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class="WebinarSection-InfoText">Date: Nov 14, 2024</p></div><div class="WebinarSection-InfoItem" data-testid="webinar-section-duration"><span data-component="icon" data-name="StopWatch" class="WebinarSection-Icon" 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class="WebinarSection-InfoText">Duration: 15 Min</p></div></div><div class="GatingSection-GatingControls"><div class="GatingSection-ControlButtons"><div class="GatingSection-GatingButton"><a data-component="button" data-testid="gatedEcomButton" class="Button Button_size_medium Button_variant_primaryFilled" href="/sponsored-content/evaluation-of-a-new-multimodal-anion-exchange-resin-for-emerging-biotherapeutic-process-challenges" target="_blank" data-discover="true"><span class="Button-ContentWrapper">WATCH NOW</span></a></div><div data-module="ecommerce-login" class="LoginButton"><p class="LoginButton-Description">Already have an account?</p><button class="LoginButton-Button">Log in now.</button></div></div></div></div><div data-component="sponsored" class="Sponsored ArticleBase-Sponsor"><div><p class="Sponsored-Text" data-testid="sponsored-text">Sponsored by Bio-Rad Laboratories</p></div></div><div class="ArticleBase-BodyContent ArticleBase-BodyContent_Webinar" data-testid="article-base-body-content"><div data-module="content" class="ContentModule-Wrapper"><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><span class="ContentText-BodyTextChunk ContentText-BodyTextChunk_bold">This webcast features: </span></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Michael Rauscher, MS, </span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><span class="ContentText-BodyTextChunk ContentText-BodyTextChunk_italic">associate principal scientist, process R&D enabling technologies, </span></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Merck & Co., Inc.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Multimodal chromatography has a history of providing value for biopharmaceutical separations. Ligands that enable binding based on both charge and hydrophobic interactions provide more opportunity for effective separation of multiple product- and process-related impurities. However, more diverse protein therapeutics and evolving expression systems present separation challenges that may not be easily addressed by commercially available multimodal resins.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">As an alternative to current multimodal anion exchange (MMAEX) resins with quaternary ammonium groups, Bio-Rad’s new Nuvia wPrime 2A Resin offering provides MMAEX functionality with a weak anion exchanger.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">This webinar will discuss several molecules that were prioritized for high-throughput evaluation of Nuvia wPrime 2A Resin, including an IgG1 monoclonal antibody (mAb), IgG4 mAb, and a bispecific antibody (bsAb), with extra focus placed on proteins with low isoelectric points (pI) and known strong binding to alternative MMAEX resins.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">High-throughput screening in flowthrough mode was performed to assess product binding across a broad operating space. One resin was scaled up and further evaluated using miniature columns to assess impurity removal. Results indicate strong aggregate and host cell protein clearance in flowthrough mode across a range of conditions, including effective removal of some high-risk host cell proteins. Compared to MMAEX resins with Q functionality, low pI proteins bound less, allowing higher yields. Moving forward, Nuvia wPrime 2A Resin can be a promising polishing option for diverse protein therapeutics, with protein properties guiding experimental design.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Key Takeaways:</span></p><div data-component="basic-list" class="BasicList BasicList_nestedLevel_0 BasicList_variant_unordered BasicList_limited"><ul data-testid="basic-list-unordered" class="BasicList-UnorderedList"><li><div class="BasicList-ListItem BasicList-ListItem_variant_unordered"><span data-component="icon" data-name="Circle" class="BasicList-ListIcon BasicList-ListIcon_variant_unordered" style="mask-image:url("data:image/svg+xml,%3csvg%20viewBox='0%200%2024%2024'%20aria-hidden='true'%20focusable='false'%20role='img'%20xml:space='preserve'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20fill='currentColor'%20height='100%25'%20width='10'%3e%3ccircle%20cx='12'%20cy='12'%20r='11.5'%20fill='white'%20stroke='%230b0b0b'%3e%3c/circle%3e%3c/svg%3e");-webkit-mask-image:url("data:image/svg+xml,%3csvg%20viewBox='0%200%2024%2024'%20aria-hidden='true'%20focusable='false'%20role='img'%20xml:space='preserve'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20fill='currentColor'%20height='100%25'%20width='10'%3e%3ccircle%20cx='12'%20cy='12'%20r='11.5'%20fill='white'%20stroke='%230b0b0b'%3e%3c/circle%3e%3c/svg%3e");mask-repeat:no-repeat;-webkit-mask-repeat:no-repeat;-webkit-mask-position:center;-webkit-mask-size:contain"></span><div class="BasicList-Item"><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">The ability to modulate the resin's charge state provided a wide‑design space.