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Analyze Efficacy of Immune Cell Therapies with RNAscope ISH
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id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="#address">Address Critical Questions</a> | <a href="#monitor">Monitor CAR-T Infiltration</a> | <a href="#assess">Assess CAR-T Functionality</a> | <a href="#services">Services</a> | <a href="#resources">Featured Resources</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Measure Biodistribution of Cell Therapies with Spatial Multiomics</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Developing immune cell therapies, such as CAR-T, TCR-T, CAR-NK cell, and macrophage therapies, are increasingly being used to treat solid tumors. However, detecting and quantifying these therapies in intact human tumor biopsies remains a challenge.</p><p><a href="/reagents/rnascope-ish-technology/rnascope">RNAscope</a> probes can target viral untranslated regions (UTRs) found in all CAR and TCR mRNAs, allowing for the specific detection and quantification of engineered therapeutic cells. RNAscope UTR probes can also be combined with cytokine and chemokine probes to assess immune cell recruitment and activation states in combination with immunohistochemistry (IHC) and immunofluorescent (IF) detection of cell type markers for T cells such as <a href="/t/cd3">CD3</a>, <a href="/t/cd4">CD4</a>, and <a href="/t/human-cd8-t-cell">CD8</a> to monitor cell therapies in post-treatment patient biopsies and preclinical animal models for safety and efficacy.</p><h2><strong>Highlights</strong></h2><ul><li>Visualize and quantify CAR/TCR-T cell infiltration and activation in tumor and non-tumor tissues.</li><li>Measure therapy-induced immune responses and toxicity by visualizing cytokines, T cell markers, or other cell-type markers.</li><li>Evaluate <a href="/applications/spatial-biology/rnascope-multiomics">multiomic</a> expression of other RNA and protein targets across multiple types of tissues and animal models.</li></ul></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Detect and Quantify CAR or TCR mRNA in the Tumor Microenvironment (TME)</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/reagents/detect-quantify-car-tcr-mrna.png" alt="RNAscope probe design" loading="lazy" > </div> <div><p> </p><p>RNAscope probes are designed to target the 5' or 3' UTR of the CAR vector.</p><p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-button mb-4 paragraph--view-mode--default w-100"> <div class="row"> <div class="col"> <a href="/reagents/rnascope-ish-technology/probes/custom/request-form" class="btn btn-primary" type="link" > Submit New Probe Design </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="address"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h2>Address Critical Questions in Cell Therapy</h2></div> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/critical-questions-cell-therapy.png" alt="Critical Questions in Cell Therapy " loading="lazy" > </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>New Product! RNAscope Multiomic LS Assay</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Combine up to 4 pre-conjugated antibodies with your own <a href="/search?search_type=products&keywords=antibodies&category_attr=Primary%20Antibodies">primary antibodies</a> and or available conjugated <a href="/search?search_type=products&keywords=antibodies&category_attr=Secondary%20Antibodies">secondary antibodies</a> along with CAR or TCR mRNA RNAscope probes to interrogate the tissue microenvironment.</p><p>The <a href="/reagents/rnascope-ish-technology/rnascope/fluorescent-assays/multiomic-ls">RNAscope Multiomic LS assay</a> enables highly sensitive and specific detection of both RNA and proteins in the same tissue section for a true multiomic spatial assay. <strong>The pre-conjugated TIL panel is perfect for CAR-T cell therapy assessment in preclinical tissue samples.</strong> This assay enables simultaneous detection of up to 6 total proteins and/ or RNA targets with single-cell resolution.</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/reagents/rnascope-ish-technology/rnascope/fluorescent-assays/multiomic-ls" class="btn btn-primary" type="link"> Learn More </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <a href="https://www.bio-techne.com/reagents/rnascope-ish-technology/rnascope/fluorescent-assays/multiomic-ls" title="Learn More" target="_blank" rel="noreferrer" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/multiomic-ls-fluorescent-assay.png" alt="Multiomic LS" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="monitor"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Monitor the Infiltration of CAR- and TCR-T Cells in Tissue</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>With RNAscope or <a href="/reagents/rnascope-ish-technology/basescope/manual-ls">BaseScope™</a> ISH probes designed against the 5’ or 3’ UTR from the CAR or TCR vector transcript, engineered T cells can be detected and quantified in the tumor microenvironment (TME) or any other intact tissue. The high sensitivity of the RNAscope assay enables preclinical screening for target antigen expression at the RNA level to avoid adverse effects resulting from on-target/off-tumor activity.