CINXE.COM

<!doctype html> <html lang="en-US"> <head> <meta charset="utf-8"> <meta http-equiv="x-ua-compatible" content="ie=edge"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <script> const tracking = null; </script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>Mucosal Covid Vax Trials Kicking Into High Gear (Update 20) - Absolutely Maybe</title> <link rel="canonical" href="https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Mucosal Covid Vax Trials Kicking Into High Gear (Update 20) - Absolutely Maybe" /> <meta property="og:description" content="Soon, tens of thousands volunteers will be needed for Covid vaccine trials in the US again. At least some of the “mini-efficacy&rdquo…" /> <meta property="og:url" content="https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/" /> <meta property="og:site_name" content="Absolutely Maybe" /> <meta property="article:published_time" content="2024-08-31T22:55:06+00:00" /> <meta property="article:modified_time" content="2024-11-25T14:47:21+00:00" /> <meta property="og:image" content="https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-scaled.jpg" /> <meta property="og:image:width" content="2560" /> <meta property="og:image:height" content="1975" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="author" content="Hilda Bastian" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Hilda Bastian" /> <meta name="twitter:label2" content="Est. reading time" /> <meta name="twitter:data2" content="19 minutes" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/","url":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/","name":"Mucosal Covid Vax Trials Kicking Into High Gear (Update 20) - Absolutely Maybe","isPartOf":{"@id":"https://absolutelymaybe.plos.org/#website"},"primaryImageOfPage":{"@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/#primaryimage"},"image":{"@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/#primaryimage"},"thumbnailUrl":"https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-scaled.jpg","datePublished":"2024-08-31T22:55:06+00:00","dateModified":"2024-11-25T14:47:21+00:00","author":{"@id":"https://absolutelymaybe.plos.org/#/schema/person/7ead2ccdf2bb9a70a992518d281bb491"},"breadcrumb":{"@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/#primaryimage","url":"https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-scaled.jpg","contentUrl":"https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-scaled.jpg","width":2560,"height":1975,"caption":"A man in a doctor's office tells a woman, \"Challenge accepted!\" (Cartoon by Hilda Bastian.)"},{"@type":"BreadcrumbList","@id":"https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://absolutelymaybe.plos.org/"},{"@type":"ListItem","position":2,"name":"Mucosal Covid Vax Trials Kicking Into High Gear (Update 20)"}]},{"@type":"WebSite","@id":"https://absolutelymaybe.plos.org/#website","url":"https://absolutelymaybe.plos.org/","name":"Absolutely Maybe","description":"Evidence and uncertainties about medicine, science culture, and life.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://absolutelymaybe.plos.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https://absolutelymaybe.plos.org/#/schema/person/7ead2ccdf2bb9a70a992518d281bb491","name":"Hilda Bastian","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://absolutelymaybe.plos.org/#/schema/person/image/5ec74066203fbd9041e6510d1ecc2742","url":"https://secure.gravatar.com/avatar/b7cccea0f2a6ef54318ec7ce197a438f?s=96&d=mm&r=g","contentUrl":"https://secure.gravatar.com/avatar/b7cccea0f2a6ef54318ec7ce197a438f?s=96&d=mm&r=g","caption":"Hilda Bastian"},"url":"https://absolutelymaybe.plos.org/author/hbastian/"}]}</script>  <link rel='dns-prefetch' href='//absolutelymaybe.plos.org' /> <link rel="alternate" type="application/rss+xml" title="Absolutely Maybe » Mucosal Covid Vax Trials Kicking Into High Gear (Update 20) Comments Feed" href="https://absolutelymaybe.plos.org/2024/08/31/mucosal-covid-vax-trials-kicking-into-high-gear-update-20/feed/" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/absolutelymaybe.plos.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://absolutelymaybe.plos.org/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='safe-svg-svg-icon-style-inline-css' type='text/css'> .safe-svg-cover{text-align:center}.safe-svg-cover .safe-svg-inside{display:inline-block;max-width:100%}.safe-svg-cover svg{height:100%;max-height:100%;max-width:100%;width:100%} </style> <style id='co-authors-plus-coauthors-style-inline-css' type='text/css'> .wp-block-co-authors-plus-coauthors.is-layout-flow [class*=wp-block-co-authors-plus]{display:inline} </style> <style id='co-authors-plus-avatar-style-inline-css' type='text/css'> .wp-block-co-authors-plus-avatar :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-avatar :where(img){vertical-align:middle}.wp-block-co-authors-plus-avatar:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-avatar.aligncenter{display:table;margin-inline:auto} </style> <style id='co-authors-plus-image-style-inline-css' type='text/css'> .wp-block-co-authors-plus-image{margin-bottom:0}.wp-block-co-authors-plus-image :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-image :where(img){vertical-align:middle}.wp-block-co-authors-plus-image:is(.alignfull,.alignwide) :where(img){width:100%}.wp-block-co-authors-plus-image:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-image.aligncenter{display:table;margin-inline:auto} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){margin-left: auto !important;margin-right: auto !important;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='prefix-style-css' href='https://absolutelymaybe.plos.org/wp-content/plugins/orcid-master/assets/orcid.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='sage/main.css-css' href='https://absolutelymaybe.plos.org/wp-content/themes/plos/dist/styles/main_2eafddd7.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-content/themes/plos/resources/lib/scripts/jquery-3.5.1.min.js?ver=3.5.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-content/plugins/orcid-master/assets/orcid.js?ver=6.6.2" id="orcid-javascript-js"></script> <link rel="https://api.w.org/" href="https://absolutelymaybe.plos.org/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://absolutelymaybe.plos.org/wp-json/wp/v2/posts/8502" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://absolutelymaybe.plos.org/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.6.2" /> <link rel='shortlink' href='https://absolutelymaybe.plos.org/?p=8502' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://absolutelymaybe.plos.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fabsolutelymaybe.plos.org%2F2024%2F08%2F31%2Fmucosal-covid-vax-trials-kicking-into-high-gear-update-20%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://absolutelymaybe.plos.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fabsolutelymaybe.plos.org%2F2024%2F08%2F31%2Fmucosal-covid-vax-trials-kicking-into-high-gear-update-20%2F&format=xml" /> <style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style> <link href="https://fonts.googleapis.com/css?family=Merriweather:400,400i,900,900i|Roboto:400,400i,600,600i&display=swap" rel="stylesheet"> <link rel="apple-touch-icon" sizes="180x180" href="https://plos.org/wp-content/themes/plos/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://plos.org/wp-content/themes/plos/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://plos.org/wp-content/themes/plos/favicon/favicon-16x16.png"> <link rel="manifest" href="https://plos.org/wp-content/themes/plos/favicon/site.webmanifest"> <link rel="mask-icon" href="https://plos.org/wp-content/themes/plos/favicon/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="https://plos.org/wp-content/themes/plos/favicon/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="https://plos.org/wp-content/themes/plos/favicon/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> <style type="text/css"> header.app-header, .archive__header, .search__header { background-color: #ffffff; color: #00156b; } header.app-header a, .app-header__search-container input[type=search].search-form__field, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--prev a, .archive__header li.pagination__item--next a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item--page a, .search__header li.pagination__item--prev a, .search__header li.pagination__item--next a, .search__header a.pagination__mobile-link { color: #00156b; } .app-header__drawer-small-title, .app-header__container:after, .app-header__drawer:after, .app-header__nav-toggle span, .app-header__nav-toggle span:before, .app-header__nav-toggle span:after, a.app-header__nav-toggle span, a.app-header__nav-toggle span:before, a.app-header__nav-toggle span:after, ul.app-header__primary-nav > li.menu-item-has-children > a:after, ul.app-header__primary-nav > li.menu-item-has-children:hover > a:after, .app-header__search-container .search-form__label:before, .app-header__search-container .search-form__label:after, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a, ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--page a:hover, .archive__header li.pagination__item--page a:focus, .search__header li.pagination__item--page a, .search__header li.pagination__item--page a:hover, .search__header li.pagination__item--page a:focus { border-color: #00156b; } ul.app-header__primary-nav > li.current-menu-item > a:before, ul.app-header__primary-nav > li.current-page-ancestor > a:before { border-color: #ffffff; } .app-header .button.button--shortcode.button--s, .search__header input[type=submit] { border-color: #00156b; background: #00156b; color: #ffffff; } .app-header .button.button--shortcode.button--s:hover, .app-header .button.button--shortcode.button--s:focus, .search__header input[type=submit]:hover, .search__header input[type=submit]:focus { background: #00156b; color: #ffffff; opacity: 0.85; } ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a { background-color: #ffffff; } .app-header__drawer a:not(.post-list__post-image), .archive__header li.pagination__item a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item a, .search__header a.pagination__mobile-link { background-image: linear-gradient(#00156b, #00156b); } .app-header__drawer a:not(.post-list__post-image):hover, .app-header__drawer a:not(.post-list__post-image):focus, .archive__header li.pagination__item a:hover, .archive__header li.pagination__item a:focus, .archive__header a.pagination__mobile-link:hover, .archive__header a.pagination__mobile-link:focus, .search__header li.pagination__item a:hover, .search__header li.pagination__item a:focus, .search__header a.pagination__mobile-link:hover, .search__header a.pagination__mobile-link:focus { color: #ffffff; background-size: 100% 100%; background-position: 0% 100%; } .archive__header li.pagination__item--page.pagination__item--current a, .search__header li.pagination__item--page.pagination__item--current a { background-color: #00156b; border-color: #00156b; color: #ffffff; } .search__header form.search-form input[type=search] { background-color: #ffffff; border-color: #00156b; color: #00156b; } </style>  <script> /*! For license information please see head.js.LICENSE.txt */ (()=>{var e={773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var o,r=(o=n(808))&&o.__esModule?o:{default:o},i=n(773);function u(e){return Object.assign({},...i.VALID_PURPOSES.map((t=>({[t]:e}))))}var a={get:function(){try{const e=JSON.parse(r.default.get(i.COOKIE_KEY));return e?!0===e?u(!0):e:u(!1)}catch(e){return u(!1)}},isSet:function(){return void 0!==r.default.get(i.COOKIE_KEY)},remove:function(){r.default.remove(i.COOKIE_KEY)},set:function(e){const t=window.location.hostname;r.default.set(i.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:i.RECONSENT_INTERVAL})}};t.default=a},177:(e,t,n)=>{"use strict";t.default=void 0;var o,r=(o=n(502))&&o.__esModule?o:{default:o},i=n(773);function u(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,r.default.get())}var a={accept:function(){r.default.set(!0),u()},customize:function(e,t){r.default.set(Object.assign(r.default.get(),{[e]:t})),u()},hasConsented:function(e){if(!i.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+i.VALID_PURPOSES.toString());return r.default.get()[e]},hasInteracted:function(){return r.default.isSet()},reject:function(){r.default.set(!1),u()},reset:function(){r.default.remove()},VALID_PURPOSES:i.VALID_PURPOSES};t.default=a},808:(e,t,n)=>{var o,r,i;void 0===(r="function"==typeof(o=i=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var o in n)t[o]=n[o]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(o){function r(){}function i(t,n,i){if("undefined"!=typeof document){"number"==typeof(i=e({path:"/"},r.defaults,i)).expires&&(i.expires=new Date(1*new Date+864e5*i.expires)),i.expires=i.expires?i.expires.toUTCString():"";try{var u=JSON.stringify(n);/^[\{\[]/.test(u)&&(n=u)}catch(e){}n=o.write?o.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var a="";for(var c in i)i[c]&&(a+="; "+c,!0!==i[c]&&(a+="="+i[c].split(";")[0]));return document.cookie=t+"="+n+a}}function u(e,n){if("undefined"!=typeof document){for(var r={},i=document.cookie?document.cookie.split("; "):[],u=0;u<i.length;u++){var a=i[u].split("="),c=a.slice(1).join("=");n||'"'!==c.charAt(0)||(c=c.slice(1,-1));try{var s=t(a[0]);if(c=(o.read||o)(c,s)||t(c),n)try{c=JSON.parse(c)}catch(e){}if(r[s]=c,e===s)break}catch(e){}}return e?r[e]:r}}return r.set=i,r.get=function(e){return u(e,!1)},r.getJSON=function(e){return u(e,!0)},r.remove=function(t,n){i(t,"",e(n,{expires:-1}))},r.defaults={},r.withConverter=n,r}((function(){}))})?o.call(t,n,t,e):o)||(e.exports=r),e.exports=i()}},t={};function n(o){var r=t[o];if(void 0!==r)return r.exports;var i=t[o]={exports:{}};return e[o](i,i.exports,n),i.exports}(()=>{"use strict";var e=n(177);window.plosCookieConsent=e.default})()})(); </script>  </head> <body class="post-template-default single single-post postid-8502 single-format-standard mucosal-covid-vax-trials-kicking-into-high-gear-update-20 app-data index-data singular-data single-data single-post-data single-post-mucosal-covid-vax-trials-kicking-into-high-gear-update-20-data elementor-default elementor-kit-2665"> <a class="skip-to-content" href="#content">Skip to content</a> <div id="top"></div> <header class="app-header"> <div class="app-header__container container"> <a class="app-header__brand" href=//plos.org> <img class="app-header__logo" src="https://absolutelymaybe.plos.org/wp-content/uploads/2020/01/logo-sea.svg" alt="Absolutely Maybe logo" /> </a> <nav class="app-header__nav"> <div class="app-header__nav-row"> <div class="app-header__primary-nav-container"> <div class="menu-header-navigation-container"><ul id="menu-header-navigation" class="app-header__primary-nav"><li id="menu-item-411" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-411"><a href="https://plos.org/publish/">Publish with PLOS</a> <ul class="sub-menu"> <li id="menu-item-9363" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9363"><a href="https://plos.org/your-journal-options/">Which Journal?</a></li> <li id="menu-item-1409" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1409"><a href="https://plos.org/publish/submit/">Submit</a></li> <li id="menu-item-2355" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2355"><a href="https://plos.org/publish/publishing-faqs/">Publishing FAQs</a></li> <li id="menu-item-2356" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2356"><a href="https://plos.org/publish/fees/">Fees</a></li> <li id="menu-item-2357" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2357"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-2358" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2358"><a href="https://plos.org/publish/metrics/">Metrics</a></li> <li id="menu-item-2359" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2359"><a href="https://plos.org/publish/funder-compliance/">Funder Compliance</a></li> <li id="menu-item-34242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34242"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> </ul> </li> <li id="menu-item-307" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-307"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-384" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-384"><a href="https://plos.org/open-science/">Open Science</a> <ul class="sub-menu"> <li id="menu-item-18582" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-18582"><a href="https://plos.org/open-science/open-access/">Open Access</a></li> <li id="menu-item-16399" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16399"><a href="https://plos.org/open-science/preprints/">Preprints</a></li> <li id="menu-item-17362" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17362"><a href="https://plos.org/open-science/open-data/">Open Data</a></li> <li id="menu-item-9918" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9918"><a href="https://plos.org/open-science/open-methods/">Open Methods</a></li> <li id="menu-item-7116" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7116"><a href="https://plos.org/protocols/">Protocols</a></li> <li id="menu-item-17916" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17916"><a href="https://plos.org/open-science/preregistration/">Preregistration</a></li> <li id="menu-item-17327" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-17327"><a href="https://plos.org/open-science/open-code/">Open Code</a></li> <li id="menu-item-2361" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2361"><a href="https://plos.org/published-peer-review-history/">Published Peer Review History</a></li> <li id="menu-item-16833" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16833"><a href="https://plos.org/open-science/credit/">Credit</a></li> </ul> </li> <li id="menu-item-260" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-260"><a href="https://plos.org/resources/">Resources</a> <ul class="sub-menu"> <li id="menu-item-692" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-692"><a href="https://plos.org/resources/for-institutions/">For Institutions</a></li> <li id="menu-item-5291" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5291"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-8642" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8642"><a href="https://plos.org/resources/editor-center/">Editor Center</a></li> <li id="menu-item-425" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-425"><a href="https://plos.org/resources/for-reviewers/">Peer Review Center</a></li> <li id="menu-item-16410" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16410"><a href="https://plos.org/research-by-plos/">Research by PLOS</a></li> <li id="menu-item-5004" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5004"><a href="https://plos.org/resources/writing-center/">Writing Center</a></li> </ul> </li> <li id="menu-item-420" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-420"><a href="https://plos.org/about/">About PLOS</a></li> </ul></div> </div> <div class="app-header__nav-controls"> <div class="app-header__search-container"> <form role="search" method="get" class="search-form" action="//plos.org"> <label class="search-form__label" for="s"><span class="screen-reader-text">Search:</span></label> <input type="search" class="search-form__field" value="" name="s" id="s" /> <input type="submit" class="search-form__submit" value="Search" /> </form> </div> <a class="app-header__nav-toggle" href="#"><span>Menu</span></a> </div> </div> </nav> </div> <div class="app-header__drawer"> <div class="app-header__drawer-container"> <div class="app-header__drawer-col app-header__drawer-content"> <div class="app-header__drawer-rich-text"> <p><span style="font-weight: 400;">When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.</span></p> <div class="acf-label"> <p class="description"></p> </div> </div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">Journals</span> <div class="menu-journals-container"><ul id="menu-journals" class="app-header__drawer-menu app-header__drawer-menu--1"><li id="menu-item-275" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-275"><a href="https://journals.plos.org/plosbiology/">PLOS Biology</a></li> <li id="menu-item-8531" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8531"><a href="https://journals.plos.org/climate">PLOS Climate</a></li> <li id="menu-item-31915" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31915"><a href="https://journals.plos.org/complexsystems/">PLOS Complex Systems</a></li> <li id="menu-item-276" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-276"><a href="https://journals.plos.org/ploscompbiol/">PLOS Computational Biology</a></li> <li id="menu-item-8535" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8535"><a href="https://journals.plos.org/digitalhealth">PLOS Digital Health</a></li> <li id="menu-item-277" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-277"><a href="https://journals.plos.org/plosgenetics/">PLOS Genetics</a></li> <li id="menu-item-8534" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8534"><a href="https://journals.plos.org/globalpublichealth">PLOS Global Public Health</a></li> <li id="menu-item-278" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-278"><a href="https://journals.plos.org/plosmedicine/">PLOS Medicine</a></li> <li id="menu-item-31916" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31916"><a href="https://journals.plos.org/mentalhealth/">PLOS Mental Health</a></li> <li id="menu-item-279" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-279"><a href="https://journals.plos.org/plosntds/">PLOS Neglected Tropical Diseases</a></li> <li id="menu-item-280" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-280"><a href="https://journals.plos.org/plosone/">PLOS ONE</a></li> <li id="menu-item-281" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-281"><a href="https://journals.plos.org/plospathogens/">PLOS Pathogens</a></li> <li id="menu-item-8533" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8533"><a href="https://journals.plos.org/sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li id="menu-item-8532" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8532"><a href="https://journals.plos.org/water">PLOS Water</a></li> </ul></div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">More Content</span> <div class="menu-more-content-container"><ul id="menu-more-content" class="app-header__drawer-menu app-header__drawer-menu--2"><li id="menu-item-282" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-282"><a href="https://plos.org/blogs/">PLOS Blogs</a></li> <li id="menu-item-283" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-283"><a href="https://collections.plos.org/">PLOS Collections</a></li> </ul></div> </div> </div> </div> </header> <style>.blog-header__background { background-image: url(https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2020/05/Absolutely-Maybe-2020_3.jpg); }.blog-header__text { color: #ffffff }.blog-header__author-orcid { color: #ffffff }.blog-header__orcid-icon { background-color: #ffffff }</style><div class="blog-header"> <div class="blog-header__text"> <span class="blog-header__label">PLOS BLOGS</span> <a class="blog-header__blog-name" href="https://absolutelymaybe.plos.org">Absolutely Maybe</a> <div class="blog-header__background"></div> </div> <div class="blog-header__blogs-navigation blogs-navigation"> <div class="blogs-navigation__container"> <a class="blogs-navigation__mobile-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__mobile-container"> <div class="blogs-navigation__main-menu-container"> <div class="menu-blog-navigation-container"><ul id="menu-blog-navigation" class="blogs-navigation__main-menu"><li id="menu-item-1876" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1876"><a href="https://absolutelymaybe.plos.org/about-hilda-bastian/">About This Blog</a></li> </ul></div> </div> <div class="blogs-navigation__drawer"> <a class="blogs-navigation__drawer-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__drawer-menu-container"> <div class="menu-blogs-menu-container"><ul id="menu-blogs-menu" class="blogs-navigation__drawer-menu"><li id="menu-item-3654" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3654"><a href="#">Staff Blogs</a> <ul class="sub-menu"> <li id="menu-item-3655" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3655"><a href="https://theplosblog.plos.org">Official PLOS Blog</a></li> <li id="menu-item-3656" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3656"><a href="http://everyone.plos.org">EveryONE Blog</a></li> <li id="menu-item-9185" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9185"><a href="https://latitude.plos.org/">Latitude</a></li> <li id="menu-item-3657" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3657"><a href="https://speakingofmedicine.plos.org">Speaking of Medicine</a></li> <li id="menu-item-3658" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3658"><a href="https://biologue.plos.org">PLOS Biologue</a></li> <li id="menu-item-3659" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3659"><a href="https://collectionsblog.plos.org/">PLOS Collections</a></li> </ul> </li> <li id="menu-item-3660" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3660"><a href="#">Independent Blogs</a> <ul class="sub-menu"> <li id="menu-item-3661" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3661"><a href="https://absolutelymaybe.plos.org">Absolutely Maybe</a></li> <li id="menu-item-3662" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3662"><a href="https://dnascience.plos.org">DNA Science</a></li> <li id="menu-item-3663" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3663"><a href="https://ecrcommunity.plos.org">PLOS ECR Community</a></li> <li id="menu-item-3664" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3664"><a href="https://scicomm.plos.org">SciComm</a></li> <li id="menu-item-3665" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3665"><a href="https://allmodels.plos.org">All Models Are Wrong</a></li> <li id="menu-item-3896" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3896"><a href="https://yoursay.plos.org">Your Say</a></li> </ul> </li> <li id="menu-item-3666" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3666"><a href="#">About</a> <ul class="sub-menu"> <li id="menu-item-3821" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3821"><a href="https://plos.org/blogs/about/">About PLOS Blogs</a></li> <li id="menu-item-3820" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3820"><a href="https://plos.org/blogs/contact/">Contact</a></li> </ul> </li> </ul></div> </div> </div> </div> </div> </div> </div> <div class="wrap" role="document"> <div class="content" id="content"> <main class="main"> <article class="single-article post-8502 post type-post status-publish format-standard has-post-thumbnail hentry category-covid-19 tag-covid-19-vaccine-race"> <header class="single-header"> <h1 class="single-header__title">Mucosal Covid Vax Trials Kicking Into High Gear (Update 20)</h1> <div class="single-header__meta"> <time class="single-header__post-date" datetime="2024-08-31T22:55:06+00:00">August 31, 2024</time> <span class="single-header__post-author"> <a href="https://absolutelymaybe.plos.org/author/hbastian/">Hilda Bastian</a> </span> <span class="single-header__post-categories"> <a class="single-header__post-category single-header__post-category--covid-19" href="https://absolutelymaybe.plos.org?category=covid-19">Covid-19</a> </span> </div> </header> <div class="single-content"> <figure class="wp-block-image size-large is-resized"><img decoding="async" width="1024" height="790" src="https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-1024x790.jpg" alt="A man in a doctor's office tells a woman, "Challenge accepted!" (Cartoon by Hilda Bastian.)" class="wp-image-8506" style="width:351px;height:auto" srcset="https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-1024x790.jpg 1024w, https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-300x231.jpg 300w, https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-768x592.jpg 768w, https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-1536x1185.jpg 1536w, https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/08/Challenge-accepted-2048x1580.jpg 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <div style="height:23px" aria-hidden="true" class="wp-block-spacer"></div> <p>Soon, tens of thousands volunteers will be needed for Covid vaccine trials in the US again. At least some of the “mini-efficacy” trials funded by Project NextGen will be kicking off soon. And this month, we got our first look at some key details of how they will work – for a mucosal vaccine that appears likely to be the first cab off a rank. Meanwhile, volunteers for a human challenge trial are being recruited in the UK.</p> <p>In other news, there is a bit of new clinical trial data for a mucosal vaccine – and another one is heading for its phase 1, first-in-human, trial. And I’ve added 10 preclinical study results to my collection this month.</p> <p>This update starts with news on the human challenge trial in the UK. After that, as usual I have the news from the last month broken down into 3 categories of next-generation Covid vaccines (<a href="#definitions">definitions below</a>). Each of these sections ends with an overview of vaccines in the category.</p> <h2 class="wp-block-heading" id="contents"></h2> <ul class="wp-block-list"> <li>News on <a href="#challenge">human challenge trials</a></li> <li><a href="#mucosal">Mucosal</a> vaccine news</li> <li>Durable or <a href="#panSARS2">“variant-proof”</a> vaccine news</li> <li><a href="#pancoronavirus">Pancoronavirus</a> vaccine news</li> <li><em>Addendum 1: </em>List of <a href="#authorizations">authorized</a> vaccines (with countries)</li> <li><em>Addendum 2:</em> Table of <a href="#mucosaltable">mucosal vaccines</a> in clinical trials</li> <li><em>Addendum 3: </em>Table of <a href="#pantable">pancoronavirus vaccines</a> with results</li> <li><em>Addendum 4:</em> <a href="#definitions">Definitions</a> of vaccine types</li> </ul> <h2 class="wp-block-heading" id="challenge"></h2> <div style="height:31px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading" id="nextgen">News on human challenge trials</h4> <div style="height:21px" aria-hidden="true" class="wp-block-spacer"></div> <p>The MUSiCC Project is moving fast. Funding for this international program led by Imperial College London was only announced a few months ago. (I wrote about that <a href="https://absolutelymaybe.plos.org/2024/03/29/a-huge-boost-for-mucosal-covid-vax-development-next-generation-update-15/#nextgen">here</a>.) The project aims to dramatically speed up the development of mucosal vaccines for Covid. Human challenge studies involve trying to infect volunteers under controlled conditions. That way, you can find out very quickly, with very few participants, whether or not a vaccine protects people from infection. (If you’re concerned about the risks of this, I wrote my thoughts on that <a href="https://hildabastian.wordpress.com/2024/04/09/the-risks-we-take-for-others/">here</a>.)</p> <p>The first step is deciding which Covid variant to use, and then developing a version that is infectious enough to work for a trial, with the lowest risks. Now that people are vaccinated against Covid, this is a very tough job. The team is already running a trial on their try at this – recruiting people in Oxford and London.</p> <p>The trial is called COV-CHIM2, and there’s a lot of detail about it in the <a href="https://www.jenner.ac.uk/volunteer/recruiting-trials/cov-chim02">information for prospective participants</a> that’s now online. They are testing a version of Omicron BA.5. The first step will need about 21 volunteers to find the best dose of the infection. The next step will be to confirm the dose and test safety in 24 volunteers. They plan to finish by the end of this year.</p> <p>For participants, this is expected to be a 2-week commitment. People will be quarantined in a special unit in Oxford. If they get sick and develop serious symptoms, they will get Paxlovid and any other care they need. Only people who are at very low risk of getting seriously ill are eligible for the trial, though, so the chances of one of that small group getting very sick is very low.</p> <p>No word yet on which vaccines will go into human challenge trials once they have a successful version. Vaccine developers had <a href="https://www.musicc.org/">up to August 23 to indicate their interest</a> in participating.</p> <p><a href="https://investors.vaxart.com/news-releases/news-release-details/vaxart-announces-agreement-hvivo-develop-worlds-first-human">Back in 2022</a>, Vaxart was planning on participating in a human challenge study in the UK, but I haven’t seen if they are still interested. (They have done studies like this <a href="https://investors.vaxart.com/static-files/eb9fdda7-9db1-4dad-93ee-c95d943c46ba">for their norovirus and influenza vaccines</a>.) More on their oral Covid vaccine in the next section.</p> <div style="height:14px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="https://absolutelymaybe.plos.org/wp-admin/post.php?post=8040&action=edit#contents">Back to contents</a></em></p> <div style="height:34px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" id="mucosal"></h2> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading">Mucosal vaccine news</h4> <div style="height:22px" aria-hidden="true" class="wp-block-spacer"></div> <p>This month, there are 3 pieces of clinical trial news:</p> <ul class="wp-block-list"> <li>Some details of the phase 2b “mini-efficacy” trial for the oral viral vector vaccine from Vaxart in the US;</li> </ul> <ul class="wp-block-list"> <li>Additional brief details from Vaxart’s earlier trials; and</li> </ul> <ul class="wp-block-list"> <li>An intranasal vaccine developed at an Australian university is heading into a clinical trial with an Indian pharmaceutical company.</li> </ul> <p>And in case you missed it, a few months ago <a href="https://hildabastian.wordpress.com/2024/05/07/when-will-we-get-a-sterilizing-covid-vaccine/">I wrote a post</a> to a question I get a lot: “When Will We Get a Sterilizing Covid Vaccine?”