CINXE.COM

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vessels from pre-existing vasculature. It is a normal process in growth and development and is required for the formation of arteries, veins, and capillaries in an embryo.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Targets</span></div> <div class="tab tab_4" data-tab="4" data-tabname="literature" id="pharm_tabs_literature"><span>Literature (2)</span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_sub_cats"><h3>Angiogenesis Target Files</h3><ul class="tile_column_1"><li><a href="/cell-biology/antiangiogenics" title="Browse products for Antiangiogenics">Antiangiogenics</a></li><li><a href="/pharmacology/egfr" title="Browse products for EGFR">EGFR</a></li><li><a href="/pharmacology/fgfr" title="Browse products for FGFR">FGFR</a></li><li><a href="/cell-biology/hypoxia-inducible-factors" title="Browse products for Hypoxia Inducible Factors (HIF)">Hypoxia Inducible Factors (HIF)</a></li></ul><ul class="tile_column_2"><li><a href="/pharmacology/matrix-metalloproteases" title="Browse products for Matrix Metalloproteases">Matrix Metalloproteases</a></li><li><a href="/pharmacology/pdgfr" title="Browse products for PDGFR">PDGFR</a></li><li><a href="/pharmacology/protein-kinase-g" title="Browse products for Protein Kinase G">Protein Kinase G</a></li><li><a href="/pharmacology/vegfr" title="Browse products for VEGFR">VEGFR</a></li></ul></div> <div class="pharm_long_desc"><h2>Countering Angiogenesis</h2> <p>Angiogenesis has become an important target for <a href='/research-area/cancer-research' title='Browse products for cancer research'>cancer research</a> with the recognition that it is one of the critical events necessary for cancer growth and <a href='/research-area/metastasis' title='Browse products for metastasis'>metastasis</a>. As a tumor develops, its size is limited by the diffusion of metabolites from existing blood vessels. Tumor angiogenesis, the growth of the new blood vessels, is essential for cancerous tumors to keep growing and spreading.</p> <p>As a tumor grows, cells at the center become starved of oxygen, inducing the expression of a transcription factor - hypoxia inducible factor-1 (HIF-1) - which upregulates the expression of a range of angiogenic factors. Growth factor signaling also initiates HIF-1 activity, pre-empting the need for growing cells to maintain oxygen homeostasis. As a result, HIF-1 itself has been isolated as a therapeutic target for <a href='/research-area/cancer-research' title='Browse products for cancer'>cancer</a>. More than a dozen different proteins, as well as several smaller molecules, have been identified as angiogenic meaning that they are released by tumors as signals for angiogenesis. Inhibitors of angiogenesis (antiangiogenics) are currently the focus of intense cancer research.</p> <p>The hypoxic environment of <a href='/research-area/arthritis-research' title='Browse products for arthritis'>arthritic</a> joints also encourages angiogenesis, which in turn generates new blood vessels to supply the expanded synovial tissue with nutrients.</p> <h2>Promoting Angiogenesis</h2> <p>As well as its detrimental effects in tumor growth and inflammatory disorders, the generation of new blood vessels is a vital process in the context of <a href='/research-area/stroke-research' title='Browse products for Stroke Research'>stroke</a>, <a href='/research-area/cardiovascular-system-research' title='Browse products for Cardiovascular Disease Research'>cardiovascular disease</a> and <a href='/research-area/diabetes-research' title='Browse products for Diabetes Research'>diabetes</a>. Many of the pathologies associated with diabetes, such diabetic neuropathy, reduced wound healing and diabetic ulcers, are caused by a reduced blood supply to the downstream tissue. Therefore, promoting angiogenesis in diabetic patients may represent an important strategy in reducing morbidity. Recent work using adenovirus-mediated transfer of VEGF<sub>165</sub> showed that promoting angiogenesis significantly accelerated wound healing.</p> <p>Promoting angiogenesis may also be beneficial in the treatment of myocardial ischemia and peripheral vascular disease. Increasing perfusion of downstream ischemic tissues using cytokines such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) has demonstrated beneficial effects in several animal models, yet the results of clinical trials to date have been disappointing. This may be related to comorbidities such as endothelial dysfunction or atherosclerosis that may blunt the proangiogenic effects of such interventions. Despite these potentially confounding effects, further research into promoting angiogenesis in patients with cardiovascular disease or diabetes may uncover novel and effective therapeutic strategies.