PLOS Biologue - The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

<!doctype html> <html lang="en-US"> <head> <meta charset="utf-8"> <meta http-equiv="x-ua-compatible" content="ie=edge"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <script> const tracking = null; </script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>PLOS Biologue - The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.</title> <meta name="description" content="The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology." /> <link rel="canonical" href="https://biologue.plos.org/" /> <link rel="next" href="https://biologue.plos.org/page/2/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="website" /> <meta property="og:title" content="PLOS Biologue" /> <meta property="og:description" content="The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology." /> <meta property="og:url" content="https://biologue.plos.org/" /> <meta property="og:site_name" content="PLOS Biologue" /> <meta name="twitter:card" content="summary_large_image" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"CollectionPage","@id":"https://biologue.plos.org/","url":"https://biologue.plos.org/","name":"PLOS Biologue - The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.","isPartOf":{"@id":"https://biologue.plos.org/#website"},"description":"The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.","breadcrumb":{"@id":"https://biologue.plos.org/#breadcrumb"},"inLanguage":"en-US"},{"@type":"BreadcrumbList","@id":"https://biologue.plos.org/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home"}]},{"@type":"WebSite","@id":"https://biologue.plos.org/#website","url":"https://biologue.plos.org/","name":"PLOS Biologue","description":"The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://biologue.plos.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}</script>  <link rel='dns-prefetch' href='//biologue.plos.org' /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/biologue.plos.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://biologue.plos.org/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='safe-svg-svg-icon-style-inline-css' type='text/css'> .safe-svg-cover{text-align:center}.safe-svg-cover .safe-svg-inside{display:inline-block;max-width:100%}.safe-svg-cover svg{height:100%;max-height:100%;max-width:100%;width:100%} </style> <style id='co-authors-plus-coauthors-style-inline-css' type='text/css'> .wp-block-co-authors-plus-coauthors.is-layout-flow [class*=wp-block-co-authors-plus]{display:inline} </style> <style id='co-authors-plus-avatar-style-inline-css' type='text/css'> .wp-block-co-authors-plus-avatar :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-avatar :where(img){vertical-align:middle}.wp-block-co-authors-plus-avatar:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-avatar.aligncenter{display:table;margin-inline:auto} </style> <style id='co-authors-plus-image-style-inline-css' type='text/css'> .wp-block-co-authors-plus-image{margin-bottom:0}.wp-block-co-authors-plus-image :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-image :where(img){vertical-align:middle}.wp-block-co-authors-plus-image:is(.alignfull,.alignwide) :where(img){width:100%}.wp-block-co-authors-plus-image:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-image.aligncenter{display:table;margin-inline:auto} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){margin-left: auto !important;margin-right: auto !important;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='prefix-style-css' href='https://biologue.plos.org/wp-content/plugins/orcid-master/assets/orcid.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='sage/main.css-css' href='https://biologue.plos.org/wp-content/themes/plos/dist/styles/main_2eafddd7.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://biologue.plos.org/wp-content/themes/plos/resources/lib/scripts/jquery-3.5.1.min.js?ver=3.5.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://biologue.plos.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" src="https://biologue.plos.org/wp-content/plugins/orcid-master/assets/orcid.js?ver=6.6.2" id="orcid-javascript-js"></script> <link rel="https://api.w.org/" href="https://biologue.plos.org/wp-json/" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://biologue.plos.org/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.6.2" /> <style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style> <link href="https://fonts.googleapis.com/css?family=Merriweather:400,400i,900,900i|Roboto:400,400i,600,600i&display=swap" rel="stylesheet"> <link rel="apple-touch-icon" sizes="180x180" href="https://plos.org/wp-content/themes/plos/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://plos.org/wp-content/themes/plos/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://plos.org/wp-content/themes/plos/favicon/favicon-16x16.png"> <link rel="manifest" href="https://plos.org/wp-content/themes/plos/favicon/site.webmanifest"> <link rel="mask-icon" href="https://plos.org/wp-content/themes/plos/favicon/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="https://plos.org/wp-content/themes/plos/favicon/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="https://plos.org/wp-content/themes/plos/favicon/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> <style type="text/css"> header.app-header, .archive__header, .search__header { background-color: #ffffff; color: #00156b; } header.app-header a, .app-header__search-container input[type=search].search-form__field, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--prev a, .archive__header li.pagination__item--next a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item--page a, .search__header li.pagination__item--prev a, .search__header li.pagination__item--next a, .search__header a.pagination__mobile-link { color: #00156b; } .app-header__drawer-small-title, .app-header__container:after, .app-header__drawer:after, .app-header__nav-toggle span, .app-header__nav-toggle span:before, .app-header__nav-toggle span:after, a.app-header__nav-toggle span, a.app-header__nav-toggle span:before, a.app-header__nav-toggle span:after, ul.app-header__primary-nav > li.menu-item-has-children > a:after, ul.app-header__primary-nav > li.menu-item-has-children:hover > a:after, .app-header__search-container .search-form__label:before, .app-header__search-container .search-form__label:after, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a, ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--page a:hover, .archive__header li.pagination__item--page a:focus, .search__header li.pagination__item--page a, .search__header li.pagination__item--page a:hover, .search__header li.pagination__item--page a:focus { border-color: #00156b; } ul.app-header__primary-nav > li.current-menu-item > a:before, ul.app-header__primary-nav > li.current-page-ancestor > a:before { border-color: #ffffff; } .app-header .button.button--shortcode.button--s, .search__header input[type=submit] { border-color: #00156b; background: #00156b; color: #ffffff; } .app-header .button.button--shortcode.button--s:hover, .app-header .button.button--shortcode.button--s:focus, .search__header input[type=submit]:hover, .search__header input[type=submit]:focus { background: #00156b; color: #ffffff; opacity: 0.85; } ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a { background-color: #ffffff; } .app-header__drawer a:not(.post-list__post-image), .archive__header li.pagination__item a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item a, .search__header a.pagination__mobile-link { background-image: linear-gradient(#00156b, #00156b); } .app-header__drawer a:not(.post-list__post-image):hover, .app-header__drawer a:not(.post-list__post-image):focus, .archive__header li.pagination__item a:hover, .archive__header li.pagination__item a:focus, .archive__header a.pagination__mobile-link:hover, .archive__header a.pagination__mobile-link:focus, .search__header li.pagination__item a:hover, .search__header li.pagination__item a:focus, .search__header a.pagination__mobile-link:hover, .search__header a.pagination__mobile-link:focus { color: #ffffff; background-size: 100% 100%; background-position: 0% 100%; } .archive__header li.pagination__item--page.pagination__item--current a, .search__header li.pagination__item--page.pagination__item--current a { background-color: #00156b; border-color: #00156b; color: #ffffff; } .search__header form.search-form input[type=search] { background-color: #ffffff; border-color: #00156b; color: #00156b; } </style>  <script> /*! For license information please see head.js.LICENSE.txt */ (()=>{var e={773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var o,r=(o=n(808))&&o.__esModule?o:{default:o},i=n(773);function u(e){return Object.assign({},...i.VALID_PURPOSES.map((t=>({[t]:e}))))}var a={get:function(){try{const e=JSON.parse(r.default.get(i.COOKIE_KEY));return e?!0===e?u(!0):e:u(!1)}catch(e){return u(!1)}},isSet:function(){return void 0!==r.default.get(i.COOKIE_KEY)},remove:function(){r.default.remove(i.COOKIE_KEY)},set:function(e){const t=window.location.hostname;r.default.set(i.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:i.RECONSENT_INTERVAL})}};t.default=a},177:(e,t,n)=>{"use strict";t.default=void 0;var o,r=(o=n(502))&&o.__esModule?o:{default:o},i=n(773);function u(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,r.default.get())}var a={accept:function(){r.default.set(!0),u()},customize:function(e,t){r.default.set(Object.assign(r.default.get(),{[e]:t})),u()},hasConsented:function(e){if(!i.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+i.VALID_PURPOSES.toString());return r.default.get()[e]},hasInteracted:function(){return r.default.isSet()},reject:function(){r.default.set(!1),u()},reset:function(){r.default.remove()},VALID_PURPOSES:i.VALID_PURPOSES};t.default=a},808:(e,t,n)=>{var o,r,i;void 0===(r="function"==typeof(o=i=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var o in n)t[o]=n[o]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(o){function r(){}function i(t,n,i){if("undefined"!=typeof document){"number"==typeof(i=e({path:"/"},r.defaults,i)).expires&&(i.expires=new Date(1*new Date+864e5*i.expires)),i.expires=i.expires?i.expires.toUTCString():"";try{var u=JSON.stringify(n);/^[\{\[]/.test(u)&&(n=u)}catch(e){}n=o.write?o.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var a="";for(var c in i)i[c]&&(a+="; "+c,!0!==i[c]&&(a+="="+i[c].split(";")[0]));return document.cookie=t+"="+n+a}}function u(e,n){if("undefined"!=typeof document){for(var r={},i=document.cookie?document.cookie.split("; "):[],u=0;u<i.length;u++){var a=i[u].split("="),c=a.slice(1).join("=");n||'"'!==c.charAt(0)||(c=c.slice(1,-1));try{var s=t(a[0]);if(c=(o.read||o)(c,s)||t(c),n)try{c=JSON.parse(c)}catch(e){}if(r[s]=c,e===s)break}catch(e){}}return e?r[e]:r}}return r.set=i,r.get=function(e){return u(e,!1)},r.getJSON=function(e){return u(e,!0)},r.remove=function(t,n){i(t,"",e(n,{expires:-1}))},r.defaults={},r.withConverter=n,r}((function(){}))})?o.call(t,n,t,e):o)||(e.exports=r),e.exports=i()}},t={};function n(o){var r=t[o];if(void 0!==r)return r.exports;var i=t[o]={exports:{}};return e[o](i,i.exports,n),i.exports}(()=>{"use strict";var e=n(177);window.plosCookieConsent=e.default})()})(); </script>  </head> <body class="home blog app-data index-data home-data front-page-data elementor-default elementor-kit-16616"> <a class="skip-to-content" href="#content">Skip to content</a> <div id="top"></div> <header class="app-header"> <div class="app-header__container container"> <a class="app-header__brand" href=//plos.org> <img class="app-header__logo" src="https://biologue.plos.org/wp-content/uploads/2020/01/logo-sea.svg" alt="PLOS Biologue logo" /> </a> <nav class="app-header__nav"> <div class="app-header__nav-row"> <div class="app-header__primary-nav-container"> <div class="menu-header-navigation-container"><ul id="menu-header-navigation" class="app-header__primary-nav"><li id="menu-item-411" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-411"><a href="https://plos.org/publish/">Publish with PLOS</a> <ul class="sub-menu"> <li id="menu-item-9363" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9363"><a href="https://plos.org/your-journal-options/">Which Journal?</a></li> <li id="menu-item-1409" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1409"><a href="https://plos.org/publish/submit/">Submit</a></li> <li id="menu-item-2355" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2355"><a href="https://plos.org/publish/publishing-faqs/">Publishing FAQs</a></li> <li id="menu-item-2356" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2356"><a href="https://plos.org/publish/fees/">Fees</a></li> <li id="menu-item-2357" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2357"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-2358" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2358"><a href="https://plos.org/publish/metrics/">Metrics</a></li> <li id="menu-item-2359" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2359"><a href="https://plos.org/publish/funder-compliance/">Funder Compliance</a></li> <li id="menu-item-34242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34242"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> </ul> </li> <li id="menu-item-307" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-307"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-384" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-384"><a href="https://plos.org/open-science/">Open Science</a> <ul class="sub-menu"> <li id="menu-item-18582" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-18582"><a href="https://plos.org/open-science/open-access/">Open Access</a></li> <li id="menu-item-16399" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16399"><a href="https://plos.org/open-science/preprints/">Preprints</a></li> <li id="menu-item-17362" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17362"><a href="https://plos.org/open-science/open-data/">Open Data</a></li> <li id="menu-item-9918" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9918"><a href="https://plos.org/open-science/open-methods/">Open Methods</a></li> <li id="menu-item-7116" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7116"><a href="https://plos.org/protocols/">Protocols</a></li> <li id="menu-item-17916" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17916"><a href="https://plos.org/open-science/preregistration/">Preregistration</a></li> <li id="menu-item-17327" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-17327"><a href="https://plos.org/open-science/open-code/">Open Code</a></li> <li id="menu-item-2361" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2361"><a href="https://plos.org/published-peer-review-history/">Published Peer Review History</a></li> <li id="menu-item-16833" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16833"><a href="https://plos.org/open-science/credit/">Credit</a></li> </ul> </li> <li id="menu-item-260" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-260"><a href="https://plos.org/resources/">Resources</a> <ul class="sub-menu"> <li id="menu-item-692" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-692"><a href="https://plos.org/resources/for-institutions/">For Institutions</a></li> <li id="menu-item-5291" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5291"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-8642" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8642"><a href="https://plos.org/resources/editor-center/">Editor Center</a></li> <li id="menu-item-425" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-425"><a href="https://plos.org/resources/for-reviewers/">Peer Review Center</a></li> <li id="menu-item-16410" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16410"><a href="https://plos.org/research-by-plos/">Research by PLOS</a></li> <li id="menu-item-5004" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5004"><a href="https://plos.org/resources/writing-center/">Writing Center</a></li> </ul> </li> <li id="menu-item-420" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-420"><a href="https://plos.org/about/">About PLOS</a></li> </ul></div> </div> <div class="app-header__nav-controls"> <div class="app-header__search-container"> <form role="search" method="get" class="search-form" action="//plos.org"> <label class="search-form__label" for="s"><span class="screen-reader-text">Search:</span></label> <input type="search" class="search-form__field" value="" name="s" id="s" /> <input type="submit" class="search-form__submit" value="Search" /> </form> </div> <a class="app-header__nav-toggle" href="#"><span>Menu</span></a> </div> </div> </nav> </div> <div class="app-header__drawer"> <div class="app-header__drawer-container"> <div class="app-header__drawer-col app-header__drawer-content"> <div class="app-header__drawer-rich-text"> <p><span style="font-weight: 400;">When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.</span></p> <div class="acf-label"> <p class="description"></p> </div> </div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">Journals</span> <div class="menu-journals-container"><ul id="menu-journals" class="app-header__drawer-menu app-header__drawer-menu--1"><li id="menu-item-275" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-275"><a href="https://journals.plos.org/plosbiology/">PLOS Biology</a></li> <li id="menu-item-8531" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8531"><a href="https://journals.plos.org/climate">PLOS Climate</a></li> <li id="menu-item-31915" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31915"><a href="https://journals.plos.org/complexsystems/">PLOS Complex Systems</a></li> <li id="menu-item-276" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-276"><a href="https://journals.plos.org/ploscompbiol/">PLOS Computational Biology</a></li> <li id="menu-item-8535" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8535"><a href="https://journals.plos.org/digitalhealth">PLOS Digital Health</a></li> <li id="menu-item-277" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-277"><a href="https://journals.plos.org/plosgenetics/">PLOS Genetics</a></li> <li id="menu-item-8534" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8534"><a href="https://journals.plos.org/globalpublichealth">PLOS Global Public Health</a></li> <li id="menu-item-278" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-278"><a href="https://journals.plos.org/plosmedicine/">PLOS Medicine</a></li> <li id="menu-item-31916" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31916"><a href="https://journals.plos.org/mentalhealth/">PLOS Mental Health</a></li> <li id="menu-item-279" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-279"><a href="https://journals.plos.org/plosntds/">PLOS Neglected Tropical Diseases</a></li> <li id="menu-item-280" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-280"><a href="https://journals.plos.org/plosone/">PLOS ONE</a></li> <li id="menu-item-281" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-281"><a href="https://journals.plos.org/plospathogens/">PLOS Pathogens</a></li> <li id="menu-item-8533" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8533"><a href="https://journals.plos.org/sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li id="menu-item-8532" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8532"><a href="https://journals.plos.org/water">PLOS Water</a></li> </ul></div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">More Content</span> <div class="menu-more-content-container"><ul id="menu-more-content" class="app-header__drawer-menu app-header__drawer-menu--2"><li id="menu-item-282" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-282"><a href="https://plos.org/blogs/">PLOS Blogs</a></li> <li id="menu-item-283" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-283"><a href="https://collections.plos.org/">PLOS Collections</a></li> </ul></div> </div> </div> </div> </header> <style>.blog-header__background { background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2020/05/Biologue-blog-header2.jpg); }.blog-header__text { color: #ffffff }.blog-header__author-orcid { color: #ffffff }.blog-header__orcid-icon { background-color: #ffffff }</style><div class="blog-header"> <div class="blog-header__text"> <span class="blog-header__label">PLOS BLOGS</span> <a class="blog-header__blog-name" href="https://biologue.plos.org">PLOS Biologue</a> <p class="blog-header__blog-description">Welcome to PLOS Biologue – the blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.</p> <div class="blog-header__background"></div> </div> <div class="blog-header__blogs-navigation blogs-navigation"> <div class="blogs-navigation__container"> <a class="blogs-navigation__mobile-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__mobile-container"> <div class="blogs-navigation__main-menu-container"> <div class="menu-blog-navigation-container"><ul id="menu-blog-navigation" class="blogs-navigation__main-menu"><li id="menu-item-15926" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15926"><a href="https://biologue.plos.org/about/">About This Blog</a></li> <li id="menu-item-15925" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15925"><a href="https://biologue.plos.org/contact/">Contact</a></li> </ul></div> </div> <div class="blogs-navigation__drawer"> <a class="blogs-navigation__drawer-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__drawer-menu-container"> <div class="menu-blogs-menu-container"><ul id="menu-blogs-menu" class="blogs-navigation__drawer-menu"><li id="menu-item-3654" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-3654"><a href="#">Staff Blogs</a> <ul class="sub-menu"> <li id="menu-item-3655" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3655"><a href="https://theplosblog.plos.org">Official PLOS Blog</a></li> <li id="menu-item-3656" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3656"><a href="http://everyone.plos.org">EveryONE Blog</a></li> <li id="menu-item-9185" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9185"><a href="https://latitude.plos.org/">Latitude</a></li> <li id="menu-item-3657" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3657"><a href="https://speakingofmedicine.plos.org">Speaking of Medicine</a></li> <li id="menu-item-3658" class="menu-item menu-item-type-custom menu-item-object-custom current-menu-item menu-item-3658"><a href="https://biologue.plos.org" aria-current="page">PLOS Biologue</a></li> <li id="menu-item-3659" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3659"><a href="https://collectionsblog.plos.org/">PLOS Collections</a></li> </ul> </li> <li id="menu-item-3660" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3660"><a href="#">Independent Blogs</a> <ul class="sub-menu"> <li id="menu-item-3661" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3661"><a href="https://absolutelymaybe.plos.org">Absolutely Maybe</a></li> <li id="menu-item-3662" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3662"><a href="https://dnascience.plos.org">DNA Science</a></li> <li id="menu-item-3663" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3663"><a href="https://ecrcommunity.plos.org">PLOS ECR Community</a></li> <li id="menu-item-3664" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3664"><a href="https://scicomm.plos.org">SciComm</a></li> <li id="menu-item-3665" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3665"><a href="https://allmodels.plos.org">All Models Are Wrong</a></li> <li id="menu-item-3896" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3896"><a href="https://yoursay.plos.org">Your Say</a></li> </ul> </li> <li id="menu-item-3666" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3666"><a href="#">About</a> <ul class="sub-menu"> <li id="menu-item-3821" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3821"><a href="https://plos.org/blogs/about/">About PLOS Blogs</a></li> <li id="menu-item-3820" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3820"><a href="https://plos.org/blogs/contact/">Contact</a></li> </ul> </li> </ul></div> </div> </div> </div> </div> </div> </div> <div class="wrap" role="document"> <div class="content" id="content"> <main class="main"> <div class="archive"> <div class="archive__posts"> <form class="archive-filters archive__filters" data-permalink-base="https://biologue.plos.org"> <fieldset> <legend>Filter Posts</legend> <div class="archive-filters__container"> <div class="archive-filters__control-container"> <label for="archive-filters__control--search">Search</label> <input type="text" id="archive-filters__control--search" data-name="search" class="archive-filters__control" /> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--date">Year</label> <select id="archive-filters__control--date" data-name="date" class="archive-filters__control"> <option value="" >All years</option> <option value="2024" >2024</option> <option value="2023" >2023</option> <option value="2022" >2022</option> <option value="2021" >2021</option> <option value="2020" >2020</option> <option value="2019" >2019</option> <option value="2018" >2018</option> <option value="2017" >2017</option> <option value="2016" >2016</option> <option value="2015" >2015</option> <option value="2014" >2014</option> <option value="2013" >2013</option> <option value="2012" >2012</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--category">Category</label> <select id="archive-filters__control--category" data-name="category" class="archive-filters__control"> <option value="" >Show all</option> <option value="adipogenesis" >Adipogenesis</option> <option value="advocacy" >Advocacy</option> <option value="announcement" >Announcement</option> <option value="art" >Art</option> <option value="behind-the-paper" >Behind the paper</option> <option value="bioinformatics" >Bioinformatics</option> <option value="biology" >Biology</option> <option value="biotechnology" >Biotechnology</option> <option value="blog" >Blog</option> <option value="books" >Books</option> <option value="cancer" >Cancer</option> <option value="careers" >Careers</option> <option value="cell-biology" >Cell biology</option> <option value="cell-signalling" >Cell signalling</option> <option value="climate" >Climate</option> <option value="community" >Community</option> <option value="computational-biology" >Computational biology</option> <option value="conference" >Conference</option> <option value="conservation" >Conservation</option> <option value="data" >Data</option> <option value="debate" >Debate</option> <option value="developmental-biology" >Developmental biology</option> <option value="disease" >Disease</option> <option value="ecology" >Ecology</option> <option value="editorial-policy" >Editorial policy</option> <option value="education" >Education</option> <option value="einstein-awards-program" >Einstein Awards program</option> <option value="environment" >Environment</option> <option value="epigenetics" >Epigenetics</option> <option value="evolution" >Evolution</option> <option value="funding" >Funding</option> <option value="genetics" >Genetics</option> <option value="genomics" >Genomics</option> <option value="image" >Image</option> <option value="immunology" >Immunology</option> <option value="infectious-disease" >Infectious disease</option> <option value="interview" >Interview</option> <option value="journal-club" >Journal club</option> <option value="meet-your-editor" >Meet Your Editor</option> <option value="metrics" >Metrics</option> <option value="microbiology" >Microbiology</option> <option value="molecular-biology" >Molecular biology</option> <option value="neuroscience" >Neuroscience</option> <option value="news" >News</option> <option value="obituary" >Obituary</option> <option value="open-access" >Open access</option> <option value="outreach" >Outreach</option> <option value="plant-biology" >Plant biology</option> <option value="plos-biology" >PLOS Biology</option> <option value="plos-computational-biology" >PLOS Computational Biology</option> <option value="plos-genetics" >PLOS Genetics</option> <option value="policy" >Policy</option> <option value="psychedelic-science-neuroscience" >Psychedelic Science</option> <option value="publishing" >Publishing</option> <option value="regeneration" >Regeneration</option> <option value="research" >Research</option> <option value="resources" >Resources</option> <option value="review" >Review</option> <option value="science-communication" >Science communication</option> <option value="special-collections" >Special Collections</option> <option value="stem-cells" >Stem cells</option> <option value="systems-biology" >Systems biology</option> <option value="thought-leaders" >Thought Leaders</option> <option value="uncategorized" >Uncategorized</option> <option value="video" >Video</option> <option value="what-to-read-now" >What to Read Now</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--post_tag">Tag</label> <select id="archive-filters__control--post_tag" data-name="post_tag" class="archive-filters__control"> <option value="" >Show all</option> <option value="10th-anniversary" >10th Anniversary</option> <option