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0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-97865a4b41eebf6819eddc4c76d29598fe6b0336be57e9b6cde63060c39bfa02.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 38338769; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F111276758%2FPlacental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F111276758%2FPlacental_Nutrient_Transporters_and_Maternal_Fatty_Acids_in_SGA_AGA_and_LGA_Newborns_From_Mothers_With_and_Without_Obesity%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":108858012,"identifier":"Attachment_108858012","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":111276758,"created_at":"2023-12-12T16:40:44.641-08:00","from_world_paper_id":245605203,"updated_at":"2024-11-26T05:32:02.988-08:00","_data":{"publisher":"Frontiers Media","grobid_abstract":"Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.","publication_date":"2022,3,25","publication_name":"Frontiers in Cell and Developmental Biology","grobid_abstract_attachment_id":"108858012"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [38338769]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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Metabolism by Maternal Obesity in the Human Full-Term Placenta</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="127928408" href="https://independent.academia.edu/IssakaboyeMoussa">Issa kaboye Moussa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biology of Reproduction, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta","attachmentId":69972366,"attachmentType":"pdf","work_url":"https://www.academia.edu/52964734/Modulation_of_Fatty_Acid_Transport_and_Metabolism_by_Maternal_Obesity_in_the_Human_Full_Term_Placenta","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52964734/Modulation_of_Fatty_Acid_Transport_and_Metabolism_by_Maternal_Obesity_in_the_Human_Full_Term_Placenta"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="101615679" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101615679/Modulation_of_Fatty_Acid_Transport_and_Metabolism_by_Maternal_Obesity_in_the_Human_Full_Term_Placenta1">Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1</a><div class="ds-related-work--metadata"><a 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js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101615679/Modulation_of_Fatty_Acid_Transport_and_Metabolism_by_Maternal_Obesity_in_the_Human_Full_Term_Placenta1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="91662062" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91662062/Effect_of_maternal_obesity_on_fetal_growth_and_the_expression_of_placental_fatty_acid_transporters">Effect of maternal obesity on fetal growth and the expression of placental fatty acid transporters</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="247322174" href="https://independent.academia.edu/HanLai19">Han Lai</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of clinical research in pediatric endocrinology, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">To explore the effects of maternal high-fat diet induced obesity on fetal growth and the expression of placental nutrient transporters. Maternal obesity was established in rats by 8 weeks of pre-pregnancy high-fat (HF) diet feeding, while rats in the control group were fed with normal (CON) diet. Diet induced obesity (DIO) rats and diet induced obesity resistant (DIR) rats were selected according to body weight gain over this period. After copulation, the CON rats were divided into two groups: switched to HF diet (CON-HF group) or maintained on the CON diet (CON-CON group). The DIO rats and DIR rats were maintained on the HF diet throughout pregnancy. Pregnant rats were euthanized at day 21 gestation, fetal and placental weights recorded and placental tissue collected. RT-PCR was used to determine mRNA expression of placental nutrient transporters. Protein expression was determined by Western blot. Average fetal weight of DIO dams was reduced by 6.9% and the placentas of CON-HF and ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of maternal obesity on fetal growth and the expression of placental fatty acid transporters","attachmentId":94886353,"attachmentType":"pdf","work_url":"https://www.academia.edu/91662062/Effect_of_maternal_obesity_on_fetal_growth_and_the_expression_of_placental_fatty_acid_transporters","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/91662062/Effect_of_maternal_obesity_on_fetal_growth_and_the_expression_of_placental_fatty_acid_transporters"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="56958101" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism">Effect of Maternal Obesity on Placental Lipid Metabolism</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="140659986" href="https://independent.academia.edu/HoppelCharles">Charles Hoppel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Endocrinology, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Obese women, on average, give birth to babies with high fat mass. Placental lipid metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is affected by maternal obesity is poorly understood. We hypothesized that fatty acid (FA) accumulation (esterification) is higher and FA β-oxidation (FAO) is lower in placentas from obese, compared with lean women. We assessed acylcarnitine profiles (lipid oxidation intermediates) in mother-baby-placenta triads, in addition to lipid content, and messenger RNA (mRNA)/protein expression of key regulators of FA metabolism pathways in placentas of lean and obese women with normal glucose tolerance recruited at scheduled term Cesarean delivery. In isolated trophoblasts, we measured [3H]-palmitate metabolism. Placentas of obese women had 17.5% (95% confidence interval: 6.1, 28.7%) more lipid than placentas of lean women, and higher mRNA and protein expression of FA esterification regulators (e.g., peroxisome prolif...