Taccone" /> <meta name="citation_author" content="Dimitri Sourd" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="citation_author_institution" content="Université Grenoble Alpes" /> <meta name="DC.creator" content="Dimitri Sourd" /> <meta name="citation_author" content="Claudio Privitera" /> <meta name="citation_author_institution" content="University of California [Berkeley]" /> <meta name="DC.creator" content="Claudio Privitera" /> <meta name="citation_author" content="Jean-Luc Bosson" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="citation_author_institution" content="Université Grenoble Alpes" /> <meta name="DC.creator" content="Jean-Luc Bosson" /> <meta name="citation_author" content="Thomas Luz Teixeira" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire Brugmann [Bruxelles]" /> <meta name="citation_author_institution" content="Université libre de Bruxelles" /> <meta name="DC.creator" content="Thomas Luz Teixeira" /> <meta name="citation_author" content="Anais Adolle" /> <meta name="citation_author_institution" content="[GIN] Grenoble Institut des Neurosciences" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="DC.creator" content="Anais Adolle" /> <meta name="citation_author" content="Jean-François Payen" /> <meta name="citation_author_institution" content="[GIN] Grenoble Institut des Neurosciences" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="DC.creator" content="Jean-François Payen" /> <meta name="citation_author" content="Pierre Bouzat" /> <meta name="citation_author_institution" content="[GIN] Grenoble Institut des Neurosciences" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="DC.creator" content="Pierre Bouzat" /> <meta name="citation_author" content="Tobias Gauss" /> <meta name="citation_author_institution" content="[GIN] Grenoble Institut des Neurosciences" /> <meta name="citation_author_institution" content="Centre Hospitalier Universitaire [CHU Grenoble]" /> <meta name="DC.creator" content="Tobias Gauss" /> <meta name="citation_abstract" content="PURPOSE : This pilot study aimed to determine the capacity of automated infrared pupillometry (AIP) alone and in combination with transcranial doppler (TCD) on admission to rule out need for intense neuroAQ2 critical care (INCC) in severe traumatic brain injury (TBI). METHODS : In this observational pilot study clinicians performed AIP and TCD measurements on admission in blunt TBI patients with a Glasgow Coma Score (GCS) &lt; 9 and/or motor score &lt; 6. A Neurological Pupil index (NPi) &lt; 3, Pulsatility Index (PI) &gt; 1,4 or diastolic blood flow velocity (dV) of &lt; 20 cm/s were used to rule out the need for INCC (exceeding the tier 0 Seattle Consensus Conference). The primary outcome was the negative likelihood ratio (nLR) of NPi &lt; 3 alone or in combination with TCD to detect need for INCC. RESULTS : A total of 69 TBI patients were included from May 2019 to September 2020. Of those, 52/69 (75%) median age was 45 [28-67], median prehospital GCS of 7 [5-8], median Injury Severity Scale of 13.0 [6.5-25.5], median Marshall Score of 4 [3-5], the median Glasgow Outcome Scale at discharge was 3 [1-5]. NPi &lt; 3 was an independent predictor of INCC. NPi demonstrated a nLR of 0,6 (95%CI 0.4-0.9; AUROC, 0.65, 95% CI 0.51-0.79), a combination of NPi and TCD showed a nLR of 0.6 (95% CI 0.4-1.0; AUROC 0.67 95% CI 0.52-0.83) to predict INCC. CONCLUSION : This pilot study suggests a possible useful contribution of NPi to determine the need for INCC in severe blunt TBI patients on admission. © 2024. The Author(s)." /> <meta name="DC.description" content="PURPOSE : This pilot study aimed to determine the capacity of automated infrared pupillometry (AIP) alone and in combination with transcranial doppler (TCD) on admission to rule out need for intense neuroAQ2 critical care (INCC) in severe traumatic brain injury (TBI). METHODS : In this observational pilot study clinicians performed AIP and TCD measurements on admission in blunt TBI patients with a Glasgow Coma Score (GCS) &lt; 9 and/or motor score &lt; 6. A Neurological Pupil index (NPi) &lt; 3, Pulsatility Index (PI) &gt; 1,4 or diastolic blood flow velocity (dV) of &lt; 20 cm/s were used to rule out the need for INCC (exceeding the tier 0 Seattle Consensus Conference). The primary outcome was the negative likelihood ratio (nLR) of NPi &lt; 3 alone or in combination with TCD to detect need for INCC. RESULTS : A total of 69 TBI patients were included from May 2019 to September 2020. Of those, 52/69 (75%) median age was 45 [28-67], median prehospital GCS of 7 [5-8], median Injury Severity Scale of 13.0 [6.5-25.5], median Marshall Score of 4 [3-5], the median Glasgow Outcome Scale at discharge was 3 [1-5]. NPi &lt; 3 was an independent predictor of INCC. NPi demonstrated a nLR of 0,6 (95%CI 0.4-0.9; AUROC, 0.65, 95% CI 0.51-0.79), a combination of NPi and TCD showed a nLR of 0.6 (95% CI 0.4-1.0; AUROC 0.67 95% CI 0.52-0.83) to predict INCC. CONCLUSION : This pilot study suggests a possible useful contribution of NPi to determine the need for INCC in severe blunt TBI patients on admission. © 2024. The Author(s)." /> <meta name="description" content="PURPOSE : This pilot study aimed to determine the capacity of automated infrared pupillometry (AIP) alone and in combination with transcranial doppler (TCD) on admission to rule out need for intense neuroAQ2 critical care (INCC) in severe traumatic brain injury (TBI). METHODS : In this observational pilot study clinicians performed AIP and TCD measurements on admission in blunt TBI patients with a Glasgow Coma Score (GCS) &lt; 9 and/or motor score &lt; 6. A Neurological Pupil index (NPi) &lt; 3, Pulsatility Index (PI) &gt; 1,4 or diastolic blood flow velocity (dV) of &lt; 20 cm/s were used to rule out the need for INCC (exceeding the tier 0 Seattle Consensus Conference). The primary outcome was the negative