</p> <p><em>Project NextGen-funded Phase 2b trial details (Vaxart):</em></p> <p>All of these trials are to be for 10,000 participants, with half randomized to the mucosal vaccine and the other half to an mRNA vaccine. Vaxart has reported the earliest start plans I’ve seen so far. In a <a href="https://investors.vaxart.com/news-releases/news-release-details/vaxart-announces-positive-top-line-phase-ii-clinical-study-data">presentation to investors</a>, the company released additional details about the trial:</p> <ul class="wp-block-list"> <li>The vaccine will be a version adapted for Omicron XBB;</li> </ul> <ul class="wp-block-list"> <li>The primary endpoint will be prevention of symptomatic disease at 12 months;</li> </ul> <ul class="wp-block-list"> <li>Interim analysis for vaccine efficacy is set for when 255 participants have symptomatic disease.</li> </ul> <p>Depending on FDA approval for their plans, they still expect to start recruiting this year.</p> <p><em>Vaxart clinical trial data:</em></p> <p>Vaxart released a preprint for results for the 35 participants in their phase 1 trial <a href="https://www.medrxiv.org/content/10.1101/2022.07.16.22277601v1">in 2022</a>. In the <a href="https://investors.vaxart.com/static-files/eb9fdda7-9db1-4dad-93ee-c95d943c46ba">same presentation</a> to investors, there are a few more details. The developers tested participants for signs of intranasal immune response to a range of coronaviruses. In the preprint, they had reported some immune response to the original SARS. Now, they report that “46% of participants that had increased IgA antibodies to SARS-CoV-2 S also had increased antibody responses to the S protein of other coronaviruses, including SARS-CoV-1, MERS, and endemic common cold viruses.”</p> <p>They also report some results for 20 participants from their phase 2 trial, which adds a little to the data the company included in a <a href="https://investors.vaxart.com/news-releases/news-release-details/vaxart-announces-positive-top-line-phase-ii-clinical-study-data">press release in 2022</a>. This new data is for a group of participants who had previously had an mRNA vaccine, and report that 7 of the 20 gained additional protection against Omicron after the Vaxart booster.</p> <p><em>CDO-7N-1, a live attenuated vaccine developed by Griffith University, heading to clinical trial:</em></p> <p>The developers published <a href="https://www.nature.com/articles/s41467-024-51535-y">preclinical results</a> for this single-dose intranasal vaccine, tested in mice, hamsters, and macaques. They report signs of immune response for Covid, including Beta, Delta, and Omicron XBB.1.5 variants, and the original SARS.</p> <p>In <a href="https://news.griffith.edu.au/2024/08/27/game-changing-needle-free-covid-19-intranasal-vaccine/">a press release</a>, the developers reported that they have licensed the vaccine to Indian Immunologicals Ltd, who plan to take it into clinical trial.</p> <p><em>More new preclinical results:</em></p> <p>As well as the one for CDO-7N-1, I have added another 2 preclinical reports for mucosal vaccines to my collection since the last update:</p> <ul class="wp-block-list"> <li><em>ChAd-SARS CoV-2-S</em> <em>from Washington University St Louis (USA):</em> This intranasal viral vector vaccine is the vaccine developed and used in India by Bharat Biotech (called iNCOVACC). <a href="https://www.science.org/doi/10.1126/sciadv.adp1290">A transmission study</a> was undertaken in hamsters. They were vaccinated either with the intranasal vaccine, or injected with an mRNA vaccine, and then infected with Covid in a challenge test. To mimic common exposure, unvaccinated hamsters were exposed to the infected vaccinated ones for 8 hours, on 2 occasions. The intranasal vaccine prevented transmission, while the mRNA did not.</li> </ul> <ul class="wp-block-list"> <li><em>HD-Ad-FS from the University of Toronto (Canada):</em> This is another intranasal viral vector vaccine. <a href="https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1430928/full">It was tested</a> in mice and hamsters. This is the second preclinical report for this vaccine. (<a href="https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00723-0">The first</a> tested the vaccine in mice.)</li> </ul> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><strong>Mucosal Covid vaccine overview </strong></em></p> <ul class="wp-block-list"> <li>5 mucosal vaccines are currently authorized for use, at least 1 in each of <a href="#authorizations">6 countries</a>. However, none have been authorized by a drug regulatory agency designated stringent, or listed, by WHO.</li> <li>30 mucosal vaccines have reached clinical trial, although some of the vaccines are no longer in development. The vaccines that have entered clinical trials are tracked in <a href="#mucosaltable">a table below</a>.</li> <li>In addition to the 5 authorized mucosal vaccines, 4 have reached phase 2 trials, and another 2 have reached phase 2/3 trial. <em> </em></li> </ul> <p><em>US Project NextGen-funded trials in this category:</em></p> <ul class="wp-block-list"> <li>Phase 1 for MPV/S-2P, the intranasal viral vector vaccine developed by the NIH’s National Institute of Allergy and Infectious Diseases (NIAID). <a href="https://clinicaltrials.gov/study/NCT06441968">This trial</a> for 60 participants began recruiting in <a href="https://www.nih.gov/news-events/news-releases/nih-sponsored-trial-nasal-covid-19-vaccine-opens">July 2024</a>.</li> </ul> <ul class="wp-block-list"> <li>Phase 2b (“mini-efficacy”) for the intranasal protein subunit vaccine from Castlevax (<a href="https://www.castlevax.com/products">planned</a> to start in the last quarter of 2024);</li> <li>Phase 2b for the intranasal live attenuated vaccine from Codagenix;</li> <li>Phase 2b for the oral viral vector vaccine from Vaxart (<a href="https://investors.vaxart.com/news-releases/news-release-details/vaxart-receives-barda-funded-project-nextgen-award-valued-453">planned</a> to start in 2024, possibly in US summer); and</li> </ul> <ul class="wp-block-list"> <li>Phase 2b for the intranasal viral vector vaccine from CyanVac (<a href="https://research.uga.edu/news/intranasal-covid-19-vaccine-headed-to-clinical-trials/">planned</a> to start in 2024, in US fall).</li> </ul> <p>Only the first of these trials (Phase 1) has been registered at ClinicalTrials.gov so far.</p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <h2 class="wp-block-heading" id="panSARS2"></h2> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading">Durable or “variant-proof” vaccine news</h4> <div style="height:21px" aria-hidden="true" class="wp-block-spacer"></div> <p>Two of the mucosal vaccines in the previous section had results which potentially put them in this category. There were no other reports for vaccines aiming to be “variant-proof.”</p> <div style="height:18px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><strong>Durable or “variant-proof” vaccine overview</strong></em></p> <p><em>Note: </em>This is a rather vague category, including vaccines that aim to be more durable. I’m not sure how many can be classified as aiming to be “variant-proof”.</p> <p><em>Authorized vaccine:</em></p> <p>There is one vaccine in this category that has been authorized by a drug regulatory authority designated by WHO has stringent, or listed – and tested against an mRNA vaccine:</p> <ul class="wp-block-list"> <li>LUNAR-COV19 (USA): This self-amplifying mRNA vaccine was authorized in Japan in November 2023.</li> </ul> <p><em>US Project NextGen-funded trials in this category:</em></p> <ul class="wp-block-list"> <li>Phase 1 for TNX-1800 from Tonix (aiming for lifelong immunity) (<a href="https://ir.tonixpharma.com/news-events/press-releases/detail/1436/tonix-pharmaceuticals-vaccine-candidate-tnx-1800">planned</a> to go into clinical trial in 2024);</li> </ul> <ul class="wp-block-list"> <li>Phase 2b (“mini-efficacy”) for Gritstone Bio (self-amplifying mRNA).</li> </ul> <ul class="wp-block-list"> <li>Phase 2b (“mini-efficacy”) for GeoVax (viral vector vaccine).</li> </ul> <p>These trials have not been registered at ClinicalTrials.gov as yet.</p> <div style="height:19px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <h2 class="wp-block-heading" id="pancoronavirus"></h2> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading">Pancoronavirus vaccine news</h4> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p>Pancoronavirus vaccines aim to provide protection not only from variants of the SARS virus that causes Covid, but also against the next new coronavirus to spread among humans. This month, 4 vaccines have joined this category, all from the US. As discussed above, the mucosal vaccine from Vaxart has also been tested against other coronaviruses.</p> <p></p> <ul class="wp-block-list"> <li><em>Om-S-MERS-RBD:</em> A protein subunit vaccine from Georgia State University (USA) based on both Omicron and MERS. It provided protection <a href="https://journals.asm.org/doi/full/10.1128/jvi.00376-24">in mice</a> challenged with Omicron, MERS, and the original SARS.</li> </ul> <ul class="wp-block-list"> <li><em>(Unnamed):</em> An mRNA vaccine from the University of North Carolina Chapel Hill (USA) <a href="https://www.science.org/doi/10.1126/science.abi4506">was compared</a> with current mRNA vaccines in challenge tests in mice for Covid, the original SARS, and several coronaviruses that occur in other animals. It provided protection. However, the mice in the comparison group showed less immune response, and were infected by the original SARS and one of the other coronaviruses.</li> </ul> <ul class="wp-block-list"> <li><em>(Unnamed): </em>A protein subunit vaccine vaccine from the Korea Research Institute of Bioscience and Biotechnology (South Korea) <a href="https://www.sciencedirect.com/science/article/abs/pii/S0166354224002006">was tested</a> in 2 types of mice. It is based on MERS. The mice showed immune responses to MERS. However, when challenged with Covid, only one type of mouse was protected.</li> </ul> <ul class="wp-block-list"> <li><em>(Unnamed)</em>: A protein subunit vaccine from State Key Laboratory of Respiratory Disease Guangzhou Medical University (China) <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202303366">was tested</a> in mice and macaques. This vaccine includes components of both types of SARS and MERS. The mice showed signs of immune responses to all 3, as well as some animal coronaviruses, and showed protection in challenge tests in comparison with control mice. The vaccinated macaques showed signs of immune response to all 3 as well.</li> </ul> <p>I also added another 2 reports for vaccines already in this collection, as well as a journal publication for a report previously in preprint for another. You can see these in the <a href="#pantable">table below</a>, marked with an asterisk.</p> <div style="height:16px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><strong>Pancoronavirus vaccine overview</strong></em></p> <p><a href="#pantable">A table below</a> this post keeps track of vaccines I’ve added to this category so far that have publicly available preclinical results.</p> <p>There are 5 of these vaccines in phase 1 clinical trials, with some results for 2 of them marked *:</p> <ul class="wp-block-list"> <li>DIOSynVax <em>(Cambridge University spin-off, UK)</em> – mRNA.</li> <li>INSERM/LinkInVax <em>(France)</em> – protein subunit.</li> <li>Osivax <em>(France)</em> – protein subunit (phase 1 trial fully recruited in June 2024).</li> <li>* VBI Vaccines <em>(Canada)</em> – eVLP.</li> <li>* Walter Reed Army Institute of Research <em>(WRAIR, USA)</em> – protein subunit.</li> </ul> <div style="height:19px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <h2 class="wp-block-heading" id="authorizations"></h2> <div style="height:32px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading"><em>Addendum 1: </em>List of authorized next generation Covid vaccines (with countries)</h4> <div style="height:23px" aria-hidden="true" class="wp-block-spacer"></div> <p>There are now 7 next-generation Covid vaccines authorized in 7 countries. Only one has been authorized by a drug regulatory agency designated stringent, or listed, by WHO – it’s in <strong>bold</strong>. I’ve listed the vaccines in 2 categories, in order of date of first authorization.</p> <p><em>Mucosal:</em></p> <ul class="wp-block-list"> <li>Razi-Cov Pars (Iran), intranasal protein subunit vaccine: Iran (October 2021).</li> <li>Sputnik (Russia), intranasal viral vector vaccine: Russia (April 2022).</li> <li>Convidecia (China), inhaled viral vector vaccine: China (September 2022), Morocco (November 2022), Indonesia (March 2023).</li> <li>iNCOVACC (USA/India), intranasal viral vector vaccine: India (September 2022).</li> <li>Pneucolin (China), intranasal viral vector vaccine: China (December 2022).</li> </ul> <p> <em>Self-amplifying mRNA:</em></p> <ul class="wp-block-list"> <li>Gemcovac (India): India (June 2022).</li> <li><strong>LUNAR-COV19 (USA): Japan (November 2023)</strong>.</li> </ul> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <h2 class="wp-block-heading" id="mucosaltable"></h2> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading"><em>Addendum 2: </em>Table of mucosal vaccines in clinical trials</h4> <div style="height:19px" aria-hidden="true" class="wp-block-spacer"></div> <p><em>* <em>Indicates new entry since previous update post.</em></em></p> <div style="height:17px" aria-hidden="true" class="wp-block-spacer"></div> <p><em>Note: Where there is a link to “All records” for a vaccine, that’s in my public Zotero collection for the vaccine, and it may include non-mucosal studies for that vaccine. <em><em>Notes</em> <em>on that collection are <a href="https://absolutelymaybe.plos.org/2022/01/26/boosters-and-mixed-schedules-covid-vaccines-at-the-2-year-mark-part-1/#collection">here</a>.</em></em> <em>For details on how I track Covid vaccine progress to maintain that collection, see my <a href="https://absolutelymaybe.plos.org/2023/05/01/a-process-update-on-covid-vaccine-tracking/">background post</a>.</em></em></p> <div style="height:14px" aria-hidden="true" class="wp-block-spacer"></div> <figure class="wp-block-table is-style-regular"><table class="has-pale-ocean-gradient-background has-background"><thead><tr><th>Vaccine, type, manufacturer</th><th>Mucosal version(s)</th><th>Phase 1 to 2 clinical trials</th><th>Phase 3+ trial(s)</th><th>Phase 3+ efficacy or immunogenicity results</th></tr></thead><tbody><tr><td>ACM-001<br><em>Protein subunit</em><br><br><em>ACM Biolabs (Singapore/Switzerland)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/ACM-001%20-%20ACM%20Biolabs/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05385991">Phase 1</a>.<br><strong><a href="https://acmbiolabs.com/acm-biolabs-announces-positive-topline-results-from-a-phase-i-trial-of-sars-cov-2-booster-vaccine-acm-001/">Results</a></strong> (press release only)</td><td></td><td></td></tr><tr><td>Ad5-nCoV (Convidecia Air)<br><em>Viral vector</em> <em>(adenovirus)</em><br><br><em>CanSino (China)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Ad5-nCov%20CanSino/library">All records</a>)</td><td>Inhaled through the mouth using a nebulizer.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04552366">Phase 1</a>. <strong><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00087-X/fulltext">Results</a></strong>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05043259">Phase 1/2</a>. <strong><a href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4000565">Results</a></strong> (plus <strong><a href="https://www.medrxiv.org/content/10.1101/2022.07.26.22278072v1">second later preprint</a></strong>).<br><br><a href="https://clinicaltrials.gov/study/NCT04840992">Phase 1/2</a>.<br><strong><a href="https://www.mdpi.com/2076-393X/12/3/292">Results</a></strong>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05330871">Phase 2</a> (aged 6-17 years).<br><br><a href="https://www.chictr.org.cn/showproj.html?proj=178220">Booster adapted for variant</a>.</td><td>10,420 people in China (<a href="https://clinicaltrials.gov/ct2/show/NCT05204589">Phase 3</a>).<br><strong><a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00350-X/fulltext">Results</a></strong>.<br><br>1,350 people (<a href="https://clinicaltrials.gov/ct2/show/NCT05442684">Phase 3</a>).<br><br>540 people, in Malaysia (<a href="https://clinicaltrials.gov/ct2/show/NCT05517642">Phase 3</a>).<br><br>904 people in China (<a href="https://www.chictr.org.cn/hvshowproject.aspx?id=148875">Phase 4</a>).<br><strong><a href="https://www.medrxiv.org/content/10.1101/2022.03.08.22271816v1">Results</a></strong>.<br><br>360 people (<a href="https://clinicaltrials.gov/ct2/show/NCT05303584">Phase 4</a>).<br><br>451 people (Phase 4). <strong><a href="https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2281355">Results</a></strong>.</td><td>904 people: Comparison after 2-dose course of inactivated vax: Convidecia injection vs inhaled, protein subunit, or CoronaVac booster (<strong><a href="https://www.medrxiv.org/content/10.1101/2022.03.08.22271816v1">Phase 4 results</a></strong>). Both injected & inhaled Convidecia had stronger impact on signs of immunity than the others; response after inhaled version was slower but longer-lasting than injected (which peaked then declined from day 14), better for Omicron though not as good for original virus. No measure of mucosal immunity used.<br><br>451 people: Comparison of different versions adapted for variant, including a bivalent version. Booster of inhaled Convidecia after previous vaccination with inactivated vaccine. Signs of immune response to Omicron were higher for the bivalent vaccine, though lower for the original SARS-CoV-2 strain.</td></tr><tr><td>Ad5-S<br><em>Viral vector (adenovirus)</em><br><br><em>State Key Laboratory for Infectious Disease/Guangzhou Enbao Biomedical Technology Co (China)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Ad5-S%20State%20Key%20Laboratory%20of%20Respiratory%20Disease%20Guangzhou%2FGuangzhou%20Enbao%20Biomedical%20Tech%20Co/library">All records</a>)<br><br></td><td>Intranasal.</td><td><a href="https://www.chictr.org.cn/showproj.html?proj=194109">Infection prevention study</a>.</td><td></td><td></td></tr><tr><td>AdCOVID<br><em>Viral vector</em> <em>(adenovirus)</em><br><br><em>AltImmune (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/AdCOVID%20Altimmune/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04679909">Phase 1</a>. <strong><a href="https://ir.altimmune.com/news-releases/news-release-details/altimmune-announces-update-adcovidtm-phase-1-clinical-trial">Results</a></strong> – press release only.<br><br><em>Discontinued after phase 1.</em></td><td></td><td></td></tr><tr><td>AdS+N<br><em>Viral vector (adenovirus)</em><br><br><em>ImmunityBio (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/AdS%2BN%20(hAd5%20S-Fusion%20%2B%20N-ETSD)%20ImmunityBio,Mucosal%20vaccine/library">All records</a>)<br><br></td><td>Intranasal, oral capsule, or sublingual.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04732468">Phase 1</a> (oral).<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT04591717">Phase 1</a> (sublingual).</td><td></td><td></td></tr><tr><td>AeroVax (Ad5-triCoV)<br><em>Viral vector (adenovirus)</em><br><br><em>McMaster University/Canadian Institutes of Health Research (Canada)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/AeroVax%20(ChAd-triCoV%2FMac)%20McMaster/library">All records</a>)</td><td>Aerosol.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05094609">Phase 1</a> (& ChAd-triCoV/Mac).<br><br><a href="https://clinicaltrials.gov/study/NCT06381739">Phase 2</a>.</td><td></td><td></td></tr><tr><td>Avacc 10<br><em>Protein subunit</em><br><br><em>Intravacc (Netherlands)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Avacc%2010%20-%20Intravacc/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05604690">Phase 1</a>.<br><strong><a href="https://www.globenewswire.com/news-release/2024/03/26/2852111/0/en/Intravacc-announces-positive-data-of-first-in-human-intranasal-OMV-based-vaccine-for-SARS-CoV-2.html">Results</a></strong> (press release only)</td><td></td><td></td></tr><tr><td>bacTRL-Spike-1<br><em>Live attenuated</em><br><br><em>Symvivo (Canada)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/bacTRL-Spike-1%20Symvivo/library">All records</a>)</td><td>Oral.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04334980">Phase 1</a>.</td><td></td><td></td></tr><tr><td>BBV154 (iNCOVACC)<br><span><i><em>Viral vector</em> <em>(adenovirus)</em></i></span><br><br><em>Bharat Biotech (India)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/BBV154%20Bharat/library">All records</a>)<br><br>This vaccine is ChAd-SARS-CoV-2-S<br><em>Washington University in St Louis (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/ChAd-SARS-CoV-2-S%20(BBV154)%20Washington%20Uni%20St%20Louis%2FPrecision%20Virologics%2FBharat/library">All records</a>)<br><br></td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04751682">Phase 1</a>.<br><br><a href="http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=59902">Phase 2</a>.<br><br>Small amount of data from these trials in the <a href="https://www.bharatbiotech.com/images/incovacc/incovacc-smpc.pdf">drug product information</a>.<br><br><a href="http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=59216">Phase 2/3</a>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05639998">Phase 2</a>.</td><td>In India, 2-dose course of BBV154 vs 2-dose course of injected Covaxin inactivated vaccine (<a href="http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=65443">Phase 3</a> – and <a href="https://clinicaltrials.gov/ct2/show/NCT05522335">here</a>).<br><strong><a href="https://www.nature.com/articles/s41541-023-00717-8">Results </a></strong>(<a href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4342771">previously in preprint</a>).<br><br><em>See also the <a href="https://www.bharatbiotech.com/images/incovacc/incovacc-smpc.pdf">drug product information</a>.</em><br><br>875 people in India, booster trial (<a href="http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=65451">Phase 3</a>).</td><td>2,971 previously unvaxed people were assigned for the intranasal iNCOVACC, 161 for injected Covaxin. This trial did not aim to assess disease outcomes. It took place during the first Omicron wave.<br><br>Signs of immune response were higher for iNCOVACC than Covaxin. <br><br>Adverse events rate very low (5% local and 3% systemic) – lower than for comparison group.</td></tr><tr><td>B/HPIV3/S-6P<br><em>Viral vector (parainfluenza)</em><br><br><em>NIH’s National Institute of Allergy and Infectious Diseases (NIAID) (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/B%2FHPIV3%2FS-6P%20NIAID%20(parainfluenza)/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/study/NCT06026514">Phase 1</a>.<br>Fully recruited by early July 2024.</td><td></td><td></td></tr><tr><td>BV-AdCoV-1<br><em>Viral vector (adenovirus)</em><br><br><em>Wuhan BravoVax</em><br><em>(China)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/BV-AdCoV-1%20Wuhan%20BravoVax/items/NLEUGD29/library">All records</a>)</td><td>Inhaled through the mouth using a nebulizer.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05706324">Phase 1</a>.</td><td></td><td></td></tr><tr><td>ChAdOx1<br><em>Viral vector (adenovirus)</em><br><br><em>Oxford University (UK)</em><br><em>(This is the AstraZeneca vax)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/ChAdOx1%20nCov-19%20Oxford-AstraZeneca,Mucosal%20vaccine/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04816019">Phase 1</a>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05007275">Phase 1</a>.<br><br><strong><a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00480-7/fulltext">Results</a></strong>.</td><td></td><td></td></tr><tr><td>CoV2-OGEN1<br><em>Protein subunit</em><br><br><em>US Specialty Formulations/VaxForm</em> <em>(USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/CoV2-OGEN1%20USSF%2FVaxform/library">All records</a>)</td><td>Oral.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04893512">Phase 1</a>.<br>(Fully recruited, final dose in November 2022.)<br><a href="https://www.einpresswire.com/article/654212950/us-specialty-formulations-completes-phase-i-of-clinical-trials-for-the-qyndr-vaccine">Press release</a> stating successful (without data) and progressing to phase 2 trial. </td><td></td><td></td></tr><tr><td>COVI-VAC<br><em>Live attenuated</em><br><br><em>Codagenix (USA, with the Serum Institute of India)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/COVI-VAC%2FCoviLiv%20Codagenix/library">All records</a>)</td><td>Intranasal.</td><td><br><a href="https://clinicaltrials.gov/ct2/show/NCT04619628">Phase 1</a>.<br><a href="https://www.prnewswire.com/news-releases/codagenix-announces-safety-and-immunogenicity-data-from-phase-1-covid-19-intranasal-vaccine-trial-and-intent-to-progress-to-phase-23-studies-301382120.html?tc=eml_cleartime">Press release</a> in 2021 stating successful (without data) and progressing to phase 2/3.<br>Preliminary <strong><a href="https://europepmc.org/article/PMC/PMC8644858">results</a></strong> (conference abstract in 2021) and in a 2022 <a href="https://codagenix.com/codagenix-intranasal-covid-19-vaccine-shows-potent-cellular-immune-response-against-conserved-viral-proteins-indicating-potential-for-immunogenicity-against-omicron-and-future-variants-in-phase-1-dat/">press release</a>.<br><strong><a href="https://www.prnewswire.com/news-releases/codagenix-announces-late-breaking-presentation-of-positive-clinical-immunogenicity-data-for-covid-19-vaccine-candidate-coviliv-at-idweek-2023-301952953.html">Results</a></strong> in 2023 (press release only).<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05233826">Phase 1</a> (booster).</td><td>Phase 2/3, as part of the <a href="https://www.isrctn.com/ISRCTN15779782">WHO Solidarity Trial for Vaccines</a> in <a href="https://cvd-mali.org/en/solidarity-trial-vaccines-enters-major-new-phase-recruiting-now/">Mali</a>, Colombia, Kenya, Philippines, Sierra Leone. Fully recruited by July 2024. (<a href="https://cdn.who.int/media/docs/default-source/blue-print/who-covid-2019_solidarityvaccinetrial_14-june-2021_clean_for-registry.pdf?sfvrsn=77b2110a_11">Protocol</a>.)</td><td></td></tr><tr><td>CVXGA1-001<br><em>Viral vector (parainfluenza)</em><br><br><em>CyanVac/Blue Lake Tech (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/CVXGA1-001%20-%20Uni%20of%20Georgia%2FCyanVac/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04954287">Phase 1</a>. <strong><a href="https://www.bluelakebiotechnology.com/news/blue-lake-biotechnology-to-highlight-preliminary-covid-phase-1-data-at-bio-ceo-conference">Results</a></strong> (press release only).<br><a href="https://clinicaltrials.gov/ct2/show/NCT05736835">Phase 2</a>.</td><td></td><td></td></tr><tr><td>DNS1-RBD (Pneucolin)<br><em>Viral vector (influenza)</em><br><br><em>Beijing Wantai BioPharm (China)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/dNS1-RBD%20Beijing%20Wantai%20Biological%20Pharmacy%20Enterprise/library">All records</a>)</td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04809389">Phase 1</a>.<br><a href="https://clinicaltrials.gov/ct2/show/NCT05200741">Phase 2</a>.<br><strong><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00131-X/fulltext">Joint results</a></strong>.</td><td>30,990 participants in Colombia, Philippines, South Africa, Vietnam.<br><strong><a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00349-1/fulltext">Results</a></strong> (<a href="https://www.researchsquare.com/article/rs-2407050/v1">previously in preprint</a>.)<br><br>5,400 participants in Ghana (<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=17163">Phase 3</a>).</td><td>Comparison of 2 doses of intranasal vaccine 14 days apart, with placebo control, during circulation of Omicron. Included >13,000 previously unvaccinated people.<br><br>Efficacy shown 90 days after 2nd dose. There was some decline at 180 days.<br><br><em>Efficacy against symptomatic Covid:</em><br>No previous vax: 55.2% (CI 13.8 to 76.7)<br>Inactivated: 38.2% (CI -49.2 to 74.4)<br>Viral vector: 39.9% (CI -16.7 to 69.1)<br>mRNA: 10.1% (CI -45.9 to 44.5)<br><br><em>Efficacy against severe Covid:</em><br>No previous vax: 66.7% (CI 8.3 to 87.9)<br>Inactivated: 54.6% (CI -47.3 to 86.0)<br>Viral vector: 50.0% (CI -6.8 to 76.6)<br>mRNA: 19.5% (CI -39.2 to 53.4)<br><br><em>Efficacy against hospitalization:</em><br>100% (CI -9.2 to 100)<br><br>Adverse events were very low – similar to placebo. Less than 8% of people had a runny and/or blocked nose or sore throat.</td></tr><tr><td>GAM-COVID-VAC (rAd26-S – Sputnik Light)<br><em>Viral vector (adenovirus)</em><br><br><em>Gamaleya Research Institute (Russia)</em></td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05248373">Phase 1/2</a><br></td><td>7,000 participants in Russia (<a href="https://grls.rosminzdrav.ru/CiPermitionReg.aspx?PermYear=0&DateInc=&NumInc=&DateBeg=&DateEnd=&Protocol=&RegNm=&Statement=&ProtoId=&idCIStatementCh=&Qualifier=&CiPhase=&RangeOfApp=&Torg=&LFDos=&Producer=%d0%9d%d0%b0%d1%86%d0%b8%d0%be%d0%bd%d0%b0%d0%bb%d1%8c%d0%bd%d1%8b%d0%b9+%d0%b8%d1%81%d1%81%d0%bb%d0%b5%d0%b4%d0%be%d0%b2%d0%b0%d1%82%d0%b5%d0%bb%d1%8c%d1%81%d0%ba%d0%b8%d0%b9+%d1%86%d0%b5%d0%bd%d1%82%d1%80+%d1%8d%d0%bf%d0%b8%d0%b4%d0%b5%d0%bc%d0%b8%d0%be%d0%bb%d0%be%d0%b3%d0%b8%d0%b8+%d0%b8+%d0%bc%d0%b8%d0%ba%d1%80%d0%be%d0%b1%d0%b8%d0%be%d0%bb%d0%be%d0%b3%d0%b8%d0%b8&Recearcher=&sponsorCountry=&MedBaseCount=&CiType=&PatientCount=&OrgDocOut=2&Status=1%2c2%2c3%2c4%2c&NotInReg=0&All=0&PageSize=8&order=numperm&orderType=desc&pagenum=1">Phase 3</a> or phase 2/3 – not clear).</td><td></td></tr><tr><td>Mambisa<br><em>Protein subunit</em><br><br><em>Centre for Genetic Engineering & Biotechnology </em>(<em>CIGB) (Cuba)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Mambisa%20CIBG%2FBioCubaFarma/library">All records</a>)</td><td>Intranasal drops.</td><td><a href="https://rpcec.sld.cu/en/trials/RPCEC00000345-En">Phase 1/2</a>.<br><br><a href="https://rpcec.sld.cu/en/trials/RPCEC00000382-En">Phase 1/2</a>.<br><strong><a href="https://www.prensa-latina.cu/2022/04/27/candidato-vacunal-mambisa-de-cuba-cumple-expectativas-de-estudios">Results</a></strong> (report of a conference presentation).<br><br><a href="https://rpcec.sld.cu/en/trials/RPCEC00000398-En">Phase 2</a>.</td><td></td><td></td></tr><tr><td>MPV/S-2P<br><em>Viral vector (murine pneumonia)</em><br><br><em>National Institute of Allergy and Infectious Diseases (NIAID)<br>(USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/MPV%2FS-2P%20NIAID/library">All records</a>)</td><td>Intranasal drops.</td><td><a href="https://clinicaltrials.gov/study/NCT06441968">Phase 1</a>.</td><td></td><td></td></tr><tr><td>MV-014-212<br><em>Viral vector</em><br><em>(RSV)</em><br><br><em>Meissa Vaccines (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/MV-014-212%20Meissa%20Vaccines/library">All records</a>)</td><td>Intranasal drops or spray. </td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04798001">Phase 1</a>.<br><strong><a href="https://www.businesswire.com/news/home/20211028005281/en/Meissa-Announces-Positive-Preliminary-Clinical-Data-on-Safety-and-Immunogenicity-of-Intranasal-COVID-19-Vaccine">Results</a></strong> (press release).</td><td></td><td><em>This vaccine is in limbo because of the <a href="https://www.fiercebiotech.com/biotech/meissa-vaccines-future-limbo-due-current-fundraising-climate-ceo">company’s financial difficulties</a>.</em></td></tr><tr><td>MVA-SARS-2ST<br><em>Viral vector (MVA)</em><br><br><em>German Centre for Infection Research (DZIF)/IDT Biologika</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/MVA-SARS-2S%20German%20Centre%20for%20Infection%20Research%20(DZIF)%2FIDT%20Biologika/library">All records</a>)</td><td>Inhalation.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05226390">Phase 1</a>.</td><td></td><td></td></tr><tr><td>CVAX-01<br><em>Viral vector (Newcastle Disease Virus)</em><br><br><em>Castlevax/Icahn Mt Sinai</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/CVAX-01%20Castlevax%2FIcahn%20School%20of%20Medicine%20Mt%20Sinai/library">All records</a>)<br></td><td>Intranasal.</td><td><a href="https://www.clinicaltrials.gov/study/NCT05181709">Phase 1</a>.<br><strong><a href="https://www.mountsinai.org/about/newsroom/2023/promising-results-of-next-generation-intranasal-covid-booster-vaccine-implications-for-infection-prevention-and-transmission">Results</a></strong> (press release).</td><td></td><td></td></tr><tr><td>Ad5-S-Omicron BA.1<br><em>Viral vector (Adenovirus 5)</em><br><br><em>Guangzhou Medical University/Guangzhou National Laboratory</em><br><em>(China)</em><br><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/NB2155%20Guangzhou%20Medical%20University%2FGuangzhou%20National%20Laboratory/library">All records</a>)</td><td>Intranasal</td><td><a href="https://www.chictr.org.cn/showproj.html?proj=194109">Phase 1</a>.<br><strong><a href="https://www.nature.com/articles/s41392-024-01906-0">Results</a></strong>.</td><td></td><td></td></tr><tr><td>Patria (NDV-HXP-S/AVX-COVID-12-HEXAPRO)<br><em>Viral vector (Newcastle Disease Virus)</em><br><br><em>Laboratorio Avi-Mex (Mexico)</em><br>(All records on <a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/NDV-HXP-S%2FPatria%20(AVX-COVID-12-HEXAPRO)%20Avimex/library">Patria</a>, see also CVAX-01 for early development.)<br><br></td><td>Intranasal.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04871737">Phase 1</a>.<br><strong><a href="https://www.nature.com/articles/s41541-023-00662-6">Results</a></strong>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05205746">Phase 2</a>.<br><strong><a href="https://www.medrxiv.org/content/10.1101/2024.02.11.24302594v1">Results</a></strong>.</td><td>Phase 2/3 for injected version only: <strong><a href="https://www.medrxiv.org/content/10.1101/2024.02.11.24302530v1">Results</a></strong>.</td><td><br></td></tr><tr><td>PRAK-03202<br><em>Protein subunit</em><br><br><em>Oravax (USA) [Oravax was established by OraMed (Israel) to develop this vaccine, using Premas Biotech’s PRAK-03202 and their oral vaccine technology]</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/PRAK-03202%20Oravax%2FOramed/library">All records</a> on oral PRAK-03202, and <a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/PRAK%E2%88%9203202%20Premas%20Biotech/library">on intramuscular version</a>)</td><td>Oral.