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The PARC | Patient Activation Research Community

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It involves conducting experiments and studies to assess different ways to prevent, diagnose, treat and understand disease and disease progression. The ultimate goal is to improve patient care and health outcomes.</div></div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></div><div _ngcontent-ng-c4141810494 class="lps-media-col"><img _ngcontent-ng-c4141810494 alt class="lps-img" src="https://images.ctfassets.net/w00vjamh48ql/2b4ax3VF9hWxB3PKtUoNeh/74f8c39805e02e8e15a7e72c6e7062cb/GettyImages-1434437996-automatedimagerenditionjpeg__1_.jpg" height="2650" width="4000"></div><!----></div></section><!----><!----><!----><!----></amg-landing-page-content><!----><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><section _ngcontent-ng-c4141810494 class="landing-page-section componentClass1"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-100" id="landing-page-id1"><!----><div _ngcontent-ng-c4141810494 class="lps-content"><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass1">Clinical Trial Research</h1><div _ngcontent-ng-c4141810494 class="lps-content contentClass1">Clinical trials are one type of research that looks at new ways to prevent, detect, or treat disease. Clinical trials can study:<br> <ul> <li>New investigational drugs or new combinations of drugs</li> <li>New ways of doing surgery</li> <li>New medical devices</li> <li>New ways to use existing treatments</li> <li>New ways to change behaviors to improve health</li> <li>New ways to improve the quality of life for people with acute or chronic illnesses.</li> </ul></div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><a _ngcontent-ng-c4141810494 id="layout-100-btn" class="lps-btn buttonClass1"> I’M INTERESTED </a><!----><!----></div></div></div></section><!----><!----><!----><!----><!----></amg-landing-page-content><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><!----><section _ngcontent-ng-c4141810494 class="landing-page-section componentClass2"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-5050" id="landing-page-id2"><div _ngcontent-ng-c4141810494 class="lps-text-col"><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass2"></h1><div _ngcontent-ng-c4141810494 class="lps-content contentClass2"><div> <h2>Goal of Clinical Trials</h2> The goal of clinical trials is to determine if these treatments, prevention, and behavior approaches are safe and effective. People take part in clinical trials for many reasons. Healthy volunteers say they take part to help others and to contribute to moving science forward. People with an illness or disease also take part to help others, but also to possibly receive the study drug and to have close monitoring from the clinical trial staff. Clinical trials offer hope for many people and a chance to help researchers find better treatments for others in the future. <br><br> Clinical trials are conducted in a series of steps called “phases” and each phase has a different purpose for answering different questions. </div></div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></div><div _ngcontent-ng-c4141810494 class="lps-media-col"><img _ngcontent-ng-c4141810494 alt class="lps-img" src="https://images.ctfassets.net/w00vjamh48ql/3nuN8FpmeLJSk2sb3YJEU5/d01488b0e4b8856fbc2172466730ef12/clinical_trials.jpg" height="2650" width="4000"></div><!----></div></section><!----><!----><!----><!----></amg-landing-page-content><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><!----><!----><!----><article _ngcontent-ng-c4141810494 class="landing-page-section componentClass3"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-multi"><section _ngcontent-ng-c4141810494 class="lps-col"><!----><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass3">Phase 1</h1><div _ngcontent-ng-c4141810494 class="contentClass3">Researchers test a study drug in a small group of people (20–80) for the first time. The purpose is to study the drug to learn about safety and identify side effects.</div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></section><!----><section _ngcontent-ng-c4141810494 class="lps-col"><!----><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass3">Phase 2</h1><div _ngcontent-ng-c4141810494 class="contentClass3">The study drug is given to a larger group of people (100–300) to determine its effectiveness and to further study its safety.