likelihood ratio (nLR) of NPi &lt; 3 alone or in combination with TCD to detect need for INCC. RESULTS : A total of 69 TBI patients were included from May 2019 to September 2020. Of those, 52/69 (75%) median age was 45 [28-67], median prehospital GCS of 7 [5-8], median Injury Severity Scale of 13.0 [6.5-25.5], median Marshall Score of 4 [3-5], the median Glasgow Outcome Scale at discharge was 3 [1-5]. NPi &lt; 3 was an independent predictor of INCC. NPi demonstrated a nLR of 0,6 (95%CI 0.4-0.9; AUROC, 0.65, 95% CI 0.51-0.79), a combination of NPi and TCD showed a nLR of 0.6 (95% CI 0.4-1.0; AUROC 0.67 95% CI 0.52-0.83) to predict INCC. CONCLUSION : This pilot study suggests a possible useful contribution of NPi to determine the need for INCC in severe blunt TBI patients on admission. © 2024. The Author(s)." /> <meta property="og:description" content="PURPOSE : This pilot study aimed to determine the capacity of automated infrared pupillometry (AIP) alone and in combination with transcranial doppler (TCD) on admission to rule out need for intense neuroAQ2 critical care (INCC) in severe traumatic brain injury (TBI). METHODS : In this observational pilot study clinicians performed AIP and TCD measurements on admission in blunt TBI patients with a Glasgow Coma Score (GCS) &lt; 9 and/or motor score &lt; 6. A Neurological Pupil index (NPi) &lt; 3, Pulsatility Index (PI) &gt; 1,4 or diastolic blood flow velocity (dV) of &lt; 20 cm/s were used to rule out the need for INCC (exceeding the tier 0 Seattle Consensus Conference). The primary outcome was the negative likelihood ratio (nLR) of NPi &lt; 3 alone or in combination with TCD to detect need for INCC. RESULTS : A total of 69 TBI patients were included from May 2019 to September 2020. Of those, 52/69 (75%) median age was 45 [28-67], median prehospital GCS of 7 [5-8], median Injury Severity Scale of 13.0 [6.5-25.5], median Marshall Score of 4 [3-5], the median Glasgow Outcome Scale at discharge was 3 [1-5]. NPi &lt; 3 was an independent predictor of INCC. NPi demonstrated a nLR of 0,6 (95%CI 0.4-0.9; AUROC, 0.65, 95% CI 0.51-0.79), a combination of NPi and TCD showed a nLR of 0.6 (95% CI 0.4-1.0; AUROC 0.67 95% CI 0.52-0.83) to predict INCC. CONCLUSION : This pilot study suggests a possible useful contribution of NPi to determine the need for INCC in severe blunt TBI patients on admission. © 2024. The Author(s)." /> <meta name="citation_keywords" content="Traumatic brain injury;Neurocritical care;Transcranial doppler;Pupillometry" /> <meta name="DC.subject" content="Traumatic brain injury;Neurocritical care;Transcranial doppler;Pupillometry" /> <meta name="keywords" content="Traumatic brain injury;Neurocritical care;Transcranial doppler;Pupillometry" /> <meta name="citation_pdf_url" content="https://hal.science/hal-04815235/document" /> <meta name="DC.identifier" content="https://hal.science/hal-04815235/document" /> <meta property="og:url" content="https://hal.science/hal-04815235/document" /> <meta name="citation_online_date" content="2024/12/02" /> <meta name="citation_publication_date" content="2024" /> <meta name="DC.date" content="2024" /> <meta name="DC.issued" content="2024" /> <meta name="citation_firstpage" content="1209–1217" /> <meta name="citation_journal_title" content="European Journal of Trauma and Emergency Surgery" /> <meta name="DC.relation.ispartof" content="European Journal of Trauma and Emergency Surgery" /> <meta name="citation_issue" content="4" /> <meta name="DC.citation.issue" content="4" /> <meta name="citation_volume" content="50" /> <meta name="DC.citation.volume" content="50" /> <meta name="citation_doi" content="10.1007/s00068-023-02435-1" /> <meta name="citation_pmid" content="38226989" /> <meta name="citation_id" content="PMC11458749" /> <link rel='http://www.w3.org/ns/ldp#inbox' href="https://inbox.hal.science/" /> <link href="//cdn.mathjax.org" rel="dns-prefetch" > <link rel="apple-touch-icon" sizes="180x180" href="/assets/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="/assets/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="/assets/favicon/favicon-16x16.png"> <link rel="manifest" href="/assets/site.webmanifest"> <link rel="mask-icon" href="/assets/favicon/safari-pinned-tab.svg" color="#000092"> <meta name="msapplication-TileColor" content="#000092"> <meta name="theme-color" content="#ffffff"> <link rel="stylesheet" href="/assets/build/main.abf14aee.css" /> <link href="https://cdnjs.cloudflare.com/ajax/libs/select2/4.0.13/css/select2.min.css" rel="stylesheet"> <link href="/assets/css/select2totree.css" rel="stylesheet"> <link rel="stylesheet" href="/public/style.ng.css?1674236289" /> <script src="/assets/js/translations.php?lang=fr"></script> <script src="/assets/build/runtime.763fa2e6.js"></script> <script src="/assets/build/main.a146c055.js"></script> <script src="//cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js?config=TeX-AMS-MML_HTMLorMML" async></script> <script type='text/x-mathjax-config'>MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['$$','$$']]}});</script><script src="https://cdnjs.cloudflare.com/ajax/libs/select2/4.0.13/js/select2.min.js"></script> <script src="/assets/js/select2totree.js"></script> <script src="/static/js/tarteaucitron/tarteaucitron.js"></script> <script src="/static/js/tarteaucitron4hal/tarteaucitron.servicesHAL.js"></script> <script type="text/javascript"> tarteaucitron.init({ "privacyUrl": "", /* Privacy policy url */ "hashtag": "#tarteaucitron", /* Open the panel with this hashtag */ "cookieName": "tarteaucitron", /* Cookie name */ "orientation": "top", /* Banner position (top - bottom) */ "showAlertSmall": true, /* Show the small banner on bottom right */ "cookieslist": true, /* Show the cookie list */ "adblocker": false, /* Show a Warning if an adblocker is detected */ "AcceptAllCta" : true, /* Show the accept all button when highPrivacy