</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/liposarcoma-infiltration.jpg" alt="liposarcoma infiltration" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="assess"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Assess CAR- or TCR-T Cell Functionality and Activation State</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>The multiplexing capabilities of the chromogenic and fluorescent RNAscope ISH assays enable simultaneous detection of multiple targets on the same slide. CAR or TCR vector transcripts can be co-stained with <em>IFN</em><em>G</em> and <em>GZMB</em> to assess activation state, or with cell-type markers such as CD3 and CD8 to discern engineered CAR- or TCR-T cells from endogenous T cells.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/reagents/rnascope-infiltration.png" alt="RNAscope infiltration" loading="lazy" > </div> <div><p>RNAscope Multiplex Fluorescence ISH/IF assay showing <em>Granzyme B</em> and <em>IFNG</em> expression and CD3<sup>+</sup> T cell infiltration in a BCMA<sup>+</sup> xenograft tumor treated with anti-BCMA CAR-T cells.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><a name="services"></a><h2>Interested in Services?</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h3><strong>RNAscope Professional Assay Services</strong></h3><p>Our <a href="/services/professional-assay-services-rnascope">Professional Assay Services</a> offer you direct access to the developers of RNAscope <em>in situ</em> hybridization (ISH) technology. Accelerate your journey in target validation, preclinical, and clinical development with our promise to provide consistent and trustworthy data to drive your projects forward. </p><p> </p><p> </p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="https://info.bio-techne.com/WEB-ACD-2023-07-PAS-Lead-Capture-Assay-Services-7398_01-LP-Main.html" class="btn btn-primary" type="link"> Free Project Consultation </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <a href="https://info.bio-techne.com/WEB-ACD-2023-07-PAS-Lead-Capture-Assay-Services-7398_01-LP-Main.html" title="Free Project Consultation" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/applications/rnascope-professional-assay-services.png" alt="Illustration of the GCLP-compliant RNAscope assay services available from Bio-Techne" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="resources"></a></p><h2>Featured Resources</h2></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/literature/preclinical-car-t-cell-target-safety-analysis" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/literature/car-t-rnascope-app-note.jpg" alt="Preclinical CAR-T cell target safety, biodistribution, and tumor infiltration analysis using the RNAscope ISH assay" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/preclinical-car-t-cell-target-safety-analysis" > <h3 class="card_title_htag"> <div><h3>Preclinical CAR-T cell analysis using the RNAscope ISH assay </h3></div> </h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/preclinical-car-t-cell-target-safety-analysis" > Get Application Note </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.youtube.com/watch?v=dyxNJqasYFA" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/webinars-icon-light-blue.png" alt="Webinars icon " loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://www.youtube.com/watch?v=dyxNJqasYFA" > <h3 class="card_title_htag"> <div><h3>RNAscope for CAR-T Cell Therapy Webinar</h3></div> </h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="https://www.youtube.com/watch?v=dyxNJqasYFA" > Watch Webinar </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://resources.bio-techne.com/bio-techne-assets/docs/pdfs/flyers/cell-therapy-flyer.pdf" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/therapeutic-manufacturing/cell-therapy-rnascope-in-situ-hybridization-flyer.jpg" alt="T-Cell Cell Therapy RNAscope Flyer" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://resources.bio-techne.com/bio-techne-assets/docs/pdfs/flyers/cell-therapy-flyer.pdf" > <h3 class="card_title_htag"> <div><h3>T Cell Therapy and Trafficking and Activation Analysis Using RNAscope </h3></div> </h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="https://resources.bio-techne.com/bio-techne-assets/docs/pdfs/flyers/cell-therapy-flyer.pdf" > Download Flyer </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/banners/v8_round-black-blue-gradient-banner-1110x350.png" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h2><strong>Get Started Today. 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