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</li> <li id="toc-Otkriće" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Otkriće"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Otkriće</span> </div> </a> <ul id="toc-Otkriće-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Struktura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Struktura"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Struktura</span> </div> </a> <ul id="toc-Struktura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Funkcija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Funkcija"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Funkcija</span> </div> </a> <ul id="toc-Funkcija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Klinički_značaj" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Klinički_značaj"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Klinički značaj</span> </div> </a> <ul id="toc-Klinički_značaj-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaži/sakrij sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaži/sakrij sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading" lang="sh-Latn" dir="ltr"><span class="mw-page-title-main">Interleukin 28</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prijedi na druge jezične varijante članka. Dostupno je na 3 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-3" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">3 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin_28" title="Interleukin 28 — Engleski" lang="en" hreflang="en" data-title="Interleukin 28" data-language-autonym="English" data-language-local-name="Engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_28" title="Interleukina 28 — Poljski" lang="pl" hreflang="pl" data-title="Interleukina 28" data-language-autonym="Polski" data-language-local-name="Poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_28" title="Интерлеукин 28 — Srpski" lang="sr" hreflang="sr" data-title="Интерлеукин 28" data-language-autonym="Српски / srpski" data-language-local-name="Srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q24787633#sitelinks-wikipedia" title="Uredi međujezične poveznice" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin_28" title="Vidi stranicu sadržaja [c]" accesskey="c"><span>Stranica</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Razgovor:Interleukin_28" rel="discussion" title="Razgovarajte o sadržini ove stranice [t]" accesskey="t"><span>Razgovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Promijeni jezičnu varijantu" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Latinica</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-sh-Latn mw-list-item"><a href="/w/index.php?title=Interleukin_28&variant=sh-latn" lang="sh-Latn" hreflang="sh-Latn"><span>Latinica</span></a></li><li id="ca-varlang-1" class="ca-variants-sh-Cyrl mw-list-item"><a href="/w/index.php?title=Interleukin_28&variant=sh-cyrl" lang="sh-Cyrl" hreflang="sh-Cyrl"><span>Ћирилица</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Teme"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin_28"><span>Prikaži</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin_28&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin_28&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi kod</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin_28&action=history" title="Pogledajte prethodne verzije ove stranice [h]" accesskey="h"><span>Historija</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Alatke" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Alatke</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Alati</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">sakrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Više mogućnosti" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Radnje </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interleukin_28"><span>Prikaži</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin_28&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin_28&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi kod</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin_28&action=history"><span>Historija</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Opšte </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:%C5%A0to_vodi_ovdje/Interleukin_28" title="Pogledajte listu svih stranica koje vode ovamo [j]" accesskey="j"><span>Šta vodi ovamo</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:Povezane_izmjene/Interleukin_28" rel="nofollow" title="Prelistajte nedavne izmjene stranica koje su povezane s ovom [k]" accesskey="k"><span>Povezane izmjene</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:Posebne_stranice" title="Pregledajte listu svih posebnih stranica [q]" accesskey="q"><span>Posebne stranice</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Interleukin_28&oldid=5003013" title="Nabavite trajnu vezu do ove verzije stranice"><span>Trajna veza</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Interleukin_28&action=info" title="Pronađite više informacija o ovoj stranici"><span>Podaci o stranici</span></a></li><li id="t-cite" 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href="/w/index.php?title=Posebno:Kolekcija&bookcmd=book_creator&referer=Interleukin+28"><span>Napravi knjigu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Posebno:DownloadAsPdf&page=Interleukin_28&action=show-download-screen"><span>Preuzmi kao PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Interleukin_28&printable=yes" title="Odštampajte ovu stranicu [p]" accesskey="p"><span>Odštampaj</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Na drugim projektima </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q24787633" title="Pogledajte povezanu stavku u skladištu podataka [g]" accesskey="g"><span>Stavka na Wikipodacima</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Izgled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Izgled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">sakrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Izvor: Wikipedija</div> </div> <div id="contentSub" lang="sh-Latn" dir="ltr"><div id="mw-content-subtitle" lang="sh-Latn" dir="ltr"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sh-Latn" dir="ltr"><table style="background:transparent; float:right; margin:0; padding:0;"> <tbody><tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 28A </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL28A </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, IFNL2 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=282616&rn=1">282616</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=18364">18364</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607401&rn=1">607401</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NM_172138&rn=1">NM_172138</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q8IZJ0">Q8IZJ0</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_19_(%C4%8Dovek)" title="Hromozom 19 (čovek)">Hrom. 19</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=19q13.13">q13.13</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 28B </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL28B </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, IFNL3 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=282617&rn=1">282617</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=18365">18365</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607402&rn=1">607402</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NM_172139&rn=1">NM_172139</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q8IZI9">Q8IZI9</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_19_(%C4%8Dovek)" title="Hromozom 19 (čovek)">Hrom. 19</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=19q13.13">q13.13</a></i> </td></tr> </tbody></table> </td></tr></tbody></table> <p><b>Interleukin 28</b> (IL-28) je <a href="/wiki/Citokin" title="Citokin">citokin</a> koji ima dve <a href="/wiki/Izoforma" class="mw-redirect" title="Izoforma">izoforme</a>, IL-28A i IL-28B, i igra ulogu u imunoj odbrani protiv <a href="/wiki/Virus" class="mw-disambig" title="Virus">virusa</a>, uključujući indukciju „antivirusnog stanja“ putem uključivanja Mx proteina, <a href="/w/index.php?title=OAS1&action=edit&redlink=1" class="new" title="OAS1 (stranica ne postoji)">2',5'-oligoadenilat sintetaze</a> kao i <a href="/w/index.php?title=ISGF3G&action=edit&redlink=1" class="new" title="ISGF3G (stranica ne postoji)">ISGF3G</a> (Interferon Stimulisanog Gen Faktora 3).<sup id="cite_ref-pmid15171810_1-0" class="reference"><a href="#cite_note-pmid15171810-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> IL-28A i IL-28B pripadaju <a href="/wiki/Interferon_tip_III" title="Interferon tip III">tip III</a> <a href="/wiki/Interferon" title="Interferon">interferon</a> familiji citokina i veoma su slični (po <a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiselinskoj</a> sekvenci) sa <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a>. NJihova klasifikacija kao interferoni je usled njihove sposobnosti da indukuju antiviralno stanje, dok je njihova dodatna klasifikacija kao citokini usled njihove hromozomske lokacije kao i činjenice da su oni kodirani sa više eksona, što je u suprotnosti sa jednim eksonom kao što je to slučaj sa <a href="/wiki/Interferon_tip_I" title="Interferon tip I">tip I</a> interferonima.