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Maternal Obesity on Placental Lipid Metabolism","attachmentId":72090144,"attachmentType":"pdf","work_url":"https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56958101/Effect_of_Maternal_Obesity_on_Placental_Lipid_Metabolism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="53618229" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53618229/Decreased_Fatty_Acid_Transporter_FABP1_and_Increased_Isoprostanes_and_Neuroprostanes_in_the_Human_Term_Placenta_Implications_for_Inflammation_and_Birth_Weight_in_Maternal_Pre_Gestational_Obesity">Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39156954" href="https://independent.academia.edu/F%C3%A1timaSardinha">Fátima Sardinha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nutrients</p><p class="ds-related-work--abstract ds2-5-body-sm">The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by maternal obesity, which possibly affects the life-long health of the offspring. Here, we investigated placental lipid metabolism in women with pre-gestational obesity as a sole pregnancy complication and compared it to placental responses of lean women. Open profile and targeted lipidomics were used to assess placental lipids and oxidised products of docosahexaenoic (DHA) and arachidonic acid (AA), respectively, neuroprostanes and isoprostanes. Despite no overall signs of lipid accumulation, DHA and AA levels in placentas from obese women were, respectively, 2.2 and 2.5 times higher than those from lean women. Additionally, a 2-fold increase in DHA-derived neuroprostanes and a 1.7-fold increase in AA-derived isoprostanes were seen in the obese group. These c...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity","attachmentId":70379518,"attachmentType":"pdf","work_url":"https://www.academia.edu/53618229/Decreased_Fatty_Acid_Transporter_FABP1_and_Increased_Isoprostanes_and_Neuroprostanes_in_the_Human_Term_Placenta_Implications_for_Inflammation_and_Birth_Weight_in_Maternal_Pre_Gestational_Obesity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53618229/Decreased_Fatty_Acid_Transporter_FABP1_and_Increased_Isoprostanes_and_Neuroprostanes_in_the_Human_Term_Placenta_Implications_for_Inflammation_and_Birth_Weight_in_Maternal_Pre_Gestational_Obesity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="75093854" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels">Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="125459641" href="https://independent.academia.edu/FernandaAlvarado74">Fernanda Alvarado</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Placenta, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Placentas of obese women have higher lipid content compared to lean women. We have previously shown that supplementation of overweight and obese women with omega-3 fatty acids decreases placental esterification pathways and total lipid content in a mid-western population (Ohio). We hypothesized that placental lipid accumulation and inflammation would be similar between lean and obese women living in a region of high omega-3 intake, such as Hawaii. Fifty-five healthy, normal glucose tolerant women from Honolulu Hawaii, dichotomized based on pre-pregnancy BMI into lean (BMI &lt;25 kg/m, n = 29) and obese (BMI &gt;30 kg/m, n = 26), were recruited at scheduled term cesarean delivery. Maternal plasma DHA levels were analyzed by mass spectrometry. Expression of key genes involved in fatty acid oxidation and esterification were measured in placental tissue using qPCR. Total lipids were extracted from placental tissue via the Folch method. TNF-α concentration was measured by enzyme-linked i...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels","attachmentId":83002000,"attachmentType":"pdf","work_url":"https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/75093854/Maternal_obesity_is_not_associated_with_placental_lipid_accumulation_in_women_with_high_omega_3_fatty_acid_levels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="121007294" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121007294/Placental_fatty_acid_transport_in_maternal_obesity">Placental fatty acid transport in maternal obesity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="285647149" href="https://unimi.academia.edu/ChiaraMand%C3%B2">Chiara Mandò</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Developmental Origins of Health and Disease, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal obesity is associated with a specific proinflammatory, endocrine and metabolic phenotype that may lead to higher supply of nutrients to the feto-placental unit and to excessive fetal fat accumulation. In particular, obesity may influence placental fatty acid (FA) transport in several ways, leading to increased diffusion driving force across the placenta, and to altered placental development, size and exchange surface area. Animal models show that maternal obesity is associated with increased expression of specific FA carriers and inflammatory signaling molecules in placental cotyledonary tissue, resulting in enhanced lipid transfer across the placenta, dislipidemia, fat accumulation and possibly altered development in fetuses. Cell culture experiments confirmed that inflammatory molecules, adipokines and FA, all significantly altered in obesity, are important regulators of placental lipid ex...