CINXE.COM

<!DOCTYPE html> <html> <head><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2312,1_50,1_53,1_51,0_2317-HCSds&p=3566a23a" /><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2214,1_16,0_2219,1_17-HCSds&p=3566a23a" /><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=0.3" /><link rel="shortcut icon" href="/favicon.ico" /><title> Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar </title><script src="/bundles/jquery?v=uFgEwkmfdwWoDMz6vEeIoql0PDF7uHxE-GEoIW9UY9M1"></script> <script src="/bundles/json2?v=d1Efh1-9UFdw-Pnj4VVUxViXmZK9H1kqbY_kx2U79DM1"></script> <script src="/bundles/site?v=Uby6LDuaSQ1_He97UGZvnGv_wln5mTgGNE3q1RwRMEQ1"></script> <link href="/Style/css?v=moasmn2BWK6Px64tnr4mMXZfX9KqyGOs6yBj9kZctxQ1" rel="stylesheet"/> <script src="/bundles/search?v=oKWBTbQ1Eyu3c78HTcS6WrXwgMWPpz68IXv5mSC3oqQ1"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-221132522-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', 'UA-221132522-1'); </script> <script type="text/javascript"> $(function () { InitCategoryIcon(); AddArticleSearchRecord(); }); </script> <meta name="application-name" content="ReferenceCitationAnalysis" /> <meta name="msapplication-TileColor" content="#bd4100" /> <meta name="description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta property="og:site" content="ReferenceCitationAnalysis" /> <meta property="og:site_name" content="ReferenceCitationAnalysis" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://referencecitationanalysis.com/" /> <meta property="og:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta property="og:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta name="twitter:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://referencecitationanalysis.com/" /> <meta name="twitter:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['form1']; if (!theForm) { theForm = document.form1; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDkCPVD1CEgIJIwX-djYyD12MdD7MbGguneDtbgL0T4_DTGNirF3uaaW3m5irAIXOA2&t=638628207619783110" type="text/javascript"></script> <script id="dxis_725862373" src="/DXR.axd?r=1_304-HCSds" type="text/javascript"></script><script id="dxis_117419880" src="/DXR.axd?r=1_185-HCSds" type="text/javascript"></script><script id="dxis_2117664241" src="/DXR.axd?r=1_188-HCSds" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="54D499A9" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" /> </div> <input type="hidden"/><script id="dxis_1899801520" src="/DXR.axd?r=1_298,1_211,1_221,1_182,1_277,1_198,1_209,1_217,1_190,1_223,1_208,1_290,1_206,1_288,1_212,1_286,1_296,1_299,1_224,1_201,1_216-HCSds" type="text/javascript"></script><table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="ASPxLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="width:0px;vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="ASPxLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="ASPxLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1948350305" type="text/javascript">  </script> <div class="top-part cl"> <div class="top-content" id="top"> <ul class="ul"> <li class="logo fl"> <a href="https://www.wjgnet.com" target="_blank"> <img src="/Contents/Images/Bpg-logo-new.svg" /> </a> </li> <li class="rca-title fl"> <a href="/" class="clearlink"> <img src="../Contents/Images/RCA-Logo.svg" alt="Reference Citation Analysis" /> </a> </li> <li id="PageTopControl_loginContainer" class="logined fr"> <table> <tr> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Login" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Login_I" class="dxb-hb" value="Login" type="submit" name="ctl00$PageTopControl$Login" /><span class="dx-vam">Login</span> </div> </div><script id="dxss_309739120" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_AuthorRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_AuthorRegist_I" class="dxb-hb" value="Scholar Register" type="submit" name="ctl00$PageTopControl$AuthorRegist" /><span class="dx-vam">Scholar Register</span> </div> </div><script id="dxss_216236472" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_BusinessRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_BusinessRegist_I" class="dxb-hb" value="Business Register" type="submit" name="ctl00$PageTopControl$BusinessRegist" /><span class="dx-vam">Business Register</span> </div> </div><script id="dxss_1760396766" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Subscribe" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Subscribe_I" class="dxb-hb" value="Subscribe" type="submit" name="ctl00$PageTopControl$Subscribe" /><span class="dx-vam">Subscribe</span> </div> </div><script id="dxss_1089838522" type="text/javascript">  </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="mesh" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="MESH Heading" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_153608340" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript">  </script><script id="dxss_14646264" type="text/javascript">  </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Ovariectomy" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55807943)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6160)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3725)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4648763)</span>   <a href="/TodayArticles" target="_self">Today's Articles (1078)</a>   <span>Subscriber (50767)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">16507</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (471)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (6352)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Ovariectomy</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Jiang T</b>, Li C, Li Y, Hu W, Guo J, Du X, Meng Q, Zhu X, Song W, Guo J, Su X. Multi-omics and bioinformatics for the investigation of therapeutic mechanism of roucongrong pill against postmenopausal osteoporosis. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118873. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39362330' target='_blank'>39362330</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118873' target='_blank'>10.1016/j.jep.2024.118873</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118873','39362330', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118873' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.jep.2024.118873" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">The Roucongrong Pill (RCRP), originating from the historical General Medical Collection of Royal Benevolence, is frequently used to treat postmenopausal osteoporosis (PMOP). Despite its prevalent application, the specific anti-osteoporotic mechanisms of RCRP remain to be elucidated. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">This study aims to elucidate the therapeutic mechanism of RCRP in the context of ovariectomy (OVX)-induced PMOP in rats. By employing an integrative approach, the research combines medicinal chemistry, gut microbiota (GM) profiling, metabolomics, MetOrigin traceability, network pharmacology, molecular docking, and molecular dynamics simulations to deliver a comprehensive analysis. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Sprague-Dawley (SD) rats underwent bilateral OVX to establish a PMOP model. The therapeutic efficacy of RCRP was evaluated through bone metrics (BMD, bone strength, BV/TV, Tb.Sp), hematoxylin and eosin (H&E) histological assessment, and bone metabolism markers (OPG, BALP, TRACP-5b, β-CTX, RANKL). Fecal metabolomics and 16S rDNA sequencing were employed to assess the influence of RCRP on GM and metabolite profiles. Furthermore, MetOrigin facilitated the traceability analysis of relevant metabolites. Molecular docking identified potential RCRP compounds with anti-PMOP activity, while their stability and protein interactions were assessed through molecular dynamics simulations. Network pharmacology further confirms the targets of action. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">RCRP alleviated PMOP in rats, enhancing bone strength, cortical and trabecular BMD, BV/TV, and serum OPG levels, while reducing Tb.Sp, serum BALP, TRACP-5b, β-CTX, and RANKL concentrations. A total of twenty-six distinct metabolites were identified, of which ten-tribufos, sulfoacetic acid, betamethasone dipropionate, 9-oxooctadeca-10,12,15-trienoic acid, menatetrenone, piperlongumine, maltopentaose, enol-phenylpyruvate, catechol, pentaacetate, and (+)-2-methylpropanoic acid-exhibited correlations with six GM species: Turicibacter, Roseburia, Colidextribacter, Helicobacter, Odoribacter, and Lachnoclostridium, as determined by Spearman's correlation analysis. Notably, MetOrigin revealed the microbial metabolism of taurine and hypotaurine, along with host-specific steroid hormone synthesis. Computational docking studies demonstrated robust interactions between five RCRP-derived steroids (hydroxyecdysone, corticosterone, trilostane, 5α-androstan-3,6,17-trione, and cortisol) and key enzymes (estradiol 17α-dehydrogenase and UDP-glucuronosyltransferase), suggesting a potential enhancement of therapeutic efficacy against PMOP. Furthermore, molecular dynamics simulations indicated stable interactions between hydroxyecdysone and two proteins, with binding free energies of -67.427 kJ/mol and -156.948 kJ/mol, respectively. Through network pharmacology and molecular docking approaches, potential targets of these metabolites were identified, including estrogen receptors ESR1 and ESR2, dual specificity phosphatase 6 (DUSP6), sex hormone-binding globulin (SHBG), prostaglandin E receptor 4 (PTGER4), cannabinoid receptor 2 (CNR2), cathepsin K (CTSK), and androgen receptor (AR). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">RCRP effectively mitigates OVX-induced bone loss in PMOP rats by modulating GM and associated metabolites, along with their potential targets and key metabolic pathways, including taurine and hypotaurine metabolism, as well as steroid hormone biosynthesis. These findings offer new insights into the therapeutic mechanisms by which RCRP may alleviate PMOP. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postmenopausal+osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postmenopausal osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Roucongrong+pill%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Roucongrong pill</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Steroid+hormone+biosynthesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Steroid hormone biosynthesis</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+Pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network Pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Dynamics+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Dynamics Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiomics</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Han Y</b>, Gao H, Gao J, Yang Y, He C. Low-intensity pulsed ultrasound regulates bone marrow mesenchymal stromal cells differentiation and inhibits bone loss by activating the IL-11-Wnt/β-catenin signaling pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113380. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39405933' target='_blank'>39405933</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113380' target='_blank'>10.1016/j.intimp.2024.113380</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113380','39405933', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113380' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.intimp.2024.113380" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Osteoporosis (OP) is a common metabolic bone disease. Low-intensity pulsed ultrasound (LIPUS) can effectively promote bone formation and fracture healing. The Wnt/β-catenin signaling pathway is crucial for regulating bone homeostasis and bone diseases, and its downregulation is one of the main mechanisms of osteoporosis pathogenesis. Interleukin-11 (IL-11), which is regulated by mechanical stress, is a key factor in bone remodeling. Here, we investigated the optimal intervention parameters for LIPUS, the relationships among LIPUS, IL-11, and the Wnt/β-catenin signaling pathway, and the effects of LIPUS on bone loss and potential molecular mechanisms in ovariectomized (OVX) mice. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Bone marrow mesenchymal stromal cells (BMSCs) were subjected to LIPUS intervention for 0, 10, or 20 min to determine the optimal intervention time. The mediating role of IL-11 in LIPUS intervention was explored through IL-11 knockdown and overexpression. Finally, animal experiments were conducted to investigate the in vivo therapeutic effects of LIPUS. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The optimal intervention time for LIPUS was 20 min. LIPUS promoted IL-11 expression and upregulated the Wnt/β-catenin signaling pathway, thereby promoting osteogenic differentiation and inhibiting adipogenic differentiation of BMSCs. IL-11 mediates the regulation of the Wnt/β-catenin signaling pathway by LIPUS. Additionally, LIPUS effectively improved the bone microstructure in ovariectomized mice, inhibited bone loss, promoted IL-11 expression in bone tissue, and activated the Wnt/β-catenin signaling pathway in the femur. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Low-intensity pulsed ultrasound can regulate BMSCs differentiation and inhibit bone loss by promoting IL-11 expression and activating the Wnt/β-catenin signaling pathway. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+marrow+mesenchymal+stromal+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone marrow mesenchymal stromal cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL-11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL-11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Low-intensity+pulsed+ultrasound%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Low-intensity pulsed ultrasound</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt%2f%ce%b2-Catenin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt/β-Catenin</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt+Signaling+Pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt Signaling Pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ultrasonic+Waves%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ultrasonic Waves</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-11%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-11/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ultrasonic+Therapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ultrasonic Therapy/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Du R</b>, Lu G, Luo WJ, He T, Li CL, Yu Y, Wei N, Luo X, Chen J. Dyadic social interaction paradigm reveals selective role of ovarian estrogen in the caring behavior and socially transferred pain in female mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(17736);'>Neuropharmacology</em> 2024;<b>261</b>:110138. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39244013' target='_blank'>39244013</a> DOI: <a href='https://dx.doi.org/10.1016/j.neuropharm.2024.110138' target='_blank'>10.1016/j.neuropharm.2024.110138</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neuropharm.2024.110138','39244013', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.neuropharm.2024.110138' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17736);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.neuropharm.2024.110138" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">When a naïve observer meets with a familiar conspecific in pain, mice may have a myriad of social (sniffing, allolicking, allogrooming, huddling) and non-social (self-grooming) behaviors under dyadic social interaction (DSI) paradigm. Unlike male, female observers express more allolicking behavior toward injury site of a familiar female in pain, but with less body allogrooming. In current study, we investigated roles of natural estrus cycle phases and ovarian estrogen in these behaviors and results showed that: (1) there was no changes in above behaviors in terms of latency, time and bouts across different natural estrus cycle phases in intact female. (2) however, ovariectomy (OVX) changed estrus cycle phases, lowered circulating level of ovarian estrogen, reduced time and bouts of allolicking behavior and increased time of self-grooming without affecting other behaviors. Moreover, OVX in observers decreased social buffering effect of DSI on spontaneous pain-related behavior in demonstrator relative to naïve and sham controls. (3) treatment of OVX-female with β-estradiol (E2) or progesterone (PROG) as replacement therapies, only E2 reversed impairment of allolicking behavior. (4) Additionally, socially transferred pain could be identified in intact female across all estrus cycle phases post-DSI, but disappeared in OVX-female, which could be reversed completely by E2 but not by PROG. (5) Finally, serum levels of estrogen, PROG, oxytocin, arginine vasopressin (AVP), prolactin, norepinephrine and 5-HT were examined by ELISA after E2, results showed only AVP level was significantly increased. These results suggest both injury site-targeted caring behavior and socially transferred pain are selectively dependent on ovarian estrogen. This article is part of the Special Issue on "Empathic Pain". </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caring+behavior%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caring behavior</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Empathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Empathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+replacement+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen replacement therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+estrogen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian estrogen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prosocial+behavior%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prosocial behavior</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Socially+transferred+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Socially transferred pain</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pain%2fpsychology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pain/psychology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Social+Interaction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Social Interaction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrous+Cycle%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrous Cycle/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Progesterone%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Progesterone/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovary%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovary/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arginine+Vasopressin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arginine Vasopressin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arginine+Vasopressin%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arginine Vasopressin/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Martínez-Magaña CJ</b>, Murbartián J. Estrogen receptor α regulates the IKKs/NF-kB activity involved in the development of mechanical allodynia induced by REM sleep deprivation in rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(4013);'>Brain Res</em> 2024;<b>1845</b>:149269. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39384127' target='_blank'>39384127</a> DOI: <a href='https://dx.doi.org/10.1016/j.brainres.2024.149269' target='_blank'>10.1016/j.brainres.2024.149269</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.brainres.2024.149269','39384127', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.brainres.2024.149269' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4013);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.brainres.2024.149269" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Several signaling pathways that converge in NF-kB activation have been linked to developing and maintaining different types of pathological pain. In addition, some mechanisms implied in the establishment of chronic pain have been demonstrated to have a sex-dependent correlation. This study aimed to determine if the IKKs/NF-kB signaling pathway is involved in establishing REM sleep deprivation (REMSD) induced mechanical allodynia in rats and its possible regulation depending on estradiol and estrogen receptors. Intrathecal administration of BMS-345541 or minocycline, two drugs that reduce the IKKs/NF-kB activity, avoided the development of mechanical allodynia in female but not in male rats subjected to 48 h of REMSD. Ovariectomy in female rats abolished the effect of BMS-345541 and minocycline. Meanwhile, the 17-β-estradiol restitution restored it. Intrathecal administration of MPP, a selective ERα antagonist, but not PHTPP, a selective ERβ antagonist, avoided the effect of BMS-345541 in female rats without hormonal manipulation. In addition, the transient run-down of ERα in female rats abolished the effect of BMS-345541. All data suggest an important role of ERα as a regulator of the IKKs/NF-kB activity. REMSD increased the ERα protein expression in the dorsal root ganglia and the dorsal spinal cord in females but not in male rats. Interestingly, ERα activation or ERα overexpression allowed the effect of BMS-345541 in male rats. Data suggest an important regulatory role of ERα in the IKKs/NF-kB activity on establishing mechanical allodynia induced by REMSD in female rats. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+receptor+%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen receptor α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IKK(A)%2fIKK(B)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IKK(A)/IKK(B)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mechanical+allodynia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mechanical allodynia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22REM+sleep+deprivation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">REM sleep deprivation</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperalgesia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperalgesia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+Deprivation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep Deprivation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+Deprivation%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep Deprivation/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+Receptor+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen Receptor alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22I-kappa+B+Kinase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">I-kappa B Kinase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Characteristics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Characteristics</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Li C</b>, Liu X, Chen X, Zhang J, Liao Y, Fan Z, Zhang X. Bu-Sui-Dan Enhances Osteoblast Differentiation by Upregulating VGLL4 to Counteract TEAD4-Mediated RUNX2 Transcription Suppression in Ovariectomized Rats. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2024;<b>335</b>:118690. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39142621' target='_blank'>39142621</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118690' target='_blank'>10.1016/j.jep.2024.118690</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118690','39142621', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118690' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.jep.2024.118690" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Postmenopausal osteoporosis (PMOP) has been considered as a major causative factor for bone-joint pain and inducing pathologic fractures. Bu-Sui-Dan (BSD), a classic ancient herbal formula, has been shown to exhibit osteoprotective effects by promoting bone marrow development and bone growth. However, the exact mechanism of BSD are still unexplored. </div><div class="abstract-label">AIM OF STUDY</div><div class="abstract-content">The study aimed to investigate the protective effect of BSD against osteoporotic injury, and to explore whether BSD regulated BMSCs' osteogenic differentiation by targeting VGLL4, which in turn improved PMOP. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">The anti-osteoporotic effect of BSD was studied in ovariectomized (OVX) rats and bone marrow mesenchymal stem cells (BMSCs). Micro-CT imaging and HE staining were performed, and the levels of osteogenic protein RUNX2 and osteogenesis-related factor VGLL4 were determined. Co-immunoprecipitation (Co-IP) was further employed to delve into the effects of BSD on the interactions between TEAD4 and RUNX2. The key osteogenic factors 1ALP, COLl1A1, and Osterix expression were detected by RT-qPCR. Co-IP and proximity ligation assay (PLA) were employed to scrutinize the influence of BSD on TEAD4 and RUNX2 inter-binding. Moreover, VGLL4 knockdown in BMSCs was conducted to confirm the role of VGLL4 in the therapeutic mechanism of BSD. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">BSD showed a dose-dependent protective effect against osteoporotic injury, as evidenced by improvement in bone volume, bone microarchitecture, and histomorphometry. Additionally, BSD treatment increased the levels of RUNX2 and its downstream target genes including ALP, COL1A1, and Osterix. Moreover, BSD upregulated VGLL4 expression and lessened TEAD4-RUNX2 interactions. In BMSCs experiment, BSD-containing serum could promote osteogenic differentiation of BMSCs, boosted the expression of osteogenesis-related factors and VGLL4 level. The knockdown of VGLL4 in BMSCs diminished the promotion effect of BSD in osteoblast differentiation, suggesting that VGLL4 play a vital role in the therapeutic effects exerted by BSD. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">BSD ameliorated osteoporosis injury and promoted osteoblast differentiation through upregulation of VGLL4 levels, which in turn antagonized TEAD4-mediated RUNX2 transcriptional repression. Our study implied that BSD may be an osteoporosis therapeutic agent. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bu-Sui-Dan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bu-Sui-Dan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblast+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblast differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postmenopausal+osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postmenopausal osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Runx2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Runx2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22VGLL4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">VGLL4</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Core+Binding+Factor+Alpha+1+Subunit%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Core Binding Factor Alpha 1 Subunit/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Core+Binding+Factor+Alpha+1+Subunit%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Core Binding Factor Alpha 1 Subunit/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Up-Regulation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Up-Regulation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TEA+Domain+Transcription+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TEA Domain Transcription Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Orban E</b>, Pap Z, Sipos RS, Fechete R. Assessment of bone tissue cytoarchitectonics by 2D <sup>1</sup>H NMR relaxometry maps. <em class='incite-journal-name' onclick='ShowInCiteJournal(12373);'>J Biol Phys</em> 2024;<b>50</b>:255-269. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38935192' target='_blank'>38935192</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492200' target='_blank'>PMC11492200</a> DOI: <a href='https://dx.doi.org/10.1007/s10867-024-09658-2' target='_blank'>10.1007/s10867-024-09658-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10867-024-09658-2','38935192', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s10867-024-09658-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12373);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1007/s10867-024-09658-2" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Bone is a complex tissue that fulfills the role of a resistance structure. This quality is most commonly assessed by bone densitometry, but bone strength may not only be related to bone mineral density but also to the preservation of bone cytoarchitectonics. The study included two groups of rats, ovariectomized and non-ovariectomized. Each group was divided into three batches: control, simvastatin-treated, and fenofibrate-treated. In the ovariectomized group, hypolipidemic treatment was instituted at 12 weeks post ovariectomy. One rat from each of the 6 batches was sacrificed 8 weeks after the start of treatment in the group. The experimental study was performed using a Bruker Minispec mq 20 spectrometer operating at a frequency of 20 MHz, subsequently also performed by 1H T2-T2 molecular exchange maps. The results were represented by T2-T2 molecular exchange maps that showed, comparatively, both pore size and their interconnectivity at the level of the femoral epiphysis, being able to evaluate both the effect of estrogen on bone tissue biology and the effect of the lipid-lowering medication, simvastatin, and fenofibrate, in both the presence and absence of estrogen. T2-T2 molecular exchange maps showed that the absence of estrogen results in an increase in bone tissue pore size and interconnectivity. In the presence of estrogen, lipid-lowering medication, both simvastatin and fenofibrate alter bone tissue cytoarchitectonics by reducing pore interconnectivity. In the absence of estrogen, fenofibrate improves bone tissue cytoarchitectonics, the T2-T2 molecular exchange map being similar to that of non-osteoporotic bone tissue. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cn++++++++++++++++++++++++1H+NMR+relaxometry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> 1H NMR relaxometry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fenofibrate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fenofibrate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pore+connectivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pore connectivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Simvastatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Simvastatin</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Simvastatin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Simvastatin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fenofibrate%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fenofibrate/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proton+Magnetic+Resonance+Spectroscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proton Magnetic Resonance Spectroscopy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Wang D</b>, Wang J, Yu Z, Yao R, Zhang J, Zhao X. Quercetin Alleviates Perimenopausal Depression Induced by <span class="highlight-field">Ovariectomy</span> Combined with Chronic Unpredictable Mild Stress Through Regulating Serum Elements and Inhibiting Ferroptosis in Prefrontal Cortex of Rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(3589);'>Biol Trace Elem Res</em> 2024;<b>202</b>:5596-5611. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38388751' target='_blank'>38388751</a> DOI: <a href='https://dx.doi.org/10.1007/s12011-024-04106-7' target='_blank'>10.1007/s12011-024-04106-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12011-024-04106-7','38388751', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12011-024-04106-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3589);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://submission.nature.com/new-submission/12011/3' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1007/s12011-024-04106-7" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study investigated the effects of quercetin on the alterations of serum elements in perimenopausal depression rat model induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS) and possible mechanisms. According to the results of the sucrose preference test, the rats were randomly assigned to four groups: sham, OVX-CUMS, OVX-CUMS + 17β-estradiol (17β-estradiol: 0.27 mg/kg.bw), and OVX-CUMS + Quercetin (Quercetin: 50 mg/kg.bw). At the end of experiment, serum and prefrontal cortex of rats were collected. The inductively coupled plasma mass spectrometry (ICP-MS) analysis showed that levels of calcium (Ca), magnesium (Mg), selenium (Se), cobalt (Co) and zinc (Zn) decreased, and levels of iron (Fe) and copper (Cu) increased in serum and prefrontal cortex of OVX-CUMS rats compared with sham group (p < 0.01). Meanwhile, the levels of the above elements in prefrontal cortex had correlation with behavioral characteristics in OVX-CUMS rats (p < 0.05 or p < 0.01). The abnormal elements in serum may cross blood-brain-barrier into the brain and induce oxidative stress, leading to ferroptosis. Furtherly, the expressions of ferroptosis-related protein including GPX4 and SLC7A11 were decreased in prefrontal cortex of OVX-CUMS rats (p < 0.01), which confirmed the above results. Quercetin treatment restored the above abnormal indicators (p < 0.05 or p < 0.01) induced by OVX-CUMS in rats. Our study suggested that quercetin regulated variation of elements in serum and prefrontal cortex, further inhibiting ferroptosis in prefrontal cortex through alleviating oxidative stress in OVX-CUMS rats. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elements%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elements</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ICP-MS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ICP-MS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OVX-CUMS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OVX-CUMS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Quercetin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Quercetin</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Quercetin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Quercetin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prefrontal+Cortex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prefrontal Cortex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prefrontal+Cortex%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prefrontal Cortex/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Selenium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Selenium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82373560 National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Cervera-Juanes R</b>, Zimmerman KD, Wilhelm L, Zhu D, Bodie J, Kohama SG, Urbanski HF. Modulation of neural gene networks by estradiol in old rhesus macaque females. <em class='incite-journal-name' onclick='ShowInCiteJournal(9932);'>GeroScience</em> 2024;<b>46</b>:5819-5841. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38509416' target='_blank'>38509416</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493911' target='_blank'>PMC11493911</a> DOI: <a href='https://dx.doi.org/10.1007/s11357-024-01133-z' target='_blank'>10.1007/s11357-024-01133-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s11357-024-01133-z','38509416', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s11357-024-01133-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9932);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s11357-024-01133-z" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene expression and DNA methylation (DNAm) patterns in the nonhuman primate brain following ovariectomy (Ov) and subsequent subcutaneous bioidentical E2 chronic treatment. We identified several dysregulated molecular networks, including MAPK signaling and dopaminergic synapse response, that are associated with ovariectomy and shared across two different brain areas, the occipital cortex (OC) and prefrontal cortex (PFC). The finding that hypomethylation (p = 1.6 × 10-51) and upregulation (p = 3.8 × 10-3) of UBE2M across both brain regions provide strong evidence for molecular differences in the brain induced by E2 depletion. Additionally, differential expression (p = 1.9 × 10-4; interaction p = 3.5 × 10-2) of LTBR in the PFC provides further support for the role E2 plays in the brain, by demonstrating that the regulation of some genes that are altered by ovariectomy may also be modulated by Ov followed by hormone replacement therapy (HRT). These results present real opportunities to understand the specific biological mechanisms that are altered with depleted E2. Given E2's potential role in cognitive decline and neuroinflammation, our findings could lead to the discovery of novel therapeutics to slow cognitive decline. Together, this work represents a major step toward understanding molecular changes in the brain that are caused by ovariectomy and how E2 treatment may revert or protect against the negative neuro-related consequences caused by a depletion in estrogen as women approach menopause. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Occipital+cortex%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Occipital cortex</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prefrontal+cortex%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prefrontal cortex</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Seq%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Seq</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macaca+mulatta%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macaca mulatta</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+Methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA Methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Regulatory+Networks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Regulatory Networks</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prefrontal+Cortex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prefrontal Cortex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prefrontal+Cortex%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prefrontal Cortex/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P51 OD011092 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 AG066518 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P51 OD011092 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RF1 AG062220 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RF1 AG062220 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 AG066518 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P51 OD011092 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institute+on+Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Institute on Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wake+Forest+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wake Forest University</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Wong CA</b>, Sanchez-Rodriguez G, Ethier CR, Wood LB, Feola AJ. <span class="highlight-field">Ovariectomy</span> drives increase of an ECM transcription signature in the posterior eye and retina. <em class='incite-journal-name' onclick='ShowInCiteJournal(23412);'>Vision Res</em> 2024;<b>225</b>:108507. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39476526' target='_blank'>39476526</a> DOI: <a href='https://dx.doi.org/10.1016/j.visres.2024.108507' target='_blank'>10.1016/j.visres.2024.108507</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.visres.2024.108507','39476526', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.visres.2024.108507' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23412);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.visres.2024.108507" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Increased risk of developing glaucoma has recently been associated with early age of menopause. Here, we examined how age and surgically-induced menopause via ovariectomy (OVX) impacted gene expression in gene pathways previously linked to glaucoma, such as extracellular matrix (ECM) remodeling and TGF-β signaling. Using bulk RNA sequencing, we analyzed changes in young (3-4 months) and middle-aged (9-10 months) Long-Evans rats. We focused on posterior pole tissues (sclera and optic nerve head) but also examined the retina to compare observed changes across different tissue regions. Our results demonstrated that aging and OVX significantly alter gene expression in the sclera and optic nerve head. Generally, OVX triggered the enrichment of immune-related processes. However, OVX in young rats also led to significant enrichment of ECM and TGF-β gene sets. At the same time, these effects were diminished in middle-aged rats, indicating an age dependency of the effects of OVX on matrix-related pathways. Notably, the transcriptional factor Fos was downregulated in the posterior eye and retina in aged and OVX animals. Fos is a major regulator of cell proliferation and survival, and its dysregulation may play an important role in aging and menopause for women. These findings underscore the important role of menopause timing in modulating molecular pathways associated with glaucoma, which is consistent with clinical studies showing that early menopause may heighten the risk of developing this condition. This study also highlights the importance of considering women's health factors, such as menopause, in understanding and managing glaucoma risk. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glaucoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glaucoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menopause%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menopause</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Long-Evans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Long-Evans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retina%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retina/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Matrix%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Matrix/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Optic+Disk%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Optic Disk/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glaucoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glaucoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glaucoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glaucoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glaucoma%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glaucoma/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Rossetti CL</b>, Andrade IS, Fonte Boa LF, Neves MB, Fassarella LB, Bertasso IM, Souza MDGCD, Bouskela E, Lisboa PC, Takyia CM, Trevenzoli IH, Fortunato RS, Carvalho DPD. Liraglutide prevents body and fat mass gain in ovariectomized Wistar rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(17380);'>Mol Cell Endocrinol</em> 2024;<b>594</b>:112374. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39306226' target='_blank'>39306226</a> DOI: <a href='https://dx.doi.org/10.1016/j.mce.2024.112374' target='_blank'>10.1016/j.mce.2024.112374</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.mce.2024.112374','39306226', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.mce.2024.112374' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17380);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/mce/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.mce.2024.112374" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Estrogens exert beneficial metabolic effects by reducing food intake and enhancing energy expenditure through both central and peripheral mechanisms. The decrease of estrogen, as occurs in ovariectomy (OVX), leads to metabolic disturbances, such as increased body weight, adipose tissue mass, basal blood glucose, and impaired glucose tolerance. These effects can be reversed by reintroducing estrogen. GLP-1 and its receptor agonists, known for their antihyperglycemic properties, also exhibit anorexigenic effects. Besides that, research indicates that GLP-1 analogs can induce metabolic changes peripherally, such as increased fatty acid oxidation and inhibited lipogenesis. Given the shared metabolic actions of GLP-1 and estrogens, we explored whether liraglutide, a GLP-1 agonist, could mitigate the metabolic effects of estrogen deficiency. We tested this hypothesis using ovariectomized rats, a model that simulates menopausal estrogen deficiency, and treated them with either liraglutide or 17β-Estradiol benzoate for 21 days. Ovariectomy resulted in elevated DPP-IV activity in both plasma and inguinal white adipose tissue (iWAT). While estrogen replacement effectively countered the DPP-IV increase in both plasma and iWAT, liraglutide only prevented the rise in iWAT DPP-IV activity. Liraglutide prevented body weight and fat mass gain after ovariectomy to the same extent as estradiol treatment. This can be explained by the lower food intake and food efficiency caused by estradiol and liraglutide. However, liraglutide was associated with increased pro-inflammatory cytokines and inflammatory cells in white adipose tissue. Further research is crucial to fully understand the potential benefits and risks of using GLP-1 receptor agonists in the context of menopause. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DPP-IV%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DPP-IV</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liraglutide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liraglutide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+adipose+tissue%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White adipose tissue</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liraglutide%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liraglutide/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Body+Weight%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Body Weight/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2c+White%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue, White/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2c+White%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue, White/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adiposity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adiposity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Weight+Gain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Weight Gain/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Cepeda SB</b>, Cutini PH, Valle MI, Campelo AE, Massheimer VL, Sandoval MJ. Bone action of the phytoestrogen genistein under hypoestrogenism and obesity. <em class='incite-journal-name' onclick='ShowInCiteJournal(17380);'>Mol Cell Endocrinol</em> 2024;<b>594</b>:112388. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39419340' target='_blank'>39419340</a> DOI: <a href='https://dx.doi.org/10.1016/j.mce.2024.112388' target='_blank'>10.1016/j.mce.2024.112388</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.mce.2024.112388','39419340', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.mce.2024.112388' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17380);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/mce/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.mce.2024.112388" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoporosis and obesity are prevalent diseases in menopause. The phytoestrogen genistein (Gen) is an antioxidant/anti-inflammatory agent proposed as natural therapy to counteract syndromes associated to menopause. In this work we evaluated the bone effect of Gen in a stress environment induced by hypoestrogenism and obesity. Bilaterally ovariectomized female Wistar rats were fed with high-fat diet (obese), or standard diet (non-obese). Osteoblasts (OB) primary cultures from femoral shafts, and retroperitoneal explants of white adipose tissue (WAT) in vitro exposed to Gen were employed as experimental systems. In obese rats, bone oxidative stress revealed by enhancement on H2O2 release, and significant reduction in OB nitric oxide (NO) production, cell growth, alkaline phosphatase activity (ALP), matrix mineralization and collagen deposition was detected. In OB-WAT co-cultures, Gen treatment inhibited H2O2 secretion, and prompted OB differentiation. A direct action of Gen on WAT was demonstrated. The phytoestrogen inhibited H2O2 and TBARS production, and diminished the secretion of the inflammatory adipokine leptin, through a mechanism of action mediated by estrogen receptor (ER) involvement, and MAPK and PI3K signal transduction pathways participation. A directional interaction from WAT to bone was evidenced by the incubation OB with conditioned medium obtained from WAT exposed to Gen (Gen-CM). The presence of Gen-CM improved OB growth, and reduced H2O2 production. The antioxidative effect of Gen on obese bone cells was partially dependent on its ability to reduce leptin secretion by WAT. Altogether, the results suggest that, under obesity, Gen may improve bone metabolism through a direct action on WAT. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genistein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genistein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genistein%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genistein/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phytoestrogens%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phytoestrogens/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen+Peroxide%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen Peroxide/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2c+White%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue, White/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2c+White%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue, White/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Estrogen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Estrogen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leptin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leptin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitric+Oxide%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitric Oxide/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Liang B</b>, Chen X, Li M, Zhang L, Yang X, Shi L, Gong Y, Gong Y, Xu H, Wu X, Jin Z, Wang Y, Liu L, Yi X, Xie L, Zhong H, Shen C, Wang Y, Yang L. Liuwei Dihuang pills attenuate <span class="highlight-field">ovariectomy</span>-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis. <em>PHARMACEUTICAL BIOLOGY</em> 2024;<b>62</b>:42-52. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38112463' target='_blank'>38112463</a> DOI: <a href='https://dx.doi.org/10.1080/13880209.2023.2291675' target='_blank'>10.1080/13880209.2023.2291675</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/13880209.2023.2291675','38112463', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/13880209.2023.2291675' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/21/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1080/13880209.2023.2291675" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">CONTEXT</div><div class="abstract-content">Liuwei Dihuang pill (LWDH) has been used to treat postmenopausal osteoporosis (PMOP). </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To explore the effects and mechanisms of action of LWDH in PMOP. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Forty-eight female Sprague-Dawley rats were divided into four groups: sham-operated (SHAM), ovariectomized (OVX), LWDH high dose (LWDH-H, 1.6 g/kg/d) and LWDH low dose (LWDH-L, 0.8 g/kg/d); the doses were administered after ovariectomy via gavage for eight weeks. After eight weeks, the bone microarchitecture was evaluated. The effect of LWDH on the differentiation of bone marrow mesenchymal stem cells (BMSCs) was assessed via osteogenesis- and lipogenesis-induced BMSC differentiation. The senescence-related biological indices were also detected using senescence staining, cell cycle analysis, quantitative real-time polymerase chain reaction and western blotting. Finally, the expression levels of autophagy-related proteins and Yes-associated protein (YAP) were evaluated. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">LWDH-L and LWDH-H significantly modified OVX-induced bone loss. LWDH promoted osteogenesis and inhibited adipogenesis in OVX-BMSCs. Additionally, LWDH decreased the positive ratio of senescence OVX-BMSCs and improved cell viability, cell cycle, and the mRNA and protein levels of p53 and p21. LWDH upregulated the expression of autophagy-related proteins, LC3, Beclin1 and YAP, in OVX-BMSCs and downregulated the expression of p62. </div><div class="abstract-label">DISCUSSION AND CONCLUSIONS</div><div class="abstract-content">LWDH improves osteoporosis by delaying the BMSC senescence through the YAP-autophagy axis. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Traditional+Chinese+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Traditional Chinese medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22postmenopausal+osteoporosis+(P+MOP)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">postmenopausal osteoporosis (P MOP)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">senescence</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Proteins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Proteins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22YAP-Signaling+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YAP-Signaling Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Yang Y</b>, Liu H, Hu J, Ma Y, Li P, Zhang Z, Chen Y. Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(2141);'>Ann Med</em> 2024;<b>56</b>:2411013. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39382555' target='_blank'>39382555</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465370' target='_blank'>PMC11465370</a> DOI: <a href='https://dx.doi.org/10.1080/07853890.2024.2411013' target='_blank'>10.1080/07853890.2024.2411013</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/07853890.2024.2411013','39382555', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/07853890.2024.2411013' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2141);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rp.tandfonline.com/submission/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1080/07853890.2024.2411013" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Erxian decoction (EXD) is an empirical formula for treating cardiovascular disease, our previous work has shown that EXD could improve the cardiovascular structure and function in ovariectomized (OVX) rats, but its pharmacological mechanism is still unclear. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Network pharmacology was utilized to assess the key active components and central targets of EXD in treating postmenopausal cardiovascular disease. Then, an OVX rat model was established, HE staining and transmission electron microscope were utilized to observe myocardial tissue morphology, TUNEL staining was utilized to detect cardiomyocyte apoptosis, western blot, and ELISA were used to confirm efficacy and pathway of EXD. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The network pharmacology prediction results showed that 129 common targets were identified by intersecting EXD targets and postmenopausal cardiovascular disease targets, including AKT1, TNF, IL-6, IL-1β, PTGS2 and other core targets, apoptosis, PI3K/AKT, and other signaling pathways may be closely related to postmenopausal cardiovascular disease. After ovariectomy, the myocardial tissue of rats was damaged, the expression level of PI3K/AKT pathway-related molecules in the myocardial tissue were decreased, the apoptosis index of cardiomyocytes was increased, and the levels of inflammatory factors (TNF-α, IL-6, and IL-1β) were enhanced. EXD intervention could improve myocardial tissue injury, EXD could up-regulate the protein expression of PI3K and p-AKT in myocardial tissue, and thereby prevent myocardial cell apoptosis. At the same time, EXD downregulated the levels of inflammatory factors in serum of ovariectomized rats. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">EXD may prevent myocardial tissue damage through induction of the PI3K/AKT signaling pathway, thereby reducing cardiomyocyte apoptosis and inflammation. EXD may be a potential drug for the treatment of postmenopausal cardiovascular disease. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Erxian+decoction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Erxian decoction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PI3K%2fAKT+signaling+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI3K/AKT signaling pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammatory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammatory</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+docking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular docking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22myocardial+apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">myocardial apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">network pharmacology</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphatidylinositol+3-Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphatidylinositol 3-Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardium%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardium/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Cardiac%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Cardiac/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Cardiac%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Cardiac/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+Pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network Pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/prevention & control</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Mettwally WSA</b>, Hussein RA, Abdel Jaleel GA, Hassan A, Saleh DO, El-Beih AA. Cardenolides; calotropin and gomphogenin from Calotropis procera (Aiton) mitigate bone turnover in ovariectomized osteoporotic rats: Targeting RANKL/OPG axis and estrogen receptor-alpha. <em class='incite-journal-name' onclick='ShowInCiteJournal(9147);'>Fitoterapia</em> 2024;<b>179</b>:106226. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321857' target='_blank'>39321857</a> DOI: <a href='https://dx.doi.org/10.1016/j.fitote.2024.106226' target='_blank'>10.1016/j.fitote.2024.106226</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fitote.2024.106226','39321857', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fitote.2024.106226' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9147);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.fitote.2024.106226" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The present study aimed to examine the effect of Calotropis procera (Aiton) and its major cardenolides; calotropin and gomphogenin on ovariectomy-induced osteoporosis in rats. Osteoporotic rats were orally treated with C. procera alcoholic extract (100 mg/kg), calotropin (CLT; 100 μg/kg) and gomphogenin (GPG; 100 μg/kg) for 14 consecutive days. Bone resorption/formation biomarkers; bone specific alkaline phosphatase (BALP), osteoprotegerin (OPG) and nuclear factor-κβ ligand (RANKL) as well as serum calcium and phosphorus were assessed 24 h after last doses of treatments. Serum levels of estradiol (E2) and catalase were also measured. Oral treatment with C. procera extract, CLT and GPG caused E2 restoration to normal level with a marked regulation in the RANKL/OPG axis. Serum phosphorus and calcium were up-leveled whereas BALP was downregulated. Histopathological examination, bone histomorphometric analysis and immunohistochemical staining for osteopontin (OPN) inspection further emphasized the aforementioned outcomes. The results revealed the superiority of CLT and to a lesser extent GPG osteoporotic effect over C. procera extract. Molecular docking of the two compounds on ER-α and RANKL/OPG complex showed noteworthy binding affinities which also confirmed the supremacy of CLT due to the additional hydrogen bonding of the hydroxyl groups of the sugar moiety with RANKL/OPG complex. Finally, it is concluded that CLT and GPG from C. procera hinder bone turnover by decreasing osteoclastic bone cells activity and increasing calcium mineralization thus suppressing bone remodeling and preventing bone infirmity in OVX osteoporotic rats directly via binding to RANKL/OPG complex and ER-α and indirectly through elevating level of E2. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropis+procera%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropis procera</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ER-%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ER-α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gomphogenin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gomphogenin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANKL%2fOPG+complex%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANKL/OPG complex</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calotropis%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calotropis/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoprotegerin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoprotegerin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+Receptor+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen Receptor alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardenolides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardenolides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardenolides%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardenolides/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Structure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Structure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteopontin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteopontin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cycloheptanes%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cycloheptanes/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cycloheptanes%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cycloheptanes/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phytochemicals%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phytochemicals/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phytochemicals%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phytochemicals/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzoates%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzoates</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bridged+Bicyclo+Compounds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bridged Bicyclo Compounds</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sesquiterpenes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sesquiterpenes</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Kassey VB</b>, Walle M, Egan J, Yeritsyan D, Beeram I, Kassey SP, Wu Y, Snyder BD, Rodriguez EK, Ackerman JL, Nazarian A. Quantitative <sup>1</sup>H Magnetic Resonance Imaging on Normal and Pathologic Rat Bones by Solid-State <sup>1</sup>H ZTE Sequence with Water and Fat Suppression. <em class='incite-journal-name' onclick='ShowInCiteJournal(169294);'>J Magn Reson Imaging</em> 2024;<b>60</b>:2423-2432. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38526032' target='_blank'>38526032</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422519' target='_blank'>PMC11422519</a> DOI: <a href='https://dx.doi.org/10.1002/jmri.29361' target='_blank'>10.1002/jmri.29361</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jmri.29361','38526032', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jmri.29361' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169294);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/26/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1002/jmri.29361" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Osteoporosis (OP) and osteomalacia (OM) are metabolic bone diseases characterized by mineral and matrix density changes. Quantitative bone matrix density differentiates OM from OP. MRI is a noninvasive and nonionizing imaging technique that can measure bone matrix density quantitatively in ex vivo and in vivo. </div><div class="abstract-label">PURPOSE</div><div class="abstract-content">To demonstrate water + fat suppressed 1H MRI to compute bone matrix density in ex vivo rat femurs in the preclinical model. </div><div class="abstract-label">STUDY TYPE</div><div class="abstract-content">Prospective. </div><div class="abstract-label">ANIMAL MODEL</div><div class="abstract-content">Fifteen skeletally mature female Sprague-Dawley rats, five per group (normal, ovariectomized (OVX), partially nephrectomized/vitamin D (Vit-D) deficient), 250-275 g, ∼15 weeks old. </div><div class="abstract-label">FIELD STRENGTH/SEQUENCE</div><div class="abstract-content">7T, zero echo time sequence with water + fat (VAPOR) suppression capability, μCT imaging, and gravimetric measurements. </div><div class="abstract-label">ASSESSMENT</div><div class="abstract-content">Cortical and trabecular bone segments from normal and disease models were scanned in the same coil along with a dual calibration phantom for quantitative assessment of bone matrix density. </div><div class="abstract-label">STATISTICAL TESTS</div><div class="abstract-content">ANOVA and linear regression were used for data analysis, with P-values <0.05 statistically significant. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The MRI-derived three-density PEG pellet densities have a strong linear relationship with physical density measures (r2 = 0.99). The Vit-D group had the lowest bone matrix density for cortical bone (0.47 ± 0.16 g cm-3), whereas the OVX had the lowest bone matrix density for trabecular bone (0.26 ± 0.04 g cm-3). Gravimetry results confirmed these MRI-based observations for Vit-D cortical (0.51 ± 0.07 g cm-3) and OVX trabecular (0.26 ± 0.03 g cm-3) bone groups. </div><div class="abstract-label">DATA CONCLUSION</div><div class="abstract-content">Rat femur images were obtained using a modified pulse sequence and a custom-designed double-tuned (1H/31P) transmit-receive solenoid-coil on a 7T preclinical MRI scanner. Phantom experiments confirmed a strong linear relation between MRI-derived and physical density measures and quantitative bone matrix densities in rat femurs from normal, OVX, and Vit-D deficient/partially nephrectomized animals were computed. </div><div class="abstract-label">LEVEL OF EVIDENCE</div><div class="abstract-content">2 TECHNICAL EFFICACY: Stage 2. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+matrix+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone matrix density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+mineral+density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone mineral density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteomalacia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteomalacia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22short%e2%80%90T2+solid%e2%80%90state+MRI%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">short‐T2 solid‐state MRI</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phantoms%2c+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phantoms, Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteomalacia%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteomalacia/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Image+Processing%2c+Computer-Assisted%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Image Processing, Computer-Assisted/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22X-Ray+Microtomography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">X-Ray Microtomography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">K99 AR057093 NIAMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R00 AR057093 NIAMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">K99/R00 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AR057093 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BIDMC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BIDMC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AR057093 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">K99/R00 NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Boston+Children%27s+Hospital%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Boston Children's Hospital</a></li></ul> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Stute P</b>, Henneicke-von Zepelin HH, Nicken P. Transfer of preclinical study data on the influence of <i>cimicifuga racemosa</i>on functional changes in the hippocampus during menopause. <em class='incite-journal-name' onclick='ShowInCiteJournal(169481);'>Gynecol Endocrinol</em> 2024;<b>40</b>:2360066. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38833172' target='_blank'>38833172</a> DOI: <a href='https://dx.doi.org/10.1080/09513590.2024.2360066' target='_blank'>10.1080/09513590.2024.2360066</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/09513590.2024.2360066','38833172', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/09513590.2024.2360066' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169481);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rp.tandfonline.com/submission/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/06/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1080/09513590.2024.2360066" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. Hormone replacement therapy is the first-line treatment. However, many women are reluctant to use HRT or have contraindications toward HRT and seek for alternatives. Non-hormonal therapies with extracts of Cimicifuga racemosa rhizomes like the isopropanolic extract (iCR, black cohosh) offer a promising alternative. A preclinical pilot study exploring iCR's effects on gene expression in the hippocampus and hypothalamus of ovarectomized (OVX) rats mimicking menopausal conditions identified important signaling pathways and CNS-based contributions to the multitargeted modes of action of iCR. Especially in the hippocampus, iCR compensated effects of OVX on gene expression profiles. These changes are reflected by the genes AVPR1A, GAL, CALCA, HCRT, PNOC, ESR1, ESR2 and TAC3 contributing to the formation of hot flushes or thermoregulation as well as to secondary effects such as blood pressure, metabolism, hormonal regulation, homeostasis, mood regulation, neuroendocrine modulation, regulation of sleep and arousal, and in learning, memory and cognition. To understand the mechanisms in the brain of estrogen-depressed animals (OVX) and subsequent iCR treatment we combined the results of the pilot study with those of up-to-date literature and tried to transfer the current knowledge to humans during menopausal transition and adaptation. Focus was laid on changes in the hippocampal function, that is disturbed by hormonal fluctuations, but can also be brought back into balance by iCR. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cimicifuga+racemosa%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cimicifuga racemosa</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22black+cohosh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">black cohosh</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hippocampus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hippocampus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22menopause%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">menopause</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mode+of+action%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mode of action</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cimicifuga%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cimicifuga/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menopause%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menopause/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pilot+Projects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pilot Projects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Hu Y</b>, Hou Z, Liu Z, Wang X, Zhong J, Li J, Guo X, Ruan C, Sang H, Zhu B. Oyster mantle-derived exosomes alleviate osteoporosis by regulating bone homeostasis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2024;<b>311</b>:122648. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38833761' target='_blank'>38833761</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122648' target='_blank'>10.1016/j.biomaterials.2024.122648</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122648','38833761', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122648' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.biomaterials.2024.122648" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoporosis is a major public health problem with an urgent need for safe and effective therapeutic interventions. The process of shell formation in oysters is similar to that of bone formation in mammals, and oyster extracts have been proven to exert osteoprotective effects. Oyster mantle is the most crucial organ regulating shell formation, in which exosomes play an important role. However, the effects of oyster mantle-derived exosomes (OMEs) on mammalian osteoporosis and the underlying mechanisms remain unknown. The OMEs investigated herein was found to carry abundant osteogenic cargos. They could also survive hostile gastrointestinal conditions and accumulate in the bones following oral administration. Moreover, they promoted osteoblastic differentiation and inhibited osteoclastic differentiation simultaneously. Further mechanistic examination revealed that OMEs likely promoted osteogenic activity by activating PI3K/Akt/β-catenin pathway in osteoblasts and blunted osteoclastic activity by inhibiting NF-κB pathway in osteoclasts. These favorable pro-osteogenic effects of OMEs were also corroborated in a rat femur defect model. Importantly, oral administration of OMEs effectively attenuated bone loss and improved the bone microstructure in ovariectomy-induced osteoporotic mice, and demonstrating excellent biosafety. The mechanistic insights from our data support that OMEs possess promising therapeutic potential against osteoporosis. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oyster%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oyster</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ostreidae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ostreidae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animal+Shells%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animal Shells/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Liang G</b>, Kow ASF, Lee YZ, Yusof R, Tham CL, Ho YC, Lee MT. Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>734</b>:150443. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39088981' target='_blank'>39088981</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150443' target='_blank'>10.1016/j.bbrc.2024.150443</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150443','39088981', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150443' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.bbrc.2024.150443" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Menopause-associated mood disorder is characterized by emotional depression, anxiety, and stress, which accompany hypogonadism in women in the menopausal phase. The current treatment for menopause-associated mood disorder provides only symptomatic relief and is associated with many side effects. Supplementation with vitamin E has been shown to be effective in ameliorating anxiety and depression. However, the effects of vitamin E and its underlying mechanism in ameliorating menopause-associated mood disorders remain uncertain. This work evaluated the effects of α-tocopherol and tocotrienol-rich palm oil extract on depressive and anxiety-related phenotypes induced by estrogen deficiency through ovariectomy in mice. Our study revealed that ovariectomized mice exhibited alterations in behavior indicative of depressive- and anxiety-like behaviors. The serum corticosterone level, a glucocorticoid hormone associated with stress, was found to be elevated in ovariectomized mice as compared to the sham group. Oral administration of α-tocopherol (50 and 100 mg/kg) and tocotrienol-rich palm oil extract (100 and 200 mg/kg) for 14 days alleviated these behavioral changes, as observed in open field, social interaction, and tail suspension tests. However, treatment with tocotrienol-rich palm oil extract, but not α-tocopherol, modulated the depressive- and anxiety-like responses in ovariectomized mice subjected to chronic restraint stress. Both treatments suppressed the elevated serum corticosterone level. Our findings suggested that α-tocopherol and tocotrienol-rich palm oil extract alleviated menopause-associated mood disorder, at least in part, by modulating the hypothalamic-pituitary-adrenal (HPA) axis. The findings of this study can provide a new foundation for the treatment of menopause-associated depressive- and anxiety-like phenotypes, for the betterment of psychological wellbeing. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogen+deficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogen deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menopause%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menopause</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomized+mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomized mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+E%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin E</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palm+Oil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palm Oil</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tocotrienols%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tocotrienols/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22alpha-Tocopherol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">alpha-Tocopherol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menopause%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menopause/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Oils%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Oils/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mood+Disorders%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mood Disorders/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corticosterone%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corticosterone/blood</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Chen Z</b>, Jiang M, Mo L, Zhou C, Huang H, Ma C, Wang Z, Fan Y, Chen Z, Fang B, Liu Y. A natural agent, 5-deoxycajanin, mitigates estrogen-deficiency bone loss via modulating osteoclast-osteoblast homeostasis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>141</b>:112906. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39173403' target='_blank'>39173403</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.112906' target='_blank'>10.1016/j.intimp.2024.112906</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.112906','39173403', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.112906' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.intimp.2024.112906" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Hyperactive osteoclasts and hypoactive osteoblasts usually result in osteolytic conditions such as estrogen-deficiency bone loss. Few natural compounds that both attenuating bone resorption and enhancing bone formation could exert effects on this imbalance. 5-Deoxycajanin (5-D), an isoflavonoid extracted from Cajan leaf with estrogen-like properties, were found to have beneficial pharmacological effects on rebalancing the activities of osteoclasts and osteoblasts. This study revealed that 5-D at the same concentration could inhibit osteoclastogenesis of BMMs and promoted osteoblast differentiation of BMSCs. 5-D not only attenuated the fluorescent formation of RANKL-induced F-actin belts and NFATc1, but also activated ALP and RUNX2 expressions. As to downstream factor expressions, 5-D could block osteoclast-specific genes and proteins including NFATc1 and CTSK, while increased osteogenic genes and proteins including OPG and OCN, as confirmed by Real-time PCR and Western Blotting. Additionally, the network pharmacology and molecular docking identified the involvement of 5-D in the MIF and MAPK signaling pathways and the stable binding between 5-D and MAPK2K1. Further Western blot studies showed that 5-D decreased the phosphorylation of p38 and ERK in osteoclasts, but promoted these phosphorylations in osteoblasts. In a female C57BL/6J mouse model of estrogen deficiency-induced bone loss, 5-D demonstrated efficacy in enhancing BMD through attenuating osteoclast activities and promoting osteogenesis. These results underscore the potential application of 5-D on treating osteolysis resulting from hyperactive osteoclasts and hypoactive osteoblasts, shedding light on modulating osteoclast-osteoblast homeostasis. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%225-Deoxycajanin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">5-Deoxycajanin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+loss%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone loss</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fdeficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Resorption%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Resorption/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RANK+Ligand%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RANK Ligand/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Liu X</b>, Liu S, Sun H, Zhang J, Li M, Shi Y, Wang G, Chen W, Cao Y, Lu G, Ning Y, Zhao Y. NVP-BHG712 alleviates <span class="highlight-field">ovariectomy</span>-induced osteoporosis by modulating osteoclastogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2024;<b>983</b>:177000. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39278311' target='_blank'>39278311</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2024.177000' target='_blank'>10.1016/j.ejphar.2024.177000</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2024.177000','39278311', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ejphar.2024.177000' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.ejphar.2024.177000" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Postmenopausal osteoporosis (PMOP) is closely related to the pathogenesis of osteoclasts, with the Cathepsin K (CTSK) protein playing a crucial role. Our study aimed to screen small molecule compounds targeting CTSK and evaluate their impact on PMOP. Through molecular docking, we identified NVP-BHG712 as significantly inhibiting osteoclast differentiation and bone resorption. NVP-BHG712 also effectively suppressed CTSK activity and exhibited strong binding affinity to CTSK protein. Furthermore, NVP-BHG712 regulated the expression of inflammatory factors and modulated the balance between M1 and M2 macrophage polarization. In the mouse model of ovariectomy-induced osteoporosis, NVP-BHG712 rescued bone loss by inhibiting excessive osteoclast activation. These findings suggest that NVP-BHG712 may be a promising treatment for pathological osteoporosis by alleviating osteoclast function. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cathepsin+K%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cathepsin K</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NVP-BHG712%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NVP-BHG712</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclast+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclast differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoclasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoclasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cathepsin+K%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cathepsin K/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cathepsin+K%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cathepsin K/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Resorption%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Resorption/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Resorption%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Resorption/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Dai R</b>, Xu W, Zhu X, Sun R, Cheng L, Cui L, Qiu X, Wang Y, Sun Y. Acupuncture improves neuroendocrine defects in a preclinical rat model of reproductive aging. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2024;<b>357</b>:123102. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366551' target='_blank'>39366551</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2024.123102' target='_blank'>10.1016/j.lfs.2024.123102</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2024.123102','39366551', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.lfs.2024.123102' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.lfs.2024.123102" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">Clinical data supports electroacupuncture (EA) as an effective treatment for female reproductive disorders especially gonadotropin abnormalities. This study aims to detect the mechanism of EA that improves the neuroendocrine defects particularly the luteinizing hormone (LH) surge failure in early reproductive aging females. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Middle-aged ovariectomized rats primed with hormone were treated by EA at acupoints CV4 and SP6 and undergone LH assay. Morphological experiments detected the activation of Kiss1 cells in the anteroventral periventricular nucleus (AVPV). Using targeted liquid chromatography with tandem mass spectrometry (LC-MS/MS) and RNA-sequencing, we determined the concentrations of neurotransmitter metabolites and transcriptomics in AVPV. </div><div class="abstract-label">KEY FINDINGS</div><div class="abstract-content">EA significantly increased c-Fos and c-Fos-positive Kiss1 cells in the middle-aged AVPV as well as the total and peak LH release. Targeted LC-MS/MS and RNA-sequencing of AVPV identified differential neurotransmitters in the middle-aged females including Acetylcholine chloride, 5-Hydroxyindole-3-aceticacid, Kynurenine, Histamine, L-Histidine and L-Glycine, while EA decreased the concentration of Acetylcholine chloride. Totally 1255 differentially expressed genes modulated by EA were strongly implicated in neurotransmitter transport and KEGG pathways involved neuroactive ligand-receptor interaction, glutamatergic and gamma-aminobutyric acid-mediated synapse. Specifically, the mRNAs associated with the LH surge such as hormone receptor Pgr, adrenoceptor Adra1a, neurotransmitter transporters Slc17a6 and Slc32a1, glutamate decarboxylase Gad2 and Kiss1 were markedly altered by EA. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">These findings showed that the age-related reduction of LH surge occurred via differential neurotransmitter metabolisms and altered transcriptions in AVPV, which proposed EA-based therapy for improving responsiveness of the hypothalamus to hormone in women with advanced age. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luteinizing+hormone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luteinizing hormone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolism</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reproduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reproduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luteinizing+Hormone%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luteinizing Hormone/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kisspeptins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kisspeptins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroacupuncture%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroacupuncture/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurosecretory+Systems%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurosecretory Systems/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acupuncture+Therapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acupuncture Therapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurotransmitter+Agents%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurotransmitter Agents/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Ripolin A</b>, Volpe-Zanutto F, Sabri AH, Dos Santos VAB, Figueroba SR, Bezerra AAC, Vinicius Rodrigues Louredo B, Agustin Vargas P, McGuckin MB, Hutton ARJ, Larrañeta E, Franz-Montan M, Donnelly RF. Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11764);'>Int J Pharm</em> 2024;<b>665</b>:124642. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39208953' target='_blank'>39208953</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijpharm.2024.124642' target='_blank'>10.1016/j.ijpharm.2024.124642</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijpharm.2024.124642','39208953', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijpharm.2024.124642' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11764);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.ijpharm.2024.124642" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by facilitating the transdermal delivery of BPs. This study examines the delivery of alendronic acid (ALN) and risedronate sodium (RDN) using dissolving and hydrogel-forming MAPs for osteoporosis treatment. In vivo testing on osteoporotic female Sprague Dawley rats demonstrated the efficacy of MAPs, showing significant improvements in mean serum and bone alkaline phosphatase levels, bone volume, and porosity compared to untreated bilateral ovariectomy (OVX) controls. Specifically, MAP treatment increased mean bone volume to 55.04 ± 2.25 % versus 47.16 ± 1.71 % in OVX controls and reduced porosity to 44.30 ± 2.97 % versus 52.84 ± 1.70 % in the distal epiphysis of the femur. In the distal metaphysis, bone volume increased to 43.32 ± 3.24 % in MAP-treated rats compared to 24.31 ± 3.21 % in OVX controls, while porosity decreased to 55.39 ± 5.81 % versus 75.69 ± 3.21 % in OVX controls. This proof-of-concept study indicates that MAP technology has the potential to be a novel, patient-friendly alternative for weekly osteoporosis management. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dissolving+microarray+patches%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dissolving microarray patches</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogel-forming+microarray+patches%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogel-forming microarray patches</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risedronate+sodium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risedronate sodium</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transdermal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transdermal</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Cutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Cutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density+Conservation+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density Conservation Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronate%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronate/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alendronate%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alendronate/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risedronic+Acid%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risedronic Acid/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transdermal+Patch%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transdermal Patch</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diphosphonates%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diphosphonates/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diphosphonates%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diphosphonates/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diphosphonates%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diphosphonates/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alkaline+Phosphatase%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alkaline Phosphatase/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porosity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porosity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Solubility%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Solubility</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>柳鑫</b>, 石博, 蔡成, 王昊, 贾鹏. [Role of R-spondin 2 on osteogenic differentiation of bone marrow mesenchymal stem cells and bone metabolism in ovariectomized mice]. <em>ZHONGGUO XIU FU CHONG JIAN WAI KE ZA ZHI = ZHONGGUO XIUFU CHONGJIAN WAIKE ZAZHI = CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY</em> 2024;<b>38</b>:1399-1407. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39542634' target='_blank'>39542634</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563750' target='_blank'>PMC11563750</a> DOI: <a href='https://dx.doi.org/10.7507/1002-1892.202406083' target='_blank'>10.7507/1002-1892.202406083</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7507/1002-1892.202406083','39542634', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.7507/1002-1892.202406083" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Objective</div><div class="abstract-content">To investigate the effects of R-spondin 2 (Rspo2) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and bone mineral content in ovariectomized mice. </div><div class="abstract-label">Methods</div><div class="abstract-content">BMSCs were extracted from the bone marrow of the long bones of 7 4-week-old female C57BL/6 mice using whole bone marrow culture and passaged. After the cell phenotype was identified by flow cytometry, the 3rd generation cells were co-cultured with 10, 20, 40, 80, and 100 nmol/L Rspo2. Then, the cell activity and proliferative capacity were determined by cell counting kit 8 (CCK-8), and the intervention concentration of Rspo2 was screened for the subsequent experiments. The osteogenic differentiation ability of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA levels of osteogenesis-related genes [RUNX family transcription factor 2 (Runx2), collagen type Ⅰ alpha 1 (Col1), osteocalcin (OCN)] were detected by real-time fluorescence quantitative PCR (RT-qPCR). In addition, 18 10-week-old female C57BL/6 mice were randomly divided into sham operation group (sham group), ovariectomy group (OVX group), and OVX+Rspo2-intervention group (OVX+Rspo2 group), with 6 mice in each group. The sham group only underwent bilateral back incision and suturing, while the other two groups established osteoporosis mouse models by bilateral ovarian castration. Then, the mice were given a weekly intraperitoneal Rspo2 (1 mg/kg) treatment in OVX+Rspo2 group and saline at the same dosage in sham group and OVX group. After 12 weeks of treatment, the body mass and uterus mass of the mice were weighed in the 3 groups to assess whether the OVX model was successfully prepared; the tibia bones were stained with HE and immunohistochemistry staining to observe the changes in tibial bone mass and the expression level of Runx2 protein in the bone tissues. Blood was collected to detect the expressions of bone metabolism markers [ALP, OCN, type Ⅰ procollagen amino-terminal peptide (PINP)] and bone resorption marker [β-collagen degradation product (β-CTX)] by ELISA assay. Micro-CT was used to detect the bone microstructure changes in the tibia, and three-dimensional histomorphometric analyses were performed to analyze the trabeculae thickness (Tb.Th), trabeculae number (Tb.N), trabeculae separation (Tb.Sp), and bone volume fraction (BV/TV). </div><div class="abstract-label">Results</div><div