</td><td><a href="https://sanctr.samrc.ac.za/TrialDisplay.aspx?TrialID=5673">Phase 1</a> (in South Africa).<br><strong><a href="https://www.prnewswire.com/news-releases/oramed-subsidiary-oravax-reports-positive-preliminary-phase-1-data-for-its-oral-covid-19-vaccine-301643522.html">Results </a></strong>(press release only).</td><td></td><td></td></tr><tr><td>Razi-Cov Pars<br><em>Protein subunit</em><br><br><em>Razi Vaccine & Serum Research Institute (Iran)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Razi%20Cov%20Pars%20-%20Razi%20Vaccine%20%26%20Serum%20Research%20Institute/library">All records</a>)</td><td>Intranasal (third dose after 2 injections).</td><td><a href="https://www.irct.ir/trial/52975">Phase 1</a>.<br><strong><a href="https://www.mdpi.com/2076-393X/11/2/455">Results</a></strong>.<br><br><a href="https://www.irct.ir/trial/55238">Phase 2</a>.<br><strong><a href="https://jpharmsci.org/article/S0022-3549(23)00408-2/fulltext">Results</a></strong>.<br><br><a href="https://www.irct.ir/trial/61378">Phase 1 to 2</a> (in 12-17 year-olds).<br><br><a href="https://en.irct.ir/trial/67073">Phase 4 (Booster)</a>.<br><br><a href="https://en.irct.ir/trial/61378">Phase 1 to 2</a> (in 5-17 year-olds).</td><td>41,128 people in Iran, comparing the 3-dose course to 2-dose inactivated Sinopharm Beijing vax, only partially randomized (<a href="https://www.irct.ir/trial/58143">Phase 3</a>).<br><strong><a href="https://www.cell.com/heliyon/fulltext/S2405-8440(24)03401-7">Results</a></strong><br>(Previous <a href="https://farsnews.ir/en/news/14001123000446/Razi-Insie-Chief-Underlines-High-Efficiency-f-Iran-Made-Razi-Cv-Pars">media report</a> for the <a href="https://www.tasnimnews.com/fa/news/1400/11/20/2659676/%D8%A7%D8%AB%D8%B1%D8%A8%D8%AE%D8%B4%DB%8C-%D9%88%D8%A7%DA%A9%D8%B3%D9%86-%D8%B1%D8%A7%D8%B2%DB%8C-3-%D8%A8%D8%B1%D8%A7%D8%A8%D8%B1-%D8%B3%DB%8C%D9%86%D9%88%D9%81%D8%A7%D8%B1%D9%85-%D8%A7%D8%B3%D8%AA-%D8%A7%D9%85%DA%A9%D8%A7%D9%86-%D8%A7%D8%B3%D8%AA%D9%81%D8%A7%D8%AF%D9%87-%D8%A7%D8%B2-%D8%AF%D9%88%D8%B2-%D8%A7%D8%B3%D8%AA%D9%86%D8%B4%D8%A7%D9%82%DB%8C-%D8%A8%D9%87-%D8%B9%D9%86%D9%88%D8%A7%D9%86-%D8%AF%D9%88%D8%B2-%D8%B3%D9%88%D9%85-%D9%88%D8%A7%DA%A9%D8%B3%D9%86-%D9%87%D8%A7%DB%8C-%DA%A9%D8%B1%D9%88%D9%86%D8%A7">first 24,000</a> participants.)</td><td>The authors concluded Razi-Cov Pars was non-inferior to the inactivated vaccine, with similarly very low adverse events. However, the trial could not establish whether there was an advantage to an intranasal dose. </td></tr><tr><td>SC-Ad6-1<br><em>Viral vector (adenovirus)</em><br><br><em>Moat Bio/Tetherex (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/SC-Ad6-1%20Mayo%20Clinic%2FTetherex%20Pharmaceuticals">All records</a>)</td><td>Intranasal and inhaled.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04839042">Phase 1</a>.<br>Trial expanded to add an inhaled version (from 130 to 190 people). Results so far briefly mentioned in <a href="https://www.prnewswire.com/news-releases/moat-biotechnology-raises-6-5m-in-first-close-for-intranasalinhaled-covid-19-vaccine-301849665.html">press release</a>.</td><td></td><td></td></tr><tr><td>SpikoGen<br><em>Protein subunit</em><br><br><em>Vaxine (Australia)</em><br><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Mucosal%20vaccine,SpikoGen%20(Covax-19)%20Vaxine%2FCinnagen/library">All records on mucosal</a> and <a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/SpikoGen%20(Covax-19)%20Vaxine%2FCinnagen/library">on all forms</a>.)<br><br></td><td>Oral/sublingual.</td><td><a href="https://clinicaltrials.gov/study/NCT06355232">Phase 1</a>.</td><td></td><td></td></tr><tr><td>(Unnamed)<br><em>Inactivated bacteria</em><br><br><em>DreamTec (Hong Kong)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/Unnamed%20-%20DreamTec/search/dreamtec/titleCreatorYear/item-list">All records</a>)</td><td>Oral.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05057923">Phase 1</a>.<br><a href="https://clinicaltrials.gov/ct2/show/NCT05158855">Phase 1</a>.<br><a href="https://clinicaltrials.gov/ct2/show/NCT05239923">Phase 1</a>.<br><br><em>Note: </em>An article of <a href="https://www.mdpi.com/2076-393X/10/11/1852">preclinical results has been retracted</a> over lack of ethics committee approval. </td><td></td><td></td></tr><tr><td>VXA-CoV2-1/VXA-CoV2-1.1-S<br><em>Viral vector</em><br><em>(adenovirus)</em><br><br><em>Vaxart (USA)</em><br>(<a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/tags/VXA-CoV2-1%20-%20Vaxart/library">All records</a>)</td><td>Tablets.</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04563702">Phase 1</a>.<br><strong><a href="https://www.medrxiv.org/content/10.1101/2022.07.16.22277601v1">Results</a></strong>.<br><br><a href="https://clinicaltrials.gov/ct2/show/NCT05067933">Phase 2</a>. (Started October 1, 2021.)<br><strong><a href="https://investors.vaxart.com/news-releases/news-release-details/vaxart-announces-positive-top-line-phase-ii-clinical-study-data">Results</a></strong> (press release).<br><br>* Additional <strong><a href="https://investors.vaxart.com/static-files/eb9fdda7-9db1-4dad-93ee-c95d943c46ba">brief results</a></strong> in presentation.</td><td></td><td><br></td></tr></tbody></table></figure> <div style="height:23px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <h2 class="wp-block-heading" id="pantable"></h2> <div style="height:35px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading">Addendum 3: <strong><em>Pancoronavirus vaccines with preclinical results</em></strong></h4> <div style="height:24px" aria-hidden="true" class="wp-block-spacer"></div> <p>* <em>Indicates new entry since previous update post. </em> </p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <figure class="wp-block-table alignleft is-style-regular"><table class="has-pale-ocean-gradient-background has-background"><thead><tr><th>Developer<br><em>Country</em><br><br><em>Vaccine name</em></th><th>Type of:<br><br>Vaccine<br><br><em>Coronavirus</em></th><th>Preclinical results</th><th>Clinical trial status</th></tr></thead><tbody><tr><td>Academia Sinica Taiwan<br><em>(Taiwan)</em><br><br><em>(Unnamed)</em></td><td>mRNA<br><br><em>All</em></td><td><a href="https://www.pnas.org/doi/10.1073/pnas.2314392120">Non-primate</a></td><td></td></tr><tr><td>Baylor College of Medicine<br><em>(USA)<br><br>(Unnamed)</em></td><td>Protein subunit<br><br><em>Beta</em></td><td><a href="https://www.nature.com/articles/s41541-024-00924-x">Non-primate</a></td><td></td></tr><tr><td>Beijing University of Chemical Technology<br><em>(China)</em><br><br><em>(Unnamed)</em></td><td>Live attenuated pangolin coronavirus<br><br><em>All</em></td><td><a href="https://www.researchsquare.com/article/rs-3371123/v1">Non-primate</a></td><td></td></tr><tr><td>California Institute of Technology (Caltech)<br><em>USA</em><br><br><em>Mosaic-8b</em></td><td>Protein subunit<br><br><em>Beta</em></td><td><a href="https://www.science.org/doi/10.1126/science.abf6840">Non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2023.02.24.529520v1">Non-primate</a><br><br><a href="https://www.sciencedirect.com/science/article/pii/S107476132200560X">Non-primate</a><br><br><a href="https://www.science.org/doi/10.1126/science.abq0839">Primate, non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2024.02.08.576722v2">Primate, non-primate</a> (update) (<a href="https://www.biorxiv.org/content/10.1101/2024.02.08.576722v1">previous version</a>)<br><br><a href="https://www.nature.com/articles/s41565-024-01655-9">Non-primate</a> (new version of the vaccine)<br><br>* <a href="https://www.cell.com/cell/fulltext/S0092-8674(24)00846-8">Primate and non-primate</a></td><td></td></tr><tr><td>Charité Universitätsmedizin Berlin<br><em>Germany</em><br><br><em>NILV-PanCoVac</em></td><td>Viral vector<br><br><em>All</em></td><td><a href="https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166765/full">Non-primate</a> (mucosal)</td><td></td></tr><tr><td>China Cuba Joint Innovation Center<br><em>China, Cuba</em><br><br><em>Unnamed</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.mdpi.com/1999-4915/16/3/418">Non-primate</a> (mucosal)</td><td></td></tr><tr><td>Codiak<br><em>USA</em><br><br><em>exoVACC Pan Beta Coronavirus</em></td><td>Protein subunit<br><br><em>Beta</em><br></td><td><a href="https://www.sciencedirect.com/science/article/pii/S0092867421007972">Article on development</a><br><br>Non-primate (<a href="https://s3.us-east-1.amazonaws.com/codiak-assets.investeddigital.com/publications/Codiak-WVIC-Poster-for-exoVACC-120221-FINAL.pdf">conference slides</a>)<br><br>Non-primate<br>(<a href="https://s3.us-east-1.amazonaws.com/codiak-assets.investeddigital.com/publications/Codiak-World-Vaccine-Congress-April-20-2022-Final-V2.pdf">conference slides</a>)</td><td><em>(This company <a style="font-family: inherit;font-size: inherit;font-weight: inherit" href="https://cases.stretto.com/codiak">began proceedings</a></em><br><em><span style="font-family: inherit;font-size: inherit;font-weight: inherit;background-color: initial;color: initial">in bankruptcy court</span>. See news.)</em></td></tr><tr><td>DIOSynvax<br><em>UK</em><br><br><em>DIOS-CoVax/<br>pEVAC-PS</em></td><td>mRNA<br><br><em>Sarbeco</em></td><td><a href="https://www.researchsquare.com/article/rs-995273/v1">Non-primate</a><br><br><a href="https://www.nature.com/articles/s41551-023-01094-2">Non-primate</a></td><td><a href="https://www.isrctn.com/ISRCTN87813400">Phase 1 trial</a> (incl. protocol)<br><em>(Up to 36 participants in the UK)</em><br>Began <a href="https://www.cam.ac.uk/stories/DIOSCoVax_safetytrial">December 2021</a>.<br>Fully recruited.<br><a href="https://www.nihr.ac.uk/news/trials-launched-for-revolutionary-needle-free-coronavirus-vaccine/33575">Expanded </a>to another city – no trial register entry found.</td></tr><tr><td>Duke University<br><em>USA</em><br><br><em>RBD–scNP</em></td><td>Protein subunit<br><br><em>Beta</em><br></td><td><a href="https://www.nature.com/articles/s41586-021-03594-0">Primate</a><br><br><a href="https://www.nature.com/articles/s41586-021-03594-0">Primate</a><br><br><a href="https://www.nature.com/articles/s41467-022-33985-4">Primate, non-primate</a><br><br><a href="https://www.cell.com/cell-reports/pdf/S2211-1247(23)01260-3.pdf">Non-primate </a>(<a href="https://www.biorxiv.org/content/10.1101/2023.05.22.540829v1">previously in preprint</a>)<br><br><a href="https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1">Primate, non-primate</a></td><td></td></tr><tr><td>Francis Crick Institute<br><em>UK</em><br><br><em>(Unnamed)</em></td><td>Protein subunit with DNA boost<br><br><em>All</em></td><td><a href="https://www.science.org/doi/10.1126/scitranslmed.abn3715">Non-primate</a></td><td></td></tr><tr><td>Fudan University<br><em>China</em><br><br><em>HR1LS</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.nature.com/articles/s41422-022-00612-2">Primate, non-primate</a><br><br><a href="https://www.nature.com/articles/s41422-022-00631-z">Primate</a><br><br><a href="https://www.pnas.org/doi/full/10.1073/pnas.2221713120">Primate</a><br><br><a href="https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2244084">Non-primate</a></td><td></td></tr><tr><td>Georgia State University, University of Iowa<br><em>USA</em><br><br><em>SARS2-S (SARS-RBD)</em></td><td>mRNA<br><br><em>Sarbeco</em></td><td><a href="https://www.cell.com/iscience/fulltext/S2589-0042(22)01963-0">Non-primate</a><br><br><a href="https://www.mdpi.com/2076-393X/12/6/605">Non-primate</a></td><td></td></tr><tr><td>* Georgia State University<br><em>USA</em><br><br><em>Om-S-MERS-RBD</em></td><td>Protein subunit<br><br><em>All</em></td><td><a href="https://journals.asm.org/doi/full/10.1128/jvi.00376-24">Non-primate</a></td><td></td></tr><tr><td>Georgia State University<br><em>USA<br><br>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td>* <a href="https://www.cell.com/iscience/fulltext/S2589-0042(23)02110-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223021107%3Fshowall%3Dtrue">Non-primate</a><br><br><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202105378">Primate, non-primate</a><br><br><a href="https://www.nature.com/articles/s41541-024-00922-z">Non-primate</a></td><td></td></tr><tr><td>Guangdong Pharmaceutical University<br><em>China</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>All</em></td><td><a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.29115">Non-primate</a></td><td></td></tr><tr><td>* Korea Research Institute of Bioscience and Biotechnology<br><em>South Korea<br><br>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.sciencedirect.com/science/article/abs/pii/S0166354224002006">Non-primate</a></td><td></td></tr><tr><td>INSERM Vaccine Research Institute/LinKinVax<br><em>France</em><br><br><em>PanCov</em> (<em>CD40.CoV2/RBDv)</em></td><td>Protein subunit<br><em>Sarbeco</em></td><td><a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00243-2/fulltext">Non-primate</a><br><br><a href="https://www.nature.com/articles/s41467-021-25382-0">Primate, non-primate</a><br><br><a href="https://elifesciences.org/articles/75427">Primate</a><br><br><a href="https://www.croiconference.org/wp-content/uploads/sites/2/posters/2023/CROI-Poster-Nguema020223-133204312648122137.pdf">Non-primate</a> <em>(conference poster)</em></td><td><a href="https://clinicaltrials.gov/study/NCT06255626">Phase 1/2 trial</a><br><em>(Up to 240 participants in France)</em><br>Booster trial, planned to start recruiting in February 2024.</td></tr><tr><td>Osivax<br><em>France</em><br><br>OVX033</td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188605/full">Non-primate</a></td><td><a href="https://clinicaltrials.gov/study/NCT06128382">Phase 1 trial</a><br><em>(48 participants in France)</em><br>First participant vaccinated in <a href="https://osivax.com/pressrelease-firstpatient-of-ovx033-fih/">February 2024</a>.<br>Fully recruited in <a href="https://osivax.com/osivax-completes-enrollment-for-phase-1-trial-with-broad-spectrum-sarbecovirus-vaccine-candidate-ovx033/">June 2024</a>.</td></tr><tr><td>Pennsylvania State University<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>All</em></td><td><a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202206055">Non-primate</a></td><td></td></tr><tr><td>Scripps Research Institute<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>Beta</em></td><td><br><br><a href="https://www.science.org/doi/10.1126/sciadv.abj3107">Non-primate</a></td><td></td></tr><tr><td>SK Bioscience/ Uni of Washington/Uni of North Carolina at Chapel Hill<br><em>South Korea, USA</em><br><br><em>GBP511</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.science.org/doi/epdf/10.1126/scitranslmed.adg7404">Primate, non-primate</a> <em>(testing Covid vaccine GBP510 against other sarbecoviruses)</em><br></td><td><em><a href="https://cdn.who.int/media/docs/default-source/blue-print/dev_sk-biosciences_king_whoconsultation_pan-sarbecovirus_28jan2022.pdf?sfvrsn=53bc4a23_7">More on plans for adapting this vaccine</a> – GBP510 authorized as SKYCovione.</em> <em>See the University of Washington research listed below in this table.</em></td></tr><tr><td>Stanford University<br><em>USA</em><br><br><em>DCFHP-alum</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.nature.com/articles/s41467-023-37417-9">Primate</a><br><em><a href="https://www.nature.com/articles/s41467-023-42061-4">Erratum</a> </em>(correction to legend in a figure).<br><br><a href="https://www.biorxiv.org/content/10.1101/2023.06.27.546764v2">Non-primate</a><br></td><td></td></tr><tr><td>* State Key Laboratory of Respiratory Disease Guangzhou Medical University<br><em>China</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202303366">Primate and non-primate</a></td><td></td></tr><tr><td>Sun Yat-Sen University<br><em>China</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202301034">Non-primate</a></td><td></td></tr><tr><td>University of California Irvine/Techimmune<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Viral vector<br><br><em>Beta</em></td><td><a href="https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1328905/full">Non-primate </a>(<a href="https://www.biorxiv.org/content/10.1101/2023.05.24.541850v1">previously in preprint</a>)<br><br><a href="https://journals.asm.org/doi/full/10.1128/jvi.01096-23">Non-primate</a> (mucosal) (<a href="https://www.biorxiv.org/content/10.1101/2023.05.23.542024v1">previously in preprint</a>)<br><br><a href="https://www.biorxiv.org/content/10.1101/2024.02.14.580225v1">Non-primate</a><br><br><em>(There was also a paper about this vaccine’s development <a href="https://journals.aai.org/jimmunol/article/206/11/2566/234252/Genome-Wide-B-Cell-CD4-and-CD8-T-Cell-Epitopes">in 2021</a>.)</em></td><td></td></tr><tr><td>University of Houston/Auravax<br><em>USA</em><br><br><em>NanoSTING-NS</em></td><td>Protein subunit<br>(intranasal)<br><br><em>Sarbeco</em></td><td><a href="https://www.sciencedirect.com/science/article/pii/S2589004221010051">Non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2022.07.14.500068v1">Non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2022.07.14.500068v1">Non-primate</a><br><br><a href="https://www.nature.com/articles/s41467-024-50133-2">Primate, non-primate</a></td><td></td></tr><tr><td>University of North Carolina at Chapel Hill<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Viral vector<br><br><em>Sarbeco</em></td><td>* <a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00337-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723003376%3Fshowall%3Dtrue">Non-primate</a><br>(<a href="https://www.biorxiv.org/content/10.1101/2022.11.28.518175v1">Previously in preprint</a>)</td><td></td></tr><tr><td>* University of North Carolina at Chapel Hill<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>mRNA<br><br><em>Sarbeco</em></td><td><a href="https://www.science.org/doi/10.1126/science.abi4506">Non-primate</a></td><td></td></tr><tr><td>University of Toronto<br><em>Canada</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbec</em>o</td><td><a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00402-3">Non-primate</a></td><td></td></tr><tr><td>University of Washington<br>USA<br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>Sarbeco</em></td><td><a href="https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00422-5">Non-primate</a><br>(<a href="https://www.biorxiv.org/content/10.1101/2023.09.12.557371v1">Previously in preprint</a>)<br><br><a href="https://www.biorxiv.org/content/10.1101/2023.12.12.571160v2">Non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2024.03.13.584735v1">Non-primate</a> <em>(MERS vaccine developed on the same platform as GBP511.)</em></td><td><em>(See “GBP511” above in this table.)</em></td></tr><tr><td>University of Wisconsin-Madison (PanCorVac)<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Protein subunit<br><br><em>All</em></td><td><a href="https://www.nature.com/articles/s42003-021-02128-8">Non-primate</a><br><br><a href="https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00523-0/fulltext">Non-primate</a><br><br><a href="https://www.researchsquare.com/article/rs-3088907/v1">Non-primate</a><br><br><a href="https://www.researchsquare.com/article/rs-4177301/v1">Non-primate</a><br></td><td></td></tr><tr><td>VBI Vaccines<br><em>Canada</em><br><br><em>VBI-2901</em></td><td>eVLP<br><br><em>All</em></td><td><a href="https://www.biorxiv.org/content/10.1101/2021.09.28.462109v1">Non-primate</a><br><br><a href="https://www.vbivaccines.com/press-releases/new-data-and-progress-of-vbi-2900-coronavirus-program/">Non-primate</a> (Press release)<br></td><td><a href="https://clinicaltrials.gov/ct2/show/NCT05548439">Phase 1 trial</a><br><em>(103 participants in Canada)</em><br>Began October 2022.<br>Fully recruited.<br>(<a href="https://cdn.who.int/media/docs/default-source/blue-print/dev_vbi-vaccines_whoconsultation_pan-sarbecovirus_28jan2022.pdf?sfvrsn=2b17ebb1_12">Further background info</a>.)<br><strong><a href="https://www.vbivaccines.com/press-releases/vbi-vaccines-pan-coronavirus-vaccine-candidate-vbi-2901-induced-broad-and-durable-protective-titers-against-variants-of-concern/">Results</a></strong> (press release only).<br><em>(101 participants)</em><br>Previously vaccinated people boosted with 2 low or high doses, or 1 high-dose. Limited data reported. Some signs of immune response to a range of coronaviruses, mostly lasting at least 5 months. No major safety concerns.</td></tr><tr><td>Walter Reed Army Institute of Research (WRAIR)<br><em>USA</em><br><br><em>SpFN/ALFQ</em></td><td>Protein subunit<br><br><em>Beta</em></td><td><a href="https://www.nature.com/articles/s41541-021-00392-7">Non-primate</a><br><br><a href="https://www.nature.com/articles/s41541-021-00414-4">Non-primate</a><br><br><a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01639-9">Non-primate</a> (incl RFN)<br><br><a href="https://www.nature.com/articles/s41541-023-00638-6">Non-primate</a><br><br><a href="https://www.science.org/doi/10.1126/scitranslmed.abi5735">Primate</a><br><br><a href="https://www.mdpi.com/2076-393X/10/5/717">Primate</a><br><br><a href="https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00128-3">Primate</a> (with J&J vax)</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT04784767">Phase 1 trial</a><br><em>(US)</em><br>Began April 2021, with 29 participants, including some on placebo.<br><strong><a href="https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00410-X/fulltext">Results</a></strong>.<br>Vaxed participants showed immune responses to several Covid variants and several sarbecoviruses, but no signs of response to MERS. </td></tr><tr><td>Walter Reed Army Institute of Research (WRAIR)<br><em>USA</em><br><br><em>RFN</em></td><td>Protein subunit<br><br><em>Beta</em></td><td><a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01639-9">Non-primate</a> (incl SpFN)<br><br><a href="https://www.pnas.org/doi/10.1073/pnas.2106433118">Primate</a></td><td></td></tr><tr><td>Yale University<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>mRNA<br><br><em>All</em></td><td><a href="https://www.nature.com/articles/s41467-022-30878-4">Non-primate</a><br><br><a href="https://www.biorxiv.org/content/10.1101/2022.05.07.491038v1">Non-primate</a></td><td></td></tr><tr><td>Yale University/Xanadu Bio<br><em>USA</em><br><br><em>(Unnamed)</em></td><td>Protein subunit, intranasal booster<br><br><em>Sarbeco</em></td><td><a href="https://www.science.org/doi/10.1126/science.abo2523">Non-primate</a></td><td></td></tr></tbody></table></figure> <div style="height:27px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <div style="height:22px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" id="definitions"></h2> <div style="height:31px" aria-hidden="true" class="wp-block-spacer"></div> <h4 class="wp-block-heading"><em>Addendum 4:</em> Definitions of vaccine types</h4> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <ul class="wp-block-list"> <li>Mucosal vaccines: These enter the body the way the virus does – through mucosal tissues. It’s hoped that provides defence against infection. They can be administered via different routes – squirts or drops in the nose, inhaled through the mouth through a nebulizer (similar to an asthma medication), or in tablet, capsule, or sublingual form.</li> <li>Pan-SARS-CoV-2 or “variant-proof” vaccines: These aim to provide protection against any variant of the coronavirus that causes Covid-19 – including future variants. I include vaccines that aim for greater durability in this group. </li> <li>Pancoronavirus can be targeted to: <ul class="wp-block-list"> <li>the “subgroup” the 2 SARS viruses came from (the sarbecovirus subgenus),</li> <li>coronaviruses from the next level up (the genus, betacoronavirus, which includes lethal diseases like MERS, as well as common cold viruses), or</li> <li>the whole coronavirus family – it has 4 genuses, including betacoronavirus and alphacoronavirus (with more common cold viruses).</li> </ul> </li> </ul> <p>I classify a vaccine as a pancoronavirus one when the developers are explicitly targeting coronaviruses more broadly than SARS-CoV-2, and have tested for signs of response to non-SARS-CoV-2 coronavirus(es) (or clearly plan to).</p> <div style="height:19px" aria-hidden="true" class="wp-block-spacer"></div> <p><em><a href="#contents">Back to contents</a></em></p> <div style="height:34px" aria-hidden="true" class="wp-block-spacer"></div> <p><em>You can keep up with my work at my newsletter, <a href="https://hildabastian.wordpress.com/">Living With Evidence</a>. And I’m active on Mastodon: <a href="https://mastodon.online/@hildabast">@hildabast@mastodon.online</a> </em></p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p>~~~~</p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p><em>For details on how I track Covid vaccine progress, see my <a href="https://absolutelymaybe.plos.org/2023/05/01/a-process-update-on-covid-vaccine-tracking/">background post</a>.</em> <em>Notes</em> <em>on my collection of studies are <a href="https://absolutelymaybe.plos.org/2022/01/26/boosters-and-mixed-schedules-covid-vaccines-at-the-2-year-mark-part-1/#collection">here</a>. The collection is in a public Zotero library you can dig into <a href="https://www.zotero.org/groups/2528572/covid-19_vaccine_results/library">here</a>.</em></p> <p><strong><em>Previous update posts on next generation Covid vaccines:</em></strong></p> <ol class="wp-block-list"> <li>Mucosal vaccines (<a href="https://absolutelymaybe.plos.org/2022/03/30/the-race-to-reduce-covid-19-transmission-an-update-on-66-intranasal-6-oral-vaccines/">March 2022</a>)</li> <li>Pan-SARS-Cov-2 and pancoronavirus (<a href="https://absolutelymaybe.plos.org/2022/07/09/front-runners-in-the-race-for-variant-proof-and-all-coronavirus-vaccines/">July 2022</a>)</li> <li>Mucosal vaccines (<a href="https://absolutelymaybe.plos.org/2022/07/31/next-generation-covid-vaccine-update-intranasal-other-mucosal-vaxes/">July 2022</a>)</li> <li>Mucosal vaccines (<a href="https://absolutelymaybe.plos.org/2022/09/29/intranasal-co-a-very-big-month-for-mucosal-covid-vaccines/">September 2022</a>)</li> <li>Mucosal vaccines (<a href="https://absolutelymaybe.plos.org/2023/04/21/progress-on-intranasal-oral-covid-vaccines-plus-a-us-government-funding-boost/">April 2023</a>)</li> <li>Pancoronavirus vaccines (<a href="https://absolutelymaybe.plos.org/2023/04/26/pancoronavirus-vaccines-update-lots-of-preclinical-results-another-trial-underway/">April 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/05/30/progress-on-next-generation-covid-vaccines-update-7/">May 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/06/29/this-months-progress-in-next-generation-covid-vaccines-update-8/">June 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/07/31/next-generation-covid-vaccines-update-no-9-major-new-hat-in-the-ring-plus-important-results/">July 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/08/25/more-next-generation-covid-vaccines-are-heading-into-clinical-trials-update-10/">August 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/09/30/a-bumper-news-month-for-next-generation-covid-vaccines-update-11/">September 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2023/11/30/advancing-past-early-trials-plus-shooting-for-lifelong-immunity-next-generation-covid-vax-update-12/">November 2023</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2024/01/11/a-major-first-next-generation-covid-vaccine-could-there-be-more-in-2024-update-13/">January 2024</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2024/02/23/picking-up-steam-next-generation-covid-vaccine-update-14/">February 2024</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2024/03/29/a-huge-boost-for-mucosal-covid-vax-development-next-generation-update-15/">March 2024</a>)</li> <li>Next generation (<a href="https://absolutelymaybe.plos.org/2024/04/30/mucosal-covid-vaccines-advancing-plus-a-new-type-of-vax-in-development-next-generation-update-16/">April 2024</a>)</li> </ol> <p>17. Next generation (<a href="https://absolutelymaybe.plos.org/2024/05/31/trial-results-for-longer-lasting-covid-vaccines-and-more-next-generation-update-17/">May 2024</a>)</p> <p>18. Next generation (<a href="https://absolutelymaybe.plos.org/2024/06/30/a-mini-surge-of-clinical-trials-and-advances-for-people-with-immunosuppression-nextgen-covid-vax-update-18/">June 2024</a>)</p> <p>19. Next generation (<a href="https://absolutelymaybe.plos.org/2024/07/31/more-signs-of-broad-protection-from-next-generation-covid-vaccines-update-19/">July 2024</a>)</p> <p id="block-12b463a2-9ae3-48f5-81eb-7684d46e71a9"><strong><em><a href="https://absolutelymaybe.plos.org/?post_tag=covid-19-vaccine-race"><br></a></em></strong><em><a href="https://absolutelymaybe.plos.org/?post_tag=covid-19-vaccine-race">All my Absolutely Maybe Covid-19 vaccine posts</a></em></p> <p id="block-b47c4fbc-dafa-4ed5-a2c3-947e9453cefc"><em><a href="https://absolutelymaybe.plos.org/?category=covid-19">All previous Covid-19 posts at Absolutely Maybe</a></em></p> <p id="block-0fe8fba6-9ca1-4ca2-b040-8819ba7a1b3a"><em>My posts</em> <em><a href="https://www.theatlantic.com/author/hilda-bastian/">at The Atlantic</a>, </em><a href="https://www.wired.com/author/hilda-bastian/"><em>at WIRED</em></a><em>, and debunking posts <a href="http://hildabastian.net/index.php/covid-19">at my personal website</a>.</em></p> <p id="block-8465f3ca-8753-4ee3-8d4b-7ce3b0b50d5a"><em>Disclosures: My interest in Covid-19 vaccine trials began as a person worried about the virus, as my son was immunocompromised: I have no financial or professional interest in the vaccines. I have worked for an institute of the NIH in the past, but not the one working on vaccines (<a href="https://www.niaid.nih.gov/">NIAID</a>). <a href="https://blogs.plos.org/absolutely-maybe/about-hilda-bastian/">More about me</a>.</em></p> <p id="block-6ebaea45-3de4-4762-9060-433e1161b62a"><em>The cartoon is my own <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/">(CC BY-NC-ND license)</a></em>. <em>(More cartoons at <a href="http://statistically-funny.blogspot.com/">Statistically Funny</a>.)