</div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></section><!----><section _ngcontent-ng-c4141810494 class="lps-col"><!----><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass3">Phase 3</h1><div _ngcontent-ng-c4141810494 class="contentClass3">The study drug is given to large groups of people (1,000–3,000) to confirm its effectiveness, monitor side effects, compare it with standard or similar drugs, and collect information that will allow the study drug to be used safely.</div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></section><!----><!----><section _ngcontent-ng-c4141810494 class="lps-col"><!----><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass3">Phase 4</h1><div _ngcontent-ng-c4141810494 class="contentClass3">After a drug is approved by the FDA and made available to the public, researchers track its safety in the general population, seeking more information about a drug's benefits, and optimal use.</div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></section><!----><!----></div></article><!----><!----></amg-landing-page-content><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><section _ngcontent-ng-c4141810494 class="landing-page-section componentClass4"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-100" id="landing-page-id4"><!----><div _ngcontent-ng-c4141810494 class="lps-content"><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass4"></h1><div _ngcontent-ng-c4141810494 class="lps-content contentClass4"><a href="https://www.nih.gov/health-information/nih-clinical-research-trials-you/basics"> This information is available on the National Institute of Health NIH Clinical Research Trials and You page (accessed 17 July 2024)</a></div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></div></div></section><!----><!----><!----><!----><!----></amg-landing-page-content><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><!----><section _ngcontent-ng-c4141810494 class="landing-page-section componentClass5"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-5050" id="landing-page-id5"><div _ngcontent-ng-c4141810494 class="lps-text-col"><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass5">Real World Evidence Research</h1><div _ngcontent-ng-c4141810494 class="lps-content contentClass5">Real World Evidence (RWE) is another type of research and includes information on how treatments work in everyday settings, outside of the controlled environment of clinical trials. It comes from analyzing data collected from real-world data sources such as electronic health records, insurance claims, patient registries, and even wearable devices. RWE provides insights into how treatments perform in a broader, more diverse population of people and can help identify potential benefits or issues that weren’t apparent in clinical trials. </div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><!----><!----></div></div><div _ngcontent-ng-c4141810494 class="lps-media-col lps-flex-center lps-flex-top"><img _ngcontent-ng-c4141810494 alt class="lps-img" src="https://images.ctfassets.net/w00vjamh48ql/4Eq7w1hnzEtnyNMIvfx8c4/6a32dd2386c1a5fda557fd2b839f890c/RWE.jpg" height="2650" width="4000"></div><!----></div></section><!----><!----><!----><!----></amg-landing-page-content><amg-landing-page-content _ngcontent-ng-c4066735333 _nghost-ng-c4141810494><!----><section _ngcontent-ng-c4141810494 class="landing-page-section componentClass6"><!----><div _ngcontent-ng-c4141810494 class="content-layout lps-layout-5050 lps-layout-invert" id="landing-page-id6"><div _ngcontent-ng-c4141810494 class="lps-text-col"><h1 _ngcontent-ng-c4141810494 class="lps-heading titleClass6">Patient Reported Outcomes</h1><div _ngcontent-ng-c4141810494 class="lps-content contentClass6">One of the types of information that can be included in clinical trial research or in real world evidence are newer types of measures called Patient Reported Outcomes (PROs). PROs are reports that come directly from patients about how they feel and function in relation to their health condition and its treatment. <br><br>These reports provide valuable insights into the patient’s perspective on their symptoms, quality of life, and the impact of the treatment. Many clinical trials today are including PROs in the data collection, in addition to the data monitoring done by the doctor. PROs help ensure that the patient’s voice is included in evaluating the effectiveness and side effects of treatments.