<sup id="cite_ref-KubyImmunology6th_2-0" class="reference"><a href="#cite_note-KubyImmunology6th-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Otkriće"><span id="Otkri.C4.87e"></span>Otkriće</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=1" title="Uredi odjeljak Otkriće" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=1" title="Uredi kôd odjeljka Otkriće"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-28 je otkrila <a href="/wiki/2003" title="2003">2003</a>. godine kompanija Zymogenetics<sup id="cite_ref-pmid12469119_4-0" class="reference"><a href="#cite_note-pmid12469119-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> koristeći proces genomskog skriniranja u kome je celokupan ljudski genom skeniran za pretpostavljene gene. Kad su jednom ti geni nađeni, drugi sken je izvršen da bi specifično tražili citokini. Oba IL-28 i IL-29 su nađena kod ljudi koristeći ovaj tip analize. </p> <div class="mw-heading mw-heading2"><h2 id="Struktura">Struktura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=2" title="Uredi odjeljak Struktura" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=2" title="Uredi kôd odjeljka Struktura"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-28 <a href="/wiki/Gen" title="Gen">geni</a> su locirani blizu IL-29 na <a href="/wiki/Hromozom_19" class="mw-redirect" title="Hromozom 19">hromozomu 19</a> kod ljudi. Dve IL-28 izoforme (IL-28A i IL-28B) su 96% homologne, mada razlike u funkciji između dve forme ostaju nejasne. </p><p>Receptor za IL-28 se sastoji od jedinstvenog IL-28 receptor alfa lanca, koji formira par sa IL-10 receptor beta lancom, što navodi mnoge da klasifikuju IL-28 kao člana IL-10-poput familije. </p> <div class="mw-heading mw-heading2"><h2 id="Funkcija">Funkcija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=3" title="Uredi odjeljak Funkcija" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=3" title="Uredi kôd odjeljka Funkcija"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Za IL-28 je isto bilo pokazano da igra ulogu u adaptivnom imunom odgovoru, pošto njegova upotreba kao imuno-adjuvanta u toku vakcinacije malih životinja dovodi do uvećanog antigen-specifičnog <a href="/wiki/Interferon-gama" title="Interferon-gama">interferon gama</a> oslobađanja, kao i povećanog citotoksičnog potencijala u CD8+ T ćelijama. </p> <div class="mw-heading mw-heading2"><h2 id="Klinički_značaj"><span id="Klini.C4.8Dki_zna.C4.8Daj"></span>Klinički značaj</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=4" title="Uredi odjeljak Klinički značaj" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=4" title="Uredi kôd odjeljka Klinički značaj"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Dodatak IL-28 kod vakcinacije rezultuje u 100% zaštiti od letalnog H1N1 influenca izazova u modelu na malim životinjama kad je korišćen u paru sa influenca vakcinom koja zaštićuje u samo 50% slučajeve bez IL-28.<sup id="cite_ref-pmid19304955_5-0" class="reference"><a href="#cite_note-pmid19304955-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Pojedinačni nukleotidni <a href="/wiki/Polimorfizam" class="mw-disambig" title="Polimorfizam">polimorfizam</a> (<a href="/wiki/SNP" class="mw-disambig" title="SNP">SNP</a>) blizu IL28B gena može predvideti odgovor na <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> tretman sa <a href="/wiki/Interferon" title="Interferon">interferonom</a> i <a href="/wiki/Ribavirin" title="Ribavirin">ribavirinom</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=5" title="Uredi odjeljak Reference" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=5" title="Uredi kôd odjeljka Reference"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r41556849">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-pmid15171810-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid15171810_1-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Kempuraj D, Donelan J, Frydas S, Iezzi T, Conti F, Boucher W, Papadopoulou NG, Madhappan B, Letourneau L, Cao J, Sabatino G, Meneghini F, Stellin L, Verna N, Riccioni G, Theoharides TC (2004). „Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities”. <i>Int J Immunopathol Pharmacol</i> <b>17</b> (2): 103–6. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15171810">15171810</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-28+and+29+%28IL-28+and+IL-29%29%3A+new+cytokines+with+anti-viral+activities&rft.jtitle=Int+J+Immunopathol+Pharmacol&rft.aulast=Kempuraj+D%2C+Donelan+J%2C+Frydas+S%2C+Iezzi+T%2C+Conti+F%2C+Boucher+W%2C+Papadopoulou+NG%2C+Madhappan+B%2C+Letourneau+L%2C+Cao+J%2C+Sabatino+G%2C+Meneghini+F%2C+Stellin+L%2C+Verna+N%2C+Riccioni+G%2C+Theoharides+TC&rft.au=Kempuraj+D%2C+Donelan+J%2C+Frydas+S%2C+Iezzi+T%2C+Conti+F%2C+Boucher+W%2C+Papadopoulou+NG%2C+Madhappan+B%2C+Letourneau+L%2C+Cao+J%2C+Sabatino+G%2C+Meneghini+F%2C+Stellin+L%2C+Verna+N%2C+Riccioni+G%2C+Theoharides+TC&rft.date=2004&rft.volume=17&rft.issue=2&rft.pages=103%E2%80%936&rft_id=info:pmid/15171810&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-KubyImmunology6th-2"><span class="mw-cite-backlink"><a href="#cite_ref-KubyImmunology6th_2-0">↑</a></span> <span class="reference-text"><span class="citation book">Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). <a rel="nofollow" class="external text" href="http://bcs.whfreeman.com/immunology6e/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0"><i>Kuby Immunology</i></a> (6 izd.). New York: W H Freeman and company. <a href="/wiki/International_Standard_Book_Number" class="mw-redirect" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/1-4292-0211-4" title="Posebno:Traži ISBN/1-4292-0211-4">1-4292-0211-4</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Kuby+Immunology&rft.aulast=Thomas+J.+Kindt%2C+Richard+A.+Goldsby%2C+Barbara+Anne+Osborne%2C+Janis+Kuby&rft.au=Thomas+J.+Kindt%2C+Richard+A.+Goldsby%2C+Barbara+Anne+Osborne%2C+Janis+Kuby&rft.date=2006&rft.edition=6&rft.place=New+York&rft.pub=W+H+Freeman+and+company&rft.isbn=1-4292-0211-4&rft_id=http%3A%2F%2Fbcs.whfreeman.com%2Fimmunology6e%2Fdefault.asp%3Fs%3D%26n%3D%26i%3D%26v%3D%26o%3D%26ns%3D0%26uid%3D0%26rau%3D0&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="citation book">Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/book/9780124983403"><i>Cytokines (Handbook of Immunopharmacology)</i></a>. Boston: Academic Press. <a href="/wiki/International_Standard_Book_Number" class="mw-redirect" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/0-12-498340-5" title="Posebno:Traži ISBN/0-12-498340-5">0-12-498340-5</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Cytokines+%28Handbook+of+Immunopharmacology%29&rft.date=1998&rft.place=Boston&rft.pub=Academic+Press&rft.isbn=0-12-498340-5&rft_id=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9780124983403&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid12469119-4"><span class="mw-cite-backlink"><a href="#cite_ref-pmid12469119_4-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (January 2003). „IL-28, IL-29 and their class II cytokine receptor IL-28R”. <i>Nat. Immunol.</i> <b>4</b> (1): 63–8. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fni873">10.1038/ni873</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12469119">12469119</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-28%2C+IL-29+and+their+class+II+cytokine+receptor+IL-28R&rft.jtitle=Nat.+Immunol.&rft.aulast=Sheppard+P%2C+Kindsvogel+W%2C+Xu+W%2C+Henderson+K%2C+Schlutsmeyer+S%2C+Whitmore+TE%2C+Kuestner+R%2C+Garrigues+U%2C+Birks+C%2C+Roraback+J%2C+Ostrander+C%2C+Dong+D%2C+Shin+J%2C+Presnell+S%2C+Fox+B%2C+Haldeman+B%2C+Cooper+E%2C+Taft+D%2C+Gilbert+T%2C+Grant+FJ%2C+Tackett+M%2C+Krivan+W%2C+McKnight+G%2C+Clegg+C%2C+Foster+D%2C+Klucher+KM&rft.au=Sheppard+P%2C+Kindsvogel+W%2C+Xu+W%2C+Henderson+K%2C+Schlutsmeyer+S%2C+Whitmore+TE%2C+Kuestner+R%2C+Garrigues+U%2C+Birks+C%2C+Roraback+J%2C+Ostrander+C%2C+Dong+D%2C+Shin+J%2C+Presnell+S%2C+Fox+B%2C+Haldeman+B%2C+Cooper+E%2C+Taft+D%2C+Gilbert+T%2C+Grant+FJ%2C+Tackett+M%2C+Krivan+W%2C+McKnight+G%2C+Clegg+C%2C+Foster+D%2C+Klucher+KM&rft.date=January+2003&rft.volume=4&rft.issue=1&rft.pages=63%E2%80%938&rft_id=info:doi/10.1038%2Fni873&rft_id=info:pmid/12469119&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid19304955-5"><span class="mw-cite-backlink"><a href="#cite_ref-pmid19304955_5-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Morrow MP, Pankhong P, Laddy DJ, Schoenly KA, Yan J, Cisper N, Weiner DB (June 2009). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2700323/">„Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity”</a>. <i>Blood</i> <b>113</b> (23): 5868–77. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1182%2Fblood-2008-11-190520">10.1182/blood-2008-11-190520</a>. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2700323">2700323</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/19304955">19304955</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+ability+of+IL-12+and+IL-28B+to+regulate+Treg+populations+and+enhance+adaptive+cellular+immunity&rft.jtitle=Blood&rft.aulast=Morrow+MP%2C+Pankhong+P%2C+Laddy+DJ%2C+Schoenly+KA%2C+Yan+J%2C+Cisper+N%2C+Weiner+DB&rft.au=Morrow+MP%2C+Pankhong+P%2C+Laddy+DJ%2C+Schoenly+KA%2C+Yan+J%2C+Cisper+N%2C+Weiner+DB&rft.date=June+2009&rft.volume=113&rft.issue=23&rft.pages=5868%E2%80%9377&rft_id=info:doi/10.1182%2Fblood-2008-11-190520&rft_id=info:pmc/2700323&rft_id=info:pmid/19304955&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2700323%2F&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><span class="citation web">PGxNews.Org (August 2009). <a rel="nofollow" class="external text" href="http://www.pgxnews.org/web/pgx-pharmacogenomics-articles-reviews/40-pgx-pharmacogenomics-article-review/104-new-biomarker-predicts-response-to-hepatitis-c-treatment">„New biomarker predicts response to hepatitis C treatment”</a>. PGxNews.Org<span class="reference-accessdate">. Pristupljeno 17. 