</em></p> <div style="height:100px" aria-hidden="true" class="wp-block-spacer"></div> <p></p> </div> </article> <div class="single-recent-posts"> <div class="single-recent-posts__container"> <span class="single-recent-posts__label">Related Posts</span> <ul class="post-list post-list--grid post-list--non-elementor" id="recent-posts"> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://absolutelymaybe.plos.org/2024/10/31/strong-longterm-results-and-a-nextgen-anti-vax-campaign-covid-vax-update-22/" style="background-image: url(https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2024/10/We_dont_know_that-1024x340.jpg);" title="Strong Longterm Results – and a NextGen Anti-Vax Campaign (Covid Vax Update 22)"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Covid-19</span> <span class="post-list__post-title"> <a href="https://absolutelymaybe.plos.org/2024/10/31/strong-longterm-results-and-a-nextgen-anti-vax-campaign-covid-vax-update-22/">Strong Longterm Results – and a NextGen Anti-Vax Campaign (Covid Vax Update 22)</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 31, 2024</span> <span class="post-list__post-author">By <a href="https://absolutelymaybe.plos.org/author/hbastian/">Hilda Bastian</a></span> </div> <div class="post-list__post-excerpt"> <p>There’s a lot of big news in next generation Covid vaccine development this month, including clinical trial results for 2 vaccines. The…</p> </div> <a class="post-list__post-read-more" href="https://absolutelymaybe.plos.org/2024/10/31/strong-longterm-results-and-a-nextgen-anti-vax-campaign-covid-vax-update-22/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://absolutelymaybe.plos.org/2024/09/30/more-trial-results-and-more-pancoronavirus-vaccines-nextgen-covid-vax-update-21/" style="background-image: url(https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2023/04/Pancoronavirus.jpg);" title="More Trial Results and More Pancoronavirus Vaccines (NextGen Covid Vax Update 21)"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Covid-19</span> <span class="post-list__post-title"> <a href="https://absolutelymaybe.plos.org/2024/09/30/more-trial-results-and-more-pancoronavirus-vaccines-nextgen-covid-vax-update-21/">More Trial Results and More Pancoronavirus Vaccines (NextGen Covid Vax Update 21)</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">September 30, 2024</span> <span class="post-list__post-author">By <a href="https://absolutelymaybe.plos.org/author/hbastian/">Hilda Bastian</a></span> </div> <div class="post-list__post-excerpt"> <p>In this update there’s some news on the upcoming big trial in the US City of Hope/National Cancer Institute Covid vaccine for…</p> </div> <a class="post-list__post-read-more" href="https://absolutelymaybe.plos.org/2024/09/30/more-trial-results-and-more-pancoronavirus-vaccines-nextgen-covid-vax-update-21/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://absolutelymaybe.plos.org/2024/08/09/checking-in-on-pandemic-impact-on-women-in-science/" style="background-image: url(https://absolutelymaybe.plos.org/wp-content/uploads/sites/8/2023/06/Phew-1024x990.jpg);" title="Checking in on Pandemic Impact on Women in Science"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Covid-19</span> <span class="post-list__post-title"> <a href="https://absolutelymaybe.plos.org/2024/08/09/checking-in-on-pandemic-impact-on-women-in-science/">Checking in on Pandemic Impact on Women in Science</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">August 9, 2024</span> <span class="post-list__post-author">By <a href="https://absolutelymaybe.plos.org/author/hbastian/">Hilda Bastian</a></span> </div> <div class="post-list__post-excerpt"> <p>Before the pandemic, less than 30% of the world’s STEM researchers were women. When the lockdowns started, it didn’t take long for…</p> </div> <a class="post-list__post-read-more" href="https://absolutelymaybe.plos.org/2024/08/09/checking-in-on-pandemic-impact-on-women-in-science/">Read more</a> </div> </li> </ul> </div> </div> </main> </div> </div> <style type="text/css"> footer.app-footer { background-color: #050c2b; color: #ffffff; } footer.app-footer a, footer.app-footer label { color: #ffffff; } footer.app-footer input[type=text], footer.app-footer input[type=email] { background-color: #050c2b; border-color: #ffffff; color: #ffffff; } </style> <footer class="app-footer"> <div class="app-footer__container container"> <div class="app-footer__col app-footer__branding"> <a class="app-footer__brand" href="https://absolutelymaybe.plos.org/"> <img class="app-footer__logo" src="https://absolutelymaybe.plos.org/wp-content/uploads/2019/12/logo-white.svg" alt="Absolutely Maybe logo" /> </a> <ul class="social-media-links app-footer__social-media-links"> <li class="social-media-links__item social-media-links__item--twitter"> <a class="social-media-links__link" href="https://twitter.com/plos"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="twitter-icon-title"> <title id="twitter-icon-title">X (former Twitter)</title> <style type="text/css">.svg-twitter-fill{fill: #ffffff;}</style> <path class="svg-twitter-fill" d="M11.7,8.6L18.2,1h-1.6L11,7.6L6.4,1H1.2l6.9,10l-6.9,8h1.6l6-7l4.8,7h5.2L11.7,8.6L11.7,8.6z M9.5,11.1l-0.7-1L3.3,2.2h2.4l4.5,6.4l0.7,1l5.8,8.3h-2.4L9.5,11.1L9.5,11.1z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--facebook"> <a class="social-media-links__link" href="https://www.facebook.com/PLoS.org"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="facebook-icon-title"> <title id="facebook-icon-title">Facebook</title> <style type="text/css">.svg-facebook-fill{fill: #ffffff;}</style> <path class="svg-facebook-fill" d="M19.5 1.5v16.6c0 0.6-0.5 1.2-1.2 1.2h-4.8v-7.4h2.4l0.4-2.7h-2.8V7.1c0-0.8 0.4-1.2 1.2-1.2h1.8V3.4c0 0-0.8-0.1-1.9-0.1 -2.6 0-3.9 1.4-3.9 3.6v2.4H8.3v2.7h2.4v7.4h-9c-0.6 0-1.2-0.5-1.2-1.2V1.5c0-0.6 0.5-1.2 1.2-1.2h16.6C19 0.3 19.5 0.9 19.5 1.5z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--linkedin"> <a class="social-media-links__link" href="https://www.linkedin.com/company/public-library-of-science"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="linkedin-icon-title"> <title id="linkedin-icon-title">Linkedin</title> <style type="text/css">.svg-linkedin-fill{fill: #ffffff;}</style> <path class="svg-linkedin-fill" d="M2.9 5.1L2.9 5.1c-1.4 0-2.4-1-2.4-2.2 0-1.2 0.9-2.2 2.4-2.2 1.4 0 2.3 0.9 2.4 2.2C5.2 4.1 4.3 5.1 2.9 5.1zM4.9 7.1v12.3h-4V7.1H4.9zM11.2 19.3h-4V9.8c0 0-0.1-2.4-0.1-2.8h3.9l0.1 1.7c0.8-1.2 2-2.1 3.6-2.1 2.8 0 4.8 2 4.8 5.5v7.1h-4v-6.7c0-2-1-2.8-2.2-2.8 -1.2 0-2.2 0.8-2.2 2.4V19.3z"/> </svg> </a> </li> </ul> <span class="app-footer__info-text">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, and is based in California, US</span> </div> <div class="app-footer__col app-footer__nav"> <div class="app-footer__nav-container"> <div class="menu-footer-navigation-container"><ul id="menu-footer-navigation" class="app-header__footer-nav"><li id="menu-item-1680" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1680"><a href="https://plos.org/">Home</a></li> <li id="menu-item-309" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-309"><a href="https://plos.org/resources/">Resources</a></li> <li id="menu-item-308" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-308"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-383" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-383"><a href="https://plos.org/open-science/">Open Science</a></li> <li id="menu-item-412" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-412"><a href="https://plos.org/publish/">Publish with PLOS</a></li> <li id="menu-item-419" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-419"><a href="https://plos.org/about/">About PLOS</a></li> <li id="menu-item-34241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34241"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> <li id="menu-item-8117" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8117"><a href="https://plos.org/dei/">Diversity, Equity and Inclusion</a></li> <li id="menu-item-2817" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2817"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-1682" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1682"><a href="https://plos.org/about/contact/">Contact</a></li> <li id="menu-item-1683" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1683"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-1684" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1684"><a href="https://plos.org/careers/">Careers</a></li> <li id="menu-item-1685" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1685"><a href="https://plos.org/advertise/">Advertise</a></li> <li id="menu-item-35167" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-35167"><a href="https://plos.org/financial-overview/">Financial Overview</a></li> <li id="menu-item-25042" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-25042"><a href="https://plos.org/governance/">Governance</a></li> <li id="menu-item-1687" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-1687"><a rel="privacy-policy" href="https://plos.org/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-15441" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15441"><a href="https://plos.org/cookies-policy/">Cookie Policy</a></li> <li id="menu-item-1688" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1688"><a href="https://plos.org/terms-of-use/">Terms of Use</a></li> <li id="menu-item-7340" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7340"><a href="https://plos.org/payment-terms-and-conditions/">Payment Terms and Conditions</a></li> <li id="menu-item-1689" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1689"><a href="https://plos.org/text-and-data-mining/">Text & Data Mining</a></li> <li id="menu-item-11315" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11315"><a href="https://plos.org/terms-of-service/">Terms of Service</a></li> </ul></div> </div> </div> <div class="app-footer__col app-footer__rich-text"> <p><strong>News & Updates</strong></p> <form class="newsletter-signup" action="https://cl.exct.net/subscribe.aspx" name="subscribeForm" method="post"><input type="hidden" name="thx" value="https://www.plos.org/signup-success/"><input type="hidden" name="err" value="https://www.plos.org/signup-error/"><input type="hidden" name="SubAction" value="sub"><input type="hidden" name="MID" value="7207856"><input type="hidden" name="LID" value="5488"><input type="hidden" name="Source" value="WebCollect"><div class="newsletter-signup__input-container newsletter-signup__input-container--text-container"><label for="email-address">Email address</label><input type="email" id="email-address" name="Email Address"></div><div class="newsletter-signup__input-container newsletter-signup__input-container--checkbox-container"><span class="newsletter-signup__disclaimer">PLOS will use your email address to provide news and updates. You can find out more about how PLOS processes your data by reading our <a href="https://plos.org/privacy-policy/">Privacy Policy</a>. You can unsubscribe at any time by clicking the unsubscribe link in our emails or by contacting us at privacy@plos.org.</span></div><div class="newsletter-signup__input-container newsletter-signup__input-container--submit-container"><small class="newsletter-signup__validation-message">All fields are required, please check your entry and try again.</small><input type="submit" value="Submit"></div></form> </div> </div> </footer> <a class="back-to-top" id="back-to-top" href="#top"><span class="screen-reader-text">Back to top</span></a>  <script> /*! For license information please see body.js.LICENSE.txt */ (()=>{var e={490:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}t.Z=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(682)),i=u(n(628));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.Z=function(e){var t,n,r=e.dispatcher,u=(t=(0,a.useState)(!l.default.hasInteracted()),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),s=u[0],f=u[1];return r&&(0,a.useEffect)((function(){return r.sub("open",(function(){return f(!0)}))}),[]),a.default.createElement("div",{className:"cookie-consent"},a.default.createElement(o.default,{show:s}),a.default.createElement(i.default,{close:function(){f(!1)},show:s}))}},682:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=n(357),l=o(n(188));function o(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.show;return r.default.createElement(a.CSSTransition,{in:t,timeout:200,classNames:{enter:l.default.fadeInEnter,enterActive:l.default.fadeInEnterActive,exit:l.default.fadeInExit,exitActive:l.default.fadeInExitActive},unmountOnExit:!0},r.default.createElement("div",{className:l.default.overlay,role:"presentation"}))}},980:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0,t.default="data:image/svg+xml;charset=utf-8;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg enable-background="new 0 0 944 620" version="1.1" viewBox="0 0 944 620" xml:space="preserve" xmlns="http://www.w3.org/2000/svg">
<style type="text/css">
  .st0{fill:#F63C3D;}
  .st1{fill:#17BAFA;}
  .st2{opacity:0.93;}
  .st3{fill:#18335A;}
  .st4{fill:#D2DA20;}
  .st5{opacity:0.83;}
  .st6{fill:#007165;}
</style>
<path class="st0" d="m558.68 69.77c2.45-2.8 5.82-5.98 10.89-6.67 3.77-0.52 7.15 0.04 9.97 2.66 8.02 7.42 16.31 14.57 23.95 22.37 17.3 17.66 33.04 36.73 48.18 56.28 14.36 18.54 27.69 37.85 40.26 57.7 3.72 5.88 7.51 11.72 11.2 17.62 3.4 5.44 6.75 10.91 10.04 16.41 3.31 5.52 6.52 11.1 9.77 16.66 3 5.12 6.12 10.17 8.96 15.38 4.47 8.2 8.81 16.46 13.07 24.78 3.13 6.12 6.07 12.34 9.05 18.54 3.75 7.81 7.66 15.55 11.12 23.49 3.36 7.72 6.33 15.62 9.31 23.51 2.89 7.66 5.65 15.37 8.32 23.11 0.74 2.16 0.85 4.54 1.46 6.76 1.78 6.5 4.07 12.88 5.43 19.48 1.9 9.21 3.18 18.55 4.63 27.86 0.57 3.63 0.94 7.31 1.26 10.98 0.06 0.72-0.54 1.51-0.84 2.27-0.64-0.6-1.7-1.09-1.86-1.81-1.77-7.92-2.97-16-5.16-23.78-3.17-11.23-6.68-22.38-10.69-33.32-3.75-10.23-8.06-20.27-12.64-30.14-4.69-10.1-9.82-20.01-15.11-29.8-5.29-9.8-10.81-19.47-16.58-28.98-6.61-10.9-13.43-21.68-20.49-32.28-9.59-14.43-19.33-28.76-29.31-42.91-8.46-12-17.17-23.83-26.09-35.47-9.8-12.78-19.77-25.45-30.07-37.83-9.11-10.95-18.56-21.63-28.25-32.05-9.3-9.98-19.07-19.52-28.72-29.17-3.59-3.59-7.57-6.79-11.11-10.43-3.55-3.66-3.52-5.99 0.05-11.22z"/>
<path class="st1" d="m733.08 66.49c3.63-0.83 8.23-1.42 12.74 0.99 3.36 1.8 5.76 4.23 6.51 8.01 2.13 10.72 4.65 21.37 6.26 32.17 3.64 24.45 5.19 49.13 5.97 73.85 0.74 23.44 0.2 46.9-1.28 70.34-0.44 6.95-0.8 13.9-1.28 20.84-0.44 6.4-0.94 12.79-1.5 19.18-0.57 6.41-1.24 12.81-1.87 19.22-0.58 5.9-1.01 11.82-1.77 17.71-1.2 9.26-2.53 18.5-3.96 27.73-1.05 6.79-2.33 13.55-3.56 20.32-1.55 8.52-2.93 17.08-4.79 25.54-1.81 8.22-4.04 16.36-6.26 24.5-2.15 7.9-4.45 15.76-6.83 23.59-0.66 2.18-1.98 4.18-2.79 6.33-2.37 6.31-4.27 12.82-7.04 18.95-3.87 8.57-8.32 16.89-12.61 25.27-1.67 3.27-3.53 6.47-5.42 9.63-0.37 0.62-1.33 0.91-2.02 1.35-0.17-0.86-0.74-1.88-0.45-2.56 3.22-7.45 6.99-14.7 9.78-22.28 4.03-10.95 7.73-22.04 10.91-33.25 2.97-10.48 5.37-21.14 7.46-31.82 2.13-10.93 3.79-21.96 5.26-33 1.47-11.03 2.68-22.11 3.59-33.19 1.04-12.7 1.85-25.43 2.37-38.16 0.7-17.31 1.23-34.63 1.46-51.95 0.19-14.68 0.09-29.37-0.3-44.03-0.43-16.1-1.06-32.21-2.13-48.28-0.95-14.21-2.32-28.4-4.06-42.53-1.66-13.54-3.98-27-6.13-40.47-0.8-5.02-2.15-9.95-2.87-14.97-0.75-5.03 0.65-6.89 6.61-9.03z"/>
<g class="st2">
<path class="st3" d="m433.01 108.31c0.53-3.63 1.63-8.06 5.53-11.36 2.9-2.45 6.05-3.8 9.87-3.16 10.83 1.82 21.75 3.27 32.47 5.61 24.27 5.29 48.01 12.58 71.5 20.6 22.28 7.6 44.11 16.38 65.59 26.02 6.36 2.86 12.76 5.65 19.11 8.54 5.85 2.66 11.67 5.38 17.47 8.16 5.82 2.78 11.59 5.67 17.37 8.51 5.33 2.62 10.74 5.11 15.99 7.88 8.26 4.37 16.46 8.86 24.61 13.43 6 3.37 11.89 6.93 17.8 10.44 7.45 4.43 14.98 8.73 22.26 13.43 7.07 4.57 13.91 9.5 20.75 14.41 6.64 4.77 13.19 9.65 19.69 14.61 1.81 1.38 3.21 3.3 4.94 4.8 5.07 4.41 10.5 8.45 15.26 13.17 6.65 6.58 12.85 13.61 19.18 20.51 2.47 2.7 4.8 5.53 7.08 8.39 0.45 0.56 0.37 1.54 0.54 2.33-0.87-0.15-2.03 0.01-2.56-0.49-5.83-5.59-11.28-11.61-17.4-16.86-8.83-7.57-17.91-14.89-27.28-21.77-8.77-6.43-17.91-12.4-27.19-18.09-9.5-5.82-19.26-11.24-29.09-16.49s-19.79-10.27-29.87-15.03c-11.55-5.45-23.21-10.68-34.98-15.65-16-6.76-32.08-13.36-48.26-19.69-13.71-5.36-27.54-10.45-41.46-15.27-15.28-5.29-30.63-10.4-46.1-15.09-13.69-4.15-27.51-7.9-41.4-11.29-13.32-3.25-26.79-5.88-40.21-8.66-5-1.04-10.11-1.54-15.1-2.65-5.01-1.11-6.26-3.06-6.11-9.29z"/>
</g>
<path class="st4" d="m823.28 220.35c3.56 1.08 7.85 2.85 10.57 7.18 2.02 3.23 2.9 6.53 1.68 10.18-3.46 10.36-6.56 20.86-10.53 31.04-8.97 23.03-19.87 45.23-31.45 67.08-10.99 20.72-23.09 40.82-36.01 60.44-3.83 5.81-7.59 11.67-11.45 17.46-3.56 5.34-7.16 10.64-10.82 15.91-3.67 5.29-7.43 10.51-11.16 15.76-3.43 4.84-6.75 9.76-10.32 14.49-5.63 7.45-11.37 14.81-17.2 22.11-4.28 5.37-8.74 10.61-13.17 15.88-5.57 6.63-11.02 13.38-16.83 19.8-5.65 6.24-11.63 12.2-17.59 18.17-5.78 5.79-11.68 11.47-17.64 17.09-1.66 1.57-3.79 2.64-5.56 4.11-5.19 4.3-10.07 9.01-15.52 12.96-7.61 5.52-15.6 10.53-23.48 15.69-3.08 2.01-6.27 3.87-9.49 5.67-0.63 0.35-1.6 0.13-2.42 0.17 0.28-0.83 0.29-2 0.88-2.44 6.49-4.87 13.36-9.29 19.55-14.5 8.93-7.51 17.65-15.3 25.96-23.46 7.78-7.63 15.15-15.69 22.26-23.93 7.28-8.44 14.19-17.19 20.94-26.04s13.3-17.87 19.59-27.04c7.21-10.51 14.22-21.16 20.99-31.96 9.2-14.68 18.25-29.46 27.04-44.38 7.45-12.65 14.65-25.45 21.58-38.38 7.61-14.2 15.06-28.5 22.1-42.98 6.23-12.81 12.07-25.81 17.57-38.94 5.27-12.58 9.94-25.41 14.76-38.18 1.79-4.75 3.07-9.7 4.93-14.42 1.87-4.72 4.01-5.65 10.24-4.54z"/>
<g class="st5">
<path class="st6" d="m852.54 369.84c1.86 3.22 3.78 7.45 2.79 12.47-0.73 3.74-2.35 6.75-5.74 8.58-9.62 5.18-19.06 10.72-28.92 15.43-22.3 10.66-45.44 19.39-68.84 27.39-22.19 7.59-44.77 13.96-67.62 19.43-6.77 1.62-13.52 3.31-20.3 4.9-6.24 1.46-12.5 2.86-18.77 4.19-6.29 1.34-12.61 2.58-18.92 3.86-5.81 1.18-11.6 2.5-17.45 3.5-9.2 1.58-18.43 3.02-27.67 4.36-6.8 0.99-13.64 1.75-20.47 2.57-8.6 1.02-17.19 2.22-25.83 2.92-8.39 0.68-16.83 0.94-25.26 1.21-8.18 0.26-16.37 0.37-24.56 0.4-2.28 0.01-4.57-0.67-6.87-0.81-6.73-0.42-13.51-0.32-20.19-1.17-9.32-1.18-18.58-2.99-27.86-4.63-3.62-0.64-7.22-1.47-10.79-2.36-0.7-0.17-1.26-1-1.88-1.53 0.77-0.41 1.58-1.26 2.31-1.18 8.06 0.89 16.1 2.36 24.17 2.81 11.65 0.64 23.34 0.92 34.98 0.66 10.89-0.24 21.79-1.07 32.61-2.22 11.08-1.17 22.11-2.83 33.09-4.66s21.92-3.93 32.78-6.31c12.45-2.73 24.86-5.7 37.17-8.94 16.75-4.41 33.47-8.99 50.09-13.86 14.09-4.12 28.1-8.54 42-13.22 15.27-5.14 30.48-10.47 45.52-16.22 13.31-5.08 26.47-10.56 39.46-16.37 12.45-5.57 24.64-11.73 36.89-17.74 4.56-2.24 8.88-4.97 13.47-7.14 4.62-2.18 6.82-1.39 10.61 3.68z"/>
</g>
<circle class="st6" cx="809.09" cy="136.91" r="15.09"/>
<circle class="st3" cx="654.73" cy="35.79" r="15.09"/>
<circle class="st3" cx="486.18" cy="530.81" r="15.09"/>
<circle class="st3" cx="766.76" cy="496.13" r="15.09"/>
<circle class="st4" cx="624.54" cy="500.63" r="15.09"/>
<circle class="st4" cx="501.28" cy="50.88" r="15.09"/>
<circle class="st0" cx="858.6" cy="330.29" r="15.09"/>
<path class="st3" d="m56.96 240.33h67.34c40.02 0 64.9 22.69 64.9 57.1v0.49c0 38.31-30.74 58.32-68.32 58.32h-33.91v54.9h-30.01v-170.81zm64.91 88.82c22.69 0 36.84-12.69 36.84-30.5v-0.49c0-20.01-14.4-30.5-36.84-30.5h-34.9v61.49h34.9z"/>
<path class="st3" d="m219.95 240.33h30.01v143.47h89.79v27.33h-119.8v-170.8z"/>
<path class="st3" d="m352.69 326.22v-0.49c0-48.07 37.09-88.33 89.55-88.33s89.06 39.77 89.06 87.84v0.49c0 48.07-37.09 88.33-89.55 88.33s-89.06-39.77-89.06-87.84zm147.13 0v-0.49c0-33.18-24.16-60.51-58.07-60.51s-57.58 26.84-57.58 60.02v0.49c0 33.18 24.16 60.51 58.07 60.51 33.91 0.01 57.58-26.83 57.58-60.02z"/>
  <path class="st3" d="m554.96 386.25 18.06-21.47c16.35 14.15 32.94 22.2 53.92 22.2 18.54 0 30.26-8.78 30.26-21.47v-0.49c0-12.2-6.83-18.79-38.55-26.11-36.36-8.78-56.85-19.52-56.85-51v-0.49c0-29.28 24.4-49.53 58.32-49.53 24.89 0 44.65 7.56 61.98 21.47l-16.1 22.69c-15.37-11.47-30.74-17.57-46.36-17.57-17.57 0-27.82 9.03-27.82 20.25v0.49c0 13.18 7.81 19.03 40.75 26.84 36.11 8.78 54.66 21.72 54.66 50.02v0.49c0 31.96-25.13 51-61 51-26.13 0.01-50.77-9.02-71.27-27.32z"/>
</svg>"},905:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(413)),i=u(n(141));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,r=e.title,u=e.code,s=e.children,f=e.alwaysOn,d=void 0!==f&&f,p=(t=(0,a.useState)(!1),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),y=p[0],h=p[1],g=d?a.default.createElement("div",{className:o.default.alwaysOnMessage},"Always On"):a.default.createElement(i.default,{onClick:function(e){return function(e,t){"INPUT"===t.target.tagName&&l.default.customize(e,t.target.checked)}(u,e)},defaultChecked:l.default.hasConsented(u)}),m=function(){h(!y)};return a.default.createElement("div",{className:o.default.cookieType},a.default.createElement("div",{className:o.default.switchContainer},a.default.createElement("div",{role:"button",className:o.default.toggleExplanation,onClick:m,onKeyDown:m,tabIndex:0,"aria-label":"Toggle explanation of ".concat(r," Cookies.")},a.default.createElement("span",{className:o.default.toggleIcon},y?"-":"+"),a.default.createElement("strong",{className:o.default.toggleTitle},r)),a.default.createElement("div",{className:o.default.spacer}),g),!!y&&a.default.createElement("div",{className:o.default.explanationContainer},a.default.createElement("div",{className:o.default.toggleIcon}," "),s))}},628:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=s(n(294)),a=n(357),l=s(n(177)),o=s(n(905)),i=s(n(810)),u=s(n(980));function s(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.close,n=e.show;return r.default.createElement(a.CSSTransition,{in:n,timeout:200,classNames:{enter:i.default.slideOutEnter,enterActive:i.default.slideOutEnterActive,exit:i.default.slideOutExit,exitActive:i.default.slideOutExitActive},unmountOnExit:!0},r.default.createElement("div",{className:i.default.slideOut},r.default.createElement("div",{className:i.default.plosLogoWrapper},r.default.createElement("div",null,r.default.createElement("img",{alt:"PLOS Logo",className:i.default.plosLogo,src:u.default})),r.default.createElement("h3",{className:i.default.heading},"Cookie Preference Center")),r.default.createElement("p",{className:i.default.text},"Our website uses different types of cookies. Optional cookies will only be set with your consent and you may withdraw this consent at any time. Below you can learn more about the types of cookies PLOS uses and register your cookie preferences."),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.accept(),t()}},"Accept All Cookies")),r.default.createElement("div",null,r.default.createElement("h3",{className:i.default.customizeHeading},"Customize Your Cookie Preference"),r.default.createElement(o.default,{title:"Strictly Necessary",alwaysOn:!0},"These cookies are necessary to operating the PLOS website. They provide site security, help balance load on our servers, and other essential functions."),r.default.createElement(o.default,{title:"Functional",code:"functionality"},"These cookies and other technologies provide useful site functionality such as remembering your site preferences, allowing you to navigate the PLOS site more efficiently."),r.default.createElement(o.default,{title:"Performance and Analytics",code:"analytics"},"These cookies and other technologies analyze how the PLOS website is accessed, used, and performing in order to maintain and continually improve user experience on the site."),r.default.createElement(o.default,{title:"Marketing",code:"advertising"},"These cookies deliver contextual advertisements on the PLOS site and help third-parties serve you targeted advertisements based on your browsing history.")),r.default.createElement("div",{className:i.default.spacer}),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.hasInteracted()||l.default.reject(),t()}},"Save Selected Preferences and Close")),r.default.createElement("a",{className:i.default.underline,href:"https://plos.org/cookies-policy",target:"_blank",rel:"noreferrer"},"For more information about the cookies and other technologies used by us, please read our Cookie Policy.")))}},141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=o(n(403)),l=o(n(454));function o(e){return e&&e.__esModule?e:{default:e}}function i(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,o=e.defaultChecked,u=e.onClick,s=e.disabled,c=void 0!==s&&s,f="switch"+(t=r.default.useState((0,a.default)()),n=1,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return i(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?i(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}())[0];return r.default.createElement("div",{className:l.default.switch},r.default.createElement("input",{className:l.default.input,disabled:c,id:f,type:"checkbox",defaultChecked:o,onChange:u}),r.default.createElement("label",{className:l.default.paddle,htmlFor:f},r.default.createElement("span",{className:l.default.active},"On"),r.default.createElement("span",{className:l.default.inactive},"Off")))}},403:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var n=0;t.default=function(){return n++}},773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(808))&&r.__esModule?r:{default:r},l=n(773);function o(e){return Object.assign({},...l.VALID_PURPOSES.map((t=>({[t]:e}))))}var i={get:function(){try{const e=JSON.parse(a.default.get(l.COOKIE_KEY));return e?!0===e?o(!0):e:o(!1)}catch(e){return o(!1)}},isSet:function(){return void 0!==a.default.get(l.COOKIE_KEY)},remove:function(){a.default.remove(l.COOKIE_KEY)},set:function(e){const t=window.location.hostname;a.default.set(l.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:l.RECONSENT_INTERVAL})}};t.default=i},177:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(502))&&r.__esModule?r:{default:r},l=n(773);function o(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,a.default.get())}var i={accept:function(){a.default.set(!0),o()},customize:function(e,t){a.default.set(Object.assign(a.default.get(),{[e]:t})),o()},hasConsented:function(e){if(!l.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+l.VALID_PURPOSES.toString());return a.default.get()[e]},hasInteracted:function(){return a.default.isSet()},reject:function(){a.default.set(!1),o()},reset:function(){a.default.remove()},VALID_PURPOSES:l.VALID_PURPOSES};t.default=i},151:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._2w1UwhvJHT_qwQKK4m2Mtf{background-color:#333;bottom:0;left:0;position:fixed;right:0;opacity:.5;top:0;z-index:1}._1y82vgULYYDGyWdjHVia6r{opacity:0}._367_oaFBsPkUkmVR1bGNYm{opacity:.5;transition:opacity 200ms}._2dI2_nwyJPeiTPjhARwALQ{opacity:.5}._2f5ts8uYo0Bpq4XYl7aiJU{opacity:0;transition:opacity 200ms}",""]),a.locals={overlay:"_2w1UwhvJHT_qwQKK4m2Mtf",fadeInEnter:"_1y82vgULYYDGyWdjHVia6r",fadeInEnterActive:"_367_oaFBsPkUkmVR1bGNYm",fadeInExit:"_2dI2_nwyJPeiTPjhARwALQ",fadeInExitActive:"_2f5ts8uYo0Bpq4XYl7aiJU"};const l=a},148:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._3A__ku4NC-f73WZK-2WSLx{flex-grow:1}._2CmoA8p3s0vKIspSCosl9G{cursor:pointer;display:flex;font-weight:bold}._3UCm4aXUK13m4R_iCXSEyn{display:inline-block;flex:0 0 1em}._2qXwuhqwMHjam4FPIz7LCs{flex-shrink:0}.l1QQ8S-nhYCUogSWaE0yF,.s4KCa9TCuz7L8vB3Y0Zto{align-items:center;display:flex;margin-bottom:4px;min-height:32px}._1FFdDFwCKdHcKsmbvSZf6_{margin-right:2px;font-style:italic}",""]),a.locals={spacer:"_3A__ku4NC-f73WZK-2WSLx",toggleExplanation:"_2CmoA8p3s0vKIspSCosl9G",toggleIcon:"_3UCm4aXUK13m4R_iCXSEyn",toggleTitle:"_2qXwuhqwMHjam4FPIz7LCs",switchContainer:"l1QQ8S-nhYCUogSWaE0yF",explanationContainer:"s4KCa9TCuz7L8vB3Y0Zto",alwaysOnMessage:"_1FFdDFwCKdHcKsmbvSZf6_"};const l=a},908:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._1tEo1q2cUK9NIysoJrVPWB{background-color:#fff;bottom:0;color:#1c2e5e;display:flex;flex-direction:column;font-size:14px;max-height:100%;max-width:95%;min-width:320px;padding:16px;position:fixed;overflow-y:auto;top:0;width:25%;z-index:2}.T1Y5lu3DhJYBpNej0XUqn{left:-100vw}._1LboXNkeCnS8lrcYjApaZG{left:0;transition:left 200ms}.M0lj2upZTiu02JJDGvGB{left:0}._3MASX-v6vhk8saSO9VmJ6U{left:-100vw;transition:left 200ms}._28VwqbFjT3AsGRoYLhfgjy{color:#1c2e5e;font-size:20px;font-weight:bold}.xI7u62vIvKFhmZX2xirm- ._28VwqbFjT3AsGRoYLhfgjy{margin-bottom:0}._1rHZW01Wf74DBd08dYWESO{height:40px;margin-right:5px;width:auto}.xI7u62vIvKFhmZX2xirm-{align-items:center;display:flex;flex-direction:row}._369CBb-mfyjgJZcxE85upM{font-size:14px}._1u4ynVnXwZaZEsjTHxtV0v{flex-grow:1}._29PzLWpueUEyRToV1hjZjn{display:flex;flex-wrap:wrap;justify-content:space-around;margin-top:16px;margin-bottom:24px}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn{flex-direction:column}}._29PzLWpueUEyRToV1hjZjn button{background-color:#1c2e5e;border:1px solid #000;border-radius:5px;color:#fff;cursor:pointer;font-size:14px;font-weight:bold;flex-grow:1;padding:8px;white-space:nowrap}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn button~button{margin-top:12px}}@media(min-width: 1501px){._29PzLWpueUEyRToV1hjZjn button~button{margin-left:12px}}.ITkiffnwKKM34XaIHLjB_{color:#1c2e5e;font-size:14px;font-weight:bold}._38RYPxeKGNUF74SufFb2Cn{text-decoration:underline;text-decoration-color:blue}",""]),a.locals={slideOut:"_1tEo1q2cUK9NIysoJrVPWB",slideOutEnter:"T1Y5lu3DhJYBpNej0XUqn",slideOutEnterActive:"_1LboXNkeCnS8lrcYjApaZG",slideOutExit:"M0lj2upZTiu02JJDGvGB",slideOutExitActive:"_3MASX-v6vhk8saSO9VmJ6U",heading:"_28VwqbFjT3AsGRoYLhfgjy",plosLogoWrapper:"xI7u62vIvKFhmZX2xirm-",plosLogo:"_1rHZW01Wf74DBd08dYWESO",text:"_369CBb-mfyjgJZcxE85upM",spacer:"_1u4ynVnXwZaZEsjTHxtV0v",buttonContainer:"_29PzLWpueUEyRToV1hjZjn",customizeHeading:"ITkiffnwKKM34XaIHLjB_",underline:"_38RYPxeKGNUF74SufFb2Cn"};const l=a},174:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,'._2ynah8Lgqwdr9aOADyNLnm{color:#fefefe;font-size:12px;font-weight:bold;height:32px;outline:0;position:relative;user-select:none}._16DjzBVfVPFmQVgTgNlqAD{margin-bottom:0;opacity:0;position:absolute}._2o1hzYk15DlFY9KaHai3O2{background:#cacaca;border-radius:16px;color:inherit;cursor:pointer;display:block;font-weight:inherit;height:32px;position:relative;transition:all .25s ease-out;width:64px}._2o1hzYk15DlFY9KaHai3O2::after{background:#fefefe;border-radius:14px;content:"";display:block;height:24px;left:4px;position:absolute;transform:translate3d(0, 0, 0);transition:all .25s ease-out;top:4px;width:24px}input:checked~._2o1hzYk15DlFY9KaHai3O2::after{left:36px}input:checked~._2o1hzYk15DlFY9KaHai3O2{background:#32a960}._3vFoGG1De0BqwBpqyyWHgM{display:none;left:10%}input:checked+label>._3vFoGG1De0BqwBpqyyWHgM{display:block}._3vFoGG1De0BqwBpqyyWHgM,.KUzu_RflxRcodvteC94f5{position:absolute;transform:translateY(-50%);top:50%}.KUzu_RflxRcodvteC94f5{right:15%}input:checked+label>.KUzu_RflxRcodvteC94f5{display:none}',""]),a.locals={switch:"_2ynah8Lgqwdr9aOADyNLnm",input:"_16DjzBVfVPFmQVgTgNlqAD",paddle:"_2o1hzYk15DlFY9KaHai3O2",active:"_3vFoGG1De0BqwBpqyyWHgM",inactive:"KUzu_RflxRcodvteC94f5"};const l=a},645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n=e(t);return t[2]?"@media ".concat(t[2]," {").concat(n,"}"):n})).join("")},t.i=function(e,n,r){"string"==typeof e&&(e=[[null,e,""]]);var a={};if(r)for(var l=0;l<this.length;l++){var o=this[l][0];null!=o&&(a[o]=!0)}for(var i=0;i<e.length;i++){var u=[].concat(e[i]);r&&a[u[0]]||(n&&(u[2]?u[2]="".concat(n," and ").concat(u[2]):u[2]=n),t.push(u))}},t}},808:(e,t,n)=>{var r,a,l;void 0===(a="function"==typeof(r=l=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var r in n)t[r]=n[r]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(r){function a(){}function l(t,n,l){if("undefined"!=typeof document){"number"==typeof(l=e({path:"/"},a.defaults,l)).expires&&(l.expires=new Date(1*new Date+864e5*l.expires)),l.expires=l.expires?l.expires.toUTCString():"";try{var o=JSON.stringify(n);/^[\{\[]/.test(o)&&(n=o)}catch(e){}n=r.write?r.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var i="";for(var u in l)l[u]&&(i+="; "+u,!0!==l[u]&&(i+="="+l[u].split(";")[0]));return document.cookie=t+"="+n+i}}function o(e,n){if("undefined"!=typeof document){for(var a={},l=document.cookie?document.cookie.split("; "):[],o=0;o<l.length;o++){var i=l[o].split("="),u=i.slice(1).join("=");n||'"'!==u.charAt(0)||(u=u.slice(1,-1));try{var s=t(i[0]);if(u=(r.read||r)(u,s)||t(u),n)try{u=JSON.parse(u)}catch(e){}if(a[s]=u,e===s)break}catch(e){}}return e?a[e]:a}}return a.set=l,a.get=function(e){return o(e,!1)},a.getJSON=function(e){return o(e,!0)},a.remove=function(t,n){l(t,"",e(n,{expires:-1}))},a.defaults={},a.withConverter=n,a}((function(){}))})?r.call(t,n,t,e):r)||(e.exports=a),e.exports=l()},418:e=>{"use strict";var t=Object.getOwnPropertySymbols,n=Object.prototype.hasOwnProperty,r=Object.prototype.propertyIsEnumerable;function a(e){if(null==e)throw new TypeError("Object.assign cannot be called with null or undefined");return Object(e)}e.exports=function(){try{if(!Object.assign)return!1;var e=new String("abc");if(e[5]="de","5"===Object.getOwnPropertyNames(e)[0])return!1;for(var t={},n=0;n<10;n++)t["_"+String.fromCharCode(n)]=n;if("0123456789"!==Object.getOwnPropertyNames(t).map((function(e){return t[e]})).join(""))return!1;var r={};return"abcdefghijklmnopqrst".split("").forEach((function(e){r[e]=e})),"abcdefghijklmnopqrst"===Object.keys(Object.assign({},r)).join("")}catch(e){return!1}}()?Object.assign:function(e,l){for(var o,i,u=a(e),s=1;s<arguments.length;s++){for(var c in o=Object(arguments[s]))n.call(o,c)&&(u[c]=o[c]);if(t){i=t(o);for(var f=0;f<i.length;f++)r.call(o,i[f])&&(u[i[f]]=o[i[f]])}}return u}},448:(e,t,n)=>{"use strict";var r=n(294),a=n(418),l=n(840);function o(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}if(!r)throw Error(o(227));var i=new Set,u={};function s(e,t){c(e,t),c(e+"Capture",t)}function c(e,t){for(u[e]=t,e=0;e<t.length;e++)i.add(t[e])}var f=!("undefined"==typeof window||void 0===window.document||void 0===window.document.createElement),d=/^[:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD][:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD\-.0-9\u00B7\u0300-\u036F\u203F-\u2040]*$/,p=Object.prototype.hasOwnProperty,y={},h={};function g(e,t,n,r,a,l,o){this.acceptsBooleans=2===t||3===t||4===t,this.attributeName=r,this.attributeNamespace=a,this.mustUseProperty=n,this.propertyName=e,this.type=t,this.sanitizeURL=l,this.removeEmptyString=o}var m={};"children dangerouslySetInnerHTML defaultValue defaultChecked innerHTML suppressContentEditableWarning suppressHydrationWarning style".split(" ").forEach((function(e){m[e]=new g(e,0,!1,e,null,!1,!1)})),[["acceptCharset","accept-charset"],["className","class"],["htmlFor","for"],["httpEquiv","http-equiv"]].forEach((function(e){var t=e[0];m[t]=new g(t,1,!1,e[1],null,!1,!1)})),["contentEditable","draggable","spellCheck","value"].forEach((function(e){m[e]=new g(e,2,!1,e.toLowerCase(),null,!1,!1)})),["autoReverse","externalResourcesRequired","focusable","preserveAlpha"].forEach((function(e){m[e]=new g(e,2,!1,e,null,!1,!1)})),"allowFullScreen async autoFocus autoPlay controls default defer disabled disablePictureInPicture disableRemotePlayback formNoValidate hidden loop noModule noValidate open playsInline readOnly required reversed scoped seamless itemScope".split(" ").forEach((function(e){m[e]=new g(e,3,!1,e.toLowerCase(),null,!1,!1)})),["checked","multiple","muted","selected"].forEach((function(e){m[e]=new g(e,3,!0,e,null,!1,!1)})),["capture","download"].forEach((function(e){m[e]=new g(e,4,!1,e,null,!1,!1)})),["cols","rows","size","span"].forEach((function(e){m[e]=new g(e,6,!1,e,null,!1,!1)})),["rowSpan","start"].forEach((function(e){m[e]=new g(e,5,!1,e.toLowerCase(),null,!1,!1)}));var v=/[\-:]([a-z])/g;function b(e){return e[1].toUpperCase()}function M(e,t,n,r){var a=m.hasOwnProperty(t)?m[t]:null;(null!==a?0===a.type:!r&&2<t.length&&("o"===t[0]||"O"===t[0])&&("n"===t[1]||"N"===t[1]))||(function(e,t,n,r){if(null==t||function(e,t,n,r){if(null!==n&&0===n.type)return!1;switch(typeof t){case"function":case"symbol":return!0;case"boolean":return!r&&(null!==n?!n.acceptsBooleans:"data-"!==(e=e.toLowerCase().slice(0,5))&&"aria-"!==e);default:return!1}}(e,t,n,r))return!0;if(r)return!1;if(null!==n)switch(n.type){case 3:return!t;case 4:return!1===t;case 5:return isNaN(t);case 6:return isNaN(t)||1>t}return!1}(t,n,a,r)&&(n=null),r||null===a?function(e){return!!p.call(h,e)||!p.call(y,e)&&(d.test(e)?h[e]=!0:(y[e]=!0,!1))}(t)&&(null===n?e.removeAttribute(t):e.setAttribute(t,""+n)):a.mustUseProperty?e[a.propertyName]=null===n?3!==a.type&&"":n:(t=a.attributeName,r=a.attributeNamespace,null===n?e.removeAttribute(t):(n=3===(a=a.type)||4===a&&!0===n?"":""+n,r?e.setAttributeNS(r,t,n):e.setAttribute(t,n))))}"accent-height alignment-baseline arabic-form baseline-shift cap-height clip-path clip-rule color-interpolation color-interpolation-filters color-profile color-rendering dominant-baseline enable-background fill-opacity fill-rule flood-color flood-opacity font-family font-size font-size-adjust font-stretch font-style font-variant font-weight glyph-name glyph-orientation-horizontal glyph-orientation-vertical horiz-adv-x horiz-origin-x image-rendering letter-spacing lighting-color marker-end marker-mid marker-start overline-position overline-thickness paint-order panose-1 pointer-events rendering-intent shape-rendering stop-color stop-opacity strikethrough-position strikethrough-thickness stroke-dasharray stroke-dashoffset stroke-linecap stroke-linejoin stroke-miterlimit stroke-opacity stroke-width text-anchor text-decoration text-rendering underline-position underline-thickness unicode-bidi unicode-range units-per-em v-alphabetic v-hanging v-ideographic v-mathematical vector-effect vert-adv-y vert-origin-x vert-origin-y word-spacing writing-mode xmlns:xlink x-height".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,null,!1,!1)})),"xlink:actuate xlink:arcrole xlink:role xlink:show xlink:title xlink:type".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/1999/xlink",!1,!1)})),["xml:base","xml:lang","xml:space"].forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/XML/1998/namespace",!1,!1)})),["tabIndex","crossOrigin"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!1,!1)})),m.xlinkHref=new g("xlinkHref",1,!1,"xlink:href","http://www.w3.org/1999/xlink",!0,!1),["src","href","action","formAction"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!0,!0)}));var E=r.