on */ "highPrivacy": false, /* Disable auto consent */ "handleBrowserDNTRequest": false, /* If Do Not Track == 1, disallow all */ "removeCredit": false, /* Remove credit link */ "moreInfoLink": true, /* Show more info link */ "useExternalCss": false, /* If false, the tarteaucitron.css file will be loaded */ "cookieDomain": "hal.science", /* Shared cookie for multisite */ "readmoreLink": "/cookiespolicy", /* Change the default readmore link */ "closePopup": false, "showIcon": false, // Ne pas mettre showAlertSmall et showIcon a true en meme temps "DenyAllCta" : true, }); 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href='javascript:void(0);' onclick="LangInit(this, 'qa');">Titre de l'ouvrage</a></li><li class='dropdown-item'><a data-val='serie_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Titre du volume (Série)</a></li><li class='dropdown-item'><a data-val='text_fulltext' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Champ de recherche par défaut (multicritères) + texte intégral des PDF</a></li><li class='dropdown-item'><a data-val='abstract_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Résumé</a></li><li class='dropdown-item'><a data-val='fulltext_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Texte intégral indexé des documents PDF</a></li><li class='dropdown-item'><a data-val='keyword_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Mots-clés</a></li><li class='dropdown-item'><a data-val='docType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Type de document</a></li><li class='dropdown-item'><a data-val='docSubType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-type de document</a></li><li class='dropdown-item'><a data-val='identifiers_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Tous les identifiants du document</a></li><li class='dropdown-item'><a data-val='halId_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Identifiant HAL du dépôt</a></li><li class='dropdown-item'><a data-val='language_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Langue du document (texte)</a></li><li class='dropdown-item'><a data-val='country_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Pays (Texte)</a></li><li class='dropdown-item'><a data-val='city_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Ville</a></li><li class='dropdown-item'><a data-val='inPress_bool' href='javascript:void(0);' onclick="LangInit(this, 'qa');">À paraître (true ou false)</a></li></ul> <input type="text" name="qa[title_t][]" id="document" value="" class="input-flex form-control input-sm" lang="title_t" aria-describedby="document-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="author-element"><label for="author" class="col-md-3 control-label optional">Auteur</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='auth_t'>Auteur (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='auth_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur (multicritères)</a></li><li class='dropdown-item'><a data-val='authFullName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Nom complet</a></li><li class='dropdown-item'><a data-val='authLastName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Nom de famille</a></li><li class='dropdown-item'><a data-val='authFirstName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Prénom</a></li><li class='dropdown-item'><a data-val='authMiddleName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Complément de nom, deuxième prénom</a></li><li class='dropdown-item'><a data-val='authOrganism_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Organisme payeur</a></li><li class='dropdown-item'><a data-val='authIdHal_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : IdHal (chaîne de caractères)</a></li><li class='dropdown-item'><a data-val='authQuality_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Fonction</a></li><li class='dropdown-item'><a data-val='authIdHal_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : personID (entier)</a></li><li class='dropdown-item'><a data-val='authOrganismId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Identifiant de l'organisme payeur</a></li><li class='dropdown-item'><a data-val='authStructId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Identifiant de la structure</a></li><li class='dropdown-item'><a data-val='director_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Directeur de thèse</a></li><li class='dropdown-item'><a data-val='publisher_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur</a></li><li class='dropdown-item'><a data-val='scientificEditor_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur scientifique</a></li><li class='dropdown-item'><a data-val='seriesEditor_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur de la série</a></li></ul> <input type="text" name="qa[auth_t][]" id="author" value="" class="input-flex form-control input-sm" lang="auth_t" aria-describedby="author-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="structure-element"><label for="structure" class="col-md-3 control-label optional">Structure</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='structure_t'>Structure (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='structure_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure (multicritères)</a></li><li class='dropdown-item'><a data-val='structAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Acronyme</a></li><li class='dropdown-item'><a data-val='structName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Nom</a></li><li class='dropdown-item'><a data-val='structCode_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Code</a></li><li class='dropdown-item'><a data-val='structCountry_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Pays</a></li><li class='dropdown-item'><a data-val='structType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Type</a></li><li