8. 2009</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=New+biomarker+predicts+response+to+hepatitis+C+treatment&rft.atitle=&rft.aulast=PGxNews.Org&rft.au=PGxNews.Org&rft.date=August+2009&rft.pub=PGxNews.Org&rft_id=http%3A%2F%2Fwww.pgxnews.org%2Fweb%2Fpgx-pharmacogenomics-articles-reviews%2F40-pgx-pharmacogenomics-article-review%2F104-new-biomarker-predicts-response-to-hepatitis-c-treatment&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><span class="citation Journal">Ge D, Fellay j, Thompson A, <i>et al.</i> (2009). „Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance”. <i>Nature</i> <b>461</b> (7262): 399–401. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fnature08309">10.1038/nature08309</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/19684573">19684573</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+variation+in+IL28B+predicts+hepatitis+C+treatment-induced+viral+clearance&rft.jtitle=Nature&rft.aulast=Ge+D%2C+Fellay+j%2C+Thompson+A%2C+%27%27et+al.%27%27&rft.au=Ge+D%2C+Fellay+j%2C+Thompson+A%2C+%27%27et+al.%27%27&rft.date=2009&rft.volume=461&rft.issue=7262&rft.pages=399%E2%80%93401&rft_id=info:doi/10.1038%2Fnature08309&rft_id=info:pmid/19684573&rfr_id=info:sid/en.wikipedia.org:Interleukin_28"><span style="display: none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_28&veaction=edit&section=6" title="Uredi odjeljak Spoljašnje veze" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_28&action=edit&section=6" title="Uredi kôd odjeljka Spoljašnje veze"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">MeSH</a> <i><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Interleukin-28">Interleukin-28</a></i></li></ul> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/Cytokines" title="Cytokines"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <a href="https://commons.wikimedia.org/wiki/Main_page" class="extiw" title="commons:Main page">Wikimedia Commons</a> ima još multimedijalnih datoteka vezanih za: <b><i><a href="https://commons.wikimedia.org/wiki/Category:Cytokines" class="extiw" title="commons:Category:Cytokines">Interleukin 28</a></i></b></li></ul> <div style="clear:both;"></div> <div class="navbox-styles nomobile"><style data-mw-deduplicate="TemplateStyles:r41348688">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid 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title="Interleukin 5">IL-5</a> •  <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">IL-7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">IL-8</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">IL-9</a> •  <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a> •  <a href="/wiki/Interleukin_11" title="Interleukin 11">IL-11</a> •  <a href="/wiki/Interleukin_12" title="Interleukin 12">IL-12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">IL-14</a> •  <a href="/wiki/Interleukin_15" title="Interleukin 15">IL-15</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">IL-16</a> •  <a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">IL-18</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">IL-19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">IL-20</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">IL-21</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a> •  <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">IL-24</a> •  <a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">IL-26</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">IL-27</a> •  <a class="mw-selflink selflink">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">IL-30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">IL-31</a> •  <a href="/wiki/Interleukin_32" title="Interleukin 32">IL-32</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">IL-33</a> •  <a href="/wiki/Interleukin_34" title="Interleukin 34">IL-34</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">IL-35</a></div></td></tr></tbody></table></div> <div class="navbox-styles nomobile"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41348688"></div><div role="navigation" class="navbox" aria-labelledby="Ćelijska_komunikacija:_Citokini" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41556979"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41556873"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-prikaži"><a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat"><abbr title="Pogledajte šablon" 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class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po