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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Hani Wadei</h3></div><div class="js-work-strip profile--work_container" data-work-id="104903250"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104903250/Karyomegalic_interstitial_nephritis_in_a_renal_allograft"><img alt="Research paper thumbnail of Karyomegalic interstitial nephritis in a renal allograft" class="work-thumbnail" src="https://attachments.academia-assets.com/104506692/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104903250/Karyomegalic_interstitial_nephritis_in_a_renal_allograft">Karyomegalic interstitial nephritis in a renal allograft</a></div><div class="wp-workCard_item"><span>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</span><span>, Jan 24, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characteriz...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characterized by large tubular nuclei, accompanied by interstitial inflammation, tubular atrophy, and interstitial fibrosis. Approximately 50 cases of KIN have been described in the native kidney. In this case study, we describe the first case of KIN in a kidney allograft. A 41-year-old man presented with declining kidney function and a serum creatinine of 2.7 mg/dL. The native kidney biopsy showed large pleomorphic nuclei in the proximal and distal tubular epithelial cells, which was associated with interstitial inflammation, and extensive interstitial fibrosis and tubular atrophy. Immunohistochemistry for cytomegalovirus, adenovirus, and simian virus 40 were negative. A diagnosis of KIN was rendered. The patient received a living-related kidney transplant from his sister. At 4-, 12-, and 24-months posttransplant, protocol allograft biopsies showed KIN with large pleomorphic nuclei in the proximal...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c78cad447265c0a6f20060b9ff3e9409" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104506692,"asset_id":104903250,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104506692/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104903250"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104903250"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104903250; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104903250]").text(description); $(".js-view-count[data-work-id=104903250]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104903250; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104903250']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104903250, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c78cad447265c0a6f20060b9ff3e9409" } } $('.js-work-strip[data-work-id=104903250]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104903250,"title":"Karyomegalic interstitial nephritis in a renal allograft","translated_title":"","metadata":{"abstract":"Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characterized by large tubular nuclei, accompanied by interstitial inflammation, tubular atrophy, and interstitial fibrosis. Approximately 50 cases of KIN have been described in the native kidney. In this case study, we describe the first case of KIN in a kidney allograft. A 41-year-old man presented with declining kidney function and a serum creatinine of 2.7 mg/dL. The native kidney biopsy showed large pleomorphic nuclei in the proximal and distal tubular epithelial cells, which was associated with interstitial inflammation, and extensive interstitial fibrosis and tubular atrophy. Immunohistochemistry for cytomegalovirus, adenovirus, and simian virus 40 were negative. A diagnosis of KIN was rendered. The patient received a living-related kidney transplant from his sister. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591522"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591522/Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors"><img alt="Research paper thumbnail of Simultaneous Liver-Kidney Transplantation From Donation After Cardiac Death Donors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591522/Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors">Simultaneous Liver-Kidney Transplantation From Donation After Cardiac Death Donors</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591522"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591522"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591522; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591521"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal"><img alt="Research paper thumbnail of Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal">Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal</a></div><div class="wp-workCard_item"><span>Clinical transplantation</span><span>, Jan 25, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591521"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591521"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591521; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591521]").text(description); $(".js-view-count[data-work-id=17591521]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591521; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591521']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591521, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591521]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591521,"title":"Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal","translated_title":"","metadata":{"abstract":"Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...","publication_date":{"day":25,"month":1,"year":2015,"errors":{}},"publication_name":"Clinical transplantation"},"translated_abstract":"Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...","internal_url":"https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:59:00.565-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591520"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function"><img alt="Research paper thumbnail of Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function">Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) perform...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591520"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591520"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591520; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591520]").text(description); $(".js-view-count[data-work-id=17591520]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591520; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591520']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591520, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591520]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591520,"title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function","translated_title":"","metadata":{"abstract":"Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":"Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.","internal_url":"https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function","translated_internal_url":"","created_at":"2015-11-01T20:59:00.469-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455158,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455191,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897367,"email":"m***e@uab.edu","display_order":6291456,"name":"Mary Prendergast","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455206,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":48381459,"co_author_invite_id":1431559,"email":"w***i@vet.upenn.edu","display_order":7340032,"name":"Wilfried Mai","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455258,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1009394,"email":"t***n@mayo.edu","display_order":7864320,"name":"Burcin Taner","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"}],"downloadable_attachments":[],"slug":"Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":2122,"name":"Death","url":"https://www.academia.edu/Documents/in/Death"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591519"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure"><img alt="Research paper thumbnail of The role of the kidney in regulating arterial blood pressure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure">The role of the kidney in regulating arterial blood pressure</a></div><div class="wp-workCard_item"><span>Nature Reviews Nephrology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The kidney plays a central role in the regulation of arterial blood pressure. A large body of exp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake &amp;amp;amp;amp;amp;amp;amp;#39;follows&amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a &amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney&amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a &amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney&amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591519"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591519"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591519; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591519]").text(description); $(".js-view-count[data-work-id=17591519]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591519; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591519']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591519, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591519]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591519,"title":"The role of the kidney in regulating arterial blood pressure","translated_title":"","metadata":{"abstract":"The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake \u0026amp;amp;amp;amp;amp;amp;amp;#39;follows\u0026amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Nature Reviews Nephrology"},"translated_abstract":"The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake \u0026amp;amp;amp;amp;amp;amp;amp;#39;follows\u0026amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.","internal_url":"https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure","translated_internal_url":"","created_at":"2015-11-01T20:59:00.370-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455246,"work_id":17591519,"tagging_user_id":37425114,"tagged_user_id":50902978,"co_author_invite_id":1897388,"email":"t***n@mayo.edu","display_order":0,"name":"Stephen