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placental fatty acid transport in maternal obesity","attachmentId":115988251,"attachmentType":"pdf","work_url":"https://www.academia.edu/121007294/Placental_fatty_acid_transport_in_maternal_obesity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/121007294/Placental_fatty_acid_transport_in_maternal_obesity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="104351068" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104351068/Maternal_Fatty_Acid_Metabolism_in_Pregnancy_and_Its_Consequences_in_the_Feto_Placental_Development">Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43746830" href="https://independent.academia.edu/AsimDuttaroy">Asim K Duttaroy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Physiology, 2022</p><p class="ds-related-work--abstract ds2-5-body-sm">During pregnancy, maternal plasma fatty acids are critically required for cell growth and development, cell signaling, and the development of critical structural and functional aspects of the feto-placental unit. In addition, the fatty acids modulate the early stages of placental development by regulating angiogenesis in the first-trimester human placenta. Preferential transport of maternal plasma long-chain polyunsaturated fatty acids during the third trimester is critical for optimal fetal brain development. Maternal status such as obesity, diabetes, and dietary intakes may affect the functional changes in lipid metabolic processes in maternal-fetal lipid transport and metabolism. Fatty acids traverse the placental membranes via several plasma membrane fatty acid transport/binding proteins (FAT, FATP, p-FABPpm, and FFARs) and cytoplasmic fatty acid-binding proteins (FABPs). This review discusses the maternal metabolism of fatty acids and their effects on early placentation, placen...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development","attachmentId":104105442,"attachmentType":"pdf","work_url":"https://www.academia.edu/104351068/Maternal_Fatty_Acid_Metabolism_in_Pregnancy_and_Its_Consequences_in_the_Feto_Placental_Development","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/104351068/Maternal_Fatty_Acid_Metabolism_in_Pregnancy_and_Its_Consequences_in_the_Feto_Placental_Development"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="105183446" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105183446/Altered_maternal_and_placental_lipid_metabolism_and_fetal_fat_development_in_obesity_Current_knowledge_and_advances_in_non_invasive_assessment">Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="142281124" href="https://independent.academia.edu/SamanthaRobbins6">Samantha Bedell</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Placenta, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk. The placenta plays a critical role in mediating nutritional signals between the fetus and the mother. As obesity rates in women of reproductive age continue to increase, it is becoming evident that inclusion of new technologies that allow for a better understanding of early changes in placental lipid transport and metabolism, non-invasively in maternal circulation, maternal tissues, placenta, ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment","attachmentId":104707041,"attachmentType":"pdf","work_url":"https://www.academia.edu/105183446/Altered_maternal_and_placental_lipid_metabolism_and_fetal_fat_development_in_obesity_Current_knowledge_and_advances_in_non_invasive_assessment","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105183446/Altered_maternal_and_placental_lipid_metabolism_and_fetal_fat_development_in_obesity_Current_knowledge_and_advances_in_non_invasive_assessment"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="57722205" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57722205/Placental_Fatty_Acid_Transfer_A_Key_Factor_in_Fetal_Growth">Placental Fatty Acid Transfer: A Key Factor in Fetal Growth</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="72283226" href="https://independent.academia.edu/AntonioG%C3%A1zquez">Antonio Gázquez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annals of Nutrition and Metabolism, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placental Fatty Acid Transfer: A Key Factor in Fetal Growth","attachmentId":72483748,"attachmentType":"pdf","work_url":"https://www.academia.edu/57722205/Placental_Fatty_Acid_Transfer_A_Key_Factor_in_Fetal_Growth","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57722205/Placental_Fatty_Acid_Transfer_A_Key_Factor_in_Fetal_Growth"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":108858012,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":108858012,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_108858012" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="96191722" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96191722/Obesity_downregulates_lipid_metabolism_genes_in_first_trimester_placenta">Obesity downregulates lipid metabolism genes in first trimester placenta</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29754284" href="https://independent.academia.edu/WhiteKatharine">Katharine White</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scientific Reports</p><div 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="64462885" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64462885/Influence_of_Maternal_Obesity_and_Gestational_Weight_Gain_on_Maternal_and_Foetal_Lipid_Profile">Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31415387" href="https://independent.academia.edu/LucillaRav%C3%A0">Lucilla Ravà</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nutrients, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Influence of Maternal Obesity and 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development","attachmentId":104105438,"attachmentType":"pdf","work_url":"https://www.academia.edu/104351058/Maternal_dietary_fatty_acids_and_their_roles_in_human_placental_development","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/104351058/Maternal_dietary_fatty_acids_and_their_roles_in_human_placental_development"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="87806935" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women">Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10666367" href="https://metrohealth.academia.edu/maricelahaghiac">maricela haghiac</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American journal of clinical nutrition, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women","attachmentId":91920756,"attachmentType":"pdf","work_url":"https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/87806935/Effect_of_%CF%89_3_supplementation_on_placental_lipid_metabolism_in_overweight_and_obese_women"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="7465853" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title 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