value="aacr" >AACR</option> <option value="academic-editors" >Academic editors</option> <option value="academic-life" >academic life</option> <option value="adipogenesis" >Adipogenesis</option> <option value="advisory-board" >Advisory board</option> <option value="african-lions" >African lions</option> <option value="african-sleeping-sickness" >African sleeping sickness</option> <option value="agriculture" >agriculture</option> <option value="algae" >algae</option> <option value="allostery" >allostery</option> <option value="allostery-data-integration" >allostery; data integration;</option> <option value="alzheimers" >Alzheimers</option> <option value="amyloid" >amyloid</option> <option value="animal-genetics" >animal genetics</option> <option value="animal-research" >animal research</option> <option value="announcement-2" >announcement</option> <option value="anti-cancer-drugs" >anti-cancer drugs</option> <option value="antibiotic-resistance" >Antibiotic Resistance</option> <option value="antioxidants" >antioxidants</option> <option value="article-level-metrics" >Article-level metrics</option> <option value="associate-editor" >Associate Editor</option> <option value="authors" >authors</option> <option value="b-cells" >B cells</option> <option value="bats" >Bats</option> <option value="behind-the-paper" >behind the paper</option> <option value="biodiversity" >Biodiversity</option> <option value="bioinformatics-2" >bioinformatics</option> <option value="biology-2" >biology</option> <option value="biomedicine" >Biomedicine</option> <option value="black-in-marine-science" >black in marine science</option> <option value="blog" >blog</option> <option value="book-reivew" >Book reivew</option> <option value="book-review" >Book Review</option> <option value="books-2" >books</option> <option value="brain-dynamics" >brain dynamics</option> <option value="brca1" >BRCA1</option> <option value="breast-cancer" >Breast Cancer</option> <option value="butterfly" >butterfly</option> <option value="call-for-papers" >Call for papers</option> <option value="cancer-2" >cancer</option> <option value="canine" >canine</option> <option value="careers" >Careers</option> <option value="carnivore" >carnivore</option> <option value="ccd" >CCD</option> <option value="cecil" >Cecil</option> <option value="cell-biology" >cell biology</option> <option value="cell-dynamics" >Cell dynamics</option> <option value="cell-migration" >Cell migration</option> <option value="cell-signaling" >cell signaling</option> <option value="cellular-networks" >cellular networks</option> <option value="charles-darwin" >charles darwin</option> <option value="chemistry" >Chemistry</option> <option value="chimpanzee" >chimpanzee</option> <option value="chlorpyrifos" >chlorpyrifos</option> <option value="chromatin" >Chromatin</option> <option value="chromosome-dynamics" >chromosome dynamics</option> <option value="chromosome-stability" >Chromosome Stability</option> <option value="circadian-rhythms" >circadian rhythms</option> <option value="citations" >citations</option> <option value="climate" >climate</option> <option value="climate-change" >climate change</option> <option value="co-evolution" >Co-evolution</option> <option value="code" >code</option> <option value="collaboration" >collaboration</option> <option value="collany-collapse-disorder" >collany collapse disorder</option> <option value="collection" >collection</option> <option value="colony-collapse" >colony collapse</option> <option value="communication" >communication</option> <option value="community-2" >community</option> <option value="community-engagement" >community engagement</option> <option value="computational" >computational</option> <option value="computational-biology-2" >computational biology</option> <option value="computational-models" >computational models</option> <option value="conference" >Conference</option> <option value="conference-sponsorship" >conference sponsorship</option> <option value="conferences" >conferences</option> <option value="conflict" >conflict</option> <option value="conflicts-of-interest" >conflicts of interest</option> <option value="connectome" >connectome</option> <option value="conservation" >conservation</option> <option value="conservation-biology" >conservation biology</option> <option value="conservation-science" >conservation science</option> <option value="covid-19" >COVID-19</option> <option value="cpg-islands" >CpG islands</option> <option value="crispr" >CRISPR</option> <option value="darwin" >darwin</option> <option value="data" >Data</option> <option value="data-access" >data access</option> <option value="deep-reads" >Deep Reads</option> <option value="dei" >DEI</option> <option value="developmental-biology" >developmental biology</option> <option value="diversity-in-science" >diversity in science</option> <option value="dna" >DNA</option> <option value="dna-sequencing" >DNA sequencing</option> <option value="dogs" >dogs</option> <option value="drosophila" >drosophila</option> <option value="drumming" >drumming</option> <option value="dryad" >Dryad</option> <option value="early-career-researchers" >Early Career Researchers</option> <option value="early-career-scientists" >early career scientists</option> <option value="ebola" >ebola</option> <option value="ecology" >Ecology</option> <option value="economics" >Economics</option> <option value="ecotourism" >ecotourism</option> <option value="editing" >Editing</option> <option value="editor" >editor</option> <option value="editorial-board" >Editorial Board</option> <option value="editorial-policy-2" >editorial policy</option> <option value="editorial-process" >editorial process</option> <option value="education" >Education</option> <option value="einstein-awards" >Einstein Awards</option> <option value="electric-images" >Electric Images</option> <option value="electrograms" >electrograms</option> <option value="embryo" >embryo</option> <option value="endangered-species" >endangered species</option> <option value="environment" >environment</option> <option value="environmental-health" >environmental health</option> <option value="epidemiology" >epidemiology</option> <option value="epigenetics-2" >epigenetics</option> <option value="eqtl" >eQTL</option> <option value="evolution-2" >evolution</option> <option value="ewas" >EWAS</option> <option value="ewpc2017" >EWPC2017</option> <option value="experimental-psychiatry" >experimental psychiatry</option> <option value="extreme-weather" >extreme weather</option> <option value="flame-retardants" >flame retardants</option> <option value="flowers" >Flowers</option> <option value="flu" >flu</option> <option value="fly" >Fly</option> <option value="fly-research" >fly research</option> <option value="focus-feature" >Focus Feature</option> <option value="foia" >FOIA</option> <option value="fossils" >fossils</option> <option value="freedom-of-information-act" >freedom of information act</option> <option value="functional-connectivity" >functional connectivity</option> <option value="fungal-genetics" >Fungal Genetics</option> <option value="fungus" >Fungus</option> <option value="gene" >Gene</option> <option value="gene-expression" >gene expression</option> <option value="gene-ontology" >gene ontology</option> <option value="genetic-loci" >genetic loci</option> <option value="genetic-testing" >Genetic Testing</option> <option value="genetics-2" >genetics</option> <option value="genomics" >genomics</option> <option value="georgina-mace" >Georgina Mace</option> <option value="github" >Github</option> <option value="global-health" >Global Health</option> <option value="gordon-research-conference" >Gordon Research Conference</option> <option value="h-index" >H-index</option> <option value="h-trajectory" >H-trajectory</option> <option value="hair" >hair</option> <option value="hair-loss" >hair loss</option> <option value="haplotypes" >haplotypes</option> <option value="healing" >Healing</option> <option value="health" >health</option> <option value="heat-shock-proteins" >heat shock proteins</option> <option value="hematopoiesis" >hematopoiesis</option> <option value="highlights" >Highlights</option> <option value="hivaids" >HIV/AIDS</option> <option value="honey-bee" >honey bee</option> <option value="honeybee" >honeybee</option> <option value="human-brain" >human brain</option> <option value="immune-response" >immune response</option> <option value="immunology" >immunology</option> <option value="infectious-disease-2" >Infectious Disease</option> <option value="influenza" >Influenza</option> <option value="interview" >interview</option> <option value="iscb" >ISCB</option> <option value="ismb" >ISMB</option> <option value="ismb2014" >ISMB2014</option> <option value="issue-image" >Issue Image</option> <option value="james-rosindell" >James Rosindell</option> <option value="jonathan-eisen" >Jonathan Eisen</option> <option value="journalism" >journalism</option> <option value="keystone-symposia" >Keystone symposia</option> <option value="launch" >launch</option> <option value="leaves" >leaves</option> <option value="literature" >literature</option> <option value="low-dose-exposures" >low dose exposures</option> <option value="luke-harmon" >Luke Harmon</option> <option value="machine-learning" >Machine learning</option> <option value="macromolecular" >macromolecular</option> <option value="malaria" >malaria</option> <option value="marine-biology" >marine biology</option> <option value="maternal-and-child-health" >maternal and child health</option> <option value="maternal-transmission" >maternal transmission</option> <option value="media-response" >Media response</option> <option value="meet-the-editors" >Meet the Editors</option> <option value="meiosis" >meiosis</option> <option value="memory" >memory</option> <option value="meta-research" >Meta-research</option> <option value="metabolism" >Metabolism</option> <option value="metagenomics" >Metagenomics</option> <option value="methods" >Methods</option> <option value="methylation" >methylation</option> <option value="microbiology" >microbiology</option> <option value="microbiome" >Microbiome</option> <option value="microbiomes" >microbiomes</option> <option value="microrna" >microRNA</option> <option value="milestone" >Milestone</option> <option value="modelling" >modelling</option> <option value="molecular-biology-2" >Molecular Biology</option> <option value="mountain-lions" >mountain lions</option> <option value="mouse-models" >Mouse Models</option> <option value="mozilla" >Mozilla</option> <option value="multidrug-resistance" >multidrug resistance</option> <option value="natural-disasters" >natural disasters</option> <option value="nature" >nature</option> <option value="neglected-tropical-diseases" >neglected tropical diseases</option> <option value="nematodes" >nematodes</option> <option value="neural-cicuits" >neural cicuits</option> <option value="neuroimaging" >Neuroimaging</option> <option value="neuroprosthetics" >Neuroprosthetics</option> <option value="neuroscience" >Neuroscience</option> <option value="neurotoxicants" >neurotoxicants</option> <option value="new-article-types" >New Article Types</option> <option value="news-2" >news</option> <option value="nobel-laureates" >Nobel Laureates</option> <option value="nobel-prize" >Nobel Prize</option> <option value="november-issue" >November issue</option> <option value="nrem-sleep" >NREM sleep</option> <option value="ntds" >NTDs</option> <option value="ocean-collection" >ocean collection</option> <option value="oceans" >oceans</option> <option value="october-issue" >October issue</option> <option value="oncogene" >oncogene</option> <option value="onezoom" >OneZoom</option> <option value="open-access" >open access</option> <option value="open-data" >open data</option> <option value="open-for-a-reason" >Open for a reason</option> <option value="open-science" >open science</option> <option value="outreach-2" >outreach</option> <option value="outside-the-box" >Outside The Box</option> <option value="parkinsons" >Parkinsons</option> <option value="pathogens" >pathogens</option> <option value="pearls" >Pearls</option> <option value="peer-review" >peer review</option> <option value="perfluoroalkyl-acids" >perfluoroalkyl acids</option> <option value="perspective" >perspective</option> <option value="pesticides" >pesticides</option> <option value="petals" >petals</option> <option value="phaser-cells" >Phaser Cells</option> <option value="phylogenetic-tree" >phylogenetic tree</option> <option value="physician-payment-sunshine-act" >Physician Payment Sunshine Act</option> <option value="plant" >Plant</option> <option value="plant-genetics" >Plant Genetics</option> <option value="plants" >Plants</option> <option value="plos" >PLOS</option> <option value="plos-biologue" >PLoS Biologue</option> <option value="plos-biology-2" >PLoS Biology</option> <option value="plos-biology-advisory-board" >PLOS Biology Advisory Board</option> <option value="plos-biology-icymi" >PLOS Biology ICYMI</option> <option value="plos-collections" >PLOS Collections</option> <option value="plos-computational-biology" >PLOS Computational Biology</option> <option value="plos-genetics" >PLOS Genetics</option> <option value="plos-genetics-conference-sponsorship" >PLOS Genetics Conference Sponsorship</option> <option value="plos-genetics-conference-support" >PLOS Genetics Conference Support</option> <option value="plos-genetics-research-prize-announcement" >PLOS Genetics Research Prize; Announcement</option> <option value="plos-medicine" >PLOS Medicine</option> <option value="plos-one" >PLOS ONE</option> <option value="plos-pathogens" >plos pathogens</option> <option value="plosbio15" >PLOSBio15</option> <option value="podcasts" >podcasts</option> <option value="policy" >policy</option> <option value="preregistration" >preregistration</option> <option value="presubmission-enquiry" >presubmission enquiry</option> <option value="privacy" >privacy</option> <option value="prostate-cancer" >prostate cancer</option> <option value="protein-complex-prediction" >Protein Complex Prediction</option> <option value="proteins" >proteins</option> <option value="protocols" >protocols</option> <option value="protocols-io" >protocols.io</option> <option value="psychedelics" >psychedelics</option> <option value="psychiatry" >psychiatry</option> <option value="psychology" >psychology</option> <option value="public-health" >Public Health</option> <option value="public-interest" >public interest</option> <option value="public-records" >public records</option> <option value="publishing" >publishing</option> <option value="publishing-advice" >publishing advice</option> <option value="recomb-2014" >RECOMB 2014</option> <option value="regulation" >regulation</option> <option value="replication" >replication</option> <option value="reproducibility" >reproducibility</option> <option value="research-2" >research</option> <option value="research-perfomance" >research perfomance</option> <option value="research-prize" >Research Prize</option> <option value="research-replication" >research replication</option> <option value="review-2" >review</option> <option value="rio20" >Rio+20</option> <option value="round-up" >Round up</option> <option value="russ-altman" >Russ Altman</option> <option value="ruth-nussinov" >Ruth Nussinov</option> <option value="science-communication" >science communication</option> <option value="science-labs" >science labs</option> <option value="science-publishing" >science publishing</option> <option value="scientific-bias" >scientific bias</option> <option value="service" >service</option> <option value="shape" >shape</option> <option value="single-cell-rna-sequencing" >single cell RNA-sequencing</option> <option value="single-celled-organism" >single celled organism</option> <option value="skin-infection" >Skin Infection</option> <option value="sleep" >sleep</option> <option value="slice-of-plos" >Slice of PLOS</option> <option value="social-genetics-effects" >social genetics effects</option> <option value="software" >software</option> <option value="species" >species</option> <option value="speech-comprehension" >speech comprehension</option> <option value="statistics" >statistics</option> <option value="stem-cells-2" >stem cells</option> <option value="stickleback" >stickleback</option> <option value="storify" >storify</option> <option value="storytelling" >storytelling</option> <option value="structure-and-dynamics" >structure and dynamics</option> <option value="student-symposium" >Student Symposium</option> <option value="sustainability" >sustainability</option> <option value="sustainability-collection" >sustainability collection</option> <option value="symbionts" >Symbionts</option> <option value="symposium" >symposium</option> <option value="synthetic-biology" >synthetic biology</option> <option value="systematics" >systematics</option> <option value="systems-biology" >systems biology</option> <option value="t-cell" >T cell</option> <option value="t-shirt-design" >t-shirt design</option> <option value="tb" >TB</option> <option value="ten-simple-rules" >Ten Simple Rules</option> <option value="tenth-anniversary" >tenth anniversary</option> <option value="theo-bloom" >Theo Bloom</option> <option value="topic-pages" >Topic Pages</option> <option value="toxicology" >toxicology</option> <option value="translational-bioinformatics" >Translational Bioinformatics</option> <option value="transparency" >transparency</option> <option value="tree-of-life" >tree of life</option> <option value="trophy-hunting" >trophy hunting</option> <option value="tuberculosis" >Tuberculosis</option> <option value="understanding-images" >Understanding images</option> <option value="union-of-concerned-scientists" >Union of Concerned Scientists</option> <option value="university-of-california-berkeley" >University of California Berkeley</option> <option value="vaccine" >Vaccine</option> <option value="vaccines" >vaccines</option> <option value="vampire-bats" >vampire bats</option> <option value="vcs" >VCS</option> <option value="virus" >virus</option> <option value="wikipedia" >Wikipedia</option> <option value="wolbachia" >Wolbachia</option> <option value="women-in-science" >women in science</option> <option value="woodpeckers" >woodpeckers</option> <option value="wound" >Wound</option> <option value="yeast" >Yeast</option> </select> </div> <div class="archive-filters__submit-container"> <input type="submit" value="Go" /> </div> <div class="archive-filters__view-controls"> <span class="archive-filters__view-label">View Style</span> <ul> <li><a class="archive-filters__view-control archive-filters__view-control--grid" data-style="grid">Grid view</a></li> <li><a class="archive-filters__view-control archive-filters__view-control--list archive-filters__view-control--active" data-style="list">List view</a></li> </ul> </div> </div> <div class="archive-filters__rss"> <span class="archive-filters__rss-label">Follow this Blog</span> <br /> <a class="archive-filters__rss-link" href="https://biologue.plos.org/feed/"><i class="fas fa-rss"></i> RSS</a> </div> </fieldset> </form> <ul class="post-list post-list--list post-list--non-elementor" id="posts"> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2024/11/04/remembering-barbara-cohens-impact-on-scientific-publishing/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2024/11/Cohen.png);" title="Remembering Barbara Cohen’s Impact on Scientific Publishing"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Obituary</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2024/11/04/remembering-barbara-cohens-impact-on-scientific-publishing/">Remembering Barbara Cohen’s Impact on Scientific Publishing</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 4, 2024</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/asnider/">Audrey Snider</a></span> </div> <div class="post-list__post-excerpt"> <p>Image caption: Barbara Cohen, a founding editor of PLOS, died on October 21, 2024, in Asturias, Spain (photo credit: Sandra Aamodt). About…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2024/11/04/remembering-barbara-cohens-impact-on-scientific-publishing/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2024/05/08/biological-life-science-research-2024/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2023/03/690x320_BioSci_blog-header.png);" title="Discover the latest Biological and Life Sciences Research"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Biology</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2024/05/08/biological-life-science-research-2024/">Discover the latest Biological and Life Sciences Research</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">May 8, 2024</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/davidknutson/">PLOS</a></span> </div> <div class="post-list__post-excerpt"> <p>Our portfolio of biological and life sciences journals continue to push the boundaries of research and research communication. Discover the latest papers…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2024/05/08/biological-life-science-research-2024/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2024/04/22/behind-the-paper-why-we-cannot-tell-different-types-of-species-interaction-networks-apart/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: why we cannot tell different types of species interaction networks apart"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Behind the paper</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2024/04/22/behind-the-paper-why-we-cannot-tell-different-types-of-species-interaction-networks-apart/">Behind the paper: why we cannot tell different types of species interaction networks apart</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">April 22, 2024</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Chris Brimacombe discusses why it is so difficult to study the structure of species interaction networks…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2024/04/22/behind-the-paper-why-we-cannot-tell-different-types-of-species-interaction-networks-apart/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2024/04/02/reflecting-the-past-a-fond-farewell-to-the-gregs/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-10.gif);" title="Reflecting the past: A Fond Farewell to The Gregs"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Genetics</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2024/04/02/reflecting-the-past-a-fond-farewell-to-the-gregs/">Reflecting the past: A Fond Farewell to The Gregs</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">April 2, 2024</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/davidknutson/">PLOS</a></span> </div> <div class="post-list__post-excerpt"> <p>Author: Julia Squarr, Journal Development Manager, PLOS Pathogens and PLOS Genetics PLOS Genetics finds itself at a juncture marked by both reflection…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2024/04/02/reflecting-the-past-a-fond-farewell-to-the-gregs/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/11/22/behind-the-paper-neuronal-activity-can-drive-cerebrospinal-fluid-flow-in-the-human-brain/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: neuronal activity can drive cerebrospinal fluid flow in the human brain"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Behind the paper</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/11/22/behind-the-paper-neuronal-activity-can-drive-cerebrospinal-fluid-flow-in-the-human-brain/">Behind the paper: neuronal activity can drive cerebrospinal fluid flow in the human brain</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 22, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Stephanie Williams discusses how the new equipment, techniques and methods developed in her lab helped them…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/11/22/behind-the-paper-neuronal-activity-can-drive-cerebrospinal-fluid-flow-in-the-human-brain/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/11/15/behind-the-paper-why-collaboration-is-key-to-studying-the-brain/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: why collaboration is key to studying the brain"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Behind the paper</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/11/15/behind-the-paper-why-collaboration-is-key-to-studying-the-brain/">Behind the paper: why collaboration is key to studying the brain</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 15, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Joe Ziminski discusses his collaborative experience while studying how our brain changes when we learn. The…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/11/15/behind-the-paper-why-collaboration-is-key-to-studying-the-brain/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/10/31/kasturi-haldars-plos-pathogens-journey-a-farewell-tribute/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-1.gif);" title="Kasturi Haldar’s PLOS Pathogens Journey: A Farewell Tribute"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Announcement</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/10/31/kasturi-haldars-plos-pathogens-journey-a-farewell-tribute/">Kasturi Haldar’s PLOS Pathogens Journey: A Farewell Tribute</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 31, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/davidknutson/">PLOS</a></span> </div> <div class="post-list__post-excerpt"> <p>Dear Friends and Colleagues, As we bid adieu to Kasturi, we do so with a profound sense of gratitude for her unwavering…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/10/31/kasturi-haldars-plos-pathogens-journey-a-farewell-tribute/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/10/25/latest-biological-science-research/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2023/03/690x320_BioSci_blog-header.png);" title="Explore the latest research making an impact in your field"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Biology</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/10/25/latest-biological-science-research/">Explore the latest research making an impact in your field</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 25, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/davidknutson/">PLOS</a></span> </div> <div class="post-list__post-excerpt"> <p>Our biological science research journals cover a broad range of topics, from animal biology and plant science to genetic engineering, immunology, and…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/10/25/latest-biological-science-research/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/10/11/the-relationship-between-an-oncometabolite-and-propionate-degradation-in-nematodes/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: The relationship between an oncometabolite and propionate degradation in nematodes"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Behind the paper</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/10/11/the-relationship-between-an-oncometabolite-and-propionate-degradation-in-nematodes/">Behind the paper: The relationship between an oncometabolite and propionate degradation in nematodes</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 11, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Olga Ponomarova discusses how testing many diverse hypothesis brought them to find the relationship between apparently…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/10/11/the-relationship-between-an-oncometabolite-and-propionate-degradation-in-nematodes/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/09/11/navigating-my-scientific-journey/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2023/09/road-6625315_1280-1024x854.jpg);" title="Navigating my scientific journey: the guiding light of a PLOS Biology paper"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Careers</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/09/11/navigating-my-scientific-journey/">Navigating my scientific journey: the guiding light of a PLOS Biology paper</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">September 11, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>As we celebrate our 20th anniversary, Lisa Maier shares the story of how one PLOS Biology paper set the course for her…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/09/11/navigating-my-scientific-journey/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/08/16/courage-is-the-best-magic/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: Courage is the best magic"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Adipogenesis</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/08/16/courage-is-the-best-magic/">Behind the paper: Courage is the best magic</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">August 16, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Yuting Lei discusses how he overcome several technical difficulties in his search for the adult fat…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/08/16/courage-is-the-best-magic/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://biologue.plos.org/2023/08/09/making-sense-of-language-under-a-grander-context/" style="background-image: url(https://biologue.plos.org/wp-content/uploads/sites/7/2022/06/a-book-4293682_1920-1024x565.jpg);" title="Behind the paper: Making sense of language under a grander context"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Behind the paper</span> <span class="post-list__post-title"> <a href="https://biologue.plos.org/2023/08/09/making-sense-of-language-under-a-grander-context/">Behind the paper: Making sense of language under a grander context</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">August 9, 2023</span> <span class="post-list__post-author">By <a href="https://biologue.plos.org/author/plosbiologyeditors/">PLOS Biology</a></span> </div> <div class="post-list__post-excerpt"> <p>In this ‘behind the paper’ post, Yaqing Su discusses how the lockdown and the pandemic redirected her thoughts in developing a model…</p> </div> <a class="post-list__post-read-more" href="https://biologue.plos.org/2023/08/09/making-sense-of-language-under-a-grander-context/">Read more</a> </div> </li> </ul> </div> <div class="archive__pagination archive__pagination--bottom"> <span class="archive__pagination-count">Showing 1 – 12 of 460 posts</span> <div class="pagination"> <ul class="pagination__list"> <li class="pagination__item pagination__item--prev pagination__item--inactive pagination__item--not-current"> <a>Prev</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--current"> <a href="/">1</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/2/">2</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/3/">3</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/4/">4</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/5/">5</a> </li> <li class="pagination__item pagination__item--dots pagination__item--inactive pagination__item--not-current"> <span class="pagination__dots">...