Textor","title":"The role of the kidney in regulating arterial blood pressure"}],"downloadable_attachments":[],"slug":"The_role_of_the_kidney_in_regulating_arterial_blood_pressure","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591518"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591518/A_Brain_Kidney_Connection_The_Delicate_Interplay_of_Brain_and_Kidney_Physiology"><img alt="Research paper thumbnail of A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591518/A_Brain_Kidney_Connection_The_Delicate_Interplay_of_Brain_and_Kidney_Physiology">A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology</a></div><div class="wp-workCard_item"><span>Neurocritical Care</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591518"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591518"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591518; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591517"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591517/Renal_Outcomes_of_Liver_Transplant_Recipients_Who_Had_Pretransplant_Kidney_Biopsy"><img alt="Research paper thumbnail of Renal Outcomes of Liver Transplant Recipients Who Had Pretransplant Kidney Biopsy" class="work-thumbnail" src="https://attachments.academia-assets.com/39600258/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591517/Renal_Outcomes_of_Liver_Transplant_Recipients_Who_Had_Pretransplant_Kidney_Biopsy">Renal Outcomes of Liver Transplant Recipients Who Had Pretransplant Kidney Biopsy</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8d8b6a29e6f37a3de1afb7ddac61ef33" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39600258,"asset_id":17591517,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39600258/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591517"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591517"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591517; 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Kidney biopsy has been recommended to guide kidney allocation in selected liver transplant (LT) candidates with renal dysfunction. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591516"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591516/Rabbit_Anti_Thymocyte_Globulin_Evidence_for_Clinical_Benefit_in_High_Immunological_Risk_Kidney_Transplantation"><img alt="Research paper thumbnail of Rabbit Anti-Thymocyte Globulin: Evidence for Clinical Benefit in High Immunological Risk Kidney Transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" 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href="https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation"><img alt="Research paper thumbnail of Comparison of Kidney Function Between Donation After Cardiac Death and Donation After Brain Death Kidney Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/39600280/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation">Comparison of Kidney Function Between Donation After Cardiac Death and Donation After Brain Death Kidney Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation Journal</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23f532f3fc31572e8cfd5c1b530fa2c9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39600280,"asset_id":17591515,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39600280/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591515"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item 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Kidney graft survival is comparable between donation after cardiac death (DCD) and donation after brain death (DBD) kidney transplantation. However, data concerning kidney function after DCD kidney transplantation are lacking. Methods. We retrospectively compared kidney function between 64 DCD and 248 DBD kidney transplant recipients. Graft function was assessed using iothalamate glomerular filtration rate at 1, 4, and 12 months, then annually. The primary endpoint was the composite of death-censored graft loss or two consecutive iothalamate glomerular filtration rates less than 50 mL/min/1.73 m 2 occurring within 5 years from transplantation. Secondary endpoints included death and graft loss or death. Results. Of the 312 patients, 102 (33%) experienced the primary endpoint, 78 (25%) experienced graft loss or death, and 44 (14%) died. In multivariable Cox regression analysis, there was no difference between DCD and DBD recipients regarding the primary endpoint (relative risk [RR], 1.16; P=0.59), death (RR, 0.97; P=0.94), or graft loss or death (RR, 1.09; P=0.79). In the subgroup of 64 DCD recipients, each 10-year increase in donor age was associated with increased risk of the primary endpoint (RR, 1.51; P=0.027) with the highest risk observed for donors older than 45 years (RR, 4.81; P=0.001). Delayed graft function affected 45% of the DCD recipients but had no impact on kidney function, graft survival, or patient survival. Conclusions. Posttransplantation kidney function is comparable between DCD and DBD kidney transplantations. In the subgroup of DCD recipients, kidneys from donors older than 45 years may be associated with a higher risk of poor kidney function; however, this finding requires validation in a larger patient group.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Transplantation Journal","grobid_abstract_attachment_id":39600280},"translated_abstract":null,"internal_url":"https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation","translated_internal_url":"","created_at":"2015-11-01T20:58:59.974-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455159,"work_id":17591515,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Comparison 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591514/Excellent_renal_allograft_survival_in_donor_specific_antibody_positive_transplant_patients_role_of_intravenous_immunoglobulin_and_rabbit_antithymocyte_globulin"><img alt="Research paper thumbnail of Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin" class="work-thumbnail" src="https://attachments.academia-assets.com/39600274/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591514/Excellent_renal_allograft_survival_in_donor_specific_antibody_positive_transplant_patients_role_of_intravenous_immunoglobulin_and_rabbit_antithymocyte_globulin">Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GrewalHani">Hani Grewal</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, Jan 27, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a compl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a complement-dependent cytotoxicity negative and flow cytometry (FC) positive crossmatch carry increased risk of antibody-mediated rejection and thus graft loss. Solid phase assays are available to confirm donor specificity for antibody identified by FC crossmatch. Treatment using induction therapy with rabbit antithymocyte globulin (RATG) and intravenous immunoglobulin (IVIG) may allow successful transplant of these high-risk patients. A retrospective study of 264 consecutive patients after exclusions yielded 94 complement-dependent cytotoxicity anti-human globulin crossmatch-negative patients, including group 1: 58 primary transplants with panel-reactive antibody (PRA) less than 20%, group 2: 16 retransplants and PRA more than 20% who were FC crossmatch-negative, and group 3: 20 retransplants and PRA more than 20% who were FC crossmatch-positive. All were treated with RATG induction and maint...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8d56a59ca05cab1c98022bd799b2c1d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39600274,"asset_id":17591514,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39600274/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591514"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591514"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591514; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591514]").text(description); $(".js-view-count[data-work-id=17591514]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591514; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591514']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591514, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8d56a59ca05cab1c98022bd799b2c1d5" } } $('.js-work-strip[data-work-id=17591514]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591514,"title":"Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin","translated_title":"","metadata":{"abstract":"Timely transplantation of sensitized kidney recipients remains a challenge. 