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KEGG ORTHOLOGY: K14256
<!doctype html> <html><head> <title>KEGG ORTHOLOGY: K14256</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743401678"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743401678"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743401678" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg4.gif"></a></td><td> </td><td><a name="orthology:K14256"></a><font class="title4">ORTHOLOGY: K14256</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_ko.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr4 w1"> <table width="650" class="w2"> <tr><th class="th40 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td40 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">K14256 KO <br> </span></code></td></tr></table></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Symbol</span></th> <td class="td41 defd"><div class="cel">oxyS, cts8<br> </div></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td40 defd"><div class="cel"><div class="cel">anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:<a href="/entry/1.14.13.38">1.14.13.38</a> <a href="/entry/1.14.13.234">1.14.13.234</a>]<br> </div></div></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td41 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00253+K14256">map00253</a> </span></td><td>Tetracycline biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01057+K14256">map01057</a> </span></td><td>Biosynthesis of type II polyketide products</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01100+K14256">map01100</a> </span></td><td>Metabolic pathways</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01110+K14256">map01110</a> </span></td><td>Biosynthesis of secondary metabolites</td></tr></table></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Module</span></th> <td class="td40 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00780+K14256">M00780</a> </span></td><td>Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00823+K14256">M00823</a> </span></td><td>Chlortetracycline biosynthesis, pretetramide => chlortetracycline</td></tr></table></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Reaction</span></th> <td class="td41 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R04060">R04060</a> </span></td><td>anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R09198">R09198</a> </span></td><td>5a,11a-dehydrotetracycline,NADPH:oxygen oxidoreductase (5-hydroxylating)</td></tr></table></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td40 defd"><div class="cel"><span class="nowrap">KEGG Orthology (KO) [BR:<a href="/brite/ko00001+K14256">ko00001</a>]<br> 09100 Metabolism<br> 09109 Metabolism of terpenoids and polyketides<br> 01057 Biosynthesis of type II polyketide products<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> 00253 Tetracycline biosynthesis<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> 09180 Brite Hierarchies<br> 09181 Protein families: metabolism<br> 01008 Polyketide biosynthesis proteins<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> Enzymes [BR:<a href="/brite/ko01000+K14256">ko01000</a>]<br> 1. Oxidoreductases<br> 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen<br> 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor<br> 1.14.13.38 anhydrotetracycline 6-monooxygenase<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> 1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> Polyketide biosynthesis proteins [BR:<a href="/brite/ko01008+K14256">ko01008</a>]<br> Polyketide tailoring proteins<br> Oxygenase<br> K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=K14256';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td41 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">GO: </span></td><td><a href="http://amigo.geneontology.org/amigo/term/GO:0047670">0047670</a></td></tr></table></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td40 defd"><style>.g1{display:none;}</style><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SVR: </span></td><td><a href="/entry/svr:CP971_23960">CP971_23960</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SRIM: </span></td><td><a href="/entry/srim:CP984_02460">CP984_02460</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SPLA: </span></td><td><a href="/entry/spla:CP981_34445">CP981_34445</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SDRZ: </span></td><td><a href="/entry/sdrz:NEH16_31700">NEH16_31700</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SHAU: </span></td><td><a href="/entry/shau:K9S39_12950">K9S39_12950</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SARM: </span></td><td><a href="/entry/sarm:DVA86_06945">DVA86_06945</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SCAJ: </span></td><td><a href="/entry/scaj:O1G22_08880">O1G22_08880</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SCHE: </span></td><td><a href="/entry/sche:QRN89_14740">QRN89_14740</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">STRV: </span></td><td><a href="/entry/strv:EZV63_00255">EZV63_00255</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">KAU: </span></td><td><a href="/entry/kau:B6264_18535">B6264_18535</a></td></tr></table><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NEX: </span></td><td><a href="/entry/nex:NE857_24350">NE857_24350</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">AGRA: </span></td><td><a href="/entry/agra:AGRA3207_005105">AGRA3207_005105</a> <a href="/entry/agra:AGRA3207_005106">AGRA3207_005106</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">AORI: </span></td><td><a href="/entry/aori:SD37_34210">SD37_34210</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">KUT: </span></td><td><a href="/entry/kut:JJ691_15570">JJ691_15570</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CROS: </span></td><td><a href="/entry/cros:N8J89_05295">N8J89_05295</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">DAUR: </span></td><td><a href="/entry/daur:Daura_37815">Daura_37815</a> <a href="/entry/daur:Daura_37840">Daura_37840</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CCAZ: </span></td><td><a href="/entry/ccaz:COUCH_15960">COUCH_15960</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">AG: </span></td><td><a href="/entry/ag:AAZ78342">AAZ78342</a>(oxyS) <a href="/entry/ag:AEI98657">AEI98657</a>(ctcN) <a href="/entry/ag:BAA07387">BAA07387</a>(cts8)</td></tr></table></div><a href="javascript:void(0)" onclick="javascript:toggleField(this,"g1","show all","hide")"> » show all</a><br> <button class="btn" onclick="location.href='/kegg-bin/show_taxonomy?ko=K14256';return false;">Taxonomy</button><button class="btn" onclick="location.href='/kegg-bin/uniprot_list?ko=K14256';return false;">UniProt</button></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td41 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16597959">16597959</a></div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td40 repd"><div class="cel">Zhang W, Ames BD, Tsai SC, Tang Y</div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td41 repd"><div class="cel">Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.</div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td40 repd"><div class="cel">Appl Environ Microbiol 72:2573-80 (2006)<br>DOI:<a href="https://doi.org/10.1128/AEM.72.4.2573-2580.2006">10.1128/AEM.72.4.2573-2580.2006</a></div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td41 repd"><div class="cel">[ag:<a href="/entry/ag:AAZ78342">AAZ78342</a>]</div></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td40 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16148009">16148009</a></div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td41 repd"><div class="cel">Peric-Concha N, Borovicka B, Long PF, Hranueli D, Waterman PG, Hunter IS</div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td40 repd"><div class="cel">Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.</div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td41 repd"><div class="cel">J Biol Chem 280:37455-60 (2005)<br>DOI:<a href="https://doi.org/10.1074/jbc.M503191200">10.1074/jbc.M503191200</a></div></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td40 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23621493">23621493</a></div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td41 repd"><div class="cel">Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y</div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td40 repd"><div class="cel">Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.</div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td41 repd"><div class="cel">J Am Chem Soc 135:7138-41 (2013)<br>DOI:<a href="https://doi.org/10.1021/ja403516u">10.1021/ja403516u</a></div></td></tr> <tr><th class="th40 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td40 defd"><button class="btn" 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