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED,L=60103,N=60106,w=60107,S=60108,x=60114,k=60109,j=60110,T=60112,C=60113,I=60120,D=60115,O=60116,z=60121,A=60128,_=60129,P=60130,U=60131;if("function"==typeof Symbol&&Symbol.for){var Y=Symbol.for;L=Y("react.element"),N=Y("react.portal"),w=Y("react.fragment"),S=Y("react.strict_mode"),x=Y("react.profiler"),k=Y("react.provider"),j=Y("react.context"),T=Y("react.forward_ref"),C=Y("react.suspense"),I=Y("react.suspense_list"),D=Y("react.memo"),O=Y("react.lazy"),z=Y("react.block"),Y("react.scope"),A=Y("react.opaque.id"),_=Y("react.debug_trace_mode"),P=Y("react.offscreen"),U=Y("react.legacy_hidden")}var Q,R="function"==typeof Symbol&&Symbol.iterator;function F(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=R&&e[R]||e["@iterator"])?e:null}function V(e){if(void 0===Q)try{throw Error()}catch(e){var t=e.stack.trim().match(/\n( *(at )?)/);Q=t&&t[1]||""}return"\n"+Q+e}var B=!1;function W(e,t){if(!e||B)return"";B=!0;var n=Error.prepareStackTrace;Error.prepareStackTrace=void 0;try{if(t)if(t=function(){throw Error()},Object.defineProperty(t.prototype,"props",{set:function(){throw Error()}}),"object"==typeof Reflect&&Reflect.construct){try{Reflect.construct(t,[])}catch(e){var r=e}Reflect.construct(e,[],t)}else{try{t.call()}catch(e){r=e}e.call(t.prototype)}else{try{throw Error()}catch(e){r=e}e()}}catch(e){if(e&&r&&"string"==typeof e.stack){for(var a=e.stack.split("\n"),l=r.stack.split("\n"),o=a.length-1,i=l.length-1;1<=o&&0<=i&&a[o]!==l[i];)i--;for(;1<=o&&0<=i;o--,i--)if(a[o]!==l[i]){if(1!==o||1!==i)do{if(o--,0>--i||a[o]!==l[i])return"\n"+a[o].replace(" at new "," at ")}while(1<=o&&0<=i);break}}}finally{B=!1,Error.prepareStackTrace=n}return(e=e?e.displayName||e.name:"")?V(e):""}function H(e){switch(e.tag){case 5:return V(e.type);case 16:return V("Lazy");case 13:return V("Suspense");case 19:return V("SuspenseList");case 0:case 2:case 15:return W(e.type,!1);case 11:return W(e.type.render,!1);case 22:return W(e.type._render,!1);case 1:return W(e.type,!0);default:return""}}function K(e){if(null==e)return null;if("function"==typeof e)return e.displayName||e.name||null;if("string"==typeof e)return e;switch(e){case w:return"Fragment";case N:return"Portal";case x:return"Profiler";case S:return"StrictMode";case C:return"Suspense";case I:return"SuspenseList"}if("object"==typeof e)switch(e.$$typeof){case j:return(e.displayName||"Context")+".Consumer";case k:return(e._context.displayName||"Context")+".Provider";case T:var t=e.render;return t=t.displayName||t.name||"",e.displayName||(""!==t?"ForwardRef("+t+")":"ForwardRef");case D:return K(e.type);case z:return K(e._render);case O:t=e._payload,e=e._init;try{return K(e(t))}catch(e){}}return null}function G(e){switch(typeof e){case"boolean":case"number":case"object":case"string":case"undefined":return e;default:return""}}function $(e){var t=e.type;return(e=e.nodeName)&&"input"===e.toLowerCase()&&("checkbox"===t||"radio"===t)}function q(e){e._valueTracker||(e._valueTracker=function(e){var t=$(e)?"checked":"value",n=Object.getOwnPropertyDescriptor(e.constructor.prototype,t),r=""+e[t];if(!e.hasOwnProperty(t)&&void 0!==n&&"function"==typeof n.get&&"function"==typeof n.set){var a=n.get,l=n.set;return Object.defineProperty(e,t,{configurable:!0,get:function(){return a.call(this)},set:function(e){r=""+e,l.call(this,e)}}),Object.defineProperty(e,t,{enumerable:n.enumerable}),{getValue:function(){return r},setValue:function(e){r=""+e},stopTracking:function(){e._valueTracker=null,delete e[t]}}}}(e))}function Z(e){if(!e)return!1;var t=e._valueTracker;if(!t)return!0;var n=t.getValue(),r="";return e&&(r=$(e)?e.checked?"true":"false":e.value),(e=r)!==n&&(t.setValue(e),!0)}function X(e){if(void 0===(e=e||("undefined"!=typeof document?document:void 0)))return null;try{return e.activeElement||e.body}catch(t){return e.body}}function J(e,t){var n=t.checked;return a({},t,{defaultChecked:void 0,defaultValue:void 0,value:void 0,checked:null!=n?n:e._wrapperState.initialChecked})}function ee(e,t){var n=null==t.defaultValue?"":t.defaultValue,r=null!=t.checked?t.checked:t.defaultChecked;n=G(null!=t.value?t.value:n),e._wrapperState={initialChecked:r,initialValue:n,controlled:"checkbox"===t.type||"radio"===t.type?null!=t.checked:null!=t.value}}function te(e,t){null!=(t=t.checked)&&M(e,"checked",t,!1)}function ne(e,t){te(e,t);var n=G(t.value),r=t.type;if(null!=n)"number"===r?(0===n&&""===e.value||e.value!=n)&&(e.value=""+n):e.value!==""+n&&(e.value=""+n);else if("submit"===r||"reset"===r)return void e.removeAttribute("value");t.hasOwnProperty("value")?ae(e,t.type,n):t.hasOwnProperty("defaultValue")&&ae(e,t.type,G(t.defaultValue)),null==t.checked&&null!=t.defaultChecked&&(e.defaultChecked=!!t.defaultChecked)}function re(e,t,n){if(t.hasOwnProperty("value")||t.hasOwnProperty("defaultValue")){var r=t.type;if(!("submit"!==r&&"reset"!==r||void 0!==t.value&&null!==t.value))return;t=""+e._wrapperState.initialValue,n||t===e.value||(e.value=t),e.defaultValue=t}""!==(n=e.name)&&(e.name=""),e.defaultChecked=!!e._wrapperState.initialChecked,""!==n&&(e.name=n)}function ae(e,t,n){"number"===t&&X(e.ownerDocument)===e||(null==n?e.defaultValue=""+e._wrapperState.initialValue:e.defaultValue!==""+n&&(e.defaultValue=""+n))}function le(e,t){return e=a({children:void 0},t),(t=function(e){var t="";return r.Children.forEach(e,(function(e){null!=e&&(t+=e)})),t}(t.children))&&(e.children=t),e}function oe(e,t,n,r){if(e=e.options,t){t={};for(var a=0;a<n.length;a++)t["$"+n[a]]=!0;for(n=0;n<e.length;n++)a=t.hasOwnProperty("$"+e[n].value),e[n].selected!==a&&(e[n].selected=a),a&&r&&(e[n].defaultSelected=!0)}else{for(n=""+G(n),t=null,a=0;a<e.length;a++){if(e[a].value===n)return e[a].selected=!0,void(r&&(e[a].defaultSelected=!0));null!==t||e[a].disabled||(t=e[a])}null!==t&&(t.selected=!0)}}function ie(e,t){if(null!=t.dangerouslySetInnerHTML)throw Error(o(91));return a({},t,{value:void 0,defaultValue:void 0,children:""+e._wrapperState.initialValue})}function ue(e,t){var n=t.value;if(null==n){if(n=t.children,t=t.defaultValue,null!=n){if(null!=t)throw Error(o(92));if(Array.isArray(n)){if(!(1>=n.length))throw Error(o(93));n=n[0]}t=n}null==t&&(t=""),n=t}e._wrapperState={initialValue:G(n)}}function se(e,t){var n=G(t.value),r=G(t.defaultValue);null!=n&&((n=""+n)!==e.value&&(e.value=n),null==t.defaultValue&&e.defaultValue!==n&&(e.defaultValue=n)),null!=r&&(e.defaultValue=""+r)}function ce(e){var t=e.textContent;t===e._wrapperState.initialValue&&""!==t&&null!==t&&(e.value=t)}var fe="http://www.w3.org/1999/xhtml";function de(e){switch(e){case"svg":return"http://www.w3.org/2000/svg";case"math":return"http://www.w3.org/1998/Math/MathML";default:return"http://www.w3.org/1999/xhtml"}}function pe(e,t){return null==e||"http://www.w3.org/1999/xhtml"===e?de(t):"http://www.w3.org/2000/svg"===e&&"foreignObject"===t?"http://www.w3.org/1999/xhtml":e}var ye,he,ge=(he=function(e,t){if("http://www.w3.org/2000/svg"!==e.namespaceURI||"innerHTML"in e)e.innerHTML=t;else{for((ye=ye||document.createElement("div")).innerHTML="<svg>"+t.valueOf().toString()+"</svg>",t=ye.firstChild;e.firstChild;)e.removeChild(e.firstChild);for(;t.firstChild;)e.appendChild(t.firstChild)}},"undefined"!=typeof MSApp&&MSApp.execUnsafeLocalFunction?function(e,t,n,r){MSApp.execUnsafeLocalFunction((function(){return he(e,t)}))}:he);function me(e,t){if(t){var n=e.firstChild;if(n&&n===e.lastChild&&3===n.nodeType)return void(n.nodeValue=t)}e.textContent=t}var ve={animationIterationCount:!0,borderImageOutset:!0,borderImageSlice:!0,borderImageWidth:!0,boxFlex:!0,boxFlexGroup:!0,boxOrdinalGroup:!0,columnCount:!0,columns:!0,flex:!0,flexGrow:!0,flexPositive:!0,flexShrink:!0,flexNegative:!0,flexOrder:!0,gridArea:!0,gridRow:!0,gridRowEnd:!0,gridRowSpan:!0,gridRowStart:!0,gridColumn:!0,gridColumnEnd:!0,gridColumnSpan:!0,gridColumnStart:!0,fontWeight:!0,lineClamp:!0,lineHeight:!0,opacity:!0,order:!0,orphans:!0,tabSize:!0,widows:!0,zIndex:!0,zoom:!0,fillOpacity:!0,floodOpacity:!0,stopOpacity:!0,strokeDasharray:!0,strokeDashoffset:!0,strokeMiterlimit:!0,strokeOpacity:!0,strokeWidth:!0},be=["Webkit","ms","Moz","O"];function Me(e,t,n){return null==t||"boolean"==typeof t||""===t?"":n||"number"!=typeof t||0===t||ve.hasOwnProperty(e)&&ve[e]?(""+t).trim():t+"px"}function Ee(e,t){for(var n in e=e.style,t)if(t.hasOwnProperty(n)){var r=0===n.indexOf("--"),a=Me(n,t[n],r);"float"===n&&(n="cssFloat"),r?e.setProperty(n,a):e[n]=a}}Object.keys(ve).forEach((function(e){be.forEach((function(t){t=t+e.charAt(0).toUpperCase()+e.substring(1),ve[t]=ve[e]}))}));var Le=a({menuitem:!0},{area:!0,base:!0,br:!0,col:!0,embed:!0,hr:!0,img:!0,input:!0,keygen:!0,link:!0,meta:!0,param:!0,source:!0,track:!0,wbr:!0});function Ne(e,t){if(t){if(Le[e]&&(null!=t.children||null!=t.dangerouslySetInnerHTML))throw Error(o(137,e));if(null!=t.dangerouslySetInnerHTML){if(null!=t.children)throw Error(o(60));if("object"!=typeof t.dangerouslySetInnerHTML||!("__html"in t.dangerouslySetInnerHTML))throw Error(o(61))}if(null!=t.style&&"object"!=typeof t.style)throw Error(o(62))}}function we(e,t){if(-1===e.indexOf("-"))return"string"==typeof t.is;switch(e){case"annotation-xml":case"color-profile":case"font-face":case"font-face-src":case"font-face-uri":case"font-face-format":case"font-face-name":case"missing-glyph":return!1;default:return!0}}function Se(e){return(e=e.target||e.srcElement||window).correspondingUseElement&&(e=e.correspondingUseElement),3===e.nodeType?e.parentNode:e}var xe=null,ke=null,je=null;function Te(e){if(e=Jr(e)){if("function"!=typeof xe)throw Error(o(280));var t=e.stateNode;t&&(t=ta(t),xe(e.stateNode,e.type,t))}}function Ce(e){ke?je?je.push(e):je=[e]:ke=e}function Ie(){if(ke){var e=ke,t=je;if(je=ke=null,Te(e),t)for(e=0;e<t.length;e++)Te(t[e])}}function De(e,t){return e(t)}function Oe(e,t,n,r,a){return e(t,n,r,a)}function ze(){}var Ae=De,_e=!1,Pe=!1;function Ue(){null===ke&&null===je||(ze(),Ie())}function Ye(e,t){var n=e.stateNode;if(null===n)return null;var r=ta(n);if(null===r)return null;n=r[t];e:switch(t){case"onClick":case"onClickCapture":case"onDoubleClick":case"onDoubleClickCapture":case"onMouseDown":case"onMouseDownCapture":case"onMouseMove":case"onMouseMoveCapture":case"onMouseUp":case"onMouseUpCapture":case"onMouseEnter":(r=!r.disabled)||(r=!("button"===(e=e.type)||"input"===e||"select"===e||"textarea"===e)),e=!r;break e;default:e=!1}if(e)return null;if(n&&"function"!=typeof n)throw Error(o(231,t,typeof n));return n}var Qe=!1;if(f)try{var Re={};Object.defineProperty(Re,"passive",{get:function(){Qe=!0}}),window.addEventListener("test",Re,Re),window.removeEventListener("test",Re,Re)}catch(he){Qe=!1}function Fe(e,t,n,r,a,l,o,i,u){var s=Array.prototype.slice.call(arguments,3);try{t.apply(n,s)}catch(e){this.onError(e)}}var Ve=!1,Be=null,We=!1,He=null,Ke={onError:function(e){Ve=!0,Be=e}};function Ge(e,t,n,r,a,l,o,i,u){Ve=!1,Be=null,Fe.apply(Ke,arguments)}function $e(e){var t=e,n=e;if(e.alternate)for(;t.return;)t=t.return;else{e=t;do{0!=(1026&(t=e).flags)&&(n=t.return),e=t.return}while(e)}return 3===t.tag?n:null}function qe(e){if(13===e.tag){var t=e.memoizedState;if(null===t&&null!==(e=e.alternate)&&(t=e.memoizedState),null!==t)return t.dehydrated}return null}function Ze(e){if($e(e)!==e)throw Error(o(188))}function Xe(e){if(!(e=function(e){var t=e.alternate;if(!t){if(null===(t=$e(e)))throw Error(o(188));return t!==e?null:e}for(var n=e,r=t;;){var a=n.return;if(null===a)break;var l=a.alternate;if(null===l){if(null!==(r=a.return)){n=r;continue}break}if(a.child===l.child){for(l=a.child;l;){if(l===n)return Ze(a),e;if(l===r)return Ze(a),t;l=l.sibling}throw Error(o(188))}if(n.return!==r.return)n=a,r=l;else{for(var i=!1,u=a.child;u;){if(u===n){i=!0,n=a,r=l;break}if(u===r){i=!0,r=a,n=l;break}u=u.sibling}if(!i){for(u=l.child;u;){if(u===n){i=!0,n=l,r=a;break}if(u===r){i=!0,r=l,n=a;break}u=u.sibling}if(!i)throw Error(o(189))}}if(n.alternate!==r)throw Error(o(190))}if(3!==n.tag)throw Error(o(188));return n.stateNode.current===n?e:t}(e)))return null;for(var t=e;;){if(5===t.tag||6===t.tag)return t;if(t.child)t.child.return=t,t=t.child;else{if(t===e)break;for(;!t.sibling;){if(!t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}}return null}function Je(e,t){for(var n=e.alternate;null!==t;){if(t===e||t===n)return!0;t=t.return}return!1}var et,tt,nt,rt,at=!1,lt=[],ot=null,it=null,ut=null,st=new Map,ct=new Map,ft=[],dt="mousedown mouseup touchcancel touchend touchstart auxclick dblclick pointercancel pointerdown pointerup dragend dragstart drop compositionend compositionstart keydown keypress keyup input textInput copy cut paste click change contextmenu reset submit".split(" ");function pt(e,t,n,r,a){return{blockedOn:e,domEventName:t,eventSystemFlags:16|n,nativeEvent:a,targetContainers:[r]}}function yt(e,t){switch(e){case"focusin":case"focusout":ot=null;break;case"dragenter":case"dragleave":it=null;break;case"mouseover":case"mouseout":ut=null;break;case"pointerover":case"pointerout":st.delete(t.pointerId);break;case"gotpointercapture":case"lostpointercapture":ct.delete(t.pointerId)}}function ht(e,t,n,r,a,l){return null===e||e.nativeEvent!==l?(e=pt(t,n,r,a,l),null!==t&&null!==(t=Jr(t))&&tt(t),e):(e.eventSystemFlags|=r,t=e.targetContainers,null!==a&&-1===t.indexOf(a)&&t.push(a),e)}function gt(e){var t=Xr(e.target);if(null!==t){var n=$e(t);if(null!==n)if(13===(t=n.tag)){if(null!==(t=qe(n)))return e.blockedOn=t,void rt(e.lanePriority,(function(){l.unstable_runWithPriority(e.priority,(function(){nt(n)}))}))}else if(3===t&&n.stateNode.hydrate)return void(e.blockedOn=3===n.tag?n.stateNode.containerInfo:null)}e.blockedOn=null}function mt(e){if(null!==e.blockedOn)return!1;for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n)return null!==(t=Jr(n))&&tt(t),e.blockedOn=n,!1;t.shift()}return!0}function vt(e,t,n){mt(e)&&n.delete(t)}function bt(){for(at=!1;0<lt.length;){var e=lt[0];if(null!==e.blockedOn){null!==(e=Jr(e.blockedOn))&&et(e);break}for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n){e.blockedOn=n;break}t.shift()}null===e.blockedOn&&lt.shift()}null!==ot&&mt(ot)&&(ot=null),null!==it&&mt(it)&&(it=null),null!==ut&&mt(ut)&&(ut=null),st.forEach(vt),ct.forEach(vt)}function Mt(e,t){e.blockedOn===t&&(e.blockedOn=null,at||(at=!0,l.unstable_scheduleCallback(l.unstable_NormalPriority,bt)))}function Et(e){function t(t){return Mt(t,e)}if(0<lt.length){Mt(lt[0],e);for(var n=1;n<lt.length;n++){var r=lt[n];r.blockedOn===e&&(r.blockedOn=null)}}for(null!==ot&&Mt(ot,e),null!==it&&Mt(it,e),null!==ut&&Mt(ut,e),st.forEach(t),ct.forEach(t),n=0;n<ft.length;n++)(r=ft[n]).blockedOn===e&&(r.blockedOn=null);for(;0<ft.length&&null===(n=ft[0]).blockedOn;)gt(n),null===n.blockedOn&&ft.shift()}function Lt(e,t){var n={};return n[e.toLowerCase()]=t.toLowerCase(),n["Webkit"+e]="webkit"+t,n["Moz"+e]="moz"+t,n}var Nt={animationend:Lt("Animation","AnimationEnd"),animationiteration:Lt("Animation","AnimationIteration"),animationstart:Lt("Animation","AnimationStart"),transitionend:Lt("Transition","TransitionEnd")},wt={},St={};function xt(e){if(wt[e])return wt[e];if(!Nt[e])return e;var t,n=Nt[e];for(t in n)if(n.hasOwnProperty(t)&&t in St)return wt[e]=n[t];return e}f&&(St=document.createElement("div").style,"AnimationEvent"in window||(delete Nt.animationend.animation,delete Nt.animationiteration.animation,delete Nt.animationstart.animation),"TransitionEvent"in window||delete Nt.transitionend.transition);var kt=xt("animationend"),jt=xt("animationiteration"),Tt=xt("animationstart"),Ct=xt("transitionend"),It=new Map,Dt=new Map,Ot=["abort","abort",kt,"animationEnd",jt,"animationIteration",Tt,"animationStart","canplay","canPlay","canplaythrough","canPlayThrough","durationchange","durationChange","emptied","emptied","encrypted","encrypted","ended","ended","error","error","gotpointercapture","gotPointerCapture","load","load","loadeddata","loadedData","loadedmetadata","loadedMetadata","loadstart","loadStart","lostpointercapture","lostPointerCapture","playing","playing","progress","progress","seeking","seeking","stalled","stalled","suspend","suspend","timeupdate","timeUpdate",Ct,"transitionEnd","waiting","waiting"];function zt(e,t){for(var n=0;n<e.length;n+=2){var r=e[n],a=e[n+1];a="on"+(a[0].toUpperCase()+a.slice(1)),Dt.set(r,t),It.set(r,a),s(a,[r])}}(0,l.unstable_now)();var At=8;function _t(e){if(0!=(1&e))return At=15,1;if(0!=(2&e))return At=14,2;if(0!=(4&e))return At=13,4;var t=24&e;return 0!==t?(At=12,t):0!=(32&e)?(At=11,32):0!=(t=192&e)?(At=10,t):0!=(256&e)?(At=9,256):0!=(t=3584&e)?(At=8,t):0!=(4096&e)?(At=7,4096):0!=(t=4186112&e)?(At=6,t):0!=(t=62914560&e)?(At=5,t):67108864&e?(At=4,67108864):0!=(134217728&e)?(At=3,134217728):0!=(t=805306368&e)?(At=2,t):0!=(1073741824&e)?(At=1,1073741824):(At=8,e)}function Pt(e,t){var n=e.pendingLanes;if(0===n)return At=0;var r=0,a=0,l=e.expiredLanes,o=e.suspendedLanes,i=e.pingedLanes;if(0!==l)r=l,a=At=15;else if(0!=(l=134217727&n)){var u=l&~o;0!==u?(r=_t(u),a=At):0!=(i&=l)&&(r=_t(i),a=At)}else 0!=(l=n&~o)?(r=_t(l),a=At):0!==i&&(r=_t(i),a=At);if(0===r)return 0;if(r=n&((0>(r=31-Vt(r))?0:1<<r)<<1)-1,0!==t&&t!==r&&0==(t&o)){if(_t(t),a<=At)return t;At=a}if(0!==(t=e.entangledLanes))for(e=e.entanglements,t&=r;0<t;)a=1<<(n=31-Vt(t)),r|=e[n],t&=~a;return r}function Ut(e){return 0!=(e=-1073741825&e.pendingLanes)?e:1073741824&e?1073741824:0}function Yt(e,t){switch(e){case 15:return 1;case 14:return 2;case 12:return 0===(e=Qt(24&~t))?Yt(10,t):e;case 10:return 0===(e=Qt(192&~t))?Yt(8,t):e;case 8:return 0===(e=Qt(3584&~t))&&0===(e=Qt(4186112&~t))&&(e=512),e;case 2:return 0===(t=Qt(805306368&~t))&&(t=268435456),t}throw Error(o(358,e))}function Qt(e){return e&-e}function Rt(e){for(var t=[],n=0;31>n;n++)t.push(e);return t}function Ft(e,t,n){e.pendingLanes|=t;var r=t-1;e.suspendedLanes&=r,e.pingedLanes&=r,(e=e.eventTimes)[t=31-Vt(t)]=n}var Vt=Math.clz32?Math.clz32:function(e){return 0===e?32:31-(Bt(e)/Wt|0)|0},Bt=Math.log,Wt=Math.LN2,Ht=l.unstable_UserBlockingPriority,Kt=l.unstable_runWithPriority,Gt=!0;function $t(e,t,n,r){_e||ze();var a=Zt,l=_e;_e=!0;try{Oe(a,e,t,n,r)}finally{(_e=l)||Ue()}}function qt(e,t,n,r){Kt(Ht,Zt.bind(null,e,t,n,r))}function Zt(e,t,n,r){var a;if(Gt)if((a=0==(4&t))&&0<lt.length&&-1<dt.indexOf(e))e=pt(null,e,t,n,r),lt.push(e);else{var l=Xt(e,t,n,r);if(null===l)a&&yt(e,r);else{if(a){if(-1<dt.indexOf(e))return e=pt(l,e,t,n,r),void lt.push(e);if(function(e,t,n,r,a){switch(t){case"focusin":return ot=ht(ot,e,t,n,r,a),!0;case"dragenter":return it=ht(it,e,t,n,r,a),!0;case"mouseover":return ut=ht(ut,e,t,n,r,a),!0;case"pointerover":var l=a.pointerId;return st.set(l,ht(st.get(l)||null,e,t,n,r,a)),!0;case"gotpointercapture":return l=a.pointerId,ct.set(l,ht(ct.get(l)||null,e,t,n,r,a)),!0}return!1}(l,e,t,n,r))return;yt(e,r)}Ir(e,t,r,null,n)}}}function Xt(e,t,n,r){var a=Se(r);if(null!==(a=Xr(a))){var l=$e(a);if(null===l)a=null;else{var o=l.tag;if(13===o){if(null!==(a=qe(l)))return a;a=null}else if(3===o){if(l.stateNode.hydrate)return 3===l.tag?l.stateNode.containerInfo:null;a=null}else l!==a&&(a=null)}}return Ir(e,t,r,a,n),null}var Jt=null,en=null,tn=null;function nn(){if(tn)return tn;var e,t,n=en,r=n.length,a="value"in Jt?Jt.value:Jt.textContent,l=a.length;for(e=0;e<r&&n[e]===a[e];e++);var o=r-e;for(t=1;t<=o&&n[r-t]===a[l-t];t++);return tn=a.slice(e,1<t?1-t:void 0)}function rn(e){var t=e.keyCode;return"charCode"in e?0===(e=e.charCode)&&13===t&&(e=13):e=t,10===e&&(e=13),32<=e||13===e?e:0}function an(){return!0}function ln(){return!1}function on(e){function t(t,n,r,a,l){for(var o in this._reactName=t,this._targetInst=r,this.type=n,this.nativeEvent=a,this.target=l,this.currentTarget=null,e)e.hasOwnProperty(o)&&(t=e[o],this[o]=t?t(a):a[o]);return this.isDefaultPrevented=(null!=a.defaultPrevented?a.defaultPrevented:!1===a.returnValue)?an:ln,this.isPropagationStopped=ln,this}return a(t.prototype,{preventDefault:function(){this.defaultPrevented=!0;var e=this.nativeEvent;e&&(e.preventDefault?e.preventDefault():"unknown"!=typeof e.returnValue&&(e.returnValue=!1),this.isDefaultPrevented=an)},stopPropagation:function(){var e=this.nativeEvent;e&&(e.stopPropagation?e.stopPropagation():"unknown"!=typeof e.cancelBubble&&(e.cancelBubble=!0),this.isPropagationStopped=an)},persist:function(){},isPersistent:an}),t}var un,sn,cn,fn={eventPhase:0,bubbles:0,cancelable:0,timeStamp:function(e){return e.timeStamp||Date.now()},defaultPrevented:0,isTrusted:0},dn=on(fn),pn=a({},fn,{view:0,detail:0}),yn=on(pn),hn=a({},pn,{screenX:0,screenY:0,clientX:0,clientY:0,pageX:0,pageY:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,getModifierState:xn,button:0,buttons:0,relatedTarget:function(e){return void 0===e.relatedTarget?e.fromElement===e.srcElement?e.toElement:e.fromElement:e.relatedTarget},movementX:function(e){return"movementX"in e?e.movementX:(e!==cn&&(cn&&"mousemove"===e.type?(un=e.screenX-cn.screenX,sn=e.screenY-cn.screenY):sn=un=0,cn=e),un)},movementY:function(e){return"movementY"in e?e.movementY:sn}}),gn=on(hn),mn=on(a({},hn,{dataTransfer:0})),vn=on(a({},pn,{relatedTarget:0})),bn=on(a({},fn,{animationName:0,elapsedTime:0,pseudoElement:0})),Mn=on(a({},fn,{clipboardData:function(e){return"clipboardData"in e?e.clipboardData:window.clipboardData}})),En=on(a({},fn,{data:0})),Ln={Esc:"Escape",Spacebar:" ",Left:"ArrowLeft",Up:"ArrowUp",Right:"ArrowRight",Down:"ArrowDown",Del:"Delete",Win:"OS",Menu:"ContextMenu",Apps:"ContextMenu",Scroll:"ScrollLock",MozPrintableKey:"Unidentified"},Nn={8:"Backspace",9:"Tab",12:"Clear",13:"Enter",16:"Shift",17:"Control",18:"Alt",19:"Pause",20:"CapsLock",27:"Escape",32:" ",33:"PageUp",34:"PageDown",35:"End",36:"Home",37:"ArrowLeft",38:"ArrowUp",39:"ArrowRight",40:"ArrowDown",45:"Insert",46:"Delete",112:"F1",113:"F2",114:"F3",115:"F4",116:"F5",117:"F6",118:"F7",119:"F8",120:"F9",121:"F10",122:"F11",123:"F12",144:"NumLock",145:"ScrollLock",224:"Meta"},wn={Alt:"altKey",Control:"ctrlKey",Meta:"metaKey",Shift:"shiftKey"};function Sn(e){var t=this.nativeEvent;return t.getModifierState?t.getModifierState(e):!!(e=wn[e])&&!!t[e]}function xn(){return Sn}var kn=on(a({},pn,{key:function(e){if(e.key){var t=Ln[e.key]||e.key;if("Unidentified"!==t)return t}return"keypress"===e.type?13===(e=rn(e))?"Enter":String.fromCharCode(e):"keydown"===e.type||"keyup"===e.type?Nn[e.keyCode]||"Unidentified":""},code:0,location:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,repeat:0,locale:0,getModifierState:xn,charCode:function(e){return"keypress"===e.type?rn(e):0},keyCode:function(e){return"keydown"===e.type||"keyup"===e.type?e.keyCode:0},which:function(e){return"keypress"===e.type?rn(e):"keydown"===e.type||"keyup"===e.type?e.keyCode:0}})),jn=on(a({},hn,{pointerId:0,width:0,height:0,pressure:0,tangentialPressure:0,tiltX:0,tiltY:0,twist:0,pointerType:0,isPrimary:0})),Tn=on(a({},pn,{touches:0,targetTouches:0,changedTouches:0,altKey:0,metaKey:0,ctrlKey:0,shiftKey:0,getModifierState:xn})),Cn=on(a({},fn,{propertyName:0,elapsedTime:0,pseudoElement:0})),In=on(a({},hn,{deltaX:function(e){return"deltaX"in e?e.deltaX:"wheelDeltaX"in e?-e.wheelDeltaX:0},deltaY:function(e){return"deltaY"in e?e.deltaY:"wheelDeltaY"in e?-e.wheelDeltaY:"wheelDelta"in e?-e.wheelDelta:0},deltaZ:0,deltaMode:0})),Dn=[9,13,27,32],On=f&&"CompositionEvent"in window,zn=null;f&&"documentMode"in document&&(zn=document.documentMode);var An=f&&"TextEvent"in window&&!zn,_n=f&&(!On||zn&&8<zn&&11>=zn),Pn=String.fromCharCode(32),Un=!1;function Yn(e,t){switch(e){case"keyup":return-1!==Dn.indexOf(t.keyCode);case"keydown":return 229!==t.keyCode;case"keypress":case"mousedown":case"focusout":return!0;default:return!1}}function Qn(e){return"object"==typeof(e=e.detail)&&"data"in e?e.data:null}var Rn=!1,Fn={color:!0,date:!0,datetime:!0,"datetime-local":!0,email:!0,month:!0,number:!0,password:!0,range:!0,search:!0,tel:!0,text:!0,time:!0,url:!0,week:!0};function Vn(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return"input"===t?!!Fn[e.type]:"textarea"===t}function Bn(e,t,n,r){Ce(r),0<(t=Or(t,"onChange")).length&&(n=new dn("onChange","change",null,n,r),e.push({event:n,listeners:t}))}var Wn=null,Hn=null;function Kn(e){Sr(e,0)}function Gn(e){if(Z(ea(e)))return e}function $n(e,t){if("change"===e)return t}var qn=!1;if(f){var Zn;if(f){var Xn="oninput"in document;if(!Xn){var Jn=document.createElement("div");Jn.setAttribute("oninput","return;"),Xn="function"==typeof Jn.oninput}Zn=Xn}else Zn=!1;qn=Zn&&(!document.documentMode||9<document.documentMode)}function er(){Wn&&(Wn.detachEvent("onpropertychange",tr),Hn=Wn=null)}function tr(e){if("value"===e.propertyName&&Gn(Hn)){var t=[];if(Bn(t,Hn,e,Se(e)),e=Kn,_e)e(t);else{_e=!0;try{De(e,t)}finally{_e=!1,Ue()}}}}function nr(e,t,n){"focusin"===e?(er(),Hn=n,(Wn=t).attachEvent("onpropertychange",tr)):"focusout"===e&&er()}function rr(e){if("selectionchange"===e||"keyup"===e||"keydown"===e)return Gn(Hn)}function ar(e,t){if("click"===e)return Gn(t)}function lr(e,t){if("input"===e||"change"===e)return Gn(t)}var or="function"==typeof Object.is?Object.is:function(e,t){return e===t&&(0!==e||1/e==1/t)||e!=e&&t!=t},ir=Object.prototype.hasOwnProperty;function ur(e,t){if(or(e,t))return!0;if("object"!=typeof e||null===e||"object"!=typeof t||null===t)return!1;var n=Object.keys(e),r=Object.keys(t);if(n.length!==r.length)return!1;for(r=0;r<n.length;r++)if(!ir.call(t,n[r])||!or(e[n[r]],t[n[r]]))return!1;return!0}function sr(e){for(;e&&e.firstChild;)e=e.firstChild;return e}function cr(e,t){var n,r=sr(e);for(e=0;r;){if(3===r.nodeType){if(n=e+r.textContent.length,e<=t&&n>=t)return{node:r,offset:t-e};e=n}e:{for(;r;){if(r.nextSibling){r=r.nextSibling;break e}r=r.parentNode}r=void 0}r=sr(r)}}function fr(e,t){return!(!e||!t)&&(e===t||(!e||3!==e.nodeType)&&(t&&3===t.nodeType?fr(e,t.parentNode):"contains"in e?e.contains(t):!!e.compareDocumentPosition&&!!(16&e.compareDocumentPosition(t))))}function dr(){for(var e=window,t=X();t instanceof e.HTMLIFrameElement;){try{var n="string"==typeof t.contentWindow.location.href}catch(e){n=!1}if(!n)break;t=X((e=t.contentWindow).document)}return t}function pr(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return t&&("input"===t&&("text"===e.type||"search"===e.type||"tel"===e.type||"url"===e.type||"password"===e.type)||"textarea"===t||"true"===e.contentEditable)}var yr=f&&"documentMode"in document&&11>=document.documentMode,hr=null,gr=null,mr=null,vr=!1;function br(e,t,n){var r=n.window===n?n.document:9===n.nodeType?n:n.ownerDocument;vr||null==hr||hr!==X(r)||(r="selectionStart"in(r=hr)&&pr(r)?{start:r.selectionStart,end:r.selectionEnd}:{anchorNode:(r=(r.ownerDocument&&r.ownerDocument.defaultView||window).getSelection()).anchorNode,anchorOffset:r.anchorOffset,focusNode:r.focusNode,focusOffset:r.focusOffset},mr&&ur(mr,r)||(mr=r,0<(r=Or(gr,"onSelect")).length&&(t=new dn("onSelect","select",null,t,n),e.push({event:t,listeners:r}),t.target=hr)))}zt("cancel cancel click click close close contextmenu contextMenu copy copy cut cut auxclick auxClick dblclick doubleClick dragend dragEnd dragstart dragStart drop drop focusin focus focusout blur input input invalid invalid keydown keyDown keypress keyPress keyup keyUp mousedown mouseDown mouseup mouseUp paste paste pause pause play play pointercancel pointerCancel pointerdown pointerDown pointerup pointerUp ratechange rateChange reset reset seeked seeked submit submit touchcancel touchCancel touchend touchEnd touchstart touchStart volumechange volumeChange".split(" "),0),zt("drag drag dragenter dragEnter dragexit dragExit dragleave dragLeave dragover dragOver mousemove mouseMove mouseout mouseOut mouseover mouseOver pointermove pointerMove pointerout pointerOut pointerover pointerOver scroll scroll toggle toggle touchmove touchMove wheel wheel".split(" "),1),zt(Ot,2);for(var Mr="change selectionchange textInput compositionstart compositionend compositionupdate".split(" "),Er=0;Er<Mr.length;Er++)Dt.set(Mr[Er],0);c("onMouseEnter",["mouseout","mouseover"]),c("onMouseLeave",["mouseout","mouseover"]),c("onPointerEnter",["pointerout","pointerover"]),c("onPointerLeave",["pointerout","pointerover"]),s("onChange","change click focusin focusout input keydown keyup selectionchange".split(" ")),s("onSelect","focusout contextmenu dragend focusin keydown keyup mousedown mouseup selectionchange".split(" ")),s("onBeforeInput",["compositionend","keypress","textInput","paste"]),s("onCompositionEnd","compositionend focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionStart","compositionstart focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionUpdate","compositionupdate focusout keydown keypress keyup mousedown".split(" "));var Lr="abort canplay canplaythrough durationchange emptied encrypted ended error loadeddata loadedmetadata loadstart pause play playing progress ratechange seeked seeking stalled suspend timeupdate volumechange waiting".split(" "),Nr=new Set("cancel close invalid load scroll toggle".split(" ").concat(Lr));function wr(e,t,n){var r=e.type||"unknown-event";e.currentTarget=n,function(e,t,n,r,a,l,i,u,s){if(Ge.apply(this,arguments),Ve){if(!Ve)throw Error(o(198));var c=Be;Ve=!1,Be=null,We||(We=!0,He=c)}}(r,t,void 0,e),e.currentTarget=null}function Sr(e,t){t=0!=(4&t);for(var n=0;n<e.length;n++){var r=e[n],a=r.event;r=r.listeners;e:{var l=void 0;if(t)for(var o=r.length-1;0<=o;o--){var i=r[o],u=i.instance,s=i.currentTarget;if(i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}else for(o=0;o<r.length;o++){if(u=(i=r[o]).instance,s=i.currentTarget,i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}}}if(We)throw e=He,We=!1,He=null,e}function xr(e,t){var n=na(t),r=e+"__bubble";n.has(r)||(Cr(t,e,2,!1),n.add(r))}var kr="_reactListening"+Math.random().toString(36).slice(2);function jr(e){e[kr]||(e[kr]=!0,i.forEach((function(t){Nr.has(t)||Tr(t,!1,e,null),Tr(t,!0,e,null)})))}function Tr(e,t,n,r){var a=4<arguments.length&&void 0!==arguments[4]?arguments[4]:0,l=n;if("selectionchange"===e&&9!==n.nodeType&&(l=n.ownerDocument),null!==r&&!t&&Nr.has(e)){if("scroll"!==e)return;a|=2,l=r}var o=na(l),i=e+"__"+(t?"capture":"bubble");o.has(i)||(t&&(a|=4),Cr(l,e,a,t),o.add(i))}function Cr(e,t,n,r){var a=Dt.get(t);switch(void 0===a?2:a){case 0:a=$t;break;case 1:a=qt;break;default:a=Zt}n=a.bind(null,t,n,e),a=void 0,!Qe||"touchstart"!==t&&"touchmove"!==t&&"wheel"!==t||(a=!0),r?void 0!==a?e.addEventListener(t,n,{capture:!0,passive:a}):e.addEventListener(t,n,!0):void 0!==a?e.addEventListener(t,n,{passive:a}):e.addEventListener(t,n,!1)}function Ir(e,t,n,r,a){var l=r;if(0==(1&t)&&0==(2&t)&&null!==r)e:for(;;){if(null===r)return;var o=r.tag;if(3===o||4===o){var i=r.stateNode.containerInfo;if(i===a||8===i.nodeType&&i.parentNode===a)break;if(4===o)for(o=r.return;null!==o;){var u=o.tag;if((3===u||4===u)&&((u=o.stateNode.containerInfo)===a||8===u.nodeType&&u.parentNode===a))return;o=o.return}for(;null!==i;){if(null===(o=Xr(i)))return;if(5===(u=o.tag)||6===u){r=l=o;continue e}i=i.parentNode}}r=r.return}!function(e,t,n){if(Pe)return e();Pe=!0;try{Ae(e,t,n)}finally{Pe=!1,Ue()}}((function(){var r=l,a=Se(n),o=[];e:{var i=It.get(e);if(void 0!==i){var u=dn,s=e;switch(e){case"keypress":if(0===rn(n))break e;case"keydown":case"keyup":u=kn;break;case"focusin":s="focus",u=vn;break;case"focusout":s="blur",u=vn;break;case"beforeblur":case"afterblur":u=vn;break;case"click":if(2===n.button)break e;case"auxclick":case"dblclick":case"mousedown":case"mousemove":case"mouseup":case"mouseout":case"mouseover":case"contextmenu":u=gn;break;case"drag":case"dragend":case"dragenter":case"dragexit":case"dragleave":case"dragover":case"dragstart":case"drop":u=mn;break;case"touchcancel":case"touchend":case"touchmove":case"touchstart":u=Tn;break;case kt:case jt:case Tt:u=bn;break;case Ct:u=Cn;break;case"scroll":u=yn;break;case"wheel":u=In;break;case"copy":case"cut":case"paste":u=Mn;break;case"gotpointercapture":case"lostpointercapture":case"pointercancel":case"pointerdown":case"pointermove":case"pointerout":case"pointerover":case"pointerup":u=jn}var c=0!=(4&t),f=!c&&"scroll"===e,d=c?null!==i?i+"Capture":null:i;c=[];for(var p,y=r;null!==y;){var h=(p=y).stateNode;if(5===p.tag&&null!==h&&(p=h,null!==d&&null!=(h=Ye(y,d))&&c.push(Dr(y,h,p))),f)break;y=y.return}0<c.length&&(i=new u(i,s,null,n,a),o.push({event:i,listeners:c}))}}if(0==(7&t)){if(u="mouseout"===e||"pointerout"===e,(!(i="mouseover"===e||"pointerover"===e)||0!=(16&t)||!(s=n.relatedTarget||n.fromElement)||!Xr(s)&&!s[qr])&&(u||i)&&(i=a.window===a?a:(i=a.ownerDocument)?i.defaultView||i.parentWindow:window,u?(u=r,null!==(s=(s=n.relatedTarget||n.toElement)?Xr(s):null)&&(s!==(f=$e(s))||5!==s.tag&&6!==s.tag)&&(s=null)):(u=null,s=r),u!==s)){if(c=gn,h="onMouseLeave",d="onMouseEnter",y="mouse","pointerout"!==e&&"pointerover"!==e||(c=jn,h="onPointerLeave",d="onPointerEnter",y="pointer"),f=null==u?i:ea(u),p=null==s?i:ea(s),(i=new c(h,y+"leave",u,n,a)).target=f,i.relatedTarget=p,h=null,Xr(a)===r&&((c=new c(d,y+"enter",s,n,a)).target=p,c.relatedTarget=f,h=c),f=h,u&&s)e:{for(d=s,y=0,p=c=u;p;p=zr(p))y++;for(p=0,h=d;h;h=zr(h))p++;for(;0<y-p;)c=zr(c),y--;for(;0<p-y;)d=zr(d),p--;for(;y--;){if(c===d||null!==d&&c===d.alternate)break e;c=zr(c),d=zr(d)}c=null}else c=null;null!==u&&Ar(o,i,u,c,!1),null!==s&&null!==f&&Ar(o,f,s,c,!0)}if("select"===(u=(i=r?ea(r):window).nodeName&&i.nodeName.toLowerCase())||"input"===u&&"file"===i.type)var g=$n;else if(Vn(i))if(qn)g=lr;else{g=rr;var m=nr}else(u=i.nodeName)&&"input"===u.toLowerCase()&&("checkbox"===i.type||"radio"===i.type)&&(g=ar);switch(g&&(g=g(e,r))?Bn(o,g,n,a):(m&&m(e,i,r),"focusout"===e&&(m=i._wrapperState)&&m.controlled&&"number"===i.type&&ae(i,"number",i.value)),m=r?ea(r):window,e){case"focusin":(Vn(m)||"true"===m.contentEditable)&&(hr=m,gr=r,mr=null);break;case"focusout":mr=gr=hr=null;break;case"mousedown":vr=!0;break;case"contextmenu":case"mouseup":case"dragend":vr=!1,br(o,n,a);break;case"selectionchange":if(yr)break;case"keydown":case"keyup":br(o,n,a)}var v;if(On)e:{switch(e){case"compositionstart":var b="onCompositionStart";break e;case"compositionend":b="onCompositionEnd";break e;case"compositionupdate":b="onCompositionUpdate";break e}b=void 0}else Rn?Yn(e,n)&&(b="onCompositionEnd"):"keydown"===e&&229===n.keyCode&&(b="onCompositionStart");b&&(_n&&"ko"!==n.locale&&(Rn||"onCompositionStart"!==b?"onCompositionEnd"===b&&Rn&&(v=nn()):(en="value"in(Jt=a)?Jt.value:Jt.textContent,Rn=!0)),0<(m=Or(r,b)).length&&(b=new En(b,e,null,n,a),o.push({event:b,listeners:m}),(v||null!==(v=Qn(n)))&&(b.data=v))),(v=An?function(e,t){switch(e){case"compositionend":return Qn(t);case"keypress":return 32!==t.which?null:(Un=!0,Pn);case"textInput":return(e=t.data)===Pn&&Un?null:e;default:return null}}(e,n):function(e,t){if(Rn)return"compositionend"===e||!On&&Yn(e,t)?