</span> </li> <li class="pagination__item pagination__item--next pagination__item--active pagination__item--not-current"> <a href="/page/2/">Next</a> </li> </ul> <div class="pagination__mobile"> <div class="pagination__link"> <a href="" class="pagination__mobile-link pagination__mobile-link--inactive">Prev</a> </div> <div class="pagination__select-container"> <select class="pagination__select" data-total-pages="39"> <option value="/" selected>1</option> <option value="/page/2/" >2</option> <option value="/page/3/" >3</option> <option value="/page/4/" >4</option> <option value="/page/5/" >5</option> </select> </div> <div class="pagination__link"> <a href="/page/2/" class="pagination__mobile-link pagination__mobile-link--active">Next</a> </div> </div> </div> </div> </div> </main> </div> </div> <style type="text/css"> footer.app-footer { background-color: #050c2b; color: #ffffff; } footer.app-footer a, footer.app-footer label { color: #ffffff; } footer.app-footer input[type=text], footer.app-footer input[type=email] { background-color: #050c2b; border-color: #ffffff; color: #ffffff; } </style> <footer class="app-footer"> <div class="app-footer__container container"> <div class="app-footer__col app-footer__branding"> <a class="app-footer__brand" href="https://biologue.plos.org/"> <img class="app-footer__logo" src="https://biologue.plos.org/wp-content/uploads/2019/12/logo-white.svg" alt="PLOS Biologue logo" /> </a> <ul class="social-media-links app-footer__social-media-links"> <li class="social-media-links__item social-media-links__item--twitter"> <a class="social-media-links__link" href="https://twitter.com/plos"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="twitter-icon-title"> <title id="twitter-icon-title">X (former Twitter)</title> <style type="text/css">.svg-twitter-fill{fill: #ffffff;}</style> <path class="svg-twitter-fill" d="M11.7,8.6L18.2,1h-1.6L11,7.6L6.4,1H1.2l6.9,10l-6.9,8h1.6l6-7l4.8,7h5.2L11.7,8.6L11.7,8.6z M9.5,11.1l-0.7-1L3.3,2.2h2.4l4.5,6.4l0.7,1l5.8,8.3h-2.4L9.5,11.1L9.5,11.1z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--facebook"> <a class="social-media-links__link" href="https://www.facebook.com/PLoS.org"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="facebook-icon-title"> <title id="facebook-icon-title">Facebook</title> <style type="text/css">.svg-facebook-fill{fill: #ffffff;}</style> <path class="svg-facebook-fill" d="M19.5 1.5v16.6c0 0.6-0.5 1.2-1.2 1.2h-4.8v-7.4h2.4l0.4-2.7h-2.8V7.1c0-0.8 0.4-1.2 1.2-1.2h1.8V3.4c0 0-0.8-0.1-1.9-0.1 -2.6 0-3.9 1.4-3.9 3.6v2.4H8.3v2.7h2.4v7.4h-9c-0.6 0-1.2-0.5-1.2-1.2V1.5c0-0.6 0.5-1.2 1.2-1.2h16.6C19 0.3 19.5 0.9 19.5 1.5z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--linkedin"> <a class="social-media-links__link" href="https://www.linkedin.com/company/public-library-of-science"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="linkedin-icon-title"> <title id="linkedin-icon-title">Linkedin</title> <style type="text/css">.svg-linkedin-fill{fill: #ffffff;}</style> <path class="svg-linkedin-fill" d="M2.9 5.1L2.9 5.1c-1.4 0-2.4-1-2.4-2.2 0-1.2 0.9-2.2 2.4-2.2 1.4 0 2.3 0.9 2.4 2.2C5.2 4.1 4.3 5.1 2.9 5.1zM4.9 7.1v12.3h-4V7.1H4.9zM11.2 19.3h-4V9.8c0 0-0.1-2.4-0.1-2.8h3.9l0.1 1.7c0.8-1.2 2-2.1 3.6-2.1 2.8 0 4.8 2 4.8 5.5v7.1h-4v-6.7c0-2-1-2.8-2.2-2.8 -1.2 0-2.2 0.8-2.2 2.4V19.3z"/> </svg> </a> </li> </ul> <span class="app-footer__info-text">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, and is based in California, US</span> </div> <div class="app-footer__col app-footer__nav"> <div class="app-footer__nav-container"> <div class="menu-footer-navigation-container"><ul id="menu-footer-navigation" class="app-header__footer-nav"><li id="menu-item-1680" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1680"><a href="https://plos.org/">Home</a></li> <li id="menu-item-309" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-309"><a href="https://plos.org/resources/">Resources</a></li> <li id="menu-item-308" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-308"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-383" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-383"><a href="https://plos.org/open-science/">Open Science</a></li> <li id="menu-item-412" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-412"><a href="https://plos.org/publish/">Publish with PLOS</a></li> <li id="menu-item-419" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-419"><a href="https://plos.org/about/">About PLOS</a></li> <li id="menu-item-34241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34241"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> <li id="menu-item-8117" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8117"><a href="https://plos.org/dei/">Diversity, Equity and Inclusion</a></li> <li id="menu-item-2817" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2817"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-1682" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1682"><a href="https://plos.org/about/contact/">Contact</a></li> <li id="menu-item-1683" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1683"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-1684" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1684"><a href="https://plos.org/careers/">Careers</a></li> <li id="menu-item-1685" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1685"><a href="https://plos.org/advertise/">Advertise</a></li> <li id="menu-item-35167" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-35167"><a href="https://plos.org/financial-overview/">Financial Overview</a></li> <li id="menu-item-25042" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-25042"><a href="https://plos.org/governance/">Governance</a></li> <li id="menu-item-1687" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-1687"><a rel="privacy-policy" href="https://plos.org/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-15441" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15441"><a href="https://plos.org/cookies-policy/">Cookie Policy</a></li> <li id="menu-item-1688" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1688"><a href="https://plos.org/terms-of-use/">Terms of Use</a></li> <li id="menu-item-7340" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7340"><a href="https://plos.org/payment-terms-and-conditions/">Payment Terms and Conditions</a></li> <li id="menu-item-1689" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1689"><a href="https://plos.org/text-and-data-mining/">Text & Data Mining</a></li> <li id="menu-item-11315" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11315"><a href="https://plos.org/terms-of-service/">Terms of Service</a></li> </ul></div> </div> </div> <div class="app-footer__col app-footer__rich-text"> <p><strong>News & Updates</strong></p> <form class="newsletter-signup" action="https://cl.exct.net/subscribe.aspx" name="subscribeForm" method="post"><input type="hidden" name="thx" value="https://www.plos.org/signup-success/"><input type="hidden" name="err" value="https://www.plos.org/signup-error/"><input type="hidden" name="SubAction" value="sub"><input type="hidden" name="MID" value="7207856"><input type="hidden" name="LID" value="5488"><input type="hidden" name="Source" value="WebCollect"><div class="newsletter-signup__input-container newsletter-signup__input-container--text-container"><label for="email-address">Email address</label><input type="email" id="email-address" name="Email Address"></div><div class="newsletter-signup__input-container newsletter-signup__input-container--checkbox-container"><span class="newsletter-signup__disclaimer">PLOS will use your email address to provide news and updates. You can find out more about how PLOS processes your data by reading our <a href="https://plos.org/privacy-policy/">Privacy Policy</a>. You can unsubscribe at any time by clicking the unsubscribe link in our emails or by contacting us at privacy@plos.org.</span></div><div class="newsletter-signup__input-container newsletter-signup__input-container--submit-container"><small class="newsletter-signup__validation-message">All fields are required, please check your entry and try again.</small><input type="submit" value="Submit"></div></form> </div> </div> </footer> <a class="back-to-top" id="back-to-top" href="#top"><span class="screen-reader-text">Back to top</span></a>  <script> /*! For license information please see body.js.LICENSE.txt */ (()=>{var e={490:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}t.Z=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(682)),i=u(n(628));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.Z=function(e){var t,n,r=e.dispatcher,u=(t=(0,a.useState)(!l.default.hasInteracted()),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),s=u[0],f=u[1];return r&&(0,a.useEffect)((function(){return r.sub("open",(function(){return f(!0)}))}),[]),a.default.createElement("div",{className:"cookie-consent"},a.default.createElement(o.default,{show:s}),a.default.createElement(i.default,{close:function(){f(!1)},show:s}))}},682:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=n(357),l=o(n(188));function o(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.show;return r.default.createElement(a.CSSTransition,{in:t,timeout:200,classNames:{enter:l.default.fadeInEnter,enterActive:l.default.fadeInEnterActive,exit:l.default.fadeInExit,exitActive:l.default.fadeInExitActive},unmountOnExit:!0},r.default.createElement("div",{className:l.default.overlay,role:"presentation"}))}},980:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0,t.default="data:image/svg+xml;charset=utf-8;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg enable-background="new 0 0 944 620" version="1.1" viewBox="0 0 944 620" xml:space="preserve" xmlns="http://www.w3.org/2000/svg">
<style type="text/css">
  .st0{fill:#F63C3D;}
  .st1{fill:#17BAFA;}
  .st2{opacity:0.93;}
  .st3{fill:#18335A;}
  .st4{fill:#D2DA20;}
  .st5{opacity:0.83;}
  .st6{fill:#007165;}
</style>
<path class="st0" d="m558.68 69.77c2.45-2.8 5.82-5.98 10.89-6.67 3.77-0.52 7.15 0.04 9.97 2.66 8.02 7.42 16.31 14.57 23.95 22.37 17.3 17.66 33.04 36.73 48.18 56.28 14.36 18.54 27.69 37.85 40.26 57.7 3.72 5.88 7.51 11.72 11.2 17.62 3.4 5.44 6.75 10.91 10.04 16.41 3.31 5.52 6.52 11.1 9.77 16.66 3 5.12 6.12 10.17 8.96 15.38 4.47 8.2 8.81 16.46 13.07 24.78 3.13 6.12 6.07 12.34 9.05 18.54 3.75 7.81 7.66 15.55 11.12 23.49 3.36 7.72 6.33 15.62 9.31 23.51 2.89 7.66 5.65 15.37 8.32 23.11 0.74 2.16 0.85 4.54 1.46 6.76 1.78 6.5 4.07 12.88 5.43 19.48 1.9 9.21 3.18 18.55 4.63 27.86 0.57 3.63 0.94 7.31 1.26 10.98 0.06 0.72-0.54 1.51-0.84 2.27-0.64-0.6-1.7-1.09-1.86-1.81-1.77-7.92-2.97-16-5.16-23.78-3.17-11.23-6.68-22.38-10.69-33.32-3.75-10.23-8.06-20.27-12.64-30.14-4.69-10.1-9.82-20.01-15.11-29.8-5.29-9.8-10.81-19.47-16.58-28.98-6.61-10.9-13.43-21.68-20.49-32.28-9.59-14.43-19.33-28.76-29.31-42.91-8.46-12-17.17-23.83-26.09-35.47-9.8-12.78-19.77-25.45-30.07-37.83-9.11-10.95-18.56-21.63-28.25-32.05-9.3-9.98-19.07-19.52-28.72-29.17-3.59-3.59-7.57-6.79-11.11-10.43-3.55-3.66-3.52-5.99 0.05-11.22z"/>
<path class="st1" d="m733.08 66.49c3.63-0.83 8.23-1.42 12.74 0.99 3.36 1.8 5.76 4.23 6.51 8.01 2.13 10.72 4.65 21.37 6.26 32.17 3.64 24.45 5.19 49.13 5.97 73.85 0.74 23.44 0.2 46.9-1.28 70.34-0.44 6.95-0.8 13.9-1.28 20.84-0.44 6.4-0.94 12.79-1.5 19.18-0.57 6.41-1.24 12.81-1.87 19.22-0.58 5.9-1.01 11.82-1.77 17.71-1.2 9.26-2.53 18.5-3.96 27.73-1.05 6.79-2.33 13.55-3.56 20.32-1.55 8.52-2.93 17.08-4.79 25.54-1.81 8.22-4.04 16.36-6.26 24.5-2.15 7.9-4.45 15.76-6.83 23.59-0.66 2.18-1.98 4.18-2.79 6.33-2.37 6.31-4.27 12.82-7.04 18.95-3.87 8.57-8.32 16.89-12.61 25.27-1.67 3.27-3.53 6.47-5.42 9.63-0.37 0.62-1.33 0.91-2.02 1.35-0.17-0.86-0.74-1.88-0.45-2.56 3.22-7.45 6.99-14.7 9.78-22.28 4.03-10.95 7.73-22.04 10.91-33.25 2.97-10.48 5.37-21.14 7.46-31.82 2.13-10.93 3.79-21.96 5.26-33 1.47-11.03 2.68-22.11 3.59-33.19 1.04-12.7 1.85-25.43 2.37-38.16 0.7-17.31 1.23-34.63 1.46-51.95 0.19-14.68 0.09-29.37-0.3-44.03-0.43-16.1-1.06-32.21-2.13-48.28-0.95-14.21-2.32-28.4-4.06-42.53-1.66-13.54-3.98-27-6.13-40.47-0.8-5.02-2.15-9.95-2.87-14.97-0.75-5.03 0.65-6.89 6.61-9.03z"/>
<g class="st2">
<path class="st3" d="m433.01 108.31c0.53-3.63 1.63-8.06 5.53-11.36 2.9-2.45 6.05-3.8 9.87-3.16 10.83 1.82 21.75 3.27 32.47 5.61 24.27 5.29 48.01 12.58 71.5 20.6 22.28 7.6 44.11 16.38 65.59 26.02 6.36 2.86 12.76 5.65 19.11 8.54 5.85 2.66 11.67 5.38 17.47 8.16 5.82 2.78 11.59 5.67 17.37 8.51 5.33 2.62 10.74 5.11 15.99 7.88 8.26 4.37 16.46 8.86 24.61 13.43 6 3.37 11.89 6.93 17.8 10.44 7.45 4.43 14.98 8.73 22.26 13.43 7.07 4.57 13.91 9.5 20.75 14.41 6.64 4.77 13.19 9.65 19.69 14.61 1.81 1.38 3.21 3.3 4.94 4.8 5.07 4.41 10.5 8.45 15.26 13.17 6.65 6.58 12.85 13.61 19.18 20.51 2.47 2.7 4.8 5.53 7.08 8.39 0.45 0.56 0.37 1.54 0.54 2.33-0.87-0.15-2.03 0.01-2.56-0.49-5.83-5.59-11.28-11.61-17.4-16.86-8.83-7.57-17.91-14.89-27.28-21.77-8.77-6.43-17.91-12.4-27.19-18.09-9.5-5.82-19.26-11.24-29.09-16.49s-19.79-10.27-29.87-15.03c-11.55-5.45-23.21-10.68-34.98-15.65-16-6.76-32.08-13.36-48.26-19.69-13.71-5.36-27.54-10.45-41.46-15.27-15.28-5.29-30.63-10.4-46.1-15.09-13.69-4.15-27.51-7.9-41.4-11.29-13.32-3.25-26.79-5.88-40.21-8.66-5-1.04-10.11-1.54-15.1-2.65-5.01-1.11-6.26-3.06-6.11-9.29z"/>
</g>
<path class="st4" d="m823.28 220.35c3.56 1.08 7.85 2.85 10.57 7.18 2.02 3.23 2.9 6.53 1.68 10.18-3.46 10.36-6.56 20.86-10.53 31.04-8.97 23.03-19.87 45.23-31.45 67.08-10.99 20.72-23.09 40.82-36.01 60.44-3.83 5.81-7.59 11.67-11.45 17.46-3.56 5.34-7.16 10.64-10.82 15.91-3.67 5.29-7.43 10.51-11.16 15.76-3.43 4.84-6.75 9.76-10.32 14.49-5.63 7.45-11.37 14.81-17.2 22.11-4.28 5.37-8.74 10.61-13.17 15.88-5.57 6.63-11.02 13.38-16.83 19.8-5.65 6.24-11.63 12.2-17.59 18.17-5.78 5.79-11.68 11.47-17.64 17.09-1.66 1.57-3.79 2.64-5.56 4.11-5.19 4.3-10.07 9.01-15.52 12.96-7.61 5.52-15.6 10.53-23.48 15.69-3.08 2.01-6.27 3.87-9.49 5.67-0.63 0.35-1.6 0.13-2.42 0.17 0.28-0.83 0.29-2 0.88-2.44 6.49-4.87 13.36-9.29 19.55-14.5 8.93-7.51 17.65-15.3 25.96-23.46 7.78-7.63 15.15-15.69 22.26-23.93 7.28-8.44 14.19-17.19 20.94-26.04s13.3-17.87 19.59-27.04c7.21-10.51 14.22-21.16 20.99-31.96 9.2-14.68 18.25-29.46 27.04-44.38 7.45-12.65 14.65-25.45 21.58-38.38 7.61-14.2 15.06-28.5 22.1-42.98 6.23-12.81 12.07-25.81 17.57-38.94 5.27-12.58 9.94-25.41 14.76-38.18 1.79-4.75 3.07-9.7 4.93-14.42 1.87-4.72 4.01-5.65 10.24-4.54z"/>
<g class="st5">
<path class="st6" d="m852.54 369.84c1.86 3.22 3.78 7.45 2.79 12.47-0.73 3.74-2.35 6.75-5.74 8.58-9.62 5.18-19.06 10.72-28.92 15.43-22.3 10.66-45.44 19.39-68.84 27.39-22.19 7.59-44.77 13.96-67.62 19.43-6.77 1.62-13.52 3.31-20.3 4.9-6.24 1.46-12.5 2.86-18.77 4.19-6.29 1.34-12.61 2.58-18.92 3.86-5.81 1.18-11.6 2.5-17.45 3.5-9.2 1.58-18.43 3.02-27.67 4.36-6.8 0.99-13.64 1.75-20.47 2.57-8.6 1.02-17.19 2.22-25.83 2.92-8.39 0.68-16.83 0.94-25.26 1.21-8.18 0.26-16.37 0.37-24.56 0.4-2.28 0.01-4.57-0.67-6.87-0.81-6.73-0.42-13.51-0.32-20.19-1.17-9.32-1.18-18.58-2.99-27.86-4.63-3.62-0.64-7.22-1.47-10.79-2.36-0.7-0.17-1.26-1-1.88-1.53 0.77-0.41 1.58-1.26 2.31-1.18 8.06 0.89 16.1 2.36 24.17 2.81 11.65 0.64 23.34 0.92 34.98 0.66 10.89-0.24 21.79-1.07 32.61-2.22 11.08-1.17 22.11-2.83 33.09-4.66s21.92-3.93 32.78-6.31c12.45-2.73 24.86-5.7 37.17-8.94 16.75-4.41 33.47-8.99 50.09-13.86 14.09-4.12 28.1-8.54 42-13.22 15.27-5.14 30.48-10.47 45.52-16.22 13.31-5.08 26.47-10.56 39.46-16.37 12.45-5.57 24.64-11.73 36.89-17.74 4.56-2.24 8.88-4.97 13.47-7.14 4.62-2.18 6.82-1.39 10.61 3.68z"/>
</g>
<circle class="st6" cx="809.09" cy="136.91" r="15.09"/>
<circle class="st3" cx="654.73" cy="35.79" r="15.09"/>
<circle class="st3" cx="486.18" cy="530.81" r="15.09"/>
<circle class="st3" cx="766.76" cy="496.13" r="15.09"/>
<circle class="st4" cx="624.54" cy="500.63" r="15.09"/>
<circle class="st4" cx="501.28" cy="50.88" r="15.09"/>
<circle class="st0" cx="858.6" cy="330.29" r="15.09"/>
<path class="st3" d="m56.96 240.33h67.34c40.02 0 64.9 22.69 64.9 57.1v0.49c0 38.31-30.74 58.32-68.32 58.32h-33.91v54.9h-30.01v-170.81zm64.91 88.82c22.69 0 36.84-12.69 36.84-30.5v-0.49c0-20.01-14.4-30.5-36.84-30.5h-34.9v61.49h34.9z"/>
<path class="st3" d="m219.95 240.33h30.01v143.47h89.79v27.33h-119.8v-170.8z"/>
<path class="st3" d="m352.69 326.22v-0.49c0-48.07 37.09-88.33 89.55-88.33s89.06 39.77 89.06 87.84v0.49c0 48.07-37.09 88.33-89.55 88.33s-89.06-39.77-89.06-87.84zm147.13 0v-0.49c0-33.18-24.16-60.51-58.07-60.51s-57.58 26.84-57.58 60.02v0.49c0 33.18 24.16 60.51 58.07 60.51 33.91 0.01 57.58-26.83 57.58-60.02z"/>
  <path class="st3" d="m554.96 386.25 18.06-21.47c16.35 14.15 32.94 22.2 53.92 22.2 18.54 0 30.26-8.78 30.26-21.47v-0.49c0-12.2-6.83-18.79-38.55-26.11-36.36-8.78-56.85-19.52-56.85-51v-0.49c0-29.28 24.4-49.53 58.32-49.53 24.89 0 44.65 7.56 61.98 21.47l-16.1 22.69c-15.37-11.47-30.74-17.57-46.36-17.57-17.57 0-27.82 9.03-27.82 20.25v0.49c0 13.18 7.81 19.03 40.75 26.84 36.11 8.78 54.66 21.72 54.66 50.02v0.49c0 31.96-25.13 51-61 51-26.13 0.01-50.77-9.02-71.27-27.32z"/>
</svg>"},905:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(413)),i=u(n(141));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,r=e.title,u=e.code,s=e.children,f=e.alwaysOn,d=void 0!==f&&f,p=(t=(0,a.useState)(!1),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),y=p[0],h=p[1],g=d?a.default.createElement("div",{className:o.default.alwaysOnMessage},"Always On"):a.default.createElement(i.default,{onClick:function(e){return function(e,t){"INPUT"===t.target.tagName&&l.default.customize(e,t.target.checked)}(u,e)},defaultChecked:l.default.hasConsented(u)}),m=function(){h(!y)};return a.default.createElement("div",{className:o.default.cookieType},a.default.createElement("div",{className:o.default.switchContainer},a.default.createElement("div",{role:"button",className:o.default.toggleExplanation,onClick:m,onKeyDown:m,tabIndex:0,"aria-label":"Toggle explanation of ".concat(r," Cookies.")},a.default.createElement("span",{className:o.default.toggleIcon},y?"-":"+"),a.default.createElement("strong",{className:o.default.toggleTitle},r)),a.default.createElement("div",{className:o.default.spacer}),g),!!y&&a.default.createElement("div",{className:o.default.explanationContainer},a.default.createElement("div",{className:o.default.toggleIcon}," "),s))}},628:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=s(n(294)),a=n(357),l=s(n(177)),o=s(n(905)),i=s(n(810)),u=s(n(980));function s(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.close,n=e.show;return r.default.createElement(a.CSSTransition,{in:n,timeout:200,classNames:{enter:i.default.slideOutEnter,enterActive:i.default.slideOutEnterActive,exit:i.default.slideOutExit,exitActive:i.default.slideOutExitActive},unmountOnExit:!0},r.default.createElement("div",{className:i.default.slideOut},r.default.createElement("div",{className:i.default.plosLogoWrapper},r.default.createElement("div",null,r.default.createElement("img",{alt:"PLOS Logo",className:i.default.plosLogo,src:u.default})),r.default.createElement("h3",{className:i.default.heading},"Cookie Preference Center")),r.default.createElement("p",{className:i.default.text},"Our website uses different types of cookies. Optional cookies will only be set with your consent and you may withdraw this consent at any time. Below you can learn more about the types of cookies PLOS uses and register your cookie preferences."),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.accept(),t()}},"Accept All Cookies")),r.default.createElement("div",null,r.default.createElement("h3",{className:i.default.customizeHeading},"Customize Your Cookie Preference"),r.default.createElement(o.default,{title:"Strictly Necessary",alwaysOn:!0},"These cookies are necessary to operating the PLOS website. They provide site security, help balance load on our servers, and other essential functions."),r.default.createElement(o.default,{title:"Functional",code:"functionality"},"These cookies and other technologies provide useful site functionality such as remembering your site preferences, allowing you to navigate the PLOS site more efficiently."),r.default.createElement(o.default,{title:"Performance and Analytics",code:"analytics"},"These cookies and other technologies analyze how the PLOS website is accessed, used, and performing in order to maintain and continually improve user experience on the site."),r.default.createElement(o.default,{title:"Marketing",code:"advertising"},"These cookies deliver contextual advertisements on the PLOS site and help third-parties serve you targeted advertisements based on your browsing history.")),r.default.createElement("div",{className:i.default.spacer}),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.hasInteracted()||l.default.reject(),t()}},"Save Selected Preferences and Close")),r.default.createElement("a",{className:i.default.underline,href:"https://plos.org/cookies-policy",target:"_blank",rel:"noreferrer"},"For more information about the cookies and other technologies used by us, please read our Cookie Policy.")))}},141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=o(n(403)),l=o(n(454));function o(e){return e&&e.__esModule?e:{default:e}}function i(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,o=e.defaultChecked,u=e.onClick,s=e.disabled,c=void 0!==s&&s,f="switch"+(t=r.default.useState((0,a.default)()),n=1,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return i(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?i(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}())[0];return r.default.createElement("div",{className:l.default.switch},r.default.createElement("input",{className:l.default.input,disabled:c,id:f,type:"checkbox",defaultChecked:o,onChange:u}),r.default.createElement("label",{className:l.default.paddle,htmlFor:f},r.default.createElement("span",{className:l.default.active},"On"),r.default.createElement("span",{className:l.default.inactive},"Off")))}},403:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var n=0;t.default=function(){return n++}},773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(808))&&r.__esModule?r:{default:r},l=n(773);function o(e){return Object.assign({},...l.VALID_PURPOSES.map((t=>({[t]:e}))))}var i={get:function(){try{const e=JSON.parse(a.default.get(l.COOKIE_KEY));return e?!0===e?o(!0):e:o(!1)}catch(e){return o(!1)}},isSet:function(){return void 0!==a.default.get(l.COOKIE_KEY)},remove:function(){a.default.remove(l.COOKIE_KEY)},set:function(e){const t=window.location.hostname;a.default.set(l.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:l.RECONSENT_INTERVAL})}};t.default=i},177:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(502))&&r.__esModule?r:{default:r},l=n(773);function o(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,a.default.get())}var i={accept:function(){a.default.set(!0),o()},customize:function(e,t){a.default.set(Object.assign(a.default.get(),{[e]:t})),o()},hasConsented:function(e){if(!l.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+l.VALID_PURPOSES.toString());return a.default.get()[e]},hasInteracted:function(){return a.default.isSet()},reject:function(){a.default.set(!1),o()},reset:function(){a.default.remove()},VALID_PURPOSES:l.VALID_PURPOSES};t.default=i},151:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._2w1UwhvJHT_qwQKK4m2Mtf{background-color:#333;bottom:0;left:0;position:fixed;right:0;opacity:.5;top:0;z-index:1}._1y82vgULYYDGyWdjHVia6r{opacity:0}._367_oaFBsPkUkmVR1bGNYm{opacity:.5;transition:opacity 200ms}._2dI2_nwyJPeiTPjhARwALQ{opacity:.5}._2f5ts8uYo0Bpq4XYl7aiJU{opacity:0;transition:opacity 200ms}",""]),a.locals={overlay:"_2w1UwhvJHT_qwQKK4m2Mtf",fadeInEnter:"_1y82vgULYYDGyWdjHVia6r",fadeInEnterActive:"_367_oaFBsPkUkmVR1bGNYm",fadeInExit:"_2dI2_nwyJPeiTPjhARwALQ",fadeInExitActive:"_2f5ts8uYo0Bpq4XYl7aiJU"};const l=a},148:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._3A__ku4NC-f73WZK-2WSLx{flex-grow:1}._2CmoA8p3s0vKIspSCosl9G{cursor:pointer;display:flex;font-weight:bold}._3UCm4aXUK13m4R_iCXSEyn{display:inline-block;flex:0 0 1em}._2qXwuhqwMHjam4FPIz7LCs{flex-shrink:0}.l1QQ8S-nhYCUogSWaE0yF,.s4KCa9TCuz7L8vB3Y0Zto{align-items:center;display:flex;margin-bottom:4px;min-height:32px}._1FFdDFwCKdHcKsmbvSZf6_{margin-right:2px;font-style:italic}",""]),a.locals={spacer:"_3A__ku4NC-f73WZK-2WSLx",toggleExplanation:"_2CmoA8p3s0vKIspSCosl9G",toggleIcon:"_3UCm4aXUK13m4R_iCXSEyn",toggleTitle:"_2qXwuhqwMHjam4FPIz7LCs",switchContainer:"l1QQ8S-nhYCUogSWaE0yF",explanationContainer:"s4KCa9TCuz7L8vB3Y0Zto",alwaysOnMessage:"_1FFdDFwCKdHcKsmbvSZf6_"};const l=a},908:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._1tEo1q2cUK9NIysoJrVPWB{background-color:#fff;bottom:0;color:#1c2e5e;display:flex;flex-direction:column;font-size:14px;max-height:100%;max-width:95%;min-width:320px;padding:16px;position:fixed;overflow-y:auto;top:0;width:25%;z-index:2}.T1Y5lu3DhJYBpNej0XUqn{left:-100vw}._1LboXNkeCnS8lrcYjApaZG{left:0;transition:left 200ms}.M0lj2upZTiu02JJDGvGB{left:0}._3MASX-v6vhk8saSO9VmJ6U{left:-100vw;transition:left 200ms}._28VwqbFjT3AsGRoYLhfgjy{color:#1c2e5e;font-size:20px;font-weight:bold}.xI7u62vIvKFhmZX2xirm- ._28VwqbFjT3AsGRoYLhfgjy{margin-bottom:0}._1rHZW01Wf74DBd08dYWESO{height:40px;margin-right:5px;width:auto}.xI7u62vIvKFhmZX2xirm-{align-items:center;display:flex;flex-direction:row}._369CBb-mfyjgJZcxE85upM{font-size:14px}._1u4ynVnXwZaZEsjTHxtV0v{flex-grow:1}._29PzLWpueUEyRToV1hjZjn{display:flex;flex-wrap:wrap;justify-content:space-around;margin-top:16px;margin-bottom:24px}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn{flex-direction:column}}._29PzLWpueUEyRToV1hjZjn button{background-color:#1c2e5e;border:1px solid #000;border-radius:5px;color:#fff;cursor:pointer;font-size:14px;font-weight:bold;flex-grow:1;padding:8px;white-space:nowrap}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn button~button{margin-top:12px}}@media(min-width: 1501px){._29PzLWpueUEyRToV1hjZjn button~button{margin-left:12px}}.ITkiffnwKKM34XaIHLjB_{color:#1c2e5e;font-size:14px;font-weight:bold}._38RYPxeKGNUF74SufFb2Cn{text-decoration:underline;text-decoration-color:blue}",""]),a.locals={slideOut:"_1tEo1q2cUK9NIysoJrVPWB",slideOutEnter:"T1Y5lu3DhJYBpNej0XUqn",slideOutEnterActive:"_1LboXNkeCnS8lrcYjApaZG",slideOutExit:"M0lj2upZTiu02JJDGvGB",slideOutExitActive:"_3MASX-v6vhk8saSO9VmJ6U",heading:"_28VwqbFjT3AsGRoYLhfgjy",plosLogoWrapper:"xI7u62vIvKFhmZX2xirm-",plosLogo:"_1rHZW01Wf74DBd08dYWESO",text:"_369CBb-mfyjgJZcxE85upM",spacer:"_1u4ynVnXwZaZEsjTHxtV0v",buttonContainer:"_29PzLWpueUEyRToV1hjZjn",customizeHeading:"ITkiffnwKKM34XaIHLjB_",underline:"_38RYPxeKGNUF74SufFb2Cn"};const l=a},174:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,'._2ynah8Lgqwdr9aOADyNLnm{color:#fefefe;font-size:12px;font-weight:bold;height:32px;outline:0;position:relative;user-select:none}._16DjzBVfVPFmQVgTgNlqAD{margin-bottom:0;opacity:0;position:absolute}._2o1hzYk15DlFY9KaHai3O2{background:#cacaca;border-radius:16px;color:inherit;cursor:pointer;display:block;font-weight:inherit;height:32px;position:relative;transition:all .25s ease-out;width:64px}._2o1hzYk15DlFY9KaHai3O2::after{background:#fefefe;border-radius:14px;content:"";display:block;height:24px;left:4px;position:absolute;transform:translate3d(0, 0, 0);transition:all .25s ease-out;top:4px;width:24px}input:checked~._2o1hzYk15DlFY9KaHai3O2::after{left:36px}input:checked~._2o1hzYk15DlFY9KaHai3O2{background:#32a960}._3vFoGG1De0BqwBpqyyWHgM{display:none;left:10%}input:checked+label>._3vFoGG1De0BqwBpqyyWHgM{display:block}._3vFoGG1De0BqwBpqyyWHgM,.KUzu_RflxRcodvteC94f5{position:absolute;transform:translateY(-50%);top:50%}.KUzu_RflxRcodvteC94f5{right:15%}input:checked+label>.KUzu_RflxRcodvteC94f5{display:none}',""]),a.locals={switch:"_2ynah8Lgqwdr9aOADyNLnm",input:"_16DjzBVfVPFmQVgTgNlqAD",paddle:"_2o1hzYk15DlFY9KaHai3O2",active:"_3vFoGG1De0BqwBpqyyWHgM",inactive:"KUzu_RflxRcodvteC94f5"};const l=a},645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n=e(t);return t[2]?"