Antibody Function Assays - Creative Biolabs

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Their exceptional precision and strength in binding to specific antigens enable highly effective treatments with minimal side effects. Additionally, the flexibility in their structure and functions allows for a diverse range of therapeutic applications and targets. With the advancement of engineering technologies, antibodies can be modified for improved efficacy, underscoring the importance of thoroughly understanding their functions and therapeutic potential for advancing immunotherapy. </p> <p class="serviceshowpic"> <img loading="lazy" src="images/3-4-1-antibody-functional-assays-1.jpg" width="650" height="" alt="Fig.1 Effector mechanisms of therapeutic mAbs in cancer therapy. (Rodr铆guez-Nava, et al., 2023)" />Fig.1 The immune responses induced by therapeutic monoclonal antibodies in cancer treatment.<sup>1, 4</sup> </p> <h3> Antibody Function Assays at Creative Biolabs </h3> <p> Therapeutic antibodies leverage diverse mechanisms of action like receptor blocking, receptor activation, and immune cell-mediated killing processes for targeting diseases. This necessitates a varied approach to evaluate these functions and enhance antibody performance through engineering methods. </p> <p> At <strong>Creative Biolabs</strong>, we take pride in offering an extensive range of assays designed to assess the functionality of antibody-based therapeutics. Our assays focus on key antibody mechanisms, including Fab-based antigen-antibody binding and Fc-based antibody function. Leveraging our advanced research platforms and experienced team, we are well-equipped to assist customers worldwide in developing and executing optimal project schemes with high effectiveness and reliability. We are committed to providing proven project results that enable thorough characterization of antibody function and facilitate the selection of promising candidates during the discovery phase. </p> <h3> Services Package </h3> <ul class="ullist"> <li> <a href="/drug-discovery/therapeutics/target-binding-based-function-analysis-characterization.htm"><strong>Target Binding-based Function Analysis & Characterization</strong></a>: The variable domain of an antibody is a crucial region responsible for binding to antigens. It contains the paratope, which is comprised of complementarity-determining regions (CDRs) that are essential for antigen recognition. </li> </ul> <p class="serviceshowpic"> <img loading="lazy" src="images/3-4-1-antibody-functional-assays-2.jpg" width="600" height="420" alt="Fig.2 Various local microenvironment and physiological factors influence antibody-target engagement in vivo. (Dunlap & Yanguang, 2022)" />Fig.2 Representation of factors influencing antibody targeting in the biological environment.<sup>2, 5</sup> </p> <p> We utilize a variety of assay formats and technical methods to properly understand the characteristics of the variable domain, including: </p> <div class="table-responsive"> <table style="margin-right:auto;margin-left:auto;max-width:100%;" class="table table-bordered table-condensed"> <tbody> <tr> <th width="15%"> <strong>Services</strong> </th> <th width="35%"> <strong>Overview</strong> </th> <th width="15%"> <strong>Services</strong> </th> <th width="35%"> <strong>Overview</strong> </th> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/binding-assays.htm">Antibody Binding Assays</a></strong> </td> <td> Combined with numerous state-of-the-art techniques, we globally provide multiple assay formats such as <a href="/drug-discovery/therapeutics/cell-based-binding-assay.htm">cell-</a> or <a href="/drug-discovery/therapeutics/ligand-binding-assay.htm">non-cell-</a>based binding assays, <a href="/drug-discovery/therapeutics/antibody-cross-reactivity-testing.htm">antibody cross-reactivity examing</a>, <em>etc</em>., to advance antibody drug discovery and development. </td> <td> <a href="/drug-discovery/therapeutics/in-vitro-cellular-senescence-assay.htm"><strong><em>In Vitro</em> Cellular Senescence Assay</strong></a> </td> <td> Unlock the secrets of cellular aging with our cutting-edge cellular senescence assay, which utilizes 尾-gal activity detection methods to provide valuable insights. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/cell-proliferation-assessment.htm">Cellular Proliferation Assays</a></strong> </td> <td> Our proliferation assays provide valuable insights into the cytotoxic effects of antibodies, aiding in assessing therapeutic consequences and pharmacological safety. </td> <td> <a href="/drug-discovery/therapeutics/parp-assay.htm"><strong>PARP Assay</strong></a> </td> <td> Our PARP assay services are designed to support the discovery of PARP-targeted therapeutics for cancer treatment. We offer comprehensive testing to aid cancer research efforts. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/apoptosis-and-programmed-cell-death-assessment.htm">Cellular Apoptosis Assays</a></strong> </td> <td> Our high-throughput caspase screening assays provide valuable insights into the mechanisms of cell death mediated by antibodies, helping to identify specific pathways involved in apoptosis and better understand their impact on target cells. </td> <td> <a href="/drug-discovery/therapeutics/in-situ-microrna-detection-service.htm"><strong><em>In Situ</em> MicroRNA Detection Service</strong></a> </td> <td> We utilize fluorescence <em>in situ</em> hybridization (FISH) to analyze miRNA expression <em>in situ</em> </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/neutralization-assay.htm">Neutralization Assays</a></strong> </td> <td> Our neutralization assays provide a comprehensive platform to evaluate and quantify the neutralization potential of antibodies against a range of pathogens, cytokines, toxins, and other targets, allowing for tailored assay formats to suit your specific research needs. </td> <td> <a href="/drug-discovery/therapeutics/in-vitro-cell-based-a-synuclein-aggregation-assay.htm"><strong><em>In Vitro</em> Cell-based 伪-synuclein Aggregation Assay Service</strong></a> </td> <td> We leverage apoptosis induction to stimulate the formation of 伪-synuclein aggregates, enabling the measurement of 伪-synuclein expression and aggregation levels, which can inform the development of therapeutic strategies. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/receptor-function-study.htm">Antibody-Receptor Function Studies</a></strong> </td> <td> In our antibody-receptor functional analysis services, we evaluate interactions with immune checkpoints and G protein-coupled receptors (GPCRs) to improve immunotherapy strategies. </td> <td> <a href="/drug-discovery/therapeutics/in-vitro-cellular-phosphorylation-assay.htm"><strong><em>In Vitro</em> Cellular Phosphorylation Assay Service</strong></a> </td> <td> Our assay efficiently measures phosphorylation levels by leveraging endogenously expressed target kinases in cells or utilizing cells engineered for overexpression of the specific kinase under study. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/endocytosis-and-internalization-potency-detection.htm">Endocytosis and Internalization Assays</a></strong> </td> <td> The internalization process is important for maintaining cell function and can be studied for understanding diseases and developing new therapies. We offer cutting-edge techniques to investigate and manipulate internalization processes for research purposes </td> <td> <a href="/drug-discovery/therapeutics/in-vitro-cell-based-phospholipidosis-assay.htm"><strong><em>In Vitro</em> Cell-based Phospholipidosis Assay Service</strong></a> </td> <td> We offer a cell-based assay that utilizes a fluorescent dye to quantify PLD changes in cells. By observing fluorescence intensity changes, we can rapidly examine compounds for their potential to induce phospholipidosis. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/angiogenesis-investigation.htm">Angiogenesis Investigation</a></strong> </td> <td> Our angiogenesis investigation services pay the way for tumor progression and metastasis research involving <a href="/drug-discovery/therapeutics/tube-formation-assay.htm">tube formation</a>, <a href="/drug-discovery/therapeutics/cell-migration-assay.htm">cell migration</a>, <a href="/drug-discovery/therapeutics/in-vitro-cell-adhesion-assay.htm">cell adhesion</a>, <em>etc</em>. </td> <td> </td> <td> </td> </tr> </tbody> </table> </div> <ul class="ullist"> <li> <a href="/drug-discovery/therapeutics/fc-based-function-analysis-characterization.htm"><strong>Fc-based Function Analysis & Characterization</strong></a><strong>: </strong>The Fc region of an antibody is crucial for modulating immune responses and enhancing efficacy. It consists of heavy chains that bind to specific Fc receptors and immune molecules, allowing antibodies to mediate various biological functions.<strong></strong> </li> </ul> <p class="serviceshowpic"> <img loading="lazy" src="images/3-4-1-antibody-functional-assays-3.jpg" width="650" height="326" alt="Fig.3 Immunomodulation mediated by antibody Fc region. (Van Erp, et al., 2019)" />Fig.3 Antibody Fc-mediated immunomodulation.