class='dropdown-item'><a data-val='structValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='structId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Identifiant HAL de la structure</a></li><li class='dropdown-item'><a data-val='rteamStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/équipe de recherche : Pays</a></li><li class='dropdown-item'><a data-val='deptStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement d'équipes : Pays</a></li><li class='dropdown-item'><a data-val='labStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/laboratoire : Pays</a></li><li class='dropdown-item'><a data-val='rgrpLabStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement de laboratoires : Pays</a></li><li class='dropdown-item'><a data-val='instStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/institution : Pays</a></li><li class='dropdown-item'><a data-val='rgrpInstStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement d'institutions : Pays</a></li></ul> <input type="text" name="qa[structure_t][]" id="structure" value="" class="input-flex form-control input-sm" lang="structure_t" aria-describedby="structure-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="qa-element"><label for="qa" class="col-md-3 control-label optional">Autres</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='text'>Champ de recherche par défaut (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='text' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Champ de recherche par défaut (multicritères)</a></li><li class='dropdown-item'><a data-val='--sep1' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='journal_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revues (multicritères)</a></li><li class='dropdown-item'><a data-val='journalPublisher_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Éditeur</a></li><li class='dropdown-item'><a data-val='journalTitleAbbr_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Titre abrégé</a></li><li class='dropdown-item'><a data-val='journalTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Titre</a></li><li class='dropdown-item'><a data-val='journalId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Identifiant interne</a></li><li class='dropdown-item'><a data-val='journalDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Date de début de publication</a></li><li class='dropdown-item'><a data-val='journalEissn_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : ISSN électronique</a></li><li class='dropdown-item'><a data-val='journalIssn_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : ISSN</a></li><li class='dropdown-item'><a data-val='journalPublisher_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Éditeur</a></li><li class='dropdown-item'><a data-val='journalSherpaColor_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Couleur dans SHERPA/RoMEO</a></li><li class='dropdown-item'><a data-val='journalValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='--sep2' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='conference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque (multicritères)</a></li><li class='dropdown-item'><a data-val='conferenceTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : Titre</a></li><li class='dropdown-item'><a data-val='conferenceOrganizer_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : Organisateur</a></li><li class='dropdown-item'><a data-val='conferenceStartDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : date de début (Année)</a></li><li class='dropdown-item'><a data-val='conferenceEndDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : date de fin (Année)</a></li><li class='dropdown-item'><a data-val='invitedCommunication_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Conférence invitée (oui/non)</a></li><li class='dropdown-item'><a data-val='--sep3' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='anrProject_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projets ANR (multicritères)</a></li><li class='dropdown-item'><a data-val='anrProjectAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Acronyme</a></li><li class='dropdown-item'><a data-val='anrProjectAcronymProgram_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Acronyme du programme</a></li><li class='dropdown-item'><a data-val='anrProjectReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Code décision (référence)</a></li><li class='dropdown-item'><a data-val='anrProjectTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Nom</a></li><li class='dropdown-item'><a data-val='anrProjectId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Identifiant interne</a></li><li class='dropdown-item'><a data-val='anrProjectValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='funding_acronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANSES: Acronyme</a></li><li class='dropdown-item'><a data-val='funding_reference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANSES: Code decision (reference)</a></li><li class='dropdown-item'><a data-val='funding_title_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANSES: Nom</a></li><li class='dropdown-item'><a data-val='ademe_funding_acronym_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ADEME: Acronyme</a></li><li class='dropdown-item'><a data-val='ademe_funding_reference_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ADEME: Code decision (reference)</a></li><li class='dropdown-item'><a data-val='ademe_funding_title_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ADEME: Nom</a></li><li class='dropdown-item'><a data-val='--sep4' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='europeanProject_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projets européens (multicritères)</a></li><li class='dropdown-item'><a data-val='europeanProjectAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Acronyme</a></li><li