(e=nn(),tn=en=Jt=null,Rn=!1,e):null;switch(e){case"paste":return null;case"keypress":if(!(t.ctrlKey||t.altKey||t.metaKey)||t.ctrlKey&&t.altKey){if(t.char&&1<t.char.length)return t.char;if(t.which)return String.fromCharCode(t.which)}return null;case"compositionend":return _n&&"ko"!==t.locale?null:t.data;default:return null}}(e,n))&&0<(r=Or(r,"onBeforeInput")).length&&(a=new En("onBeforeInput","beforeinput",null,n,a),o.push({event:a,listeners:r}),a.data=v)}Sr(o,t)}))}function Dr(e,t,n){return{instance:e,listener:t,currentTarget:n}}function Or(e,t){for(var n=t+"Capture",r=[];null!==e;){var a=e,l=a.stateNode;5===a.tag&&null!==l&&(a=l,null!=(l=Ye(e,n))&&r.unshift(Dr(e,l,a)),null!=(l=Ye(e,t))&&r.push(Dr(e,l,a))),e=e.return}return r}function zr(e){if(null===e)return null;do{e=e.return}while(e&&5!==e.tag);return e||null}function Ar(e,t,n,r,a){for(var l=t._reactName,o=[];null!==n&&n!==r;){var i=n,u=i.alternate,s=i.stateNode;if(null!==u&&u===r)break;5===i.tag&&null!==s&&(i=s,a?null!=(u=Ye(n,l))&&o.unshift(Dr(n,u,i)):a||null!=(u=Ye(n,l))&&o.push(Dr(n,u,i))),n=n.return}0!==o.length&&e.push({event:t,listeners:o})}function _r(){}var Pr=null,Ur=null;function Yr(e,t){switch(e){case"button":case"input":case"select":case"textarea":return!!t.autoFocus}return!1}function Qr(e,t){return"textarea"===e||"option"===e||"noscript"===e||"string"==typeof t.children||"number"==typeof t.children||"object"==typeof t.dangerouslySetInnerHTML&&null!==t.dangerouslySetInnerHTML&&null!=t.dangerouslySetInnerHTML.__html}var Rr="function"==typeof setTimeout?setTimeout:void 0,Fr="function"==typeof clearTimeout?clearTimeout:void 0;function Vr(e){(1===e.nodeType||9===e.nodeType&&null!=(e=e.body))&&(e.textContent="")}function Br(e){for(;null!=e;e=e.nextSibling){var t=e.nodeType;if(1===t||3===t)break}return e}function Wr(e){e=e.previousSibling;for(var t=0;e;){if(8===e.nodeType){var n=e.data;if("$"===n||"$!"===n||"$?"===n){if(0===t)return e;t--}else"/$"===n&&t++}e=e.previousSibling}return null}var Hr=0,Kr=Math.random().toString(36).slice(2),Gr="__reactFiber$"+Kr,$r="__reactProps$"+Kr,qr="__reactContainer$"+Kr,Zr="__reactEvents$"+Kr;function Xr(e){var t=e[Gr];if(t)return t;for(var n=e.parentNode;n;){if(t=n[qr]||n[Gr]){if(n=t.alternate,null!==t.child||null!==n&&null!==n.child)for(e=Wr(e);null!==e;){if(n=e[Gr])return n;e=Wr(e)}return t}n=(e=n).parentNode}return null}function Jr(e){return!(e=e[Gr]||e[qr])||5!==e.tag&&6!==e.tag&&13!==e.tag&&3!==e.tag?null:e}function ea(e){if(5===e.tag||6===e.tag)return e.stateNode;throw Error(o(33))}function ta(e){return e[$r]||null}function na(e){var t=e[Zr];return void 0===t&&(t=e[Zr]=new Set),t}var ra=[],aa=-1;function la(e){return{current:e}}function oa(e){0>aa||(e.current=ra[aa],ra[aa]=null,aa--)}function ia(e,t){aa++,ra[aa]=e.current,e.current=t}var ua={},sa=la(ua),ca=la(!1),fa=ua;function da(e,t){var n=e.type.contextTypes;if(!n)return ua;var r=e.stateNode;if(r&&r.__reactInternalMemoizedUnmaskedChildContext===t)return r.__reactInternalMemoizedMaskedChildContext;var a,l={};for(a in n)l[a]=t[a];return r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=t,e.__reactInternalMemoizedMaskedChildContext=l),l}function pa(e){return null!=e.childContextTypes}function ya(){oa(ca),oa(sa)}function ha(e,t,n){if(sa.current!==ua)throw Error(o(168));ia(sa,t),ia(ca,n)}function ga(e,t,n){var r=e.stateNode;if(e=t.childContextTypes,"function"!=typeof r.getChildContext)return n;for(var l in r=r.getChildContext())if(!(l in e))throw Error(o(108,K(t)||"Unknown",l));return a({},n,r)}function ma(e){return e=(e=e.stateNode)&&e.__reactInternalMemoizedMergedChildContext||ua,fa=sa.current,ia(sa,e),ia(ca,ca.current),!0}function va(e,t,n){var r=e.stateNode;if(!r)throw Error(o(169));n?(e=ga(e,t,fa),r.__reactInternalMemoizedMergedChildContext=e,oa(ca),oa(sa),ia(sa,e)):oa(ca),ia(ca,n)}var ba=null,Ma=null,Ea=l.unstable_runWithPriority,La=l.unstable_scheduleCallback,Na=l.unstable_cancelCallback,wa=l.unstable_shouldYield,Sa=l.unstable_requestPaint,xa=l.unstable_now,ka=l.unstable_getCurrentPriorityLevel,ja=l.unstable_ImmediatePriority,Ta=l.unstable_UserBlockingPriority,Ca=l.unstable_NormalPriority,Ia=l.unstable_LowPriority,Da=l.unstable_IdlePriority,Oa={},za=void 0!==Sa?Sa:function(){},Aa=null,_a=null,Pa=!1,Ua=xa(),Ya=1e4>Ua?xa:function(){return xa()-Ua};function Qa(){switch(ka()){case ja:return 99;case Ta:return 98;case Ca:return 97;case Ia:return 96;case Da:return 95;default:throw Error(o(332))}}function Ra(e){switch(e){case 99:return ja;case 98:return Ta;case 97:return Ca;case 96:return Ia;case 95:return Da;default:throw Error(o(332))}}function Fa(e,t){return e=Ra(e),Ea(e,t)}function Va(e,t,n){return e=Ra(e),La(e,t,n)}function Ba(){if(null!==_a){var e=_a;_a=null,Na(e)}Wa()}function Wa(){if(!Pa&&null!==Aa){Pa=!0;var e=0;try{var t=Aa;Fa(99,(function(){for(;e<t.length;e++){var n=t[e];do{n=n(!0)}while(null!==n)}})),Aa=null}catch(t){throw null!==Aa&&(Aa=Aa.slice(e+1)),La(ja,Ba),t}finally{Pa=!1}}}var Ha=E.ReactCurrentBatchConfig;function Ka(e,t){if(e&&e.defaultProps){for(var n in t=a({},t),e=e.defaultProps)void 0===t[n]&&(t[n]=e[n]);return t}return t}var Ga=la(null),$a=null,qa=null,Za=null;function Xa(){Za=qa=$a=null}function Ja(e){var t=Ga.current;oa(Ga),e.type._context._currentValue=t}function el(e,t){for(;null!==e;){var n=e.alternate;if((e.childLanes&t)===t){if(null===n||(n.childLanes&t)===t)break;n.childLanes|=t}else e.childLanes|=t,null!==n&&(n.childLanes|=t);e=e.return}}function tl(e,t){$a=e,Za=qa=null,null!==(e=e.dependencies)&&null!==e.firstContext&&(0!=(e.lanes&t)&&(Oo=!0),e.firstContext=null)}function nl(e,t){if(Za!==e&&!1!==t&&0!==t)if("number"==typeof t&&1073741823!==t||(Za=e,t=1073741823),t={context:e,observedBits:t,next:null},null===qa){if(null===$a)throw Error(o(308));qa=t,$a.dependencies={lanes:0,firstContext:t,responders:null}}else qa=qa.next=t;return e._currentValue}var rl=!1;function al(e){e.updateQueue={baseState:e.memoizedState,firstBaseUpdate:null,lastBaseUpdate:null,shared:{pending:null},effects:null}}function ll(e,t){e=e.updateQueue,t.updateQueue===e&&(t.updateQueue={baseState:e.baseState,firstBaseUpdate:e.firstBaseUpdate,lastBaseUpdate:e.lastBaseUpdate,shared:e.shared,effects:e.effects})}function ol(e,t){return{eventTime:e,lane:t,tag:0,payload:null,callback:null,next:null}}function il(e,t){if(null!==(e=e.updateQueue)){var n=(e=e.shared).pending;null===n?t.next=t:(t.next=n.next,n.next=t),e.pending=t}}function ul(e,t){var n=e.updateQueue,r=e.alternate;if(null!==r&&n===(r=r.updateQueue)){var a=null,l=null;if(null!==(n=n.firstBaseUpdate)){do{var o={eventTime:n.eventTime,lane:n.lane,tag:n.tag,payload:n.payload,callback:n.callback,next:null};null===l?a=l=o:l=l.next=o,n=n.next}while(null!==n);null===l?a=l=t:l=l.next=t}else a=l=t;return n={baseState:r.baseState,firstBaseUpdate:a,lastBaseUpdate:l,shared:r.shared,effects:r.effects},void(e.updateQueue=n)}null===(e=n.lastBaseUpdate)?n.firstBaseUpdate=t:e.next=t,n.lastBaseUpdate=t}function sl(e,t,n,r){var l=e.updateQueue;rl=!1;var o=l.firstBaseUpdate,i=l.lastBaseUpdate,u=l.shared.pending;if(null!==u){l.shared.pending=null;var s=u,c=s.next;s.next=null,null===i?o=c:i.next=c,i=s;var f=e.alternate;if(null!==f){var d=(f=f.updateQueue).lastBaseUpdate;d!==i&&(null===d?f.firstBaseUpdate=c:d.next=c,f.lastBaseUpdate=s)}}if(null!==o){for(d=l.baseState,i=0,f=c=s=null;;){u=o.lane;var p=o.eventTime;if((r&u)===u){null!==f&&(f=f.next={eventTime:p,lane:0,tag:o.tag,payload:o.payload,callback:o.callback,next:null});e:{var y=e,h=o;switch(u=t,p=n,h.tag){case 1:if("function"==typeof(y=h.payload)){d=y.call(p,d,u);break e}d=y;break e;case 3:y.flags=-4097&y.flags|64;case 0:if(null==(u="function"==typeof(y=h.payload)?y.call(p,d,u):y))break e;d=a({},d,u);break e;case 2:rl=!0}}null!==o.callback&&(e.flags|=32,null===(u=l.effects)?l.effects=[o]:u.push(o))}else p={eventTime:p,lane:u,tag:o.tag,payload:o.payload,callback:o.callback,next:null},null===f?(c=f=p,s=d):f=f.next=p,i|=u;if(null===(o=o.next)){if(null===(u=l.shared.pending))break;o=u.next,u.next=null,l.lastBaseUpdate=u,l.shared.pending=null}}null===f&&(s=d),l.baseState=s,l.firstBaseUpdate=c,l.lastBaseUpdate=f,Ai|=i,e.lanes=i,e.memoizedState=d}}function cl(e,t,n){if(e=t.effects,t.effects=null,null!==e)for(t=0;t<e.length;t++){var r=e[t],a=r.callback;if(null!==a){if(r.callback=null,r=n,"function"!=typeof a)throw Error(o(191,a));a.call(r)}}}var fl=(new r.Component).refs;function dl(e,t,n,r){n=null==(n=n(r,t=e.memoizedState))?t:a({},t,n),e.memoizedState=n,0===e.lanes&&(e.updateQueue.baseState=n)}var pl={isMounted:function(e){return!!(e=e._reactInternals)&&$e(e)===e},enqueueSetState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueReplaceState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.tag=1,l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueForceUpdate:function(e,t){e=e._reactInternals;var n=ou(),r=iu(e),a=ol(n,r);a.tag=2,null!=t&&(a.callback=t),il(e,a),uu(e,r,n)}};function yl(e,t,n,r,a,l,o){return"function"==typeof(e=e.stateNode).shouldComponentUpdate?e.shouldComponentUpdate(r,l,o):!(t.prototype&&t.prototype.isPureReactComponent&&ur(n,r)&&ur(a,l))}function hl(e,t,n){var r=!1,a=ua,l=t.contextType;return"object"==typeof l&&null!==l?l=nl(l):(a=pa(t)?fa:sa.current,l=(r=null!=(r=t.contextTypes))?da(e,a):ua),t=new t(n,l),e.memoizedState=null!==t.state&&void 0!==t.state?t.state:null,t.updater=pl,e.stateNode=t,t._reactInternals=e,r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=a,e.__reactInternalMemoizedMaskedChildContext=l),t}function gl(e,t,n,r){e=t.state,"function"==typeof t.componentWillReceiveProps&&t.componentWillReceiveProps(n,r),"function"==typeof t.UNSAFE_componentWillReceiveProps&&t.UNSAFE_componentWillReceiveProps(n,r),t.state!==e&&pl.enqueueReplaceState(t,t.state,null)}function ml(e,t,n,r){var a=e.stateNode;a.props=n,a.state=e.memoizedState,a.refs=fl,al(e);var l=t.contextType;"object"==typeof l&&null!==l?a.context=nl(l):(l=pa(t)?fa:sa.current,a.context=da(e,l)),sl(e,n,a,r),a.state=e.memoizedState,"function"==typeof(l=t.getDerivedStateFromProps)&&(dl(e,t,l,n),a.state=e.memoizedState),"function"==typeof t.getDerivedStateFromProps||"function"==typeof a.getSnapshotBeforeUpdate||"function"!=typeof a.UNSAFE_componentWillMount&&"function"!=typeof a.componentWillMount||(t=a.state,"function"==typeof a.componentWillMount&&a.componentWillMount(),"function"==typeof a.UNSAFE_componentWillMount&&a.UNSAFE_componentWillMount(),t!==a.state&&pl.enqueueReplaceState(a,a.state,null),sl(e,n,a,r),a.state=e.memoizedState),"function"==typeof a.componentDidMount&&(e.flags|=4)}var vl=Array.isArray;function bl(e,t,n){if(null!==(e=n.ref)&&"function"!=typeof e&&"object"!=typeof e){if(n._owner){if(n=n._owner){if(1!==n.tag)throw Error(o(309));var r=n.stateNode}if(!r)throw Error(o(147,e));var a=""+e;return null!==t&&null!==t.ref&&"function"==typeof t.ref&&t.ref._stringRef===a?t.ref:((t=function(e){var t=r.refs;t===fl&&(t=r.refs={}),null===e?delete t[a]:t[a]=e})._stringRef=a,t)}if("string"!=typeof e)throw Error(o(284));if(!n._owner)throw Error(o(290,e))}return e}function Ml(e,t){if("textarea"!==e.type)throw Error(o(31,"[object Object]"===Object.prototype.toString.call(t)?"object with keys {"+Object.keys(t).join(", ")+"}":t))}function El(e){function t(t,n){if(e){var r=t.lastEffect;null!==r?(r.nextEffect=n,t.lastEffect=n):t.firstEffect=t.lastEffect=n,n.nextEffect=null,n.flags=8}}function n(n,r){if(!e)return null;for(;null!==r;)t(n,r),r=r.sibling;return null}function r(e,t){for(e=new Map;null!==t;)null!==t.key?e.set(t.key,t):e.set(t.index,t),t=t.sibling;return e}function a(e,t){return(e=Qu(e,t)).index=0,e.sibling=null,e}function l(t,n,r){return t.index=r,e?null!==(r=t.alternate)?(r=r.index)<n?(t.flags=2,n):r:(t.flags=2,n):n}function i(t){return e&&null===t.alternate&&(t.flags=2),t}function u(e,t,n,r){return null===t||6!==t.tag?((t=Bu(n,e.mode,r)).return=e,t):((t=a(t,n)).return=e,t)}function s(e,t,n,r){return null!==t&&t.elementType===n.type?((r=a(t,n.props)).ref=bl(e,t,n),r.return=e,r):((r=Ru(n.type,n.key,n.props,null,e.mode,r)).ref=bl(e,t,n),r.return=e,r)}function c(e,t,n,r){return null===t||4!==t.tag||t.stateNode.containerInfo!==n.containerInfo||t.stateNode.implementation!==n.implementation?((t=Wu(n,e.mode,r)).return=e,t):((t=a(t,n.children||[])).return=e,t)}function f(e,t,n,r,l){return null===t||7!==t.tag?((t=Fu(n,e.mode,r,l)).return=e,t):((t=a(t,n)).return=e,t)}function d(e,t,n){if("string"==typeof t||"number"==typeof t)return(t=Bu(""+t,e.mode,n)).return=e,t;if("object"==typeof t&&null!==t){switch(t.$$typeof){case L:return(n=Ru(t.type,t.key,t.props,null,e.mode,n)).ref=bl(e,null,t),n.return=e,n;case N:return(t=Wu(t,e.mode,n)).return=e,t}if(vl(t)||F(t))return(t=Fu(t,e.mode,n,null)).return=e,t;Ml(e,t)}return null}function p(e,t,n,r){var a=null!==t?t.key:null;if("string"==typeof n||"number"==typeof n)return null!==a?null:u(e,t,""+n,r);if("object"==typeof n&&null!==n){switch(n.$$typeof){case L:return n.key===a?n.type===w?f(e,t,n.props.children,r,a):s(e,t,n,r):null;case N:return n.key===a?c(e,t,n,r):null}if(vl(n)||F(n))return null!==a?null:f(e,t,n,r,null);Ml(e,n)}return null}function y(e,t,n,r,a){if("string"==typeof r||"number"==typeof r)return u(t,e=e.get(n)||null,""+r,a);if("object"==typeof r&&null!==r){switch(r.$$typeof){case L:return e=e.get(null===r.key?n:r.key)||null,r.type===w?f(t,e,r.props.children,a,r.key):s(t,e,r,a);case N:return c(t,e=e.get(null===r.key?n:r.key)||null,r,a)}if(vl(r)||F(r))return f(t,e=e.get(n)||null,r,a,null);Ml(t,r)}return null}function h(a,o,i,u){for(var s=null,c=null,f=o,h=o=0,g=null;null!==f&&h<i.length;h++){f.index>h?(g=f,f=null):g=f.sibling;var m=p(a,f,i[h],u);if(null===m){null===f&&(f=g);break}e&&f&&null===m.alternate&&t(a,f),o=l(m,o,h),null===c?s=m:c.sibling=m,c=m,f=g}if(h===i.length)return n(a,f),s;if(null===f){for(;h<i.length;h++)null!==(f=d(a,i[h],u))&&(o=l(f,o,h),null===c?s=f:c.sibling=f,c=f);return s}for(f=r(a,f);h<i.length;h++)null!==(g=y(f,a,h,i[h],u))&&(e&&null!==g.alternate&&f.delete(null===g.key?h:g.key),o=l(g,o,h),null===c?s=g:c.sibling=g,c=g);return e&&f.forEach((function(e){return t(a,e)})),s}function g(a,i,u,s){var c=F(u);if("function"!=typeof c)throw Error(o(150));if(null==(u=c.call(u)))throw Error(o(151));for(var f=c=null,h=i,g=i=0,m=null,v=u.next();null!==h&&!v.done;g++,v=u.next()){h.index>g?(m=h,h=null):m=h.sibling;var b=p(a,h,v.value,s);if(null===b){null===h&&(h=m);break}e&&h&&null===b.alternate&&t(a,h),i=l(b,i,g),null===f?c=b:f.sibling=b,f=b,h=m}if(v.done)return n(a,h),c;if(null===h){for(;!v.done;g++,v=u.next())null!==(v=d(a,v.value,s))&&(i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return c}for(h=r(a,h);!v.done;g++,v=u.next())null!==(v=y(h,a,g,v.value,s))&&(e&&null!==v.alternate&&h.delete(null===v.key?g:v.key),i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return e&&h.forEach((function(e){return t(a,e)})),c}return function(e,r,l,u){var s="object"==typeof l&&null!==l&&l.type===w&&null===l.key;s&&(l=l.props.children);var c="object"==typeof l&&null!==l;if(c)switch(l.$$typeof){case L:e:{for(c=l.key,s=r;null!==s;){if(s.key===c){switch(s.tag){case 7:if(l.type===w){n(e,s.sibling),(r=a(s,l.props.children)).return=e,e=r;break e}break;default:if(s.elementType===l.type){n(e,s.sibling),(r=a(s,l.props)).ref=bl(e,s,l),r.return=e,e=r;break e}}n(e,s);break}t(e,s),s=s.sibling}l.type===w?((r=Fu(l.props.children,e.mode,u,l.key)).return=e,e=r):((u=Ru(l.type,l.key,l.props,null,e.mode,u)).ref=bl(e,r,l),u.return=e,e=u)}return i(e);case N:e:{for(s=l.key;null!==r;){if(r.key===s){if(4===r.tag&&r.stateNode.containerInfo===l.containerInfo&&r.stateNode.implementation===l.implementation){n(e,r.sibling),(r=a(r,l.children||[])).return=e,e=r;break e}n(e,r);break}t(e,r),r=r.sibling}(r=Wu(l,e.mode,u)).return=e,e=r}return i(e)}if("string"==typeof l||"number"==typeof l)return l=""+l,null!==r&&6===r.tag?(n(e,r.sibling),(r=a(r,l)).return=e,e=r):(n(e,r),(r=Bu(l,e.mode,u)).return=e,e=r),i(e);if(vl(l))return h(e,r,l,u);if(F(l))return g(e,r,l,u);if(c&&Ml(e,l),void 0===l&&!s)switch(e.tag){case 1:case 22:case 0:case 11:case 15:throw Error(o(152,K(e.type)||"Component"))}return n(e,r)}}var Ll=El(!0),Nl=El(!1),wl={},Sl=la(wl),xl=la(wl),kl=la(wl);function jl(e){if(e===wl)throw Error(o(174));return e}function Tl(e,t){switch(ia(kl,t),ia(xl,e),ia(Sl,wl),e=t.nodeType){case 9:case 11:t=(t=t.documentElement)?t.namespaceURI:pe(null,"");break;default:t=pe(t=(e=8===e?t.parentNode:t).namespaceURI||null,e=e.tagName)}oa(Sl),ia(Sl,t)}function Cl(){oa(Sl),oa(xl),oa(kl)}function Il(e){jl(kl.current);var t=jl(Sl.current),n=pe(t,e.type);t!==n&&(ia(xl,e),ia(Sl,n))}function Dl(e){xl.current===e&&(oa(Sl),oa(xl))}var Ol=la(0);function zl(e){for(var t=e;null!==t;){if(13===t.tag){var n=t.memoizedState;if(null!==n&&(null===(n=n.dehydrated)||"$?"===n.data||"$!"===n.data))return t}else if(19===t.tag&&void 0!==t.memoizedProps.revealOrder){if(0!=(64&t.flags))return t}else if(null!==t.child){t.child.return=t,t=t.child;continue}if(t===e)break;for(;null===t.sibling;){if(null===t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}return null}var Al=null,_l=null,Pl=!1;function Ul(e,t){var n=Uu(5,null,null,0);n.elementType="DELETED",n.type="DELETED",n.stateNode=t,n.return=e,n.flags=8,null!==e.lastEffect?(e.lastEffect.nextEffect=n,e.lastEffect=n):e.firstEffect=e.lastEffect=n}function Yl(e,t){switch(e.tag){case 5:var n=e.type;return null!==(t=1!==t.nodeType||n.toLowerCase()!==t.nodeName.toLowerCase()?null:t)&&(e.stateNode=t,!0);case 6:return null!==(t=""===e.pendingProps||3!==t.nodeType?null:t)&&(e.stateNode=t,!0);case 13:default:return!1}}function Ql(e){if(Pl){var t=_l;if(t){var n=t;if(!Yl(e,t)){if(!(t=Br(n.nextSibling))||!Yl(e,t))return e.flags=-1025&e.flags|2,Pl=!1,void(Al=e);Ul(Al,n)}Al=e,_l=Br(t.firstChild)}else e.flags=-1025&e.flags|2,Pl=!1,Al=e}}function Rl(e){for(e=e.return;null!==e&&5!==e.tag&&3!==e.tag&&13!==e.tag;)e=e.return;Al=e}function Fl(e){if(e!==Al)return!1;if(!Pl)return Rl(e),Pl=!0,!1;var t=e.type;if(5!==e.tag||"head"!==t&&"body"!==t&&!Qr(t,e.memoizedProps))for(t=_l;t;)Ul(e,t),t=Br(t.nextSibling);if(Rl(e),13===e.tag){if(!(e=null!==(e=e.memoizedState)?e.dehydrated:null))throw Error(o(317));e:{for(e=e.nextSibling,t=0;e;){if(8===e.nodeType){var n=e.data;if("/$"===n){if(0===t){_l=Br(e.nextSibling);break e}t--}else"$"!==n&&"$!"!==n&&"$?"!==n||t++}e=e.nextSibling}_l=null}}else _l=Al?Br(e.stateNode.nextSibling):null;return!0}function Vl(){_l=Al=null,Pl=!1}var Bl=[];function Wl(){for(var e=0;e<Bl.length;e++)Bl[e]._workInProgressVersionPrimary=null;Bl.length=0}var Hl=E.ReactCurrentDispatcher,Kl=E.ReactCurrentBatchConfig,Gl=0,$l=null,ql=null,Zl=null,Xl=!1,Jl=!1;function eo(){throw Error(o(321))}function to(e,t){if(null===t)return!1;for(var n=0;n<t.length&&n<e.length;n++)if(!or(e[n],t[n]))return!1;return!0}function no(e,t,n,r,a,l){if(Gl=l,$l=t,t.memoizedState=null,t.updateQueue=null,t.lanes=0,Hl.current=null===e||null===e.memoizedState?To:Co,e=n(r,a),Jl){l=0;do{if(Jl=!1,!(25>l))throw Error(o(301));l+=1,Zl=ql=null,t.updateQueue=null,Hl.current=Io,e=n(r,a)}while(Jl)}if(Hl.current=jo,t=null!==ql&&null!==ql.next,Gl=0,Zl=ql=$l=null,Xl=!1,t)throw Error(o(300));return e}function ro(){var e={memoizedState:null,baseState:null,baseQueue:null,queue:null,next:null};return null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e,Zl}function ao(){if(null===ql){var e=$l.alternate;e=null!==e?e.memoizedState:null}else e=ql.next;var t=null===Zl?$l.memoizedState:Zl.next;if(null!==t)Zl=t,ql=e;else{if(null===e)throw Error(o(310));e={memoizedState:(ql=e).memoizedState,baseState:ql.baseState,baseQueue:ql.baseQueue,queue:ql.queue,next:null},null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e}return Zl}function lo(e,t){return"function"==typeof t?t(e):t}function oo(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=ql,a=r.baseQueue,l=n.pending;if(null!==l){if(null!==a){var i=a.next;a.next=l.next,l.next=i}r.baseQueue=a=l,n.pending=null}if(null!==a){a=a.next,r=r.baseState;var u=i=l=null,s=a;do{var c=s.lane;if((Gl&c)===c)null!==u&&(u=u.next={lane:0,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null}),r=s.eagerReducer===e?s.eagerState:e(r,s.action);else{var f={lane:c,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null};null===u?(i=u=f,l=r):u=u.next=f,$l.lanes|=c,Ai|=c}s=s.next}while(null!==s&&s!==a);null===u?l=r:u.next=i,or(r,t.memoizedState)||(Oo=!0),t.memoizedState=r,t.baseState=l,t.baseQueue=u,n.lastRenderedState=r}return[t.memoizedState,n.dispatch]}function io(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=n.dispatch,a=n.pending,l=t.memoizedState;if(null!==a){n.pending=null;var i=a=a.next;do{l=e(l,i.action),i=i.next}while(i!==a);or(l,t.memoizedState)||(Oo=!0),t.memoizedState=l,null===t.baseQueue&&(t.baseState=l),n.lastRenderedState=l}return[l,r]}function uo(e,t,n){var r=t._getVersion;r=r(t._source);var a=t._workInProgressVersionPrimary;if(null!==a?e=a===r:(e=e.mutableReadLanes,(e=(Gl&e)===e)&&(t._workInProgressVersionPrimary=r,Bl.push(t))),e)return n(t._source);throw Bl.push(t),Error(o(350))}function so(e,t,n,r){var a=ki;if(null===a)throw Error(o(349));var l=t._getVersion,i=l(t._source),u=Hl.current,s=u.useState((function(){return uo(a,t,n)})),c=s[1],f=s[0];s=Zl;var d=e.memoizedState,p=d.refs,y=p.getSnapshot,h=d.source;d=d.subscribe;var g=$l;return e.memoizedState={refs:p,source:t,subscribe:r},u.useEffect((function(){p.getSnapshot=n,p.setSnapshot=c;var e=l(t._source);if(!or(i,e)){e=n(t._source),or(f,e)||(c(e),e=iu(g),a.mutableReadLanes|=e&a.pendingLanes),e=a.mutableReadLanes,a.entangledLanes|=e;for(var r=a.entanglements,o=e;0<o;){var u=31-Vt(o),s=1<<u;r[u]|=e,o&=~s}}}),[n,t,r]),u.useEffect((function(){return r(t._source,(function(){var e=p.getSnapshot,n=p.setSnapshot;try{n(e(t._source));var r=iu(g);a.mutableReadLanes|=r&a.pendingLanes}catch(e){n((function(){throw e}))}}))}),[t,r]),or(y,n)&&or(h,t)&&or(d,r)||((e={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:f}).dispatch=c=ko.bind(null,$l,e),s.queue=e,s.baseQueue=null,f=uo(a,t,n),s.memoizedState=s.baseState=f),f}function co(e,t,n){return so(ao(),e,t,n)}function fo(e){var t=ro();return"function"==typeof e&&(e=e()),t.memoizedState=t.baseState=e,e=(e=t.queue={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:e}).dispatch=ko.bind(null,$l,e),[t.memoizedState,e]}function po(e,t,n,r){return e={tag:e,create:t,destroy:n,deps:r,next:null},null===(t=$l.updateQueue)?(t={lastEffect:null},$l.updateQueue=t,t.lastEffect=e.next=e):null===(n=t.lastEffect)?t.lastEffect=e.next=e:(r=n.next,n.next=e,e.next=r,t.lastEffect=e),e}function yo(e){return e={current:e},ro().memoizedState=e}function ho(){return ao().memoizedState}function go(e,t,n,r){var a=ro();$l.flags|=e,a.memoizedState=po(1|t,n,void 0,void 0===r?null:r)}function mo(e,t,n,r){var a=ao();r=void 0===r?null:r;var l=void 0;if(null!==ql){var o=ql.memoizedState;if(l=o.destroy,null!==r&&to(r,o.deps))return void po(t,n,l,r)}$l.flags|=e,a.memoizedState=po(1|t,n,l,r)}function vo(e,t){return go(516,4,e,t)}function bo(e,t){return mo(516,4,e,t)}function Mo(e,t){return mo(4,2,e,t)}function Eo(e,t){return"function"==typeof t?(e=e(),t(e),function(){t(null)}):null!=t?(e=e(),t.current=e,function(){t.current=null}):void 0}function Lo(e,t,n){return n=null!=n?n.concat([e]):null,mo(4,2,Eo.bind(null,t,e),n)}function No(){}function wo(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(n.memoizedState=[e,t],e)}function So(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(e=e(),n.memoizedState=[e,t],e)}function xo(e,t){var n=Qa();Fa(98>n?98:n,(function(){e(!0)})),Fa(97<n?97:n,(function(){var n=Kl.transition;Kl.transition=1;try{e(!1),t()}finally{Kl.transition=n}}))}function ko(e,t,n){var r=ou(),a=iu(e),l={lane:a,action:n,eagerReducer:null,eagerState:null,next:null},o=t.pending;if(null===o?l.next=l:(l.next=o.next,o.next=l),t.pending=l,o=e.alternate,e===$l||null!==o&&o===$l)Jl=Xl=!0;else{if(0===e.lanes&&(null===o||0===o.lanes)&&null!==(o=t.lastRenderedReducer))try{var i=t.lastRenderedState,u=o(i,n);if(l.eagerReducer=o,l.eagerState=u,or(u,i))return}catch(e){}uu(e,a,r)}}var jo={readContext:nl,useCallback:eo,useContext:eo,useEffect:eo,useImperativeHandle:eo,useLayoutEffect:eo,useMemo:eo,useReducer:eo,useRef:eo,useState:eo,useDebugValue:eo,useDeferredValue:eo,useTransition:eo,useMutableSource:eo,useOpaqueIdentifier:eo,unstable_isNewReconciler:!1},To={readContext:nl,useCallback:function(e,t){return ro().memoizedState=[e,void 0===t?null:t],e},useContext:nl,useEffect:vo,useImperativeHandle:function(e,t,n){return n=null!=n?n.concat([e]):null,go(4,2,Eo.bind(null,t,e),n)},useLayoutEffect:function(e,t){return go(4,2,e,t)},useMemo:function(e,t){var n=ro();return t=void 0===t?null:t,e=e(),n.memoizedState=[e,t],e},useReducer:function(e,t,n){var r=ro();return t=void 0!==n?n(t):t,r.memoizedState=r.baseState=t,e=(e=r.queue={pending:null,dispatch:null,lastRenderedReducer:e,lastRenderedState:t}).dispatch=ko.bind(null,$l,e),[r.memoizedState,e]},useRef:yo,useState:fo,useDebugValue:No,useDeferredValue:function(e){var t=fo(e),n=t[0],r=t[1];return vo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=fo(!1),t=e[0];return yo(e=xo.bind(null,e[1])),[e,t]},useMutableSource:function(e,t,n){var r=ro();return r.memoizedState={refs:{getSnapshot:t,setSnapshot:null},source:e,subscribe:n},so(r,e,t,n)},useOpaqueIdentifier:function(){if(Pl){var e=!1,t=function(e){return{$$typeof:A,toString:e,valueOf:e}}((function(){throw e||(e=!0,n("r:"+(Hr++).toString(36))),Error(o(355))})),n=fo(t)[1];return 0==(2&$l.mode)&&($l.flags|=516,po(5,(function(){n("r:"+(Hr++).toString(36))}),void 0,null)),t}return fo(t="r:"+(Hr++).toString(36)),t},unstable_isNewReconciler:!1},Co={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:oo,useRef:ho,useState:function(){return oo(lo)},useDebugValue:No,useDeferredValue:function(e){var t=oo(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=oo(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return oo(lo)[0]},unstable_isNewReconciler:!1},Io={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:io,useRef:ho,useState:function(){return io(lo)},useDebugValue:No,useDeferredValue:function(e){var t=io(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=io(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return io(lo)[0]},unstable_isNewReconciler:!1},Do=E.ReactCurrentOwner,Oo=!1;function zo(e,t,n,r){t.child=null===e?Nl(t,null,n,r):Ll(t,e.child,n,r)}function Ao(e,t,n,r,a){n=n.render;var l=t.ref;return tl(t,a),r=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,r,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function _o(e,t,n,r,a,l){if(null===e){var o=n.type;return"function"!=typeof o||Yu(o)||void 0!==o.defaultProps||null!==n.compare||void 0!==n.defaultProps?((e=Ru(n.type,null,r,t,t.mode,l)).ref=t.ref,e.return=t,t.child=e):(t.tag=15,t.type=o,Po(e,t,o,r,a,l))}return o=e.child,0==(a&l)&&(a=o.memoizedProps,(n=null!==(n=n.compare)?n:ur)(a,r)&&e.ref===t.ref)?Jo(e,t,l):(t.flags|=1,(e=Qu(o,r)).ref=t.ref,e.return=t,t.child=e)}function Po(e,t,n,r,a,l){if(null!==e&&ur(e.memoizedProps,r)&&e.ref===t.ref){if(Oo=!1,0==(l&a))return t.lanes=e.lanes,Jo(e,t,l);0!=(16384&e.flags)&&(Oo=!0)}return Qo(e,t,n,r,l)}function Uo(e,t,n){var r=t.pendingProps,a=r.children,l=null!==e?e.memoizedState:null;if("hidden"===r.mode||"unstable-defer-without-hiding"===r.mode)if(0==(4&t.mode))t.memoizedState={baseLanes:0},gu(0,n);else{if(0==(1073741824&n))return e=null!==l?l.baseLanes|n:n,t.lanes=t.childLanes=1073741824,t.memoizedState={baseLanes:e},gu(0,e),null;t.memoizedState={baseLanes:0},gu(0,null!==l?l.baseLanes:n)}else null!==l?(r=l.baseLanes|n,t.memoizedState=null):r=n,gu(0,r);return zo(e,t,a,n),t.child}function Yo(e,t){var n=t.ref;(null===e&&null!==n||null!==e&&e.ref!==n)&&(t.flags|=128)}function Qo(e,t,n,r,a){var l=pa(n)?fa:sa.current;return l=da(t,l),tl(t,a),n=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,n,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function Ro(e,t,n,r,a){if(pa(n)){var l=!0;ma(t)}else l=!1;if(tl(t,a),null===t.stateNode)null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),hl(t,n,r),ml(t,n,r,a),r=!0;else if(null===e){var o=t.stateNode,i=t.memoizedProps;o.props=i;var u=o.context,s=n.contextType;s="object"==typeof s&&null!==s?nl(s):da(t,s=pa(n)?fa:sa.current);var c=n.getDerivedStateFromProps,f="function"==typeof c||"function"==typeof o.getSnapshotBeforeUpdate;f||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==r||u!==s)&&gl(t,o,r,s),rl=!1;var d=t.memoizedState;o.state=d,sl(t,r,o,a),u=t.memoizedState,i!==r||d!==u||ca.current||rl?("function"==typeof c&&(dl(t,n,c,r),u=t.memoizedState),(i=rl||yl(t,n,i,r,d,u,s))?(f||"function"!=typeof o.UNSAFE_componentWillMount&&"function"!=typeof o.componentWillMount||("function"==typeof o.componentWillMount&&o.componentWillMount(),"function"==typeof o.UNSAFE_componentWillMount&&o.UNSAFE_componentWillMount()),"function"==typeof o.componentDidMount&&(t.flags|=4)):("function"==typeof o.componentDidMount&&(t.flags|=4),t.memoizedProps=r,t.memoizedState=u),o.props=r,o.state=u,o.context=s,r=i):("function"==typeof o.componentDidMount&&(t.flags|=4),r=!1)}else{o=t.stateNode,ll(e,t),i=t.memoizedProps,s=t.type===t.elementType?i:Ka(t.type,i),o.props=s,f=t.pendingProps,d=o.context,u="object"==typeof(u=n.contextType)&&null!==u?nl(u):da(t,u=pa(n)?fa:sa.current);var p=n.getDerivedStateFromProps;(c="function"==typeof p||"function"==typeof o.getSnapshotBeforeUpdate)||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==f||d!==u)&&gl(t,o,r,u),rl=!1,d=t.memoizedState,o.state=d,sl(t,r,o,a);var y=t.memoizedState;i!==f||d!==y||ca.current||rl?("function"==typeof p&&(dl(t,n,p,r),y=t.memoizedState),(s=rl||yl(t,n,s,r,d,y,u))?(c||"function"!=typeof o.UNSAFE_componentWillUpdate&&"function"!=typeof o.componentWillUpdate||("function"==typeof o.componentWillUpdate&&o.componentWillUpdate(r,y,u),"function"==typeof o.UNSAFE_componentWillUpdate&&o.UNSAFE_componentWillUpdate(r,y,u)),"function"==typeof o.componentDidUpdate&&(t.flags|=4),"function"==typeof o.getSnapshotBeforeUpdate&&(t.flags|=256)):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),t.memoizedProps=r,t.memoizedState=y),o.props=r,o.state=y,o.context=u,r=s):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),r=!1)}return Fo(e,t,n,r,l,a)}function Fo(e,t,n,r,a,l){Yo(e,t);var o=0!=(64&t.flags);if(!r&&!o)return a&&va(t,n,!1),Jo(e,t,l);r=t.stateNode,Do.current=t;var i=o&&"function"!=typeof n.getDerivedStateFromError?null:r.render();return t.flags|=1,null!==e&&o?(t.child=Ll(t,e.child,null,l),t.child=Ll(t,null,i,l)):zo(e,t,i,l),t.memoizedState=r.state,a&&va(t,n,!0),t.child}function Vo(e){var t=e.stateNode;t.pendingContext?ha(0,t.pendingContext,t.pendingContext!==t.context):t.context&&ha(0,t.context,!1),Tl(e,t.containerInfo)}var Bo,Wo,Ho,Ko={dehydrated:null,retryLane:0};function Go(e,t,n){var r,a=t.pendingProps,l=Ol.current,o=!1;return(r=0!=(64&t.flags))||(r=(null===e||null!==e.memoizedState)&&0!=(2&l)),r?(o=!0,t.flags&=-65):null!==e&&null===e.memoizedState||void 0===a.fallback||!0===a.unstable_avoidThisFallback||(l|=1),ia(Ol,1&l),null===e?(void 0!==a.fallback&&Ql(t),e=a.children,l=a.fallback,o?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,e):"number"==typeof a.unstable_expectedLoadTime?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,t.lanes=33554432,e):((n=Vu({mode:"visible",children:e},t.mode,n,null)).return=t,t.child=n)):(e.memoizedState,o?(a=function(e,t,n,r,a){var l=t.mode,o=e.child;e=o.sibling;var i={mode:"hidden",children:n};return 0==(2&l)&&t.child!==o?((n=t.child).childLanes=0,n.pendingProps=i,null!==(o=n.lastEffect)?(t.firstEffect=n.firstEffect,t.lastEffect=o,o.nextEffect=null):t.firstEffect=t.lastEffect=null):n=Qu(o,i),null!==e?r=Qu(e,r):(r=Fu(r,l,a,null)).flags|=2,r.return=t,n.return=t,n.sibling=r,t.child=n,r}(e,t,a.children,a.fallback,n),o=t.child,l=e.child.memoizedState,o.memoizedState=null===l?{baseLanes:n}:{baseLanes:l.baseLanes|n},o.childLanes=e.childLanes&~n,t.memoizedState=Ko,a):(n=function(e,t,n,r){var a=e.child;return e=a.sibling,n=Qu(a,{mode:"visible",children:n}),0==(2&t.mode)&&(n.lanes=r),n.return=t,n.sibling=null,null!==e&&(e.nextEffect=null,e.flags=8,t.firstEffect=t.lastEffect=e),t.child=n}(e,t,a.children,n),t.memoizedState=null,n))}function $o(e,t,n,r){var a=e.mode,l=e.child;return t={mode:"hidden",children:t},0==(2&a)&&null!==l?(l.childLanes=0,l.pendingProps=t):l=Vu(t,a,0,null),n=Fu(n,a,r,null),l.return=e,n.return=e,l.sibling=n,e.child=l,n}function qo(e,t){e.lanes|=t;var n=e.alternate;null!==n&&(n.lanes|=t),el(e.return,t)}function Zo(e,t,n,r,a,l){var o=e.memoizedState;null===o?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:r,tail:n,tailMode:a,lastEffect:l}:(o.isBackwards=t,o.rendering=null,o.renderingStartTime=0,o.last=r,o.tail=n,o.tailMode=a,o.lastEffect=l)}function Xo(e,t,n){var r=t.pendingProps,a=r.revealOrder,l=r.tail;if(zo(e,t,r.children,n),0!=(2&(r=Ol.current)))r=1&r|2,t.flags|=64;else{if(null!==e&&0!=(64&e.flags))e:for(e=t.child;null!==e;){if(13===e.tag)null!==e.memoizedState&&qo(e,n);else if(19===e.tag)qo(e,n);else if(null!==e.child){e.child.return=e,e=e.child;continue}if(e===t)break e;for(;null===e.sibling;){if(null===e.return||e.return===t)break e;e=e.return}e.sibling.return=e.return,e=e.sibling}r&=1}if(ia(Ol,r),0==(2&t.mode))t.memoizedState=null;else switch(a){case"forwards":for(n=t.child,a=null;null!==n;)null!==(e=n.alternate)&&null===zl(e)&&(a=n),n=n.sibling;null===(n=a)?(a=t.child,t.child=null):(a=n.sibling,n.sibling=null),Zo(t,!1,a,n,l,t.lastEffect);break;case"backwards":for(n=null,a=t.child,t.child=null;null!==a;){if(null!==(e=a.alternate)&&null===zl(e)){t.child=a;break}e=a.sibling,a.sibling=n,n=a,a=e}Zo(t,!0,n,null,l,t.lastEffect);break;case"together":Zo(t,!1,null,null,void 0,t.lastEffect);break;default:t.memoizedState=null}return t.child}function Jo(e,t,n){if(null!==e&&(t.dependencies=e.dependencies),Ai|=t.lanes,0!=(n&t.childLanes)){if(null!==e&&t.child!==e.child)throw Error(o(153));if(null!==t.child){for(n=Qu(e=t.child,e.pendingProps),t.child=n,n.return=t;null!==e.sibling;)e=e.sibling,(n=n.sibling=Qu(e,e.pendingProps)).return=t;n.sibling=null}return t.child}return null}function ei(e,t){if(!Pl)switch(e.tailMode){case"hidden":t=e.tail;for(var n=null;null!==t;)null!==t.alternate&&(n=t),t=t.sibling;null===n?e.tail=null:n.sibling=null;break;case"collapsed":n=e.tail;for(var r=null;null!==n;)null!==n.alternate&&(r=n),n=n.sibling;null===r?t||null===e.tail?e.tail=null:e.tail.sibling=null:r.sibling=null}}function ti(e,t,n){var r=t.pendingProps;switch(t.tag){case 2:case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return null;case 1:return pa(t.type)&&ya(),null;case 3:return Cl(),oa(ca),oa(sa),Wl(),(r=t.stateNode).pendingContext&&(r.context=r.pendingContext,r.pendingContext=null),null!