@media ".concat(t[2]," {").concat(n,"}"):n})).join("")},t.i=function(e,n,r){"string"==typeof e&&(e=[[null,e,""]]);var a={};if(r)for(var l=0;l<this.length;l++){var o=this[l][0];null!=o&&(a[o]=!0)}for(var i=0;i<e.length;i++){var u=[].concat(e[i]);r&&a[u[0]]||(n&&(u[2]?u[2]="".concat(n," and ").concat(u[2]):u[2]=n),t.push(u))}},t}},808:(e,t,n)=>{var r,a,l;void 0===(a="function"==typeof(r=l=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var r in n)t[r]=n[r]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(r){function a(){}function l(t,n,l){if("undefined"!=typeof document){"number"==typeof(l=e({path:"/"},a.defaults,l)).expires&&(l.expires=new Date(1*new Date+864e5*l.expires)),l.expires=l.expires?l.expires.toUTCString():"";try{var o=JSON.stringify(n);/^[\{\[]/.test(o)&&(n=o)}catch(e){}n=r.write?r.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var i="";for(var u in l)l[u]&&(i+="; "+u,!0!==l[u]&&(i+="="+l[u].split(";")[0]));return document.cookie=t+"="+n+i}}function o(e,n){if("undefined"!=typeof document){for(var a={},l=document.cookie?document.cookie.split("; "):[],o=0;o<l.length;o++){var i=l[o].split("="),u=i.slice(1).join("=");n||'"'!==u.charAt(0)||(u=u.slice(1,-1));try{var s=t(i[0]);if(u=(r.read||r)(u,s)||t(u),n)try{u=JSON.parse(u)}catch(e){}if(a[s]=u,e===s)break}catch(e){}}return e?a[e]:a}}return a.set=l,a.get=function(e){return o(e,!1)},a.getJSON=function(e){return o(e,!0)},a.remove=function(t,n){l(t,"",e(n,{expires:-1}))},a.defaults={},a.withConverter=n,a}((function(){}))})?r.call(t,n,t,e):r)||(e.exports=a),e.exports=l()},418:e=>{"use strict";var t=Object.getOwnPropertySymbols,n=Object.prototype.hasOwnProperty,r=Object.prototype.propertyIsEnumerable;function a(e){if(null==e)throw new TypeError("Object.assign cannot be called with null or undefined");return Object(e)}e.exports=function(){try{if(!Object.assign)return!1;var e=new String("abc");if(e[5]="de","5"===Object.getOwnPropertyNames(e)[0])return!1;for(var t={},n=0;n<10;n++)t["_"+String.fromCharCode(n)]=n;if("0123456789"!==Object.getOwnPropertyNames(t).map((function(e){return t[e]})).join(""))return!1;var r={};return"abcdefghijklmnopqrst".split("").forEach((function(e){r[e]=e})),"abcdefghijklmnopqrst"===Object.keys(Object.assign({},r)).join("")}catch(e){return!1}}()?Object.assign:function(e,l){for(var o,i,u=a(e),s=1;s<arguments.length;s++){for(var c in o=Object(arguments[s]))n.call(o,c)&&(u[c]=o[c]);if(t){i=t(o);for(var f=0;f<i.length;f++)r.call(o,i[f])&&(u[i[f]]=o[i[f]])}}return u}},448:(e,t,n)=>{"use strict";var r=n(294),a=n(418),l=n(840);function o(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}if(!r)throw Error(o(227));var i=new Set,u={};function s(e,t){c(e,t),c(e+"Capture",t)}function c(e,t){for(u[e]=t,e=0;e<t.length;e++)i.add(t[e])}var f=!("undefined"==typeof window||void 0===window.document||void 0===window.document.createElement),d=/^[:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD][:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD\-.0-9\u00B7\u0300-\u036F\u203F-\u2040]*$/,p=Object.prototype.hasOwnProperty,y={},h={};function g(e,t,n,r,a,l,o){this.acceptsBooleans=2===t||3===t||4===t,this.attributeName=r,this.attributeNamespace=a,this.mustUseProperty=n,this.propertyName=e,this.type=t,this.sanitizeURL=l,this.removeEmptyString=o}var m={};"children dangerouslySetInnerHTML defaultValue defaultChecked innerHTML suppressContentEditableWarning suppressHydrationWarning style".split(" ").forEach((function(e){m[e]=new g(e,0,!1,e,null,!1,!1)})),[["acceptCharset","accept-charset"],["className","class"],["htmlFor","for"],["httpEquiv","http-equiv"]].forEach((function(e){var t=e[0];m[t]=new g(t,1,!1,e[1],null,!1,!1)})),["contentEditable","draggable","spellCheck","value"].forEach((function(e){m[e]=new g(e,2,!1,e.toLowerCase(),null,!1,!1)})),["autoReverse","externalResourcesRequired","focusable","preserveAlpha"].forEach((function(e){m[e]=new g(e,2,!1,e,null,!1,!1)})),"allowFullScreen async autoFocus autoPlay controls default defer disabled disablePictureInPicture disableRemotePlayback formNoValidate hidden loop noModule noValidate open playsInline readOnly required reversed scoped seamless itemScope".split(" ").forEach((function(e){m[e]=new g(e,3,!1,e.toLowerCase(),null,!1,!1)})),["checked","multiple","muted","selected"].forEach((function(e){m[e]=new g(e,3,!0,e,null,!1,!1)})),["capture","download"].forEach((function(e){m[e]=new g(e,4,!1,e,null,!1,!1)})),["cols","rows","size","span"].forEach((function(e){m[e]=new g(e,6,!1,e,null,!1,!1)})),["rowSpan","start"].forEach((function(e){m[e]=new g(e,5,!1,e.toLowerCase(),null,!1,!1)}));var v=/[\-:]([a-z])/g;function b(e){return e[1].toUpperCase()}function M(e,t,n,r){var a=m.hasOwnProperty(t)?m[t]:null;(null!==a?0===a.type:!r&&2<t.length&&("o"===t[0]||"O"===t[0])&&("n"===t[1]||"N"===t[1]))||(function(e,t,n,r){if(null==t||function(e,t,n,r){if(null!==n&&0===n.type)return!1;switch(typeof t){case"function":case"symbol":return!0;case"boolean":return!r&&(null!==n?!n.acceptsBooleans:"data-"!==(e=e.toLowerCase().slice(0,5))&&"aria-"!==e);default:return!1}}(e,t,n,r))return!0;if(r)return!1;if(null!==n)switch(n.type){case 3:return!t;case 4:return!1===t;case 5:return isNaN(t);case 6:return isNaN(t)||1>t}return!1}(t,n,a,r)&&(n=null),r||null===a?function(e){return!!p.call(h,e)||!p.call(y,e)&&(d.test(e)?h[e]=!0:(y[e]=!0,!1))}(t)&&(null===n?e.removeAttribute(t):e.setAttribute(t,""+n)):a.mustUseProperty?e[a.propertyName]=null===n?3!==a.type&&"":n:(t=a.attributeName,r=a.attributeNamespace,null===n?e.removeAttribute(t):(n=3===(a=a.type)||4===a&&!0===n?"":""+n,r?e.setAttributeNS(r,t,n):e.setAttribute(t,n))))}"accent-height alignment-baseline arabic-form baseline-shift cap-height clip-path clip-rule color-interpolation color-interpolation-filters color-profile color-rendering dominant-baseline enable-background fill-opacity fill-rule flood-color flood-opacity font-family font-size font-size-adjust font-stretch font-style font-variant font-weight glyph-name glyph-orientation-horizontal glyph-orientation-vertical horiz-adv-x horiz-origin-x image-rendering letter-spacing lighting-color marker-end marker-mid marker-start overline-position overline-thickness paint-order panose-1 pointer-events rendering-intent shape-rendering stop-color stop-opacity strikethrough-position strikethrough-thickness stroke-dasharray stroke-dashoffset stroke-linecap stroke-linejoin stroke-miterlimit stroke-opacity stroke-width text-anchor text-decoration text-rendering underline-position underline-thickness unicode-bidi unicode-range units-per-em v-alphabetic v-hanging v-ideographic v-mathematical vector-effect vert-adv-y vert-origin-x vert-origin-y word-spacing writing-mode xmlns:xlink x-height".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,null,!1,!1)})),"xlink:actuate xlink:arcrole xlink:role xlink:show xlink:title xlink:type".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/1999/xlink",!1,!1)})),["xml:base","xml:lang","xml:space"].forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/XML/1998/namespace",!1,!1)})),["tabIndex","crossOrigin"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!1,!1)})),m.xlinkHref=new g("xlinkHref",1,!1,"xlink:href","http://www.w3.org/1999/xlink",!0,!1),["src","href","action","formAction"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!0,!0)}));var E=r.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED,L=60103,N=60106,w=60107,S=60108,x=60114,k=60109,j=60110,T=60112,C=60113,I=60120,D=60115,O=60116,z=60121,A=60128,_=60129,P=60130,U=60131;if("function"==typeof Symbol&&Symbol.for){var Y=Symbol.for;L=Y("react.element"),N=Y("react.portal"),w=Y("react.fragment"),S=Y("react.strict_mode"),x=Y("react.profiler"),k=Y("react.provider"),j=Y("react.context"),T=Y("react.forward_ref"),C=Y("react.suspense"),I=Y("react.suspense_list"),D=Y("react.memo"),O=Y("react.lazy"),z=Y("react.block"),Y("react.scope"),A=Y("react.opaque.id"),_=Y("react.debug_trace_mode"),P=Y("react.offscreen"),U=Y("react.legacy_hidden")}var Q,R="function"==typeof Symbol&&Symbol.iterator;function F(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=R&&e[R]||e["@iterator"])?e:null}function V(e){if(void 0===Q)try{throw Error()}catch(e){var t=e.stack.trim().match(/\n( *(at )?)/);Q=t&&t[1]||""}return"\n"+Q+e}var B=!1;function W(e,t){if(!e||B)return"";B=!0;var n=Error.prepareStackTrace;Error.prepareStackTrace=void 0;try{if(t)if(t=function(){throw Error()},Object.defineProperty(t.prototype,"props",{set:function(){throw Error()}}),"object"==typeof Reflect&&Reflect.construct){try{Reflect.construct(t,[])}catch(e){var r=e}Reflect.construct(e,[],t)}else{try{t.call()}catch(e){r=e}e.call(t.prototype)}else{try{throw Error()}catch(e){r=e}e()}}catch(e){if(e&&r&&"string"==typeof e.stack){for(var a=e.stack.split("\n"),l=r.stack.split("\n"),o=a.length-1,i=l.length-1;1<=o&&0<=i&&a[o]!==l[i];)i--;for(;1<=o&&0<=i;o--,i--)if(a[o]!==l[i]){if(1!==o||1!==i)do{if(o--,0>--i||a[o]!==l[i])return"\n"+a[o].replace(" at new "," at ")}while(1<=o&&0<=i);break}}}finally{B=!1,Error.prepareStackTrace=n}return(e=e?e.displayName||e.name:"")?V(e):""}function H(e){switch(e.tag){case 5:return V(e.type);case 16:return V("Lazy");case 13:return V("Suspense");case 19:return V("SuspenseList");case 0:case 2:case 15:return W(e.type,!1);case 11:return W(e.type.render,!1);case 22:return W(e.type._render,!1);case 1:return W(e.type,!0);default:return""}}function K(e){if(null==e)return null;if("function"==typeof e)return e.displayName||e.name||null;if("string"==typeof e)return e;switch(e){case w:return"Fragment";case N:return"Portal";case x:return"Profiler";case S:return"StrictMode";case C:return"Suspense";case I:return"SuspenseList"}if("object"==typeof e)switch(e.$$typeof){case j:return(e.displayName||"Context")+".Consumer";case k:return(e._context.displayName||"Context")+".Provider";case T:var t=e.render;return t=t.displayName||t.name||"",e.displayName||(""!==t?"ForwardRef("+t+")":"ForwardRef");case D:return K(e.type);case z:return K(e._render);case O:t=e._payload,e=e._init;try{return K(e(t))}catch(e){}}return null}function G(e){switch(typeof e){case"boolean":case"number":case"object":case"string":case"undefined":return e;default:return""}}function $(e){var t=e.type;return(e=e.nodeName)&&"input"===e.toLowerCase()&&("checkbox"===t||"radio"===t)}function q(e){e._valueTracker||(e._valueTracker=function(e){var t=$(e)?"checked":"value",n=Object.getOwnPropertyDescriptor(e.constructor.prototype,t),r=""+e[t];if(!e.hasOwnProperty(t)&&void 0!==n&&"function"==typeof n.get&&"function"==typeof n.set){var a=n.get,l=n.set;return Object.defineProperty(e,t,{configurable:!0,get:function(){return a.call(this)},set:function(e){r=""+e,l.call(this,e)}}),Object.defineProperty(e,t,{enumerable:n.enumerable}),{getValue:function(){return r},setValue:function(e){r=""+e},stopTracking:function(){e._valueTracker=null,delete e[t]}}}}(e))}function Z(e){if(!e)return!1;var t=e._valueTracker;if(!t)return!0;var n=t.getValue(),r="";return e&&(r=$(e)?e.checked?"true":"false":e.value),(e=r)!==n&&(t.setValue(e),!0)}function X(e){if(void 0===(e=e||("undefined"!=typeof document?document:void 0)))return null;try{return e.activeElement||e.body}catch(t){return e.body}}function J(e,t){var n=t.checked;return a({},t,{defaultChecked:void 0,defaultValue:void 0,value:void 0,checked:null!=n?n:e._wrapperState.initialChecked})}function ee(e,t){var n=null==t.defaultValue?"":t.defaultValue,r=null!=t.checked?t.checked:t.defaultChecked;n=G(null!=t.value?t.value:n),e._wrapperState={initialChecked:r,initialValue:n,controlled:"checkbox"===t.type||"radio"===t.type?null!=t.checked:null!=t.value}}function te(e,t){null!=(t=t.checked)&&M(e,"checked",t,!1)}function ne(e,t){te(e,t);var n=G(t.value),r=t.type;if(null!=n)"number"===r?(0===n&&""===e.value||e.value!=n)&&(e.value=""+n):e.value!==""+n&&(e.value=""+n);else if("submit"===r||"reset"===r)return void e.removeAttribute("value");t.hasOwnProperty("value")?ae(e,t.type,n):t.hasOwnProperty("defaultValue")&&ae(e,t.type,G(t.defaultValue)),null==t.checked&&null!=t.defaultChecked&&(e.defaultChecked=!!t.defaultChecked)}function re(e,t,n){if(t.hasOwnProperty("value")||t.hasOwnProperty("defaultValue")){var r=t.type;if(!("submit"!==r&&"reset"!==r||void 0!==t.value&&null!==t.value))return;t=""+e._wrapperState.initialValue,n||t===e.value||(e.value=t),e.defaultValue=t}""!==(n=e.name)&&(e.name=""),e.defaultChecked=!!e._wrapperState.initialChecked,""!==n&&(e.name=n)}function ae(e,t,n){"number"===t&&X(e.ownerDocument)===e||(null==n?e.defaultValue=""+e._wrapperState.initialValue:e.defaultValue!==""+n&&(e.defaultValue=""+n))}function le(e,t){return e=a({children:void 0},t),(t=function(e){var t="";return r.Children.forEach(e,(function(e){null!=e&&(t+=e)})),t}(t.children))&&(e.children=t),e}function oe(e,t,n,r){if(e=e.options,t){t={};for(var a=0;a<n.length;a++)t["$"+n[a]]=!0;for(n=0;n<e.length;n++)a=t.hasOwnProperty("$"+e[n].value),e[n].selected!==a&&(e[n].selected=a),a&&r&&(e[n].defaultSelected=!0)}else{for(n=""+G(n),t=null,a=0;a<e.length;a++){if(e[a].value===n)return e[a].selected=!0,void(r&&(e[a].defaultSelected=!0));null!==t||e[a].disabled||(t=e[a])}null!==t&&(t.selected=!0)}}function ie(e,t){if(null!=t.dangerouslySetInnerHTML)throw Error(o(91));return a({},t,{value:void 0,defaultValue:void 0,children:""+e._wrapperState.initialValue})}function ue(e,t){var n=t.value;if(null==n){if(n=t.children,t=t.defaultValue,null!=n){if(null!=t)throw Error(o(92));if(Array.isArray(n)){if(!(1>=n.length))throw Error(o(93));n=n[0]}t=n}null==t&&(t=""),n=t}e._wrapperState={initialValue:G(n)}}function se(e,t){var n=G(t.value),r=G(t.defaultValue);null!=n&&((n=""+n)!==e.value&&(e.value=n),null==t.defaultValue&&e.defaultValue!==n&&(e.defaultValue=n)),null!=r&&(e.defaultValue=""+r)}function ce(e){var t=e.textContent;t===e._wrapperState.initialValue&&""!==t&&null!==t&&(e.value=t)}var fe="http://www.w3.org/1999/xhtml";function de(e){switch(e){case"svg":return"http://www.w3.org/2000/svg";case"math":return"http://www.w3.org/1998/Math/MathML";default:return"http://www.w3.org/1999/xhtml"}}function pe(e,t){return null==e||"http://www.w3.org/1999/xhtml"===e?de(t):"http://www.w3.org/2000/svg"===e&&"foreignObject"===t?"http://www.w3.org/1999/xhtml":e}var ye,he,ge=(he=function(e,t){if("http://www.w3.org/2000/svg"!==e.namespaceURI||"innerHTML"in e)e.innerHTML=t;else{for((ye=ye||document.createElement("div")).innerHTML="<svg>"+t.valueOf().toString()+"</svg>",t=ye.firstChild;e.firstChild;)e.removeChild(e.firstChild);for(;t.firstChild;)e.appendChild(t.firstChild)}},"undefined"!=typeof MSApp&&MSApp.execUnsafeLocalFunction?function(e,t,n,r){MSApp.execUnsafeLocalFunction((function(){return he(e,t)}))}:he);function me(e,t){if(t){var n=e.firstChild;if(n&&n===e.lastChild&&3===n.nodeType)return void(n.nodeValue=t)}e.textContent=t}var ve={animationIterationCount:!0,borderImageOutset:!0,borderImageSlice:!0,borderImageWidth:!0,boxFlex:!0,boxFlexGroup:!0,boxOrdinalGroup:!0,columnCount:!0,columns:!0,flex:!0,flexGrow:!0,flexPositive:!0,flexShrink:!0,flexNegative:!0,flexOrder:!0,gridArea:!0,gridRow:!0,gridRowEnd:!0,gridRowSpan:!0,gridRowStart:!0,gridColumn:!0,gridColumnEnd:!0,gridColumnSpan:!0,gridColumnStart:!0,fontWeight:!0,lineClamp:!0,lineHeight:!0,opacity:!0,order:!0,orphans:!0,tabSize:!0,widows:!0,zIndex:!0,zoom:!0,fillOpacity:!0,floodOpacity:!0,stopOpacity:!0,strokeDasharray:!0,strokeDashoffset:!0,strokeMiterlimit:!0,strokeOpacity:!0,strokeWidth:!0},be=["Webkit","ms","Moz","O"];function Me(e,t,n){return null==t||"boolean"==typeof t||""===t?"":n||"number"!=typeof t||0===t||ve.hasOwnProperty(e)&&ve[e]?(""+t).trim():t+"px"}function Ee(e,t){for(var n in e=e.style,t)if(t.hasOwnProperty(n)){var r=0===n.indexOf("--"),a=Me(n,t[n],r);"float"===n&&(n="cssFloat"),r?e.setProperty(n,a):e[n]=a}}Object.keys(ve).forEach((function(e){be.forEach((function(t){t=t+e.charAt(0).toUpperCase()+e.substring(1),ve[t]=ve[e]}))}));var Le=a({menuitem:!0},{area:!0,base:!0,br:!0,col:!0,embed:!0,hr:!0,img:!0,input:!0,keygen:!0,link:!0,meta:!0,param:!0,source:!0,track:!0,wbr:!0});function Ne(e,t){if(t){if(Le[e]&&(null!=t.children||null!=t.dangerouslySetInnerHTML))throw Error(o(137,e));if(null!=t.dangerouslySetInnerHTML){if(null!=t.children)throw Error(o(60));if("object"!=typeof t.dangerouslySetInnerHTML||!("__html"in t.dangerouslySetInnerHTML))throw Error(o(61))}if(null!=t.style&&"object"!=typeof t.style)throw Error(o(62))}}function we(e,t){if(-1===e.indexOf("-"))return"string"==typeof t.is;switch(e){case"annotation-xml":case"color-profile":case"font-face":case"font-face-src":case"font-face-uri":case"font-face-format":case"font-face-name":case"missing-glyph":return!1;default:return!0}}function Se(e){return(e=e.target||e.srcElement||window).correspondingUseElement&&(e=e.correspondingUseElement),3===e.nodeType?e.parentNode:e}var xe=null,ke=null,je=null;function Te(e){if(e=Jr(e)){if("function"!=typeof xe)throw Error(o(280));var t=e.stateNode;t&&(t=ta(t),xe(e.stateNode,e.type,t))}}function Ce(e){ke?je?je.push(e):je=[e]:ke=e}function Ie(){if(ke){var e=ke,t=je;if(je=ke=null,Te(e),t)for(e=0;e<t.length;e++)Te(t[e])}}function De(e,t){return e(t)}function Oe(e,t,n,r,a){return e(t,n,r,a)}function ze(){}var Ae=De,_e=!1,Pe=!1;function Ue(){null===ke&&null===je||(ze(),Ie())}function Ye(e,t){var n=e.stateNode;if(null===n)return null;var r=ta(n);if(null===r)return null;n=r[t];e:switch(t){case"onClick":case"onClickCapture":case"onDoubleClick":case"onDoubleClickCapture":case"onMouseDown":case"onMouseDownCapture":case"onMouseMove":case"onMouseMoveCapture":case"onMouseUp":case"onMouseUpCapture":case"onMouseEnter":(r=!r.disabled)||(r=!("button"===(e=e.type)||"input"===e||"select"===e||"textarea"===e)),e=!r;break e;default:e=!1}if(e)return null;if(n&&"function"!=typeof n)throw Error(o(231,t,typeof n));return n}var Qe=!1;if(f)try{var Re={};Object.defineProperty(Re,"passive",{get:function(){Qe=!0}}),window.addEventListener("test",Re,Re),window.removeEventListener("test",Re,Re)}catch(he){Qe=!1}function Fe(e,t,n,r,a,l,o,i,u){var s=Array.prototype.slice.call(arguments,3);try{t.apply(n,s)}catch(e){this.onError(e)}}var Ve=!1,Be=null,We=!1,He=null,Ke={onError:function(e){Ve=!0,Be=e}};function Ge(e,t,n,r,a,l,o,i,u){Ve=!1,Be=null,Fe.apply(Ke,arguments)}function $e(e){var t=e,n=e;if(e.alternate)for(;t.return;)t=t.return;else{e=t;do{0!=(1026&(t=e).flags)&&(n=t.return),e=t.return}while(e)}return 3===t.tag?n:null}function qe(e){if(13===e.tag){var t=e.memoizedState;if(null===t&&null!==(e=e.alternate)&&(t=e.memoizedState),null!==t)return t.dehydrated}return null}function Ze(e){if($e(e)!==e)throw Error(o(188))}function Xe(e){if(!(e=function(e){var t=e.alternate;if(!t){if(null===(t=$e(e)))throw Error(o(188));return t!==e?null:e}for(var n=e,r=t;;){var a=n.return;if(null===a)break;var l=a.alternate;if(null===l){if(null!==(r=a.return)){n=r;continue}break}if(a.child===l.child){for(l=a.child;l;){if(l===n)return Ze(a),e;if(l===r)return Ze(a),t;l=l.sibling}throw Error(o(188))}if(n.return!==r.return)n=a,r=l;else{for(var i=!1,u=a.child;u;){if(u===n){i=!0,n=a,r=l;break}if(u===r){i=!0,r=a,n=l;break}u=u.sibling}if(!i){for(u=l.child;u;){if(u===n){i=!0,n=l,r=a;break}if(u===r){i=!0,r=l,n=a;break}u=u.sibling}if(!i)throw Error(o(189))}}if(n.alternate!==r)throw Error(o(190))}if(3!==n.tag)throw Error(o(188));return n.stateNode.current===n?e:t}(e)))return null;for(var t=e;;){if(5===t.tag||6===t.tag)return t;if(t.child)t.child.return=t,t=t.child;else{if(t===e)break;for(;!t.sibling;){if(!t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}}return null}function Je(e,t){for(var n=e.alternate;null!==t;){if(t===e||t===n)return!0;t=t.return}return!1}var et,tt,nt,rt,at=!1,lt=[],ot=null,it=null,ut=null,st=new Map,ct=new Map,ft=[],dt="mousedown mouseup touchcancel touchend touchstart auxclick dblclick pointercancel pointerdown pointerup dragend dragstart drop compositionend compositionstart keydown keypress keyup input textInput copy cut paste click change contextmenu reset submit".split(" ");function pt(e,t,n,r,a){return{blockedOn:e,domEventName:t,eventSystemFlags:16|n,nativeEvent:a,targetContainers:[r]}}function yt(e,t){switch(e){case"focusin":case"focusout":ot=null;break;case"dragenter":case"dragleave":it=null;break;case"mouseover":case"mouseout":ut=null;break;case"pointerover":case"pointerout":st.delete(t.pointerId);break;case"gotpointercapture":case"lostpointercapture":ct.delete(t.pointerId)}}function ht(e,t,n,r,a,l){return null===e||e.nativeEvent!==l?(e=pt(t,n,r,a,l),null!==t&&null!==(t=Jr(t))&&tt(t),e):(e.eventSystemFlags|=r,t=e.targetContainers,null!==a&&-1===t.indexOf(a)&&t.push(a),e)}function gt(e){var t=Xr(e.target);if(null!==t){var n=$e(t);if(null!==n)if(13===(t=n.tag)){if(null!==(t=qe(n)))return e.blockedOn=t,void rt(e.lanePriority,(function(){l.unstable_runWithPriority(e.priority,(function(){nt(n)}))}))}else if(3===t&&n.stateNode.hydrate)return void(e.blockedOn=3===n.tag?n.stateNode.containerInfo:null)}e.blockedOn=null}function mt(e){if(null!==e.blockedOn)return!1;for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n)return null!==(t=Jr(n))&&tt(t),e.blockedOn=n,!1;t.shift()}return!0}function vt(e,t,n){mt(e)&&n.delete(t)}function bt(){for(at=!1;0<lt.length;){var e=lt[0];if(null!==e.blockedOn){null!==(e=Jr(e.blockedOn))&&et(e);break}for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n){e.blockedOn=n;break}t.shift()}null===e.blockedOn&&lt.shift()}null!==ot&&mt(ot)&&(ot=null),null!==it&&mt(it)&&(it=null),null!==ut&&mt(ut)&&(ut=null),st.forEach(vt),ct.forEach(vt)}function Mt(e,t){e.blockedOn===t&&(e.blockedOn=null,at||(at=!0,l.unstable_scheduleCallback(l.unstable_NormalPriority,bt)))}function Et(e){function t(t){return Mt(t,e)}if(0<lt.length){Mt(lt[0],e);for(var n=1;n<lt.length;n++){var r=lt[n];r.blockedOn===e&&(r.blockedOn=null)}}for(null!==ot&&Mt(ot,e),null!==it&&Mt(it,e),null!==ut&&Mt(ut,e),st.forEach(t),ct.forEach(t),n=0;n<ft.length;n++)(r=ft[n]).blockedOn===e&&(r.blockedOn=null);for(;0<ft.length&&null===(n=ft[0]).blockedOn;)gt(n),null===n.blockedOn&&ft.shift()}function Lt(e,t){var n={};return n[e.toLowerCase()]=t.toLowerCase(),n["Webkit"+e]="webkit"+t,n["Moz"+e]="moz"+t,n}var Nt={animationend:Lt("Animation","AnimationEnd"),animationiteration:Lt("Animation","AnimationIteration"),animationstart:Lt("Animation","AnimationStart"),transitionend:Lt("Transition","TransitionEnd")},wt={},St={};function xt(e){if(wt[e])return wt[e];if(!Nt[e])return e;var t,n=Nt[e];for(t in n)if(n.hasOwnProperty(t)&&t in St)return wt[e]=n[t];return e}f&&(St=document.createElement("div").style,"AnimationEvent"in window||(delete Nt.animationend.animation,delete Nt.animationiteration.animation,delete Nt.animationstart.animation),"TransitionEvent"in window||delete Nt.transitionend.transition);var kt=xt("animationend"),jt=xt("animationiteration"),Tt=xt("animationstart"),Ct=xt("transitionend"),It=new Map,Dt=new Map,Ot=["abort","abort",kt,"animationEnd",jt,"animationIteration",Tt,"animationStart","canplay","canPlay","canplaythrough","canPlayThrough","durationchange","durationChange","emptied","emptied","encrypted","encrypted","ended","ended","error","error","gotpointercapture","gotPointerCapture","load","load","loadeddata","loadedData","loadedmetadata","loadedMetadata","loadstart","loadStart","lostpointercapture","lostPointerCapture","playing","playing","progress","progress","seeking","seeking","stalled","stalled","suspend","suspend","timeupdate","timeUpdate",Ct,"transitionEnd","waiting","waiting"];function zt(e,t){for(var n=0;n<e.length;n+=2){var r=e[n],a=e[n+1];a="on"+(a[0].toUpperCase()+a.slice(1)),Dt.set(r,t),It.set(r,a),s(a,[r])}}(0,l.unstable_now)();var At=8;function _t(e){if(0!=(1&e))return At=15,1;if(0!=(2&e))return At=14,2;if(0!=(4&e))return At=13,4;var t=24&e;return 0!==t?(At=12,t):0!=(32&e)?(At=11,32):0!=(t=192&e)?(At=10,t):0!=(256&e)?(At=9,256):0!=(t=3584&e)?(At=8,t):0!=(4096&e)?(At=7,4096):0!=(t=4186112&e)?(At=6,t):0!=(t=62914560&e)?(At=5,t):67108864&e?(At=4,67108864):0!=(134217728&e)?(At=3,134217728):0!=(t=805306368&e)?(At=2,t):0!=(1073741824&e)?(At=1,1073741824):(At=8,e)}function Pt(e,t){var n=e.pendingLanes;if(0===n)return At=0;var r=0,a=0,l=e.expiredLanes,o=e.suspendedLanes,i=e.pingedLanes;if(0!==l)r=l,a=At=15;else if(0!=(l=134217727&n)){var u=l&~o;0!==u?(r=_t(u),a=At):0!=(i&=l)&&(r=_t(i),a=At)}else 0!=(l=n&~o)?(r=_t(l),a=At):0!==i&&(r=_t(i),a=At);if(0===r)return 0;if(r=n&((0>(r=31-Vt(r))?0:1<<r)<<1)-1,0!==t&&t!==r&&0==(t&o)){if(_t(t),a<=At)return t;At=a}if(0!==(t=e.entangledLanes))for(e=e.entanglements,t&=r;0<t;)a=1<<(n=31-Vt(t)),r|=e[n],t&=~a;return r}function Ut(e){return 0!=(e=-1073741825&e.pendingLanes)?e:1073741824&e?1073741824:0}function Yt(e,t){switch(e){case 15:return 1;case 14:return 2;case 12:return 0===(e=Qt(24&~t))?Yt(10,t):e;case 10:return 0===(e=Qt(192&~t))?Yt(8,t):e;case 8:return 0===(e=Qt(3584&~t))&&0===(e=Qt(4186112&~t))&&(e=512),e;case 2:return 0===(t=Qt(805306368&~t))&&(t=268435456),t}throw Error(o(358,e))}function Qt(e){return e&-e}function Rt(e){for(var t=[],n=0;31>n;n++)t.push(e);return t}function Ft(e,t,n){e.pendingLanes|=t;var r=t-1;e.suspendedLanes&=r,e.pingedLanes&=r,(e=e.eventTimes)[t=31-Vt(t)]=n}var Vt=Math.clz32?Math.clz32:function(e){return 0===e?32:31-(Bt(e)/Wt|0)|0},Bt=Math.log,Wt=Math.LN2,Ht=l.unstable_UserBlockingPriority,Kt=l.unstable_runWithPriority,Gt=!0;function $t(e,t,n,r){_e||ze();var a=Zt,l=_e;_e=!0;try{Oe(a,e,t,n,r)}finally{(_e=l)||Ue()}}function qt(e,t,n,r){Kt(Ht,Zt.bind(null,e,t,n,r))}function Zt(e,t,n,r){var a;if(Gt)if((a=0==(4&t))&&0<lt.length&&-1<dt.indexOf(e))e=pt(null,e,t,n,r),lt.push(e);else{var l=Xt(e,t,n,r);if(null===l)a&&yt(e,r);else{if(a){if(-1<dt.indexOf(e))return e=pt(l,e,t,n,r),void lt.push(e);if(function(e,t,n,r,a){switch(t){case"focusin":return ot=ht(ot,e,t,n,r,a),!0;case"dragenter":return it=ht(it,e,t,n,r,a),!0;case"mouseover":return ut=ht(ut,e,t,n,r,a),!0;case"pointerover":var l=a.pointerId;return st.set(l,ht(st.get(l)||null,e,t,n,r,a)),!0;case"gotpointercapture":return l=a.pointerId,ct.set(l,ht(ct.get(l)||null,e,t,n,r,a)),!0}return!1}(l,e,t,n,r))return;yt(e,r)}Ir(e,t,r,null,n)}}}function Xt(e,t,n,r){var a=Se(r);if(null!==(a=Xr(a))){var l=$e(a);if(null===l)a=null;else{var o=l.tag;if(13===o){if(null!==(a=qe(l)))return a;a=null}else if(3===o){if(l.stateNode.hydrate)return 3===l.tag?l.stateNode.containerInfo:null;a=null}else l!==a&&(a=null)}}return Ir(e,t,r,a,n),null}var Jt=null,en=null,tn=null;function nn(){if(tn)return tn;var e,t,n=en,r=n.length,a="value"in Jt?Jt.value:Jt.textContent,l=a.length;for(e=0;e<r&&n[e]===a[e];e++);var o=r-e;for(t=1;t<=o&&n[r-t]===a[l-t];t++);return tn=a.slice(e,1<t?1-t:void 0)}function rn(e){var t=e.keyCode;return"charCode"in e?0===(e=e.charCode)&&13===t&&(e=13):e=t,10===e&&(e=13),32<=e||13===e?e:0}function an(){return!0}function ln(){return!1}function on(e){function t(t,n,r,a,l){for(var o in this._reactName=t,this._targetInst=r,this.type=n,this.nativeEvent=a,this.target=l,this.currentTarget=null,e)e.hasOwnProperty(o)&&(t=e[o],this[o]=t?t(a):a[o]);return this.isDefaultPrevented=(null!=a.defaultPrevented?a.defaultPrevented:!1===a.returnValue)?an:ln,this.isPropagationStopped=ln,this}return a(t.prototype,{preventDefault:function(){this.defaultPrevented=!0;var e=this.nativeEvent;e&&(e.preventDefault?e.preventDefault():"unknown"!=typeof e.returnValue&&(e.returnValue=!1),this.isDefaultPrevented=an)},stopPropagation:function(){var e=this.nativeEvent;e&&(e.stopPropagation?e.stopPropagation():"unknown"!=typeof e.cancelBubble&&(e.cancelBubble=!0),this.isPropagationStopped=an)},persist:function(){},isPersistent:an}),t}var un,sn,cn,fn={eventPhase:0,bubbles:0,cancelable:0,timeStamp:function(e){return e.timeStamp||Date.now()},defaultPrevented:0,isTrusted:0},dn=on(fn),pn=a({},fn,{view:0,detail:0}),yn=on(pn),hn=a({},pn,{screenX:0,screenY:0,clientX:0,clientY:0,pageX:0,pageY:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,getModifierState:xn,button:0,buttons:0,relatedTarget:function(e){return void 0===e.relatedTarget?e.fromElement===e.srcElement?e.toElement:e.fromElement:e.relatedTarget},movementX:function(e){return"movementX"in e?e.movementX:(e!==cn&&(cn&&"mousemove"===e.type?(un=e.screenX-cn.screenX,sn=e.screenY-cn.screenY):sn=un=0,cn=e),un)},movementY:function(e){return"movementY"in e?e.movementY:sn}}),gn=on(hn),mn=on(a({},hn,{dataTransfer:0})),vn=on(a({},pn,{relatedTarget:0})),bn=on(a({},fn,{animationName:0,elapsedTime:0,pseudoElement:0})),Mn=on(a({},fn,{clipboardData:function(e){return"clipboardData"in e?e.clipboardData:window.clipboardData}})),En=on(a({},fn,{data:0})),Ln={Esc:"Escape",Spacebar:" ",Left:"ArrowLeft",Up:"ArrowUp",Right:"ArrowRight",Down:"ArrowDown",Del:"Delete",Win:"OS",Menu:"ContextMenu",Apps:"ContextMenu",Scroll:"ScrollLock",MozPrintableKey:"Unidentified"},Nn={8:"Backspace",9:"Tab",12:"Clear",13:"Enter",16:"Shift",17:"Control",18:"Alt",19:"Pause",20:"CapsLock",27:"Escape",32:" ",33:"PageUp",34:"PageDown",35:"End",36:"Home",37:"ArrowLeft",38:"ArrowUp",39:"ArrowRight",40:"ArrowDown",45:"Insert",46:"Delete",112:"F1",113:"F2",114:"F3",115:"F4",116:"F5",117:"F6",118:"F7",119:"F8",120:"F9",121:"F10",122:"F11",123:"F12",144:"NumLock",145:"ScrollLock",224:"Meta"},wn={Alt:"altKey",Control:"ctrlKey",Meta:"metaKey",Shift:"shiftKey"};function Sn(e){var t=this.nativeEvent;return t.getModifierState?t.getModifierState(e):!!