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value="women" > Women </option> <option value="world" > World </option> <option value="wevj" > World Electric Vehicle Journal (WEVJ) </option> <option value="youth" > Youth </option> <option value="zoonoticdis" > Zoonotic Diseases </option> </select> </div> <div class="large-2 medium-2 small-6 columns "> <div class=""> <div class="search-input-label">Article Type</div> </div> <select id="article_type" tabindex="4" name="article_type" class="chosen-select"> <option value="">All Article Types</option> <option value="research-article">Article</option> <option value="review-article">Review</option> <option value="rapid-communication">Communication</option> <option value="editorial">Editorial</option> <option value="abstract">Abstract</option> <option value="book-review">Book Review</option> <option value="brief-communication">Brief Communication</option> <option value="brief-report">Brief Report</option> <option value="case-report">Case Report</option> <option 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type="hidden" id="refine_page_count" name="page_count" value="50"> <input type="hidden" id="refine_journal" name="journal" value="jpbi"> <span id="refine_exclude_field" style="display: none;"></span> <div class="content__container " > <div class="custom-accordion-for-small-screen-link " > <h2>Saved Queries</h2> </div> <div class="target-item custom-accordion-for-small-screen-content show-for-medium-up"> <div class="generic-item refind-item-wrap no-border last-item no-padding-top"> <a class="bold" href="/user/login">Sign in</a> to use this feature. </div> </div> </div> <div class="content__container " > <div class="custom-accordion-for-small-screen-link " data-callback=processResetAllVisibility> <h2> Search Filter <a href="#" class="remove-refines remove-refines-all link--red right">Reset All</a> </h2> </div> <div class="target-item custom-accordion-for-small-screen-content show-for-medium-up"> <div class="generic-item refind-item-wrap no-border no-padding-top"> <h3>Years</h3> 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dedicated information section to learn more about MDPI. </p> <a target="_blank" href="/authors" class="button button--color button--full-width"> Get Information </a> </div> </div> <a class="close-reveal-modal" aria-label="Close"> <i class="material-icons">clear</i> </a> </div> </div> <div class="middle-column__main "> <link rel="stylesheet" href="https://pub.mdpi-res.com/assets/css/jquery-ui-1.10.4.custom.min.css?80647d88647bf347?1732286508"> <div class="content__container content__container--overflow-initial"> <h1> Search Results (3) </h1> <p> Search Parameters: <br/> <b>Journal</b> = JPBI </p> <div class="article-listing"> <form id="exportArticles" method="post" action="/export"> <input type="hidden" name="_token" value="cHjrSGi2qzAOt5gAxl2jimPb3VFM_WBvtWhL-_JA7x4"> <input type="hidden" name="sort" value="pubdate"> <input type="hidden" name="page_count" value="50"> <input type="hidden" name="year_from" value="1996"> <input type="hidden" name="year_to" value="2024"> <input type="hidden" name="journal" value="jpbi"> <script type="text/x-mathjax-config"> MathJax.Hub.Config({ "HTML-CSS": { availableFonts: ["TeX"], preferredFonts: "TeX", webFont:"TeX", imageFont:"TeX", undefinedFamily:"'Arial Unicode MS',serif", scale: 80, linebreaks: { automatic: true, width: "container" } }, "TeX": { extensions: ["noErrors.js"], noErrors: { inlineDelimiters: ["",""], multiLine: true, style: { "font-size": "90%", "text-align": "left", "color": "black", "padding": "1px 3px", "border": "1px solid" } } } }); MathJax.Hub.Register.StartupHook("End",function () { $(".art-abstract").css("display", "block"); }); </script> <script type="text/javascript" src="https://pub.mdpi-res.com/bundles/mathjax/MathJax.js?config=TeX-AMS-MML_HTMLorMML"></script> <div class="ui-tabs-panel article-listing" style="padding: 0px;border: 0;"> <div class="header listing-header"> <div class="listing-display-options1" id="selectView"> <div class="row generic-item indented1"> <input type="hidden" name="sort" value="pubdate"> <input type="hidden" name="page_count" value="50"> <input type="hidden" name="year_from" value="1996"> <input type="hidden" name="year_to" value="2024"> <input type="hidden" name="journal" value="jpbi"> <div class="large-4 medium-4 small-12 columns"> <div class="listing-option__label"> Order results </div> <div class="listing-option__options"> <select class="chosen-select" name="sort" onchange="$('#articleBrowserView').click(); return false;"> <option value="bibliographic" >Bibliographic</option> <option value="relevance" >Relevance</option> <option value="pubdate" selected = 'selected'>Publication Date</option> <option value="reference_citedby_number_max" >Times Cited</option> <option value="articles_stats_art_view_page" >Times Viewed</option> </select> </div> </div> <div class="large-4 medium-4 small-12 columns"> <div class="listing-option__label"> Result details </div> <div class="listing-option__options"> <select class="chosen-select" name="view" onchange="$('#articleBrowserView').click(); return false;"> <option value="default" selected="selected">Normal</option> <option value="abstract" >Extended</option> <option value="compact" >Compact</option> </select> </div> </div> <div