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The Science of Cyanide - SCIENCE UNFILTERED

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<div class="mega-container"> <div id="content" class="site-content container"> <div id="primary-mono" class="content-area col-md-8"> <main id="main" class="site-main" role="main"> <article id="post-7554" class="post-7554 post type-post status-publish format-standard has-post-thumbnail hentry category-featured category-science-news category-pharma-biopharma-industry-articles tag-adenosine-triphosphate tag-cyanide tag-poison tag-spy"> <div id="featured-image"> <img width="810" height="450" src="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?fit=810%2C450&amp;ssl=1" class="attachment-full size-full wp-post-image" alt="cyanide" decoding="async" srcset="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?w=810&amp;ssl=1 810w, https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?resize=300%2C167&amp;ssl=1 300w, https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?resize=768%2C427&amp;ssl=1 768w" sizes="(max-width: 810px) 100vw, 810px" data-attachment-id="7559" data-permalink="https://phenomenex.blog/2017/09/22/cyanide-science/cyanide-post/" data-orig-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?fit=810%2C450&amp;ssl=1" data-orig-size="810,450" data-comments-opened="1" data-image-meta="{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}" data-image-title="cyanide post" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?fit=300%2C167&amp;ssl=1" data-large-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide-post.png?fit=810%2C450&amp;ssl=1" /> </div> <header class="entry-header"> <h1 class="entry-title title-font">The Science of Cyanide</h1> <div class="entry-meta"> <span class="posted-on">Posted on <a href="https://phenomenex.blog/2017/09/22/cyanide-science/" rel="bookmark"><time class="entry-date published" datetime="2017-09-22T17:06:40-07:00">September 22, 2017</time><time class="updated" datetime="2017-09-22T17:06:41-07:00">September 22, 2017</time></a></span><span class="byline"> by <span class="author vcard"><a class="url fn n" href="https://phenomenex.blog/author/phenomenex/">Science Unfiltered</a></span></span> </div><!-- .entry-meta --> </header><!-- .entry-header --> <div class="entry-content"> <div class="dkpdf-button-container" style=" text-align:right "> <a class="dkpdf-button" href="/2017/09/22/cyanide-science/?pdf=7554" target="_blank"><span class="dkpdf-button-icon"><i class="fa fa-file-pdf-o"></i></span> Download PDF</a> </div> <h2>Ever find yourself watching a WWII spy movie, and an enemy spy is captured?</h2> <p>Those scenes usually play out the same, with the good guys yelling questions at the enemy with hopes for answers, only for the bad guy to flash one last mischievous smile, crunch down on a capsule hidden in their mouth, and die a few seconds later.</p> <p>Have you ever wondered, “what is in that pill and why does it work so fast?”</p> <p>Those little lethal pills are filled with a chemical called cyanide.</p> <p>The term “cyanide” refers to any chemical containing a carbon-nitrogen (CN) bond. What is interesting is that many substances contain cyanide, but not all of them are deadly. Sodium cyanide<a href="https://phenomenex.blog/2017/09/22/cyanide-science/cyanide3/" rel="attachment wp-att-7557"><img data-recalc-dims="1" decoding="async" data-attachment-id="7557" data-permalink="https://phenomenex.blog/2017/09/22/cyanide-science/cyanide3/" data-orig-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?fit=264%2C599&amp;ssl=1" data-orig-size="264,599" data-comments-opened="1" data-image-meta="{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}" data-image-title="cyanide3" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?fit=132%2C300&amp;ssl=1" data-large-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?fit=264%2C599&amp;ssl=1" class="alignright wp-image-7557 size-medium" src="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?resize=132%2C300&#038;ssl=1" alt="cyanide" width="132" height="300" srcset="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?resize=132%2C300&amp;ssl=1 132w, https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/cyanide3.png?w=264&amp;ssl=1 264w" sizes="(max-width: 132px) 100vw, 132px" /></a> (NaCN), potassium cyanide (KCN), hydrogen cyanide (HCN), and cyanogen chloride (CNCI) are lethal, but thousands of compounds called nitriles contain the cyanide group, but aren’t as toxic. Nitriles aren’t as dangerous, and can actually be found in some pharmaceuticals, because they don’t release the CN ion.</p> <p><span style="color: #000000;"><strong>But How Does Cyanide Work?</strong></span></p> <p>The cyanide ion, CN, binds to the iron atom in cytochrome C oxidase in the mitochondria of the cells and acts as an irreversible enzyme inhibitor. This prevents cytochrome C oxidase from doing what it needs to do, which is to send electrons to oxygen in the electron transport chain of aerobic cellular respiration.