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href="https://www.academia.edu/17591513/Clinical_Decisions_in_Nephrology_Hypertension_and_Kidney_Transplantation"><img alt="Research paper thumbnail of Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591513/Clinical_Decisions_in_Nephrology_Hypertension_and_Kidney_Transplantation">Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591513"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591513"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591513; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591513]").text(description); $(".js-view-count[data-work-id=17591513]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x 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href="https://www.academia.edu/17591512/Preemptive_Living_Donor_Kidney_Transplantation_Do_the_Benefits_Extend_to_All_Recipients"><img alt="Research paper thumbnail of Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591512/Preemptive_Living_Donor_Kidney_Transplantation_Do_the_Benefits_Extend_to_All_Recipients">Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/EduardoRamos86">Eduardo Ramos</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AhmedDonia1">Ahmed Donia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StephenTextor">Stephen Textor</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://mayoclinic.academia.edu/MikelPrieto">Mikel Prieto</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dialysis is not only associated with morbidity, it is also expensive. In developing countries, pr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dialysis is not only associated with morbidity, it is also expensive. In developing countries, preemptive renal transplantation (Tx) may be a cost-effective option, offering an additional benefit to conventional renal Tx. Between March 1976 and March 2001, 1,279 first living-donor Txs were performed in our center. The 82 patients (6.4%) who underwent Tx without prior dialysis were compared with 1,197 patients who had been dialyzed before Tx. The dialysis-dependent group received more blood transfusions (65% vs. 30%) before Tx. Actuarial graft and patient survival at 5 years was comparable in both groups (P =0.2 and P =0.8, respectively). The incidence of acute and chronic rejection was not different between the two groups. Mortality rate was also similar in the two groups. The main cause of death with a functioning graft was cardiovascular in the preemptive Tx group and chronic liver disease and infection in the control group. In the context of a developing country, preemptive Tx offers comparable patient and graft survival to conventional renal Tx and eliminates the complications, inconvenience, and cost of dialysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591512"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591512"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591512; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591512]").text(description); $(".js-view-count[data-work-id=17591512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591512, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591512]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591512,"title":"Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?","translated_title":"","metadata":{"abstract":"Dialysis is not only associated with morbidity, it is also expensive. In developing countries, preemptive renal transplantation (Tx) may be a cost-effective option, offering an additional benefit to conventional renal Tx. Between March 1976 and March 2001, 1,279 first living-donor Txs were performed in our center. The 82 patients (6.4%) who underwent Tx without prior dialysis were compared with 1,197 patients who had been dialyzed before Tx. The dialysis-dependent group received more blood transfusions (65% vs. 30%) before Tx. Actuarial graft and patient survival at 5 years was comparable in both groups (P =0.2 and P =0.8, respectively). The incidence of acute and chronic rejection was not different between the two groups. Mortality rate was also similar in the two groups. The main cause of death with a functioning graft was cardiovascular in the preemptive Tx group and chronic liver disease and infection in the control group. In the context of a developing country, preemptive Tx offers comparable patient and graft survival to conventional renal Tx and eliminates the complications, inconvenience, and cost of dialysis.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Dialysis is not only associated with morbidity, it is also expensive. In developing countries, preemptive renal transplantation (Tx) may be a cost-effective option, offering an additional benefit to conventional renal Tx. Between March 1976 and March 2001, 1,279 first living-donor Txs were performed in our center. The 82 patients (6.4%) who underwent Tx without prior dialysis were compared with 1,197 patients who had been dialyzed before Tx. The dialysis-dependent group received more blood transfusions (65% vs. 30%) before Tx. Actuarial graft and patient survival at 5 years was comparable in both groups (P =0.2 and P =0.8, respectively). The incidence of acute and chronic rejection was not different between the two groups. Mortality rate was also similar in the two groups. The main cause of death with a functioning graft was cardiovascular in the preemptive Tx group and chronic liver disease and infection in the control group. In the context of a developing country, preemptive Tx offers comparable patient and graft survival to conventional renal Tx and eliminates the complications, inconvenience, and cost of dialysis.","internal_url":"https://www.academia.edu/17591512/Preemptive_Living_Donor_Kidney_Transplantation_Do_the_Benefits_Extend_to_All_Recipients","translated_internal_url":"","created_at":"2015-11-01T20:58:59.687-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455116,"work_id":17591512,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897363,"email":"c***o@mayo.edu","display_order":0,"name":"Fernando Cosio","title":"Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All 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Recipient" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591511/Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient">Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GregoryBroderick1">Gregory Broderick</a></span></div><div class="wp-workCard_item"><span>Urology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591511"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591511"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591511; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591511]").text(description); $(".js-view-count[data-work-id=17591511]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591511; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591511']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591511, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591511]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591511,"title":"Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient","translated_title":"","metadata":{"abstract":"Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Urology"},"translated_abstract":"Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.","internal_url":"https://www.academia.edu/17591511/Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient","translated_internal_url":"","created_at":"2015-11-01T20:58:59.600-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455227,"work_id":17591511,"tagging_user_id":37425114,"tagged_user_id":37591059,"co_author_invite_id":1897380,"email":"b***y@mayo.edu","display_order":4194304,"name":"Gregory Broderick","title":"Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient"}],"downloadable_attachments":[],"slug":"Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":988280,"name":"Abscess","url":"https://www.academia.edu/Documents/in/Abscess"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients"><img alt="Research paper thumbnail of Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients">Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients</a></div><div class="wp-workCard_item"><span>Transplantation Journal</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591510]").text(description); $(".js-view-count[data-work-id=17591510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591510, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591510]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591510,"title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients","translated_title":"","metadata":{"abstract":"The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Transplantation Journal"},"translated_abstract":"The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.","internal_url":"https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients","translated_internal_url":"","created_at":"2015-11-01T20:58:59.514-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455157,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455197,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897368,"email":"b***r@cc.umanitoba.ca","display_order":6291456,"name":"Barry Rosser","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455212,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897374,"email":"m***s@sheffield.ac.uk","display_order":7340032,"name":"Melanie Jones","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455257,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1009394,"email":"t***n@mayo.edu","display_order":7864320,"name":"Burcin Taner","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"}],"downloadable_attachments":[],"slug":"Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":777616,"name":"Proteinuria","url":"https://www.academia.edu/Documents/in/Proteinuria"},{"id":917174,"name":"Calcineurin inhibitors","url":"https://www.academia.edu/Documents/in/Calcineurin_inhibitors"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal"><img alt="Research paper thumbnail of Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal">Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HariniChakkera">Harini Chakkera</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591509; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591509]").text(description); $(".js-view-count[data-work-id=17591509]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591509; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591509']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591509, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591509]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591509,"title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal","translated_title":"","metadata":{"abstract":"The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.","internal_url":"https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:58:59.404-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455149,"work_id":17591509,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal"},{"id":8455261,"work_id":17591509,"tagging_user_id":37425114,"tagged_user_id":37613544,"co_author_invite_id":1897389,"email":"c***i@mayo.edu","display_order":6291456,"name":"Harini Chakkera","title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal"}],"downloadable_attachments":[],"slug":"Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591508"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database"><img alt="Research paper thumbnail of Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database">Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients after liver transplant have a high incidence of chronic kidney disease and end-stage ren...