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class="right-wrapper col-narrow-8 col-normal-8 col-mobile-12 toc-pane"> <div class="panel-panel panel-region-main"> <div class="inside"><div class="panel-pane pane-custom pane-1 pane-page-title-suffix" > <div class="pane-content"> <h3>June 2023 - Volume 8 - 3</h3> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div class="issue-toc"><div class="issue-toc-section issue-toc-section-editorials"><h2 id="Editorials" class="toc-heading editorials">Editorials</h2><ul class="toc-section"><li class="first odd toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5876" data-node-nid="5876" id="node-5876--21218364267" data-pisa="svnbmj;8/3/175" data-pisa-master="svnbmj;svn-2022-002049" data-apath="/svnbmj/8/3/175.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/175" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Editorial: minor stroke is not minor</span></a> (15 December, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Xinyi</span> <span class="nlm-surname">Leng</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">David</span> <span class="nlm-surname">Wang</span></span></span></div> </div> </div></div></li><li class="last even toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5869" data-node-nid="5869" id="node-5869--22085500256" data-pisa="svnbmj;8/3/178" data-pisa-master="svnbmj;svn-2022-002080" data-apath="/svnbmj/8/3/178.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/178" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">COP27 climate change conference: urgent action needed for Africa and the world</span></a> (18 October, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Chris</span> <span class="nlm-surname">Zielinski</span></span></span></div> </div> </div></div></li></ul></div><div class="issue-toc-section issue-toc-section-original-research"><h2 id="Originalresearch" class="toc-heading original-research">Original research</h2><ul class="toc-section"><li class="first odd toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5867" data-node-nid="5867" id="node-5867--21518680765" data-pisa="svnbmj;8/3/181" data-pisa-master="svnbmj;svn-2022-001498" data-apath="/svnbmj/8/3/181.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/181" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">MALAT1 promotes platelet activity and thrombus formation through PI3k/Akt/GSK-3尾 signalling pathway</span></a> (14 October, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Yeying</span> <span class="nlm-surname">Sun</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Tao</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Yan</span> <span class="nlm-surname">Lv</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Jiahua</span> <span class="nlm-surname">Li</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Xiaoli</span> <span class="nlm-surname">Jiang</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Jing</span> <span class="nlm-surname">Jiang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Daolai</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Weihua</span> <span class="nlm-surname">Bian</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Chunxiang</span> <span class="nlm-surname">Zhang</span></span></span></div> </div> </div></div></li><li class="even toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5865" data-node-nid="5865" id="node-5865--21725637541" data-pisa="svnbmj;8/3/194" data-pisa-master="svnbmj;svn-2022-001639" data-apath="/svnbmj/8/3/194.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/194" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Aetiology of extracranial carotid free-floating thrombus in a prospective multicentre cohort</span></a> (11 November, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Dar</span> <span class="nlm-surname">Dowlatshahi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Cheemun</span> <span class="nlm-surname">Lum</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Bijoy K</span> <span class="nlm-surname">Menon</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Aditya</span> <span class="nlm-surname">Bharatha</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Prasham</span> <span class="nlm-surname">Dave</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Paulo</span> <span class="nlm-surname">Puac-Polanco</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Dylan</span> <span class="nlm-surname">Blacquiere</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Grant</span> <span class="nlm-surname">Stotts</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Michel</span> <span class="nlm-surname">Shamy</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Franco</span> <span class="nlm-surname">Momoli</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Rebecca</span> <span class="nlm-surname">Thornhill</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">Ronda</span> <span class="nlm-surname">Lun</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">Carlos</span> <span class="nlm-surname">Torres</span></span></span></div> </div> </div></div></li><li class="odd toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5868" data-node-nid="5868" id="node-5868--2231252361" data-pisa="svnbmj;8/3/197" data-pisa-master="svnbmj;svn-2022-001700" data-apath="/svnbmj/8/3/197.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/197" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-尾/BMP-SMAD4 pathway</span></a> (23 November, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Hongyuan</span> <span class="nlm-surname">Xu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Ran</span> <span class="nlm-surname">Huo</span></span>, <span 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class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Qiheng</span> <span class="nlm-surname">He</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Yingfan</span> <span class="nlm-surname">Sun</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">Shuo</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">Yong</span> <span class="nlm-surname">Cao</span></span></span></div> </div> </div></div></li><li class="even toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5870" data-node-nid="5870" id="node-5870--2702793941" data-pisa="svnbmj;8/3/207" data-pisa-master="svnbmj;svn-2022-001583" data-apath="/svnbmj/8/3/207.