(e=wn[e])&&!!t[e]}function xn(){return Sn}var kn=on(a({},pn,{key:function(e){if(e.key){var t=Ln[e.key]||e.key;if("Unidentified"!==t)return t}return"keypress"===e.type?13===(e=rn(e))?"Enter":String.fromCharCode(e):"keydown"===e.type||"keyup"===e.type?Nn[e.keyCode]||"Unidentified":""},code:0,location:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,repeat:0,locale:0,getModifierState:xn,charCode:function(e){return"keypress"===e.type?rn(e):0},keyCode:function(e){return"keydown"===e.type||"keyup"===e.type?e.keyCode:0},which:function(e){return"keypress"===e.type?rn(e):"keydown"===e.type||"keyup"===e.type?e.keyCode:0}})),jn=on(a({},hn,{pointerId:0,width:0,height:0,pressure:0,tangentialPressure:0,tiltX:0,tiltY:0,twist:0,pointerType:0,isPrimary:0})),Tn=on(a({},pn,{touches:0,targetTouches:0,changedTouches:0,altKey:0,metaKey:0,ctrlKey:0,shiftKey:0,getModifierState:xn})),Cn=on(a({},fn,{propertyName:0,elapsedTime:0,pseudoElement:0})),In=on(a({},hn,{deltaX:function(e){return"deltaX"in e?e.deltaX:"wheelDeltaX"in e?-e.wheelDeltaX:0},deltaY:function(e){return"deltaY"in e?e.deltaY:"wheelDeltaY"in e?-e.wheelDeltaY:"wheelDelta"in e?-e.wheelDelta:0},deltaZ:0,deltaMode:0})),Dn=[9,13,27,32],On=f&&"CompositionEvent"in window,zn=null;f&&"documentMode"in document&&(zn=document.documentMode);var An=f&&"TextEvent"in window&&!zn,_n=f&&(!On||zn&&8<zn&&11>=zn),Pn=String.fromCharCode(32),Un=!1;function Yn(e,t){switch(e){case"keyup":return-1!==Dn.indexOf(t.keyCode);case"keydown":return 229!==t.keyCode;case"keypress":case"mousedown":case"focusout":return!0;default:return!1}}function Qn(e){return"object"==typeof(e=e.detail)&&"data"in e?e.data:null}var Rn=!1,Fn={color:!0,date:!0,datetime:!0,"datetime-local":!0,email:!0,month:!0,number:!0,password:!0,range:!0,search:!0,tel:!0,text:!0,time:!0,url:!0,week:!0};function Vn(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return"input"===t?!!Fn[e.type]:"textarea"===t}function Bn(e,t,n,r){Ce(r),0<(t=Or(t,"onChange")).length&&(n=new dn("onChange","change",null,n,r),e.push({event:n,listeners:t}))}var Wn=null,Hn=null;function Kn(e){Sr(e,0)}function Gn(e){if(Z(ea(e)))return e}function $n(e,t){if("change"===e)return t}var qn=!1;if(f){var Zn;if(f){var Xn="oninput"in document;if(!Xn){var Jn=document.createElement("div");Jn.setAttribute("oninput","return;"),Xn="function"==typeof Jn.oninput}Zn=Xn}else Zn=!1;qn=Zn&&(!document.documentMode||9<document.documentMode)}function er(){Wn&&(Wn.detachEvent("onpropertychange",tr),Hn=Wn=null)}function tr(e){if("value"===e.propertyName&&Gn(Hn)){var t=[];if(Bn(t,Hn,e,Se(e)),e=Kn,_e)e(t);else{_e=!0;try{De(e,t)}finally{_e=!1,Ue()}}}}function nr(e,t,n){"focusin"===e?(er(),Hn=n,(Wn=t).attachEvent("onpropertychange",tr)):"focusout"===e&&er()}function rr(e){if("selectionchange"===e||"keyup"===e||"keydown"===e)return Gn(Hn)}function ar(e,t){if("click"===e)return Gn(t)}function lr(e,t){if("input"===e||"change"===e)return Gn(t)}var or="function"==typeof Object.is?Object.is:function(e,t){return e===t&&(0!==e||1/e==1/t)||e!=e&&t!=t},ir=Object.prototype.hasOwnProperty;function ur(e,t){if(or(e,t))return!0;if("object"!=typeof e||null===e||"object"!=typeof t||null===t)return!1;var n=Object.keys(e),r=Object.keys(t);if(n.length!==r.length)return!1;for(r=0;r<n.length;r++)if(!ir.call(t,n[r])||!or(e[n[r]],t[n[r]]))return!1;return!0}function sr(e){for(;e&&e.firstChild;)e=e.firstChild;return e}function cr(e,t){var n,r=sr(e);for(e=0;r;){if(3===r.nodeType){if(n=e+r.textContent.length,e<=t&&n>=t)return{node:r,offset:t-e};e=n}e:{for(;r;){if(r.nextSibling){r=r.nextSibling;break e}r=r.parentNode}r=void 0}r=sr(r)}}function fr(e,t){return!(!e||!t)&&(e===t||(!e||3!==e.nodeType)&&(t&&3===t.nodeType?fr(e,t.parentNode):"contains"in e?e.contains(t):!!e.compareDocumentPosition&&!!(16&e.compareDocumentPosition(t))))}function dr(){for(var e=window,t=X();t instanceof e.HTMLIFrameElement;){try{var n="string"==typeof t.contentWindow.location.href}catch(e){n=!1}if(!n)break;t=X((e=t.contentWindow).document)}return t}function pr(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return t&&("input"===t&&("text"===e.type||"search"===e.type||"tel"===e.type||"url"===e.type||"password"===e.type)||"textarea"===t||"true"===e.contentEditable)}var yr=f&&"documentMode"in document&&11>=document.documentMode,hr=null,gr=null,mr=null,vr=!1;function br(e,t,n){var r=n.window===n?n.document:9===n.nodeType?n:n.ownerDocument;vr||null==hr||hr!==X(r)||(r="selectionStart"in(r=hr)&&pr(r)?{start:r.selectionStart,end:r.selectionEnd}:{anchorNode:(r=(r.ownerDocument&&r.ownerDocument.defaultView||window).getSelection()).anchorNode,anchorOffset:r.anchorOffset,focusNode:r.focusNode,focusOffset:r.focusOffset},mr&&ur(mr,r)||(mr=r,0<(r=Or(gr,"onSelect")).length&&(t=new dn("onSelect","select",null,t,n),e.push({event:t,listeners:r}),t.target=hr)))}zt("cancel cancel click click close close contextmenu contextMenu copy copy cut cut auxclick auxClick dblclick doubleClick dragend dragEnd dragstart dragStart drop drop focusin focus focusout blur input input invalid invalid keydown keyDown keypress keyPress keyup keyUp mousedown mouseDown mouseup mouseUp paste paste pause pause play play pointercancel pointerCancel pointerdown pointerDown pointerup pointerUp ratechange rateChange reset reset seeked seeked submit submit touchcancel touchCancel touchend touchEnd touchstart touchStart volumechange volumeChange".split(" "),0),zt("drag drag dragenter dragEnter dragexit dragExit dragleave dragLeave dragover dragOver mousemove mouseMove mouseout mouseOut mouseover mouseOver pointermove pointerMove pointerout pointerOut pointerover pointerOver scroll scroll toggle toggle touchmove touchMove wheel wheel".split(" "),1),zt(Ot,2);for(var Mr="change selectionchange textInput compositionstart compositionend compositionupdate".split(" "),Er=0;Er<Mr.length;Er++)Dt.set(Mr[Er],0);c("onMouseEnter",["mouseout","mouseover"]),c("onMouseLeave",["mouseout","mouseover"]),c("onPointerEnter",["pointerout","pointerover"]),c("onPointerLeave",["pointerout","pointerover"]),s("onChange","change click focusin focusout input keydown keyup selectionchange".split(" ")),s("onSelect","focusout contextmenu dragend focusin keydown keyup mousedown mouseup selectionchange".split(" ")),s("onBeforeInput",["compositionend","keypress","textInput","paste"]),s("onCompositionEnd","compositionend focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionStart","compositionstart focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionUpdate","compositionupdate focusout keydown keypress keyup mousedown".split(" "));var Lr="abort canplay canplaythrough durationchange emptied encrypted ended error loadeddata loadedmetadata loadstart pause play playing progress ratechange seeked seeking stalled suspend timeupdate volumechange waiting".split(" "),Nr=new Set("cancel close invalid load scroll toggle".split(" ").concat(Lr));function wr(e,t,n){var r=e.type||"unknown-event";e.currentTarget=n,function(e,t,n,r,a,l,i,u,s){if(Ge.apply(this,arguments),Ve){if(!Ve)throw Error(o(198));var c=Be;Ve=!1,Be=null,We||(We=!0,He=c)}}(r,t,void 0,e),e.currentTarget=null}function Sr(e,t){t=0!=(4&t);for(var n=0;n<e.length;n++){var r=e[n],a=r.event;r=r.listeners;e:{var l=void 0;if(t)for(var o=r.length-1;0<=o;o--){var i=r[o],u=i.instance,s=i.currentTarget;if(i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}else for(o=0;o<r.length;o++){if(u=(i=r[o]).instance,s=i.currentTarget,i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}}}if(We)throw e=He,We=!1,He=null,e}function xr(e,t){var n=na(t),r=e+"__bubble";n.has(r)||(Cr(t,e,2,!1),n.add(r))}var kr="_reactListening"+Math.random().toString(36).slice(2);function jr(e){e[kr]||(e[kr]=!0,i.forEach((function(t){Nr.has(t)||Tr(t,!1,e,null),Tr(t,!0,e,null)})))}function Tr(e,t,n,r){var a=4<arguments.length&&void 0!==arguments[4]?arguments[4]:0,l=n;if("selectionchange"===e&&9!==n.nodeType&&(l=n.ownerDocument),null!==r&&!t&&Nr.has(e)){if("scroll"!==e)return;a|=2,l=r}var o=na(l),i=e+"__"+(t?"capture":"bubble");o.has(i)||(t&&(a|=4),Cr(l,e,a,t),o.add(i))}function Cr(e,t,n,r){var a=Dt.get(t);switch(void 0===a?2:a){case 0:a=$t;break;case 1:a=qt;break;default:a=Zt}n=a.bind(null,t,n,e),a=void 0,!Qe||"touchstart"!==t&&"touchmove"!==t&&"wheel"!==t||(a=!0),r?void 0!==a?e.addEventListener(t,n,{capture:!0,passive:a}):e.addEventListener(t,n,!0):void 0!==a?e.addEventListener(t,n,{passive:a}):e.addEventListener(t,n,!1)}function Ir(e,t,n,r,a){var l=r;if(0==(1&t)&&0==(2&t)&&null!==r)e:for(;;){if(null===r)return;var o=r.tag;if(3===o||4===o){var i=r.stateNode.containerInfo;if(i===a||8===i.nodeType&&i.parentNode===a)break;if(4===o)for(o=r.return;null!==o;){var u=o.tag;if((3===u||4===u)&&((u=o.stateNode.containerInfo)===a||8===u.nodeType&&u.parentNode===a))return;o=o.return}for(;null!==i;){if(null===(o=Xr(i)))return;if(5===(u=o.tag)||6===u){r=l=o;continue e}i=i.parentNode}}r=r.return}!function(e,t,n){if(Pe)return e();Pe=!0;try{Ae(e,t,n)}finally{Pe=!1,Ue()}}((function(){var r=l,a=Se(n),o=[];e:{var i=It.get(e);if(void 0!==i){var u=dn,s=e;switch(e){case"keypress":if(0===rn(n))break e;case"keydown":case"keyup":u=kn;break;case"focusin":s="focus",u=vn;break;case"focusout":s="blur",u=vn;break;case"beforeblur":case"afterblur":u=vn;break;case"click":if(2===n.button)break e;case"auxclick":case"dblclick":case"mousedown":case"mousemove":case"mouseup":case"mouseout":case"mouseover":case"contextmenu":u=gn;break;case"drag":case"dragend":case"dragenter":case"dragexit":case"dragleave":case"dragover":case"dragstart":case"drop":u=mn;break;case"touchcancel":case"touchend":case"touchmove":case"touchstart":u=Tn;break;case kt:case jt:case Tt:u=bn;break;case Ct:u=Cn;break;case"scroll":u=yn;break;case"wheel":u=In;break;case"copy":case"cut":case"paste":u=Mn;break;case"gotpointercapture":case"lostpointercapture":case"pointercancel":case"pointerdown":case"pointermove":case"pointerout":case"pointerover":case"pointerup":u=jn}var c=0!=(4&t),f=!c&&"scroll"===e,d=c?null!==i?i+"Capture":null:i;c=[];for(var p,y=r;null!==y;){var h=(p=y).stateNode;if(5===p.tag&&null!==h&&(p=h,null!==d&&null!=(h=Ye(y,d))&&c.push(Dr(y,h,p))),f)break;y=y.return}0<c.length&&(i=new u(i,s,null,n,a),o.push({event:i,listeners:c}))}}if(0==(7&t)){if(u="mouseout"===e||"pointerout"===e,(!(i="mouseover"===e||"pointerover"===e)||0!=(16&t)||!(s=n.relatedTarget||n.fromElement)||!Xr(s)&&!s[qr])&&(u||i)&&(i=a.window===a?a:(i=a.ownerDocument)?i.defaultView||i.parentWindow:window,u?(u=r,null!==(s=(s=n.relatedTarget||n.toElement)?Xr(s):null)&&(s!==(f=$e(s))||5!==s.tag&&6!==s.tag)&&(s=null)):(u=null,s=r),u!==s)){if(c=gn,h="onMouseLeave",d="onMouseEnter",y="mouse","pointerout"!==e&&"pointerover"!==e||(c=jn,h="onPointerLeave",d="onPointerEnter",y="pointer"),f=null==u?i:ea(u),p=null==s?i:ea(s),(i=new c(h,y+"leave",u,n,a)).target=f,i.relatedTarget=p,h=null,Xr(a)===r&&((c=new c(d,y+"enter",s,n,a)).target=p,c.relatedTarget=f,h=c),f=h,u&&s)e:{for(d=s,y=0,p=c=u;p;p=zr(p))y++;for(p=0,h=d;h;h=zr(h))p++;for(;0<y-p;)c=zr(c),y--;for(;0<p-y;)d=zr(d),p--;for(;y--;){if(c===d||null!==d&&c===d.alternate)break e;c=zr(c),d=zr(d)}c=null}else c=null;null!==u&&Ar(o,i,u,c,!1),null!==s&&null!==f&&Ar(o,f,s,c,!0)}if("select"===(u=(i=r?ea(r):window).nodeName&&i.nodeName.toLowerCase())||"input"===u&&"file"===i.type)var g=$n;else if(Vn(i))if(qn)g=lr;else{g=rr;var m=nr}else(u=i.nodeName)&&"input"===u.toLowerCase()&&("checkbox"===i.type||"radio"===i.type)&&(g=ar);switch(g&&(g=g(e,r))?Bn(o,g,n,a):(m&&m(e,i,r),"focusout"===e&&(m=i._wrapperState)&&m.controlled&&"number"===i.type&&ae(i,"number",i.value)),m=r?ea(r):window,e){case"focusin":(Vn(m)||"true"===m.contentEditable)&&(hr=m,gr=r,mr=null);break;case"focusout":mr=gr=hr=null;break;case"mousedown":vr=!0;break;case"contextmenu":case"mouseup":case"dragend":vr=!1,br(o,n,a);break;case"selectionchange":if(yr)break;case"keydown":case"keyup":br(o,n,a)}var v;if(On)e:{switch(e){case"compositionstart":var b="onCompositionStart";break e;case"compositionend":b="onCompositionEnd";break e;case"compositionupdate":b="onCompositionUpdate";break e}b=void 0}else Rn?Yn(e,n)&&(b="onCompositionEnd"):"keydown"===e&&229===n.keyCode&&(b="onCompositionStart");b&&(_n&&"ko"!==n.locale&&(Rn||"onCompositionStart"!==b?"onCompositionEnd"===b&&Rn&&(v=nn()):(en="value"in(Jt=a)?Jt.value:Jt.textContent,Rn=!0)),0<(m=Or(r,b)).length&&(b=new En(b,e,null,n,a),o.push({event:b,listeners:m}),(v||null!==(v=Qn(n)))&&(b.data=v))),(v=An?function(e,t){switch(e){case"compositionend":return Qn(t);case"keypress":return 32!==t.which?null:(Un=!0,Pn);case"textInput":return(e=t.data)===Pn&&Un?null:e;default:return null}}(e,n):function(e,t){if(Rn)return"compositionend"===e||!On&&Yn(e,t)?(e=nn(),tn=en=Jt=null,Rn=!1,e):null;switch(e){case"paste":return null;case"keypress":if(!(t.ctrlKey||t.altKey||t.metaKey)||t.ctrlKey&&t.altKey){if(t.char&&1<t.char.length)return t.char;if(t.which)return String.fromCharCode(t.which)}return null;case"compositionend":return _n&&"ko"!==t.locale?null:t.data;default:return null}}(e,n))&&0<(r=Or(r,"onBeforeInput")).length&&(a=new En("onBeforeInput","beforeinput",null,n,a),o.push({event:a,listeners:r}),a.data=v)}Sr(o,t)}))}function Dr(e,t,n){return{instance:e,listener:t,currentTarget:n}}function Or(e,t){for(var n=t+"Capture",r=[];null!==e;){var a=e,l=a.stateNode;5===a.tag&&null!==l&&(a=l,null!=(l=Ye(e,n))&&r.unshift(Dr(e,l,a)),null!=(l=Ye(e,t))&&r.push(Dr(e,l,a))),e=e.return}return r}function zr(e){if(null===e)return null;do{e=e.return}while(e&&5!==e.tag);return e||null}function Ar(e,t,n,r,a){for(var l=t._reactName,o=[];null!==n&&n!==r;){var i=n,u=i.alternate,s=i.stateNode;if(null!==u&&u===r)break;5===i.tag&&null!==s&&(i=s,a?null!=(u=Ye(n,l))&&o.unshift(Dr(n,u,i)):a||null!=(u=Ye(n,l))&&o.push(Dr(n,u,i))),n=n.return}0!==o.length&&e.push({event:t,listeners:o})}function _r(){}var Pr=null,Ur=null;function Yr(e,t){switch(e){case"button":case"input":case"select":case"textarea":return!!t.autoFocus}return!1}function Qr(e,t){return"textarea"===e||"option"===e||"noscript"===e||"string"==typeof t.children||"number"==typeof t.children||"object"==typeof t.dangerouslySetInnerHTML&&null!==t.dangerouslySetInnerHTML&&null!=t.dangerouslySetInnerHTML.__html}var Rr="function"==typeof setTimeout?setTimeout:void 0,Fr="function"==typeof clearTimeout?clearTimeout:void 0;function Vr(e){(1===e.nodeType||9===e.nodeType&&null!=(e=e.body))&&(e.textContent="")}function Br(e){for(;null!=e;e=e.nextSibling){var t=e.nodeType;if(1===t||3===t)break}return e}function Wr(e){e=e.previousSibling;for(var t=0;e;){if(8===e.nodeType){var n=e.data;if("$"===n||"$!"===n||"$?"===n){if(0===t)return e;t--}else"/$"===n&&t++}e=e.previousSibling}return null}var Hr=0,Kr=Math.random().toString(36).slice(2),Gr="__reactFiber$"+Kr,$r="__reactProps$"+Kr,qr="__reactContainer$"+Kr,Zr="__reactEvents$"+Kr;function Xr(e){var t=e[Gr];if(t)return t;for(var n=e.parentNode;n;){if(t=n[qr]||n[Gr]){if(n=t.alternate,null!==t.child||null!==n&&null!==n.child)for(e=Wr(e);null!==e;){if(n=e[Gr])return n;e=Wr(e)}return t}n=(e=n).parentNode}return null}function Jr(e){return!(e=e[Gr]||e[qr])||5!==e.tag&&6!==e.tag&&13!==e.tag&&3!==e.tag?null:e}function ea(e){if(5===e.tag||6===e.tag)return e.stateNode;throw Error(o(33))}function ta(e){return e[$r]||null}function na(e){var t=e[Zr];return void 0===t&&(t=e[Zr]=new Set),t}var ra=[],aa=-1;function la(e){return{current:e}}function oa(e){0>aa||(e.current=ra[aa],ra[aa]=null,aa--)}function ia(e,t){aa++,ra[aa]=e.current,e.current=t}var ua={},sa=la(ua),ca=la(!1),fa=ua;function da(e,t){var n=e.type.contextTypes;if(!n)return ua;var r=e.stateNode;if(r&&r.__reactInternalMemoizedUnmaskedChildContext===t)return r.__reactInternalMemoizedMaskedChildContext;var a,l={};for(a in n)l[a]=t[a];return r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=t,e.__reactInternalMemoizedMaskedChildContext=l),l}function pa(e){return null!=e.childContextTypes}function ya(){oa(ca),oa(sa)}function ha(e,t,n){if(sa.current!==ua)throw Error(o(168));ia(sa,t),ia(ca,n)}function ga(e,t,n){var r=e.stateNode;if(e=t.childContextTypes,"function"!=typeof r.getChildContext)return n;for(var l in r=r.getChildContext())if(!(l in e))throw Error(o(108,K(t)||"Unknown",l));return a({},n,r)}function ma(e){return e=(e=e.stateNode)&&e.__reactInternalMemoizedMergedChildContext||ua,fa=sa.current,ia(sa,e),ia(ca,ca.current),!0}function va(e,t,n){var r=e.stateNode;if(!r)throw Error(o(169));n?(e=ga(e,t,fa),r.__reactInternalMemoizedMergedChildContext=e,oa(ca),oa(sa),ia(sa,e)):oa(ca),ia(ca,n)}var ba=null,Ma=null,Ea=l.unstable_runWithPriority,La=l.unstable_scheduleCallback,Na=l.unstable_cancelCallback,wa=l.unstable_shouldYield,Sa=l.unstable_requestPaint,xa=l.unstable_now,ka=l.unstable_getCurrentPriorityLevel,ja=l.unstable_ImmediatePriority,Ta=l.unstable_UserBlockingPriority,Ca=l.unstable_NormalPriority,Ia=l.unstable_LowPriority,Da=l.unstable_IdlePriority,Oa={},za=void 0!==Sa?Sa:function(){},Aa=null,_a=null,Pa=!1,Ua=xa(),Ya=1e4>Ua?xa:function(){return xa()-Ua};function Qa(){switch(ka()){case ja:return 99;case Ta:return 98;case Ca:return 97;case Ia:return 96;case Da:return 95;default:throw Error(o(332))}}function Ra(e){switch(e){case 99:return ja;case 98:return Ta;case 97:return Ca;case 96:return Ia;case 95:return Da;default:throw Error(o(332))}}function Fa(e,t){return e=Ra(e),Ea(e,t)}function Va(e,t,n){return e=Ra(e),La(e,t,n)}function Ba(){if(null!==_a){var e=_a;_a=null,Na(e)}Wa()}function Wa(){if(!Pa&&null!==Aa){Pa=!0;var e=0;try{var t=Aa;Fa(99,(function(){for(;e<t.length;e++){var n=t[e];do{n=n(!0)}while(null!==n)}})),Aa=null}catch(t){throw null!==Aa&&(Aa=Aa.slice(e+1)),La(ja,Ba),t}finally{Pa=!1}}}var Ha=E.ReactCurrentBatchConfig;function Ka(e,t){if(e&&e.defaultProps){for(var n in t=a({},t),e=e.defaultProps)void 0===t[n]&&(t[n]=e[n]);return t}return t}var Ga=la(null),$a=null,qa=null,Za=null;function Xa(){Za=qa=$a=null}function Ja(e){var t=Ga.current;oa(Ga),e.type._context._currentValue=t}function el(e,t){for(;null!==e;){var n=e.alternate;if((e.childLanes&t)===t){if(null===n||(n.childLanes&t)===t)break;n.childLanes|=t}else e.childLanes|=t,null!==n&&(n.childLanes|=t);e=e.return}}function tl(e,t){$a=e,Za=qa=null,null!==(e=e.dependencies)&&null!==e.firstContext&&(0!=(e.lanes&t)&&(Oo=!0),e.firstContext=null)}function nl(e,t){if(Za!==e&&!1!==t&&0!==t)if("number"==typeof t&&1073741823!==t||(Za=e,t=1073741823),t={context:e,observedBits:t,next:null},null===qa){if(null===$a)throw Error(o(308));qa=t,$a.dependencies={lanes:0,firstContext:t,responders:null}}else qa=qa.next=t;return e._currentValue}var rl=!1;function al(e){e.updateQueue={baseState:e.memoizedState,firstBaseUpdate:null,lastBaseUpdate:null,shared:{pending:null},effects:null}}function ll(e,t){e=e.updateQueue,t.updateQueue===e&&(t.updateQueue={baseState:e.baseState,firstBaseUpdate:e.firstBaseUpdate,lastBaseUpdate:e.lastBaseUpdate,shared:e.shared,effects:e.effects})}function ol(e,t){return{eventTime:e,lane:t,tag:0,payload:null,callback:null,next:null}}function il(e,t){if(null!==(e=e.updateQueue)){var n=(e=e.shared).pending;null===n?t.next=t:(t.next=n.next,n.next=t),e.pending=t}}function ul(e,t){var n=e.updateQueue,r=e.alternate;if(null!==r&&n===(r=r.updateQueue)){var a=null,l=null;if(null!==(n=n.firstBaseUpdate)){do{var o={eventTime:n.eventTime,lane:n.lane,tag:n.tag,payload:n.payload,callback:n.callback,next:null};null===l?a=l=o:l=l.next=o,n=n.next}while(null!==n);null===l?a=l=t:l=l.next=t}else a=l=t;return n={baseState:r.baseState,firstBaseUpdate:a,lastBaseUpdate:l,shared:r.shared,effects:r.effects},void(e.updateQueue=n)}null===(e=n.lastBaseUpdate)?n.firstBaseUpdate=t:e.next=t,n.lastBaseUpdate=t}function sl(e,t,n,r){var l=e.updateQueue;rl=!1;var o=l.firstBaseUpdate,i=l.lastBaseUpdate,u=l.shared.pending;if(null!==u){l.shared.pending=null;var s=u,c=s.next;s.next=null,null===i?o=c:i.next=c,i=s;var f=e.alternate;if(null!==f){var d=(f=f.updateQueue).lastBaseUpdate;d!==i&&(null===d?f.firstBaseUpdate=c:d.next=c,f.lastBaseUpdate=s)}}if(null!==o){for(d=l.baseState,i=0,f=c=s=null;;){u=o.lane;var p=o.eventTime;if((r&u)===u){null!==f&&(f=f.next={eventTime:p,lane:0,tag:o.tag,payload:o.payload,callback:o.callback,next:null});e:{var y=e,h=o;switch(u=t,p=n,h.tag){case 1:if("function"==typeof(y=h.payload)){d=y.call(p,d,u);break e}d=y;break e;case 3:y.flags=-4097&y.flags|64;case 0:if(null==(u="function"==typeof(y=h.payload)?y.call(p,d,u):y))break e;d=a({},d,u);break e;case 2:rl=!0}}null!==o.callback&&(e.flags|=32,null===(u=l.effects)?l.effects=[o]:u.push(o))}else p={eventTime:p,lane:u,tag:o.tag,payload:o.payload,callback:o.callback,next:null},null===f?(c=f=p,s=d):f=f.next=p,i|=u;if(null===(o=o.next)){if(null===(u=l.shared.pending))break;o=u.next,u.next=null,l.lastBaseUpdate=u,l.shared.pending=null}}null===f&&(s=d),l.baseState=s,l.firstBaseUpdate=c,l.lastBaseUpdate=f,Ai|=i,e.lanes=i,e.memoizedState=d}}function cl(e,t,n){if(e=t.effects,t.effects=null,null!==e)for(t=0;t<e.length;t++){var r=e[t],a=r.callback;if(null!==a){if(r.callback=null,r=n,"function"!=typeof a)throw Error(o(191,a));a.call(r)}}}var fl=(new r.Component).refs;function dl(e,t,n,r){n=null==(n=n(r,t=e.memoizedState))?t:a({},t,n),e.memoizedState=n,0===e.lanes&&(e.updateQueue.baseState=n)}var pl={isMounted:function(e){return!!(e=e._reactInternals)&&$e(e)===e},enqueueSetState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueReplaceState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.tag=1,l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueForceUpdate:function(e,t){e=e._reactInternals;var n=ou(),r=iu(e),a=ol(n,r);a.tag=2,null!=t&&(a.callback=t),il(e,a),uu(e,r,n)}};function yl(e,t,n,r,a,l,o){return"function"==typeof(e=e.stateNode).shouldComponentUpdate?e.shouldComponentUpdate(r,l,o):!(t.prototype&&t.prototype.isPureReactComponent&&ur(n,r)&&ur(a,l))}function hl(e,t,n){var r=!1,a=ua,l=t.contextType;return"object"==typeof l&&null!==l?l=nl(l):(a=pa(t)?fa:sa.current,l=(r=null!=(r=t.contextTypes))?da(e,a):ua),t=new t(n,l),e.memoizedState=null!==t.state&&void 0!==t.state?t.state:null,t.updater=pl,e.stateNode=t,t._reactInternals=e,r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=a,e.__reactInternalMemoizedMaskedChildContext=l),t}function gl(e,t,n,r){e=t.state,"function"==typeof t.componentWillReceiveProps&&t.componentWillReceiveProps(n,r),"function"==typeof t.UNSAFE_componentWillReceiveProps&&t.UNSAFE_componentWillReceiveProps(n,r),t.state!==e&&pl.enqueueReplaceState(t,t.state,null)}function ml(e,t,n,r){var a=e.stateNode;a.props=n,a.state=e.memoizedState,a.refs=fl,al(e);var l=t.contextType;"object"==typeof l&&null!==l?a.context=nl(l):(l=pa(t)?fa:sa.current,a.context=da(e,l)),sl(e,n,a,r),a.state=e.memoizedState,"function"==typeof(l=t.getDerivedStateFromProps)&&(dl(e,t,l,n),a.state=e.memoizedState),"function"==typeof t.getDerivedStateFromProps||"function"==typeof a.getSnapshotBeforeUpdate||"function"!=typeof a.UNSAFE_componentWillMount&&"function"!=typeof a.componentWillMount||(t=a.state,"function"==typeof a.componentWillMount&&a.componentWillMount(),"function"==typeof a.UNSAFE_componentWillMount&&a.UNSAFE_componentWillMount(),t!==a.state&&pl.enqueueReplaceState(a,a.state,null),sl(e,n,a,r),a.state=e.memoizedState),"function"==typeof a.componentDidMount&&(e.flags|=4)}var vl=Array.isArray;function bl(e,t,n){if(null!==(e=n.ref)&&"function"!=typeof e&&"object"!=typeof e){if(n._owner){if(n=n._owner){if(1!==n.tag)throw Error(o(309));var r=n.stateNode}if(!r)throw Error(o(147,e));var a=""+e;return null!==t&&null!==t.ref&&"function"==typeof t.ref&&t.ref._stringRef===a?t.ref:((t=function(e){var t=r.refs;t===fl&&(t=r.refs={}),null===e?delete t[a]:t[a]=e})._stringRef=a,t)}if("string"!=typeof e)throw Error(o(284));if(!n._owner)throw Error(o(290,e))}return e}function Ml(e,t){if("textarea"!==e.type)throw Error(o(31,"[object Object]"===Object.prototype.toString.call(t)?"object with keys {"+Object.keys(t).join(", ")+"}":t))}function El(e){function t(t,n){if(e){var r=t.lastEffect;null!==r?(r.nextEffect=n,t.lastEffect=n):t.firstEffect=t.lastEffect=n,n.nextEffect=null,n.flags=8}}function n(n,r){if(!e)return null;for(;null!==r;)t(n,r),r=r.sibling;return null}function r(e,t){for(e=new Map;null!==t;)null!==t.key?e.set(t.key,t):e.set(t.index,t),t=t.sibling;return e}function a(e,t){return(e=Qu(e,t)).index=0,e.sibling=null,e}function l(t,n,r){return t.index=r,e?null!==(r=t.alternate)?(r=r.index)<n?(t.flags=2,n):r:(t.flags=2,n):n}function i(t){return e&&null===t.alternate&&(t.flags=2),t}function u(e,t,n,r){return null===t||6!==t.tag?((t=Bu(n,e.mode,r)).return=e,t):((t=a(t,n)).return=e,t)}function s(e,t,n,r){return null!==t&&t.elementType===n.type?((r=a(t,n.props)).ref=bl(e,t,n),r.return=e,r):((r=Ru(n.type,n.key,n.props,null,e.mode,r)).ref=bl(e,t,n),r.return=e,r)}function c(e,t,n,r){return null===t||4!==t.tag||t.stateNode.containerInfo!==n.containerInfo||t.stateNode.implementation!==n.implementation?((t=Wu(n,e.mode,r)).return=e,t):((t=a(t,n.children||[])).return=e,t)}function f(e,t,n,r,l){return null===t||7!==t.tag?((t=Fu(n,e.mode,r,l)).return=e,t):((t=a(t,n)).return=e,t)}function d(e,t,n){if("string"==typeof t||"number"==typeof t)return(t=Bu(""+t,e.mode,n)).return=e,t;if("object"==typeof t&&null!==t){switch(t.$$typeof){case L:return(n=Ru(t.type,t.key,t.props,null,e.mode,n)).ref=bl(e,null,t),n.return=e,n;case N:return(t=Wu(t,e.mode,n)).return=e,t}if(vl(t)||F(t))return(t=Fu(t,e.mode,n,null)).return=e,t;Ml(e,t)}return null}function p(e,t,n,r){var a=null!==t?t.key:null;if("string"==typeof n||"number"==typeof n)return null!==a?null:u(e,t,""+n,r);if("object"==typeof n&&null!==n){switch(n.$$typeof){case L:return n.key===a?n.type===w?f(e,t,n.props.children,r,a):s(e,t,n,r):null;case N:return n.key===a?c(e,t,n,r):null}if(vl(n)||F(n))return null!==a?null:f(e,t,n,r,null);Ml(e,n)}return null}function y(e,t,n,r,a){if("string"==typeof r||"number"==typeof r)return u(t,e=e.get(n)||null,""+r,a);if("object"==typeof r&&null!==r){switch(r.$$typeof){case L:return e=e.get(null===r.key?n:r.key)||null,r.type===w?f(t,e,r.props.children,a,r.key):s(t,e,r,a);case N:return c(t,e=e.get(null===r.key?n:r.key)||null,r,a)}if(vl(r)||F(r))return f(t,e=e.get(n)||null,r,a,null);Ml(t,r)}return null}function h(a,o,i,u){for(var s=null,c=null,f=o,h=o=0,g=null;null!==f&&h<i.length;h++){f.index>h?(g=f,f=null):g=f.sibling;var m=p(a,f,i[h],u);if(null===m){null===f&&(f=g);break}e&&f&&null===m.alternate&&t(a,f),o=l(m,o,h),null===c?s=m:c.sibling=m,c=m,f=g}if(h===i.length)return n(a,f),s;if(null===f){for(;h<i.length;h++)null!==(f=d(a,i[h],u))&&(o=l(f,o,h),null===c?s=f:c.sibling=f,c=f);return s}for(f=r(a,f);h<i.length;h++)null!==(g=y(f,a,h,i[h],u))&&(e&&null!==g.alternate&&f.delete(null===g.key?h:g.key),o=l(g,o,h),null===c?s=g:c.sibling=g,c=g);return e&&f.forEach((function(e){return t(a,e)})),s}function g(a,i,u,s){var c=F(u);if("function"!=typeof c)throw Error(o(150));if(null==(u=c.call(u)))throw Error(o(151));for(var f=c=null,h=i,g=i=0,m=null,v=u.next();null!==h&&!v.done;g++,v=u.next()){h.index>g?(m=h,h=null):m=h.sibling;var b=p(a,h,v.value,s);if(null===b){null===h&&(h=m);break}e&&h&&null===b.alternate&&t(a,h),i=l(b,i,g),null===f?c=b:f.sibling=b,f=b,h=m}if(v.done)return n(a,h),c;if(null===h){for(;!v.done;g++,v=u.next())null!==(v=d(a,v.value,s))&&(i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return c}for(h=r(a,h);!v.done;g++,v=u.next())null!==(v=y(h,a,g,v.value,s))&&(e&&null!==v.alternate&&h.delete(null===v.key?g:v.key),i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return e&&h.forEach((function(e){return t(a,e)})),c}return function(e,r,l,u){var s="object"==typeof l&&null!==l&&l.type===w&&null===l.key;s&&(l=l.props.children);var c="object"==typeof l&&null!==l;if(c)switch(l.$$typeof){case L:e:{for(c=l.key,s=r;null!==s;){if(s.key===c){switch(s.tag){case 7:if(l.type===w){n(e,s.sibling),(r=a(s,l.props.children)).return=e,e=r;break e}break;default:if(s.elementType===l.type){n(e,s.sibling),(r=a(s,l.props)).ref=bl(e,s,l),r.return=e,e=r;break e}}n(e,s);break}t(e,s),s=s.sibling}l.type===w?((r=Fu(l.props.children,e.mode,u,l.key)).return=e,e=r):((u=Ru(l.type,l.key,l.props,null,e.mode,u)).ref=bl(e,r,l),u.return=e,e=u)}return i(e);case N:e:{for(s=l.key;null!==r;){if(r.key===s){if(4===r.tag&&r.stateNode.containerInfo===l.containerInfo&&r.stateNode.implementation===l.implementation){n(e,r.sibling),(r=a(r,l.children||[])).return=e,e=r;break e}n(e,r);break}t(e,r),r=r.sibling}(r=Wu(l,e.mode,u)).return=e,e=r}return i(e)}if("string"==typeof l||"number"==typeof l)return l=""+l,null!==r&&6===r.tag?