familiji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-1" class="mw-disambig" title="IL-1">IL-1</a> superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_1" title="Interleukin 1">1</a> (<a href="/wiki/Antagonist_interleukin-1_receptora" title="Antagonist interleukin-1 receptora">1Ra</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">18</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">33</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">poput <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>/<a href="/wiki/Glikoprotein_130" title="Glikoprotein 130">gp130</a> koristeći</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_6" title="Interleukin 6">6</a>  •  <a href="/wiki/Interleukin_11" title="Interleukin 11">11</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">31</a> (+ne IL <a href="/wiki/Onkostatin_M" title="Onkostatin M">Onkostatin M</a>, <a href="/wiki/Inhibitorni_faktor_leukemije" title="Inhibitorni faktor leukemije">Inhibitorni faktor leukemije</a>, <a href="/wiki/Cilijarni_neurotrofni_faktor" title="Cilijarni neurotrofni faktor">Cilijarni neurotrofni faktor</a>, <a href="/wiki/Kardiotrofin_1" title="Kardiotrofin 1">Kardiotrofin 1</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-10" class="mw-disambig" title="IL-10">IL-10</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_10" title="Interleukin 10">10</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">20</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">22</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">24</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">26</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">Interferon tip III</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a class="mw-selflink selflink">28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">29</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Zajedni%C4%8Dki_gama_lanac" class="mw-redirect" title="Zajednički gama lanac">Zajednički γ-lanac</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_2" title="Interleukin 2">2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">15</a> •  <a href="/wiki/Interleukin_3" title="Interleukin 3">3</a> •  <a href="/wiki/Interleukin_4" title="Interleukin 4">4</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">7</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">9</a> •  <a href="/wiki/Interleukin_13" title="Interleukin 13">13</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">21</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-12" class="mw-disambig" title="IL-12">IL-12</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_12" title="Interleukin 12">12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_23" title="Interleukin 23">23</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">35</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Drugi</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_5" title="Interleukin 5">5</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">14</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">16</a> •  <a href="/wiki/Interleukin_17" title="Interleukin 17">17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">25</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_32" title="Interleukin 32">32</a>  •  <a href="/wiki/Interleukin_34" title="Interleukin 34">34</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Hemokini" class="mw-redirect" title="Hemokini">Hemokini</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CCL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CCL1" title="CCL1">1</a> •  <a href="/wiki/CCL2" title="CCL2">2</a> •  <a href="/wiki/Makrofagni_inflamatorni_protein" title="Makrofagni inflamatorni protein">3</a> •  <a href="/wiki/CCL4" title="CCL4">4</a> •  <a href="/wiki/CCL5" title="CCL5">5</a> •  <a href="/wiki/CCL6" title="CCL6">6</a> •  <a href="/wiki/CCL7" title="CCL7">7</a> •  <a href="/wiki/CCL8" title="CCL8">8</a> •  <a href="/wiki/CCL9" title="CCL9">9</a> •  <a href="/wiki/CCL9" title="CCL9">10</a> •  <a href="/wiki/CCL11" title="CCL11">11</a> •  <a href="/wiki/CCL12" title="CCL12">12</a> •  <a href="/wiki/CCL13" title="CCL13">13</a> •  <a href="/wiki/CCL14" title="CCL14">14</a> •  <a href="/wiki/CCL15" title="CCL15">15</a> •  <a href="/wiki/CCL16" title="CCL16">16</a> •  <a href="/wiki/CCL17" title="CCL17">17</a> •  <a href="/wiki/CCL18" title="CCL18">18</a> •  <a href="/wiki/CCL19" title="CCL19">19</a> •  <a href="/wiki/CCL20" title="CCL20">20</a> •  <a href="/wiki/CCL21" title="CCL21">21</a> •  <a href="/wiki/CCL22" title="CCL22">22</a> •  <a href="/wiki/CCL23" title="CCL23">23</a> •  <a href="/wiki/CCL24" title="CCL24">24</a> •  <a href="/wiki/CCL25" title="CCL25">25</a> •  <a href="/wiki/CCL26" title="CCL26">26</a> •  <a href="/wiki/CCL27" title="CCL27">27</a> •  <a href="/wiki/CCL28" title="CCL28">28</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CXCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CXCL1" title="CXCL1">1</a> •  <a href="/wiki/CXCL2" title="CXCL2">2</a> •  <a href="/wiki/CXCL3" title="CXCL3">3</a> •  <a href="/wiki/Trombocit_faktor_4" title="Trombocit faktor 4">4</a> •  <a href="/wiki/CXCL5" title="CXCL5">5</a> •  <a href="/wiki/CXCL6" title="CXCL6">6</a> •  <a href="/wiki/CXCL7" title="CXCL7">7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/CXCL9" title="CXCL9">9</a> •  <a href="/wiki/CXCL10" title="CXCL10">10</a> •  <a href="/wiki/CXCL11" title="CXCL11">11</a> •  <a href="/wiki/CXCL12" title="CXCL12">12</a> •  <a href="/wiki/CXCL13" title="CXCL13">13</a> •  <a href="/wiki/CXCL14" title="CXCL14">14</a> •  <a href="/wiki/CXCL15" title="CXCL15">15</a> •  <a href="/wiki/CXCL16" title="CXCL16">16</a> •  <a href="/wiki/CXCL17" title="CXCL17">17</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CX3CL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CX3CL1" title="CX3CL1">1</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">XCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/XCL1" title="XCL1">1</a> •  <a href="/wiki/XCL2" title="XCL2">2</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Faktori_nekroze_tumora" title="Faktori nekroze tumora">TNF</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Glavni</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">TNF (<a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">ligand</a>) superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/4-1BB_ligand" title="4-1BB ligand">4-1BB ligand</a> •  <a href="/wiki/Faktor_aktivacije_B-%C4%87elija" title="Faktor aktivacije B-ćelija">Faktor aktivacije B-ćelija</a> •  <a href="/wiki/Fas_ligand" title="Fas ligand">FAS ligand</a> •  <a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a> •  <a href="/wiki/OX40L" title="OX40L">OX40L</a> •  <a href="/wiki/RANKL" title="RANKL">RANKL</a> •  <a href="/wiki/TRAIL" title="TRAIL">TRAIL</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Klaster_diferencijacije" title="Klaster diferencijacije">Klaster diferencijacije</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CD70" title="CD70">CD70</a> •  <a href="/wiki/CD153" title="CD153">CD153</a> •  <a href="/wiki/CD154" title="CD154">CD154</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon" title="Interferon">Interferon</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_I" title="Interferon tip I">I</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">alfa ( <a href="/wiki/Pegilirani_interferon_alfa-2a" title="Pegilirani interferon alfa-2a">Pegilirani 2a</a>, <a href="/wiki/Pegilirani_interferon_alfa-2b" title="Pegilirani interferon alfa-2b">Pegilirani 2b</a>), beta (<a href="/wiki/Interferon_beta-1a" title="Interferon beta-1a">1a</a>, <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">1b</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_II" title="Interferon tip II">II</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interferon-gama" title="Interferon-gama">Gama</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">III</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a class="mw-selflink selflink">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Drugi</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Monokin" title="Monokin">Monokin</a> •  <a href="/wiki/Limfokin" title="Limfokin">Limfokin</a> (<a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a>, <a href="/wiki/Faktor_transfera" title="Faktor transfera">Faktor transfera</a>) •  <a href="/wiki/Faktor_rasta" title="Faktor rasta">Faktor rasta</a> •  <a href="/wiki/Hematopoeza" title="Hematopoeza">Hematopoeza</a> (<a href="/wiki/Faktor_stem_%C4%87elija" title="Faktor stem ćelija">Faktor stem ćelija</a>, <a href="/wiki/Faktor_stimulacije_kolonije" title="Faktor stimulacije kolonije">Faktor stimulacije kolonije</a>) •  <a href="/wiki/GPI_(gen)" title="GPI (gen)">Faktor autokrinog motiliteta</a> •  <a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po funkciji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i><a href="/wiki/Proinflamatorni_citokin" title="Proinflamatorni citokin">proinflamatorni citokin</a></i> (<a href="/wiki/Interleukin_1" title="Interleukin 1">IL-1</a>, <a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>1</i></a> (<a href="/wiki/Interferon-gama" title="Interferon-gama">INF-gama</a> i <a href="/wiki/Faktor_nekroze_tumora-beta" class="mw-redirect" title="Faktor nekroze tumora-beta">TNF-beta</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>2</i></a> (<a href="/wiki/Interleukin_4" title="Interleukin 