class='dropdown-item'><a data-val='europeanProjectCallId_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Identifiant de l'appel à projet</a></li><li class='dropdown-item'><a data-val='europeanProjectReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Référence</a></li><li class='dropdown-item'><a data-val='europeanProjectTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Nom</a></li><li class='dropdown-item'><a data-val='europeanProjectEndDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Date de fin</a></li><li class='dropdown-item'><a data-val='europeanProjectFinancing_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Financement</a></li><li class='dropdown-item'><a data-val='europeanProjectStartDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Date de début</a></li><li class='dropdown-item'><a data-val='europeanProjectValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='europeanProjectId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Identifiant interne</a></li><li class='dropdown-item'><a data-val='--sep6' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='producedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de production : année</a></li><li class='dropdown-item'><a data-val='releasedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de mise en ligne : année</a></li><li class='dropdown-item'><a data-val='publicationDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de publication : année</a></li><li class='dropdown-item'><a data-val='writingDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date d'écriture : année</a></li><li class='dropdown-item'><a data-val='modifiedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de modification du dépôt : année</a></li><li class='dropdown-item'><a data-val='submittedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de dépôt : année</a></li><li class='dropdown-item'><a data-val='ePublicationDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de publication électronique : année</a></li><li class='dropdown-item'><a data-val='--sep7' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='collection_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL (multicritères)</a></li><li class='dropdown-item'><a data-val='collCategory_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : catégorie</a></li><li class='dropdown-item'><a data-val='collCode_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Code</a></li><li class='dropdown-item'><a data-val='collName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Nom</a></li><li class='dropdown-item'><a data-val='collId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Identifiant interne</a></li><li class='dropdown-item'><a data-val='--sep8' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='contributorId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Identifiant interne du contributeur/déposant</a></li><li class='dropdown-item'><a data-val='contributorFullName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Nom complet du contributeur/déposant</a></li><li class='dropdown-item'><a data-val='--sep9' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='domain_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaines</a></li><li class='dropdown-item'><a data-val='primaryDomain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaine primaire</a></li><li class='dropdown-item'><a data-val='level0_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaine racine</a></li><li class='dropdown-item'><a data-val='level1_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 1</a></li><li class='dropdown-item'><a data-val='level2_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 2</a></li><li class='dropdown-item'><a data-val='level3_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 3</a></li><li class='dropdown-item'><a data-val='--sep10' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='status_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Statut du document</a></li><li class='dropdown-item'><a data-val='version_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Version du document</a></li><li class='dropdown-item'><a data-val='submitType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Type de dépôt</a></li><li class='dropdown-item'><a data-val='docType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Type de document</a></li><li class='dropdown-item'><a data-val='isbn_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">ISBN</a></li><li class='dropdown-item'><a data-val='number_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Numéro - référence</a></li><li class='dropdown-item'><a data-val='doiId_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Identifiant DOI</a></li><li class='dropdown-item'><a data-val='--sep11' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='classification_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Classification</a></li><li class='dropdown-item'><a data-val='audience_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Audience</a></li><li class='dropdown-item'><a data-val='popularLevel_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Vulgarisation</a></li><li class='dropdown-item'><a data-val='peerReviewing_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Comité de lecture - texte (oui ou non)</a></li><li class='dropdown-item'><a data-val='proceedings_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Actes de colloque</a></li><li class='dropdown-item'><a data-val='localReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Référence interne</a></li><li class='dropdown-item'><a data-val='funding_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Financement</a></li><li class='dropdown-item'><a data-val='collaboration_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collaborations</a></li></ul> <input