(n(e,r.sibling),(r=a(r,l)).return=e,e=r):(n(e,r),(r=Bu(l,e.mode,u)).return=e,e=r),i(e);if(vl(l))return h(e,r,l,u);if(F(l))return g(e,r,l,u);if(c&&Ml(e,l),void 0===l&&!s)switch(e.tag){case 1:case 22:case 0:case 11:case 15:throw Error(o(152,K(e.type)||"Component"))}return n(e,r)}}var Ll=El(!0),Nl=El(!1),wl={},Sl=la(wl),xl=la(wl),kl=la(wl);function jl(e){if(e===wl)throw Error(o(174));return e}function Tl(e,t){switch(ia(kl,t),ia(xl,e),ia(Sl,wl),e=t.nodeType){case 9:case 11:t=(t=t.documentElement)?t.namespaceURI:pe(null,"");break;default:t=pe(t=(e=8===e?t.parentNode:t).namespaceURI||null,e=e.tagName)}oa(Sl),ia(Sl,t)}function Cl(){oa(Sl),oa(xl),oa(kl)}function Il(e){jl(kl.current);var t=jl(Sl.current),n=pe(t,e.type);t!==n&&(ia(xl,e),ia(Sl,n))}function Dl(e){xl.current===e&&(oa(Sl),oa(xl))}var Ol=la(0);function zl(e){for(var t=e;null!==t;){if(13===t.tag){var n=t.memoizedState;if(null!==n&&(null===(n=n.dehydrated)||"$?"===n.data||"$!"===n.data))return t}else if(19===t.tag&&void 0!==t.memoizedProps.revealOrder){if(0!=(64&t.flags))return t}else if(null!==t.child){t.child.return=t,t=t.child;continue}if(t===e)break;for(;null===t.sibling;){if(null===t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}return null}var Al=null,_l=null,Pl=!1;function Ul(e,t){var n=Uu(5,null,null,0);n.elementType="DELETED",n.type="DELETED",n.stateNode=t,n.return=e,n.flags=8,null!==e.lastEffect?(e.lastEffect.nextEffect=n,e.lastEffect=n):e.firstEffect=e.lastEffect=n}function Yl(e,t){switch(e.tag){case 5:var n=e.type;return null!==(t=1!==t.nodeType||n.toLowerCase()!==t.nodeName.toLowerCase()?null:t)&&(e.stateNode=t,!0);case 6:return null!==(t=""===e.pendingProps||3!==t.nodeType?null:t)&&(e.stateNode=t,!0);case 13:default:return!1}}function Ql(e){if(Pl){var t=_l;if(t){var n=t;if(!Yl(e,t)){if(!(t=Br(n.nextSibling))||!Yl(e,t))return e.flags=-1025&e.flags|2,Pl=!1,void(Al=e);Ul(Al,n)}Al=e,_l=Br(t.firstChild)}else e.flags=-1025&e.flags|2,Pl=!1,Al=e}}function Rl(e){for(e=e.return;null!==e&&5!==e.tag&&3!==e.tag&&13!==e.tag;)e=e.return;Al=e}function Fl(e){if(e!==Al)return!1;if(!Pl)return Rl(e),Pl=!0,!1;var t=e.type;if(5!==e.tag||"head"!==t&&"body"!==t&&!Qr(t,e.memoizedProps))for(t=_l;t;)Ul(e,t),t=Br(t.nextSibling);if(Rl(e),13===e.tag){if(!(e=null!==(e=e.memoizedState)?e.dehydrated:null))throw Error(o(317));e:{for(e=e.nextSibling,t=0;e;){if(8===e.nodeType){var n=e.data;if("/$"===n){if(0===t){_l=Br(e.nextSibling);break e}t--}else"$"!==n&&"$!"!==n&&"$?"!==n||t++}e=e.nextSibling}_l=null}}else _l=Al?Br(e.stateNode.nextSibling):null;return!0}function Vl(){_l=Al=null,Pl=!1}var Bl=[];function Wl(){for(var e=0;e<Bl.length;e++)Bl[e]._workInProgressVersionPrimary=null;Bl.length=0}var Hl=E.ReactCurrentDispatcher,Kl=E.ReactCurrentBatchConfig,Gl=0,$l=null,ql=null,Zl=null,Xl=!1,Jl=!1;function eo(){throw Error(o(321))}function to(e,t){if(null===t)return!1;for(var n=0;n<t.length&&n<e.length;n++)if(!or(e[n],t[n]))return!1;return!0}function no(e,t,n,r,a,l){if(Gl=l,$l=t,t.memoizedState=null,t.updateQueue=null,t.lanes=0,Hl.current=null===e||null===e.memoizedState?To:Co,e=n(r,a),Jl){l=0;do{if(Jl=!1,!(25>l))throw Error(o(301));l+=1,Zl=ql=null,t.updateQueue=null,Hl.current=Io,e=n(r,a)}while(Jl)}if(Hl.current=jo,t=null!==ql&&null!==ql.next,Gl=0,Zl=ql=$l=null,Xl=!1,t)throw Error(o(300));return e}function ro(){var e={memoizedState:null,baseState:null,baseQueue:null,queue:null,next:null};return null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e,Zl}function ao(){if(null===ql){var e=$l.alternate;e=null!==e?e.memoizedState:null}else e=ql.next;var t=null===Zl?$l.memoizedState:Zl.next;if(null!==t)Zl=t,ql=e;else{if(null===e)throw Error(o(310));e={memoizedState:(ql=e).memoizedState,baseState:ql.baseState,baseQueue:ql.baseQueue,queue:ql.queue,next:null},null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e}return Zl}function lo(e,t){return"function"==typeof t?t(e):t}function oo(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=ql,a=r.baseQueue,l=n.pending;if(null!==l){if(null!==a){var i=a.next;a.next=l.next,l.next=i}r.baseQueue=a=l,n.pending=null}if(null!==a){a=a.next,r=r.baseState;var u=i=l=null,s=a;do{var c=s.lane;if((Gl&c)===c)null!==u&&(u=u.next={lane:0,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null}),r=s.eagerReducer===e?s.eagerState:e(r,s.action);else{var f={lane:c,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null};null===u?(i=u=f,l=r):u=u.next=f,$l.lanes|=c,Ai|=c}s=s.next}while(null!==s&&s!==a);null===u?l=r:u.next=i,or(r,t.memoizedState)||(Oo=!0),t.memoizedState=r,t.baseState=l,t.baseQueue=u,n.lastRenderedState=r}return[t.memoizedState,n.dispatch]}function io(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=n.dispatch,a=n.pending,l=t.memoizedState;if(null!==a){n.pending=null;var i=a=a.next;do{l=e(l,i.action),i=i.next}while(i!==a);or(l,t.memoizedState)||(Oo=!0),t.memoizedState=l,null===t.baseQueue&&(t.baseState=l),n.lastRenderedState=l}return[l,r]}function uo(e,t,n){var r=t._getVersion;r=r(t._source);var a=t._workInProgressVersionPrimary;if(null!==a?e=a===r:(e=e.mutableReadLanes,(e=(Gl&e)===e)&&(t._workInProgressVersionPrimary=r,Bl.push(t))),e)return n(t._source);throw Bl.push(t),Error(o(350))}function so(e,t,n,r){var a=ki;if(null===a)throw Error(o(349));var l=t._getVersion,i=l(t._source),u=Hl.current,s=u.useState((function(){return uo(a,t,n)})),c=s[1],f=s[0];s=Zl;var d=e.memoizedState,p=d.refs,y=p.getSnapshot,h=d.source;d=d.subscribe;var g=$l;return e.memoizedState={refs:p,source:t,subscribe:r},u.useEffect((function(){p.getSnapshot=n,p.setSnapshot=c;var e=l(t._source);if(!or(i,e)){e=n(t._source),or(f,e)||(c(e),e=iu(g),a.mutableReadLanes|=e&a.pendingLanes),e=a.mutableReadLanes,a.entangledLanes|=e;for(var r=a.entanglements,o=e;0<o;){var u=31-Vt(o),s=1<<u;r[u]|=e,o&=~s}}}),[n,t,r]),u.useEffect((function(){return r(t._source,(function(){var e=p.getSnapshot,n=p.setSnapshot;try{n(e(t._source));var r=iu(g);a.mutableReadLanes|=r&a.pendingLanes}catch(e){n((function(){throw e}))}}))}),[t,r]),or(y,n)&&or(h,t)&&or(d,r)||((e={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:f}).dispatch=c=ko.bind(null,$l,e),s.queue=e,s.baseQueue=null,f=uo(a,t,n),s.memoizedState=s.baseState=f),f}function co(e,t,n){return so(ao(),e,t,n)}function fo(e){var t=ro();return"function"==typeof e&&(e=e()),t.memoizedState=t.baseState=e,e=(e=t.queue={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:e}).dispatch=ko.bind(null,$l,e),[t.memoizedState,e]}function po(e,t,n,r){return e={tag:e,create:t,destroy:n,deps:r,next:null},null===(t=$l.updateQueue)?(t={lastEffect:null},$l.updateQueue=t,t.lastEffect=e.next=e):null===(n=t.lastEffect)?t.lastEffect=e.next=e:(r=n.next,n.next=e,e.next=r,t.lastEffect=e),e}function yo(e){return e={current:e},ro().memoizedState=e}function ho(){return ao().memoizedState}function go(e,t,n,r){var a=ro();$l.flags|=e,a.memoizedState=po(1|t,n,void 0,void 0===r?null:r)}function mo(e,t,n,r){var a=ao();r=void 0===r?null:r;var l=void 0;if(null!==ql){var o=ql.memoizedState;if(l=o.destroy,null!==r&&to(r,o.deps))return void po(t,n,l,r)}$l.flags|=e,a.memoizedState=po(1|t,n,l,r)}function vo(e,t){return go(516,4,e,t)}function bo(e,t){return mo(516,4,e,t)}function Mo(e,t){return mo(4,2,e,t)}function Eo(e,t){return"function"==typeof t?(e=e(),t(e),function(){t(null)}):null!=t?(e=e(),t.current=e,function(){t.current=null}):void 0}function Lo(e,t,n){return n=null!=n?n.concat([e]):null,mo(4,2,Eo.bind(null,t,e),n)}function No(){}function wo(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(n.memoizedState=[e,t],e)}function So(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(e=e(),n.memoizedState=[e,t],e)}function xo(e,t){var n=Qa();Fa(98>n?98:n,(function(){e(!0)})),Fa(97<n?97:n,(function(){var n=Kl.transition;Kl.transition=1;try{e(!1),t()}finally{Kl.transition=n}}))}function ko(e,t,n){var r=ou(),a=iu(e),l={lane:a,action:n,eagerReducer:null,eagerState:null,next:null},o=t.pending;if(null===o?l.next=l:(l.next=o.next,o.next=l),t.pending=l,o=e.alternate,e===$l||null!==o&&o===$l)Jl=Xl=!0;else{if(0===e.lanes&&(null===o||0===o.lanes)&&null!==(o=t.lastRenderedReducer))try{var i=t.lastRenderedState,u=o(i,n);if(l.eagerReducer=o,l.eagerState=u,or(u,i))return}catch(e){}uu(e,a,r)}}var jo={readContext:nl,useCallback:eo,useContext:eo,useEffect:eo,useImperativeHandle:eo,useLayoutEffect:eo,useMemo:eo,useReducer:eo,useRef:eo,useState:eo,useDebugValue:eo,useDeferredValue:eo,useTransition:eo,useMutableSource:eo,useOpaqueIdentifier:eo,unstable_isNewReconciler:!1},To={readContext:nl,useCallback:function(e,t){return ro().memoizedState=[e,void 0===t?null:t],e},useContext:nl,useEffect:vo,useImperativeHandle:function(e,t,n){return n=null!=n?n.concat([e]):null,go(4,2,Eo.bind(null,t,e),n)},useLayoutEffect:function(e,t){return go(4,2,e,t)},useMemo:function(e,t){var n=ro();return t=void 0===t?null:t,e=e(),n.memoizedState=[e,t],e},useReducer:function(e,t,n){var r=ro();return t=void 0!==n?n(t):t,r.memoizedState=r.baseState=t,e=(e=r.queue={pending:null,dispatch:null,lastRenderedReducer:e,lastRenderedState:t}).dispatch=ko.bind(null,$l,e),[r.memoizedState,e]},useRef:yo,useState:fo,useDebugValue:No,useDeferredValue:function(e){var t=fo(e),n=t[0],r=t[1];return vo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=fo(!1),t=e[0];return yo(e=xo.bind(null,e[1])),[e,t]},useMutableSource:function(e,t,n){var r=ro();return r.memoizedState={refs:{getSnapshot:t,setSnapshot:null},source:e,subscribe:n},so(r,e,t,n)},useOpaqueIdentifier:function(){if(Pl){var e=!1,t=function(e){return{$$typeof:A,toString:e,valueOf:e}}((function(){throw e||(e=!0,n("r:"+(Hr++).toString(36))),Error(o(355))})),n=fo(t)[1];return 0==(2&$l.mode)&&($l.flags|=516,po(5,(function(){n("r:"+(Hr++).toString(36))}),void 0,null)),t}return fo(t="r:"+(Hr++).toString(36)),t},unstable_isNewReconciler:!1},Co={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:oo,useRef:ho,useState:function(){return oo(lo)},useDebugValue:No,useDeferredValue:function(e){var t=oo(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=oo(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return oo(lo)[0]},unstable_isNewReconciler:!1},Io={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:io,useRef:ho,useState:function(){return io(lo)},useDebugValue:No,useDeferredValue:function(e){var t=io(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=io(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return io(lo)[0]},unstable_isNewReconciler:!1},Do=E.ReactCurrentOwner,Oo=!1;function zo(e,t,n,r){t.child=null===e?Nl(t,null,n,r):Ll(t,e.child,n,r)}function Ao(e,t,n,r,a){n=n.render;var l=t.ref;return tl(t,a),r=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,r,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function _o(e,t,n,r,a,l){if(null===e){var o=n.type;return"function"!=typeof o||Yu(o)||void 0!==o.defaultProps||null!==n.compare||void 0!==n.defaultProps?((e=Ru(n.type,null,r,t,t.mode,l)).ref=t.ref,e.return=t,t.child=e):(t.tag=15,t.type=o,Po(e,t,o,r,a,l))}return o=e.child,0==(a&l)&&(a=o.memoizedProps,(n=null!==(n=n.compare)?n:ur)(a,r)&&e.ref===t.ref)?Jo(e,t,l):(t.flags|=1,(e=Qu(o,r)).ref=t.ref,e.return=t,t.child=e)}function Po(e,t,n,r,a,l){if(null!==e&&ur(e.memoizedProps,r)&&e.ref===t.ref){if(Oo=!1,0==(l&a))return t.lanes=e.lanes,Jo(e,t,l);0!=(16384&e.flags)&&(Oo=!0)}return Qo(e,t,n,r,l)}function Uo(e,t,n){var r=t.pendingProps,a=r.children,l=null!==e?e.memoizedState:null;if("hidden"===r.mode||"unstable-defer-without-hiding"===r.mode)if(0==(4&t.mode))t.memoizedState={baseLanes:0},gu(0,n);else{if(0==(1073741824&n))return e=null!==l?l.baseLanes|n:n,t.lanes=t.childLanes=1073741824,t.memoizedState={baseLanes:e},gu(0,e),null;t.memoizedState={baseLanes:0},gu(0,null!==l?l.baseLanes:n)}else null!==l?(r=l.baseLanes|n,t.memoizedState=null):r=n,gu(0,r);return zo(e,t,a,n),t.child}function Yo(e,t){var n=t.ref;(null===e&&null!==n||null!==e&&e.ref!==n)&&(t.flags|=128)}function Qo(e,t,n,r,a){var l=pa(n)?fa:sa.current;return l=da(t,l),tl(t,a),n=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,n,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function Ro(e,t,n,r,a){if(pa(n)){var l=!0;ma(t)}else l=!1;if(tl(t,a),null===t.stateNode)null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),hl(t,n,r),ml(t,n,r,a),r=!0;else if(null===e){var o=t.stateNode,i=t.memoizedProps;o.props=i;var u=o.context,s=n.contextType;s="object"==typeof s&&null!==s?nl(s):da(t,s=pa(n)?fa:sa.current);var c=n.getDerivedStateFromProps,f="function"==typeof c||"function"==typeof o.getSnapshotBeforeUpdate;f||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==r||u!==s)&&gl(t,o,r,s),rl=!1;var d=t.memoizedState;o.state=d,sl(t,r,o,a),u=t.memoizedState,i!==r||d!==u||ca.current||rl?("function"==typeof c&&(dl(t,n,c,r),u=t.memoizedState),(i=rl||yl(t,n,i,r,d,u,s))?(f||"function"!=typeof o.UNSAFE_componentWillMount&&"function"!=typeof o.componentWillMount||("function"==typeof o.componentWillMount&&o.componentWillMount(),"function"==typeof o.UNSAFE_componentWillMount&&o.UNSAFE_componentWillMount()),"function"==typeof o.componentDidMount&&(t.flags|=4)):("function"==typeof o.componentDidMount&&(t.flags|=4),t.memoizedProps=r,t.memoizedState=u),o.props=r,o.state=u,o.context=s,r=i):("function"==typeof o.componentDidMount&&(t.flags|=4),r=!1)}else{o=t.stateNode,ll(e,t),i=t.memoizedProps,s=t.type===t.elementType?i:Ka(t.type,i),o.props=s,f=t.pendingProps,d=o.context,u="object"==typeof(u=n.contextType)&&null!==u?nl(u):da(t,u=pa(n)?fa:sa.current);var p=n.getDerivedStateFromProps;(c="function"==typeof p||"function"==typeof o.getSnapshotBeforeUpdate)||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==f||d!==u)&&gl(t,o,r,u),rl=!1,d=t.memoizedState,o.state=d,sl(t,r,o,a);var y=t.memoizedState;i!==f||d!==y||ca.current||rl?("function"==typeof p&&(dl(t,n,p,r),y=t.memoizedState),(s=rl||yl(t,n,s,r,d,y,u))?(c||"function"!=typeof o.UNSAFE_componentWillUpdate&&"function"!=typeof o.componentWillUpdate||("function"==typeof o.componentWillUpdate&&o.componentWillUpdate(r,y,u),"function"==typeof o.UNSAFE_componentWillUpdate&&o.UNSAFE_componentWillUpdate(r,y,u)),"function"==typeof o.componentDidUpdate&&(t.flags|=4),"function"==typeof o.getSnapshotBeforeUpdate&&(t.flags|=256)):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),t.memoizedProps=r,t.memoizedState=y),o.props=r,o.state=y,o.context=u,r=s):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),r=!1)}return Fo(e,t,n,r,l,a)}function Fo(e,t,n,r,a,l){Yo(e,t);var o=0!=(64&t.flags);if(!r&&!o)return a&&va(t,n,!1),Jo(e,t,l);r=t.stateNode,Do.current=t;var i=o&&"function"!=typeof n.getDerivedStateFromError?null:r.render();return t.flags|=1,null!==e&&o?(t.child=Ll(t,e.child,null,l),t.child=Ll(t,null,i,l)):zo(e,t,i,l),t.memoizedState=r.state,a&&va(t,n,!0),t.child}function Vo(e){var t=e.stateNode;t.pendingContext?ha(0,t.pendingContext,t.pendingContext!==t.context):t.context&&ha(0,t.context,!1),Tl(e,t.containerInfo)}var Bo,Wo,Ho,Ko={dehydrated:null,retryLane:0};function Go(e,t,n){var r,a=t.pendingProps,l=Ol.current,o=!1;return(r=0!=(64&t.flags))||(r=(null===e||null!==e.memoizedState)&&0!=(2&l)),r?(o=!0,t.flags&=-65):null!==e&&null===e.memoizedState||void 0===a.fallback||!0===a.unstable_avoidThisFallback||(l|=1),ia(Ol,1&l),null===e?(void 0!==a.fallback&&Ql(t),e=a.children,l=a.fallback,o?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,e):"number"==typeof a.unstable_expectedLoadTime?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,t.lanes=33554432,e):((n=Vu({mode:"visible",children:e},t.mode,n,null)).return=t,t.child=n)):(e.memoizedState,o?(a=function(e,t,n,r,a){var l=t.mode,o=e.child;e=o.sibling;var i={mode:"hidden",children:n};return 0==(2&l)&&t.child!==o?((n=t.child).childLanes=0,n.pendingProps=i,null!==(o=n.lastEffect)?(t.firstEffect=n.firstEffect,t.lastEffect=o,o.nextEffect=null):t.firstEffect=t.lastEffect=null):n=Qu(o,i),null!==e?r=Qu(e,r):(r=Fu(r,l,a,null)).flags|=2,r.return=t,n.return=t,n.sibling=r,t.child=n,r}(e,t,a.children,a.fallback,n),o=t.child,l=e.child.memoizedState,o.memoizedState=null===l?{baseLanes:n}:{baseLanes:l.baseLanes|n},o.childLanes=e.childLanes&~n,t.memoizedState=Ko,a):(n=function(e,t,n,r){var a=e.child;return e=a.sibling,n=Qu(a,{mode:"visible",children:n}),0==(2&t.mode)&&(n.lanes=r),n.return=t,n.sibling=null,null!==e&&(e.nextEffect=null,e.flags=8,t.firstEffect=t.lastEffect=e),t.child=n}(e,t,a.children,n),t.memoizedState=null,n))}function $o(e,t,n,r){var a=e.mode,l=e.child;return t={mode:"hidden",children:t},0==(2&a)&&null!==l?(l.childLanes=0,l.pendingProps=t):l=Vu(t,a,0,null),n=Fu(n,a,r,null),l.return=e,n.return=e,l.sibling=n,e.child=l,n}function qo(e,t){e.lanes|=t;var n=e.alternate;null!==n&&(n.lanes|=t),el(e.return,t)}function Zo(e,t,n,r,a,l){var o=e.memoizedState;null===o?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:r,tail:n,tailMode:a,lastEffect:l}:(o.isBackwards=t,o.rendering=null,o.renderingStartTime=0,o.last=r,o.tail=n,o.tailMode=a,o.lastEffect=l)}function Xo(e,t,n){var r=t.pendingProps,a=r.revealOrder,l=r.tail;if(zo(e,t,r.children,n),0!=(2&(r=Ol.current)))r=1&r|2,t.flags|=64;else{if(null!==e&&0!=(64&e.flags))e:for(e=t.child;null!==e;){if(13===e.tag)null!==e.memoizedState&&qo(e,n);else if(19===e.tag)qo(e,n);else if(null!==e.child){e.child.return=e,e=e.child;continue}if(e===t)break e;for(;null===e.sibling;){if(null===e.return||e.return===t)break e;e=e.return}e.sibling.return=e.return,e=e.sibling}r&=1}if(ia(Ol,r),0==(2&t.mode))t.memoizedState=null;else switch(a){case"forwards":for(n=t.child,a=null;null!==n;)null!==(e=n.alternate)&&null===zl(e)&&(a=n),n=n.sibling;null===(n=a)?(a=t.child,t.child=null):(a=n.sibling,n.sibling=null),Zo(t,!1,a,n,l,t.lastEffect);break;case"backwards":for(n=null,a=t.child,t.child=null;null!==a;){if(null!==(e=a.alternate)&&null===zl(e)){t.child=a;break}e=a.sibling,a.sibling=n,n=a,a=e}Zo(t,!0,n,null,l,t.lastEffect);break;case"together":Zo(t,!1,null,null,void 0,t.lastEffect);break;default:t.memoizedState=null}return t.child}function Jo(e,t,n){if(null!==e&&(t.dependencies=e.dependencies),Ai|=t.lanes,0!=(n&t.childLanes)){if(null!==e&&t.child!==e.child)throw Error(o(153));if(null!==t.child){for(n=Qu(e=t.child,e.pendingProps),t.child=n,n.return=t;null!==e.sibling;)e=e.sibling,(n=n.sibling=Qu(e,e.pendingProps)).return=t;n.sibling=null}return t.child}return null}function ei(e,t){if(!Pl)switch(e.tailMode){case"hidden":t=e.tail;for(var n=null;null!==t;)null!==t.alternate&&(n=t),t=t.sibling;null===n?e.tail=null:n.sibling=null;break;case"collapsed":n=e.tail;for(var r=null;null!==n;)null!==n.alternate&&(r=n),n=n.sibling;null===r?t||null===e.tail?e.tail=null:e.tail.sibling=null:r.sibling=null}}function ti(e,t,n){var r=t.pendingProps;switch(t.tag){case 2:case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return null;case 1:return pa(t.type)&&ya(),null;case 3:return Cl(),oa(ca),oa(sa),Wl(),(r=t.stateNode).pendingContext&&(r.context=r.pendingContext,r.pendingContext=null),null!==e&&null!==e.child||(Fl(t)?t.flags|=4:r.hydrate||(t.flags|=256)),null;case 5:Dl(t);var l=jl(kl.current);if(n=t.type,null!==e&&null!=t.stateNode)Wo(e,t,n,r),e.ref!==t.ref&&(t.flags|=128);else{if(!r){if(null===t.stateNode)throw Error(o(166));return null}if(e=jl(Sl.current),Fl(t)){r=t.stateNode,n=t.type;var i=t.memoizedProps;switch(r[Gr]=t,r[$r]=i,n){case"dialog":xr("cancel",r),xr("close",r);break;case"iframe":case"object":case"embed":xr("load",r);break;case"video":case"audio":for(e=0;e<Lr.length;e++)xr(Lr[e],r);break;case"source":xr("error",r);break;case"img":case"image":case"link":xr("error",r),xr("load",r);break;case"details":xr("toggle",r);break;case"input":ee(r,i),xr("invalid",r);break;case"select":r._wrapperState={wasMultiple:!!i.multiple},xr("invalid",r);break;case"textarea":ue(r,i),xr("invalid",r)}for(var s in Ne(n,i),e=null,i)i.hasOwnProperty(s)&&(l=i[s],"children"===s?"string"==typeof l?r.textContent!==l&&(e=["children",l]):"number"==typeof l&&r.textContent!==""+l&&(e=["children",""+l]):u.hasOwnProperty(s)&&null!=l&&"onScroll"===s&&xr("scroll",r));switch(n){case"input":q(r),re(r,i,!0);break;case"textarea":q(r),ce(r);break;case"select":case"option":break;default:"function"==typeof i.onClick&&(r.onclick=_r)}r=e,t.updateQueue=r,null!==r&&(t.flags|=4)}else{switch(s=9===l.nodeType?l:l.ownerDocument,e===fe&&(e=de(n)),e===fe?"script"===n?((e=s.createElement("div")).innerHTML="<script><\/script>",e=e.removeChild(e.firstChild)):"string"==typeof r.is?e=s.createElement(n,{is:r.is}):(e=s.createElement(n),"select"===n&&(s=e,r.multiple?s.multiple=!0:r.size&&(s.size=r.size))):e=s.createElementNS(e,n),e[Gr]=t,e[$r]=r,Bo(e,t),t.stateNode=e,s=we(n,r),n){case"dialog":xr("cancel",e),xr("close",e),l=r;break;case"iframe":case"object":case"embed":xr("load",e),l=r;break;case"video":case"audio":for(l=0;l<Lr.length;l++)xr(Lr[l],e);l=r;break;case"source":xr("error",e),l=r;break;case"img":case"image":case"link":xr("error",e),xr("load",e),l=r;break;case"details":xr("toggle",e),l=r;break;case"input":ee(e,r),l=J(e,r),xr("invalid",e);break;case"option":l=le(e,r);break;case"select":e._wrapperState={wasMultiple:!!r.multiple},l=a({},r,{value:void 0}),xr("invalid",e);break;case"textarea":ue(e,r),l=ie(e,r),xr("invalid",e);break;default:l=r}Ne(n,l);var c=l;for(i in c)if(c.hasOwnProperty(i)){var f=c[i];"style"===i?Ee(e,f):"dangerouslySetInnerHTML"===i?null!=(f=f?f.__html:void 0)&&ge(e,f):"children"===i?"string"==typeof f?("textarea"!==n||""!==f)&&me(e,f):"number"==typeof f&&me(e,""+f):"suppressContentEditableWarning"!==i&&"suppressHydrationWarning"!==i&&"autoFocus"!==i&&(u.hasOwnProperty(i)?null!=f&&"onScroll"===i&&xr("scroll",e):null!=f&&M(e,i,f,s))}switch(n){case"input":q(e),re(e,r,!1);break;case"textarea":q(e),ce(e);break;case"option":null!=r.value&&e.setAttribute("value",""+G(r.value));break;case"select":e.multiple=!!r.multiple,null!=(i=r.value)?oe(e,!!r.multiple,i,!1):null!=r.defaultValue&&oe(e,!!r.multiple,r.defaultValue,!0);break;default:"function"==typeof l.onClick&&(e.onclick=_r)}Yr(n,r)&&(t.flags|=4)}null!==t.ref&&(t.flags|=128)}return null;case 6:if(e&&null!=t.stateNode)Ho(0,t,e.memoizedProps,r);else{if("string"!=typeof r&&null===t.stateNode)throw Error(o(166));n=jl(kl.current),jl(Sl.current),Fl(t)?(r=t.stateNode,n=t.memoizedProps,r[Gr]=t,r.nodeValue!==n&&(t.flags|=4)):((r=(9===n.nodeType?n:n.ownerDocument).createTextNode(r))[Gr]=t,t.stateNode=r)}return null;case 13:return oa(Ol),r=t.memoizedState,0!=(64&t.flags)?(t.lanes=n,t):(r=null!==r,n=!1,null===e?void 0!==t.memoizedProps.fallback&&Fl(t):n=null!==e.memoizedState,r&&!n&&0!=(2&t.mode)&&(null===e&&!0!==t.memoizedProps.unstable_avoidThisFallback||0!=(1&Ol.current)?0===Di&&(Di=3):(0!==Di&&3!==Di||(Di=4),null===ki||0==(134217727&Ai)&&0==(134217727&_i)||du(ki,Ti))),(r||n)&&(t.flags|=4),null);case 4:return Cl(),null===e&&jr(t.stateNode.containerInfo),null;case 10:return Ja(t),null;case 17:return pa(t.type)&&ya(),null;case 19:if(oa(Ol),null===(r=t.memoizedState))return null;if(i=0!=(64&t.flags),null===(s=r.rendering))if(i)ei(r,!1);else{if(0!==Di||null!==e&&0!=(64&e.flags))for(e=t.child;null!==e;){if(null!==(s=zl(e))){for(t.flags|=64,ei(r,!1),null!==(i=s.updateQueue)&&(t.updateQueue=i,t.flags|=4),null===r.lastEffect&&(t.firstEffect=null),t.lastEffect=r.lastEffect,r=n,n=t.child;null!==n;)e=r,(i=n).flags&=2,i.nextEffect=null,i.firstEffect=null,i.lastEffect=null,null===(s=i.alternate)?(i.childLanes=0,i.lanes=e,i.child=null,i.memoizedProps=null,i.memoizedState=null,i.updateQueue=null,i.dependencies=null,i.stateNode=null):(i.childLanes=s.childLanes,i.lanes=s.lanes,i.child=s.child,i.memoizedProps=s.memoizedProps,i.memoizedState=s.memoizedState,i.updateQueue=s.updateQueue,i.type=s.type,e=s.dependencies,i.dependencies=null===e?null:{lanes:e.lanes,firstContext:e.firstContext}),n=n.sibling;return ia(Ol,1&Ol.current|2),t.child}e=e.sibling}null!==r.tail&&Ya()>Qi&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432)}else{if(!i)if(null!==(e=zl(s))){if(t.flags|=64,i=!0,null!==(n=e.updateQueue)&&(t.updateQueue=n,t.flags|=4),ei(r,!0),null===r.tail&&"hidden"===r.tailMode&&!s.alternate&&!Pl)return null!==(t=t.lastEffect=r.lastEffect)&&(t.nextEffect=null),null}else 2*Ya()-r.renderingStartTime>Qi&&1073741824!==n&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432);r.isBackwards?(s.sibling=t.child,t.child=s):(null!==(n=r.last)?n.sibling=s:t.child=s,r.last=s)}return null!==r.tail?(n=r.tail,r.rendering=n,r.tail=n.sibling,r.lastEffect=t.lastEffect,r.renderingStartTime=Ya(),n.sibling=null,t=Ol.current,ia(Ol,i?1&t|2:1&t),n):null;case 23:case 24:return mu(),null!==e&&null!==e.memoizedState!=(null!==t.memoizedState)&&"unstable-defer-without-hiding"!==r.mode&&(t.flags|=4),null}throw Error(o(156,t.tag))}function ni(e){switch(e.tag){case 1:pa(e.type)&&ya();var t=e.flags;return 4096&t?(e.flags=-4097&t|64,e):null;case 3:if(Cl(),oa(ca),oa(sa),Wl(),0!=(64&(t=e.flags)))throw Error(o(285));return e.flags=-4097&t|64,e;case 5:return Dl(e),null;case 13:return oa(Ol),4096&(t=e.flags)?(e.flags=-4097&t|64,e):null;case 19:return oa(Ol),null;case 4:return Cl(),null;case 10:return Ja(e),null;case 23:case 24:return mu(),null;default:return null}}function ri(e,t){try{var n="",r=t;do{n+=H(r),r=r.return}while(r);var a=n}catch(e){a="\nError generating stack: "+e.message+"\n"+e.stack}return{value:e,source:t,stack:a}}function ai(e,t){try{console.error(t.value)}catch(e){setTimeout((function(){throw e}))}}Bo=function(e,t){for(var n=t.child;null!==n;){if(5===n.tag||6===n.tag)e.appendChild(n.stateNode);else if(4!==n.tag&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===t)break;for(;null===n.sibling;){if(null===n.return||n.return===t)return;n=n.return}n.sibling.return=n.return,n=n.sibling}},Wo=function(e,t,n,r){var l=e.memoizedProps;if(l!==r){e=t.stateNode,jl(Sl.current);var o,i=null;switch(n){case"input":l=J(e,l),r=J(e,r),i=[];break;case"option":l=le(e,l),r=le(e,r),i=[];break;case"select":l=a({},l,{value:void 0}),r=a({},r,{value:void 0}),i=[];break;case"textarea":l=ie(e,l),r=ie(e,r),i=[];break;default:"function"!=typeof l.onClick&&"function"==typeof r.onClick&&(e.onclick=_r)}for(f in Ne(n,r),n=null,l)if(!r.hasOwnProperty(f)&&l.hasOwnProperty(f)&&null!=l[f])if("style"===f){var s=l[f];for(o in s)s.hasOwnProperty(o)&&(n||(n={}),n[o]="")}else"dangerouslySetInnerHTML"!==f&&"children"!==f&&"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&"autoFocus"!==f&&(u.hasOwnProperty(f)?i||(i=[]):(i=i||[]).push(f,null));for(f in r){var c=r[f];if(s=null!=l?l[f]:void 0,r.hasOwnProperty(f)&&c!==s&&(null!=c||null!=s))if("style"===f)if(s){for(o in s)!s.hasOwnProperty(o)||c&&c.hasOwnProperty(o)||(n||(n={}),n[o]="");for(o in c)c.hasOwnProperty(o)&&s[o]!==c[o]&&(n||(n={}),n[o]=c[o])}else n||(i||(i=[]),i.push(f,n)),n=c;else"dangerouslySetInnerHTML"===f?(c=c?c.__html:void 0,s=s?s.__html:void 0,null!=c&&s!==c&&(i=i||[]).push(f,c)):"children"===f?"string"!=typeof c&&"number"!=typeof c||(i=i||[]).push(f,""+c):"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&(u.hasOwnProperty(f)?(null!=c&&"onScroll"===f&&xr("scroll",e),i||s===c||(i=[])):"object"==typeof c&&null!==c&&c.$$typeof===A?c.toString():(i=i||[]).push(f,c))}n&&(i=i||[]).push("style",n);var f=i;(t.updateQueue=f)&&(t.flags|=4)}},Ho=function(e,t,n,r){n!==r&&(t.flags|=4)};var li="function"==typeof WeakMap?WeakMap:Map;function oi(e,t,n){(n=ol(-1,n)).tag=3,n.payload={element:null};var r=t.value;return n.callback=function(){Bi||(Bi=!0,Wi=r),ai(0,t)},n}function ii(e,t,n){(n=ol(-1,n)).tag=3;var r=e.type.getDerivedStateFromError;if("function"==typeof r){var a=t.value;n.payload=function(){return ai(0,t),r(a)}}var l=e.stateNode;return null!==l&&"function"==typeof l.componentDidCatch&&(n.callback=function(){"function"!=typeof r&&(null===Hi?Hi=new Set([this]):Hi.add(this),ai(0,t));var e=t.stack;this.componentDidCatch(t.value,{componentStack:null!==e?e:""})}),n}var ui="function"==typeof WeakSet?WeakSet:Set;function si(e){var t=e.ref;if(null!==t)if("function"==typeof t)try{t(null)}catch(t){zu(e,t)}else t.current=null}function ci(e,t){switch(t.tag){case 0:case 11:case 15:case 22:return;case 1:if(256&t.flags&&null!==e){var n=e.memoizedProps,r=e.memoizedState;t=(e=t.stateNode).getSnapshotBeforeUpdate(t.elementType===t.type?n:Ka(t.type,n),r),e.__reactInternalSnapshotBeforeUpdate=t}return;case 3:return void(256&t.flags&&Vr(t.stateNode.containerInfo));case 5:case 6:case 4:case 17:return}throw Error(o(163))}function fi(e,t,n){switch(n.tag){case 0:case 11:case 15:case 22:if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{if(3==(3&e.tag)){var r=e.create;e.destroy=r()}e=e.next}while(e!==t)}if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{var a=e;r=a.next,0!=(4&(a=a.tag))&&0!=(1&a)&&(Iu(n,e),Cu(n,e)),e=r}while(e!==t)}return;case 1:return e=n.stateNode,4&n.flags&&(null===t?e.componentDidMount():(r=n.elementType===n.type?t.memoizedProps:Ka(n.type,t.memoizedProps),e.componentDidUpdate(r,t.memoizedState,e.__reactInternalSnapshotBeforeUpdate))),void(null!==(t=n.updateQueue)&&cl(n,t,e));case 3:if(null!==(t=n.updateQueue)){if(e=null,null!==n.child)switch(n.child.tag){case 5:e=n.child.stateNode;break;case 1:e=n.child.stateNode}cl(n,t,e)}return;case 5:return e=n.stateNode,void(null===t&&4&n.flags&&Yr(n.type,n.memoizedProps)&&e.focus());case 6:case 4:case 12:return;case 13:return void(null===n.memoizedState&&(n=n.alternate,null!==n&&(n=n.memoizedState,null!==n&&(n=n.dehydrated,null!==n&&Et(n)))));case 19:case 17:case 20:case 21:case 23:case 24:return}throw Error(o(163))}function di(e,t){for(var n=e;;){if(5===n.tag){var r=n.stateNode;if(t)"function"==typeof(r=r.style).setProperty?r.setProperty("display","none","important"):r.display="none";else{r=n.stateNode;var a=n.memoizedProps.style;a=null!