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591508"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591508"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591508; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591508]").text(description); $(".js-view-count[data-work-id=17591508]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591508; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591508']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591508, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591508]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591508,"title":"Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database","translated_title":"","metadata":{"abstract":"Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.","internal_url":"https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database","translated_internal_url":"","created_at":"2015-11-01T20:58:59.298-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455154,"work_id":17591508,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database"}],"downloadable_attachments":[],"slug":"Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":917174,"name":"Calcineurin inhibitors","url":"https://www.academia.edu/Documents/in/Calcineurin_inhibitors"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal"><img alt="Research paper thumbnail of Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal">Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591507]").text(description); $(".js-view-count[data-work-id=17591507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591507, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591507,"title":"Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal","translated_title":"","metadata":{"abstract":"Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.","internal_url":"https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:58:59.210-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455148,"work_id":17591507,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal"}],"downloadable_attachments":[],"slug":"Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3900970" id="papers"><div class="js-work-strip profile--work_container" data-work-id="104903250"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104903250/Karyomegalic_interstitial_nephritis_in_a_renal_allograft"><img alt="Research paper thumbnail of Karyomegalic interstitial nephritis in a renal allograft" class="work-thumbnail" src="https://attachments.academia-assets.com/104506692/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104903250/Karyomegalic_interstitial_nephritis_in_a_renal_allograft">Karyomegalic interstitial nephritis in a renal allograft</a></div><div class="wp-workCard_item"><span>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</span><span>, Jan 24, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characteriz...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characterized by large tubular nuclei, accompanied by interstitial inflammation, tubular atrophy, and interstitial fibrosis. Approximately 50 cases of KIN have been described in the native kidney. In this case study, we describe the first case of KIN in a kidney allograft. A 41-year-old man presented with declining kidney function and a serum creatinine of 2.7 mg/dL. The native kidney biopsy showed large pleomorphic nuclei in the proximal and distal tubular epithelial cells, which was associated with interstitial inflammation, and extensive interstitial fibrosis and tubular atrophy. Immunohistochemistry for cytomegalovirus, adenovirus, and simian virus 40 were negative. A diagnosis of KIN was rendered. The patient received a living-related kidney transplant from his sister. At 4-, 12-, and 24-months posttransplant, protocol allograft biopsies showed KIN with large pleomorphic nuclei in the proximal...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c78cad447265c0a6f20060b9ff3e9409" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104506692,"asset_id":104903250,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104506692/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104903250"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104903250"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104903250; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104903250]").text(description); $(".js-view-count[data-work-id=104903250]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104903250; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104903250']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104903250, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c78cad447265c0a6f20060b9ff3e9409" } } $('.js-work-strip[data-work-id=104903250]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104903250,"title":"Karyomegalic interstitial nephritis in a renal allograft","translated_title":"","metadata":{"abstract":"Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characterized by large tubular nuclei, accompanied by interstitial inflammation, tubular atrophy, and interstitial fibrosis. Approximately 50 cases of KIN have been described in the native kidney. In this case study, we describe the first case of KIN in a kidney allograft. A 41-year-old man presented with declining kidney function and a serum creatinine of 2.7 mg/dL. The native kidney biopsy showed large pleomorphic nuclei in the proximal and distal tubular epithelial cells, which was associated with interstitial inflammation, and extensive interstitial fibrosis and tubular atrophy. Immunohistochemistry for cytomegalovirus, adenovirus, and simian virus 40 were negative. A diagnosis of KIN was rendered. The patient received a living-related kidney transplant from his sister. At 4-, 12-, and 24-months posttransplant, protocol allograft biopsies showed KIN with large pleomorphic nuclei in the proximal...","publication_date":{"day":24,"month":1,"year":2018,"errors":{}},"publication_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},"translated_abstract":"Karyomegalic interstitial nephritis (KIN) is a rare renal interstitial disease entity characterized by large tubular nuclei, accompanied by interstitial inflammation, tubular atrophy, and interstitial fibrosis. Approximately 50 cases of KIN have been described in the native kidney. In this case study, we describe the first case of KIN in a kidney allograft. A 41-year-old man presented with declining kidney function and a serum creatinine of 2.7 mg/dL. The native kidney biopsy showed large pleomorphic nuclei in the proximal and distal tubular epithelial cells, which was associated with interstitial inflammation, and extensive interstitial fibrosis and tubular atrophy. Immunohistochemistry for cytomegalovirus, adenovirus, and simian virus 40 were negative. A diagnosis of KIN was rendered. The patient received a living-related kidney transplant from his sister. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591523"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591523/Influence_of_Immunosuppression_Donor_Age_and_Rejection_on_Chronic_Banff_Scores_of_1_Year_Protocol_Biopsies_in_a_Prospective_Randomized_Trial_of_Tacrolimus_TAC_plus_Mycophenolate_Mofetil_MMF_vs_Sirolimus_SRL_plus_MMF_Therapy_Following_Thymoglobulib_THY_Induction_with_Rapid_Steroid_Taper_"><img alt="Research paper thumbnail of Influence of Immunosuppression, Donor Age, and Rejection on Chronic Banff Scores of 1 Year Protocol Biopsies in a Prospective Randomized Trial of Tacrolimus (TAC) plus Mycophenolate Mofetil (MMF) vs. Sirolimus (SRL) plus MMF Therapy Following Thymoglobulib (THY) Induction with Rapid Steroid Taper..." class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591523/Influence_of_Immunosuppression_Donor_Age_and_Rejection_on_Chronic_Banff_Scores_of_1_Year_Protocol_Biopsies_in_a_Prospective_Randomized_Trial_of_Tacrolimus_TAC_plus_Mycophenolate_Mofetil_MMF_vs_Sirolimus_SRL_plus_MMF_Therapy_Following_Thymoglobulib_THY_Induction_with_Rapid_Steroid_Taper_">Influence of Immunosuppression, Donor Age, and Rejection on Chronic Banff Scores of 1 Year Protocol Biopsies in a Prospective Randomized Trial of Tacrolimus (TAC) plus Mycophenolate Mofetil (MMF) vs. Sirolimus (SRL) plus MMF Therapy Following Thymoglobulib (THY) Induction with Rapid Steroid Taper...</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591523"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591523"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591523; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591522"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591522/Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors"><img alt="Research paper thumbnail of Simultaneous Liver-Kidney Transplantation From Donation After Cardiac Death Donors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591522/Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors">Simultaneous Liver-Kidney Transplantation From Donation After Cardiac Death Donors</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591522"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591522"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591522; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591522]").text(description); $(".js-view-count[data-work-id=17591522]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591522; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591522']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591522, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591522]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591522,"title":"Simultaneous Liver-Kidney Transplantation From Donation After Cardiac Death Donors","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/17591522/Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors","translated_internal_url":"","created_at":"2015-11-01T20:59:00.669-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Simultaneous_Liver_Kidney_Transplantation_From_Donation_After_Cardiac_Death_Donors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":2122,"name":"Death","url":"https://www.academia.edu/Documents/in/Death"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":790533,"name":"Liver