</p> <p>Mitochondria are then unable to produce the energy carrier adenosine triphosphate (ATP), without oxygen. This results in tissues that require this form of energy, like heart muscle cells and nerve cells, quickly expand all their energy and being to die. When these die…the victim dies.</p> <p>In more layman’s terms, cyanide works by interfering with the subtle chemical mechanism in our cells. It essentially prevents cells from using oxygen to make energy molecules. Our cells need energy, and that energy comes from sugars in our food. This process is call respiration, which is the chemical reaction of our cells using oxygen molecules from the air we breathe to free up energy from sugar.</p> <p>So, when cyanide molecules are introduced in the system, it throws off the cell’s mechanism of respiration. The cyanide molecules look like oxygen to the parts of the cell responsible for respiration (the mitochondria), confusing our cells into latching onto the poison in hopes of energy.</p> <p><span style="color: #000000;"><strong>Why is Cyanide Poisoning So Terrible?</strong></span></p> <p>If poisoned with this deadly chemical, the individual’s diaphragm will begin to slow down in contractions, leaving the victim gasping for air. Skeletal muscles in the face, arms, and body will also begin to seize up, making the person convolute and contract. Finally, the heart will beat less and less until it stops completely, resulting in cardiac arrest.</p> <p>One reason cyanide gains such a bad repour is that the victim is entirely conscious for the whole ordeal. They can feel every muscle in their body start to tense, and all they can do is wait for the few minutes to be over. Eventually the victim will pass out and when their brain shuts down from lack of oxygen, it is all finally over.</p> <p>The process can be quick; however, it depends on the amount of poison administered. If given a lethal amount, it can last from 2-5 minutes.</p> <p>Cyanide is able to kill so fast because the molecules are exceptionally small and can dispense throughout the entire body very quickly, affecting all major organs and tissues in a short amount of time.</p> <p>It may not be an honorable way to go, but the effectiveness and the relatively quick process (depending on the amount of cyanide administered), made an effective way to prevent captured spies giving up secrets to the enemy.</p> <p><a href="https://phenomenex.blog/2017/09/22/cyanide-science/spy/" rel="attachment wp-att-7558"><img data-recalc-dims="1" decoding="async" data-attachment-id="7558" data-permalink="https://phenomenex.blog/2017/09/22/cyanide-science/spy/" data-orig-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?fit=720%2C720&amp;ssl=1" data-orig-size="720,720" data-comments-opened="1" data-image-meta="{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}" data-image-title="spy" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?fit=300%2C300&amp;ssl=1" data-large-file="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?fit=720%2C720&amp;ssl=1" class="aligncenter wp-image-7558 size-medium" src="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?resize=300%2C300&#038;ssl=1" alt="cyanide" width="300" height="300" srcset="https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?resize=300%2C300&amp;ssl=1 300w, https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?resize=150%2C150&amp;ssl=1 150w, https://i0.wp.com/phenomenex.blog/wp-content/uploads/2017/09/spy.jpg?w=720&amp;ssl=1 720w" sizes="(max-width: 300px) 100vw, 300px" /></a></p> <div class="sharedaddy sd-sharing-enabled"><div class="robots-nocontent sd-block sd-social sd-social-icon sd-sharing"><h3 class="sd-title">Share with friends and coworkers:</h3><div class="sd-content"><ul><li class="share-linkedin"><a rel="nofollow noopener noreferrer" data-shared="sharing-linkedin-7554" class="share-linkedin sd-button share-icon no-text" href="https://phenomenex.blog/2017/09/22/cyanide-science/?share=linkedin" target="_blank" title="Click to share on LinkedIn" ><span></span><span class="sharing-screen-reader-text">Click to share on LinkedIn (Opens in new window)</span></a></li><li class="share-facebook"><a rel="nofollow noopener noreferrer" data-shared="sharing-facebook-7554" class="share-facebook sd-button share-icon no-text" href="https://phenomenex.blog/2017/09/22/cyanide-science/?share=facebook" target="_blank" title="Click to share on Facebook" ><span></span><span class="sharing-screen-reader-text">Click to share on Facebook (Opens in new window)</span></a></li><li class="share-twitter"><a rel="nofollow noopener noreferrer" data-shared="sharing-twitter-7554" class="share-twitter sd-button share-icon no-text" href="https://phenomenex.blog/2017/09/22/cyanide-science/?share=twitter" target="_blank" title="Click