=a&&a.hasOwnProperty("display")?a.display:null,r.style.display=Me("display",a)}}else if(6===n.tag)n.stateNode.nodeValue=t?"":n.memoizedProps;else if((23!==n.tag&&24!==n.tag||null===n.memoizedState||n===e)&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===e)break;for(;null===n.sibling;){if(null===n.return||n.return===e)return;n=n.return}n.sibling.return=n.return,n=n.sibling}}function pi(e,t){if(Ma&&"function"==typeof Ma.onCommitFiberUnmount)try{Ma.onCommitFiberUnmount(ba,t)}catch(e){}switch(t.tag){case 0:case 11:case 14:case 15:case 22:if(null!==(e=t.updateQueue)&&null!==(e=e.lastEffect)){var n=e=e.next;do{var r=n,a=r.destroy;if(r=r.tag,void 0!==a)if(0!=(4&r))Iu(t,n);else{r=t;try{a()}catch(e){zu(r,e)}}n=n.next}while(n!==e)}break;case 1:if(si(t),"function"==typeof(e=t.stateNode).componentWillUnmount)try{e.props=t.memoizedProps,e.state=t.memoizedState,e.componentWillUnmount()}catch(e){zu(t,e)}break;case 5:si(t);break;case 4:bi(e,t)}}function yi(e){e.alternate=null,e.child=null,e.dependencies=null,e.firstEffect=null,e.lastEffect=null,e.memoizedProps=null,e.memoizedState=null,e.pendingProps=null,e.return=null,e.updateQueue=null}function hi(e){return 5===e.tag||3===e.tag||4===e.tag}function gi(e){e:{for(var t=e.return;null!==t;){if(hi(t))break e;t=t.return}throw Error(o(160))}var n=t;switch(t=n.stateNode,n.tag){case 5:var r=!1;break;case 3:case 4:t=t.containerInfo,r=!0;break;default:throw Error(o(161))}16&n.flags&&(me(t,""),n.flags&=-17);e:t:for(n=e;;){for(;null===n.sibling;){if(null===n.return||hi(n.return)){n=null;break e}n=n.return}for(n.sibling.return=n.return,n=n.sibling;5!==n.tag&&6!==n.tag&&18!==n.tag;){if(2&n.flags)continue t;if(null===n.child||4===n.tag)continue t;n.child.return=n,n=n.child}if(!(2&n.flags)){n=n.stateNode;break e}}r?mi(e,n,t):vi(e,n,t)}function mi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?8===n.nodeType?n.parentNode.insertBefore(e,t):n.insertBefore(e,t):(8===n.nodeType?(t=n.parentNode).insertBefore(e,n):(t=n).appendChild(e),null!=(n=n._reactRootContainer)||null!==t.onclick||(t.onclick=_r));else if(4!==r&&null!==(e=e.child))for(mi(e,t,n),e=e.sibling;null!==e;)mi(e,t,n),e=e.sibling}function vi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?n.insertBefore(e,t):n.appendChild(e);else if(4!==r&&null!==(e=e.child))for(vi(e,t,n),e=e.sibling;null!==e;)vi(e,t,n),e=e.sibling}function bi(e,t){for(var n,r,a=t,l=!1;;){if(!l){l=a.return;e:for(;;){if(null===l)throw Error(o(160));switch(n=l.stateNode,l.tag){case 5:r=!1;break e;case 3:case 4:n=n.containerInfo,r=!0;break e}l=l.return}l=!0}if(5===a.tag||6===a.tag){e:for(var i=e,u=a,s=u;;)if(pi(i,s),null!==s.child&&4!==s.tag)s.child.return=s,s=s.child;else{if(s===u)break e;for(;null===s.sibling;){if(null===s.return||s.return===u)break e;s=s.return}s.sibling.return=s.return,s=s.sibling}r?(i=n,u=a.stateNode,8===i.nodeType?i.parentNode.removeChild(u):i.removeChild(u)):n.removeChild(a.stateNode)}else if(4===a.tag){if(null!==a.child){n=a.stateNode.containerInfo,r=!0,a.child.return=a,a=a.child;continue}}else if(pi(e,a),null!==a.child){a.child.return=a,a=a.child;continue}if(a===t)break;for(;null===a.sibling;){if(null===a.return||a.return===t)return;4===(a=a.return).tag&&(l=!1)}a.sibling.return=a.return,a=a.sibling}}function Mi(e,t){switch(t.tag){case 0:case 11:case 14:case 15:case 22:var n=t.updateQueue;if(null!==(n=null!==n?n.lastEffect:null)){var r=n=n.next;do{3==(3&r.tag)&&(e=r.destroy,r.destroy=void 0,void 0!==e&&e()),r=r.next}while(r!==n)}return;case 1:return;case 5:if(null!=(n=t.stateNode)){r=t.memoizedProps;var a=null!==e?e.memoizedProps:r;e=t.type;var l=t.updateQueue;if(t.updateQueue=null,null!==l){for(n[$r]=r,"input"===e&&"radio"===r.type&&null!=r.name&&te(n,r),we(e,a),t=we(e,r),a=0;a<l.length;a+=2){var i=l[a],u=l[a+1];"style"===i?Ee(n,u):"dangerouslySetInnerHTML"===i?ge(n,u):"children"===i?me(n,u):M(n,i,u,t)}switch(e){case"input":ne(n,r);break;case"textarea":se(n,r);break;case"select":e=n._wrapperState.wasMultiple,n._wrapperState.wasMultiple=!!r.multiple,null!=(l=r.value)?oe(n,!!r.multiple,l,!1):e!==!!r.multiple&&(null!=r.defaultValue?oe(n,!!r.multiple,r.defaultValue,!0):oe(n,!!r.multiple,r.multiple?[]:"",!1))}}}return;case 6:if(null===t.stateNode)throw Error(o(162));return void(t.stateNode.nodeValue=t.memoizedProps);case 3:return void((n=t.stateNode).hydrate&&(n.hydrate=!1,Et(n.containerInfo)));case 12:return;case 13:return null!==t.memoizedState&&(Yi=Ya(),di(t.child,!0)),void Ei(t);case 19:return void Ei(t);case 17:return;case 23:case 24:return void di(t,null!==t.memoizedState)}throw Error(o(163))}function Ei(e){var t=e.updateQueue;if(null!==t){e.updateQueue=null;var n=e.stateNode;null===n&&(n=e.stateNode=new ui),t.forEach((function(t){var r=_u.bind(null,e,t);n.has(t)||(n.add(t),t.then(r,r))}))}}function Li(e,t){return null!==e&&(null===(e=e.memoizedState)||null!==e.dehydrated)&&null!==(t=t.memoizedState)&&null===t.dehydrated}var Ni=Math.ceil,wi=E.ReactCurrentDispatcher,Si=E.ReactCurrentOwner,xi=0,ki=null,ji=null,Ti=0,Ci=0,Ii=la(0),Di=0,Oi=null,zi=0,Ai=0,_i=0,Pi=0,Ui=null,Yi=0,Qi=1/0;function Ri(){Qi=Ya()+500}var Fi,Vi=null,Bi=!1,Wi=null,Hi=null,Ki=!1,Gi=null,$i=90,qi=[],Zi=[],Xi=null,Ji=0,eu=null,tu=-1,nu=0,ru=0,au=null,lu=!1;function ou(){return 0!=(48&xi)?Ya():-1!==tu?tu:tu=Ya()}function iu(e){if(0==(2&(e=e.mode)))return 1;if(0==(4&e))return 99===Qa()?1:2;if(0===nu&&(nu=zi),0!==Ha.transition){0!==ru&&(ru=null!==Ui?Ui.pendingLanes:0),e=nu;var t=4186112&~ru;return 0==(t&=-t)&&0==(t=(e=4186112&~e)&-e)&&(t=8192),t}return e=Qa(),e=Yt(0!=(4&xi)&&98===e?12:e=function(e){switch(e){case 99:return 15;case 98:return 10;case 97:case 96:return 8;case 95:return 2;default:return 0}}(e),nu)}function uu(e,t,n){if(50<Ji)throw Ji=0,eu=null,Error(o(185));if(null===(e=su(e,t)))return null;Ft(e,t,n),e===ki&&(_i|=t,4===Di&&du(e,Ti));var r=Qa();1===t?0!=(8&xi)&&0==(48&xi)?pu(e):(cu(e,n),0===xi&&(Ri(),Ba())):(0==(4&xi)||98!==r&&99!==r||(null===Xi?Xi=new Set([e]):Xi.add(e)),cu(e,n)),Ui=e}function su(e,t){e.lanes|=t;var n=e.alternate;for(null!==n&&(n.lanes|=t),n=e,e=e.return;null!==e;)e.childLanes|=t,null!==(n=e.alternate)&&(n.childLanes|=t),n=e,e=e.return;return 3===n.tag?n.stateNode:null}function cu(e,t){for(var n=e.callbackNode,r=e.suspendedLanes,a=e.pingedLanes,l=e.expirationTimes,i=e.pendingLanes;0<i;){var u=31-Vt(i),s=1<<u,c=l[u];if(-1===c){if(0==(s&r)||0!=(s&a)){c=t,_t(s);var f=At;l[u]=10<=f?c+250:6<=f?c+5e3:-1}}else c<=t&&(e.expiredLanes|=s);i&=~s}if(r=Pt(e,e===ki?Ti:0),t=At,0===r)null!==n&&(n!==Oa&&Na(n),e.callbackNode=null,e.callbackPriority=0);else{if(null!==n){if(e.callbackPriority===t)return;n!==Oa&&Na(n)}15===t?(n=pu.bind(null,e),null===Aa?(Aa=[n],_a=La(ja,Wa)):Aa.push(n),n=Oa):n=14===t?Va(99,pu.bind(null,e)):Va(n=function(e){switch(e){case 15:case 14:return 99;case 13:case 12:case 11:case 10:return 98;case 9:case 8:case 7:case 6:case 4:case 5:return 97;case 3:case 2:case 1:return 95;case 0:return 90;default:throw Error(o(358,e))}}(t),fu.bind(null,e)),e.callbackPriority=t,e.callbackNode=n}}function fu(e){if(tu=-1,ru=nu=0,0!=(48&xi))throw Error(o(327));var t=e.callbackNode;if(Tu()&&e.callbackNode!==t)return null;var n=Pt(e,e===ki?Ti:0);if(0===n)return null;var r=n,a=xi;xi|=16;var l=Mu();for(ki===e&&Ti===r||(Ri(),vu(e,r));;)try{Nu();break}catch(t){bu(e,t)}if(Xa(),wi.current=l,xi=a,null!==ji?r=0:(ki=null,Ti=0,r=Di),0!=(zi&_i))vu(e,0);else if(0!==r){if(2===r&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(n=Ut(e))&&(r=Eu(e,n))),1===r)throw t=Oi,vu(e,0),du(e,n),cu(e,Ya()),t;switch(e.finishedWork=e.current.alternate,e.finishedLanes=n,r){case 0:case 1:throw Error(o(345));case 2:xu(e);break;case 3:if(du(e,n),(62914560&n)===n&&10<(r=Yi+500-Ya())){if(0!==Pt(e,0))break;if(((a=e.suspendedLanes)&n)!==n){ou(),e.pingedLanes|=e.suspendedLanes&a;break}e.timeoutHandle=Rr(xu.bind(null,e),r);break}xu(e);break;case 4:if(du(e,n),(4186112&n)===n)break;for(r=e.eventTimes,a=-1;0<n;){var i=31-Vt(n);l=1<<i,(i=r[i])>a&&(a=i),n&=~l}if(n=a,10<(n=(120>(n=Ya()-n)?120:480>n?480:1080>n?1080:1920>n?1920:3e3>n?3e3:4320>n?4320:1960*Ni(n/1960))-n)){e.timeoutHandle=Rr(xu.bind(null,e),n);break}xu(e);break;case 5:xu(e);break;default:throw Error(o(329))}}return cu(e,Ya()),e.callbackNode===t?fu.bind(null,e):null}function du(e,t){for(t&=~Pi,t&=~_i,e.suspendedLanes|=t,e.pingedLanes&=~t,e=e.expirationTimes;0<t;){var n=31-Vt(t),r=1<<n;e[n]=-1,t&=~r}}function pu(e){if(0!=(48&xi))throw Error(o(327));if(Tu(),e===ki&&0!=(e.expiredLanes&Ti)){var t=Ti,n=Eu(e,t);0!=(zi&_i)&&(n=Eu(e,t=Pt(e,t)))}else n=Eu(e,t=Pt(e,0));if(0!==e.tag&&2===n&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(t=Ut(e))&&(n=Eu(e,t))),1===n)throw n=Oi,vu(e,0),du(e,t),cu(e,Ya()),n;return e.finishedWork=e.current.alternate,e.finishedLanes=t,xu(e),cu(e,Ya()),null}function yu(e,t){var n=xi;xi|=1;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function hu(e,t){var n=xi;xi&=-2,xi|=8;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function gu(e,t){ia(Ii,Ci),Ci|=t,zi|=t}function mu(){Ci=Ii.current,oa(Ii)}function vu(e,t){e.finishedWork=null,e.finishedLanes=0;var n=e.timeoutHandle;if(-1!==n&&(e.timeoutHandle=-1,Fr(n)),null!==ji)for(n=ji.return;null!==n;){var r=n;switch(r.tag){case 1:null!=(r=r.type.childContextTypes)&&ya();break;case 3:Cl(),oa(ca),oa(sa),Wl();break;case 5:Dl(r);break;case 4:Cl();break;case 13:case 19:oa(Ol);break;case 10:Ja(r);break;case 23:case 24:mu()}n=n.return}ki=e,ji=Qu(e.current,null),Ti=Ci=zi=t,Di=0,Oi=null,Pi=_i=Ai=0}function bu(e,t){for(;;){var n=ji;try{if(Xa(),Hl.current=jo,Xl){for(var r=$l.memoizedState;null!==r;){var a=r.queue;null!==a&&(a.pending=null),r=r.next}Xl=!1}if(Gl=0,Zl=ql=$l=null,Jl=!1,Si.current=null,null===n||null===n.return){Di=1,Oi=t,ji=null;break}e:{var l=e,o=n.return,i=n,u=t;if(t=Ti,i.flags|=2048,i.firstEffect=i.lastEffect=null,null!==u&&"object"==typeof u&&"function"==typeof u.then){var s=u;if(0==(2&i.mode)){var c=i.alternate;c?(i.updateQueue=c.updateQueue,i.memoizedState=c.memoizedState,i.lanes=c.lanes):(i.updateQueue=null,i.memoizedState=null)}var f=0!=(1&Ol.current),d=o;do{var p;if(p=13===d.tag){var y=d.memoizedState;if(null!==y)p=null!==y.dehydrated;else{var h=d.memoizedProps;p=void 0!==h.fallback&&(!0!==h.unstable_avoidThisFallback||!f)}}if(p){var g=d.updateQueue;if(null===g){var m=new Set;m.add(s),d.updateQueue=m}else g.add(s);if(0==(2&d.mode)){if(d.flags|=64,i.flags|=16384,i.flags&=-2981,1===i.tag)if(null===i.alternate)i.tag=17;else{var v=ol(-1,1);v.tag=2,il(i,v)}i.lanes|=1;break e}u=void 0,i=t;var b=l.pingCache;if(null===b?(b=l.pingCache=new li,u=new Set,b.set(s,u)):void 0===(u=b.get(s))&&(u=new Set,b.set(s,u)),!u.has(i)){u.add(i);var M=Au.bind(null,l,s,i);s.then(M,M)}d.flags|=4096,d.lanes=t;break e}d=d.return}while(null!==d);u=Error((K(i.type)||"A React component")+" suspended while rendering, but no fallback UI was specified.\n\nAdd a <Suspense fallback=...> component higher in the tree to provide a loading indicator or placeholder to display.")}5!==Di&&(Di=2),u=ri(u,i),d=o;do{switch(d.tag){case 3:l=u,d.flags|=4096,t&=-t,d.lanes|=t,ul(d,oi(0,l,t));break e;case 1:l=u;var E=d.type,L=d.stateNode;if(0==(64&d.flags)&&("function"==typeof E.getDerivedStateFromError||null!==L&&"function"==typeof L.componentDidCatch&&(null===Hi||!Hi.has(L)))){d.flags|=4096,t&=-t,d.lanes|=t,ul(d,ii(d,l,t));break e}}d=d.return}while(null!==d)}Su(n)}catch(e){t=e,ji===n&&null!==n&&(ji=n=n.return);continue}break}}function Mu(){var e=wi.current;return wi.current=jo,null===e?jo:e}function Eu(e,t){var n=xi;xi|=16;var r=Mu();for(ki===e&&Ti===t||vu(e,t);;)try{Lu();break}catch(t){bu(e,t)}if(Xa(),xi=n,wi.current=r,null!==ji)throw Error(o(261));return ki=null,Ti=0,Di}function Lu(){for(;null!==ji;)wu(ji)}function Nu(){for(;null!==ji&&!wa();)wu(ji)}function wu(e){var t=Fi(e.alternate,e,Ci);e.memoizedProps=e.pendingProps,null===t?Su(e):ji=t,Si.current=null}function Su(e){var t=e;do{var n=t.alternate;if(e=t.return,0==(2048&t.flags)){if(null!==(n=ti(n,t,Ci)))return void(ji=n);if(24!==(n=t).tag&&23!==n.tag||null===n.memoizedState||0!=(1073741824&Ci)||0==(4&n.mode)){for(var r=0,a=n.child;null!==a;)r|=a.lanes|a.childLanes,a=a.sibling;n.childLanes=r}null!==e&&0==(2048&e.flags)&&(null===e.firstEffect&&(e.firstEffect=t.firstEffect),null!==t.lastEffect&&(null!==e.lastEffect&&(e.lastEffect.nextEffect=t.firstEffect),e.lastEffect=t.lastEffect),1<t.flags&&(null!==e.lastEffect?e.lastEffect.nextEffect=t:e.firstEffect=t,e.lastEffect=t))}else{if(null!==(n=ni(t)))return n.flags&=2047,void(ji=n);null!==e&&(e.firstEffect=e.lastEffect=null,e.flags|=2048)}if(null!==(t=t.sibling))return void(ji=t);ji=t=e}while(null!==t);0===Di&&(Di=5)}function xu(e){var t=Qa();return Fa(99,ku.bind(null,e,t)),null}function ku(e,t){do{Tu()}while(null!==Gi);if(0!=(48&xi))throw Error(o(327));var n=e.finishedWork;if(null===n)return null;if(e.finishedWork=null,e.finishedLanes=0,n===e.current)throw Error(o(177));e.callbackNode=null;var r=n.lanes|n.childLanes,a=r,l=e.pendingLanes&~a;e.pendingLanes=a,e.suspendedLanes=0,e.pingedLanes=0,e.expiredLanes&=a,e.mutableReadLanes&=a,e.entangledLanes&=a,a=e.entanglements;for(var i=e.eventTimes,u=e.expirationTimes;0<l;){var s=31-Vt(l),c=1<<s;a[s]=0,i[s]=-1,u[s]=-1,l&=~c}if(null!==Xi&&0==(24&r)&&Xi.has(e)&&Xi.delete(e),e===ki&&(ji=ki=null,Ti=0),1<n.flags?null!==n.lastEffect?(n.lastEffect.nextEffect=n,r=n.firstEffect):r=n:r=n.firstEffect,null!==r){if(a=xi,xi|=32,Si.current=null,Pr=Gt,pr(i=dr())){if("selectionStart"in i)u={start:i.selectionStart,end:i.selectionEnd};else e:if(u=(u=i.ownerDocument)&&u.defaultView||window,(c=u.getSelection&&u.getSelection())&&0!==c.rangeCount){u=c.anchorNode,l=c.anchorOffset,s=c.focusNode,c=c.focusOffset;try{u.nodeType,s.nodeType}catch(e){u=null;break e}var f=0,d=-1,p=-1,y=0,h=0,g=i,m=null;t:for(;;){for(var v;g!==u||0!==l&&3!==g.nodeType||(d=f+l),g!==s||0!==c&&3!==g.nodeType||(p=f+c),3===g.nodeType&&(f+=g.nodeValue.length),null!==(v=g.firstChild);)m=g,g=v;for(;;){if(g===i)break t;if(m===u&&++y===l&&(d=f),m===s&&++h===c&&(p=f),null!==(v=g.nextSibling))break;m=(g=m).parentNode}g=v}u=-1===d||-1===p?null:{start:d,end:p}}else u=null;u=u||{start:0,end:0}}else u=null;Ur={focusedElem:i,selectionRange:u},Gt=!1,au=null,lu=!1,Vi=r;do{try{ju()}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);au=null,Vi=r;do{try{for(i=e;null!==Vi;){var b=Vi.flags;if(16&b&&me(Vi.stateNode,""),128&b){var M=Vi.alternate;if(null!==M){var E=M.ref;null!==E&&("function"==typeof E?E(null):E.current=null)}}switch(1038&b){case 2:gi(Vi),Vi.flags&=-3;break;case 6:gi(Vi),Vi.flags&=-3,Mi(Vi.alternate,Vi);break;case 1024:Vi.flags&=-1025;break;case 1028:Vi.flags&=-1025,Mi(Vi.alternate,Vi);break;case 4:Mi(Vi.alternate,Vi);break;case 8:bi(i,u=Vi);var L=u.alternate;yi(u),null!==L&&yi(L)}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);if(E=Ur,M=dr(),b=E.focusedElem,i=E.selectionRange,M!==b&&b&&b.ownerDocument&&fr(b.ownerDocument.documentElement,b)){null!==i&&pr(b)&&(M=i.start,void 0===(E=i.end)&&(E=M),"selectionStart"in b?(b.selectionStart=M,b.selectionEnd=Math.min(E,b.value.length)):(E=(M=b.ownerDocument||document)&&M.defaultView||window).getSelection&&(E=E.getSelection(),u=b.textContent.length,L=Math.min(i.start,u),i=void 0===i.end?L:Math.min(i.end,u),!E.extend&&L>i&&(u=i,i=L,L=u),u=cr(b,L),l=cr(b,i),u&&l&&(1!==E.rangeCount||E.anchorNode!==u.node||E.anchorOffset!==u.offset||E.focusNode!==l.node||E.focusOffset!==l.offset)&&((M=M.createRange()).setStart(u.node,u.offset),E.removeAllRanges(),L>i?(E.addRange(M),E.extend(l.node,l.offset)):(M.setEnd(l.node,l.offset),E.addRange(M))))),M=[];for(E=b;E=E.parentNode;)1===E.nodeType&&M.push({element:E,left:E.scrollLeft,top:E.scrollTop});for("function"==typeof b.focus&&b.focus(),b=0;b<M.length;b++)(E=M[b]).element.scrollLeft=E.left,E.element.scrollTop=E.top}Gt=!!Pr,Ur=Pr=null,e.current=n,Vi=r;do{try{for(b=e;null!==Vi;){var N=Vi.flags;if(36&N&&fi(b,Vi.alternate,Vi),128&N){M=void 0;var w=Vi.ref;if(null!==w){var S=Vi.stateNode;switch(Vi.tag){case 5:M=S;break;default:M=S}"function"==typeof w?w(M):w.current=M}}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);Vi=null,za(),xi=a}else e.current=n;if(Ki)Ki=!1,Gi=e,$i=t;else for(Vi=r;null!==Vi;)t=Vi.nextEffect,Vi.nextEffect=null,8&Vi.flags&&((N=Vi).sibling=null,N.stateNode=null),Vi=t;if(0===(r=e.pendingLanes)&&(Hi=null),1===r?e===eu?Ji++:(Ji=0,eu=e):Ji=0,n=n.stateNode,Ma&&"function"==typeof Ma.onCommitFiberRoot)try{Ma.onCommitFiberRoot(ba,n,void 0,64==(64&n.current.flags))}catch(e){}if(cu(e,Ya()),Bi)throw Bi=!1,e=Wi,Wi=null,e;return 0!=(8&xi)||Ba(),null}function ju(){for(;null!==Vi;){var e=Vi.alternate;lu||null===au||(0!=(8&Vi.flags)?Je(Vi,au)&&(lu=!0):13===Vi.tag&&Li(e,Vi)&&Je(Vi,au)&&(lu=!0));var t=Vi.flags;0!=(256&t)&&ci(e,Vi),0==(512&t)||Ki||(Ki=!0,Va(97,(function(){return Tu(),null}))),Vi=Vi.nextEffect}}function Tu(){if(90!==$i){var e=97<$i?97:$i;return $i=90,Fa(e,Du)}return!1}function Cu(e,t){qi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Iu(e,t){Zi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Du(){if(null===Gi)return!1;var e=Gi;if(Gi=null,0!=(48&xi))throw Error(o(331));var t=xi;xi|=32;var n=Zi;Zi=[];for(var r=0;r<n.length;r+=2){var a=n[r],l=n[r+1],i=a.destroy;if(a.destroy=void 0,"function"==typeof i)try{i()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(n=qi,qi=[],r=0;r<n.length;r+=2){a=n[r],l=n[r+1];try{var u=a.create;a.destroy=u()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(u=e.current.firstEffect;null!==u;)e=u.nextEffect,u.nextEffect=null,8&u.flags&&(u.sibling=null,u.stateNode=null),u=e;return xi=t,Ba(),!0}function Ou(e,t,n){il(e,t=oi(0,t=ri(n,t),1)),t=ou(),null!==(e=su(e,1))&&(Ft(e,1,t),cu(e,t))}function zu(e,t){if(3===e.tag)Ou(e,e,t);else for(var n=e.return;null!==n;){if(3===n.tag){Ou(n,e,t);break}if(1===n.tag){var r=n.stateNode;if("function"==typeof n.type.getDerivedStateFromError||"function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r))){var a=ii(n,e=ri(t,e),1);if(il(n,a),a=ou(),null!==(n=su(n,1)))Ft(n,1,a),cu(n,a);else if("function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r)))try{r.componentDidCatch(t,e)}catch(e){}break}}n=n.return}}function Au(e,t,n){var r=e.pingCache;null!==r&&r.delete(t),t=ou(),e.pingedLanes|=e.suspendedLanes&n,ki===e&&(Ti&n)===n&&(4===Di||3===Di&&(62914560&Ti)===Ti&&500>Ya()-Yi?vu(e,0):Pi|=n),cu(e,t)}function _u(e,t){var n=e.stateNode;null!==n&&n.delete(t),0==(t=0)&&(0==(2&(t=e.mode))?t=1:0==(4&t)?t=99===Qa()?1:2:(0===nu&&(nu=zi),0===(t=Qt(62914560&~nu))&&(t=4194304))),n=ou(),null!==(e=su(e,t))&&(Ft(e,t,n),cu(e,n))}function Pu(e,t,n,r){this.tag=e,this.key=n,this.sibling=this.child=this.return=this.stateNode=this.type=this.elementType=null,this.index=0,this.ref=null,this.pendingProps=t,this.dependencies=this.memoizedState=this.updateQueue=this.memoizedProps=null,this.mode=r,this.flags=0,this.lastEffect=this.firstEffect=this.nextEffect=null,this.childLanes=this.lanes=0,this.alternate=null}function Uu(e,t,n,r){return new Pu(e,t,n,r)}function Yu(e){return!(!(e=e.prototype)||!e.isReactComponent)}function Qu(e,t){var n=e.alternate;return null===n?((n=Uu(e.tag,t,e.key,e.mode)).elementType=e.elementType,n.type=e.type,n.stateNode=e.stateNode,n.alternate=e,e.alternate=n):(n.pendingProps=t,n.type=e.type,n.flags=0,n.nextEffect=null,n.firstEffect=null,n.lastEffect=null),n.childLanes=e.childLanes,n.lanes=e.lanes,n.child=e.child,n.memoizedProps=e.memoizedProps,n.memoizedState=e.memoizedState,n.updateQueue=e.updateQueue,t=e.dependencies,n.dependencies=null===t?null:{lanes:t.lanes,firstContext:t.firstContext},n.sibling=e.sibling,n.index=e.index,n.ref=e.ref,n}function Ru(e,t,n,r,a,l){var i=2;if(r=e,"function"==typeof e)Yu(e)&&(i=1);else if("string"==typeof e)i=5;else e:switch(e){case w:return Fu(n.children,a,l,t);case _:i=8,a|=16;break;case S:i=8,a|=1;break;case x:return(e=Uu(12,n,t,8|a)).elementType=x,e.type=x,e.lanes=l,e;case C:return(e=Uu(13,n,t,a)).type=C,e.elementType=C,e.lanes=l,e;case I:return(e=Uu(19,n,t,a)).elementType=I,e.lanes=l,e;case P:return Vu(n,a,l,t);case U:return(e=Uu(24,n,t,a)).elementType=U,e.lanes=l,e;default:if("object"==typeof e&&null!==e)switch(e.$$typeof){case k:i=10;break e;case j:i=9;break e;case T:i=11;break e;case D:i=14;break e;case O:i=16,r=null;break e;case z:i=22;break e}throw Error(o(130,null==e?e:typeof e,""))}return(t=Uu(i,n,t,a)).elementType=e,t.type=r,t.lanes=l,t}function Fu(e,t,n,r){return(e=Uu(7,e,r,t)).lanes=n,e}function Vu(e,t,n,r){return(e=Uu(23,e,r,t)).elementType=P,e.lanes=n,e}function Bu(e,t,n){return(e=Uu(6,e,null,t)).lanes=n,e}function Wu(e,t,n){return(t=Uu(4,null!==e.children?e.children:[],e.key,t)).lanes=n,t.stateNode={containerInfo:e.containerInfo,pendingChildren:null,implementation:e.implementation},t}function Hu(e,t,n){this.tag=t,this.containerInfo=e,this.finishedWork=this.pingCache=this.current=this.pendingChildren=null,this.timeoutHandle=-1,this.pendingContext=this.context=null,this.hydrate=n,this.callbackNode=null,this.callbackPriority=0,this.eventTimes=Rt(0),this.expirationTimes=Rt(-1),this.entangledLanes=this.finishedLanes=this.mutableReadLanes=this.expiredLanes=this.pingedLanes=this.suspendedLanes=this.pendingLanes=0,this.entanglements=Rt(0),this.mutableSourceEagerHydrationData=null}function Ku(e,t,n){var r=3<arguments.length&&void 0!==arguments[3]?arguments[3]:null;return{$$typeof:N,key:null==r?null:""+r,children:e,containerInfo:t,implementation:n}}function Gu(e,t,n,r){var a=t.current,l=ou(),i=iu(a);e:if(n){t:{if($e(n=n._reactInternals)!==n||1!==n.tag)throw Error(o(170));var u=n;do{switch(u.tag){case 3:u=u.stateNode.context;break t;case 1:if(pa(u.type)){u=u.stateNode.__reactInternalMemoizedMergedChildContext;break t}}u=u.return}while(null!==u);throw Error(o(171))}if(1===n.tag){var s=n.type;if(pa(s)){n=ga(n,s,u);break e}}n=u}else n=ua;return null===t.context?t.context=n:t.pendingContext=n,(t=ol(l,i)).payload={element:e},null!==(r=void 0===r?null:r)&&(t.callback=r),il(a,t),uu(a,i,l),i}function $u(e){if(!(e=e.current).child)return null;switch(e.child.tag){case 5:default:return e.child.stateNode}}function qu(e,t){if(null!==(e=e.memoizedState)&&null!==e.dehydrated){var n=e.retryLane;e.retryLane=0!==n&&n<t?n:t}}function Zu(e,t){qu(e,t),(e=e.alternate)&&qu(e,t)}function Xu(e,t,n){var r=null!=n&&null!=n.hydrationOptions&&n.hydrationOptions.mutableSources||null;if(n=new Hu(e,t,null!=n&&!0===n.hydrate),t=Uu(3,null,null,2===t?7:1===t?3:0),n.current=t,t.stateNode=n,al(t),e[qr]=n.current,jr(8===e.nodeType?e.parentNode:e),r)for(e=0;e<r.length;e++){var a=(t=r[e])._getVersion;a=a(t._source),null==n.mutableSourceEagerHydrationData?n.mutableSourceEagerHydrationData=[t,a]:n.mutableSourceEagerHydrationData.push(t,a)}this._internalRoot=n}function Ju(e){return!(!e||1!==e.nodeType&&9!==e.nodeType&&11!==e.nodeType&&(8!==e.nodeType||" react-mount-point-unstable "!==e.nodeValue))}function es(e,t,n,r,a){var l=n._reactRootContainer;if(l){var o=l._internalRoot;if("function"==typeof a){var i=a;a=function(){var e=$u(o);i.call(e)}}Gu(t,o,e,a)}else{if(l=n._reactRootContainer=function(e,t){if(t||(t=!(!(t=e?9===e.nodeType?e.documentElement:e.firstChild:null)||1!==t.nodeType||!t.hasAttribute("data-reactroot"))),!t)for(var n;n=e.lastChild;)e.removeChild(n);return new Xu(e,0,t?{hydrate:!0}:void 0)}(n,r),o=l._internalRoot,"function"==typeof a){var u=a;a=function(){var e=$u(o);u.call(e)}}hu((function(){Gu(t,o,e,a)}))}return $u(o)}function ts(e,t){var n=2<arguments.length&&void 0!==arguments[2]?arguments[2]:null;if(!Ju(t))throw Error(o(200));return Ku(e,t,null,n)}Fi=function(e,t,n){var r=t.lanes;if(null!==e)if(e.memoizedProps!==t.pendingProps||ca.current)Oo=!0;else{if(0==(n&r)){switch(Oo=!1,t.tag){case 3:Vo(t),Vl();break;case 5:Il(t);break;case 1:pa(t.type)&&ma(t);break;case 4:Tl(t,t.stateNode.containerInfo);break;case 10:r=t.memoizedProps.value;var a=t.type._context;ia(Ga,a._currentValue),a._currentValue=r;break;case 13:if(null!==t.memoizedState)return 0!=(n&t.child.childLanes)?Go(e,t,n):(ia(Ol,1&Ol.current),null!==(t=Jo(e,t,n))?t.sibling:null);ia(Ol,1&Ol.current);break;case 19:if(r=0!=(n&t.childLanes),0!=(64&e.flags)){if(r)return Xo(e,t,n);t.flags|=64}if(null!==(a=t.memoizedState)&&(a.rendering=null,a.tail=null,a.lastEffect=null),ia(Ol,Ol.current),r)break;return null;case 23:case 24:return t.lanes=0,Uo(e,t,n)}return Jo(e,t,n)}Oo=0!=(16384&e.flags)}else Oo=!1;switch(t.lanes=0,t.tag){case 2:if(r=t.type,null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=da(t,sa.current),tl(t,n),a=no(null,t,r,e,a,n),t.flags|=1,"object"==typeof a&&null!==a&&"function"==typeof a.render&&void 0===a.$$typeof){if(t.tag=1,t.memoizedState=null,t.updateQueue=null,pa(r)){var l=!0;ma(t)}else l=!1;t.memoizedState=null!==a.state&&void 0!==a.state?a.state:null,al(t);var i=r.getDerivedStateFromProps;"function"==typeof i&&dl(t,r,i,e),a.updater=pl,t.stateNode=a,a._reactInternals=t,ml(t,r,e,n),t=Fo(null,t,r,!0,l,n)}else t.tag=0,zo(null,t,a,n),t=t.child;return t;case 16:a=t.elementType;e:{switch(null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=(l=a._init)(a._payload),t.type=a,l=t.tag=function(e){if("function"==typeof e)return Yu(e)?1:0;if(null!=e){if((e=e.$$typeof)===T)return 11;if(e===D)return 14}return 2}(a),e=Ka(a,e),l){case 0:t=Qo(null,t,a,e,n);break e;case 1:t=Ro(null,t,a,e,n);break e;case 11:t=Ao(null,t,a,e,n);break e;case 14:t=_o(null,t,a,Ka(a.type,e),r,n);break e}throw Error(o(306,a,""))}return t;case 0:return r=t.type,a=t.pendingProps,Qo(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 1:return r=t.type,a=t.pendingProps,Ro(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 3:if(Vo(t),r=t.updateQueue,null===e||null===r)throw Error(o(282));if(r=t.pendingProps,a=null!==(a=t.memoizedState)?a.element:null,ll(e,t),sl(t,r,null,n),(r=t.memoizedState.element)===a)Vl(),t=Jo(e,t,n);else{if((l=(a=t.stateNode).hydrate)&&(_l=Br(t.stateNode.containerInfo.firstChild),Al=t,l=Pl=!0),l){if(null!=(e=a.mutableSourceEagerHydrationData))for(a=0;a<e.length;a+=2)(l=e[a])._workInProgressVersionPrimary=e[a+1],Bl.push(l);for(n=Nl(t,null,r,n),t.child=n;n;)n.flags=-3&n.flags|1024,n=n.sibling}else zo(e,t,r,n),Vl();t=t.child}return t;case 5:return Il(t),null===e&&Ql(t),r=t.type,a=t.pendingProps,l=null!==e?e.memoizedProps:null,i=a.children,Qr(r,a)?i=null:null!==l&&Qr(r,l)&&(t.flags|=16),Yo(e,t),zo(e,t,i,n),t.child;case 6:return null===e&&Ql(t),null;case 13:return Go(e,t,n);case 4:return Tl(t,t.stateNode.containerInfo),r=t.pendingProps,null===e?t.child=Ll(t,null,r,n):zo(e,t,r,n),t.child;case 11:return r=t.type,a=t.pendingProps,Ao(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 7:return zo(e,t,t.pendingProps,n),t.child;case 8:case 12:return zo(e,t,t.pendingProps.children,n),t.child;case 10:e:{r=t.type._context,a=t.pendingProps,i=t.memoizedProps,l=a.value;var u=t.type._context;if(ia(Ga,u._currentValue),u._currentValue=l,null!==i)if(u=i.value,0==(l=or(u,l)?0:0|("function"==typeof r._calculateChangedBits?r._calculateChangedBits(u,l):1073741823))){if(i.children===a.children&&!ca.current){t=Jo(e,t,n);break e}}else for(null!==(u=t.child)&&(u.return=t);null!==u;){var s=u.dependencies;if(null!==s){i=u.child;for(var c=s.firstContext;null!==c;){if(c.context===r&&0!=(c.observedBits&l)){1===u.tag&&((c=ol(-1,n&-n)).tag=2,il(u,c)),u.lanes|=n,null!==(c=u.alternate)&&(c.lanes|=n),el(u.return,n),s.lanes|=n;break}c=c.next}}else i=10===u.tag&&u.type===t.type?null:u.child;if(null!==i)i.return=u;else for(i=u;null!==i;){if(i===t){i=null;break}if(null!==(u=i.sibling)){u.return=i.return,i=u;break}i=i.return}u=i}zo(e,t,a.children,n),t=t.child}return t;case 9:return a=t.type,r=(l=t.pendingProps).children,tl(t,n),r=r(a=nl(a,l.unstable_observedBits)),t.flags|=1,zo(e,t,r,n),t.child;case 14:return l=Ka(a=t.type,t.pendingProps),_o(e,t,a,l=Ka(a.type,l),r,n);case 15:return Po(e,t,t.type,t.pendingProps,r,n);case 17:return r=t.type,a=t.pendingProps,a=t.elementType===r?a:Ka(r,a),null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),t.tag=1,pa(r)?(e=!0,ma(t)):e=!1,tl(t,n),hl(t,r,a),ml(t,r,a,n),Fo(null,t,r,!0,e,n);case 19:return Xo(e,t,n);case 23:case 24:return Uo(e,t,n)}throw Error(o(156,t.tag))},Xu.prototype.render=function(e){Gu(e,this._internalRoot,null,null)},Xu.prototype.unmount=function(){var e=this._internalRoot,t=e.containerInfo;Gu(null,e,null,(function(){t[qr]=null}))},et=function(e){13===e.tag&&(uu(e,4,ou()),Zu(e,4))},tt=function(e){13===e.tag&&(uu(e,67108864,ou()),Zu(e,67108864))},nt=function(e){if(13===e.tag){var t=ou(),n=iu(e);uu(e,n,t),Zu(e,n)}},rt=function(e,t){return t()},xe=function(e,t,n){switch(t){case"input":if(ne(e,n),t=n.name,"radio"===n.type&&null!=t){for(n=e;n.parentNode;)n=n.parentNode;for(n=n.querySelectorAll("input[name="+JSON.stringify(""+t)+'][type="radio"]'),t=0;t<n.length;t++){var r=n[t];if(r!==e&&r.form===e.form){var a=ta(r);if(!a)throw Error(o(90));Z(r),ne(r,a)}}}break;case"textarea":se(e,n);break;case"select":null!=(t=n.value)&&oe(e,!!n.multiple,t,!1)}},De=yu,Oe=function(e,t,n,r,a){var l=xi;xi|=4;try{return Fa(98,e.bind(null,t,n,r,a))}finally{0===(xi=l)&&(Ri(),Ba())}},ze=function(){0==(49&xi)&&(function(){if(null!