</div><div _ngcontent-ng-c4141810494 class="lps-actions"><!----><a _ngcontent-ng-c4141810494 id="layout-5050-btn" class="lps-btn buttonClass6"> I'M INTERESTED </a><!----><!----></div></div><div _ngcontent-ng-c4141810494 class="lps-media-col lps-flex-center lps-flex-mid"><img _ngcontent-ng-c4141810494 alt class="lps-img" src="https://images.ctfassets.net/w00vjamh48ql/4Xzbpy4282fa8yETTVAy3w/c4ccd7745a45c74fe60463b99cd5e6bd/image.jpg" height="930" width="1395"></div><!----></div></section><!----><!----><!----><!----></amg-landing-page-content><!----><!----><!----></amg-research-landing-page><!----></div><ins-custom-modal id="error-modal" _nghost-ng-c1921762676 class="cmw-hide"><!----><div _ngcontent-ng-c1921762676 id="ins-modal-wrapper" class="custom-modal-wrapper"><div _ngcontent-ng-c1921762676 class="cmw-dialog"><a _ngcontent-ng-c1921762676 id="custom_modal_close" class="cmw-close"><ins-svg-icon _ngcontent-ng-c1921762676 icontype="close" _nghost-ng-c33518352><svg _ngcontent-ng-c33518352="" fill="currentColor" width="1em" height="1em" viewBox="0 0 1024 1024"><use _ngcontent-ng-c33518352="" href="/assets/svgs/symbol-defs.svg?t=7#close"/></svg></ins-svg-icon></a><!----><app-error-modal _nghost-ng-c2366512457><section _ngcontent-ng-c2366512457 class="error-modal-block cmw-inner"><div _ngcontent-ng-c2366512457 class="emb-title">Oops, something went wrong.</div><div _ngcontent-ng-c2366512457 class="emb-desc">Please try again later.</div><button _ngcontent-ng-c2366512457 type="button" class="bttn bttn-md bttn-secondary emb-btn">Ok</button></section></app-error-modal><!----><!----></div></div><!----></ins-custom-modal><ins-modal-listener _nghost-ng-c110737693><!----></ins-modal-listener><!----><amgl-footer class="no-print" _nghost-ng-c1705168895><div _ngcontent-ng-c1705168895 class="footer-component-block"><div _ngcontent-ng-c1705168895 class="fcb-content"><nav _ngcontent-ng-c1705168895 class="fcb-actions"><div _ngcontent-ng-c1705168895 class="fcb-a-col"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_learning_center" class="fcb-a-link" href="/learning-center/"> Learning Center </a><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_discussions" class="fcb-a-link" href="/groups/cardiovascular-journey/"> Discussions </a><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_research" class="fcb-a-link" href="/research/"> Research </a></div><div _ngcontent-ng-c1705168895 class="fcb-a-col"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_about_and_help" class="fcb-a-link" href="/about/"> About &amp; Help </a><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_urgent_help" class="fcb-a-link" href="/about/urgent-help/"> Urgent Help </a><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_contact" class="fcb-a-link" href="/contact/"> Contact </a></div></nav><a _ngcontent-ng-c1705168895 class="fcb-logo"><img _ngcontent-ng-c1705168895 loading="lazy" src="/assets/img/amgen-logo-light.svg" alt="Amgen" class="fcb-img"><img _ngcontent-ng-c1705168895 loading="lazy" src="/assets/img/amgen-logo-grey.svg" alt="Amgen" class="fcb-img fcb-img-dark"></a></div><ul _ngcontent-ng-c1705168895 class="fcb-extra"><li _ngcontent-ng-c1705168895 class="fcb-e-item"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_The_PARC" class="fcb-e-link" href="/">The PARC</a></li><li _ngcontent-ng-c1705168895 class="fcb-e-item"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_privacy_statement" class="fcb-e-link" href="/about/privacy/">Privacy statement</a></li><li _ngcontent-ng-c1705168895 class="fcb-e-item"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_terms_of_use" class="fcb-e-link" href="/about/terms-of-use/">Terms of use</a></li><li _ngcontent-ng-c1705168895 class="fcb-e-item"><a _ngcontent-ng-c1705168895 setlinktodummyanchor id="footer_link_consumer_health_and_data_privacy" class="fcb-e-link" href="/about/consumer-health-data-privacy-policy/">Consumer health data privacy policy</a></li><li _ngcontent-ng-c1705168895 class="fcb-e-item"><a _ngcontent-ng-c1705168895 id="footer_link_cookie_preferences" class="fcb-e-link">Cookie preferences</a></li></ul><div _ngcontent-ng-c1705168895 class="fcb-copyright"><div _ngcontent-ng-c1705168895 class="fcb-c-inner">© 2024 Amgen. 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