to share on Twitter" ><span></span><span class="sharing-screen-reader-text">Click to share on Twitter (Opens in new window)</span></a></li><li class="share-jetpack-whatsapp"><a rel="nofollow noopener noreferrer" data-shared="" class="share-jetpack-whatsapp sd-button share-icon no-text" href="https://phenomenex.blog/2017/09/22/cyanide-science/?share=jetpack-whatsapp" target="_blank" title="Click to share on WhatsApp" ><span></span><span class="sharing-screen-reader-text">Click to share on WhatsApp (Opens in new window)</span></a></li><li class="share-email"><a rel="nofollow noopener noreferrer" data-shared="" class="share-email sd-button share-icon no-text" href="mailto:?subject=%5BShared%20Post%5D%20The%20Science%20of%20Cyanide&body=https%3A%2F%2Fphenomenex.blog%2F2017%2F09%2F22%2Fcyanide-science%2F&share=email" target="_blank" title="Click to email a link to a friend" data-email-share-error-title="Do you have email set up?" data-email-share-error-text="If you&#039;re having problems sharing via email, you might not have email set up for your browser. 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But have you ever stopped to wonder what causes it to be lethal? </span></div><div class="snippet-clear"></div><meta itemscope itemprop="mainEntityOfPage" itemType="https://schema.org/WebPage" itemid="https://phenomenex.blog/2017/09/22/cyanide-science/"/><meta itemprop="datePublished" content="2017-09-22T17:06:40-07:00"/><meta itemprop="dateModified" content="2017-09-22T17:06:41-07:00"/></div> </div></div><div class="snippet-clear"></div> </div><!-- .entry-content --> <footer class="entry-footer"> <span class="cat-links">Posted in <a href="https://phenomenex.blog/category/featured/" rel="category tag">Featured</a>, <a href="https://phenomenex.blog/category/science-news/" rel="category tag">Fun Science</a>, <a href="https://phenomenex.blog/category/pharma-biopharma-industry-articles/" rel="category tag">Pharma / Biopharma</a></span><span class="tags-links">Tagged <a href="https://phenomenex.blog/tag/adenosine-triphosphate/" rel="tag">adenosine triphosphate</a>, <a href="https://phenomenex.blog/tag/cyanide/" rel="tag">cyanide</a>, <a href="https://phenomenex.blog/tag/poison/" rel="tag">poison</a>, <a href="https://phenomenex.blog/tag/spy/" rel="tag">spy</a></span> </footer><!-- .entry-footer --> </article><!-- #post-## --> <div id="comments" class="comments-area"> <div id="respond" class="comment-respond"> <h3 id="reply-title" class="comment-reply-title">Leave a Reply<small><a rel="nofollow" id="cancel-comment-reply-link" href="/2017/09/22/cyanide-science/#respond" style="display:none;">Cancel reply</a></small></h3> <form id="commentform" class="comment-form"> <iframe title="Comment Form" src="https://jetpack.wordpress.com/jetpack-comment/?blogid=89572901&#038;postid=7554&#038;comment_registration=0&#038;require_name_email=1&#038;stc_enabled=1&#038;stb_enabled=1&#038;show_avatars=1&#038;avatar_default=identicon&#038;greeting=Leave+a+Reply&#038;jetpack_comments_nonce=fb2db15b32&#038;greeting_reply=Leave+a+Reply+to+%25s&#038;color_scheme=light&#038;lang=en_US&#038;jetpack_version=14.1-a.7&#038;iframe_unique_id=1&#038;show_cookie_consent=0&#038;has_cookie_consent=0&#038;is_current_user_subscribed=0&#038;token_key=%3Bnormal%3B&#038;sig=d5b4e3e48f484588b2eb7a6304828f2e899bbbbd#parent=https%3A%2F%2Fphenomenex.blog%2F2017%2F09%2F22%2Fcyanide-science%2F" name="jetpack_remote_comment" style="width:100%; height: 430px; border:0;" class="jetpack_remote_comment" id="jetpack_remote_comment" sandbox="allow-same-origin allow-top-navigation allow-scripts allow-forms allow-popups" > </iframe> <!--[if !IE]><!--> <script> document.addEventListener('DOMContentLoaded', function () { var commentForms = document.getElementsByClassName('jetpack_remote_comment'); for (var i = 0; i < commentForms.length; i++) { commentForms[i].allowTransparency = false; commentForms[i].scrolling = 'no'; } }); </script> <!--<![endif]--> </form> </div> <input type="hidden" name="comment_parent" id="comment_parent" value="" /> <p class="akismet_comment_form_privacy_notice">This site uses Akismet to reduce spam. <a href="https://akismet.com/privacy/" target="_blank" rel="nofollow noopener">Learn how your comment data is processed</a>.</p> </div><!-- #comments --> </main><!-- #main --> </div><!-- #primary --> <div id="secondary" class="widget-area col-md-4" role="complementary"> <aside id="blog_subscription-3" class="widget widget_blog_subscription jetpack_subscription_widget"><h3 class="widget-title title-font">Subscribe!</h3> <div class="wp-block-jetpack-subscriptions__container"> <form action="#" method="post" accept-charset="utf-8" id="subscribe-blog-blog_subscription-3" data-blog="89572901" data-post_access_level="everybody" > <div id="subscribe-text"><p>Never miss another post! 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