class="large-4 medium-4 small-12 columns"> <div class="listing-option__label"> Results per page </div> <div class="listing-option__options"> <select class="chosen-select" name="page_count" onchange="$('#articleBrowserView').click(); return false;"> <option value="10"> 10 </option> <option value="50" selected="selected"> 50 </option> <option value="100"> 100 </option> <option value="200"> 200 </option> </select> </div> </div> <div class="listing-apply" style="display: none;"> <input type="submit" value="Apply Settings" class="articleBrowserSubmit" data-url="https://www.mdpi.com/search?journal=jpbi&sort=pubdate" id="articleBrowserView"> </div> </div> </div> <div class="row listing-select-options1"> <div class="columns small-12"> <div class="select 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class="label articletype">Editorial</span></div> <a class="title-link" href="/2813-9380/1/1/3"><i>Journal of Pharmaceutical and BioTech Industry</i>: A New Open Access Journal</a> <div class="authors"> by <span class="inlineblock "><strong>Ecevit Bilgili</strong></span> </div> <div class="color-grey-dark"> <em>J. Pharm. BioTech Ind.</em> <b>2024</b>, <em>1</em>(1), 18-19; <a href="https://doi.org/10.3390/jpbi1010003">https://doi.org/10.3390/jpbi1010003</a> - 12 Sep 2024 </div> Viewed by 896 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> The pharmaceutical and biotechnology industry continues to be one of the most important industry sectors for various reasons [...] <a href="/2813-9380/1/1/3">Full article</a> </div> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1443330" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 2769 KiB </span> <a href="/2813-9380/1/1/2/pdf?version=1721983516" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Preparation of Indomethacin Co-Crystals; Comparison of XRD, THz, and FT-IR Spectral Analyses; and Enhancement of Solubility" data-journal="jpbi"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2813-9380/1/1/2">Preparation of Indomethacin Co-Crystals; Comparison of XRD, THz, and FT-IR Spectral Analyses; and Enhancement of Solubility</a> <div class="authors"> by <span class="inlineblock "><strong>Chih-Chin Hsu</strong>, </span><span class="inlineblock "><strong>Chih-Tse Hung</strong>, </span><span class="inlineblock "><strong>Ya-Hsuan Lin</strong>, </span><span class="inlineblock "><strong>Hua-Jeng Tsai</strong>, </span><span class="inlineblock "><strong>Po-Chih Hu</strong>, </span><span class="inlineblock "><strong>Yi-Ping Lin</strong>, </span><span class="inlineblock "><strong>Jyh-Chern Chen</strong>, </span><span class="inlineblock "><strong>Shen-Fu Hsu</strong> and </span><span class="inlineblock "><strong>Hsyue-Jen Hsieh</strong></span> </div> <div class="color-grey-dark"> <em>J. Pharm. BioTech Ind.</em> <b>2024</b>, <em>1</em>(1), 2-17; <a href="https://doi.org/10.3390/jpbi1010002">https://doi.org/10.3390/jpbi1010002</a> - 26 Jul 2024 </div> Viewed by 1020 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Background: The aqueous solubility of indomethacin, a poorly water-soluble anti-inflammatory drug, was enhanced by co-crystallization with co-formers. The co-crystals were characterized and compared by an X-ray diffraction (XRD) analysis, terahertz (THz) spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. Methods: Indomethacin co-crystals with either <a href="#" data-counterslink = "https://www.mdpi.com/2813-9380/1/1/2/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Background: The aqueous solubility of indomethacin, a poorly water-soluble anti-inflammatory drug, was enhanced by co-crystallization with co-formers. The co-crystals were characterized and compared by an X-ray diffraction (XRD) analysis, terahertz (THz) spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. Methods: Indomethacin co-crystals with either amides (saccharin, nicotine amide, and urea) or amino acids (lysine and histidine) as co-formers were prepared through the solvent evaporation method. The co-crystals were characterized by XRD, THz, and FT-IR analyses, followed by solubility tests to examine the solubility enhancement. Results: Both the XRD and THz analyses were capable of distinguishing co-crystals from physical mixtures; however, the THz spectra were relatively simpler and clearer than the XRD analysis. Furthermore, the solubility of indomethacin was successfully increased by two to three times that of pure indomethacin after co-crystallization with the above five co-formers. Conclusion: Five kinds of indomethacin co-crystals (with enhanced solubility) were successfully prepared and confirmed by the three spectroscopy techniques, XRD, THz, and FT-IR. The identification of co-crystals was achieved by a THz analysis, giving relatively simpler and clearer spectra with less noise. Hence, in addition to an XRD analysis, a THz analysis (a non-destructive, non-ionizing radiative, and relatively rapid measurement technique which is convenient and safe to use) is a good alternative method to characterize co-crystals. <a href="/2813-9380/1/1/2">Full