</p></div> <div class="pharm_long_desc2"><hr> <h3>Tumor Vascularization</h3> <img src='https://resources.tocris.com/images/targets/angiogenesis-target.jpg' alt='Angiogenesis' style='max-width:100%; margin:20px 0 10px 0'> <p><strong>Figure showing angiogenesis steps in tumor vascularization.</strong></p> <p><em>Taken from the <a href='/literature/product-guides/angiogenesis-in-cancer' title='Request or download your copy today!'>Angiogenesis in Cancer Guide</a> Edition 1, 2024. Request or download your copy today!</em></p></div> </div> <div class="tab_content tab_2" data-tab="2"> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> <h3>Literature for Angiogenesis</h3><p>Tocris offers the following scientific literature for Angiogenesis to showcase our products. We invite you to request* your copy today!</p><p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p><hr/><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/837762.jpg" data-toggle="lightbox" data-title="Angiogenesis in Cancer Research Product Guide" data-footer="<a href='/literature/literature-request/837762' rel='nofollow' title='Request copy of the Angiogenesis in Cancer'>Request copy</a> or <a href='/literature/literature-request/p837762' rel='nofollow' title='Request PDF of the Angiogenesis in Cancer'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/837762.jpg" alt="Angiogenesis in Cancer Research Product Guide" class="img-fluid"></a></div> <h4>Angiogenesis in Cancer Research Product Guide</h4> <p>This product guide provides background information on angiogenesis in cancer and lists around 150 products for the study of the main angiogenesis therapeutic targets including:</p> <ul class='bullet_list'> <li>Growth Factors</li> <li>Transcription Factors</li> <li>Adhesion, Extracellular Matrix Remodeling</li> <li>Key Signaling Pathways</li> </ul> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/837762" rel="nofollow" title="Request copy of the Angiogenesis in Cancer Research Product Guide">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p837762" rel="nofollow" title="Request PDF of the Angiogenesis in Cancer Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/525564.jpg?v=2" data-toggle="lightbox" data-title="Angiogenesis in Cancer Poster" data-footer="<a href='/literature/literature-request/525564' rel='nofollow' title='Request copy of the Angiogenesis in Cancer'>Request copy</a> or <a class=' pdf-download' href='https://resources.tocris.com/pdfs/literature/posters/angiogenesis-cancer-2023-poster.pdf' download='https://resources.tocris.com/pdfs/literature/posters/angiogenesis-cancer-2023-poster.pdf' rel='nofollow' title='Download PDF of the Angiogenesis in Cancer' data-title='Angiogenesis in Cancer Poster'>Download PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/525564.jpg?v=2" alt="Angiogenesis in Cancer Poster" class="img-fluid"></a></div> <h4>Angiogenesis in Cancer Poster</h4> <p>This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets. </p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/525564" rel="nofollow" title="Request copy of the Angiogenesis in Cancer Poster">Request copy</a> </li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/angiogenesis-cancer-2023-poster.pdf" download="https://resources.tocris.com/pdfs/literature/posters/angiogenesis-cancer-2023-poster.pdf" rel="nofollow" target="_blank" title="Download PDF of the Angiogenesis in Cancer Poster" data-title="Angiogenesis in Cancer Poster">Download PDF<div class="lit_pdf"></div></a></li> <li><a class="btn btn-quinary" href="/literature/life-science-posters" title="View all Life Science Posters">View all Life Science Posters</a></li> </ul> </div></div> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br /> Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO</div> <div class="fp_featured_product"><a href="/products/bi-3231_8039">8039 | BI 3231</a><br /> Potent and selective hydroxysteroid 17尾 dehydrogenase 13 (HSD17B13) inhibitor</div> </div> </div> </div> <div class="distributor_region"></div> <div class="widget"> <div class="widget_title">Literature in this Area</div> <div class="widget_content carousel slide" id="ds_literature_scroller" data-ride="carousel" data-interval="8000">  <div class="carousel-inner"><div class="item active"><div class="highlight">Angiogenesis in Cancer Guide</div> <a href="/literature/product-guides/angiogenesis-in-cancer"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/837762.jpg" alt="Angiogenesis in Cancer Research Product Guide"></a><p class="small">This guide provides background information on angiogenesis in cancer, and highlights products that can be used for the main angiogenesis therapeutic targets.</p><a class="btn btn-quinary" href="/literature/literature-request/837762" rel="nofollow" title="Request copy of the Angiogenesis in Cancer Research Product Guide">Request copy</a><a class="btn btn-quinary request-pdf" 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