Failure","url":"https://www.academia.edu/Documents/in/Liver_Failure"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591521"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal"><img alt="Research paper thumbnail of Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal">Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal</a></div><div class="wp-workCard_item"><span>Clinical transplantation</span><span>, Jan 25, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591521"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591521"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591521; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591521]").text(description); $(".js-view-count[data-work-id=17591521]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591521; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591521']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591521, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591521]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591521,"title":"Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non-sensitized renal transplant patients treated with rapid steroid withdrawal","translated_title":"","metadata":{"abstract":"Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...","publication_date":{"day":25,"month":1,"year":2015,"errors":{}},"publication_name":"Clinical transplantation"},"translated_abstract":"Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single-center, cohort study evaluated cumulative incidence of one-yr biopsy-proven acute rejection (BPAR) among 200 consecutive primary non-sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one-yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2-10.5, p = 0.02). Despite similar rates of ...","internal_url":"https://www.academia.edu/17591521/Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:59:00.565-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Comparison_of_alemtuzumab_vs_antithymocyte_globulin_induction_therapy_in_primary_non_sensitized_renal_transplant_patients_treated_with_rapid_steroid_withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591520"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function"><img alt="Research paper thumbnail of Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function">Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) perform...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591520"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591520"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591520; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591520]").text(description); $(".js-view-count[data-work-id=17591520]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591520; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591520']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591520, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591520]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591520,"title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function","translated_title":"","metadata":{"abstract":"Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Transplantation Proceedings"},"translated_abstract":"Recipients of primary transplants from donation after cardiac death (DCD) donors (n = 40) performed from January 2005 to December 2009 were retrospectively reviewed and compared with recipients of primary transplants from donation after brain death (DBD) donors (n = 142). Patients received rabbit antithymocyte globulin induction and rapid steroid taper (RST; steroids stopped 5 days after surgery). Maintenance immunosuppression included tacrolimus and mycophenolate mofetil. Protocol kidney biopsies, creatinine (Cr), and measured glomerular filtration rate (mGFR; determined by cold iothalamate or 24-h creatinine clearance) were obtained at 1, 4, 12, and 24 months. Kidney biopsies for cause were conducted for unexplained elevated Cr, decline in mGFR, or new proteinuria. Biopsies were graded for rejection according to the Banff criteria. Graft survival at 3 years was 90.0% for DCD recipients and 86.6% for DBD recipients (P = NS). Rejection of any grade diagnosed on any biopsy through the first 2 years occurred in 18 DCD (45%) and 50 DBD (35%) recipients. Rejection of a grade more than Banff borderline occurred in 12.5% DCD and 12.7% DBD recipients. At 2 years, the mean ± SEM Cr and mGFR for DCD recipients with rejection were 1.8 ± 0.29 mg/dL and 59.2 ± 8.5 mL/min versus 1.3 ± 0.11 mg/dL and 67.0 ± 7.8 ml/min for those without rejection. For DBD recipients with rejection, Cr and mGFR at 2 years were 1.7 ± 0.12 mg/dL and 54.0 ± 4.4 mL/min versus 1.4 ± 0.11 mg/dL and 66.6 ± 3.3 ml/min for those without rejection (P = NS). Comparing DCD to DBD, there was no statistical difference in mean Cr or mGFR outcomes. Regardless of group, grafts with delayed graft function had lower 3-year survival. DCD primary kidney transplant recipients treated with rabbit antithymocyte induction and RST have short-term graft survival and function equivalent to DBD recipients. RST appears to be acceptable immunosuppression for DCD recipients.","internal_url":"https://www.academia.edu/17591520/Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function","translated_internal_url":"","created_at":"2015-11-01T20:59:00.469-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455158,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455191,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897367,"email":"m***e@uab.edu","display_order":6291456,"name":"Mary Prendergast","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455206,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":48381459,"co_author_invite_id":1431559,"email":"w***i@vet.upenn.edu","display_order":7340032,"name":"Wilfried Mai","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"},{"id":8455258,"work_id":17591520,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1009394,"email":"t***n@mayo.edu","display_order":7864320,"name":"Burcin Taner","title":"Antithymocyte Globulin Induction and Rapid Steroid Taper Leads to Excellent Results in Kidney Transplantation With Donation After Cardiac Death Donors: Importance of Rejection and Delayed Graft Function"}],"downloadable_attachments":[],"slug":"Antithymocyte_Globulin_Induction_and_Rapid_Steroid_Taper_Leads_to_Excellent_Results_in_Kidney_Transplantation_With_Donation_After_Cardiac_Death_Donors_Importance_of_Rejection_and_Delayed_Graft_Function","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":2122,"name":"Death","url":"https://www.academia.edu/Documents/in/Death"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591519"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure"><img alt="Research paper thumbnail of The role of the kidney in regulating arterial blood pressure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure">The role of the kidney in regulating arterial blood pressure</a></div><div class="wp-workCard_item"><span>Nature Reviews Nephrology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The kidney plays a central role in the regulation of arterial blood pressure. A large body of exp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake &amp;amp;amp;amp;amp;amp;amp;#39;follows&amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a &amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney&amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a &amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney&amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591519"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591519"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591519; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591519]").text(description); $(".js-view-count[data-work-id=17591519]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591519; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591519']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591519, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591519]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591519,"title":"The role of the kidney in regulating arterial blood pressure","translated_title":"","metadata":{"abstract":"The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake \u0026amp;amp;amp;amp;amp;amp;amp;#39;follows\u0026amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Nature Reviews Nephrology"},"translated_abstract":"The kidney plays a central role in the regulation of arterial blood pressure. A large body of experimental and physiological evidence indicates that renal control of extracellular volume and renal perfusion pressure are closely involved in maintaining the arterial circulation and blood pressure. Renal artery perfusion pressure directly regulates sodium excretion-a process known as pressure natriuresis-and influences the activity of various vasoactive systems such as the renin-angiotensin-aldosterone system. As a result, many researchers argue that identifying any marked rise in blood pressure requires resetting of the relationship between arterial blood pressure and urinary sodium excretion, which can occur by an array of systemic or local mechanisms. Almost all of the monogenic forms of hypertension affect sites in the kidney associated with sodium handling and transport. Experimental models of spontaneous hypertension, such as the Dahl salt-sensitive rat, have been used to study the effects of kidney transplantation on blood pressure. Results from studies of kidney transplantation indicate that pressure sensitivity to sodium intake \u0026amp;amp;amp;amp;amp;amp;amp;#39;follows\u0026amp;amp;amp;amp;amp;amp;amp;#39; the kidney, meaning that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-resistant kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires sodium resistance, and that the recipient of a \u0026amp;amp;amp;amp;amp;amp;amp;#39;salt-sensitive