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id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">2291</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (117)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (1289)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Bone Remodeling/drug effects</label> </div> <div 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sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" 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class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Lam W</b>, Yao Y, Tang C, Wang Y, Yuan Q, Peng L. Bifunctional mesoporous HMUiO-66-NH<sub>2</sub> nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122872. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383779' target='_blank'>39383779</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>10.1016/j.biomaterials.2024.122872</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122872','39383779', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.biomaterials.2024.122872" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontal bone defects represent an irreversible consequence of periodontitis associated with reactive oxygen species (ROS). However, indiscriminate removal of ROS proves to be counterproductive for tissue repair and insufficient for addressing existing bone defects. In the treatment of periodontitis, it is crucial to rationally alleviate local ROS while simultaneously promoting bone regeneration. In this study, Zr-based large-pore hierarchical mesoporous metal-organic framework (MOF) nanoparticles (NPs) HMUiO-66-NH2 were successfully proposed as bifunctional nanomaterials for bone regeneration and ROS scavenging in periodontitis therapy. HMUiO-66-NH2 NPs demonstrated outstanding biocompatibility both in vitro and in vivo. Significantly, these NPs enhanced the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) under normal and high ROS conditions, upregulating osteogenic gene expression and mitigating oxidative stress. Furthermore, in vivo imaging revealed a gradual degradation of HMUiO-66-NH2 NPs in periodontal tissues. Local injection of HMUiO-66-NH2 effectively reduced bone defects and ROS levels in periodontitis-induced C57BL/6 mice. RNA sequencing highlighted that differentially expressed genes (DEGs) are predominantly involved in bone tissue development, with notable upregulation in Wnt and TGF-β signaling pathways. In conclusion, HMUiO-66-NH2 exhibits dual functionality in alleviating oxidative stress and promoting bone repair, positioning it as an effective strategy against bone resorption in oxidative stress-related periodontitis. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bifunctional+nanomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bifunctional nanomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone regeneration</a></li><li><a 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<b>Tsai JN</b>, Jordan M, Lee H, Leder BZ. One versus 2 years of alendronate following denosumab: the CARD extension. <em class='incite-journal-name' onclick='ShowInCiteJournal(169341);'>Osteoporos Int</em> 2024;<b>35</b>:2225-2230. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39112628' target='_blank'>39112628</a> DOI: <a href='https://dx.doi.org/10.1007/s00198-024-07213-2' target='_blank'>10.1007/s00198-024-07213-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00198-024-07213-2','39112628', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00198-024-07213-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169341);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/osin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1007/s00198-024-07213-2" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">When denosumab is discontinued, antiresorptive therapy is critical to reduce high-turnover bone loss. The ideal duration of antiresorptive therapy after denosumab is uncertain. This study demonstrates that both 1 and 2 years of alendronate maintained bone density gains achieved with 1 year of denosumab. </div><div class="abstract-label">BACKGROUND</div><div class="abstract-content">When denosumab is discontinued, antiresorptive therapy is critical to attenuate high-turnover bone loss. The ideal choice and duration of antiresorptive therapy are not yet defined, however. In the Comparison of Alendronate or Raloxifene following Denosumab (CARD) study, we demonstrated that 12 months of alendronate was better able to maintain the bone mineral density (BMD) gains achieved with 12 months of denosumab versus 12 months of raloxifene. In this extension, we wished to determine if 12 months of alendronate would be sufficient in maintaining these denosumab-induced BMD gains. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In the CARD study, postmenopausal osteoporotic women aged 60-79 at high fracture risk received 12 months of denosumab 60-mg SC every 6 months followed by 12 months of either alendronate 70 mg weekly (N = 26) or raloxifene (N = 25). All subjects in the alendronate arm were then offered participation in a 1-year extension in which they were randomized to continue alendronate for an additional 12 months (N = 10) or to receive calcium and vitamin D alone (N = 8). The primary outcome was change in spine BMD between months 24 and 36. Exploratory endpoints included changes in areal BMD (aBMD) at other anatomic sites as well as changes in serum bone turnover markers. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The CARD study demonstrated the effectiveness of 12 months alendronate in preserving denosumab-induced BMD gains. In the extension, aBMD was maintained at the spine, total hip, and femoral neck in both those randomized to an additional year of alendronate and those randomized to calcium/vitamin D alone. We did, however, observe a transient comparative decrease between months 24-30 in the calcium/vitamin D group at the total hip (P = 0.008) and femoral neck (P = 0.040). At the end of 24 months of the CARD study, bone turnover markers serum c-telopeptide (CTX) and procollagen N-propeptide of type I collagen (PINP) were suppressed in both groups and then increased more between months 24-36 in the calcium/vitamin D group than the alendronate group (P = 0.051 for CTX, P = 0.030 for P1NP). Both CTX and PINP remained below the month 0 baseline in both groups (P < 0.05 for all comparisons). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">With the limitations of our small sample size, these data suggest that both 1 and 2 years of alendronate effectively maintain BMD gains achieved with 1 year of denosumab and prevented any rebound in bone turnover marker levels above pre-denosumab baseline. This is the first randomized trial to assess minimum duration of bisphosphonate after short-term denosumab and may be helpful to guide clinical care. Similar studies performed after longer durations of denosumab would be helpful to further define optimal management. </div><div class="abstract-label">TRIAL REGISTRATION</div><div class="abstract-content">ClinicalTrials.gov registration number: NCT03623633. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab+cessation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab cessation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronate%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronate/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronate%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronate/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Administration+Schedule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Administration Schedule</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporotic+Fractures%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporotic Fractures/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lumbar+Vertebrae%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lumbar Vertebrae/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur+Neck%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur Neck/physiopathology</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Grove-Laugesen D</b>, Ebbehoj E, Watt T, Hansen KW, Rejnmark L. Changes in bone density and microarchitecture following treatment of Graves' disease and the effects of vitamin D supplementation. A randomized clinical trial. <em class='incite-journal-name' onclick='ShowInCiteJournal(169341);'>Osteoporos Int</em> 2024;<b>35</b>:2153-2164. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39264438' target='_blank'>39264438</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579043' target='_blank'>PMC11579043</a> DOI: <a href='https://dx.doi.org/10.1007/s00198-024-07241-y' target='_blank'>10.1007/s00198-024-07241-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00198-024-07241-y','39264438', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00198-024-07241-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169341);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/osin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1007/s00198-024-07241-y" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Thyrotoxicosis leads to loss of bone mass. Vitamin D is important to bone health. In this randomized, placebo-controlled trial, we showed that bone restoration did not improve when adding vitamin D supplementation to standard care of Graves' disease thyrotoxicosis. Bone density and microarchitecture improved markedly with treatment of thyrotoxicosis. </div><div class="abstract-label">PURPOSE</div><div class="abstract-content">Vitamin D is important to skeletal health and ensuring a replete vitamin D status is recommended. In thyrotoxicosis, bone turnover is increased and bone mass density (BMD) reduced. We examined whether vitamin D supplementation improves bone recovery in thyrotoxicosis caused by Graves' disease (GD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">Using a double-blinded design, hyperthyroid patients with GD were randomized to vitamin D3 70 µg/day (2800 IU) or similar placebo as add-on to antithyroid drugs (ATD). At baseline and 9 months, we measured BMD and bone architecture using DXA and high resolution peripheral quantitative computerized tomography. Bone turnover markers (BTM) were measured at 3 months also. Effect of vitamin D versus placebo and the response to ATD treatment were analyzed using linear mixed modelling. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Eighty-six GD patients were included (age 41 ± 14 years, 86% females). Compared to placebo, vitamin D3 did not improve BMD or microarchitecture. In response to ATD, BMD increased in the hip by 2% (95%CI: 1-4%). Cortical porosity decreased in tibia (- 7% [95%CI: - 12 to - 2%]) and radius [- 14% [95%CI: - 24 to - 3%]), and trabecular thickness increased (tibia (5% [95%CI: 2 - 9%]) and radius (4% [95%CI: 1-7%]). Changes in BTM, but not thyroid hormones, were associated with changes in BMD by DXA and with changes in the cortical compartment. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In newly diagnosed GD, 9 months of high dose vitamin D3 supplementation does not offer benefit by improving skeletal health. Treatment of thyrotoxicosis is associated with the recovery of BMD and microarchitecture. </div><div class="abstract-label">CLINICALTRIAL</div><div class="abstract-label">GOV IDENTIFIER</div><div class="abstract-content">NCT02384668. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+microarchitecture%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone microarchitecture</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+turnover+markers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone turnover markers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Graves%e2%80%99+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Graves’ disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyrotoxicosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyrotoxicosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+D%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin D</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Graves+Disease%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Graves Disease/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Graves+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Graves Disease/drug therapy</a></li><li><a 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href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Aoyagi J</b>, Kanai T, Ito T, Saito T, Betsui H, Kurosaki M, Maru T, Ono M, Tajima T. Trends of bone mineral density and bone quality in a paediatric kidney transplant recipient: A case report. <em class='incite-journal-name' onclick='ShowInCiteJournal(17227);'>Nephrology (Carlton)</em> 2024;<b>29</b>:955-959. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39315463' target='_blank'>39315463</a> DOI: <a href='https://dx.doi.org/10.1111/nep.14382' target='_blank'>10.1111/nep.14382</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/nep.14382','39315463', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/nep.14382' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17227);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1111/nep.14382" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Kidney transplant (KT) requires long-term glucocorticoid (GC) treatment against acute and/or chronic rejection. Glucocorticoid-induced osteoporosis (GIOP) is one of the major concerns in kidney transplant recipients (KTRs). Therefore, it is essential to accumulate GIOP data from paediatric KTRs to aid in their healthy growth. A serial observational study of bone strength was carried out in an 8-year-old girl with bilateral hypoplastic kidney who underwent ABO-compatible living-donor KT and GC treatment over 2 years. Bone strength was evaluated by bone mineral density (BMD) and serum bone turnover markers (BTMs), including serum alkaline phosphatase (S-ALP), serum tartrate-resistant acid phosphatase 5b (S-TRACP-5b), and serum undercarboxylated osteocalcin (S-ucOC). All the levels of BTMs and BMD from 1 M to 4 M remained lower than the levels at 0 months (0 M: baseline). After gradual reduction of GC dose (4 M-24 M), S-ALP levels increased from baseline and S-TRACP-5b levels remained lower than the baseline level, but BMD recovered to baseline and increased. The S-ucOC levels did not increase from baseline. The patient's height growth velocity SDS was +3.99 for 23 months, and no fracture occurred during this observation period. A consistent, predominantly formative state of bone, which maintained higher S-ALP levels and lower S-TRACP-5b levels compared to baseline, could contribute to increased BMD. In addition, no increase in S-ucOC levels from baseline could be associated with no deterioration of bone strength. This case suggests that measurement of BMD and, S-ALP, TRACP-5b and ucOC could be useful for evaluating the trend on bone strength in a paediatric KTR. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+turnover+marker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone turnover marker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glucocorticoid%e2%80%90induced+osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glucocorticoid‐induced osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22kidney+transplant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">kidney transplant</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Transplantation%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Transplantation/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoids%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoids/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tartrate-Resistant+Acid+Phosphatase%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tartrate-Resistant Acid Phosphatase/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteocalcin%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteocalcin/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Absorptiometry%2c+Photon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Absorptiometry, Photon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Time+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Time Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunosuppressive+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunosuppressive Agents/adverse effects</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Mettwally WSA</b>, Hussein RA, Abdel Jaleel GA, Hassan A, Saleh DO, El-Beih AA. Cardenolides; calotropin and gomphogenin from Calotropis procera (Aiton) mitigate bone turnover in ovariectomized osteoporotic rats: Targeting RANKL/OPG axis and estrogen receptor-alpha. <em class='incite-journal-name' onclick='ShowInCiteJournal(9147);'>Fitoterapia</em> 2024;<b>179</b>:106226. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321857' target='_blank'>39321857</a> DOI: <a href='https://dx.doi.org/10.1016/j.fitote.2024.106226' target='_blank'>10.1016/j.fitote.2024.106226</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fitote.2024.106226','39321857', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fitote.2024.106226' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9147);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.fitote.2024.106226" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The present study aimed to examine the effect of Calotropis procera (Aiton) and its major cardenolides; calotropin and gomphogenin on ovariectomy-induced osteoporosis in rats. Osteoporotic rats were orally treated with C. procera alcoholic extract (100 mg/kg), calotropin (CLT; 100 μg/kg) and gomphogenin (GPG; 100 μg/kg) for 14 consecutive days. Bone resorption/formation biomarkers; bone specific alkaline phosphatase (BALP), osteoprotegerin (OPG) and nuclear factor-κβ ligand (RANKL) as well as serum calcium and phosphorus were assessed 24 h after last doses of treatments. Serum levels of estradiol (E2) and catalase were also measured. Oral treatment with C. procera extract, CLT and GPG caused E2 restoration to normal level with a marked regulation in the RANKL/OPG axis. Serum phosphorus and calcium were up-leveled whereas BALP was downregulated. Histopathological examination, bone histomorphometric analysis and immunohistochemical staining for osteopontin (OPN) inspection further emphasized the aforementioned outcomes. The results revealed the superiority of CLT and to a lesser extent GPG osteoporotic effect over C. procera extract. Molecular docking of the two compounds on ER-α and RANKL/OPG complex showed noteworthy binding affinities which also confirmed the supremacy of CLT due to the additional hydrogen bonding of the hydroxyl groups of the sugar moiety with RANKL/OPG complex. Finally, it is concluded that CLT and GPG from C. procera hinder bone turnover by decreasing osteoclastic bone cells activity and increasing calcium mineralization thus suppressing bone remodeling and preventing bone infirmity in OVX osteoporotic rats directly via binding to RANKL/OPG complex and ER-α and indirectly through elevating level of E2. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropis+procera%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropis procera</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ER-%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ER-α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gomphogenin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gomphogenin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANKL%2fOPG+complex%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANKL/OPG complex</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropis%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropis/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoprotegerin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoprotegerin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+Receptor+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen Receptor alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardenolides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardenolides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardenolides%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardenolides/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium/metabolism</a></li><li><a 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Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzoates%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzoates</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bridged+Bicyclo+Compounds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bridged Bicyclo Compounds</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sesquiterpenes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sesquiterpenes</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Yizhong B</b>, Chen F, Jin W, Dai J, Mao G, Song B. Sulfated galactofucan from Sargassum fusiforme protects against postmenopausal osteoporosis by regulating bone remodeling. <em class='incite-journal-name' onclick='ShowInCiteJournal(6800);'>Commun Biol</em> 2024;<b>7</b>:1471. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39516319' target='_blank'>39516319</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549216' target='_blank'>PMC11549216</a> DOI: <a href='https://dx.doi.org/10.1038/s42003-024-07097-2' target='_blank'>10.1038/s42003-024-07097-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s42003-024-07097-2','39516319', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s42003-024-07097-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/8110c462a6f1e907d388fe2f6f7b7879/42003_2024_Article_7097.PMC11549216.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s42003-024-07097-2');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6800);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1038/s42003-024-07097-2" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoporosis is a degenerative bone disease highly prevalent in older women, causing high morbidity and mortality rates. Fourteen kinds of fucoidan were isolated from Sargassum fusiforme through acid (named as SFS), alkaline (SFJ) and water (SFW). SFW was passed through an anion exchange column to obtain SFW-0, SFW-0.5 and SFW-2. SFW-0.5 and SFW-2 were degraded to obtain different sulfate group contents SFW-x-M/S/O (x for 0.5 or 2). We further confirmed SFW-0.5-O was the most effective fraction of SFW. SFW-0.5-O may have alternating backbones of (Gal)n and (Fuc)n, and the main sulfation may be at C2/C3 of the Fuc/Gal residues. SFW-0.5-O inhibition of OC differentiation was associated with IRF-8 signaling; meanwhile, SFW-0.5-O promoted osteoblast differentiation and bone mineral nodule formation. SFW-0.5-O also effectively ameliorated osteoporosis symptom caused by estrogen deprivation in vivo. We uncovered that the fucoidan active fraction SFW-0.5-O demonstrated effective bone protection, may be exploited for osteoporosis therapy. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polysaccharides</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sargassum%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sargassum/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sulfates%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sulfates/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edible+Seaweeds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edible Seaweeds</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China+(National+Science+Foundation+of+China)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">81801397 National Natural Science Foundation of China (National Science Foundation of China)</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Zou Y</b>, Wang Z, Shi H, Hu J, Hu W. Soybean Isoflavones Alleviate Osteoarthritis Through Modulation of the TSC1/mTORC1 Signaling Pathway to Reduce Intrachondral Angiogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(10916);'>Immunol Invest</em> 2024;<b>53</b>:1439-1455. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39360672' target='_blank'>39360672</a> DOI: <a href='https://dx.doi.org/10.1080/08820139.2024.2410737' target='_blank'>10.1080/08820139.2024.2410737</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/08820139.2024.2410737','39360672', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/08820139.2024.2410737' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10916);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1080/08820139.2024.2410737" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The incidence of osteoarthritis (OA) is increasing, yet its pathogenesis remains largely unknown. Recent studies suggest that abnormal subchondral bone remodeling plays a crucial role in OA development, highlighting a gap in clinical treatments targeting this aspect. Soybean Isoflavone (SI) has shown potential in treating OA, although its mechanisms are not fully understood. </div><div class="abstract-label">METHODS</div><div class="abstract-content">This research investigated the effects of SI on subchondral bone remodeling in an OA rat model, assessing joint damage, OARSI scores, and type H vessel formation (CD31hiEmcnhi expression). Additionally, the expression of ALP, OCN, BMP, and TSC1 was evaluated to determine involvement of the mTORC1 pathway. In vitro studies on IL-1β-induced osteoblasts further examined the impact of SI on TSC1/mTORC1 signaling and related markers. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">SI treatment reduced joint damage and OARSI scores in the rat OA model, significantly decreasing CD31hiEmcnhi expression, indicating a reduction in type H vessel formation. SI also downregulated ALP, OCN, and BMP expression while upregulating TSC1, suggesting inhibition of the mTORC1 signaling pathway and VEGF release. In vitro, SI increased TSC1 expression and decreased mTORC1 signaling, VEGF, ALP, OCN, and BMP levels in IL-1β-induced osteoblasts. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">SI targets the TSC1/mTORC1 signaling pathway to suppress osteoblast activation and VEGF release, inhibiting type H vessel formation and slowing abnormal subchondral bone remodeling. These findings provide a novel therapeutic approach for OA by focusing on subchondral bone remodeling mechanisms. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TSC1%2fmTORC1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TSC1/mTORC1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoblasts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoblasts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22soybean+isoflavones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">soybean isoflavones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22type+H+vessels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">type H vessels</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis+Complex+1+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis Complex 1 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberous+Sclerosis+Complex+1+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberous Sclerosis Complex 1 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mechanistic+Target+of+Rapamycin+Complex+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mechanistic Target of Rapamycin Complex 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycine+max%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycine max/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Pathologic%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Pathologic/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Tienforti D</b>, Marinelli L, Vervalcke J, Spagnolo L, Antolini F, Bichiri A, Baroni MG, Motta G, T'Sjoen G, Barbonetti A. Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4346);'>Calcif Tissue Int</em> 2024;<b>115</b>:624-635. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39356296' target='_blank'>39356296</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531450' target='_blank'>PMC11531450</a> DOI: <a href='https://dx.doi.org/10.1007/s00223-024-01296-z' target='_blank'>10.1007/s00223-024-01296-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00223-024-01296-z','39356296', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00223-024-01296-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4346);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ctin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s00223-024-01296-z" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Transgender and gender diverse individuals experience a gender identity that differs from the sex assigned at birth. Some transgender men may request testosterone to induce virilization; however, its impact on bone health remains to be fully elucidated. The objective of this systematic review and meta-analysis was to evaluate the modifications in bone metabolism over a short-term period among transgender men initiating testosterone therapy. A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library. The articles of interest had to report longitudinal evaluation conducted among transgender men, before starting testosterone and after 12 and 24 months of therapy. The analyzed parameters were BMD, calcium, phosphate, 25OHD, PTH, P1NP, BAP, osteocalcin and CTx. Mean differences with 95% coefficient intervals were combined using random effects models. Funnel plot, Egger's test, and trim-and-fill analysis were used to assess publication bias. Fourteen studies met the inclusion criteria, including 1484 subjects. In absence of heterogeneity, BMD did not significantly change at lumbar spine, hip, femoral neck, and whole-body evaluations. Calcium, phosphate, 25OHD and PTH remained stable over time. Regarding bone turnover markers, only P1NP showed a statistically significant increase after 12 months of T therapy, in absence of heterogeneity (SMD 0.61 mcg/l; 95% CI: 0.40-0.83; p < 0.0001; I2 = 0%, Pforheterogeneity = 0.48). Testosterone therapy among transgender men seems not to disrupt bone health after 12 and 24 months. A statistically significant elevation in P1NP levels after 12 months of therapy may indicate a positive anabolic effect of testosterone in the short-term. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+turnover+markers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone turnover markers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GAHT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GAHT</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gender+incongruence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gender incongruence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testosterone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testosterone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transmen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transmen</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transgender+Persons%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transgender Persons</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testosterone%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testosterone/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Universit%c3%a0+degli+Studi+dell%e2%80%99Aquila%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Università degli Studi dell’Aquila</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Wang F</b>, Wei W, Liu PJ. Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9342);'>Front Endocrinol (Lausanne)</em> 2024;<b>15</b>:1487998. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39553313' target='_blank'>39553313</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563942' target='_blank'>PMC11563942</a> DOI: <a href='https://dx.doi.org/10.3389/fendo.2024.1487998' target='_blank'>10.3389/fendo.2024.1487998</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fendo.2024.1487998','39553313', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fendo.2024.1487998' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fendo.2024.1487998');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9342);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.frontiersin.org/people/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.3389/fendo.2024.1487998" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Context</div><div class="abstract-content">The beneficial effects of probiotic supplementation on bone health in postmenopausal women require further validation. </div><div class="abstract-label">Objective</div><div class="abstract-content">This study systematically reviewed and conducted a meta-analysis of randomized controlled trials (RCTs) to assess the relationship between probiotic supplementation and changes in bone mineral density (BMD) and bone turnover markers (BTMs) among postmenopausal women. </div><div class="abstract-label">Methods</div><div class="abstract-content">A systematic search was conducted across four databases to retrieve data on lumbar spine BMD, hip BMD, collagen type 1 cross-linked C-telopeptide (CTX), receptor activator of nuclear factor-κB ligand (RANKL), osteocalcin (OC), osteoprotegerin (OPG), N-terminal propeptide of type 1 procollagen (P1NP), and bone-specific alkaline phosphatase (BALP) in postmenopausal women. Eligible RCTs were quantitatively analyzed using random-effects meta-analyses. Additional analyses, including subgroup, sensitivity, and meta-regression analyses, were performed. </div><div class="abstract-label">Results</div><div class="abstract-content">Twelve RCTs involving 1183 postmenopausal women were included. Compared with the control group, postmenopausal women who received probiotic supplementation showed significantly greater BMD in both the lumbar spine (standardized mean difference [SMD] = 0.60, 95% confidence interval [CI] 0.14 to 1.05) and the hip (SMD = 0.74, 95%CI 0.15 to 1.33). Additionally, probiotic supplementation was associated with reduced levels of CTX (SMD = -1.51, 95%CI -1.88 to -0.41) and BALP (SMD = -1.80, 95%CI -2.78 to -0.81). No significant differences were found between the probiotic and control groups in terms of other BTMs. Subgroup analyses revealed that the increase in BMD due to probiotic supplementation was more significant in postmenopausal women with osteopenia than in those with osteoporosis. The meta-analysis results for both lumbar spine and hip BMD remained robust after conducting sensitivity analyses and meta-regressions. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Supplementation with probiotics may increase BMD among postmenopausal women, with stronger evidence in women with osteopenia than osteoporosis. Further RCTs are suggested to confirm and refine these findings. </div><div class="abstract-label">Systematic review registration</div><div class="abstract-content">https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024576764. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+turnover+marker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone turnover marker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteopenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteopenia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22postmenopausal+women%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">postmenopausal women</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22probiotic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">probiotic</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Probiotics%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Probiotics/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Probiotics%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Probiotics/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postmenopause%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postmenopause</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dietary+Supplements%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dietary Supplements</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Randomized+Controlled+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Randomized Controlled Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Zhu H</b>, Shen F, Liao T, Qian H, Liu Y. Sporidiobolus pararoseus polysaccharides relieve rheumatoid arthritis by regulating arachidonic acid metabolism and bone remodeling signaling pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2024;<b>281</b>:136272. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366615' target='_blank'>39366615</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.136272' target='_blank'>10.1016/j.ijbiomac.2024.136272</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.136272','39366615', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijbiomac.2024.136272' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.ijbiomac.2024.136272" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rheumatoid arthritis (RA) is an autoimmune-mediated disease with the highest disability rate. Sporidiobolus pararoseus polysaccharides (SPP) have been demonstrated to have anti-rheumatoid and microbiota-modulatory effects; however, the underlying mechanisms remain unclear. This study employed collagen-induced arthritis (CIA) mice to explore the metabolic and genetic pathways. The results revealed SPP intervention significantly reduced the serum levels of rheumatoid and pro-inflammatory complement factors. SPP promoted the transition of macrophages of CIA mice toward the M2 phenotype (F4/80+/CD206+) from an inflammatory phenotype (F4/80+/CD86+) using flow cytometry analysis. A total of 44 metabolites were upregulated, and 110 metabolites were significantly downregulated by SPP compared to those in RA group. The decreased metabolites, 12(S)-HPETE, prostaglandin H2, 15-HETE, hepoxilin B3, and 15-keto-prostaglandin F2a, were mostly enriched in arachidonic acid metabolism (enrichment = 11.4 %), which was highly correlated with the anti-rheumatic activity of SPP. Gene expression analysis revealed that SPP significantly regulated OPG/RANKL/TRAF6 signaling pathway, stimulating osteogenic remodeling. Furthermore, arachidonic acid metabolism was identified as the critical metabolic driver of RA phenotypes and osteoclast differentiation, potentially associated with SPP-reshaped intestinal microbiota (i.e., Rikenellaceae_RC9_gut_group, Bacteroides, and Parabacteroides). Collectively, this study utilized an integrated approach of metabolomics and gene expression analysis to investigate the regulatory role of SPP in RA progression. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arachidonic+acid+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arachidonic acid metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basidiomycota%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basidiomycota/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arachidonic+Acid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arachidonic Acid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fungal+Polysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fungal Polysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fungal+Polysaccharides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fungal Polysaccharides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Liang E</b>, Beshara M, Sheng H, Huang XW, Roh JM, Laurent CA, Lee C, Delmerico J, Tang L, Lo JC, Hong CC, Ambrosone CB, Kushi LH, Kwan ML, Yao S. A prospective study of vitamin D, proinflammatory cytokines, and risk of fragility fractures in women on aromatase inhibitors for breast cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(4269);'>Breast Cancer Res Treat</em> 2024;<b>208</b>:349-358. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38976164' target='_blank'>38976164</a> DOI: <a href='https://dx.doi.org/10.1007/s10549-024-07423-6' target='_blank'>10.1007/s10549-024-07423-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10549-024-07423-6','38976164', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s10549-024-07423-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4269);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1007/s10549-024-07423-6" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Vitamin D is critical to bone health by regulating intestinal absorption of calcium, whereas proinflammatory cytokines, including IL-1, IL-6, IL-12, and TNF-α, are known to increase bone resorption. We hypothesized that vitamin D and these cytokines at the time of breast cancer diagnosis were predictive for fragility fractures in women receiving aromatase inhibitors (AIs). </div><div class="abstract-label">METHODS</div><div class="abstract-content">In a prospective cohort of 1,709 breast cancer patients treated with AIs, we measured the levels of 25-hydroxyvitamin D (25OHD), IL-1β, IL-6, IL-12, and TNF-α from baseline blood samples. The associations of these biomarkers were analyzed with bone turnover markers (BALP and TRACP), bone regulatory markers (OPG and RANKL), bone mineral density (BMD) close to cancer diagnosis, and risk of fragility fractures during a median of 7.5 years of follow up. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Compared to patients with vitamin D deficiency, patients with sufficient levels had higher bone turnover, lower BMD, and higher fracture risk; the latter became non-significant after controlling for covariates including BMD and no longer existed when patients taking vitamin D supplement or bisphosphonates or with history of fracture or osteoporosis were excluded. There was a non-significant trend of higher levels of IL-1β and TNF-α associated with higher risk of fracture (highest vs. lowest tertile, IL-1β: adjusted HR=1.37, 95% CI=0.94-1.99; TNF-α: adjusted HR=1.38, 95% CI=0.96-1.98). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our results do not support proinflammatory cytokines or vitamin D levels as predictors for risk of fragility fractures in women receiving AIs for breast cancer. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aromatase+inhibitor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aromatase inhibitor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fracture%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fracture</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+study%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective study</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+D%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin D</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aromatase+Inhibitors%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aromatase Inhibitors/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aromatase+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aromatase Inhibitors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+D%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin D/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+D%2fanalogs+%26amp%3b+derivatives%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin D/analogs & derivatives</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fractures%2c+Bone%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fractures, Bone/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fractures%2c+Bone%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fractures, Bone/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risk+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risk Factors</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA166701 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Qu Z</b>, Zhao S, Zhang Y, Wang X, Yan L. Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways. <em class='incite-journal-name' onclick='ShowInCiteJournal(3668);'>Biomed Pharmacother</em> 2024;<b>180</b>:117490. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39332184' target='_blank'>39332184</a> DOI: <a href='https://dx.doi.org/10.1016/j.biopha.2024.117490' target='_blank'>10.1016/j.biopha.2024.117490</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biopha.2024.117490','39332184', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biopha.2024.117490' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3668);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.biopha.2024.117490" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In the process of bone metabolism and bone remodeling, bone marrow mesenchymal stem cells (BM-MSCs) differentiate into osteoblasts (OBs) under certain conditions to enable the formation of new bone, and normal bone reconstruction and pathological bone alteration are closely related to the differentiation and proliferation functions of OBs. Osteogenic differentiation of BM-MSCs involves multiple signaling pathways, which function individually but interconnect intricately to form a complex signaling regulatory network. Natural compounds have fewer adverse effects than chemically synthesized drugs, optimize bone health, and are more suitable for long-term use. In this paper, we focus on OBs, summarize the current research progress of signaling pathways related to OBs differentiation, and review the molecular mechanisms by which chemically synthesized drugs with potential anti-osteoporosis properties regulate OBs-mediated bone formation. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+remodeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone remodeling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+compounds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural compounds</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblast+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblast differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signaling+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signaling pathways</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biological+Products%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biological Products/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Suwan A</b>, Tanavalee C, Panyakhamlerd K, Ngarmukos S, Chavaengkiat S, Tanavalee A, Amarase C, Bumphenkiatikul T. Changes of bone turnover markers and bone mineral density among postmenopausal Thai women with osteoporosis receiving generic risedronate. <em class='incite-journal-name' onclick='ShowInCiteJournal(168699);'>BMC Womens Health</em> 2024;<b>24</b>:572. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39462376' target='_blank'>39462376</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515129' target='_blank'>PMC11515129</a> DOI: <a href='https://dx.doi.org/10.1186/s12905-024-03404-5' target='_blank'>10.1186/s12905-024-03404-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12905-024-03404-5','39462376', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12905-024-03404-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168699);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1186/s12905-024-03404-5" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Osteoporosis has been recognized as a significant health issue in Thailand. Pharmacological interventions are important way to prevent fracture. However, one of the main challenges in selecting a medication is high cost, particularly for brand-name drugs. Data on generic bisphosphonate use in Thai are still lacking. Therefore, our study aimed to assess the efficacy and safety of generic risedronate in postmenopausal Thai women with osteoporosis. </div><div class="abstract-label">METHODS</div><div class="abstract-content">This prospective study was conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, from December 2022 to January 2024. Serum C-terminal cross-linking telopeptide of type I collagen (CTX) and procollagen type I N-propeptide (P1NP) were measured at baseline. All participants subsequently received 35 milligrams of oral risedronate once weekly for 52 weeks. Serum CTX and P1NP were remeasured at different time points. BMD was reevaluated at 52 weeks after risedronate treatment initiation. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">A total of 80 participants were included. The mean age was 65.2 ± 6.6 years. The mean body mass index (BMI) was 23.45 ± 3.49 kg/m2. The median (IQR) serum CTX level at 12 weeks was significantly lower than that at baseline (0.28 (0.16-0.46) ng/mL versus 0.44 (0.26-0.64) ng/mL, respectively; p value < 0.01). The suppression of serum CTX was confirmed at 52 weeks after treatment initiation. Compared with those at baseline, the serum P1NP levels were significantly lower at 24 weeks after treatment initiation (30.33 (19.19-39.58) ng/mL versus 41.90 (30.33-68.67) ng/mL, respectively; p value < 0.01). In terms of the BMD assessment at 52 weeks, significant improvements were observed in both areal BMD (g/cm2) and T scores at all measured sites compared with baseline. The lumbar spine, femoral neck, and total hip BMD increased from baseline by 4.76%, 3.84% and 4.54%, respectively. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Postmenopausal women with osteoporosis who were treated with generic risedronate demonstrated significant suppression of the bone remodelling process at 3, 6, and 12 months after treatment initiation. Additionally, significant improvements in the lumbar spine, femoral neck, and total hip BMD were observed at 12 months of therapy. These findings suggest that generic risedronate could be considered a reasonable and interesting option for treating postmenopausal women with osteoporosis in Thailand. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+turnover+markers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone turnover markers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postmenopausal+women%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postmenopausal women</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risedronate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risedronate</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risedronic+Acid%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risedronic Acid/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thailand%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thailand</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Generic%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Generic/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen+Type+I%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen Type I/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Procollagen%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Procollagen/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptide+Fragments%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptide Fragments/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Southeast+Asian+People%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Southeast Asian People</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Wu Y</b>, Wu Z, Li Z, Hong Y. Simulation of the bone remodelling microenvironment by calcium compound-loaded hydrogel fibrous membranes for <i>in situ</i> bone regeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(14511);'>J Mater Chem B</em> 2024;<b>12</b>:10012-10027. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39248119' target='_blank'>39248119</a> DOI: <a href='https://dx.doi.org/10.1039/d4tb01088d' target='_blank'>10.1039/d4tb01088d</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1039/d4tb01088d','39248119', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1039/d4tb01088d' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14511);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1039/d4tb01088d" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The endowment of guided bone regeneration (GBR) membranes with the ability to activate the endogenous regenerative capability of bone to regenerate bone defects is of clinical significance. Herein we explored the preparation of the calcium compound (CC) (calcium sulfate (CaSL), calcium hydrophosphate (CaHP), or tricalcium phosphate (TCaP)) loaded ultrathin silk fibroin (SF)/gelatin (G) fibre membranes via electrospinning as the GBR membranes to regenerate the calvarial bone defects. The in vitro experiments demonstrated that the CaSL-loaded ultrathin fibrous membranes could simulate optimally the bone remodelling microenvironment in comparison with the CaHP- and TCaP-loaded fibrous membranes, displaying the highest activity to regulate the migration, proliferation, and differentiation of mesenchymal stem cells (MSCs). Also, the in vivo experiments demonstrated that the CaSL-loaded fibrous membranes presented the highest intrinsic osteoinduction to guide in situ regeneration of bone. Furthermore, the in vivo experiments demonstrated that the as-prepared composite fibrous membranes possessed good degradability. In summary, our results suggested that the CaSL-loaded fibrous membranes with high intrinsic osteoinduction and good degradability have potential to translate into clinical practice. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium Compounds/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biocompatible+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biocompatible Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biocompatible+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biocompatible Materials/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Shariff JRR</b>, Swe KM, Binkley N, Whyte MP, Pabich SK. Skeletal fluorosis: an uncommon cause, yet a rescue treatment? <em class='incite-journal-name' onclick='ShowInCiteJournal(169341);'>Osteoporos Int</em> 2024;<b>35</b>:1859-1863. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38847810' target='_blank'>38847810</a> DOI: <a href='https://dx.doi.org/10.1007/s00198-024-07137-x' target='_blank'>10.1007/s00198-024-07137-x</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00198-024-07137-x','38847810', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00198-024-07137-x' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169341);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/osin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1007/s00198-024-07137-x" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Skeletal fluorosis (SF) results from chronic exposure to fluoride (F-) causing excessive aberrantly mineralized brittle bone tissue, fractures, and exostoses. There is no established treatment other than avoiding the source of F-. Still, excess F- can persist in bone for decades after exposure ceases. </div><div class="abstract-label">CASE PRESENTATION</div><div class="abstract-content">A 50-year-old woman presented with multiple, recurrent, low AQ2 trauma fractures yet high radiologic bone mineral density. Serum F- was elevated, and osteomalacia was documented by non-decalcified transiliac biopsy. She reported intermittently "huffing" a keyboard cleaner containing F- (difluoroethane) for years. Following cessation of her F- exposure, we evaluated the administration of the parathyroid hormone analog, abaloparatide, hoping to increase bone remodeling and diminish her skeletal F- burden. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Due to the prolonged half-life of F- in bone, SF can cause fracturing long after F- exposure stops. Anabolic therapy approved for osteoporosis, such as abaloparatide, may induce mineralized bone turnover to replace the poorly mineralized osteomalacic bone characteristic of SF and thereby diminish fracture risk. Following abaloparatide treatment for our patient, there was a decrease in bone density as well as a reduction in F- levels. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Abaloparatide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Abaloparatide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluoride%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluoride</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluorocarbon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluorocarbon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fractures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fractures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteomalacia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteomalacia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skeletal+fluorosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skeletal fluorosis</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteomalacia%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteomalacia/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parathyroid+Hormone-Related+Protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parathyroid Hormone-Related Protein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporotic+Fractures%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporotic Fractures/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporotic+Fractures%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporotic Fractures/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporotic+Fractures%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporotic Fractures/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fractures%2c+Multiple%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fractures, Multiple/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluorides%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluorides/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluorides%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluorides/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluoride+Poisoning%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluoride Poisoning/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Diseases%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Diseases/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/adverse effects</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Jin J</b>, Yue L, Lu Y, Zhen Z, Wu H, Shan X. Changes in serum bone turnover markers and bone mineral density Z-score in children with osteogenesis imperfecta after zoledronic acid treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(169108);'>J Investig Med</em> 2024;<b>72</b>:715-722. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38715223' target='_blank'>38715223</a> DOI: <a href='https://dx.doi.org/10.1177/10815589241254047' target='_blank'>10.1177/10815589241254047</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/10815589241254047','38715223', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/10815589241254047' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169108);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1177/10815589241254047" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The study aimed to investigate the changes in the levels of serum bone turnover markers (BTMs) and bone mineral density (BMD) Z-score in pediatric patients with osteogenesis imperfecta (OI) after intravenous bisphosphonate therapy and their association with age and estimated glomerular filtration rate (eGFR). This retrospective study analyzed data from 10 pediatric OI patients treated with intravenous zoledronic acid for over 1 year. Patients' clinical data were collected. The levels of BTMs and BMD Z-score before and after zoledronic acid treatment were analyzed. Significant improvement in BMD Z-score was observed after 6 and 12 months of treatment compared to baseline (all p < 0.05). The N-terminal propeptide of type I procollagen (PINP) levels decreased over time (all p < 0.05), indicating that zoledronic acid treatment decreased bone turnover. The levels of beta-C-terminal telopeptide of type I collagen remained stable after treatment. No correlation was found between PINP level and age, eGFR, or BMD (all p > 0.05). Bisphosphonate treatment can improve BMD and decrease bone turnover (indicated by decreased levels of PINP) in pediatric OI patients. PINP may serve as an independent indicator for monitoring the efficacy of bisphosphonate treatment in pediatric OI patients, particularly in those under the age of 6, where standardized BMD Z-score criteria are lacking. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis+imperfecta%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis imperfecta</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PINP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PINP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+mineral+density+Z-score%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone mineral density Z-score</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22children%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">children</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22serum+bone+turnover+markers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">serum bone turnover markers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22zoledronic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">zoledronic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b2-CTX%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">β-CTX</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zoledronic+Acid%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zoledronic Acid/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis+Imperfecta%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis Imperfecta/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis+Imperfecta%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis Imperfecta/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diphosphonates%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diphosphonates/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Imidazoles%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Imidazoles/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptide+Fragments%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptide Fragments/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Procollagen%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Procollagen/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Harrison K</b>, Loundagin L, Hiebert B, Panahifar A, Zhu N, Marchiori D, Arnason T, Swekla K, Pivonka P, Cooper D. Glucocorticoids disrupt longitudinal advance of cortical bone basic multicellular units in the rabbit distal tibia. <em class='incite-journal-name' onclick='ShowInCiteJournal(4121);'>Bone</em> 2024;<b>187</b>:117171. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38901788' target='_blank'>38901788</a> DOI: <a href='https://dx.doi.org/10.1016/j.bone.2024.117171' target='_blank'>10.1016/j.bone.2024.117171</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bone.2024.117171','38901788', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bone.2024.117171' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4121);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/bone/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.bone.2024.117171" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Glucocorticoids (GCs) are the leading cause of secondary osteoporosis. The emerging perspective, derived primarily from 2D histological study of trabecular bone, is that GC-induced bone loss arises through the uncoupling of bone formation and resorption at the level of the basic multicellular unit (BMU), which carries out bone remodeling. Here we explore the impact of GCs on cortical bone remodeling in the rabbit model. Based upon the rapid reduction of bone formation and initial elevation of resorption caused by GCs, we hypothesized that the rate of advance (longitudinal erosion rate; LER) of cortical BMUs would be increased. To test this hypothesis we divided 20 female New Zealand White rabbits into four experimental groups: ovariohysterectomy (OVH), glucocorticoid (GC), OVH + GC and SHAM controls (n = 5 animals each). Ten weeks post-surgery (OVH or sham), and two weeks after the initiation of dosing (daily subcutaneous injections of 1.5 mg/kg of methylprednisolone sodium succinate in the GC-treated groups and 1 ml of saline for the others), the right tibiae were scanned in vivo using Synchrotron Radiation (SR) in-line phase contrast micro-CT at the Canadian Light Source. After an additional 2 weeks of dosing, the rabbits were euthanized and ex vivo images were collected using desktop micro-CT. The datasets were co-registered in 3D and LER was calculated as the distance traversed by BMU cutting-cones in the 14-day interval between scans. Counter to our hypothesis, LER was greatly reduced in GC-treated rabbits. Mean LER was lower in GC (4.27 μm/d; p < 0.001) and OVH + GC (4.19 μm/d; p < 0.001), while similar in OVH (40.13 μm/d; p = 0.990), compared to SHAM (40.44 μm/d). This approximately 90 % reduction in LER with GCs was also associated with an overall disruption of BMU progression, with radial expansion of the remodeling space occurring in all directions. This unexpected outcome suggests that GCs do not simply uncouple formation and resorption within cortical BMUs and highlights the value of the time-lapsed 4D approach employed. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+multicellular+unit%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic multicellular unit</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cortical+bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cortical bone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoid-induced+osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoid-induced osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rabbit%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rabbit</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synchrotron%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synchrotron</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rabbits%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rabbits</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibia%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibia/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cortical+Bone%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cortical Bone/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cortical+Bone%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cortical Bone/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22X-Ray+Microtomography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">X-Ray Microtomography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Guisado-Cuadrado I</b>, Romero-Parra N, Elliott-Sale KJ, Sale C, Díaz ÁE, Peinado AB. Influence of Menstrual Cycle and Oral Contraceptive Phases on Bone (re)modelling Markers in Response to Interval Running. <em class='incite-journal-name' onclick='ShowInCiteJournal(4346);'>Calcif Tissue Int</em> 2024;<b>115</b>:382-392. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39066926' target='_blank'>39066926</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405431' target='_blank'>PMC11405431</a> DOI: <a href='https://dx.doi.org/10.1007/s00223-024-01259-4' target='_blank'>10.1007/s00223-024-01259-4</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00223-024-01259-4','39066926', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00223-024-01259-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4346);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ctin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1007/s00223-024-01259-4" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">To explore how sex hormone fluctuations may affect bone metabolism, this study aimed to examine P1NP and β-CTX-1 concentrations across the menstrual and oral contraceptive (OC) cycle phases in response to running. 17β-oestradiol, progesterone, P1NP and β-CTX-1 were analysed pre- and post-exercise in eight eumenorrheic females in the early-follicular, late-follicular, and mid-luteal phases, while 8 OC users were evaluated during the withdrawal and active pill-taking phases. The running protocol consisted of 8 × 3min treadmill runs at 85% of maximal aerobic speed. 17β-oestradiol concentrations (pg·ml-1) were lower in early-follicular (47.22 ± 39.75) compared to late-follicular (304.95 ± 235.85;p = < 0.001) and mid-luteal phase (165.56 ± 80.6;p = 0.003) and higher in withdrawal (46.51 ± 44.09) compared to active pill-taking phase (10.88 ± 11.24;p < 0.001). Progesterone (ng·ml-1) was higher in mid-luteal (13.214 ± 4.926) compared to early-follicular (0.521 ± 0.365; p < 0.001) and late-follicular phase (1.677 ± 2.586;p < 0.001). In eumenorrheic females, P1NP concentrations (ng·ml-1) were higher in late-follicular (69.97 ± 17.84) compared to early-follicular (60.96 ± 16.64;p = 0.006;) and mid-luteal phase (59.122 ± 11.77;p = 0.002). β-CTX-1 concentrations (ng·ml-1) were lower in mid-luteal (0.376 ± 0.098) compared to late-follicular (0.496 ± 0.166; p = 0.001) and early-follicular phase (0.452 ± 0.148; p = 0.039). OC users showed higher post-exercise P1NP concentrations in withdrawal phase (61.75 ± 8.32) compared to post-exercise in active pill-taking phase (45.45 ± 6;p < 0.001). Comparing hormonal profiles, post-exercise P1NP concentrations were higher in early-follicular (66.91 ± 16.26;p < 0.001), late-follicular (80.66 ± 16.35;p < 0.001) and mid-luteal phases (64.57 ± 9.68;p = 0.002) to active pill-taking phase. These findings underscore the importance of studying exercising females with different ovarian hormone profiles, as changes in sex hormone concentrations affect bone metabolism in response to running, showing a higher post-exercise P1NP concentrations in all menstrual cycle phases compared with active pill-taking phase of the OC cycle. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endurance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endurance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eumenorrheic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eumenorrheic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oestradiol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oestradiol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22P1NP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P1NP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b2CTX-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">βCTX-1</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menstrual+Cycle%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menstrual Cycle/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Running%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Running/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Contraceptives%2c+Oral%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Contraceptives, Oral/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Progesterone%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Progesterone/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministerio+de+Econom%c3%ada+y+Competitividad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DEP2016-75387-P Ministerio de Economía y Competitividad</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Universidad+Polit%c3%a9cnica+de+Madrid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Universidad Politécnica de Madrid</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Quek YY</b>, Cheng LJ, Ng YX, Hey HWD, Wu XV. Effectiveness of anthocyanin-rich foods on bone remodeling biomarkers of middle-aged and older adults at risk of osteoporosis: a systematic review, meta-analysis, and meta-regression. <em class='incite-journal-name' onclick='ShowInCiteJournal(18342);'>Nutr Rev</em> 2024;<b>82</b>:1187-1207. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37796900' target='_blank'>37796900</a> DOI: <a href='https://dx.doi.org/10.1093/nutrit/nuad121' target='_blank'>10.1093/nutrit/nuad121</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/nutrit/nuad121','37796900', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/nutrit/nuad121' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18342);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1093/nutrit/nuad121" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">CONTEXT</div><div class="abstract-content">Current osteoporosis pharmacological treatment has undesirable side effects. There is increasing focus on naturally derived food substances that contain phytonutrients with antioxidant effects in promoting health and regulating immune response. </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">This review aims to systematically evaluate the effectiveness of anthocyanin-rich foods on bone remodeling biomarkers in middle-aged and older adults (≥40 y old) at risk of osteoporosis. </div><div class="abstract-label">DATA SOURCES</div><div class="abstract-content">Randomized controlled trials were searched on 8 bibliographic databases of PubMed, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Food Science and Technology Abstracts, Cochrane Library, and ProQuest. </div><div class="abstract-label">DATA EXTRACTION AND ANALYSIS</div><div class="abstract-content">Thirteen studies were included in the meta-analysis. Receptor activator of nuclear factor kappa-B ligand (RANKL) is exhibited from osteoblastic cells that gathered osteoclasts to bone sites for bone resorption, accelerating bone loss. Anthocyanin-rich food consumption showed statistically nonsignificant effects, with no substantial heterogeneity on bone remodeling biomarkers. However, there was a significant increase in lumbar spine L1-L4 bone mineral density. Mild-to-small effects were seen to largely favor the consumption of anthocyanin-rich foods. Berries (d = -0.44) have a larger effect size of RANKL than plums (d = 0.18), with statistically significant subgroup differences. Random-effects meta-regression found body mass index, total attrition rate, total energy, and dietary carbohydrate and fat intake were significant covariates for the effect size of RANKL. All outcomes had low certainty of evidence. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Anthocyanin-rich foods may improve bone health in middle-aged and older adults at risk of osteoporosis. This review contributes to the growing interest in nutrient-rich foods as a low-cost and modifiable alternative to promote human health and reduce disease burden. Future high-quality studies with larger sample sizes and longer treatment durations are required to fully understand the effect of anthocyanin-rich foods on bone health. </div><div class="abstract-label">SYSTEMATIC REVIEW REGISTRATION</div><div class="abstract-content">PROSPERO registration no. CRD42022367136. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anthocyanin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anthocyanin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+alkaline+phosphatase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone alkaline phosphatase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+remodeling+biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone remodeling biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22middle-aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">middle-aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22older+adults%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">older adults</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22postmenopausal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">postmenopausal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22receptor+activator+of+nuclear+factor+kappa-B+ligand%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">receptor activator of nuclear factor kappa-B ligand</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anthocyanins%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anthocyanins/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anthocyanins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anthocyanins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Randomized+Controlled+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Randomized Controlled Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fruit%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fruit/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Li N</b>, Jørgensen NR, Reginster JY, Hiligsmann M. The impact of bone turnover marker on medication adherence and the health economics-related consequences. <em class='incite-journal-name' onclick='ShowInCiteJournal(9081);'>Expert Rev Pharmacoecon Outcomes Res</em> 2024;<b>24</b>:787-790. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38568796' target='_blank'>38568796</a> DOI: <a href='https://dx.doi.org/10.1080/14737167.2024.2337718' target='_blank'>10.1080/14737167.2024.2337718</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/14737167.2024.2337718','38568796', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/14737167.2024.2337718' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9081);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1080/14737167.2024.2337718" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+turnover+makers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone turnover makers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22economic+impact%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">economic impact</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22medication+adherence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">medication adherence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22treatment+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">treatment response</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; 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Regional difference in the distribution of alkaline phosphatase, PHOSPHO1, and calcein labeling in the femoral metaphyseal trabeculae in parathyroid hormone-administered mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(167255);'>J Oral Biosci</em> 2024;<b>66</b>:554-566. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38942193' target='_blank'>38942193</a> DOI: <a href='https://dx.doi.org/10.1016/j.job.2024.06.007' target='_blank'>10.1016/j.job.2024.06.007</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.job.2024.06.007','38942193', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.job.2024.06.007' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(167255);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.job.2024.06.007" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVES</div><div class="abstract-content">This study aimed to elucidate whether the administration of parathyroid hormone (PTH) results in remodeling- or modeling-based bone formation in different regions of the murine femora, and whether the PTH-driven bone formation would facilitate osteoblastic differentiation into osteocytes. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Six-week-old male C57BL/6J mice were employed to examine the distribution of alkaline phosphatase (ALP), PHOSPHO1, podoplanin, and calcein labeling in two distinct long bone regions: the metaphyseal trabeculae close to the chondro-osseous junction (COJ) and those distant from the COJ in three mouse groups, a control group receiving a vehicle (sham group) and groups receiving hPTH (1-34) twice a day (PTH BID group) or four times a day (PTH QID group) for two weeks. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The sham group showed PHOSPHO1-reactive mature osteoblasts localized primarily at the COJ, whereas the PTH BID/QID groups exhibited extended lines of PHOSPHO1-reactive osteoblasts even in regions distant from the COJ. The PTH QID group displayed fragmented calcein labeling in trabeculae close to the COJ, whereas continuous labeling was observed in trabeculae distant from the COJ. Osteoblasts tended to express podoplanin and PHOSPHO1 independently in the close and distant regions of the sham group, while osteoblasts in the PTH-administered groups showed immunoreactivity of podoplanin and PHOSPHO1 together in the close and distant regions. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Administration of PTH may accelerate remodeling-based bone formation in regions close to the COJ while predominantly inducing modeling-based bone formation in distant regions. PTH appeared to simultaneously facilitate osteoblastic bone mineralization and differentiation into osteocytes in both remodeling- and modeling-based bone formation. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+phosphatase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline phosphatase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+tissue%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone tissue</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunohistochemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunohistochemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PHOSPHO1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PHOSPHO1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parathyroid+hormone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parathyroid hormone</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parathyroid+Hormone%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parathyroid Hormone/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parathyroid+Hormone%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parathyroid Hormone/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluoresceins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluoresceins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Glycoproteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Glycoproteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphoric+Monoester+Hydrolases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphoric Monoester Hydrolases</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Kim HJ</b>, Choi SA, Gu MS, Ko SY, Kwon JH, Han JY, Kim JH, Kim MG. Effects of Glucagon-Like Peptide-1 Receptor Agonist on Bone Mineral Density and Bone Turnover Markers: A Meta-Analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(168836);'>Diabetes Metab Res Rev</em> 2024;<b>40</b>:e3843. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39311048' target='_blank'>39311048</a> DOI: <a href='https://dx.doi.org/10.1002/dmrr.3843' target='_blank'>10.1002/dmrr.3843</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/dmrr.3843','39311048', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/dmrr.3843' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168836);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/dmrr' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1002/dmrr.3843" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">Glucagon-like peptide-1 receptor agonist (GLP-1RA) may promote bone formation, but conversely, they could also weaken bones due to the reduction in mechanical load associated with weight loss. However, the clinical effects in humans have not been clearly demonstrated. This meta-analysis aimed to evaluate whether GLP-1RAs affect BMD and bone turnover markers. </div><div class="abstract-label">MATERIAL AND METHODS</div><div class="abstract-content">PubMed, Embase, and Scopus were searched on June 13, 2024. The eligibility criteria were: (1) human studies, (2) receiving a GLP-1RA for more than 4 weeks, (3) an untreated control group or a placebo group, (4) reporting of at least one BMD or bone turnover marker, and (5) an RCT design. The risk of bias was assessed using the Cochrane risk of bias 2 tool. Fixed- or random-effects meta-analysis was performed according to heterogeneity. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Seven studies were included in the meta-analysis. GLP-1RAs did not significantly change BMD in the femoral neck (mean difference [MD], 0.01 g/cm2; 95% CI, -0.01-0.04 g/cm2), in the total hip (MD, -0.01 g/cm2; 95% CI, -0.02-0.01 g/cm2), and in the lumbar spine (MD, 0 g/cm2; 95% CI, -0.02-0.02 g/cm2). C-terminal telopeptide of type 1 collagen (CTX), a bone resorption marker, significantly increased after GLP-1RA treatment (MD, 0.04 μg/L; 95% CI, 0.01-0.07 μg/L). GLP-1RAs did not significantly change bone formation markers such as procollagen type 1 N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">GLP-1RA did not affect BMD and bone formation markers. However, GLP-1RAs led to a significant increase in CTX. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+formation+marker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone formation marker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+resorption+marker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone resorption marker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glucagon%e2%80%90like+peptide%e2%80%901+receptor+agonist%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glucagon‐like peptide‐1 receptor agonist</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22meta%e2%80%90analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">meta‐analysis</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucagon-Like+Peptide-1+Receptor+Agonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucagon-Like Peptide-1 Receptor Agonists/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucagon-Like+Peptide-1+Receptor+Agonists%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucagon-Like Peptide-1 Receptor Agonists/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Al-Bogami MM</b>, Alkhorayef M, Sulieman A, Bradley D, Jawad AS, Mageed RA. The clinical assessment of changes in bone density in rheumatoid arthritis patients': Role of DEXA scan and bone turnover biomarkers. <em class='incite-journal-name' onclick='ShowInCiteJournal(2672);'>Appl Radiat Isot</em> 2024;<b>211</b>:111373. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38851075' target='_blank'>38851075</a> DOI: <a href='https://dx.doi.org/10.1016/j.apradiso.2024.111373' target='_blank'>10.1016/j.apradiso.2024.111373</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.apradiso.2024.111373','38851075', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.apradiso.2024.111373' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2672);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.apradiso.2024.111373" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In addition to generalised of bone loss and a higher fracture risk, rheumatoid arthritis (RA) causes periarticular bone erosions. Improvements in bone density/erosion and turnover may not go hand in hand with a positive clinical response to biological anti-inflammatory drugs assesed by disease activity score 28 (DAS28) in RA patients. This study aimed to understand how biologic anti-inflammatory drugs affect bone density, erosion, and turnover in RA patients. We examined bone mineral density (BMD) and bone turnover biomarkers. The study population consisted of 62 RA patients, 49 (79%) of whom were female and 13 (21%) of whom were male. The patients ranged in age from 40 to 79 years old. The patients' BMD was measured using a DEXA scan, and their plasma levels of bone turnover biomarkers CTX and osteocalcin were quantified utilizing an ELISA. BMD of the hip and lumbar spine in responder patients rose after therapy by 0.001g/cm2 (0.11 percent, p0.001 vs. before treatment) and 0.0396g/cm2 (3.96 percent, p0.001 vs. before treatment), respectively. Clinically non-responder patients' DAS28 revealed minor reductions in hip BMD values of -0.008g/cm2 (-0.78 percent, p0.001 vs. before therapy), as well as an improvement in lumbar spine BMD of 0.03g/cm2 (3.03 percent, p0.001 vs. before treatment). After 12 weeks of therapy, the CTX levels in responder patients dropped from 164 125 pg/ml to 131 129 pg/ml. Osteocalcin levels in non-responder patients increased substantially from 11.6 ng/ml to 14.9 ng/ml after 12 weeks of therapy compared to baseline (p = 0.01). Treatment with biologic anti-inflammatory medicines decreases widespread bone loss in RA patients' hip and lumbar spine. The beneficial effects of therapy on BMD were not associated with changes in disease activity of RA patients. Changes in plasma levels of bone turnover biomarkers such as sCTX and osteocalcin confirmed the treatment's beneficial effects. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+scan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone scan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DEXA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DEXA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Absorptiometry%2c+Photon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Absorptiometry, Photon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteocalcin%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteocalcin/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen+Type+I%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen Type I/blood</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Kumar S</b>, Gild ML, McDonald MM, Kim AS, Clifton-Bligh RJ, Girgis CM. A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(169341);'>Osteoporos Int</em> 2024;<b>35</b>:1669-1675. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38839655' target='_blank'>38839655</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364616' target='_blank'>PMC11364616</a> DOI: <a href='https://dx.doi.org/10.1007/s00198-024-07139-9' target='_blank'>10.1007/s00198-024-07139-9</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00198-024-07139-9','38839655', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00198-024-07139-9' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169341);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/osin/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1007/s00198-024-07139-9" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In severe osteoporosis, the optimal approach for sequential treatment between denosumab and romosozumab is unclear. We utilised a novel overlapping strategy in three patients with very-high fracture risk despite long-term denosumab which led to greater bone density improvements than previously reported with standard approaches. Larger confirmatory prospective studies are needed. </div><div class="abstract-label">PURPOSE/INTRODUCTION</div><div class="abstract-content">In patients with severe osteoporosis, the optimal approach for sequential treatment between denosumab and romosozumab has not been established. The ideal strategy would maximise gains in bone mineral density (BMD) with romosozumab and effectively mitigate the risk of rebound increased bone turnover when sequencing from denosumab. Limited studies exploring the sequence from denosumab to romosozumab report only modest-to-no improvement in BMD and inadequate suppression of rebound bone turnover. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We describe three patients with severe osteoporosis and multiple fragility fractures despite long-term denosumab. A novel overlapping sequential treatment approach was utilised to maximise therapeutic benefit given these patients had a very high fracture risk. Romosozumab was commenced 3 months after the last denosumab dose. Instead of waiting until completion of romosozumab, denosumab was recommenced 6 months after commencing romosozumab in response to rising bone turnover markers. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Patients experienced a ~ 5-22% increase in lumbar spine BMD, and one patient had an 8% increase in total hip BMD after 12 months romosozumab. Serum bone turnover markers demonstrated an anabolic effect of romosozumab occurred despite overlapping treatment with denosumab. Recommencement of denosumab suppressed an increase in bone resorption in all cases. No new vertebral fractures occurred during this treatment. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">A novel overlapping sequential treatment approach between denosumab and romosozumab produced greater improvements in lumbar spine and hip BMD than previously reported with standard approaches. Larger prospective controlled studies are needed to confirm these findings and establish the optimal use of romosozumab in patients pre-treated with denosumab to maximise BMD gains and minimise fracture risk. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rebound%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rebound</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Romosozumab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Romosozumab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Denosumab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Denosumab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/therapeutic use</a></li><li><a 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href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Sydney%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Sydney</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Disha-Ibrahimi S</b>, Drevenšek G, Drevenšek M, Marc J, Žitnik IP. PPIA, HRPT1, and PGK1 genes as the appropriate combination for RT-qPCR normalization in alveolar and femoral bone remodeling in olanzapine-treated rats. <em>ACTA PHARMACEUTICA (ZAGREB, CROATIA)</em> 2024;<b>74</b>:511-524. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39279526' target='_blank'>39279526</a> DOI: <a href='https://dx.doi.org/10.2478/acph-2024-0029' target='_blank'>10.2478/acph-2024-0029</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2478/acph-2024-0029','39279526', 'Bone Remodeling/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.2478/acph-2024-0029" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Reliable gene expression analysis in bone remodeling studies requires an appropriate selection of internal controls, i.e. stable reference genes for the normalization of quantitative real-time PCR (RT-qPCR), the most common method used for quantifying gene expression measurements. Even the most widely used reference genes can have variable expression under different experimental conditions, or in different tissue types or treatment regimes, so selecting appropriate controls is a key step in ensuring reliable results. The aim of this research was to identify the most stable reference gene(s) for the study of olanzapine modulated bone remodeling in rats. RNA was isolated from the maxillary alveolar and femoral bones of olanzapine or placebo-treated Wistar rats and transcribed to cDNA. The expression of 12 candidate reference genes was assessed by RT-qPCR. Their expressions were analysed using GeNorm, NormFinder, BestKeeper and delta Ct algorithms, and by the comprehensive ranking method. PPIA, HRPT1 and PGK1 were the most stably expres sed reference genes and the combination of the three genes was optimal for normalization. This study is the first to identify the optimal reference genes for research in olanzapine-exposed rats, which serve as a pivotal benchmark for enhancing the accuracy and reliability of future RT-qPCR expression in bone studies. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RT-qPCR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RT-qPCR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22alveolar+bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">alveolar bone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22olanzapine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">olanzapine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rat%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rat</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reference+genes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reference genes</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Olanzapine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Olanzapine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a 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id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Bone Remodeling/drug effects (2291 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Bone Remodeling/drug effects (2291 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>