4">IL-4</a>, <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a>, <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>) •  <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije"><i>T<sub>h</sub>17</i></a> (<a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17</a>,<a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a>)</div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i><a href="/wiki/%C5%A0ablon:Biohemija_metanavs-lat" title="Šablon:Biohemija metanavs-lat">B</a> <a href="/wiki/%C5%A0ablon:Prenos_signala-lat" title="Šablon:Prenos signala-lat">trdu</a>: <a href="/w/index.php?title=%C5%A0ablon:Intercelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intercelularni signalni peptidi i proteini-lat (stranica ne postoji)">peptidi</a> (<a href="/wiki/%C5%A0ablon:Neuropeptidi-lat" title="Šablon:Neuropeptidi-lat">nrpl</a>/<a href="/wiki/%C5%A0ablon:Faktori_rasta-lat" title="Šablon:Faktori rasta-lat">grfl</a>/<a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat">cytl</a>/<a href="/wiki/%C5%A0ablon:Hormoni-lat" title="Šablon:Hormoni-lat">horl</a>), <a href="/w/index.php?title=%C5%A0ablon:Receptori_%C4%87elijske_povr%C5%A1ine-lat&action=edit&redlink=1" class="new" title="Šablon:Receptori ćelijske površine-lat (stranica ne postoji)">receptori</a> (<a href="/w/index.php?title=%C5%A0ablon:Ligand-kontrolisani_jonski_kanali-lat&action=edit&redlink=1" class="new" title="Šablon:Ligand-kontrolisani jonski kanali-lat (stranica ne postoji)">lgic</a>, <a href="/w/index.php?title=%C5%A0ablon:Enzim-vezani_receptori-lat&action=edit&redlink=1" class="new" title="Šablon:Enzim-vezani receptori-lat (stranica ne postoji)">enzr</a>, <a href="/wiki/%C5%A0ablon:G_protein_spregnuti_receptori-lat" title="Šablon:G protein spregnuti receptori-lat">gprc</a>, <a href="/wiki/%C5%A0ablon:Imunoglobulinska_superfamilija_imunskih_receptora-lat" title="Šablon:Imunoglobulinska superfamilija imunskih receptora-lat">igsr</a>, <a href="/w/index.php?title=%C5%A0ablon:Integrini-lat&action=edit&redlink=1" class="new" title="Šablon:Integrini-lat (stranica ne postoji)">intg</a>, <a href="/wiki/%C5%A0ablon:Neuropeptidni_receptori-lat" title="Šablon:Neuropeptidni receptori-lat">nrpr</a>/<a href="/wiki/%C5%A0ablon:Receptori_faktora_rasta-lat" title="Šablon:Receptori faktora rasta-lat">grfr</a>/<a href="/wiki/%C5%A0ablon:Citokinski_receptori-lat" class="mw-redirect" title="Šablon:Citokinski receptori-lat">cytr</a>), <a href="/w/index.php?title=%C5%A0ablon:Intracelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intracelularni signalni peptidi i proteini-lat (stranica ne postoji)">itra</a> (<a href="/w/index.php?title=%C5%A0ablon:Adapterski_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Adapterski proteini-lat (stranica ne postoji)">adap</a>, <a href="/wiki/%C5%A0ablon:Regulatori_GTP-vezuju%C4%87ih_proteina-lat" title="Šablon:Regulatori GTP-vezujućih proteina-lat">gbpr</a>, <a href="/w/index.php?title=%C5%A0ablon:Aktivacija_MAP_kinaze-lat&action=edit&redlink=1" class="new" title="Šablon:Aktivacija MAP kinaze-lat (stranica ne postoji)">mapk</a>), <a href="/w/index.php?title=%C5%A0ablon:Kalcjiumska_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:Kalcjiumska signalizacija-lat (stranica ne postoji)">calc</a>, <a href="/wiki/%C5%A0ablon:Lipidna_signalizacija-lat" title="Šablon:Lipidna signalizacija-lat">lipd</a>, signalni putevi (<a href="/w/index.php?title=%C5%A0ablon:Hedgehog_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hedgehog signalni put-lat (stranica ne postoji)">hedp</a>, <a href="/w/index.php?title=%C5%A0ablon:Wnt_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Wnt signalni put-lat (stranica ne postoji)">wntp</a>, <a href="/w/index.php?title=%C5%A0ablon:TGF_beta_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:TGF beta signalizacija-lat (stranica ne postoji)">tgfp</a>+<a href="/wiki/%C5%A0ablon:MAPK_ERK_signalni_put-lat" title="Šablon:MAPK ERK signalni put-lat">mapp</a>, <a href="/w/index.php?title=%C5%A0ablon:Notch_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Notch signalni put-lat (stranica ne postoji)">notp</a>, <a href="/w/index.php?title=%C5%A0ablon:JAK-STAT_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:JAK-STAT signalni put-lat (stranica ne postoji)">jakp</a>, <a href="/wiki/%C5%A0ablon:Apoptozni_signalni_put-lat" title="Šablon:Apoptozni signalni put-lat">fsap</a>, <a href="/w/index.php?title=%C5%A0ablon:Hippo_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hippo signalni put-lat (stranica ne postoji)">hipp</a>, <a href="/w/index.php?title=%C5%A0ablon:TLR_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:TLR signalni put-lat (stranica ne postoji)">tlrp</a>)</i></div></td></tr></tbody></table></div>    </div><noscript><img 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