kidney\u0026amp;amp;amp;amp;amp;amp;amp;#39; acquires pressure sensitivity. The examples above and discussed in this Review demonstrate that it should come as no surprise that most disorders that affect the kidney or the renal vasculature commonly lead to secondary forms of hypertension.","internal_url":"https://www.academia.edu/17591519/The_role_of_the_kidney_in_regulating_arterial_blood_pressure","translated_internal_url":"","created_at":"2015-11-01T20:59:00.370-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455246,"work_id":17591519,"tagging_user_id":37425114,"tagged_user_id":50902978,"co_author_invite_id":1897388,"email":"t***n@mayo.edu","display_order":0,"name":"Stephen Textor","title":"The role of the kidney in regulating arterial blood pressure"}],"downloadable_attachments":[],"slug":"The_role_of_the_kidney_in_regulating_arterial_blood_pressure","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591518"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591518/A_Brain_Kidney_Connection_The_Delicate_Interplay_of_Brain_and_Kidney_Physiology"><img alt="Research paper thumbnail of A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591518/A_Brain_Kidney_Connection_The_Delicate_Interplay_of_Brain_and_Kidney_Physiology">A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology</a></div><div class="wp-workCard_item"><span>Neurocritical Care</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591518"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591518"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591518; 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href="https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation"><img alt="Research paper thumbnail of Comparison of Kidney Function Between Donation After Cardiac Death and Donation After Brain Death Kidney Transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/39600280/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation">Comparison of Kidney Function Between Donation After Cardiac Death and Donation After Brain Death Kidney Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation Journal</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23f532f3fc31572e8cfd5c1b530fa2c9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39600280,"asset_id":17591515,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39600280/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591515"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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WowProfile.WorkStripView({ el: this, workJSON: {"id":17591515,"title":"Comparison of Kidney Function Between Donation After Cardiac Death and Donation After Brain Death Kidney Transplantation","translated_title":"","metadata":{"grobid_abstract":"Backgroud. Kidney graft survival is comparable between donation after cardiac death (DCD) and donation after brain death (DBD) kidney transplantation. However, data concerning kidney function after DCD kidney transplantation are lacking. Methods. We retrospectively compared kidney function between 64 DCD and 248 DBD kidney transplant recipients. Graft function was assessed using iothalamate glomerular filtration rate at 1, 4, and 12 months, then annually. The primary endpoint was the composite of death-censored graft loss or two consecutive iothalamate glomerular filtration rates less than 50 mL/min/1.73 m 2 occurring within 5 years from transplantation. Secondary endpoints included death and graft loss or death. Results. Of the 312 patients, 102 (33%) experienced the primary endpoint, 78 (25%) experienced graft loss or death, and 44 (14%) died. In multivariable Cox regression analysis, there was no difference between DCD and DBD recipients regarding the primary endpoint (relative risk [RR], 1.16; P=0.59), death (RR, 0.97; P=0.94), or graft loss or death (RR, 1.09; P=0.79). In the subgroup of 64 DCD recipients, each 10-year increase in donor age was associated with increased risk of the primary endpoint (RR, 1.51; P=0.027) with the highest risk observed for donors older than 45 years (RR, 4.81; P=0.001). Delayed graft function affected 45% of the DCD recipients but had no impact on kidney function, graft survival, or patient survival. Conclusions. Posttransplantation kidney function is comparable between DCD and DBD kidney transplantations. In the subgroup of DCD recipients, kidneys from donors older than 45 years may be associated with a higher risk of poor kidney function; however, this finding requires validation in a larger patient group.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Transplantation Journal","grobid_abstract_attachment_id":39600280},"translated_abstract":null,"internal_url":"https://www.academia.edu/17591515/Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation","translated_internal_url":"","created_at":"2015-11-01T20:58:59.974-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455159,"work_id":17591515,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Comparison 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Death and Donation After Brain Death Kidney Transplantation"}],"downloadable_attachments":[{"id":39600280,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39600280/thumbnails/1.jpg","file_name":"Comparison_of_Kidney_Function_Between_Do20151101-1631-7qsj99.pdf","download_url":"https://www.academia.edu/attachments/39600280/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_of_Kidney_Function_Between_Do.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39600280/Comparison_of_Kidney_Function_Between_Do20151101-1631-7qsj99-libre.pdf?1446440631=\u0026response-content-disposition=attachment%3B+filename%3DComparison_of_Kidney_Function_Between_Do.pdf\u0026Expires=1733347799\u0026Signature=RvcVDC-8~NZ2kLSnKMaVyR75INeFlU-AhlbkWw2noqDvYm6Q93WfTrDieZb6R2ae2pblD9fbR9ikpoXWclxSV44oUYAbjHEHAsx7EYxx4e-vZJecJsSsOv6W~5ZjCZV2ZHa7A8fSBH08EUm5~fvWkPlGEnvPmxxQz4bMPqsCiVzEfN8tVYZAg9AvQsmgnl7WPEUwvMMmbh03rzM-qSWRjGtyVQcP~qqSaTZ95DNN2NPbKf6OMUk3gKpek~EkMw1Vs4U0TzmN~MivnOAG7kjU5qje41wpRZCm58bgGojBtGFTpALFK3BxNn1n~oPHNH09o5hEGZYxvx-NC0m-YlPmhg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_of_Kidney_Function_Between_Donation_After_Cardiac_Death_and_Donation_After_Brain_Death_Kidney_Transplantation","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani 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transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":45951,"name":"Brain Death","url":"https://www.academia.edu/Documents/in/Brain_Death"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591514"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591514/Excellent_renal_allograft_survival_in_donor_specific_antibody_positive_transplant_patients_role_of_intravenous_immunoglobulin_and_rabbit_antithymocyte_globulin"><img alt="Research paper thumbnail of Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin" class="work-thumbnail" src="https://attachments.academia-assets.com/39600274/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591514/Excellent_renal_allograft_survival_in_donor_specific_antibody_positive_transplant_patients_role_of_intravenous_immunoglobulin_and_rabbit_antithymocyte_globulin">Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GrewalHani">Hani Grewal</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, Jan 27, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a compl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a complement-dependent cytotoxicity negative and flow cytometry (FC) positive crossmatch carry increased risk of antibody-mediated rejection and thus graft loss. Solid phase assays are available to confirm donor specificity for antibody identified by FC crossmatch. Treatment using induction therapy with rabbit antithymocyte globulin (RATG) and intravenous immunoglobulin (IVIG) may allow successful transplant of these high-risk patients. A retrospective study of 264 consecutive patients after exclusions yielded 94 complement-dependent cytotoxicity anti-human globulin crossmatch-negative patients, including group 1: 58 primary transplants with panel-reactive antibody (PRA) less than 20%, group 2: 16 retransplants and PRA more than 20% who were FC crossmatch-negative, and group 3: 20 retransplants and PRA more than 20% who were FC crossmatch-positive. All were treated with RATG induction and maint...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8d56a59ca05cab1c98022bd799b2c1d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39600274,"asset_id":17591514,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39600274/download_file?st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&st=MTczMzM0NDE5OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591514"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591514"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591514; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591514]").text(description); $(".js-view-count[data-work-id=17591514]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591514; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591514']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591514, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8d56a59ca05cab1c98022bd799b2c1d5" } } $('.js-work-strip[data-work-id=17591514]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591514,"title":"Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte globulin","translated_title":"","metadata":{"abstract":"Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a complement-dependent cytotoxicity negative and flow cytometry (FC) positive crossmatch carry increased risk of antibody-mediated rejection and thus graft loss. Solid phase assays are available to confirm donor specificity for antibody identified by FC crossmatch. Treatment using induction therapy with rabbit antithymocyte globulin (RATG) and intravenous immunoglobulin (IVIG) may allow successful transplant of these high-risk patients. A retrospective study of 264 consecutive patients after exclusions yielded 94 complement-dependent cytotoxicity anti-human globulin crossmatch-negative patients, including group 