<sup>3, 5</sup> </p> <p> Creative Biolabs specializes in evaluating and optimizing Fc regions, including glycosylation, to improve safety and efficacy. Our advanced technology platforms enable tailored engineering strategies for optimizing antibody function. Our services include: </p> <div class="table-responsive"> <table style="margin-right:auto;margin-left:auto;max-width:100%;" class="table table-bordered table-condensed"> <tbody> <tr> <th width="15%"> <strong>Services</strong> </th> <th> <strong>Overview</strong> </th> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/immune-effector-functions-assays.htm">Fc-mediated Effector Functions</a></strong> </td> <td> We specialize in analyzing and interpreting the cytotoxic effects of candidates using ADCC, CDC, and ADCP assays. Additionally, we offer non-cell-based assays to characterize antibody products with Fc纬 receptor binding capabilities and assess binding affinity to complement component C1q. </td> </tr> <tr> <td> <strong><a href="/drug-discovery/therapeutics/fc-engineering-service.htm">Fc Engineering</a></strong> </td> <td> Creative Biolabs provides services for Fc engineering to fine-tune antibody properties and enhance efficacy. This includes antibody skeleton engineering and Fc glycoengineering, optimizing effector functions for improved therapeutic outcomes. </td> </tr> </tbody> </table> </div> <h3> Highlights of Our services </h3> <ul class="ullist"> <li> Extensive antibody research expertise and experience. </li> <li> Highly effective and reproducible. </li> <li> Rapid timelines. </li> <li> Standardized report delivery. </li> <li> End-to-end comprehensive services. </li> </ul> <h3> Frequently Asked Questions </h3> <p> <strong>Q1: What sets a binding assay apart from a functional assay?</strong> </p> <p> A1: It is important to distinguish between the functional activity and binding activity of antibodies. While binding activity refers to the ability of an antibody to bind to its target antigen, functional activity pertains to the biological effects it induces, such as cell signaling or immune response modulation. Functional assays are designed to assess the specific biological impact of an antibody, providing crucial insights into its therapeutic potential. </p> <p> <strong>Q2: What are the requirements for antibody function assays?</strong> </p> <p> A2: To conduct antibody functional assays, we need customers to provide basic information about your candidate samples, such as name, molecular weight, <em>etc</em>. Different assays have different sample submission requirements. We provide one-on-one consulting services to ensure that your project goes smoothly. Please reach out to our team if you require any specific accommodations or assistance. </p> <p> Want to know more about your antibodies'? Please contact us with your meaningful projects. </p> <p class="Reference"> <strong>References</strong> </p> <ol class="ollist Reference"> <li> Rodr铆guez-Nava, Cynthia, et al. "Mechanisms of action and limitations of monoclonal antibodies and single chain fragment variable (scFv) in the treatment of cancer." <em>Biomedicines </em>11.6 (2023): 1610. </li> <li> Dunlap, Tyler, and Yanguang Cao. "Physiological considerations for modeling <em>in vivo</em> antibody-target interactions." <em>Frontiers in Pharmacology</em> 13 (2022): 856961. </li> <li> Van Erp, Elisabeth A., et al. "Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease." <em>Frontiers in Immunology</em> 10 (2019): 548. </li> <li> under Open Access License <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="nofollow noopener norefferrer">CC BY 4.0</a>. The original image was modified by hiding certain words, and the title was changed to " The immune responses induced by therapeutic monoclonal antibodies in cancer treatment". </li> <li> under Open Access License <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="nofollow noopener norefferrer">CC BY 4.0</a>, without modification. </li> </ol> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [{ "@type": "Question", "name": "What sets a binding assay apart from a functional assay?", "acceptedAnswer": { "@type": "Answer", "text": "It is important to distinguish between the functional activity and binding activity of antibodies. While binding activity refers to the ability of an antibody to bind to its target antigen, functional activity pertains to the biological effects it induces, such as cell signaling or immune response modulation. Functional assays are designed to assess the specific biological impact of an antibody, providing crucial insights into its therapeutic potential." } },{ "@type": "Question", "name": "What are the requirements for antibody function assays?", "acceptedAnswer": { "@type": "Answer", "text": "To conduct antibody functional assays, we need customers to provide basic information about your candidate samples, such as name, molecular weight, etc. Different assays have different sample submission requirements. We provide one-on-one consulting services to ensure that your project goes smoothly. 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