==e&&null!==e.child||(Fl(t)?t.flags|=4:r.hydrate||(t.flags|=256)),null;case 5:Dl(t);var l=jl(kl.current);if(n=t.type,null!==e&&null!=t.stateNode)Wo(e,t,n,r),e.ref!==t.ref&&(t.flags|=128);else{if(!r){if(null===t.stateNode)throw Error(o(166));return null}if(e=jl(Sl.current),Fl(t)){r=t.stateNode,n=t.type;var i=t.memoizedProps;switch(r[Gr]=t,r[$r]=i,n){case"dialog":xr("cancel",r),xr("close",r);break;case"iframe":case"object":case"embed":xr("load",r);break;case"video":case"audio":for(e=0;e<Lr.length;e++)xr(Lr[e],r);break;case"source":xr("error",r);break;case"img":case"image":case"link":xr("error",r),xr("load",r);break;case"details":xr("toggle",r);break;case"input":ee(r,i),xr("invalid",r);break;case"select":r._wrapperState={wasMultiple:!!i.multiple},xr("invalid",r);break;case"textarea":ue(r,i),xr("invalid",r)}for(var s in Ne(n,i),e=null,i)i.hasOwnProperty(s)&&(l=i[s],"children"===s?"string"==typeof l?r.textContent!==l&&(e=["children",l]):"number"==typeof l&&r.textContent!==""+l&&(e=["children",""+l]):u.hasOwnProperty(s)&&null!=l&&"onScroll"===s&&xr("scroll",r));switch(n){case"input":q(r),re(r,i,!0);break;case"textarea":q(r),ce(r);break;case"select":case"option":break;default:"function"==typeof i.onClick&&(r.onclick=_r)}r=e,t.updateQueue=r,null!==r&&(t.flags|=4)}else{switch(s=9===l.nodeType?l:l.ownerDocument,e===fe&&(e=de(n)),e===fe?"script"===n?((e=s.createElement("div")).innerHTML="<script><\/script>",e=e.removeChild(e.firstChild)):"string"==typeof r.is?e=s.createElement(n,{is:r.is}):(e=s.createElement(n),"select"===n&&(s=e,r.multiple?s.multiple=!0:r.size&&(s.size=r.size))):e=s.createElementNS(e,n),e[Gr]=t,e[$r]=r,Bo(e,t),t.stateNode=e,s=we(n,r),n){case"dialog":xr("cancel",e),xr("close",e),l=r;break;case"iframe":case"object":case"embed":xr("load",e),l=r;break;case"video":case"audio":for(l=0;l<Lr.length;l++)xr(Lr[l],e);l=r;break;case"source":xr("error",e),l=r;break;case"img":case"image":case"link":xr("error",e),xr("load",e),l=r;break;case"details":xr("toggle",e),l=r;break;case"input":ee(e,r),l=J(e,r),xr("invalid",e);break;case"option":l=le(e,r);break;case"select":e._wrapperState={wasMultiple:!!r.multiple},l=a({},r,{value:void 0}),xr("invalid",e);break;case"textarea":ue(e,r),l=ie(e,r),xr("invalid",e);break;default:l=r}Ne(n,l);var c=l;for(i in c)if(c.hasOwnProperty(i)){var f=c[i];"style"===i?Ee(e,f):"dangerouslySetInnerHTML"===i?null!=(f=f?f.__html:void 0)&&ge(e,f):"children"===i?"string"==typeof f?("textarea"!==n||""!==f)&&me(e,f):"number"==typeof f&&me(e,""+f):"suppressContentEditableWarning"!==i&&"suppressHydrationWarning"!==i&&"autoFocus"!==i&&(u.hasOwnProperty(i)?null!=f&&"onScroll"===i&&xr("scroll",e):null!=f&&M(e,i,f,s))}switch(n){case"input":q(e),re(e,r,!1);break;case"textarea":q(e),ce(e);break;case"option":null!=r.value&&e.setAttribute("value",""+G(r.value));break;case"select":e.multiple=!!r.multiple,null!=(i=r.value)?oe(e,!!r.multiple,i,!1):null!=r.defaultValue&&oe(e,!!r.multiple,r.defaultValue,!0);break;default:"function"==typeof l.onClick&&(e.onclick=_r)}Yr(n,r)&&(t.flags|=4)}null!==t.ref&&(t.flags|=128)}return null;case 6:if(e&&null!=t.stateNode)Ho(0,t,e.memoizedProps,r);else{if("string"!=typeof r&&null===t.stateNode)throw Error(o(166));n=jl(kl.current),jl(Sl.current),Fl(t)?(r=t.stateNode,n=t.memoizedProps,r[Gr]=t,r.nodeValue!==n&&(t.flags|=4)):((r=(9===n.nodeType?n:n.ownerDocument).createTextNode(r))[Gr]=t,t.stateNode=r)}return null;case 13:return oa(Ol),r=t.memoizedState,0!=(64&t.flags)?(t.lanes=n,t):(r=null!==r,n=!1,null===e?void 0!==t.memoizedProps.fallback&&Fl(t):n=null!==e.memoizedState,r&&!n&&0!=(2&t.mode)&&(null===e&&!0!==t.memoizedProps.unstable_avoidThisFallback||0!=(1&Ol.current)?0===Di&&(Di=3):(0!==Di&&3!==Di||(Di=4),null===ki||0==(134217727&Ai)&&0==(134217727&_i)||du(ki,Ti))),(r||n)&&(t.flags|=4),null);case 4:return Cl(),null===e&&jr(t.stateNode.containerInfo),null;case 10:return Ja(t),null;case 17:return pa(t.type)&&ya(),null;case 19:if(oa(Ol),null===(r=t.memoizedState))return null;if(i=0!=(64&t.flags),null===(s=r.rendering))if(i)ei(r,!1);else{if(0!==Di||null!==e&&0!=(64&e.flags))for(e=t.child;null!==e;){if(null!==(s=zl(e))){for(t.flags|=64,ei(r,!1),null!==(i=s.updateQueue)&&(t.updateQueue=i,t.flags|=4),null===r.lastEffect&&(t.firstEffect=null),t.lastEffect=r.lastEffect,r=n,n=t.child;null!==n;)e=r,(i=n).flags&=2,i.nextEffect=null,i.firstEffect=null,i.lastEffect=null,null===(s=i.alternate)?(i.childLanes=0,i.lanes=e,i.child=null,i.memoizedProps=null,i.memoizedState=null,i.updateQueue=null,i.dependencies=null,i.stateNode=null):(i.childLanes=s.childLanes,i.lanes=s.lanes,i.child=s.child,i.memoizedProps=s.memoizedProps,i.memoizedState=s.memoizedState,i.updateQueue=s.updateQueue,i.type=s.type,e=s.dependencies,i.dependencies=null===e?null:{lanes:e.lanes,firstContext:e.firstContext}),n=n.sibling;return ia(Ol,1&Ol.current|2),t.child}e=e.sibling}null!==r.tail&&Ya()>Qi&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432)}else{if(!i)if(null!==(e=zl(s))){if(t.flags|=64,i=!0,null!==(n=e.updateQueue)&&(t.updateQueue=n,t.flags|=4),ei(r,!0),null===r.tail&&"hidden"===r.tailMode&&!s.alternate&&!Pl)return null!==(t=t.lastEffect=r.lastEffect)&&(t.nextEffect=null),null}else 2*Ya()-r.renderingStartTime>Qi&&1073741824!==n&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432);r.isBackwards?(s.sibling=t.child,t.child=s):(null!==(n=r.last)?n.sibling=s:t.child=s,r.last=s)}return null!==r.tail?(n=r.tail,r.rendering=n,r.tail=n.sibling,r.lastEffect=t.lastEffect,r.renderingStartTime=Ya(),n.sibling=null,t=Ol.current,ia(Ol,i?1&t|2:1&t),n):null;case 23:case 24:return mu(),null!==e&&null!==e.memoizedState!=(null!==t.memoizedState)&&"unstable-defer-without-hiding"!==r.mode&&(t.flags|=4),null}throw Error(o(156,t.tag))}function ni(e){switch(e.tag){case 1:pa(e.type)&&ya();var t=e.flags;return 4096&t?(e.flags=-4097&t|64,e):null;case 3:if(Cl(),oa(ca),oa(sa),Wl(),0!=(64&(t=e.flags)))throw Error(o(285));return e.flags=-4097&t|64,e;case 5:return Dl(e),null;case 13:return oa(Ol),4096&(t=e.flags)?(e.flags=-4097&t|64,e):null;case 19:return oa(Ol),null;case 4:return Cl(),null;case 10:return Ja(e),null;case 23:case 24:return mu(),null;default:return null}}function ri(e,t){try{var n="",r=t;do{n+=H(r),r=r.return}while(r);var a=n}catch(e){a="\nError generating stack: "+e.message+"\n"+e.stack}return{value:e,source:t,stack:a}}function ai(e,t){try{console.error(t.value)}catch(e){setTimeout((function(){throw e}))}}Bo=function(e,t){for(var n=t.child;null!==n;){if(5===n.tag||6===n.tag)e.appendChild(n.stateNode);else if(4!==n.tag&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===t)break;for(;null===n.sibling;){if(null===n.return||n.return===t)return;n=n.return}n.sibling.return=n.return,n=n.sibling}},Wo=function(e,t,n,r){var l=e.memoizedProps;if(l!==r){e=t.stateNode,jl(Sl.current);var o,i=null;switch(n){case"input":l=J(e,l),r=J(e,r),i=[];break;case"option":l=le(e,l),r=le(e,r),i=[];break;case"select":l=a({},l,{value:void 0}),r=a({},r,{value:void 0}),i=[];break;case"textarea":l=ie(e,l),r=ie(e,r),i=[];break;default:"function"!=typeof l.onClick&&"function"==typeof r.onClick&&(e.onclick=_r)}for(f in Ne(n,r),n=null,l)if(!r.hasOwnProperty(f)&&l.hasOwnProperty(f)&&null!=l[f])if("style"===f){var s=l[f];for(o in s)s.hasOwnProperty(o)&&(n||(n={}),n[o]="")}else"dangerouslySetInnerHTML"!==f&&"children"!==f&&"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&"autoFocus"!==f&&(u.hasOwnProperty(f)?i||(i=[]):(i=i||[]).push(f,null));for(f in r){var c=r[f];if(s=null!=l?l[f]:void 0,r.hasOwnProperty(f)&&c!==s&&(null!=c||null!=s))if("style"===f)if(s){for(o in s)!s.hasOwnProperty(o)||c&&c.hasOwnProperty(o)||(n||(n={}),n[o]="");for(o in c)c.hasOwnProperty(o)&&s[o]!==c[o]&&(n||(n={}),n[o]=c[o])}else n||(i||(i=[]),i.push(f,n)),n=c;else"dangerouslySetInnerHTML"===f?(c=c?c.__html:void 0,s=s?s.__html:void 0,null!=c&&s!==c&&(i=i||[]).push(f,c)):"children"===f?"string"!=typeof c&&"number"!=typeof c||(i=i||[]).push(f,""+c):"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&(u.hasOwnProperty(f)?(null!=c&&"onScroll"===f&&xr("scroll",e),i||s===c||(i=[])):"object"==typeof c&&null!==c&&c.$$typeof===A?c.toString():(i=i||[]).push(f,c))}n&&(i=i||[]).push("style",n);var f=i;(t.updateQueue=f)&&(t.flags|=4)}},Ho=function(e,t,n,r){n!==r&&(t.flags|=4)};var li="function"==typeof WeakMap?WeakMap:Map;function oi(e,t,n){(n=ol(-1,n)).tag=3,n.payload={element:null};var r=t.value;return n.callback=function(){Bi||(Bi=!0,Wi=r),ai(0,t)},n}function ii(e,t,n){(n=ol(-1,n)).tag=3;var r=e.type.getDerivedStateFromError;if("function"==typeof r){var a=t.value;n.payload=function(){return ai(0,t),r(a)}}var l=e.stateNode;return null!==l&&"function"==typeof l.componentDidCatch&&(n.callback=function(){"function"!=typeof r&&(null===Hi?Hi=new Set([this]):Hi.add(this),ai(0,t));var e=t.stack;this.componentDidCatch(t.value,{componentStack:null!==e?e:""})}),n}var ui="function"==typeof WeakSet?WeakSet:Set;function si(e){var t=e.ref;if(null!==t)if("function"==typeof t)try{t(null)}catch(t){zu(e,t)}else t.current=null}function ci(e,t){switch(t.tag){case 0:case 11:case 15:case 22:return;case 1:if(256&t.flags&&null!==e){var n=e.memoizedProps,r=e.memoizedState;t=(e=t.stateNode).getSnapshotBeforeUpdate(t.elementType===t.type?n:Ka(t.type,n),r),e.__reactInternalSnapshotBeforeUpdate=t}return;case 3:return void(256&t.flags&&Vr(t.stateNode.containerInfo));case 5:case 6:case 4:case 17:return}throw Error(o(163))}function fi(e,t,n){switch(n.tag){case 0:case 11:case 15:case 22:if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{if(3==(3&e.tag)){var r=e.create;e.destroy=r()}e=e.next}while(e!==t)}if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{var a=e;r=a.next,0!=(4&(a=a.tag))&&0!=(1&a)&&(Iu(n,e),Cu(n,e)),e=r}while(e!==t)}return;case 1:return e=n.stateNode,4&n.flags&&(null===t?e.componentDidMount():(r=n.elementType===n.type?t.memoizedProps:Ka(n.type,t.memoizedProps),e.componentDidUpdate(r,t.memoizedState,e.__reactInternalSnapshotBeforeUpdate))),void(null!==(t=n.updateQueue)&&cl(n,t,e));case 3:if(null!==(t=n.updateQueue)){if(e=null,null!==n.child)switch(n.child.tag){case 5:e=n.child.stateNode;break;case 1:e=n.child.stateNode}cl(n,t,e)}return;case 5:return e=n.stateNode,void(null===t&&4&n.flags&&Yr(n.type,n.memoizedProps)&&e.focus());case 6:case 4:case 12:return;case 13:return void(null===n.memoizedState&&(n=n.alternate,null!==n&&(n=n.memoizedState,null!==n&&(n=n.dehydrated,null!==n&&Et(n)))));case 19:case 17:case 20:case 21:case 23:case 24:return}throw Error(o(163))}function di(e,t){for(var n=e;;){if(5===n.tag){var r=n.stateNode;if(t)"function"==typeof(r=r.style).setProperty?r.setProperty("display","none","important"):r.display="none";else{r=n.stateNode;var a=n.memoizedProps.style;a=null!=a&&a.hasOwnProperty("display")?a.display:null,r.style.display=Me("display",a)}}else if(6===n.tag)n.stateNode.nodeValue=t?"":n.memoizedProps;else if((23!==n.tag&&24!==n.tag||null===n.memoizedState||n===e)&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===e)break;for(;null===n.sibling;){if(null===n.return||n.return===e)return;n=n.return}n.sibling.return=n.return,n=n.sibling}}function pi(e,t){if(Ma&&"function"==typeof Ma.onCommitFiberUnmount)try{Ma.onCommitFiberUnmount(ba,t)}catch(e){}switch(t.tag){case 0:case 11:case 14:case 15:case 22:if(null!==(e=t.updateQueue)&&null!==(e=e.lastEffect)){var n=e=e.next;do{var r=n,a=r.destroy;if(r=r.tag,void 0!==a)if(0!=(4&r))Iu(t,n);else{r=t;try{a()}catch(e){zu(r,e)}}n=n.next}while(n!==e)}break;case 1:if(si(t),"function"==typeof(e=t.stateNode).componentWillUnmount)try{e.props=t.memoizedProps,e.state=t.memoizedState,e.componentWillUnmount()}catch(e){zu(t,e)}break;case 5:si(t);break;case 4:bi(e,t)}}function yi(e){e.alternate=null,e.child=null,e.dependencies=null,e.firstEffect=null,e.lastEffect=null,e.memoizedProps=null,e.memoizedState=null,e.pendingProps=null,e.return=null,e.updateQueue=null}function hi(e){return 5===e.tag||3===e.tag||4===e.tag}function gi(e){e:{for(var t=e.return;null!==t;){if(hi(t))break e;t=t.return}throw Error(o(160))}var n=t;switch(t=n.stateNode,n.tag){case 5:var r=!1;break;case 3:case 4:t=t.containerInfo,r=!0;break;default:throw Error(o(161))}16&n.flags&&(me(t,""),n.flags&=-17);e:t:for(n=e;;){for(;null===n.sibling;){if(null===n.return||hi(n.return)){n=null;break e}n=n.return}for(n.sibling.return=n.return,n=n.sibling;5!==n.tag&&6!==n.tag&&18!==n.tag;){if(2&n.flags)continue t;if(null===n.child||4===n.tag)continue t;n.child.return=n,n=n.child}if(!(2&n.flags)){n=n.stateNode;break e}}r?mi(e,n,t):vi(e,n,t)}function mi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?8===n.nodeType?n.parentNode.insertBefore(e,t):n.insertBefore(e,t):(8===n.nodeType?(t=n.parentNode).insertBefore(e,n):(t=n).appendChild(e),null!=(n=n._reactRootContainer)||null!==t.onclick||(t.onclick=_r));else if(4!==r&&null!==(e=e.child))for(mi(e,t,n),e=e.sibling;null!==e;)mi(e,t,n),e=e.sibling}function vi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?n.insertBefore(e,t):n.appendChild(e);else if(4!==r&&null!==(e=e.child))for(vi(e,t,n),e=e.sibling;null!==e;)vi(e,t,n),e=e.sibling}function bi(e,t){for(var n,r,a=t,l=!1;;){if(!l){l=a.return;e:for(;;){if(null===l)throw Error(o(160));switch(n=l.stateNode,l.tag){case 5:r=!1;break e;case 3:case 4:n=n.containerInfo,r=!0;break e}l=l.return}l=!0}if(5===a.tag||6===a.tag){e:for(var i=e,u=a,s=u;;)if(pi(i,s),null!==s.child&&4!==s.tag)s.child.return=s,s=s.child;else{if(s===u)break e;for(;null===s.sibling;){if(null===s.return||s.return===u)break e;s=s.return}s.sibling.return=s.return,s=s.sibling}r?(i=n,u=a.stateNode,8===i.nodeType?i.parentNode.removeChild(u):i.removeChild(u)):n.removeChild(a.stateNode)}else if(4===a.tag){if(null!==a.child){n=a.stateNode.containerInfo,r=!0,a.child.return=a,a=a.child;continue}}else if(pi(e,a),null!==a.child){a.child.return=a,a=a.child;continue}if(a===t)break;for(;null===a.sibling;){if(null===a.return||a.return===t)return;4===(a=a.return).tag&&(l=!1)}a.sibling.return=a.return,a=a.sibling}}function Mi(e,t){switch(t.tag){case 0:case 11:case 14:case 15:case 22:var n=t.updateQueue;if(null!==(n=null!==n?n.lastEffect:null)){var r=n=n.next;do{3==(3&r.tag)&&(e=r.destroy,r.destroy=void 0,void 0!==e&&e()),r=r.next}while(r!==n)}return;case 1:return;case 5:if(null!=(n=t.stateNode)){r=t.memoizedProps;var a=null!==e?e.memoizedProps:r;e=t.type;var l=t.updateQueue;if(t.updateQueue=null,null!==l){for(n[$r]=r,"input"===e&&"radio"===r.type&&null!=r.name&&te(n,r),we(e,a),t=we(e,r),a=0;a<l.length;a+=2){var i=l[a],u=l[a+1];"style"===i?Ee(n,u):"dangerouslySetInnerHTML"===i?ge(n,u):"children"===i?me(n,u):M(n,i,u,t)}switch(e){case"input":ne(n,r);break;case"textarea":se(n,r);break;case"select":e=n._wrapperState.wasMultiple,n._wrapperState.wasMultiple=!!r.multiple,null!=(l=r.value)?oe(n,!!r.multiple,l,!1):e!==!!r.multiple&&(null!=r.defaultValue?oe(n,!!r.multiple,r.defaultValue,!0):oe(n,!!r.multiple,r.multiple?[]:"",!1))}}}return;case 6:if(null===t.stateNode)throw Error(o(162));return void(t.stateNode.nodeValue=t.memoizedProps);case 3:return void((n=t.stateNode).hydrate&&(n.hydrate=!1,Et(n.containerInfo)));case 12:return;case 13:return null!==t.memoizedState&&(Yi=Ya(),di(t.child,!0)),void Ei(t);case 19:return void Ei(t);case 17:return;case 23:case 24:return void di(t,null!==t.memoizedState)}throw Error(o(163))}function Ei(e){var t=e.updateQueue;if(null!==t){e.updateQueue=null;var n=e.stateNode;null===n&&(n=e.stateNode=new ui),t.forEach((function(t){var r=_u.bind(null,e,t);n.has(t)||(n.add(t),t.then(r,r))}))}}function Li(e,t){return null!==e&&(null===(e=e.memoizedState)||null!==e.dehydrated)&&null!==(t=t.memoizedState)&&null===t.dehydrated}var Ni=Math.ceil,wi=E.ReactCurrentDispatcher,Si=E.ReactCurrentOwner,xi=0,ki=null,ji=null,Ti=0,Ci=0,Ii=la(0),Di=0,Oi=null,zi=0,Ai=0,_i=0,Pi=0,Ui=null,Yi=0,Qi=1/0;function Ri(){Qi=Ya()+500}var Fi,Vi=null,Bi=!1,Wi=null,Hi=null,Ki=!1,Gi=null,$i=90,qi=[],Zi=[],Xi=null,Ji=0,eu=null,tu=-1,nu=0,ru=0,au=null,lu=!1;function ou(){return 0!=(48&xi)?Ya():-1!==tu?tu:tu=Ya()}function iu(e){if(0==(2&(e=e.mode)))return 1;if(0==(4&e))return 99===Qa()?1:2;if(0===nu&&(nu=zi),0!==Ha.transition){0!==ru&&(ru=null!==Ui?Ui.pendingLanes:0),e=nu;var t=4186112&~ru;return 0==(t&=-t)&&0==(t=(e=4186112&~e)&-e)&&(t=8192),t}return e=Qa(),e=Yt(0!=(4&xi)&&98===e?12:e=function(e){switch(e){case 99:return 15;case 98:return 10;case 97:case 96:return 8;case 95:return 2;default:return 0}}(e),nu)}function uu(e,t,n){if(50<Ji)throw Ji=0,eu=null,Error(o(185));if(null===(e=su(e,t)))return null;Ft(e,t,n),e===ki&&(_i|=t,4===Di&&du(e,Ti));var r=Qa();1===t?0!=(8&xi)&&0==(48&xi)?pu(e):(cu(e,n),0===xi&&(Ri(),Ba())):(0==(4&xi)||98!==r&&99!==r||(null===Xi?Xi=new Set([e]):Xi.add(e)),cu(e,n)),Ui=e}function su(e,t){e.lanes|=t;var n=e.alternate;for(null!==n&&(n.lanes|=t),n=e,e=e.return;null!==e;)e.childLanes|=t,null!==(n=e.alternate)&&(n.childLanes|=t),n=e,e=e.return;return 3===n.tag?n.stateNode:null}function cu(e,t){for(var n=e.callbackNode,r=e.suspendedLanes,a=e.pingedLanes,l=e.expirationTimes,i=e.pendingLanes;0<i;){var u=31-Vt(i),s=1<<u,c=l[u];if(-1===c){if(0==(s&r)||0!=(s&a)){c=t,_t(s);var f=At;l[u]=10<=f?c+250:6<=f?c+5e3:-1}}else c<=t&&(e.expiredLanes|=s);i&=~s}if(r=Pt(e,e===ki?Ti:0),t=At,0===r)null!==n&&(n!==Oa&&Na(n),e.callbackNode=null,e.callbackPriority=0);else{if(null!==n){if(e.callbackPriority===t)return;n!==Oa&&Na(n)}15===t?(n=pu.bind(null,e),null===Aa?(Aa=[n],_a=La(ja,Wa)):Aa.push(n),n=Oa):n=14===t?Va(99,pu.bind(null,e)):Va(n=function(e){switch(e){case 15:case 14:return 99;case 13:case 12:case 11:case 10:return 98;case 9:case 8:case 7:case 6:case 4:case 5:return 97;case 3:case 2:case 1:return 95;case 0:return 90;default:throw Error(o(358,e))}}(t),fu.bind(null,e)),e.callbackPriority=t,e.callbackNode=n}}function fu(e){if(tu=-1,ru=nu=0,0!=(48&xi))throw Error(o(327));var t=e.callbackNode;if(Tu()&&e.callbackNode!==t)return null;var n=Pt(e,e===ki?Ti:0);if(0===n)return null;var r=n,a=xi;xi|=16;var l=Mu();for(ki===e&&Ti===r||(Ri(),vu(e,r));;)try{Nu();break}catch(t){bu(e,t)}if(Xa(),wi.current=l,xi=a,null!==ji?r=0:(ki=null,Ti=0,r=Di),0!=(zi&_i))vu(e,0);else if(0!==r){if(2===r&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(n=Ut(e))&&(r=Eu(e,n))),1===r)throw t=Oi,vu(e,0),du(e,n),cu(e,Ya()),t;switch(e.finishedWork=e.current.alternate,e.finishedLanes=n,r){case 0:case 1:throw Error(o(345));case 2:xu(e);break;case 3:if(du(e,n),(62914560&n)===n&&10<(r=Yi+500-Ya())){if(0!==Pt(e,0))break;if(((a=e.suspendedLanes)&n)!==n){ou(),e.pingedLanes|=e.suspendedLanes&a;break}e.timeoutHandle=Rr(xu.bind(null,e),r);break}xu(e);break;case 4:if(du(e,n),(4186112&n)===n)break;for(r=e.eventTimes,a=-1;0<n;){var i=31-Vt(n);l=1<<i,(i=r[i])>a&&(a=i),n&=~l}if(n=a,10<(n=(120>(n=Ya()-n)?120:480>n?480:1080>n?1080:1920>n?1920:3e3>n?3e3:4320>n?4320:1960*Ni(n/1960))-n)){e.timeoutHandle=Rr(xu.bind(null,e),n);break}xu(e);break;case 5:xu(e);break;default:throw Error(o(329))}}return cu(e,Ya()),e.callbackNode===t?fu.bind(null,e):null}function du(e,t){for(t&=~Pi,t&=~_i,e.suspendedLanes|=t,e.pingedLanes&=~t,e=e.expirationTimes;0<t;){var n=31-Vt(t),r=1<<n;e[n]=-1,t&=~r}}function pu(e){if(0!=(48&xi))throw Error(o(327));if(Tu(),e===ki&&0!=(e.expiredLanes&Ti)){var t=Ti,n=Eu(e,t);0!=(zi&_i)&&(n=Eu(e,t=Pt(e,t)))}else n=Eu(e,t=Pt(e,0));if(0!==e.tag&&2===n&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(t=Ut(e))&&(n=Eu(e,t))),1===n)throw n=Oi,vu(e,0),du(e,t),cu(e,Ya()),n;return e.finishedWork=e.current.alternate,e.finishedLanes=t,xu(e),cu(e,Ya()),null}function yu(e,t){var n=xi;xi|=1;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function hu(e,t){var n=xi;xi&=-2,xi|=8;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function gu(e,t){ia(Ii,Ci),Ci|=t,zi|=t}function mu(){Ci=Ii.current,oa(Ii)}function vu(e,t){e.finishedWork=null,e.finishedLanes=0;var n=e.timeoutHandle;if(-1!==n&&(e.timeoutHandle=-1,Fr(n)),null!==ji)for(n=ji.return;null!==n;){var r=n;switch(r.tag){case 1:null!=(r=r.type.childContextTypes)&&ya();break;case 3:Cl(),oa(ca),oa(sa),Wl();break;case 5:Dl(r);break;case 4:Cl();break;case 13:case 19:oa(Ol);break;case 10:Ja(r);break;case 23:case 24:mu()}n=n.return}ki=e,ji=Qu(e.current,null),Ti=Ci=zi=t,Di=0,Oi=null,Pi=_i=Ai=0}function bu(e,t){for(;;){var n=ji;try{if(Xa(),Hl.current=jo,Xl){for(var r=$l.memoizedState;null!==r;){var a=r.queue;null!==a&&(a.pending=null),r=r.next}Xl=!1}if(Gl=0,Zl=ql=$l=null,Jl=!1,Si.current=null,null===n||null===n.return){Di=1,Oi=t,ji=null;break}e:{var l=e,o=n.return,i=n,u=t;if(t=Ti,i.flags|=2048,i.firstEffect=i.lastEffect=null,null!==u&&"object"==typeof u&&"function"==typeof u.then){var s=u;if(0==(2&i.mode)){var c=i.alternate;c?(i.updateQueue=c.updateQueue,i.memoizedState=c.memoizedState,i.lanes=c.lanes):(i.updateQueue=null,i.memoizedState=null)}var f=0!=(1&Ol.current),d=o;do{var p;if(p=13===d.tag){var y=d.memoizedState;if(null!==y)p=null!==y.dehydrated;else{var h=d.memoizedProps;p=void 0!==h.fallback&&(!0!==h.unstable_avoidThisFallback||!f)}}if(p){var g=d.updateQueue;if(null===g){var m=new Set;m.add(s),d.updateQueue=m}else g.add(s);if(0==(2&d.mode)){if(d.flags|=64,i.flags|=16384,i.flags&=-2981,1===i.tag)if(null===i.alternate)i.tag=17;else{var v=ol(-1,1);v.tag=2,il(i,v)}i.lanes|=1;break e}u=void 0,i=t;var b=l.pingCache;if(null===b?(b=l.pingCache=new li,u=new Set,b.set(s,u)):void 0===(u=b.get(s))&&(u=new Set,b.set(s,u)),!u.has(i)){u.add(i);var M=Au.bind(null,l,s,i);s.then(M,M)}d.flags|=4096,d.lanes=t;break e}d=d.return}while(null!==d);u=Error((K(i.type)||"A React component")+" suspended while rendering, but no fallback UI was specified.\n\nAdd a <Suspense fallback=...> component higher in the tree to provide a loading indicator or placeholder to display.")}5!==Di&&(Di=2),u=ri(u,i),d=o;do{switch(d.tag){case 3:l=u,d.flags|=4096,t&=-t,d.lanes|=t,ul(d,oi(0,l,t));break e;case 1:l=u;var E=d.type,L=d.stateNode;if(0==(64&d.flags)&&("function"==typeof E.getDerivedStateFromError||null!==L&&"function"==typeof L.componentDidCatch&&(null===Hi||!Hi.has(L)))){d.flags|=4096,t&=-t,d.lanes|=t,ul(d,ii(d,l,t));break e}}d=d.return}while(null!==d)}Su(n)}catch(e){t=e,ji===n&&null!==n&&(ji=n=n.return);continue}break}}function Mu(){var e=wi.current;return wi.current=jo,null===e?jo:e}function Eu(e,t){var n=xi;xi|=16;var r=Mu();for(ki===e&&Ti===t||vu(e,t);;)try{Lu();break}catch(t){bu(e,t)}if(Xa(),xi=n,wi.current=r,null!==ji)throw Error(o(261));return ki=null,Ti=0,Di}function Lu(){for(;null!==ji;)wu(ji)}function Nu(){for(;null!==ji&&!wa();)wu(ji)}function wu(e){var t=Fi(e.alternate,e,Ci);e.memoizedProps=e.pendingProps,null===t?Su(e):ji=t,Si.current=null}function Su(e){var t=e;do{var n=t.alternate;if(e=t.return,0==(2048&t.flags)){if(null!==(n=ti(n,t,Ci)))return void(ji=n);if(24!==(n=t).tag&&23!==n.tag||null===n.memoizedState||0!=(1073741824&Ci)||0==(4&n.mode)){for(var r=0,a=n.child;null!==a;)r|=a.lanes|a.childLanes,a=a.sibling;n.childLanes=r}null!==e&&0==(2048&e.flags)&&(null===e.firstEffect&&(e.firstEffect=t.firstEffect),null!==t.lastEffect&&(null!==e.lastEffect&&(e.lastEffect.nextEffect=t.firstEffect),e.lastEffect=t.lastEffect),1<t.flags&&(null!==e.lastEffect?e.lastEffect.nextEffect=t:e.firstEffect=t,e.lastEffect=t))}else{if(null!==(n=ni(t)))return n.flags&=2047,void(ji=n);null!==e&&(e.firstEffect=e.lastEffect=null,e.flags|=2048)}if(null!==(t=t.sibling))return void(ji=t);ji=t=e}while(null!==t);0===Di&&(Di=5)}function xu(e){var t=Qa();return Fa(99,ku.bind(null,e,t)),null}function ku(e,t){do{Tu()}while(null!==Gi);if(0!=(48&xi))throw Error(o(327));var n=e.finishedWork;if(null===n)return null;if(e.finishedWork=null,e.finishedLanes=0,n===e.current)throw Error(o(177));e.callbackNode=null;var r=n.lanes|n.childLanes,a=r,l=e.pendingLanes&~a;e.pendingLanes=a,e.suspendedLanes=0,e.pingedLanes=0,e.expiredLanes&=a,e.mutableReadLanes&=a,e.entangledLanes&=a,a=e.entanglements;for(var i=e.eventTimes,u=e.expirationTimes;0<l;){var s=31-Vt(l),c=1<<s;a[s]=0,i[s]=-1,u[s]=-1,l&=~c}if(null!==Xi&&0==(24&r)&&Xi.has(e)&&Xi.delete(e),e===ki&&(ji=ki=null,Ti=0),1<n.flags?null!==n.lastEffect?(n.lastEffect.nextEffect=n,r=n.firstEffect):r=n:r=n.firstEffect,null!==r){if(a=xi,xi|=32,Si.current=null,Pr=Gt,pr(i=dr())){if("selectionStart"in i)u={start:i.selectionStart,end:i.selectionEnd};else e:if(u=(u=i.ownerDocument)&&u.defaultView||window,(c=u.getSelection&&u.getSelection())&&0!==c.rangeCount){u=c.anchorNode,l=c.anchorOffset,s=c.focusNode,c=c.focusOffset;try{u.nodeType,s.nodeType}catch(e){u=null;break e}var f=0,d=-1,p=-1,y=0,h=0,g=i,m=null;t:for(;;){for(var v;g!==u||0!==l&&3!==g.nodeType||(d=f+l),g!==s||0!==c&&3!==g.nodeType||(p=f+c),3===g.nodeType&&(f+=g.nodeValue.length),null!==(v=g.firstChild);)m=g,g=v;for(;;){if(g===i)break t;if(m===u&&++y===l&&(d=f),m===s&&++h===c&&(p=f),null!==(v=g.nextSibling))break;m=(g=m).parentNode}g=v}u=-1===d||-1===p?null:{start:d,end:p}}else u=null;u=u||{start:0,end:0}}else u=null;Ur={focusedElem:i,selectionRange:u},Gt=!1,au=null,lu=!1,Vi=r;do{try{ju()}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);au=null,Vi=r;do{try{for(i=e;null!==Vi;){var b=Vi.flags;if(16&b&&me(Vi.stateNode,""),128&b){var M=Vi.alternate;if(null!==M){var E=M.ref;null!==E&&("function"==typeof E?E(null):E.current=null)}}switch(1038&b){case 2:gi(Vi),Vi.flags&=-3;break;case 6:gi(Vi),Vi.flags&=-3,Mi(Vi.alternate,Vi);break;case 1024:Vi.flags&=-1025;break;case 1028:Vi.flags&=-1025,Mi(Vi.alternate,Vi);break;case 4:Mi(Vi.alternate,Vi);break;case 8:bi(i,u=Vi);var L=u.alternate;yi(u),null!==L&&yi(L)}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);if(E=Ur,M=dr(),b=E.focusedElem,i=E.selectionRange,M!==b&&b&&b.ownerDocument&&fr(b.ownerDocument.documentElement,b)){null!==i&&pr(b)&&(M=i.start,void 0===(E=i.end)&&(E=M),"selectionStart"in b?(b.selectionStart=M,b.selectionEnd=Math.min(E,b.value.length)):(E=(M=b.ownerDocument||document)&&M.defaultView||window).getSelection&&(E=E.getSelection(),u=b.textContent.length,L=Math.min(i.start,u),i=void 0===i.end?L:Math.min(i.end,u),!E.extend&&L>i&&(u=i,i=L,L=u),u=cr(b,L),l=cr(b,i),u&&l&&(1!==E.rangeCount||E.anchorNode!==u.node||E.anchorOffset!==u.offset||E.focusNode!==l.node||E.focusOffset!==l.offset)&&((M=M.createRange()).setStart(u.node,u.offset),E.removeAllRanges(),L>i?(E.addRange(M),E.extend(l.node,l.offset)):(M.setEnd(l.node,l.offset),E.addRange(M))))),M=[];for(E=b;E=E.parentNode;)1===E.nodeType&&M.push({element:E,left:E.scrollLeft,top:E.scrollTop});for("function"==typeof b.focus&&b.focus(),b=0;b<M.length;b++)(E=M[b]).element.scrollLeft=E.left,E.element.scrollTop=E.top}Gt=!!Pr,Ur=Pr=null,e.current=n,Vi=r;do{try{for(b=e;null!==Vi;){var N=Vi.flags;if(36&N&&fi(b,Vi.alternate,Vi),128&N){M=void 0;var w=Vi.ref;if(null!==w){var S=Vi.stateNode;switch(Vi.tag){case 5:M=S;break;default:M=S}"function"==typeof w?w(M):w.current=M}}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);Vi=null,za(),xi=a}else e.current=n;if(Ki)Ki=!1,Gi=e,$i=t;else for(Vi=r;null!==Vi;)t=Vi.nextEffect,Vi.nextEffect=null,8&Vi.flags&&((N=Vi).sibling=null,N.stateNode=null),Vi=t;if(0===(r=e.pendingLanes)&&(Hi=null),1===r?e===eu?Ji++:(Ji=0,eu=e):Ji=0,n=n.stateNode,Ma&&"function"==typeof Ma.onCommitFiberRoot)try{Ma.onCommitFiberRoot(ba,n,void 0,64==(64&n.current.flags))}catch(e){}if(cu(e,Ya()),Bi)throw Bi=!1,e=Wi,Wi=null,e;return 0!=(8&xi)||Ba(),null}function ju(){for(;null!==Vi;){var e=Vi.alternate;lu||null===au||(0!=(8&Vi.flags)?Je(Vi,au)&&(lu=!0):13===Vi.tag&&Li(e,Vi)&&Je(Vi,au)&&(lu=!0));var t=Vi.flags;0!=(256&t)&&ci(e,Vi),0==(512&t)||Ki||(Ki=!0,Va(97,(function(){return Tu(),null}))),Vi=Vi.nextEffect}}function Tu(){if(90!==$i){var e=97<$i?97:$i;return $i=90,Fa(e,Du)}return!1}function Cu(e,t){qi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Iu(e,t){Zi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Du(){if(null===Gi)return!1;var e=Gi;if(Gi=null,0!=(48&xi))throw Error(o(331));var t=xi;xi|=32;var n=Zi;Zi=[];for(var r=0;r<n.length;r+=2){var a=n[r],l=n[r+1],i=a.destroy;if(a.destroy=void 0,"function"==typeof i)try{i()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(n=qi,qi=[],r=0;r<n.length;r+=2){a=n[r],l=n[r+1];try{var u=a.create;a.destroy=u()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(u=e.current.firstEffect;null!==u;)e=u.nextEffect,u.nextEffect=null,8&u.flags&&(u.sibling=null,u.stateNode=null),u=e;return xi=t,Ba(),!0}function Ou(e,t,n){il(e,t=oi(0,t=ri(n,t),1)),t=ou(),null!==(e=su(e,1))&&(Ft(e,1,t),cu(e,t))}function zu(e,t){if(3===e.tag)Ou(e,e,t);else for(var n=e.return;null!==n;){if(3===n.tag){Ou(n,e,t);break}if(1===n.tag){var r=n.stateNode;if("function"==typeof n.type.getDerivedStateFromError||"function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r))){var a=ii(n,e=ri(t,e),1);if(il(n,a),a=ou(),null!==(n=su(n,1)))Ft(n,1,a),cu(n,a);else if("function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r)))try{r.componentDidCatch(t,e)}catch(e){}break}}n=n.return}}function Au(e,t,n){var r=e.pingCache;null!==r&&r.delete(t),t=ou(),e.pingedLanes|=e.suspendedLanes&n,ki===e&&(Ti&n)===n&&(4===Di||3===Di&&(62914560&Ti)===Ti&&500>Ya()-Yi?vu(e,0):Pi|=n),cu(e,t)}function _u(e,t){var n=e.stateNode;null!==n&&n.delete(t),0==(t=0)&&(0==(2&(t=e.mode))?t=1:0==(4&t)?t=99===Qa()?1:2:(0===nu&&(nu=zi),0===(t=Qt(62914560&~nu))&&(t=4194304))),n=ou(),null!==(e=su(e,t))&&(Ft(e,t,n),cu(e,n))}function Pu(e,t,n,r){this.tag=e,this.key=n,this.sibling=this.child=this.return=this.stateNode=this.type=this.elementType=null,this.index=0,this.ref=null,this.pendingProps=t,this.dependencies=this.memoizedState=this.updateQueue=this.memoizedProps=null,this.mode=r,this.flags=0,this.lastEffect=this.firstEffect=this.nextEffect=null,this.childLanes=this.lanes=0,this.alternate=null}function Uu(e,t,n,r){return new Pu(e,t,n,r)}function Yu(e){return!(!(e=e.prototype)||!e.isReactComponent)}function Qu(e,t){var n=e.alternate;return null===n?((n=Uu(e.tag,t,e.key,e.mode)).elementType=e.elementType,n.type=e.type,n.stateNode=e.stateNode,n.alternate=e,e.alternate=n):(n.pendingProps=t,n.type=e.type,n.flags=0,n.nextEffect=null,n.firstEffect=null,n.lastEffect=null),n.childLanes=e.childLanes,n.lanes=e.lanes,n.child=e.child,n.memoizedProps=e.memoizedProps,n.memoizedState=e.memoizedState,n.updateQueue=e.updateQueue,t=e.dependencies,n.dependencies=null===t?null:{lanes:t.lanes,firstContext:t.firstContext},n.sibling=e.sibling,n.index=e.index,n.ref=e.ref,n}function Ru(e,t,n,r,a,l){var i=2;if(r=e,"function"==typeof e)Yu(e)&&(i=1);else if("string"==typeof e)i=5;else e:switch(e){case w:return Fu(n.children,a,l,t);case _:i=8,a|=16;break;case S:i=8,a|=1;break;case x:return(e=Uu(12,n,t,8|a)).elementType=x,e.type=x,e.lanes=l,e;case C:return(e=Uu(13,n,t,a)).type=C,e.elementType=C,e.lanes=l,e;case I:return(e=Uu(19,n,t,a)).elementType=I,e.lanes=l,e;case P:return Vu(n,a,l,t);case U:return(e=Uu(24,n,t,a)).elementType=U,e.lanes=l,e;default:if("object"==typeof e&&null!==e)switch(e.$$typeof){case k:i=10;break e;case j:i=9;break e;case T:i=11;break e;case D:i=14;break e;case O:i=16,r=null;break e;case z:i=22;break e}throw Error(o(130,null==e?e:typeof e,""))}return(t=Uu(i,n,t,a)).elementType=e,t.type=r,t.lanes=l,t}function Fu(e,t,n,r){return(e=Uu(7,e,r,t)).lanes=n,e}function Vu(e,t,n,r){return(e=Uu(23,e,r,t)).elementType=P,e.lanes=n,e}function Bu(e,t,n){return(e=Uu(6,e,null,t)).lanes=n,e}function Wu(e,t,n){return(t=Uu(4,null!==e.children?e.children:[],e.key,t)).lanes=n,t.stateNode={containerInfo:e.containerInfo,pendingChildren:null,implementation:e.implementation},t}function Hu(e,t,n){this.tag=t,this.containerInfo=e,this.finishedWork=this.pingCache=this.current=this.pendingChildren=null,this.timeoutHandle=-1,this.pendingContext=this.context=null,this.hydrate=n,this.callbackNode=null,this.callbackPriority=0,this.eventTimes=Rt(0),this.expirationTimes=Rt(-1),this.entangledLanes=this.finishedLanes=this.mutableReadLanes=this.expiredLanes=this.pingedLanes=this.suspendedLanes=this.pendingLanes=0,this.entanglements=Rt(0),this.mutableSourceEagerHydrationData=null}function Ku(e,t,n){var r=3<arguments.length&&void 0!==arguments[3]?arguments[3]:null;return{$$typeof:N,key:null==r?null:""+r,children:e,containerInfo:t,implementation:n}}function Gu(e,t,n,r){var a=t.current,l=ou(),i=iu(a);e:if(n){t:{if($e(n=n._reactInternals)!==n||1!==n.tag)throw Error(o(170));var u=n;do{switch(u.tag){case 3:u=u.stateNode.context;break t;case 1:if(pa(u.type)){u=u.stateNode.__reactInternalMemoizedMergedChildContext;break t}}u=u.return}while(null!==u);throw Error(o(171))}if(1===n.tag){var s=n.type;if(pa(s)){n=ga(n,s,u);break e}}n=u}else n=ua;return null===t.context?t.context=n:t.pendingContext=n,(t=ol(l,i)).payload={element:e},null!==(r=void 0===r?null:r)&&(t.callback=r),il(a,t),uu(a,i,l),i}function $u(e){if(!(e=e.current).child)return null;switch(e.child.tag){case 5:default:return e.child.stateNode}}function qu(e,t){if(null!==(e=e.memoizedState)&&null!==e.dehydrated){var n=e.retryLane;e.retryLane=0!==n&&n<t?n:t}}function Zu(e,t){qu(e,t),(e=e.alternate)&&qu(e,t)}function Xu(e,t,n){var r=null!=n&&null!=n.hydrationOptions&&n.hydrationOptions.mutableSources||null;if(n=new Hu(e,t,null!=n&&!0===n.hydrate),t=Uu(3,null,null,2===t?7:1===t?3:0),n.current=t,t.stateNode=n,al(t),e[qr]=n.current,jr(8===e.nodeType?e.parentNode:e),r)for(e=0;e<r.length;e++){var a=(t=r[e])._getVersion;a=a(t._source),null==n.mutableSourceEagerHydrationData?n.mutableSourceEagerHydrationData=[t,a]:n.mutableSourceEagerHydrationData.push(t,a)}this._internalRoot=n}function Ju(e){return!(!e||1!==e.nodeType&&9!==e.nodeType&&11!==e.nodeType&&(8!==e.nodeType||" react-mount-point-unstable "!==e.nodeValue))}function es(e,t,n,r,a){var l=n._reactRootContainer;if(l){var o=l._internalRoot;if("function"==typeof a){var i=a;a=function(){var e=$u(o);i.call(e)}}Gu(t,o,e,a)}else{if(l=n._reactRootContainer=function(e,t){if(t||(t=!(!(t=e?9===e.nodeType?e.documentElement:e.firstChild:null)||1!==t.nodeType||!t.hasAttribute("data-reactroot"))),!t)for(var n;n=e.lastChild;)e.removeChild(n);return new Xu(e,0,t?{hydrate:!0}:void 0)}(n,r),o=l._internalRoot,"function"==typeof a){var u=a;a=function(){var e=$u(o);u.call(e)}}hu((function(){Gu(t,o,e,a)}))}return $u(o)}function ts(e,t){var n=2<arguments.length&&void 0!==arguments[2]?arguments[2]:null;if(!Ju(t))throw Error(o(200));return Ku(e,t,null,n)}Fi=function(e,t,n){var r=t.lanes;if(null!==e)if(e.memoizedProps!==t.pendingProps||ca.current)Oo=!0;else{if(0==(n&r)){switch(Oo=!1,t.tag){case 3:Vo(t),Vl();break;case 5:Il(t);break;case 1:pa(t.type)&&ma(t);break;case 4:Tl(t,t.stateNode.containerInfo);break;case 10:r=t.memoizedProps.value;var a=t.type._context;ia(Ga,a._currentValue),a._currentValue=r;break;case 13:if(null!