==Xi){var e=Xi;Xi=null,e.forEach((function(e){e.expiredLanes|=24&e.pendingLanes,cu(e,Ya())}))}Ba()}(),Tu())},Ae=function(e,t){var n=xi;xi|=2;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}};var ns={Events:[Jr,ea,ta,Ce,Ie,Tu,{current:!1}]},rs={findFiberByHostInstance:Xr,bundleType:0,version:"17.0.2",rendererPackageName:"react-dom"},as={bundleType:rs.bundleType,version:rs.version,rendererPackageName:rs.rendererPackageName,rendererConfig:rs.rendererConfig,overrideHookState:null,overrideHookStateDeletePath:null,overrideHookStateRenamePath:null,overrideProps:null,overridePropsDeletePath:null,overridePropsRenamePath:null,setSuspenseHandler:null,scheduleUpdate:null,currentDispatcherRef:E.ReactCurrentDispatcher,findHostInstanceByFiber:function(e){return null===(e=Xe(e))?null:e.stateNode},findFiberByHostInstance:rs.findFiberByHostInstance||function(){return null},findHostInstancesForRefresh:null,scheduleRefresh:null,scheduleRoot:null,setRefreshHandler:null,getCurrentFiber:null};if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__){var ls=__REACT_DEVTOOLS_GLOBAL_HOOK__;if(!ls.isDisabled&&ls.supportsFiber)try{ba=ls.inject(as),Ma=ls}catch(he){}}t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=ns,t.createPortal=ts,t.findDOMNode=function(e){if(null==e)return null;if(1===e.nodeType)return e;var t=e._reactInternals;if(void 0===t){if("function"==typeof e.render)throw Error(o(188));throw Error(o(268,Object.keys(e)))}return null===(e=Xe(t))?null:e.stateNode},t.flushSync=function(e,t){var n=xi;if(0!=(48&n))return e(t);xi|=1;try{if(e)return Fa(99,e.bind(null,t))}finally{xi=n,Ba()}},t.hydrate=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!0,n)},t.render=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!1,n)},t.unmountComponentAtNode=function(e){if(!Ju(e))throw Error(o(40));return!!e._reactRootContainer&&(hu((function(){es(null,null,e,!1,(function(){e._reactRootContainer=null,e[qr]=null}))})),!0)},t.unstable_batchedUpdates=yu,t.unstable_createPortal=function(e,t){return ts(e,t,2<arguments.length&&void 0!==arguments[2]?arguments[2]:null)},t.unstable_renderSubtreeIntoContainer=function(e,t,n,r){if(!Ju(n))throw Error(o(200));if(null==e||void 0===e._reactInternals)throw Error(o(38));return es(e,t,n,!1,r)},t.version="17.0.2"},935:(e,t,n)=>{"use strict";!function e(){if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__&&"function"==typeof __REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE)try{__REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE(e)}catch(e){console.error(e)}}(),e.exports=n(448)},357:(e,t,n)=>{"use strict";function r(){return(r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e}).apply(this,arguments)}function a(e,t){if(null==e)return{};var n,r,a={},l=Object.keys(e);for(r=0;r<l.length;r++)n=l[r],t.indexOf(n)>=0||(a[n]=e[n]);return a}function l(e,t){return(l=Object.setPrototypeOf||function(e,t){return e.__proto__=t,e})(e,t)}function o(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,l(e,t)}function i(e,t){return e.replace(new RegExp("(^|\\s)"+t+"(?:\\s|$)","g"),"$1").replace(/\s+/g," ").replace(/^\s*|\s*$/g,"")}n.r(t),n.d(t,{CSSTransition:()=>N,ReplaceTransition:()=>I,SwitchTransition:()=>Q,Transition:()=>M,TransitionGroup:()=>T,config:()=>c});var u=n(294),s=n(935);const c={disabled:!1},f=u.createContext(null);var d=function(e){return e.scrollTop},p="unmounted",y="exited",h="entering",g="entered",m="exiting",v=function(e){function t(t,n){var r;r=e.call(this,t,n)||this;var a,l=n&&!n.isMounting?t.enter:t.appear;return r.appearStatus=null,t.in?l?(a=y,r.appearStatus=h):a=g:a=t.unmountOnExit||t.mountOnEnter?p:y,r.state={status:a},r.nextCallback=null,r}o(t,e),t.getDerivedStateFromProps=function(e,t){return e.in&&t.status===p?{status:y}:null};var n=t.prototype;return n.componentDidMount=function(){this.updateStatus(!0,this.appearStatus)},n.componentDidUpdate=function(e){var t=null;if(e!==this.props){var n=this.state.status;this.props.in?n!==h&&n!==g&&(t=h):n!==h&&n!==g||(t=m)}this.updateStatus(!1,t)},n.componentWillUnmount=function(){this.cancelNextCallback()},n.getTimeouts=function(){var e,t,n,r=this.props.timeout;return e=t=n=r,null!=r&&"number"!=typeof r&&(e=r.exit,t=r.enter,n=void 0!==r.appear?r.appear:t),{exit:e,enter:t,appear:n}},n.updateStatus=function(e,t){if(void 0===e&&(e=!1),null!==t)if(this.cancelNextCallback(),t===h){if(this.props.unmountOnExit||this.props.mountOnEnter){var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this);n&&d(n)}this.performEnter(e)}else this.performExit();else this.props.unmountOnExit&&this.state.status===y&&this.setState({status:p})},n.performEnter=function(e){var t=this,n=this.props.enter,r=this.context?this.context.isMounting:e,a=this.props.nodeRef?[r]:[s.findDOMNode(this),r],l=a[0],o=a[1],i=this.getTimeouts(),u=r?i.appear:i.enter;!e&&!n||c.disabled?this.safeSetState({status:g},(function(){t.props.onEntered(l)})):(this.props.onEnter(l,o),this.safeSetState({status:h},(function(){t.props.onEntering(l,o),t.onTransitionEnd(u,(function(){t.safeSetState({status:g},(function(){t.props.onEntered(l,o)}))}))})))},n.performExit=function(){var e=this,t=this.props.exit,n=this.getTimeouts(),r=this.props.nodeRef?void 0:s.findDOMNode(this);t&&!c.disabled?(this.props.onExit(r),this.safeSetState({status:m},(function(){e.props.onExiting(r),e.onTransitionEnd(n.exit,(function(){e.safeSetState({status:y},(function(){e.props.onExited(r)}))}))}))):this.safeSetState({status:y},(function(){e.props.onExited(r)}))},n.cancelNextCallback=function(){null!==this.nextCallback&&(this.nextCallback.cancel(),this.nextCallback=null)},n.safeSetState=function(e,t){t=this.setNextCallback(t),this.setState(e,t)},n.setNextCallback=function(e){var t=this,n=!0;return this.nextCallback=function(r){n&&(n=!1,t.nextCallback=null,e(r))},this.nextCallback.cancel=function(){n=!1},this.nextCallback},n.onTransitionEnd=function(e,t){this.setNextCallback(t);var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this),r=null==e&&!this.props.addEndListener;if(n&&!r){if(this.props.addEndListener){var a=this.props.nodeRef?[this.nextCallback]:[n,this.nextCallback],l=a[0],o=a[1];this.props.addEndListener(l,o)}null!=e&&setTimeout(this.nextCallback,e)}else setTimeout(this.nextCallback,0)},n.render=function(){var e=this.state.status;if(e===p)return null;var t=this.props,n=t.children,r=(t.in,t.mountOnEnter,t.unmountOnExit,t.appear,t.enter,t.exit,t.timeout,t.addEndListener,t.onEnter,t.onEntering,t.onEntered,t.onExit,t.onExiting,t.onExited,t.nodeRef,a(t,["children","in","mountOnEnter","unmountOnExit","appear","enter","exit","timeout","addEndListener","onEnter","onEntering","onEntered","onExit","onExiting","onExited","nodeRef"]));return u.createElement(f.Provider,{value:null},"function"==typeof n?n(e,r):u.cloneElement(u.Children.only(n),r))},t}(u.Component);function b(){}v.contextType=f,v.propTypes={},v.defaultProps={in:!1,mountOnEnter:!1,unmountOnExit:!1,appear:!1,enter:!0,exit:!0,onEnter:b,onEntering:b,onEntered:b,onExit:b,onExiting:b,onExited:b},v.UNMOUNTED=p,v.EXITED=y,v.ENTERING=h,v.ENTERED=g,v.EXITING=m;const M=v;var E=function(e,t){return e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.remove(r):"string"==typeof n.className?n.className=i(n.className,r):n.setAttribute("class",i(n.className&&n.className.baseVal||"",r)));var n,r}))},L=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).appliedClasses={appear:{},enter:{},exit:{}},t.onEnter=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1];t.removeClasses(a,"exit"),t.addClass(a,l?"appear":"enter","base"),t.props.onEnter&&t.props.onEnter(e,n)},t.onEntering=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.addClass(a,l,"active"),t.props.onEntering&&t.props.onEntering(e,n)},t.onEntered=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.removeClasses(a,l),t.addClass(a,l,"done"),t.props.onEntered&&t.props.onEntered(e,n)},t.onExit=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"appear"),t.removeClasses(n,"enter"),t.addClass(n,"exit","base"),t.props.onExit&&t.props.onExit(e)},t.onExiting=function(e){var n=t.resolveArguments(e)[0];t.addClass(n,"exit","active"),t.props.onExiting&&t.props.onExiting(e)},t.onExited=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"exit"),t.addClass(n,"exit","done"),t.props.onExited&&t.props.onExited(e)},t.resolveArguments=function(e,n){return t.props.nodeRef?[t.props.nodeRef.current,e]:[e,n]},t.getClassNames=function(e){var n=t.props.classNames,r="string"==typeof n,a=r?(r&&n?n+"-":"")+e:n[e];return{baseClassName:a,activeClassName:r?a+"-active":n[e+"Active"],doneClassName:r?a+"-done":n[e+"Done"]}},t}o(t,e);var n=t.prototype;return n.addClass=function(e,t,n){var r=this.getClassNames(t)[n+"ClassName"],a=this.getClassNames("enter").doneClassName;"appear"===t&&"done"===n&&a&&(r+=" "+a),"active"===n&&e&&d(e),r&&(this.appliedClasses[t][n]=r,function(e,t){e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.add(r):function(e,t){return e.classList?!!t&&e.classList.contains(t):-1!==(" "+(e.className.baseVal||e.className)+" ").indexOf(" "+t+" ")}(n,r)||("string"==typeof n.className?n.className=n.className+" "+r:n.setAttribute("class",(n.className&&n.className.baseVal||"")+" "+r)));var n,r}))}(e,r))},n.removeClasses=function(e,t){var n=this.appliedClasses[t],r=n.base,a=n.active,l=n.done;this.appliedClasses[t]={},r&&E(e,r),a&&E(e,a),l&&E(e,l)},n.render=function(){var e=this.props,t=(e.classNames,a(e,["classNames"]));return u.createElement(M,r({},t,{onEnter:this.onEnter,onEntered:this.onEntered,onEntering:this.onEntering,onExit:this.onExit,onExiting:this.onExiting,onExited:this.onExited}))},t}(u.Component);L.defaultProps={classNames:""},L.propTypes={};const N=L;function w(e,t){var n=Object.create(null);return e&&u.Children.map(e,(function(e){return e})).forEach((function(e){n[e.key]=function(e){return t&&(0,u.isValidElement)(e)?t(e):e}(e)})),n}function S(e,t,n){return null!=n[t]?n[t]:e.props[t]}function x(e,t,n){var r=w(e.children),a=function(e,t){function n(n){return n in t?t[n]:e[n]}e=e||{},t=t||{};var r,a=Object.create(null),l=[];for(var o in e)o in t?l.length&&(a[o]=l,l=[]):l.push(o);var i={};for(var u in t){if(a[u])for(r=0;r<a[u].length;r++){var s=a[u][r];i[a[u][r]]=n(s)}i[u]=n(u)}for(r=0;r<l.length;r++)i[l[r]]=n(l[r]);return i}(t,r);return Object.keys(a).forEach((function(l){var o=a[l];if((0,u.isValidElement)(o)){var i=l in t,s=l in r,c=t[l],f=(0,u.isValidElement)(c)&&!c.props.in;!s||i&&!f?s||!i||f?s&&i&&(0,u.isValidElement)(c)&&(a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:c.props.in,exit:S(o,"exit",e),enter:S(o,"enter",e)})):a[l]=(0,u.cloneElement)(o,{in:!1}):a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:!0,exit:S(o,"exit",e),enter:S(o,"enter",e)})}})),a}var k=Object.values||function(e){return Object.keys(e).map((function(t){return e[t]}))},j=function(e){function t(t,n){var r,a=(r=e.call(this,t,n)||this).handleExited.bind(function(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}(r));return r.state={contextValue:{isMounting:!0},handleExited:a,firstRender:!0},r}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.mounted=!0,this.setState({contextValue:{isMounting:!1}})},n.componentWillUnmount=function(){this.mounted=!1},t.getDerivedStateFromProps=function(e,t){var n,r,a=t.children,l=t.handleExited;return{children:t.firstRender?(n=e,r=l,w(n.children,(function(e){return(0,u.cloneElement)(e,{onExited:r.bind(null,e),in:!0,appear:S(e,"appear",n),enter:S(e,"enter",n),exit:S(e,"exit",n)})}))):x(e,a,l),firstRender:!1}},n.handleExited=function(e,t){var n=w(this.props.children);e.key in n||(e.props.onExited&&e.props.onExited(t),this.mounted&&this.setState((function(t){var n=r({},t.children);return delete n[e.key],{children:n}})))},n.render=function(){var e=this.props,t=e.component,n=e.childFactory,r=a(e,["component","childFactory"]),l=this.state.contextValue,o=k(this.state.children).map(n);return delete r.appear,delete r.enter,delete r.exit,null===t?u.createElement(f.Provider,{value:l},o):u.createElement(f.Provider,{value:l},u.createElement(t,r,o))},t}(u.Component);j.propTypes={},j.defaultProps={component:"div",childFactory:function(e){return e}};const T=j;var C=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).handleEnter=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEnter",0,n)},t.handleEntering=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntering",0,n)},t.handleEntered=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntered",0,n)},t.handleExit=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExit",1,n)},t.handleExiting=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExiting",1,n)},t.handleExited=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExited",1,n)},t}o(t,e);var n=t.prototype;return n.handleLifecycle=function(e,t,n){var r,a=this.props.children,l=u.Children.toArray(a)[t];if(l.props[e]&&(r=l.props)[e].apply(r,n),this.props[e]){var o=l.props.nodeRef?void 0:s.findDOMNode(this);this.props[e](o)}},n.render=function(){var e=this.props,t=e.children,n=e.in,r=a(e,["children","in"]),l=u.Children.toArray(t),o=l[0],i=l[1];return delete r.onEnter,delete r.onEntering,delete r.onEntered,delete r.onExit,delete r.onExiting,delete r.onExited,u.createElement(T,r,n?u.cloneElement(o,{key:"first",onEnter:this.handleEnter,onEntering:this.handleEntering,onEntered:this.handleEntered}):u.cloneElement(i,{key:"second",onEnter:this.handleExit,onEntering:this.handleExiting,onEntered:this.handleExited}))},t}(u.Component);C.propTypes={};const I=C;var D,O,z="out-in",A="in-out",_=function(e,t,n){return function(){var r;e.props[t]&&(r=e.props)[t].apply(r,arguments),n()}},P=((D={})["out-in"]=function(e){var t=e.current,n=e.changeState;return u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){n(h,null)}))})},D[A]=function(e){var t=e.current,n=e.changeState,r=e.children;return[t,u.cloneElement(r,{in:!0,onEntered:_(r,"onEntered",(function(){n(h)}))})]},D),U=((O={})["out-in"]=function(e){var t=e.children,n=e.changeState;return u.cloneElement(t,{in:!0,onEntered:_(t,"onEntered",(function(){n(g,u.cloneElement(t,{in:!0}))}))})},O[A]=function(e){var t=e.current,n=e.children,r=e.changeState;return[u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){r(g,u.cloneElement(n,{in:!0}))}))}),u.cloneElement(n,{in:!0})]},O),Y=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).state={status:g,current:null},t.appeared=!1,t.changeState=function(e,n){void 0===n&&(n=t.state.current),t.setState({status:e,current:n})},t}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.appeared=!0},t.getDerivedStateFromProps=function(e,t){return null==e.children?{current:null}:t.status===h&&e.mode===A?{status:h}:!t.current||((n=t.current)===(r=e.children)||u.isValidElement(n)&&u.isValidElement(r)&&null!=n.key&&n.key===r.key)?{current:u.cloneElement(e.children,{in:!0})}:{status:m};var n,r},n.render=function(){var e,t=this.props,n=t.children,r=t.mode,a=this.state,l=a.status,o=a.current,i={children:n,current:o,changeState:this.changeState,status:l};switch(l){case h:e=U[r](i);break;case m:e=P[r](i);break;case g:e=o}return u.createElement(f.Provider,{value:{isMounting:!this.appeared}},e)},t}(u.Component);Y.propTypes={},Y.defaultProps={mode:z};const Q=Y},408:(e,t,n)=>{"use strict";var r=n(418),a=60103,l=60106;t.Fragment=60107,t.StrictMode=60108,t.Profiler=60114;var o=60109,i=60110,u=60112;t.Suspense=60113;var s=60115,c=60116;if("function"==typeof Symbol&&Symbol.for){var f=Symbol.for;a=f("react.element"),l=f("react.portal"),t.Fragment=f("react.fragment"),t.StrictMode=f("react.strict_mode"),t.Profiler=f("react.profiler"),o=f("react.provider"),i=f("react.context"),u=f("react.forward_ref"),t.Suspense=f("react.suspense"),s=f("react.memo"),c=f("react.lazy")}var d="function"==typeof Symbol&&Symbol.iterator;function p(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}var y={isMounted:function(){return!1},enqueueForceUpdate:function(){},enqueueReplaceState:function(){},enqueueSetState:function(){}},h={};function g(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}function m(){}function v(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}g.prototype.isReactComponent={},g.prototype.setState=function(e,t){if("object"!=typeof e&&"function"!=typeof e&&null!=e)throw Error(p(85));this.updater.enqueueSetState(this,e,t,"setState")},g.prototype.forceUpdate=function(e){this.updater.enqueueForceUpdate(this,e,"forceUpdate")},m.prototype=g.prototype;var b=v.prototype=new m;b.constructor=v,r(b,g.prototype),b.isPureReactComponent=!0;var M={current:null},E=Object.prototype.hasOwnProperty,L={key:!0,ref:!0,__self:!0,__source:!0};function N(e,t,n){var r,l={},o=null,i=null;if(null!=t)for(r in void 0!==t.ref&&(i=t.ref),void 0!==t.key&&(o=""+t.key),t)E.call(t,r)&&!L.hasOwnProperty(r)&&(l[r]=t[r]);var u=arguments.length-2;if(1===u)l.children=n;else if(1<u){for(var s=Array(u),c=0;c<u;c++)s[c]=arguments[c+2];l.children=s}if(e&&e.defaultProps)for(r in u=e.defaultProps)void 0===l[r]&&(l[r]=u[r]);return{$$typeof:a,type:e,key:o,ref:i,props:l,_owner:M.current}}function w(e){return"object"==typeof e&&null!==e&&e.$$typeof===a}var S=/\/+/g;function x(e,t){return"object"==typeof e&&null!==e&&null!=e.key?function(e){var t={"=":"=0",":":"=2"};return"$"+e.replace(/[=:]/g,(function(e){return t[e]}))}(""+e.key):t.toString(36)}function k(e,t,n,r,o){var i=typeof e;"undefined"!==i&&"boolean"!==i||(e=null);var u=!1;if(null===e)u=!0;else switch(i){case"string":case"number":u=!0;break;case"object":switch(e.$$typeof){case a:case l:u=!0}}if(u)return o=o(u=e),e=""===r?"."+x(u,0):r,Array.isArray(o)?(n="",null!=e&&(n=e.replace(S,"$&/")+"/"),k(o,t,n,"",(function(e){return e}))):null!=o&&(w(o)&&(o=function(e,t){return{$$typeof:a,type:e.type,key:t,ref:e.ref,props:e.props,_owner:e._owner}}(o,n+(!o.key||u&&u.key===o.key?"":(""+o.key).replace(S,"$&/")+"/")+e)),t.push(o)),1;if(u=0,r=""===r?".":r+":",Array.isArray(e))for(var s=0;s<e.length;s++){var c=r+x(i=e[s],s);u+=k(i,t,n,c,o)}else if("function"==typeof(c=function(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=d&&e[d]||e["@iterator"])?e:null}(e)))for(e=c.call(e),s=0;!(i=e.next()).done;)u+=k(i=i.value,t,n,c=r+x(i,s++),o);else if("object"===i)throw t=""+e,Error(p(31,"[object Object]"===t?"object with keys {"+Object.keys(e).join(", ")+"}":t));return u}function j(e,t,n){if(null==e)return e;var r=[],a=0;return k(e,r,"","",(function(e){return t.call(n,e,a++)})),r}function T(e){if(-1===e._status){var t=e._result;t=t(),e._status=0,e._result=t,t.then((function(t){0===e._status&&(t=t.default,e._status=1,e._result=t)}),(function(t){0===e._status&&(e._status=2,e._result=t)}))}if(1===e._status)return e._result;throw e._result}var C={current:null};function I(){var e=C.current;if(null===e)throw Error(p(321));return e}var D={ReactCurrentDispatcher:C,ReactCurrentBatchConfig:{transition:0},ReactCurrentOwner:M,IsSomeRendererActing:{current:!1},assign:r};t.Children={map:j,forEach:function(e,t,n){j(e,(function(){t.apply(this,arguments)}),n)},count:function(e){var t=0;return j(e,(function(){t++})),t},toArray:function(e){return j(e,(function(e){return e}))||[]},only:function(e){if(!w(e))throw Error(p(143));return e}},t.Component=g,t.PureComponent=v,t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=D,t.cloneElement=function(e,t,n){if(null==e)throw Error(p(267,e));var l=r({},e.props),o=e.key,i=e.ref,u=e._owner;if(null!=t){if(void 0!==t.ref&&(i=t.ref,u=M.current),void 0!==t.key&&(o=""+t.key),e.type&&e.type.defaultProps)var s=e.type.defaultProps;for(c in t)E.call(t,c)&&!L.hasOwnProperty(c)&&(l[c]=void 0===t[c]&&void 0!==s?s[c]:t[c])}var c=arguments.length-2;if(1===c)l.children=n;else if(1<c){s=Array(c);for(var f=0;f<c;f++)s[f]=arguments[f+2];l.children=s}return{$$typeof:a,type:e.type,key:o,ref:i,props:l,_owner:u}},t.createContext=function(e,t){return void 0===t&&(t=null),(e={$$typeof:i,_calculateChangedBits:t,_currentValue:e,_currentValue2:e,_threadCount:0,Provider:null,Consumer:null}).Provider={$$typeof:o,_context:e},e.Consumer=e},t.createElement=N,t.createFactory=function(e){var t=N.bind(null,e);return t.type=e,t},t.createRef=function(){return{current:null}},t.forwardRef=function(e){return{$$typeof:u,render:e}},t.isValidElement=w,t.lazy=function(e){return{$$typeof:c,_payload:{_status:-1,_result:e},_init:T}},t.memo=function(e,t){return{$$typeof:s,type:e,compare:void 0===t?null:t}},t.useCallback=function(e,t){return I().useCallback(e,t)},t.useContext=function(e,t){return I().useContext(e,t)},t.useDebugValue=function(){},t.useEffect=function(e,t){return I().useEffect(e,t)},t.useImperativeHandle=function(e,t,n){return I().useImperativeHandle(e,t,n)},t.useLayoutEffect=function(e,t){return I().useLayoutEffect(e,t)},t.useMemo=function(e,t){return I().useMemo(e,t)},t.useReducer=function(e,t,n){return I().useReducer(e,t,n)},t.useRef=function(e){return I().useRef(e)},t.useState=function(e){return I().useState(e)},t.version="17.0.2"},294:(e,t,n)=>{"use strict";e.exports=n(408)},53:(e,t)=>{"use strict";var n,r,a,l;if("object"==typeof performance&&"function"==typeof performance.now){var o=performance;t.unstable_now=function(){return o.now()}}else{var i=Date,u=i.now();t.unstable_now=function(){return i.now()-u}}if("undefined"==typeof window||"function"!=typeof MessageChannel){var s=null,c=null,f=function(){if(null!==s)try{var e=t.unstable_now();s(!0,e),s=null}catch(e){throw setTimeout(f,0),e}};n=function(e){null!==s?setTimeout(n,0,e):(s=e,setTimeout(f,0))},r=function(e,t){c=setTimeout(e,t)},a=function(){clearTimeout(c)},t.unstable_shouldYield=function(){return!1},l=t.unstable_forceFrameRate=function(){}}else{var d=window.setTimeout,p=window.clearTimeout;if("undefined"!=typeof console){var y=window.cancelAnimationFrame;"function"!=typeof window.requestAnimationFrame&&console.error("This browser doesn't support requestAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills"),"function"!=typeof y&&console.error("This browser doesn't support cancelAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills")}var h=!1,g=null,m=-1,v=5,b=0;t.unstable_shouldYield=function(){return t.unstable_now()>=b},l=function(){},t.unstable_forceFrameRate=function(e){0>e||125<e?console.error("forceFrameRate takes a positive int between 0 and 125, forcing frame rates higher than 125 fps is not supported"):v=0<e?Math.floor(1e3/e):5};var M=new MessageChannel,E=M.port2;M.port1.onmessage=function(){if(null!==g){var e=t.unstable_now();b=e+v;try{g(!0,e)?E.postMessage(null):(h=!1,g=null)}catch(e){throw E.postMessage(null),e}}else h=!1},n=function(e){g=e,h||(h=!0,E.postMessage(null))},r=function(e,n){m=d((function(){e(t.unstable_now())}),n)},a=function(){p(m),m=-1}}function L(e,t){var n=e.length;e.push(t);e:for(;;){var r=n-1>>>1,a=e[r];if(!(void 0!==a&&0<S(a,t)))break e;e[r]=t,e[n]=a,n=r}}function N(e){return void 0===(e=e[0])?null:e}function w(e){var t=e[0];if(void 0!==t){var n=e.pop();if(n!==t){e[0]=n;e:for(var r=0,a=e.length;r<a;){var l=2*(r+1)-1,o=e[l],i=l+1,u=e[i];if(void 0!==o&&0>S(o,n))void 0!==u&&0>S(u,o)?(e[r]=u,e[i]=n,r=i):(e[r]=o,e[l]=n,r=l);else{if(!(void 0!==u&&0>S(u,n)))break e;e[r]=u,e[i]=n,r=i}}}return t}return null}function S(e,t){var n=e.sortIndex-t.sortIndex;return 0!==n?n:e.id-t.id}var x=[],k=[],j=1,T=null,C=3,I=!1,D=!1,O=!1;function z(e){for(var t=N(k);null!==t;){if(null===t.callback)w(k);else{if(!(t.startTime<=e))break;w(k),t.sortIndex=t.expirationTime,L(x,t)}t=N(k)}}function A(e){if(O=!1,z(e),!D)if(null!==N(x))D=!0,n(_);else{var t=N(k);null!==t&&r(A,t.startTime-e)}}function _(e,n){D=!1,O&&(O=!1,a()),I=!0;var l=C;try{for(z(n),T=N(x);null!==T&&(!(T.expirationTime>n)||e&&!t.unstable_shouldYield());){var o=T.callback;if("function"==typeof o){T.callback=null,C=T.priorityLevel;var i=o(T.expirationTime<=n);n=t.unstable_now(),"function"==typeof i?T.callback=i:T===N(x)&&w(x),z(n)}else w(x);T=N(x)}if(null!==T)var u=!0;else{var s=N(k);null!==s&&r(A,s.startTime-n),u=!1}return u}finally{T=null,C=l,I=!1}}var P=l;t.unstable_IdlePriority=5,t.unstable_ImmediatePriority=1,t.unstable_LowPriority=4,t.unstable_NormalPriority=3,t.unstable_Profiling=null,t.unstable_UserBlockingPriority=2,t.unstable_cancelCallback=function(e){e.callback=null},t.unstable_continueExecution=function(){D||I||(D=!0,n(_))},t.unstable_getCurrentPriorityLevel=function(){return C},t.unstable_getFirstCallbackNode=function(){return N(x)},t.unstable_next=function(e){switch(C){case 1:case 2:case 3:var t=3;break;default:t=C}var n=C;C=t;try{return e()}finally{C=n}},t.unstable_pauseExecution=function(){},t.unstable_requestPaint=P,t.unstable_runWithPriority=function(e,t){switch(e){case 1:case 2:case 3:case 4:case 5:break;default:e=3}var n=C;C=e;try{return t()}finally{C=n}},t.unstable_scheduleCallback=function(e,l,o){var i=t.unstable_now();switch(o="object"==typeof o&&null!==o&&"number"==typeof(o=o.delay)&&0<o?i+o:i,e){case 1:var u=-1;break;case 2:u=250;break;case 5:u=1073741823;break;case 4:u=1e4;break;default:u=5e3}return e={id:j++,callback:l,priorityLevel:e,startTime:o,expirationTime:u=o+u,sortIndex:-1},o>i?(e.sortIndex=o,L(k,e),null===N(x)&&e===N(k)&&(O?a():O=!0,r(A,o-i))):(e.sortIndex=u,L(x,e),D||I||(D=!0,n(_))),e},t.unstable_wrapCallback=function(e){var t=C;return function(){var n=C;C=t;try{return e.apply(this,arguments)}finally{C=n}}}},840:(e,t,n)=>{"use strict";e.exports=n(53)},188:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(151);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},413:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(148);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},810:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(908);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},454:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(174);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},379:(e,t,n)=>{"use strict";var r,a=function(){var e={};return function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}e[t]=n}return e[t]}}(),l=[];function o(e){for(var t=-1,n=0;n<l.length;n++)if(l[n].identifier===e){t=n;break}return t}function i(e,t){for(var n={},r=[],a=0;a<e.length;a++){var i=e[a],u=t.base?i[0]+t.base:i[0],s=n[u]||0,c="".concat(u," ").concat(s);n[u]=s+1;var f=o(c),d={css:i[1],media:i[2],sourceMap:i[3]};-1!==f?(l[f].references++,l[f].updater(d)):l.push({identifier:c,updater:h(d,t),references:1}),r.push(c)}return r}function u(e){var t=document.createElement("style"),r=e.attributes||{};if(void 0===r.nonce){var l=n.nc;l&&(r.nonce=l)}if(Object.keys(r).forEach((function(e){t.setAttribute(e,r[e])})),"function"==typeof e.insert)e.insert(t);else{var o=a(e.insert||"head");if(!o)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");o.appendChild(t)}return t}var s,c=(s=[],function(e,t){return s[e]=t,s.filter(Boolean).join("\n")});function f(e,t,n,r){var a=n?"":r.media?"@media ".concat(r.media," {").concat(r.css,"}"):r.css;if(e.styleSheet)e.styleSheet.cssText=c(t,a);else{var l=document.createTextNode(a),o=e.childNodes;o[t]&&e.removeChild(o[t]),o.length?e.insertBefore(l,o[t]):e.appendChild(l)}}function d(e,t,n){var r=n.css,a=n.media,l=n.sourceMap;if(a?e.setAttribute("media",a):e.removeAttribute("media"),l&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(l))))," */")),e.styleSheet)e.styleSheet.cssText=r;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(r))}}var p=null,y=0;function h(e,t){var n,r,a;if(t.singleton){var l=y++;n=p||(p=u(t)),r=f.bind(null,n,l,!1),a=f.bind(null,n,l,!0)}else n=u(t),r=d.bind(null,n,t),a=function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(n)};return r(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap)return;r(e=t)}else a()}}e.exports=function(e,t){(t=t||{}).singleton||"boolean"==typeof t.singleton||(t.singleton=(void 0===r&&(r=Boolean(window&&document&&document.all&&!window.atob)),r));var n=i(e=e||[],t);return function(e){if(e=e||[],"[object Array]"===Object.prototype.toString.call(e)){for(var r=0;r<n.length;r++){var a=o(n[r]);l[a].references--}for(var u=i(e,t),s=0;s<n.length;s++){var c=o(n[s]);0===l[c].references&&(l[c].updater(),l.splice(c,1))}n=u}}}}},t={};function n(r){var a=t[r];if(void 0!==a)return a.exports;var l=t[r]={id:r,exports:{}};return e[r](l,l.exports,n),l.exports}n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{"use strict";var e=n(294),t=n(935),r=n(490),a={pub:function(e){a.subs[e]||(a.subs[e]=[]),a.subs[e].forEach((function(e){return e()}))},sub:function(e,t){a.subs[e]||(a.subs[e]=[]),a.subs[e].push(t)},subs:{}};$(document).ready((function(){$("body").append($('<div id="cookie-consent"></div>')),t.render(e.createElement(r.Z,{dispatcher:a}),document.getElementById("cookie-consent"))})),window.plosCookieConsentBanner={reopen:function(){a.pub("open")}}})()})(); </script>  <script type="text/javascript" src="https://biologue.plos.org/wp-includes/js/comment-reply.min.js?ver=6.6.2" id="comment-reply-js" async="async" data-wp-strategy="async"></script> <script type="text/javascript" src="https://biologue.plos.org/wp-content/plugins/plos-elementor-widgets/assets/js/widgets.js?ver=0.0.1" id="plos-elementor-js"></script> <script type="text/javascript" src="https://biologue.plos.org/wp-content/plugins/plos-elementor-widgets/assets/lib/slick-1.8.1/slick/slick.js?ver=1.8.1" id="slick-js"></script> <script type="text/javascript" src="https://biologue.plos.org/wp-content/themes/plos/dist/scripts/main_2eafddd7.js?ver=0.0.8" id="sage/main.js-js"></script>  <script> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='//static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('init','o5hg7'); twq('track','PageView'); </script>  </body> </html>

CINXE.COM

PLOS Biologue - The blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.