class="abstract-content">CCK-8 assay showed that Rspo2 concentrations below 80 nmol/L were not cytotoxic ( P>0.05), and the cell viability of 20 nmol/L Rspo2 group was significantly higher than that of the control group ( P<0.05). Based on the above results, 10, 20, and 40 nmol/L Rspo2 were selected for subsequent experiments. ALP staining showed that the positive cell area of each concentration of Rspo2 group was significantly larger than that of the control group ( P<0.05), with the highest showed in the 20 nmol/L Rspo2 group. The expression levels of the osteogenesis-related genes (Runx2, Col1, OCN) significantly increased, and the differences were significant between Rspo2 groups and control group ( P<0.05) except for Runx2 in the 40 nmol/L Rspo2 group. In animal experiments, all groups of mice survived until the completion of the experiment, and the results of the body mass and uterus mass after 12 weeks of treatment showed that the OVX model was successfully prepared. Histological and immunohistochemical staining showed that the sparseness and connectivity of bone trabecula and the expression of Runx2 in the OVX group were lower than those in the sham group, whereas they were reversed in the OVX+Rspo2 group after treatment with Rspo2, and the differences were significant ( P<0.05). ELISA assay showed that compared with the sham group, the serum bone metabolism markers in OVX group had an increase in ALP and a decrease in PINP ( P<0.05). After Rspo2 intervention, PINP expression significantly reversed and increased, with significant differences compared to the sham group and OVX group ( P<0.05). The bone resorption marker (β-CTX) was significantly higher in the OVX group than in the sham group ( P<0.05), and it was significantly decreased in the OVX+Rspo2 group when compared with the OVX group ( P<0.05). Compared with the sham group, Tb.Th, Tb.N, and BV/TV significantly decreased in the OVX group, while Tb.Sp significantly increased ( P<0.05); after Rspo2 intervention, all of the above indexes significantly improved in the OVX+Rspo2 group ( P<0.05) except Tb.Th. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Rspo2 promotes differentiation of BMSCs to osteoblasts, ameliorates osteoporosis due to estrogen deficiency, and promotes bone formation in mice. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22R-spondin+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R-spondin 2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+formation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone formation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bone+marrow+mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bone marrow mesenchymal stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mouse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mouse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thrombospondins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thrombospondins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Marrow+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Marrow Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Marrow+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Marrow Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Density%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Density</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intercellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intercellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coculture+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coculture Techniques</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Xu J</b>, Huang Z, Shi S, Xia J, Chen G, Zhou K, Zhang Y, Bian C, Shen Y, Yin X, Lu L, Gu H. Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(4705);'>Cell Death Dis</em> 2024;<b>15</b>:829. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39543090' target='_blank'>39543090</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564563' target='_blank'>PMC11564563</a> DOI: <a href='https://dx.doi.org/10.1038/s41419-024-07234-z' target='_blank'>10.1038/s41419-024-07234-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41419-024-07234-z','39543090', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41419-024-07234-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4705);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1038/s41419-024-07234-z" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered the basic pathogenesis of osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in the differentiation of BMSCs, the role of actin cytoskeleton remodelling in the adipogenesis of BMSCs and postmenopausal osteoporosis (PMOP) has remained elusive. Glia maturation factor-beta (GMFB) has a unique role in remodelling the polymerization/depolymerization cycles of actin. We observed that GMFB expression was increased in bone tissue from both ovariectomized (OVX) rats and PMOP patients. GMFB knockout inhibited the accumulation of bone marrow adipocytes and increased bone mass in the OVX rat model. The inhibition of adipocyte differentiation in GMFB knockout BMSCs was mediated via actin cytoskeleton remodelling and the Ca2+-calcineurin-NFATc2 axis. Furthermore, we found that GMFB shRNA treatment in vivo had favourable effects on osteoporosis induced by OVX. Together, these findings suggest a pathological association of the GMFB with PMOP and highlight the potential of the GMFB as a therapeutic target for osteoporosis patients. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoporosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoporosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mesenchymal stem cells</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fdeficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estrogens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estrogens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Actins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Actins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glia+Maturation+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glia Maturation Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glia+Maturation+Factor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glia Maturation Factor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2c+Postmenopausal%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis, Postmenopausal/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Marrow+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Marrow Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFATC+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFATC Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoporosis%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoporosis/prevention & control</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Shanghai+(Natural+Science+Foundation+of+Shanghai+Municipality)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">22ZR1454900 Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shanghai+Minhang+Science+and+Technology+Commission+(Science+and+Technology+Commission%2c+Shanghai+Minhang)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022MHZ091 Shanghai Minhang Science and Technology Commission (Science and Technology Commission, Shanghai Minhang)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Shanghai+Minhang+District+(2024MHZ075)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural Science Foundation of Shanghai Minhang District (2024MHZ075)</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Lei H</b>, Liu J, Deng J, Zou P, Zou Z, Li Z, Li H, Luo L, Tan Z. Behavior, hormone, and gut microbiota change by YYNS intervention in an OVX mouse model. <em class='incite-journal-name' onclick='ShowInCiteJournal(9338);'>Front Cell Infect Microbiol</em> 2024;<b>14</b>:1445741. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39575307' target='_blank'>39575307</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580528' target='_blank'>PMC11580528</a> DOI: <a href='https://dx.doi.org/10.3389/fcimb.2024.1445741' target='_blank'>10.3389/fcimb.2024.1445741</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fcimb.2024.1445741','39575307', 'Ovariectomy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fcimb.2024.1445741' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fcimb.2024.1445741');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9338);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.3389/fcimb.2024.1445741" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Object</div><div class="abstract-content">Perimenopause depression disorder (PDD) is a very common problem in clinical practice and is characterized by depression and autonomic nervous symptoms, including hot flashes, palpitation, and night sweating. In addition, the comorbidity of menopause depression has long been an integral component of the estradiol (E2) shortage. Previous studies have suggested that the mechanisms underlying this comorbidity involved overlap of endocrine and cerebellar networks. Emerging evidence has shown that the endocrine-brain-gut-microbiota axis plays a key role in the regulation of affective disorders. Yangyin-ningshen formula (YYNS) is a traditional Chinese decoction tailored by Yijintang for menopausal depression intervention. Thus, we hypothesized that the YYNS may be involved in the menopause depression alleviation through the endocrine-brain-gut-microbiota axis. </div><div class="abstract-label">Methods</div><div class="abstract-content">To verify this, we constructed a bilateral ovariectomy (OVX) mouse model to simulate menopausal-related depression. Subsequently, behavioral tests including the open field test (OFT) and the forced swimming test (FST) were conducted to examine the depression state post-OVX. With YYNS or E2 intervention, enzyme-linked immunosorbent assay (ELISA) was used to determine the serum sex hormones level. 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) were used to analyze the microbiome of the colon samples collected from mice in the sham surgery group (CSH), the OVX model group (CMD), the OVX with E2 hormone intervention group (CHM), and the OVX with YYNS intervention group (CYYNS). One week after OVX, CMD, CHM, and CYYNS showed depression in OFT, FST. Three weeks post-OVX, CHM and CYYNS showed a notable relief of depression; CMD shaped the OTUs shrinkage; and OTUs were raised in the sham, CHM, and CYYNS group. The CMD group showed that the abundance of Actinobiota decreased but that of Bacteriodia increased. The relative abundance of the genus varied in each group. Moreover, functional correlation of changes in sex hormone and gut microbes between different groups showed that the PRL level was negatively correlated with Odoribacter. T level was positively correlated with Lachnospiraceae NK4A136 group and Odoribacter abundance (p < 0.05). </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Our results not only offer novel insights into the sex hormones and depression with OVX mice but also build an important basis for E2 or YYNS therapeutic efficacy on PDD, which provide for future research on this etiology through the endocrine-brain-gut-microbiota network. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22E2-gut-brain+axis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">E2-gut-brain axis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OVX%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OVX</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yangyin-ningshen+formula%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yangyin-ningshen formula</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endocrine-brain-gut-microbiota+axis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endocrine-brain-gut-microbiota axis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gut+flora%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gut flora</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22premenopause+depression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">premenopause depression</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovariectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Ribosomal%2c+16S%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Ribosomal, 16S/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Estradiol%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Estradiol/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain-Gut+Axis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain-Gut Axis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gonadal+Steroid+Hormones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gonadal Steroid Hormones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gonadal+Steroid+Hormones%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gonadal Steroid Hormones/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menopause%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menopause</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/isolation & purification</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 661 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><b class="dxp-ellip" style="margin-left:0px;">…</b><a class="dxp-num page-number" href="/Search?page=660&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">660</a><a class="dxp-num page-number" href="/Search?page=661&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">661</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovariectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_652892274" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Ovariectomy (16507 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Ovariectomy (16507 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>