==t.memoizedState)return 0!=(n&t.child.childLanes)?Go(e,t,n):(ia(Ol,1&Ol.current),null!==(t=Jo(e,t,n))?t.sibling:null);ia(Ol,1&Ol.current);break;case 19:if(r=0!=(n&t.childLanes),0!=(64&e.flags)){if(r)return Xo(e,t,n);t.flags|=64}if(null!==(a=t.memoizedState)&&(a.rendering=null,a.tail=null,a.lastEffect=null),ia(Ol,Ol.current),r)break;return null;case 23:case 24:return t.lanes=0,Uo(e,t,n)}return Jo(e,t,n)}Oo=0!=(16384&e.flags)}else Oo=!1;switch(t.lanes=0,t.tag){case 2:if(r=t.type,null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=da(t,sa.current),tl(t,n),a=no(null,t,r,e,a,n),t.flags|=1,"object"==typeof a&&null!==a&&"function"==typeof a.render&&void 0===a.$$typeof){if(t.tag=1,t.memoizedState=null,t.updateQueue=null,pa(r)){var l=!0;ma(t)}else l=!1;t.memoizedState=null!==a.state&&void 0!==a.state?a.state:null,al(t);var i=r.getDerivedStateFromProps;"function"==typeof i&&dl(t,r,i,e),a.updater=pl,t.stateNode=a,a._reactInternals=t,ml(t,r,e,n),t=Fo(null,t,r,!0,l,n)}else t.tag=0,zo(null,t,a,n),t=t.child;return t;case 16:a=t.elementType;e:{switch(null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=(l=a._init)(a._payload),t.type=a,l=t.tag=function(e){if("function"==typeof e)return Yu(e)?1:0;if(null!=e){if((e=e.$$typeof)===T)return 11;if(e===D)return 14}return 2}(a),e=Ka(a,e),l){case 0:t=Qo(null,t,a,e,n);break e;case 1:t=Ro(null,t,a,e,n);break e;case 11:t=Ao(null,t,a,e,n);break e;case 14:t=_o(null,t,a,Ka(a.type,e),r,n);break e}throw Error(o(306,a,""))}return t;case 0:return r=t.type,a=t.pendingProps,Qo(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 1:return r=t.type,a=t.pendingProps,Ro(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 3:if(Vo(t),r=t.updateQueue,null===e||null===r)throw Error(o(282));if(r=t.pendingProps,a=null!==(a=t.memoizedState)?a.element:null,ll(e,t),sl(t,r,null,n),(r=t.memoizedState.element)===a)Vl(),t=Jo(e,t,n);else{if((l=(a=t.stateNode).hydrate)&&(_l=Br(t.stateNode.containerInfo.firstChild),Al=t,l=Pl=!0),l){if(null!=(e=a.mutableSourceEagerHydrationData))for(a=0;a<e.length;a+=2)(l=e[a])._workInProgressVersionPrimary=e[a+1],Bl.push(l);for(n=Nl(t,null,r,n),t.child=n;n;)n.flags=-3&n.flags|1024,n=n.sibling}else zo(e,t,r,n),Vl();t=t.child}return t;case 5:return Il(t),null===e&&Ql(t),r=t.type,a=t.pendingProps,l=null!==e?e.memoizedProps:null,i=a.children,Qr(r,a)?i=null:null!==l&&Qr(r,l)&&(t.flags|=16),Yo(e,t),zo(e,t,i,n),t.child;case 6:return null===e&&Ql(t),null;case 13:return Go(e,t,n);case 4:return Tl(t,t.stateNode.containerInfo),r=t.pendingProps,null===e?t.child=Ll(t,null,r,n):zo(e,t,r,n),t.child;case 11:return r=t.type,a=t.pendingProps,Ao(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 7:return zo(e,t,t.pendingProps,n),t.child;case 8:case 12:return zo(e,t,t.pendingProps.children,n),t.child;case 10:e:{r=t.type._context,a=t.pendingProps,i=t.memoizedProps,l=a.value;var u=t.type._context;if(ia(Ga,u._currentValue),u._currentValue=l,null!==i)if(u=i.value,0==(l=or(u,l)?0:0|("function"==typeof r._calculateChangedBits?r._calculateChangedBits(u,l):1073741823))){if(i.children===a.children&&!ca.current){t=Jo(e,t,n);break e}}else for(null!==(u=t.child)&&(u.return=t);null!==u;){var s=u.dependencies;if(null!==s){i=u.child;for(var c=s.firstContext;null!==c;){if(c.context===r&&0!=(c.observedBits&l)){1===u.tag&&((c=ol(-1,n&-n)).tag=2,il(u,c)),u.lanes|=n,null!==(c=u.alternate)&&(c.lanes|=n),el(u.return,n),s.lanes|=n;break}c=c.next}}else i=10===u.tag&&u.type===t.type?null:u.child;if(null!==i)i.return=u;else for(i=u;null!==i;){if(i===t){i=null;break}if(null!==(u=i.sibling)){u.return=i.return,i=u;break}i=i.return}u=i}zo(e,t,a.children,n),t=t.child}return t;case 9:return a=t.type,r=(l=t.pendingProps).children,tl(t,n),r=r(a=nl(a,l.unstable_observedBits)),t.flags|=1,zo(e,t,r,n),t.child;case 14:return l=Ka(a=t.type,t.pendingProps),_o(e,t,a,l=Ka(a.type,l),r,n);case 15:return Po(e,t,t.type,t.pendingProps,r,n);case 17:return r=t.type,a=t.pendingProps,a=t.elementType===r?a:Ka(r,a),null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),t.tag=1,pa(r)?(e=!0,ma(t)):e=!1,tl(t,n),hl(t,r,a),ml(t,r,a,n),Fo(null,t,r,!0,e,n);case 19:return Xo(e,t,n);case 23:case 24:return Uo(e,t,n)}throw Error(o(156,t.tag))},Xu.prototype.render=function(e){Gu(e,this._internalRoot,null,null)},Xu.prototype.unmount=function(){var e=this._internalRoot,t=e.containerInfo;Gu(null,e,null,(function(){t[qr]=null}))},et=function(e){13===e.tag&&(uu(e,4,ou()),Zu(e,4))},tt=function(e){13===e.tag&&(uu(e,67108864,ou()),Zu(e,67108864))},nt=function(e){if(13===e.tag){var t=ou(),n=iu(e);uu(e,n,t),Zu(e,n)}},rt=function(e,t){return t()},xe=function(e,t,n){switch(t){case"input":if(ne(e,n),t=n.name,"radio"===n.type&&null!=t){for(n=e;n.parentNode;)n=n.parentNode;for(n=n.querySelectorAll("input[name="+JSON.stringify(""+t)+'][type="radio"]'),t=0;t<n.length;t++){var r=n[t];if(r!==e&&r.form===e.form){var a=ta(r);if(!a)throw Error(o(90));Z(r),ne(r,a)}}}break;case"textarea":se(e,n);break;case"select":null!=(t=n.value)&&oe(e,!!n.multiple,t,!1)}},De=yu,Oe=function(e,t,n,r,a){var l=xi;xi|=4;try{return Fa(98,e.bind(null,t,n,r,a))}finally{0===(xi=l)&&(Ri(),Ba())}},ze=function(){0==(49&xi)&&(function(){if(null!==Xi){var e=Xi;Xi=null,e.forEach((function(e){e.expiredLanes|=24&e.pendingLanes,cu(e,Ya())}))}Ba()}(),Tu())},Ae=function(e,t){var n=xi;xi|=2;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}};var ns={Events:[Jr,ea,ta,Ce,Ie,Tu,{current:!1}]},rs={findFiberByHostInstance:Xr,bundleType:0,version:"17.0.2",rendererPackageName:"react-dom"},as={bundleType:rs.bundleType,version:rs.version,rendererPackageName:rs.rendererPackageName,rendererConfig:rs.rendererConfig,overrideHookState:null,overrideHookStateDeletePath:null,overrideHookStateRenamePath:null,overrideProps:null,overridePropsDeletePath:null,overridePropsRenamePath:null,setSuspenseHandler:null,scheduleUpdate:null,currentDispatcherRef:E.ReactCurrentDispatcher,findHostInstanceByFiber:function(e){return null===(e=Xe(e))?null:e.stateNode},findFiberByHostInstance:rs.findFiberByHostInstance||function(){return null},findHostInstancesForRefresh:null,scheduleRefresh:null,scheduleRoot:null,setRefreshHandler:null,getCurrentFiber:null};if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__){var ls=__REACT_DEVTOOLS_GLOBAL_HOOK__;if(!ls.isDisabled&&ls.supportsFiber)try{ba=ls.inject(as),Ma=ls}catch(he){}}t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=ns,t.createPortal=ts,t.findDOMNode=function(e){if(null==e)return null;if(1===e.nodeType)return e;var t=e._reactInternals;if(void 0===t){if("function"==typeof e.render)throw Error(o(188));throw Error(o(268,Object.keys(e)))}return null===(e=Xe(t))?null:e.stateNode},t.flushSync=function(e,t){var n=xi;if(0!=(48&n))return e(t);xi|=1;try{if(e)return Fa(99,e.bind(null,t))}finally{xi=n,Ba()}},t.hydrate=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!0,n)},t.render=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!1,n)},t.unmountComponentAtNode=function(e){if(!Ju(e))throw Error(o(40));return!!e._reactRootContainer&&(hu((function(){es(null,null,e,!1,(function(){e._reactRootContainer=null,e[qr]=null}))})),!0)},t.unstable_batchedUpdates=yu,t.unstable_createPortal=function(e,t){return ts(e,t,2<arguments.length&&void 0!==arguments[2]?arguments[2]:null)},t.unstable_renderSubtreeIntoContainer=function(e,t,n,r){if(!Ju(n))throw Error(o(200));if(null==e||void 0===e._reactInternals)throw Error(o(38));return es(e,t,n,!1,r)},t.version="17.0.2"},935:(e,t,n)=>{"use strict";!function e(){if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__&&"function"==typeof __REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE)try{__REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE(e)}catch(e){console.error(e)}}(),e.exports=n(448)},357:(e,t,n)=>{"use strict";function r(){return(r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e}).apply(this,arguments)}function a(e,t){if(null==e)return{};var n,r,a={},l=Object.keys(e);for(r=0;r<l.length;r++)n=l[r],t.indexOf(n)>=0||(a[n]=e[n]);return a}function l(e,t){return(l=Object.setPrototypeOf||function(e,t){return e.__proto__=t,e})(e,t)}function o(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,l(e,t)}function i(e,t){return e.replace(new RegExp("(^|\\s)"+t+"(?:\\s|$)","g"),"$1").replace(/\s+/g," ").replace(/^\s*|\s*$/g,"")}n.r(t),n.d(t,{CSSTransition:()=>N,ReplaceTransition:()=>I,SwitchTransition:()=>Q,Transition:()=>M,TransitionGroup:()=>T,config:()=>c});var u=n(294),s=n(935);const c={disabled:!1},f=u.createContext(null);var d=function(e){return e.scrollTop},p="unmounted",y="exited",h="entering",g="entered",m="exiting",v=function(e){function t(t,n){var r;r=e.call(this,t,n)||this;var a,l=n&&!n.isMounting?t.enter:t.appear;return r.appearStatus=null,t.in?l?(a=y,r.appearStatus=h):a=g:a=t.unmountOnExit||t.mountOnEnter?p:y,r.state={status:a},r.nextCallback=null,r}o(t,e),t.getDerivedStateFromProps=function(e,t){return e.in&&t.status===p?{status:y}:null};var n=t.prototype;return n.componentDidMount=function(){this.updateStatus(!0,this.appearStatus)},n.componentDidUpdate=function(e){var t=null;if(e!==this.props){var n=this.state.status;this.props.in?n!==h&&n!==g&&(t=h):n!==h&&n!==g||(t=m)}this.updateStatus(!1,t)},n.componentWillUnmount=function(){this.cancelNextCallback()},n.getTimeouts=function(){var e,t,n,r=this.props.timeout;return e=t=n=r,null!=r&&"number"!=typeof r&&(e=r.exit,t=r.enter,n=void 0!==r.appear?r.appear:t),{exit:e,enter:t,appear:n}},n.updateStatus=function(e,t){if(void 0===e&&(e=!1),null!==t)if(this.cancelNextCallback(),t===h){if(this.props.unmountOnExit||this.props.mountOnEnter){var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this);n&&d(n)}this.performEnter(e)}else this.performExit();else this.props.unmountOnExit&&this.state.status===y&&this.setState({status:p})},n.performEnter=function(e){var t=this,n=this.props.enter,r=this.context?this.context.isMounting:e,a=this.props.nodeRef?[r]:[s.findDOMNode(this),r],l=a[0],o=a[1],i=this.getTimeouts(),u=r?i.appear:i.enter;!e&&!n||c.disabled?this.safeSetState({status:g},(function(){t.props.onEntered(l)})):(this.props.onEnter(l,o),this.safeSetState({status:h},(function(){t.props.onEntering(l,o),t.onTransitionEnd(u,(function(){t.safeSetState({status:g},(function(){t.props.onEntered(l,o)}))}))})))},n.performExit=function(){var e=this,t=this.props.exit,n=this.getTimeouts(),r=this.props.nodeRef?void 0:s.findDOMNode(this);t&&!c.disabled?(this.props.onExit(r),this.safeSetState({status:m},(function(){e.props.onExiting(r),e.onTransitionEnd(n.exit,(function(){e.safeSetState({status:y},(function(){e.props.onExited(r)}))}))}))):this.safeSetState({status:y},(function(){e.props.onExited(r)}))},n.cancelNextCallback=function(){null!==this.nextCallback&&(this.nextCallback.cancel(),this.nextCallback=null)},n.safeSetState=function(e,t){t=this.setNextCallback(t),this.setState(e,t)},n.setNextCallback=function(e){var t=this,n=!0;return this.nextCallback=function(r){n&&(n=!1,t.nextCallback=null,e(r))},this.nextCallback.cancel=function(){n=!1},this.nextCallback},n.onTransitionEnd=function(e,t){this.setNextCallback(t);var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this),r=null==e&&!this.props.addEndListener;if(n&&!r){if(this.props.addEndListener){var a=this.props.nodeRef?[this.nextCallback]:[n,this.nextCallback],l=a[0],o=a[1];this.props.addEndListener(l,o)}null!=e&&setTimeout(this.nextCallback,e)}else setTimeout(this.nextCallback,0)},n.render=function(){var e=this.state.status;if(e===p)return null;var t=this.props,n=t.children,r=(t.in,t.mountOnEnter,t.unmountOnExit,t.appear,t.enter,t.exit,t.timeout,t.addEndListener,t.onEnter,t.onEntering,t.onEntered,t.onExit,t.onExiting,t.onExited,t.nodeRef,a(t,["children","in","mountOnEnter","unmountOnExit","appear","enter","exit","timeout","addEndListener","onEnter","onEntering","onEntered","onExit","onExiting","onExited","nodeRef"]));return u.createElement(f.Provider,{value:null},"function"==typeof n?n(e,r):u.cloneElement(u.Children.only(n),r))},t}(u.Component);function b(){}v.contextType=f,v.propTypes={},v.defaultProps={in:!1,mountOnEnter:!1,unmountOnExit:!1,appear:!1,enter:!0,exit:!0,onEnter:b,onEntering:b,onEntered:b,onExit:b,onExiting:b,onExited:b},v.UNMOUNTED=p,v.EXITED=y,v.ENTERING=h,v.ENTERED=g,v.EXITING=m;const M=v;var E=function(e,t){return e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.remove(r):"string"==typeof n.className?n.className=i(n.className,r):n.setAttribute("class",i(n.className&&n.className.baseVal||"",r)));var n,r}))},L=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).appliedClasses={appear:{},enter:{},exit:{}},t.onEnter=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1];t.removeClasses(a,"exit"),t.addClass(a,l?"appear":"enter","base"),t.props.onEnter&&t.props.onEnter(e,n)},t.onEntering=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.addClass(a,l,"active"),t.props.onEntering&&t.props.onEntering(e,n)},t.onEntered=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.removeClasses(a,l),t.addClass(a,l,"done"),t.props.onEntered&&t.props.onEntered(e,n)},t.onExit=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"appear"),t.removeClasses(n,"enter"),t.addClass(n,"exit","base"),t.props.onExit&&t.props.onExit(e)},t.onExiting=function(e){var n=t.resolveArguments(e)[0];t.addClass(n,"exit","active"),t.props.onExiting&&t.props.onExiting(e)},t.onExited=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"exit"),t.addClass(n,"exit","done"),t.props.onExited&&t.props.onExited(e)},t.resolveArguments=function(e,n){return t.props.nodeRef?[t.props.nodeRef.current,e]:[e,n]},t.getClassNames=function(e){var n=t.props.classNames,r="string"==typeof n,a=r?(r&&n?n+"-":"")+e:n[e];return{baseClassName:a,activeClassName:r?a+"-active":n[e+"Active"],doneClassName:r?a+"-done":n[e+"Done"]}},t}o(t,e);var n=t.prototype;return n.addClass=function(e,t,n){var r=this.getClassNames(t)[n+"ClassName"],a=this.getClassNames("enter").doneClassName;"appear"===t&&"done"===n&&a&&(r+=" "+a),"active"===n&&e&&d(e),r&&(this.appliedClasses[t][n]=r,function(e,t){e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.add(r):function(e,t){return e.classList?!!t&&e.classList.contains(t):-1!==(" "+(e.className.baseVal||e.className)+" ").indexOf(" "+t+" ")}(n,r)||("string"==typeof n.className?n.className=n.className+" "+r:n.setAttribute("class",(n.className&&n.className.baseVal||"")+" "+r)));var n,r}))}(e,r))},n.removeClasses=function(e,t){var n=this.appliedClasses[t],r=n.base,a=n.active,l=n.done;this.appliedClasses[t]={},r&&E(e,r),a&&E(e,a),l&&E(e,l)},n.render=function(){var e=this.props,t=(e.classNames,a(e,["classNames"]));return u.createElement(M,r({},t,{onEnter:this.onEnter,onEntered:this.onEntered,onEntering:this.onEntering,onExit:this.onExit,onExiting:this.onExiting,onExited:this.onExited}))},t}(u.Component);L.defaultProps={classNames:""},L.propTypes={};const N=L;function w(e,t){var n=Object.create(null);return e&&u.Children.map(e,(function(e){return e})).forEach((function(e){n[e.key]=function(e){return t&&(0,u.isValidElement)(e)?t(e):e}(e)})),n}function S(e,t,n){return null!=n[t]?n[t]:e.props[t]}function x(e,t,n){var r=w(e.children),a=function(e,t){function n(n){return n in t?t[n]:e[n]}e=e||{},t=t||{};var r,a=Object.create(null),l=[];for(var o in e)o in t?l.length&&(a[o]=l,l=[]):l.push(o);var i={};for(var u in t){if(a[u])for(r=0;r<a[u].length;r++){var s=a[u][r];i[a[u][r]]=n(s)}i[u]=n(u)}for(r=0;r<l.length;r++)i[l[r]]=n(l[r]);return i}(t,r);return Object.keys(a).forEach((function(l){var o=a[l];if((0,u.isValidElement)(o)){var i=l in t,s=l in r,c=t[l],f=(0,u.isValidElement)(c)&&!c.props.in;!s||i&&!f?s||!i||f?s&&i&&(0,u.isValidElement)(c)&&(a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:c.props.in,exit:S(o,"exit",e),enter:S(o,"enter",e)})):a[l]=(0,u.cloneElement)(o,{in:!1}):a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:!0,exit:S(o,"exit",e),enter:S(o,"enter",e)})}})),a}var k=Object.values||function(e){return Object.keys(e).map((function(t){return e[t]}))},j=function(e){function t(t,n){var r,a=(r=e.call(this,t,n)||this).handleExited.bind(function(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}(r));return r.state={contextValue:{isMounting:!0},handleExited:a,firstRender:!0},r}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.mounted=!0,this.setState({contextValue:{isMounting:!1}})},n.componentWillUnmount=function(){this.mounted=!1},t.getDerivedStateFromProps=function(e,t){var n,r,a=t.children,l=t.handleExited;return{children:t.firstRender?(n=e,r=l,w(n.children,(function(e){return(0,u.cloneElement)(e,{onExited:r.bind(null,e),in:!0,appear:S(e,"appear",n),enter:S(e,"enter",n),exit:S(e,"exit",n)})}))):x(e,a,l),firstRender:!1}},n.handleExited=function(e,t){var n=w(this.props.children);e.key in n||(e.props.onExited&&e.props.onExited(t),this.mounted&&this.setState((function(t){var n=r({},t.children);return delete n[e.key],{children:n}})))},n.render=function(){var e=this.props,t=e.component,n=e.childFactory,r=a(e,["component","childFactory"]),l=this.state.contextValue,o=k(this.state.children).map(n);return delete r.appear,delete r.enter,delete r.exit,null===t?u.createElement(f.Provider,{value:l},o):u.createElement(f.Provider,{value:l},u.createElement(t,r,o))},t}(u.Component);j.propTypes={},j.defaultProps={component:"div",childFactory:function(e){return e}};const T=j;var C=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).handleEnter=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEnter",0,n)},t.handleEntering=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntering",0,n)},t.handleEntered=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntered",0,n)},t.handleExit=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExit",1,n)},t.handleExiting=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExiting",1,n)},t.handleExited=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExited",1,n)},t}o(t,e);var n=t.prototype;return n.handleLifecycle=function(e,t,n){var r,a=this.props.children,l=u.Children.toArray(a)[t];if(l.props[e]&&(r=l.props)[e].apply(r,n),this.props[e]){var o=l.props.nodeRef?void 0:s.findDOMNode(this);this.props[e](o)}},n.render=function(){var e=this.props,t=e.children,n=e.in,r=a(e,["children","in"]),l=u.Children.toArray(t),o=l[0],i=l[1];return delete r.onEnter,delete r.onEntering,delete r.onEntered,delete r.onExit,delete r.onExiting,delete r.onExited,u.createElement(T,r,n?u.cloneElement(o,{key:"first",onEnter:this.handleEnter,onEntering:this.handleEntering,onEntered:this.handleEntered}):u.cloneElement(i,{key:"second",onEnter:this.handleExit,onEntering:this.handleExiting,onEntered:this.handleExited}))},t}(u.Component);C.propTypes={};const I=C;var D,O,z="out-in",A="in-out",_=function(e,t,n){return function(){var r;e.props[t]&&(r=e.props)[t].apply(r,arguments),n()}},P=((D={})["out-in"]=function(e){var t=e.current,n=e.changeState;return u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){n(h,null)}))})},D[A]=function(e){var t=e.current,n=e.changeState,r=e.children;return[t,u.cloneElement(r,{in:!0,onEntered:_(r,"onEntered",(function(){n(h)}))})]},D),U=((O={})["out-in"]=function(e){var t=e.children,n=e.changeState;return u.cloneElement(t,{in:!0,onEntered:_(t,"onEntered",(function(){n(g,u.cloneElement(t,{in:!0}))}))})},O[A]=function(e){var t=e.current,n=e.children,r=e.changeState;return[u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){r(g,u.cloneElement(n,{in:!0}))}))}),u.cloneElement(n,{in:!0})]},O),Y=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).state={status:g,current:null},t.appeared=!1,t.changeState=function(e,n){void 0===n&&(n=t.state.current),t.setState({status:e,current:n})},t}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.appeared=!0},t.getDerivedStateFromProps=function(e,t){return null==e.children?{current:null}:t.status===h&&e.mode===A?{status:h}:!t.current||((n=t.current)===(r=e.children)||u.isValidElement(n)&&u.isValidElement(r)&&null!=n.key&&n.key===r.key)?{current:u.cloneElement(e.children,{in:!0})}:{status:m};var n,r},n.render=function(){var e,t=this.props,n=t.children,r=t.mode,a=this.state,l=a.status,o=a.current,i={children:n,current:o,changeState:this.changeState,status:l};switch(l){case h:e=U[r](i);break;case m:e=P[r](i);break;case g:e=o}return u.createElement(f.Provider,{value:{isMounting:!this.appeared}},e)},t}(u.Component);Y.propTypes={},Y.defaultProps={mode:z};const Q=Y},408:(e,t,n)=>{"use strict";var r=n(418),a=60103,l=60106;t.Fragment=60107,t.StrictMode=60108,t.Profiler=60114;var o=60109,i=60110,u=60112;t.Suspense=60113;var s=60115,c=60116;if("function"==typeof Symbol&&Symbol.for){var f=Symbol.for;a=f("react.element"),l=f("react.portal"),t.Fragment=f("react.fragment"),t.StrictMode=f("react.strict_mode"),t.Profiler=f("react.profiler"),o=f("react.provider"),i=f("react.context"),u=f("react.forward_ref"),t.Suspense=f("react.suspense"),s=f("react.memo"),c=f("react.lazy")}var d="function"==typeof Symbol&&Symbol.iterator;function p(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}var y={isMounted:function(){return!1},enqueueForceUpdate:function(){},enqueueReplaceState:function(){},enqueueSetState:function(){}},h={};function g(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}function m(){}function v(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}g.prototype.isReactComponent={},g.prototype.setState=function(e,t){if("object"!=typeof e&&"function"!=typeof e&&null!=e)throw Error(p(85));this.updater.enqueueSetState(this,e,t,"setState")},g.prototype.forceUpdate=function(e){this.updater.enqueueForceUpdate(this,e,"forceUpdate")},m.prototype=g.prototype;var b=v.prototype=new m;b.constructor=v,r(b,g.prototype),b.isPureReactComponent=!0;var M={current:null},E=Object.prototype.hasOwnProperty,L={key:!0,ref:!0,__self:!0,__source:!0};function N(e,t,n){var r,l={},o=null,i=null;if(null!=t)for(r in void 0!==t.ref&&(i=t.ref),void 0!==t.key&&(o=""+t.key),t)E.call(t,r)&&!L.hasOwnProperty(r)&&(l[r]=t[r]);var u=arguments.length-2;if(1===u)l.children=n;else if(1<u){for(var s=Array(u),c=0;c<u;c++)s[c]=arguments[c+2];l.children=s}if(e&&e.defaultProps)for(r in u=e.defaultProps)void 0===l[r]&&(l[r]=u[r]);return{$$typeof:a,type:e,key:o,ref:i,props:l,_owner:M.current}}function w(e){return"object"==typeof e&&null!==e&&e.$$typeof===a}var S=/\/+/g;function x(e,t){return"object"==typeof e&&null!==e&&null!=e.key?function(e){var t={"=":"=0",":":"=2"};return"$"+e.replace(/[=:]/g,(function(e){return t[e]}))}(""+e.key):t.toString(36)}function k(e,t,n,r,o){var i=typeof e;"undefined"!==i&&"boolean"!==i||(e=null);var u=!1;if(null===e)u=!0;else switch(i){case"string":case"number":u=!0;break;case"object":switch(e.$$typeof){case a:case l:u=!0}}if(u)return o=o(u=e),e=""===r?"."+x(u,0):r,Array.isArray(o)?(n="",null!=e&&(n=e.replace(S,"$&/")+"/"),k(o,t,n,"",(function(e){return e}))):null!=o&&(w(o)&&(o=function(e,t){return{$$typeof:a,type:e.type,key:t,ref:e.ref,props:e.props,_owner:e._owner}}(o,n+(!o.key||u&&u.key===o.key?"":(""+o.key).replace(S,"$&/")+"/")+e)),t.push(o)),1;if(u=0,r=""===r?".":r+":",Array.isArray(e))for(var s=0;s<e.length;s++){var c=r+x(i=e[s],s);u+=k(i,t,n,c,o)}else if("function"==typeof(c=function(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=d&&e[d]||e["@iterator"])?e:null}(e)))for(e=c.call(e),s=0;!(i=e.next()).done;)u+=k(i=i.value,t,n,c=r+x(i,s++),o);else if("object"===i)throw t=""+e,Error(p(31,"[object Object]"===t?"object with keys {"+Object.keys(e).join(", ")+"}":t));return u}function j(e,t,n){if(null==e)return e;var r=[],a=0;return k(e,r,"","",(function(e){return t.call(n,e,a++)})),r}function T(e){if(-1===e._status){var t=e._result;t=t(),e._status=0,e._result=t,t.then((function(t){0===e._status&&(t=t.default,e._status=1,e._result=t)}),(function(t){0===e._status&&(e._status=2,e._result=t)}))}if(1===e._status)return e._result;throw e._result}var C={current:null};function I(){var e=C.current;if(null===e)throw Error(p(321));return e}var D={ReactCurrentDispatcher:C,ReactCurrentBatchConfig:{transition:0},ReactCurrentOwner:M,IsSomeRendererActing:{current:!1},assign:r};t.Children={map:j,forEach:function(e,t,n){j(e,(function(){t.apply(this,arguments)}),n)},count:function(e){var t=0;return j(e,(function(){t++})),t},toArray:function(e){return j(e,(function(e){return e}))||[]},only:function(e){if(!w(e))throw Error(p(143));return e}},t.Component=g,t.PureComponent=v,t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=D,t.cloneElement=function(e,t,n){if(null==e)throw Error(p(267,e));var l=r({},e.props),o=e.key,i=e.ref,u=e._owner;if(null!=t){if(void 0!==t.ref&&(i=t.ref,u=M.current),void 0!==t.key&&(o=""+t.key),e.type&&e.type.defaultProps)var s=e.type.defaultProps;for(c in t)E.call(t,c)&&!L.hasOwnProperty(c)&&(l[c]=void 0===t[c]&&void 0!==s?s[c]:t[c])}var c=arguments.length-2;if(1===c)l.children=n;else if(1<c){s=Array(c);for(var f=0;f<c;f++)s[f]=arguments[f+2];l.children=s}return{$$typeof:a,type:e.type,key:o,ref:i,props:l,_owner:u}},t.createContext=function(e,t){return void 0===t&&(t=null),(e={$$typeof:i,_calculateChangedBits:t,_currentValue:e,_currentValue2:e,_threadCount:0,Provider:null,Consumer:null}).Provider={$$typeof:o,_context:e},e.Consumer=e},t.createElement=N,t.createFactory=function(e){var t=N.bind(null,e);return t.type=e,t},t.createRef=function(){return{current:null}},t.forwardRef=function(e){return{$$typeof:u,render:e}},t.isValidElement=w,t.lazy=function(e){return{$$typeof:c,_payload:{_status:-1,_result:e},_init:T}},t.memo=function(e,t){return{$$typeof:s,type:e,compare:void 0===t?null:t}},t.useCallback=function(e,t){return I().useCallback(e,t)},t.useContext=function(e,t){return I().useContext(e,t)},t.useDebugValue=function(){},t.useEffect=function(e,t){return I().useEffect(e,t)},t.useImperativeHandle=function(e,t,n){return I().useImperativeHandle(e,t,n)},t.useLayoutEffect=function(e,t){return I().useLayoutEffect(e,t)},t.useMemo=function(e,t){return I().useMemo(e,t)},t.useReducer=function(e,t,n){return I().useReducer(e,t,n)},t.useRef=function(e){return I().useRef(e)},t.useState=function(e){return I().useState(e)},t.version="17.0.2"},294:(e,t,n)=>{"use strict";e.exports=n(408)},53:(e,t)=>{"use strict";var n,r,a,l;if("object"==typeof performance&&"function"==typeof performance.now){var o=performance;t.unstable_now=function(){return o.now()}}else{var i=Date,u=i.now();t.unstable_now=function(){return i.now()-u}}if("undefined"==typeof window||"function"!=typeof MessageChannel){var s=null,c=null,f=function(){if(null!==s)try{var e=t.unstable_now();s(!0,e),s=null}catch(e){throw setTimeout(f,0),e}};n=function(e){null!==s?setTimeout(n,0,e):(s=e,setTimeout(f,0))},r=function(e,t){c=setTimeout(e,t)},a=function(){clearTimeout(c)},t.unstable_shouldYield=function(){return!1},l=t.unstable_forceFrameRate=function(){}}else{var d=window.setTimeout,p=window.clearTimeout;if("undefined"!=typeof console){var y=window.cancelAnimationFrame;"function"!=typeof window.requestAnimationFrame&&console.error("This browser doesn't support requestAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills"),"function"!=typeof y&&console.error("This browser doesn't support cancelAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills")}var h=!1,g=null,m=-1,v=5,b=0;t.unstable_shouldYield=function(){return t.unstable_now()>=b},l=function(){},t.unstable_forceFrameRate=function(e){0>e||125<e?console.error("forceFrameRate takes a positive int between 0 and 125, forcing frame rates higher than 125 fps is not supported"):v=0<e?Math.floor(1e3/e):5};var M=new MessageChannel,E=M.port2;M.port1.onmessage=function(){if(null!==g){var e=t.unstable_now();b=e+v;try{g(!0,e)?E.postMessage(null):(h=!1,g=null)}catch(e){throw E.postMessage(null),e}}else h=!1},n=function(e){g=e,h||(h=!0,E.postMessage(null))},r=function(e,n){m=d((function(){e(t.unstable_now())}),n)},a=function(){p(m),m=-1}}function L(e,t){var n=e.length;e.push(t);e:for(;;){var r=n-1>>>1,a=e[r];if(!(void 0!==a&&0<S(a,t)))break e;e[r]=t,e[n]=a,n=r}}function N(e){return void 0===(e=e[0])?null:e}function w(e){var t=e[0];if(void 0!==t){var n=e.pop();if(n!==t){e[0]=n;e:for(var r=0,a=e.length;r<a;){var l=2*(r+1)-1,o=e[l],i=l+1,u=e[i];if(void 0!==o&&0>S(o,n))void 0!==u&&0>S(u,o)?(e[r]=u,e[i]=n,r=i):(e[r]=o,e[l]=n,r=l);else{if(!(void 0!==u&&0>S(u,n)))break e;e[r]=u,e[i]=n,r=i}}}return t}return null}function S(e,t){var n=e.sortIndex-t.sortIndex;return 0!==n?n:e.id-t.id}var x=[],k=[],j=1,T=null,C=3,I=!1,D=!1,O=!1;function z(e){for(var t=N(k);null!==t;){if(null===t.callback)w(k);else{if(!(t.startTime<=e))break;w(k),t.sortIndex=t.expirationTime,L(x,t)}t=N(k)}}function A(e){if(O=!1,z(e),!D)if(null!==N(x))D=!0,n(_);else{var t=N(k);null!==t&&r(A,t.startTime-e)}}function _(e,n){D=!1,O&&(O=!1,a()),I=!0;var l=C;try{for(z(n),T=N(x);null!==T&&(!(T.expirationTime>n)||e&&!t.unstable_shouldYield());){var o=T.callback;if("function"==typeof o){T.callback=null,C=T.priorityLevel;var i=o(T.expirationTime<=n);n=t.unstable_now(),"function"==typeof i?T.callback=i:T===N(x)&&w(x),z(n)}else w(x);T=N(x)}if(null!==T)var u=!0;else{var s=N(k);null!==s&&r(A,s.startTime-n),u=!1}return u}finally{T=null,C=l,I=!1}}var P=l;t.unstable_IdlePriority=5,t.unstable_ImmediatePriority=1,t.unstable_LowPriority=4,t.unstable_NormalPriority=3,t.unstable_Profiling=null,t.unstable_UserBlockingPriority=2,t.unstable_cancelCallback=function(e){e.callback=null},t.unstable_continueExecution=function(){D||I||(D=!0,n(_))},t.unstable_getCurrentPriorityLevel=function(){return C},t.unstable_getFirstCallbackNode=function(){return N(x)},t.unstable_next=function(e){switch(C){case 1:case 2:case 3:var t=3;break;default:t=C}var n=C;C=t;try{return e()}finally{C=n}},t.unstable_pauseExecution=function(){},t.unstable_requestPaint=P,t.unstable_runWithPriority=function(e,t){switch(e){case 1:case 2:case 3:case 4:case 5:break;default:e=3}var n=C;C=e;try{return t()}finally{C=n}},t.unstable_scheduleCallback=function(e,l,o){var i=t.unstable_now();switch(o="object"==typeof o&&null!==o&&"number"==typeof(o=o.delay)&&0<o?i+o:i,e){case 1:var u=-1;break;case 2:u=250;break;case 5:u=1073741823;break;case 4:u=1e4;break;default:u=5e3}return e={id:j++,callback:l,priorityLevel:e,startTime:o,expirationTime:u=o+u,sortIndex:-1},o>i?(e.sortIndex=o,L(k,e),null===N(x)&&e===N(k)&&(O?a():O=!0,r(A,o-i))):(e.sortIndex=u,L(x,e),D||I||(D=!0,n(_))),e},t.unstable_wrapCallback=function(e){var t=C;return function(){var n=C;C=t;try{return e.apply(this,arguments)}finally{C=n}}}},840:(e,t,n)=>{"use strict";e.exports=n(53)},188:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(151);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},413:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(148);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},810:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(908);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},454:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(174);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},379:(e,t,n)=>{"use strict";var r,a=function(){var e={};return function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}e[t]=n}return e[t]}}(),l=[];function o(e){for(var t=-1,n=0;n<l.length;n++)if(l[n].identifier===e){t=n;break}return t}function i(e,t){for(var n={},r=[],a=0;a<e.length;a++){var i=e[a],u=t.base?i[0]+t.base:i[0],s=n[u]||0,c="".concat(u," ").concat(s);n[u]=s+1;var f=o(c),d={css:i[1],media:i[2],sourceMap:i[3]};-1!==f?(l[f].references++,l[f].updater(d)):l.push({identifier:c,updater:h(d,t),references:1}),r.push(c)}return r}function u(e){var t=document.createElement("style"),r=e.attributes||{};if(void 0===r.nonce){var l=n.nc;l&&(r.nonce=l)}if(Object.keys(r).forEach((function(e){t.setAttribute(e,r[e])})),"function"==typeof e.insert)e.insert(t);else{var o=a(e.insert||"head");if(!o)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");o.appendChild(t)}return t}var s,c=(s=[],function(e,t){return s[e]=t,s.filter(Boolean).join("\n")});function f(e,t,n,r){var a=n?"":r.media?"@media ".concat(r.media," {").concat(r.css,"}"):r.css;if(e.styleSheet)e.styleSheet.cssText=c(t,a);else{var l=document.createTextNode(a),o=e.childNodes;o[t]&&e.removeChild(o[t]),o.length?e.insertBefore(l,o[t]):e.appendChild(l)}}function d(e,t,n){var r=n.css,a=n.media,l=n.sourceMap;if(a?e.setAttribute("media",a):e.removeAttribute("media"),l&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(l))))," */")),e.styleSheet)e.styleSheet.cssText=r;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(r))}}var p=null,y=0;function h(e,t){var n,r,a;if(t.singleton){var l=y++;n=p||(p=u(t)),r=f.bind(null,n,l,!1),a=f.bind(null,n,l,!0)}else n=u(t),r=d.bind(null,n,t),a=function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(n)};return r(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap)return;r(e=t)}else a()}}e.exports=function(e,t){(t=t||{}).singleton||"boolean"==typeof t.singleton||(t.singleton=(void 0===r&&(r=Boolean(window&&document&&document.all&&!window.atob)),r));var n=i(e=e||[],t);return function(e){if(e=e||[],"[object Array]"===Object.prototype.toString.call(e)){for(var r=0;r<n.length;r++){var a=o(n[r]);l[a].references--}for(var u=i(e,t),s=0;s<n.length;s++){var c=o(n[s]);0===l[c].references&&(l[c].updater(),l.splice(c,1))}n=u}}}}},t={};function n(r){var a=t[r];if(void 0!==a)return a.exports;var l=t[r]={id:r,exports:{}};return e[r](l,l.exports,n),l.exports}n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{"use strict";var e=n(294),t=n(935),r=n(490),a={pub:function(e){a.subs[e]||(a.subs[e]=[]),a.subs[e].forEach((function(e){return e()}))},sub:function(e,t){a.subs[e]||(a.subs[e]=[]),a.subs[e].push(t)},subs:{}};$(document).ready((function(){$("body").append($('<div id="cookie-consent"></div>')),t.render(e.createElement(r.Z,{dispatcher:a}),document.getElementById("cookie-consent"))})),window.plosCookieConsentBanner={reopen:function(){a.pub("open")}}})()})(); </script>  <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-content/plugins/plos-elementor-widgets/assets/js/widgets.js?ver=0.0.1" id="plos-elementor-js"></script> <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-content/plugins/plos-elementor-widgets/assets/lib/slick-1.8.1/slick/slick.js?ver=1.8.1" id="slick-js"></script> <script type="text/javascript" src="https://absolutelymaybe.plos.org/wp-content/themes/plos/dist/scripts/main_2eafddd7.js?ver=0.0.8" id="sage/main.js-js"></script>  <script> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='//static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('init','o5hg7'); twq('track','PageView'); </script>  </body> </html>