type="text" name="qa[text][]" id="qa" value="" lang="text" class=" form-control input-sm" aria-describedby="qa-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <dt id="submit-label"> </dt><dd id="submit-element"> <button name="submit" id="submit-button" type="submit" value=" Lancer la recherche" class="btn btn-lg btnSearch hal-visualize-button" aria-describedby="submit-button-error"> Lancer la recherche</button></dd></form> <div class="mt-3"> <button class="tools-color btn-hide-show" data-selectOne="#solrSearchHeader" data-selectTwo="#advSearchHeader"> <span>Recherche experte (SolR)</span> </button> </div> </div> <div id="solrSearchHeader" class="hide"> <h3> Recherche experte (SolR)</h3> <form action="/search/index" method="get" id="searchHeaderSolr" name="search-simple" role="search"> <textarea type="text" name="q" class="p-5" autocomplete="off" cols="150" placeholder="Chercher un document, un auteur, un mot clef..." value=""></textarea> <div> <button type="submit" aria-label="Rechercher" class="hal-visualize-button"> <span class="icon-search" aria-hidden="true"></span> <span>Lancer la recherche</span> </button> </div> </form> <div class="mt-3"> <button class="tools-color btn-hide-show" data-selectOne="#solrSearchHeader" data-selectTwo="#advSearchHeader"> <span>Vers la recherche avancée</span> </button> </div> </div> </div> </div> </li> <li id="ssheader-submit" class="btn-primary-orange position-relative"> <a href="/submit/index" class="btn-hal hal-submit-button btn-primary-orange stretched-link"> <span class="icon-add colo-white" aria-hidden="true"></span> <span> Déposer </span> </a> </li> </ul> 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Surgery</span> <span class="year strong">Année : 2024</span> </div> <div class="section-content section-shadow"> <div style="display: flex; justify-content: space-between;"> <div style="display: flex; align-items: center;"> <h2 class="title-lang en active" lang="en" style="margin-bottom: 0;">Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study</h2> </div> <div> <span style="margin-left: 2%; margin-right: 3%"></span> </div> </div> <span></span> <div id="authors-simplified"> <div class="authors"> <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a href="/search/index/q/*/authFullName_s/Pierluigi+Banco" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Pierluigi Banco</span> </a> (1, 2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/561087">Centre Hospitalier Universitaire Brugmann [Bruxelles]</a> <a class='popover-affil' href="/search/index/q/*/structId_i/303388">Université libre de Bruxelles</a> <a href="/search/index/q/*/authFullName_s/Fabio+Silvio+Taccone" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Fabio Silvio Taccone</span> </a> (3, 4) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a class='popover-affil' href="/search/index/q/*/structId_i/1042703">Université Grenoble Alpes</a> <a href="/search/index/q/*/authFullName_s/Dimitri+Sourd" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Dimitri Sourd</span> </a> (2, 5) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/563719">University of California [Berkeley]</a> <a href="/search/index/q/*/authFullName_s/Claudio+Privitera" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Claudio Privitera</span> </a> (6) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1349988</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-0967-6026" title="ORCID" target="_blank">0000-0003-0967-6026</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a class='popover-affil' href="/search/index/q/*/structId_i/1042703">Université Grenoble Alpes</a> <a href="/search/index/q/*/authIdHal_i/1349988" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Jean-Luc Bosson</span> </a> (2, 5) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/561087">Centre Hospitalier Universitaire Brugmann [Bruxelles]</a> <a class='popover-affil' href="/search/index/q/*/structId_i/303388">Université libre de Bruxelles</a> <a href="/search/index/q/*/authFullName_s/Thomas+Luz+Teixeira" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Thomas Luz Teixeira</span> </a> (3, 4) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a href="/search/index/q/*/authFullName_s/Anais+Adolle" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Anais Adolle</span> </a> (1, 2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1331241</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0001-8400-3839" title="ORCID" target="_blank">0000-0001-8400-3839</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a href="/search/index/q/*/authIdHal_i/1331241" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Jean-François Payen</span> </a> (1, 2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>761435</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4667-6738" title="ORCID" target="_blank">0000-0003-4667-6738</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/137287534" title="IdRef" target="_blank">137287534</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a href="/search/index/q/*/authIdHal_i/761435" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Pierre Bouzat</span> </a> (1, 2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> <a class='popover-affil' href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> <a href="/search/index/q/*/authFullName_s/Tobias+Gauss" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>Tobias Gauss</span> </a> (1, 2) </div> <button type="button" class="btn btn-hide-show" data-selectOne="#authors-simplified" data-selectTwo="#authors-detailed">Afficher plus de détails</button> <div class="structures bg-beige"> <div> <span class="icon-institution" aria-hidden="true"></span> </div> <div> <span>1</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/408885' target='_blank'>GIN - [GIN] Grenoble Institut des Neurosciences</a><small> (Site Santé - Bâtiment Edmond J. Safra - Chemin Fortuné