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a 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class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/229" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke: results from the MR CLEAN Registry</span></a> (26 December, 2022) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Sabine L</span> <span class="nlm-surname">Collette</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Michael P</span> <span class="nlm-surname">Rodgers</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Marianne A A</span> <span class="nlm-surname">van Walderveen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Kars C J</span> <span class="nlm-surname">Compagne</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Paul J</span> <span class="nlm-surname">Nederkoorn</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Jeannette</span> <span class="nlm-surname">Hofmeijer</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Jasper M</span> <span class="nlm-surname">Martens</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Gert J</span> <span class="nlm-surname">de Borst</span></span>, <span class="highwire-citation-author" 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data-delta="12"><span class="nlm-given-names">Deng-Ji</span> <span class="nlm-surname">Pan</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">Jian-Ping</span> <span class="nlm-surname">Hu</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">Xiang</span> <span class="nlm-surname">Luo</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">Sha-Bei</span> <span class="nlm-surname">Xu</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">Wei</span> <span class="nlm-surname">Wang</span></span></span></div> </div> </div></div></li></ul></div><div class="issue-toc-section issue-toc-section-protocol"><h2 id="Protocol" class="toc-heading protocol">Protocol</h2><ul class="toc-section"><li class="first last odd toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5871" data-node-nid="5871" id="node-5871--21754833449" data-pisa="svnbmj;8/3/249" data-pisa-master="svnbmj;svn-2022-002084" data-apath="/svnbmj/8/3/249.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-toc clearfix"> <a href="/content/8/3/249" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Rationale and design of a randomised double-blind 2脳2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)</span></a> (27 January, 2023) <span class="highwire-cite-access"><span class="highwire-citation-access"><svg class="icon icon-open-access bmjj-open-access bmjj-access-tag"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-openaccess"></use><svg></svg></svg></span></span> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ying</span> <span class="nlm-surname">Gao</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Yuesong</span> <span class="nlm-surname">Pan</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Shangrong</span> <span class="nlm-surname">Han</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Weiqi</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Jing</span> <span class="nlm-surname">Jing</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Chunjuan</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Yingying</span> <span class="nlm-surname">Yang</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Tingting</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Xia</span> <span class="nlm-surname">Meng</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Xingquan</span> <span class="nlm-surname">Zhao</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Liping</span> <span class="nlm-surname">Liu</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">Hao</span> <span class="nlm-surname">Li</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">S Claiborne</span> <span class="nlm-surname">Johnston</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">Pierre</span> <span class="nlm-surname">Amarenco</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">Philip M</span> <span class="nlm-surname">Bath</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">Yongjun</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">Yilong</span> <span class="nlm-surname">Wang</span></span></span></div> </div> </div></div></li></ul></div><div class="issue-toc-section issue-toc-section-brief-report"><h2 id="Briefreport" class="toc-heading brief-report">Brief report</h2><ul class="toc-section"><li class="first last odd toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node5874" data-node-nid="5874" id="node-5874--21972388208" 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data-delta="1"><span class="nlm-given-names">Quanhe</span> <span class="nlm-surname">Yang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Ganesh</span> <span class="nlm-surname">Asaithambi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Robert K</span> <span class="nlm-surname">Merritt</span></span></span></div> </div> </div></div></li></ul></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-variant-list" id="issue-information"> <h2 class="pane-title">Issue Information</h2> <div class="pane-content"> <ul class="links variants-list inline"><li class="tocpdf first"><a href="/content/8/3.toc.pdf" class="highwire-variant-link variant-tocpdf " title="Table of Contents (PDF)" rel="alternate" type="application/pdf" data-icon-position="" data-hide-link-title="0">Table of Contents (PDF) </a></li> <li class="cover-expansion"><a 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