1: 58 primary transplants with panel-reactive antibody (PRA) less than 20%, group 2: 16 retransplants and PRA more than 20% who were FC crossmatch-negative, and group 3: 20 retransplants and PRA more than 20% who were FC crossmatch-positive. All were treated with RATG induction and maint...","publication_date":{"day":27,"month":1,"year":2009,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Timely transplantation of sensitized kidney recipients remains a challenge. Patients with a complement-dependent cytotoxicity negative and flow cytometry (FC) positive crossmatch carry increased risk of antibody-mediated rejection and thus graft loss. Solid phase assays are available to confirm donor specificity for antibody identified by FC crossmatch. Treatment using induction therapy with rabbit antithymocyte globulin (RATG) and intravenous immunoglobulin (IVIG) may allow successful transplant of these high-risk patients. A retrospective study of 264 consecutive patients after exclusions yielded 94 complement-dependent cytotoxicity anti-human globulin crossmatch-negative patients, including group 1: 58 primary transplants with panel-reactive antibody (PRA) less than 20%, group 2: 16 retransplants and PRA more than 20% who were FC crossmatch-negative, and group 3: 20 retransplants and PRA more than 20% who were FC crossmatch-positive. All were treated with RATG induction and maint...","internal_url":"https://www.academia.edu/17591514/Excellent_renal_allograft_survival_in_donor_specific_antibody_positive_transplant_patients_role_of_intravenous_immunoglobulin_and_rabbit_antithymocyte_globulin","translated_internal_url":"","created_at":"2015-11-01T20:58:59.881-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455156,"work_id":17591514,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Excellent renal allograft survival in donor-specific antibody positive transplant patients-role of intravenous immunoglobulin and rabbit antithymocyte 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href="https://www.academia.edu/17591513/Clinical_Decisions_in_Nephrology_Hypertension_and_Kidney_Transplantation"><img alt="Research paper thumbnail of Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591513/Clinical_Decisions_in_Nephrology_Hypertension_and_Kidney_Transplantation">Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591513"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591513"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591513; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591513]").text(description); $(".js-view-count[data-work-id=17591513]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x 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href="https://www.academia.edu/17591512/Preemptive_Living_Donor_Kidney_Transplantation_Do_the_Benefits_Extend_to_All_Recipients"><img alt="Research paper thumbnail of Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591512/Preemptive_Living_Donor_Kidney_Transplantation_Do_the_Benefits_Extend_to_All_Recipients">Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/EduardoRamos86">Eduardo Ramos</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AhmedDonia1">Ahmed Donia</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StephenTextor">Stephen Textor</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://mayoclinic.academia.edu/MikelPrieto">Mikel Prieto</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dialysis is not only associated with morbidity, it is also expensive. In developing countries, pr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dialysis is not only associated with morbidity, it is also expensive. In developing countries, preemptive renal transplantation (Tx) may be a cost-effective option, offering an additional benefit to conventional renal Tx. Between March 1976 and March 2001, 1,279 first living-donor Txs were performed in our center. The 82 patients (6.4%) who underwent Tx without prior dialysis were compared with 1,197 patients who had been dialyzed before Tx. The dialysis-dependent group received more blood transfusions (65% vs. 30%) before Tx. Actuarial graft and patient survival at 5 years was comparable in both groups (P =0.2 and P =0.8, respectively). The incidence of acute and chronic rejection was not different between the two groups. Mortality rate was also similar in the two groups. The main cause of death with a functioning graft was cardiovascular in the preemptive Tx group and chronic liver disease and infection in the control group. In the context of a developing country, preemptive Tx offers comparable patient and graft survival to conventional renal Tx and eliminates the complications, inconvenience, and cost of dialysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591512"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591512"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591512; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591512]").text(description); $(".js-view-count[data-work-id=17591512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591512, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591512]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591512,"title":"Preemptive Living Donor Kidney Transplantation: Do the Benefits Extend to All Recipients?","translated_title":"","metadata":{"abstract":"Dialysis is not only associated with morbidity, it is also expensive. 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In the context of a developing country, preemptive Tx offers comparable patient and graft survival to conventional renal Tx and eliminates the complications, inconvenience, and cost of dialysis.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Dialysis is not only associated with morbidity, it is also expensive. In developing countries, preemptive renal transplantation (Tx) may be a cost-effective option, offering an additional benefit to conventional renal Tx. Between March 1976 and March 2001, 1,279 first living-donor Txs were performed in our center. The 82 patients (6.4%) who underwent Tx without prior dialysis were compared with 1,197 patients who had been dialyzed before Tx. The dialysis-dependent group received more blood transfusions (65% vs. 30%) before Tx. Actuarial graft and patient survival at 5 years was comparable in both groups (P =0.2 and P =0.8, respectively). The incidence of acute and chronic rejection was not different between the two groups. Mortality rate was also similar in the two groups. The main cause of death with a functioning graft was cardiovascular in the preemptive Tx group and chronic liver disease and infection in the control group. 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Analysis","url":"https://www.academia.edu/Documents/in/Cost_Benefit_Analysis"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591511"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591511/Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient"><img alt="Research paper thumbnail of Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591511/Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient">Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GregoryBroderick1">Gregory Broderick</a></span></div><div class="wp-workCard_item"><span>Urology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591511"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591511"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591511; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591511]").text(description); $(".js-view-count[data-work-id=17591511]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591511; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591511']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591511, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591511]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591511,"title":"Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient","translated_title":"","metadata":{"abstract":"Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Urology"},"translated_abstract":"Seminal vesicle abscess is extremely rare and is associated with specific predisposing conditions. Here we report a polymicrobial seminal vesicle abscess in a kidney transplant recipient that was not associated with any of the known precipitating events.","internal_url":"https://www.academia.edu/17591511/Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient","translated_internal_url":"","created_at":"2015-11-01T20:58:59.600-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455227,"work_id":17591511,"tagging_user_id":37425114,"tagged_user_id":37591059,"co_author_invite_id":1897380,"email":"b***y@mayo.edu","display_order":4194304,"name":"Gregory Broderick","title":"Polymicrobial Seminal Vesical Abscess in a Kidney Transplant Recipient"}],"downloadable_attachments":[],"slug":"Polymicrobial_Seminal_Vesical_Abscess_in_a_Kidney_Transplant_Recipient","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":988280,"name":"Abscess","url":"https://www.academia.edu/Documents/in/Abscess"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients"><img alt="Research paper thumbnail of Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients">Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients</a></div><div class="wp-workCard_item"><span>Transplantation Journal</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591510]").text(description); $(".js-view-count[data-work-id=17591510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591510, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591510]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591510,"title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients","translated_title":"","metadata":{"abstract":"The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Transplantation Journal"},"translated_abstract":"The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds ratio [OR]: 3.3, confidence interval [CI]: 1.1-9.5 P=0.03), post-LT diabetes (OR: 4.2, CI: 1.6-11.1, P=0.004), and higher eGFR at time of conversion (OR: 1.6, CI: 1.2-2.2, P=0.003). Improvement or stabilization of kidney function