article</a> </div> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2813-9380/1/1/2/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1443330"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1443330"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1443330" data-cycle-prev="#prev1443330" data-cycle-progressive="#images1443330" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1443330-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-ag-550.jpg?1730449877" alt="" style="border: 0;"><p>Graphical abstract</p></div><script id="images1443330" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1443330-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g001-550.jpg?1721983586'><p>Figure 1</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1443330-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g002-550.jpg?1721983588'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1443330-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g003-550.jpg?1721983591'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1443330-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g004-550.jpg?1721983594'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1443330-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g005-550.jpg?1721983596'><p>Figure 5</p></div></script></div></div><div id="article-1443330-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-ag-550.jpg?1730449877" title=" <strong>Graphical abstract</strong><br/><strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g001-550.jpg?1721983586" title=" <strong>Figure 1</strong><br/> <p>Indomethacin/saccharin (IND/SAC) system. (<b>a</b>) Powder XRD patterns, (<b>b</b>) terahertz (THz) absorption spectra, and (<b>c</b>) FT-IR absorption spectra of co-crystals of indomethacin/saccharin prepared by solvent evaporation (IND/SAC CC), physical mixture of indomethacin/saccharin (IND/SAC PM), saccharin (SAC), and indomethacin (IND).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g002-550.jpg?1721983588" title=" <strong>Figure 2</strong><br/> <p>Indomethacin/nicotinamide (IND/NIC) system. (<b>a</b>) Powder XRD patterns, (<b>b</b>) terahertz (THz) absorption spectra, and (<b>c</b>) FT-IR absorption spectra of co-crystals of indomethacin/nicotinamide prepared by solvent evaporation (IND/NIC CC), physical mixture of indomethacin/nicotinamide (IND/NIC PM), nicotinamide (NIC), and indomethacin (IND).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g003-550.jpg?1721983591" title=" <strong>Figure 3</strong><br/> <p>Indomethacin/urea (IND/U) system. (<b>a</b>) Powder XRD patterns, (<b>b</b>) terahertz (THz) absorption spectra, and (<b>c</b>) FT-IR absorption spectra of co-crystals of indomethacin/urea prepared by solvent evaporation (IND/U CC), physical mixture of indomethacin/urea (IND/U PM), urea (U), and indomethacin (IND).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g004-550.jpg?1721983594" title=" <strong>Figure 4</strong><br/> <p>Indomethacin/lysine (IND/LYS) system. (<b>a</b>) Powder XRD patterns, (<b>b</b>) terahertz (THz) absorption spectra, and (<b>c</b>) FT-IR absorption spectra of co-crystals of indomethacin/lysine prepared by solvent evaporation (IND/LYS CC), physical mixture of indomethacin/lysine (IND/LYS PM), L-lysine (LYS), and indomethacin (IND).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpbi/jpbi-01-00002/article_deploy/html/images/jpbi-01-00002-g005-550.jpg?1721983596" title=" <strong>Figure 5</strong><br/> <p>Indomethacin/histidine (IND/HIS) system. (<b>a</b>) Powder XRD patterns, (<b>b</b>) terahertz (THz) absorption spectra, and (<b>c</b>) FT-IR absorption spectra of co-crystals of indomethacin/histidine prepared by solvent evaporation (IND/HIS CC), physical mixture of indomethacin/histidine (IND/HIS PM), L-histidine (HIS), and indomethacin (IND).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2813-9380/1/1/2'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1334787" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 1 pages, 156 KiB </span> <a href="/2813-9380/1/1/1/pdf?version=1707299692" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Publisher鈥檚 Note: Journal of Pharmaceutical and BioTech Industry, a New Open Access Journal" data-journal="jpbi"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Editorial</span></div> <a class="title-link" href="/2813-9380/1/1/1">Publisher’s Note: <i>Journal of Pharmaceutical and BioTech Industry</i>, a New Open Access Journal</a> <div class="authors"> by <span class="inlineblock "><strong>Ioana Craciun</strong></span> </div> <div class="color-grey-dark"> <em>J. 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BioTech Ind.</em> <b>2024</b>, <em>1</em>(1), 1; <a href="https://doi.org/10.3390/jpbi1010001">https://doi.org/10.3390/jpbi1010001</a> - 7 Feb 2024 </div> Viewed by 1420 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> Collaborations between academia and industry serve as a powerful catalyst for scientific progress, synergizing the strengths of both sectors [...] <a href="/2813-9380/1/1/1">Full article</a> </div> </div> </div> </div> </div> <div class="row footer"> <div class="listing-select-options"> <div class="columns small-12"> <div class="select generic-item"> <a href="#" class="export-options-show export-element export-expanded"> Show export options <i class="material-icons">expand_more</i> </a> <a href="#" class="export-options-show export-element"> Show export options <i 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