Ferrini 38706 La Tronche Cedex - France)</small> <label class='label label-primary label-VALID'>408885</label><ul><li><a href='/search/index/q/*/structId_i/303623' target='_blank'>INSERM - Institut National de la Santé et de la Recherche Médicale</a> : U1216<small> (101, rue de Tolbiac, 75013 Paris - France)</small> <label class='label label-primary label-VALID'>303623</label></li><li><a href='/search/index/q/*/structId_i/1042703' target='_blank'>UGA - Université Grenoble Alpes</a><small> (Adresse CS 40700 - 38058 Grenoble cedex - France)</small> <label class='label label-primary label-VALID'>1042703</label></li></ul></div>"> GIN - [GIN] Grenoble Institut des Neurosciences </a> <br> <span>2</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/257328' target='_blank'>CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]</a><small> (CS 10217 38043 Grenoble cedex 9 - France)</small> <label class='label label-primary label-VALID'>257328</label></div>"> CHUGA - Centre Hospitalier Universitaire [CHU Grenoble] </a> <br> <span>3</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/561087' target='_blank'>CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles]</a><small> (Place A.Van Gehuchten 4, 1020 Bruxelles - Belgique)</small> <label class='label label-primary label-VALID'>561087</label></div>"> CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles] </a> <br> <span>4</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/303388' target='_blank'>ULB - Université libre de Bruxelles</a><small> (Avenue Franklin Roosevelt 50 - 1050 Bruxelles - Belgique)</small> <label class='label label-primary label-VALID'>303388</label></div>"> ULB - Université libre de Bruxelles </a> <br> <span>5</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/1042703' target='_blank'>UGA - Université Grenoble Alpes</a><small> (Adresse CS 40700 - 38058 Grenoble cedex - France)</small> <label class='label label-primary label-VALID'>1042703</label></div>"> UGA - Université Grenoble Alpes </a> <br> <span>6</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/563719' target='_blank'>UC Berkeley - University of California [Berkeley]</a><small> (Berkeley, CA - États-Unis)</small> <label class='label label-primary label-VALID'>563719</label><ul><li><a href='/search/index/q/*/structId_i/471291' target='_blank'>UC - University of California</a><small> (États-Unis)</small> <label class='label label-primary label-VALID'>471291</label></li></ul></div>"> UC Berkeley - University of California [Berkeley] </a> <br> </div> </div> </div> <div id="authors-detailed"> <div class="container"> <div class="row"> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Pierluigi+Banco" target="_blank">Pierluigi Banco</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Fabio+Silvio+Taccone" target="_blank">Fabio Silvio Taccone</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/561087">Centre Hospitalier Universitaire Brugmann [Bruxelles]</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/303388">Université libre de Bruxelles</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Dimitri+Sourd" target="_blank">Dimitri Sourd</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/1042703">Université Grenoble Alpes</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Claudio+Privitera" target="_blank">Claudio Privitera</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/563719">University of California [Berkeley]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_i/1349988" target="_blank">Jean-Luc Bosson</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1349988</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-0967-6026" title="ORCID" target="_blank">0000-0003-0967-6026</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/1042703">Université Grenoble Alpes</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Thomas+Luz+Teixeira" target="_blank">Thomas Luz Teixeira</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/561087">Centre Hospitalier Universitaire Brugmann [Bruxelles]</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/303388">Université libre de Bruxelles</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Anais+Adolle" target="_blank">Anais Adolle</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_i/1331241" target="_blank">Jean-François Payen</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1331241</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0001-8400-3839" title="ORCID" target="_blank">0000-0001-8400-3839</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_i/761435" target="_blank">Pierre Bouzat</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>761435</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4667-6738" title="ORCID" target="_blank">0000-0003-4667-6738</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/137287534" title="IdRef" target="_blank">137287534</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/Tobias+Gauss" target="_blank">Tobias Gauss</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/408885">[GIN] Grenoble Institut des Neurosciences</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/257328">Centre Hospitalier Universitaire [CHU Grenoble]</a> </div> </div> </div> </div> </div> <button type="button" class="btn btn-hide-show" data-selectOne="#authors-simplified" data-selectTwo="#authors-detailed" style="margin-top: 22px;">Réduire la vue détaillée</button> </div> <div class="row" style="width: 102%;"> <div class="abstract col-lg-7"> <div> <h4> Résumé </h4> <div class="btn-group" role="group" aria-label="Choix langues"> <button class="btn btn-lang-abstract active" aria-pressed="true" data-lang="en"> en </button> </div> </div> <div class="abstract-content active" lang="en"> PURPOSE : This pilot study aimed to determine the capacity of automated infrared pupillometry (AIP) alone and in combination with transcranial doppler (TCD) on