occurred in the majority of LT recipients converted to SRL for CNI nephrotoxicity. Proteinuria ≥ 1000 mg/day, post-LT diabetes, and higher baseline eGFR were independent predictors of kidney function loss after SRL conversion.","internal_url":"https://www.academia.edu/17591510/Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients","translated_internal_url":"","created_at":"2015-11-01T20:58:59.514-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455157,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455197,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897368,"email":"b***r@cc.umanitoba.ca","display_order":6291456,"name":"Barry Rosser","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455212,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1897374,"email":"m***s@sheffield.ac.uk","display_order":7340032,"name":"Melanie Jones","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"},{"id":8455257,"work_id":17591510,"tagging_user_id":37425114,"tagged_user_id":null,"co_author_invite_id":1009394,"email":"t***n@mayo.edu","display_order":7864320,"name":"Burcin Taner","title":"Proteinuria Following Sirolimus Conversion is Associated With Deterioration of Kidney Function in Liver Transplant Recipients"}],"downloadable_attachments":[],"slug":"Proteinuria_Following_Sirolimus_Conversion_is_Associated_With_Deterioration_of_Kidney_Function_in_Liver_Transplant_Recipients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":777616,"name":"Proteinuria","url":"https://www.academia.edu/Documents/in/Proteinuria"},{"id":917174,"name":"Calcineurin inhibitors","url":"https://www.academia.edu/Documents/in/Calcineurin_inhibitors"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal"><img alt="Research paper thumbnail of Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal">Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HariniChakkera">Harini Chakkera</a></span></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591509; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591509]").text(description); $(".js-view-count[data-work-id=17591509]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591509; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591509']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591509, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591509]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591509,"title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal","translated_title":"","metadata":{"abstract":"The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. The aim of this study was to determine the outcome of a prospective randomized trial of kidney transplant recipients receiving rapid corticosteroid withdrawal, tacrolimus and mycophenolate mofetil (MMF) for 1 month followed by randomization to switch to sirolimus-MMF or to stay on tacrolimus-MMF. The primary outcome was the difference in measured GFR at 1 year using intention-to-treat analysis. Sixty patients were randomized to stay on tacrolimus-MMF and 62 to sirolimus-MMF. Actual graft survival (including death) at 2 years was 98.4% in the sirolimus group, 96.7% in the tacrolimus group. Sixty-three percentage of the patients in the sirolimus group withdrew during the 2-year period of the study compared with 18% of the tacrolimus group (P\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), primarily related to rejection or medication side effects. Rejection during the first year occurred in 5% of the tacrolimus group and 13% of the sirolimus group (P=0.15). Measured GFR at 1 year (mean±SD) was 57.4±20.7 mL/min/1.73 m in the sirolimus group and 62.7±26.5 mL/min/1.73 m in the tacrolimus group (95% CI of difference -3.7-14.4). We conclude that conversion from tacrolimus-MMF to sirolimus-MMF at 1 month posttransplant in kidney recipients on rapid steroid withdrawal is poorly tolerated and does not improve GFR at 1 year.","internal_url":"https://www.academia.edu/17591509/Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:58:59.404-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455149,"work_id":17591509,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal"},{"id":8455261,"work_id":17591509,"tagging_user_id":37425114,"tagged_user_id":37613544,"co_author_invite_id":1897389,"email":"c***i@mayo.edu","display_order":6291456,"name":"Harini Chakkera","title":"Results of a Prospective Randomized Trial of Sirolimus Conversion in Kidney Transplant Recipients on Early Corticosteroid Withdrawal"}],"downloadable_attachments":[],"slug":"Results_of_a_Prospective_Randomized_Trial_of_Sirolimus_Conversion_in_Kidney_Transplant_Recipients_on_Early_Corticosteroid_Withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591508"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database"><img alt="Research paper thumbnail of Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database">Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients after liver transplant have a high incidence of chronic kidney disease and end-stage ren...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591508"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591508"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591508; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591508]").text(description); $(".js-view-count[data-work-id=17591508]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591508; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591508']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591508, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591508]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591508,"title":"Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database","translated_title":"","metadata":{"abstract":"Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.","internal_url":"https://www.academia.edu/17591508/Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database","translated_internal_url":"","created_at":"2015-11-01T20:58:59.298-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455154,"work_id":17591508,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Kidney Transplantation After Previous Liver Transplantation: Analysis of the Organ Procurement Transplant Network Database"}],"downloadable_attachments":[],"slug":"Kidney_Transplantation_After_Previous_Liver_Transplantation_Analysis_of_the_Organ_Procurement_Transplant_Network_Database","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":917174,"name":"Calcineurin inhibitors","url":"https://www.academia.edu/Documents/in/Calcineurin_inhibitors"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17591507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal"><img alt="Research paper thumbnail of Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal">Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal</a></div><div class="wp-workCard_item"><span>Transplantation</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17591507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17591507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17591507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17591507]").text(description); $(".js-view-count[data-work-id=17591507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17591507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17591507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 17591507, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17591507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17591507,"title":"Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal","translated_title":"","metadata":{"abstract":"Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Transplantation"},"translated_abstract":"Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We compared the chronic changes (IFTA and sum of Banff chronic scores--Total Score) on protocol biopsies at 1 month, 1 year, and 2 years in all randomized patients. We compared the outcomes between treatment groups and analyzed the impact of previous rejection on the chronic changes. We randomized 122 patients, 62 to sirolimus and 60 to tacrolimus. The 1-year biopsy was performed in 54 patients (90%) of the tacrolimus group and 56 patients (90%) of the sirolimus group. The proportion of biopsies with IFTA more than or equal to 2 and the Total Score more than 2 increased over the 2 years but were not different between the study groups at any time point. On the 1-year biopsy, there was more IFTA, and the fraction with Total Score more than 2 was higher in the tacrolimus group with previous rejection. In the cohort without rejection, there was a significant progression of the IFTA and Total Score between 1 and 2 years in both the sirolimus and tacrolimus groups. Conversion from tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal does not decrease the progression of chronic changes on protocol biopsies during the first 2 years even in those patients without previous acute rejection.","internal_url":"https://www.academia.edu/17591507/Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal","translated_internal_url":"","created_at":"2015-11-01T20:58:59.210-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37425114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8455148,"work_id":17591507,"tagging_user_id":37425114,"tagged_user_id":28827117,"co_author_invite_id":null,"email":"m***i@kaust.edu.sa","display_order":0,"name":"Martin Mai","title":"Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal"}],"downloadable_attachments":[],"slug":"Impact_of_Early_Conversion_From_Tacrolimus_to_Sirolimus_on_Chronic_Allograft_Changes_in_Kidney_Recipients_on_Rapid_Steroid_Withdrawal","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":37425114,"first_name":"Hani","middle_initials":"","last_name":"Wadei","page_name":"HaniWadei","domain_name":"independent","created_at":"2015-11-01T20:58:21.808-08:00","display_name":"Hani Wadei","url":"https://independent.academia.edu/HaniWadei"},"attachments":[],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus"}],"urls":[]}, dispatcherData: dispatcherData }); 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