</span></p></div></div></li><li><div class="BasicList-ListItem BasicList-ListItem_variant_unordered"><span data-component="icon" data-name="Circle" class="BasicList-ListIcon BasicList-ListIcon_variant_unordered" style="mask-image:url("data:image/svg+xml,%3csvg%20viewBox='0%200%2024%2024'%20aria-hidden='true'%20focusable='false'%20role='img'%20xml:space='preserve'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20fill='currentColor'%20height='100%25'%20width='10'%3e%3ccircle%20cx='12'%20cy='12'%20r='11.5'%20fill='white'%20stroke='%230b0b0b'%3e%3c/circle%3e%3c/svg%3e");-webkit-mask-image:url("data:image/svg+xml,%3csvg%20viewBox='0%200%2024%2024'%20aria-hidden='true'%20focusable='false'%20role='img'%20xml:space='preserve'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20fill='currentColor'%20height='100%25'%20width='10'%3e%3ccircle%20cx='12'%20cy='12'%20r='11.5'%20fill='white'%20stroke='%230b0b0b'%3e%3c/circle%3e%3c/svg%3e");mask-repeat:no-repeat;-webkit-mask-repeat:no-repeat;-webkit-mask-position:center;-webkit-mask-size:contain"></span><div class="BasicList-Item"><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Screening results showed improved yields and reductions in impurities compared to traditional strong ion exchange and strong AEX‑HIC resins.</span></p></div></div></li></ul></div><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><br/></p></div></div><div class="SocialShare"><div data-component="social-share" class="SocialShare SocialShare_variant_button ArticleBase-SocialShare ArticleBase-SocialShare_second"><a target="_blank" rel="noreferrer" aria-label="Linkedin" href="https://www.linkedin.com/sharing/share-offsite/?url=https://www.bioprocessintl.com/sponsored-content/evaluation-of-a-new-multimodal-anion-exchange-resin-for-emerging-biotherapeutic-process-challenges"><span class="SocialShare-IconWrapper SocialShare-IconWrapper_variant_button"><span data-component="icon" data-name="Linkedin" class="SocialShare-Icon 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Challenges\",\"authoredBy\",\"authoredOn\",\"oldUrl\",\"readTime\",\"panelsModule\",\"newsletterSignUpPromo\",{\"_104\":968,\"_857\":969,\"_970\":971,\"_858\":544,\"_204\":207,\"_972\":973},\"Subscribe to receive our monthly print or digital publication\",\"Join our 70,000+ readers. And yes, it's completely free.\",\"newsletterId\",\"blt78128aabb2e0dd70\",\"mode\",\"dark\",\"resourcesModule\",\"embedModule\",\"socialShare\",[978,980,982],{\"_86\":87,\"_58\":979},\"https://www.linkedin.com/sharing/share-offsite/?url=https://www.bioprocessintl.com/sponsored-content/evaluation-of-a-new-multimodal-anion-exchange-resin-for-emerging-biotherapeutic-process-challenges\",{\"_86\":90,\"_58\":981},\"http://www.twitter.com/intent/tweet?url=https://www.bioprocessintl.com/sponsored-content/evaluation-of-a-new-multimodal-anion-exchange-resin-for-emerging-biotherapeutic-process-challenges\",{\"_86\":983,\"_58\":984},\"Email\",\"mailto:?subject=Evaluation of a New Multimodal Anion Exchange Resin for Emerging Biotherapeutic Process Challenges\u0026body=I%20thought%20the%20following%20from%20BioProcess%20International%20might%20interest%20you.%0D%0A%0D%0A%20Evaluation%20of%20a%20New%20Multimodal%20Anion%20Exchange%20Resin%20for%20Emerging%20Biotherapeutic%20Process%20Challenges%0D%0Ahttps%3A%2F%2Fwww.bioprocessintl.com%2Fsponsored-content%2Fevaluation-of-a-new-multimodal-anion-exchange-resin-for-emerging-biotherapeutic-process-challenges\",\"publishedDate\",\"2024-11-14T17:19:24.000Z\",\"keywords\",[],\"atAGlance\",[],\"bodyJson\",[993,1017,1022,1026,1031,1036,1038,1043,1045,1050,1068],{\"_86\":994,\"_995\":996,\"_999\":1000},\"paragraph\",\"attrs\",{\"_997\":998},\"textAlign\",\"left\",\"content\",[1001,1008,1010,1015],{\"_86\":1002,\"_1003\":1004,\"_1002\":1007},\"text\",\"marks\",[1005],{\"_86\":1006},\"bold\",\"This webcast features: \",{\"_86\":1002,\"_1002\":1009},\"Michael Rauscher, MS, \",{\"_86\":1002,\"_1003\":1011,\"_1002\":1014},[1012],{\"_86\":1013},\"italic\",\"associate principal scientist, process R\u0026D enabling technologies, \",{\"_86\":1002,\"_1002\":1016},\"Merck \u0026 Co., Inc.\",{\"_86\":994,\"_995\":1018,\"_999\":1019},{\"_997\":998},[1020],{\"_86\":1002,\"_1002\":1021},\"Multimodal chromatography has a history of providing value for biopharmaceutical separations. Ligands that enable binding based on both charge and hydrophobic interactions provide more opportunity for effective separation of multiple product- and process-related impurities. However, more diverse protein therapeutics and evolving expression systems present separation challenges that may not be easily addressed by commercially available multimodal resins.\",{\"_86\":1023,\"_1024\":1025},\"ad\",\"pos\",\"300_1v_article\",{\"_86\":994,\"_995\":1027,\"_999\":1028},{\"_997\":998},[1029],{\"_86\":1002,\"_1002\":1030},\"As an alternative to current multimodal anion exchange (MMAEX) resins with quaternary ammonium groups, Bio-Rad’s new Nuvia wPrime 2A Resin offering provides MMAEX functionality with a weak anion exchanger.\",{\"_86\":994,\"_995\":1032,\"_999\":1033},{\"_997\":998},[1034],{\"_86\":1002,\"_1002\":1035},\"This webinar will discuss several molecules that were prioritized for high-throughput evaluation of Nuvia wPrime 2A Resin, including an IgG1 monoclonal antibody (mAb), IgG4 mAb, and a bispecific antibody (bsAb), with extra focus placed on proteins with low isoelectric points (pI) and known strong binding to alternative MMAEX resins.\",{\"_86\":1023,\"_1024\":1037},\"native_1v\",{\"_86\":994,\"_995\":1039,\"_999\":1040},{\"_997\":998},[1041],{\"_86\":1002,\"_1002\":1042},\"High-throughput screening in flowthrough mode was performed to assess product binding across a broad operating space. 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