admission to rule out need for intense neuroAQ2 critical care (INCC) in severe traumatic brain injury (TBI). METHODS : In this observational pilot study clinicians performed AIP and TCD measurements on admission in blunt TBI patients with a Glasgow Coma Score (GCS) < 9 and/or motor score < 6. A Neurological Pupil index (NPi) < 3, Pulsatility Index (PI) > 1,4 or diastolic blood flow velocity (dV) of < 20 cm/s were used to rule out the need for INCC (exceeding the tier 0 Seattle Consensus Conference). The primary outcome was the negative likelihood ratio (nLR) of NPi < 3 alone or in combination with TCD to detect need for INCC. RESULTS : A total of 69 TBI patients were included from May 2019 to September 2020. Of those, 52/69 (75%) median age was 45 [28-67], median prehospital GCS of 7 [5-8], median Injury Severity Scale of 13.0 [6.5-25.5], median Marshall Score of 4 [3-5], the median Glasgow Outcome Scale at discharge was 3 [1-5]. NPi < 3 was an independent predictor of INCC. NPi demonstrated a nLR of 0,6 (95%CI 0.4-0.9; AUROC, 0.65, 95% CI 0.51-0.79), a combination of NPi and TCD showed a nLR of 0.6 (95% CI 0.4-1.0; AUROC 0.67 95% CI 0.52-0.83) to predict INCC. CONCLUSION : This pilot study suggests a possible useful contribution of NPi to determine the need for INCC in severe blunt TBI patients on admission. © 2024. The Author(s). </div> </div> <div class="col-lg-5"> <div class="keywords"> <div> <h4> Mots clés </h4> <div class="btn-group" role="group" aria-label="Choix langues" style="align-items: unset;"> <button class="btn btn-lang-keywords active" aria-pressed="true" data-lang="en"> en </button> </div> <div class="keys-lang en active" data-lang="en"> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/Traumatic%20brain%20injury" target="_blank" rel="nofollow">Traumatic brain injury</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/Neurocritical%20care" target="_blank" rel="nofollow">Neurocritical care</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/Transcranial%20doppler" target="_blank" rel="nofollow">Transcranial doppler</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/Pupillometry" target="_blank" rel="nofollow">Pupillometry</a> </span> </div> </div> </div> <div class="domains"> <h4> Domaines </h4> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/level1_domain_s/sdv.neu" rel="nofollow" target="_blank">Neurosciences [q-bio.NC]</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/level2_domain_s/sdv.ib.ima" rel="nofollow" target="_blank">Imagerie</a> </span> </div> <button data-toggle="modal" data-docid="4815235" data-target="#metadatas_Modal" aria-expanded="false" aria-controls="metadatas_Modal" class="btn hal-option-button metadatas" style="margin-top: 48px; 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Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study. <i>European Journal of Trauma and Emergency Surgery</i>, 2024, 50 (4), pp.1209-1217. <a target="_blank" href="https://dx.doi.org/10.1007/s00068-023-02435-1">⟨10.1007/s00068-023-02435-1⟩</a>. <a target="_blank" href="https://hal.science/hal-04815235v1">⟨hal-04815235⟩</a> </div> </div> <div class="section-content section-shadow section-export"> <h3> Exporter</h3> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/bibtex" target="_blank" style="white-space: nowrap;">BibTeX</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/tei" target="_blank" style="white-space: nowrap;">XML-TEI</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/dc" target="_blank" style="white-space: nowrap;">Dublin Core</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/dcterms" target="_blank" style="white-space: nowrap;">DC Terms</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/endnote" target="_blank" style="white-space: nowrap;">EndNote</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04815235v1/datacite" target="_blank" style="white-space: nowrap;">DataCite</a> </span> </div> <div class="section-content section-shadow section-collection"> <h3> Collections</h3> <div> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/INSERM" target="_blank"> INSERM</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/UGA" target="_blank"> UGA</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/GRENOBLEINSTITUTNEUROSCIENCES" target="_blank"> GRENOBLEINSTITUTNEUROSCIENCES</a> </span> </div> </div> <div class="section-content section-shadow" id="metrics"> <div class="row"> <div class="metrics-views col-6"> <span> 34 </span> <span>Consultations</span> </div> <div class="metrics-views col-6"> <span> 9 </span> <span>Téléchargements</span> </div> </div> </div> <div class="section-content section-shadow section-collection"> <h3> Altmetric</h3> <script src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <div data-badge-details="right" data-badge-type="donut" data-hide-no-mentions="false" class="altmetric-embed" data-doi="10.1007/s00068-023-02435-1" ></div> </div> <div class="section-content section-shadow"> <h3> Partager</h3>   <div class="a2a_kit a2a_kit_size_32 a2a_default_style" > <a class="a2a_button_google_gmail"></a><span class="sr-only"> </span> <a class="a2a_button_mastodon"></a><span class="sr-only"> </span> <a class="a2a_button_facebook"></a><span class="sr-only"> </span> <a class="a2a_button_x"></a><span class="sr-only"> </span> <a class="a2a_button_linkedin"></a><span class="sr-only"> </span> <a class="a2a_dd" href="https://www.addtoany.com/share"></a><span class="sr-only"> More </span> </div>  <script async src="https://static.addtoany.com/menu/page.js"></script>  </div> </section> </section> <script type="text/javascript"> $(function () { linkifyElem ('.linkify'); 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Prediction of neurocritical care intensity through automated infrared pupillometry and transcranial doppler in blunt traumatic brain injury: the NOPE study - Archive ouverte HAL