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</a> <ul id="toc-Protein-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Medical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Medical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Medical significance</span> </div> </a> <button aria-controls="toc-Medical_significance-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Medical significance subsection</span> </button> <ul id="toc-Medical_significance-sublist" class="vector-toc-list"> <li id="toc-Inherited_mutations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Inherited_mutations"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Inherited mutations</span> </div> </a> <ul id="toc-Inherited_mutations-sublist" class="vector-toc-list"> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1.1</span> <span>Treatment</span> </div> </a> <ul id="toc-Treatment-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Acquired_mutations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Acquired_mutations"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Acquired mutations</span> </div> </a> <ul id="toc-Acquired_mutations-sublist" class="vector-toc-list"> <li id="toc-Hematological_malignancies" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Hematological_malignancies"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2.1</span> <span>Hematological malignancies</span> </div> </a> <ul id="toc-Hematological_malignancies-sublist" class="vector-toc-list"> <li id="toc-Treatment_2" class="vector-toc-list-item vector-toc-level-4"> <a class="vector-toc-link" href="#Treatment_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2.1.1</span> <span>Treatment</span> </div> </a> <ul id="toc-Treatment_2-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Solid_Tumors" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Solid_Tumors"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Solid Tumors</span> </div> </a> <ul id="toc-Solid_Tumors-sublist" class="vector-toc-list"> <li id="toc-Treatment_3" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Treatment_3"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3.1</span> <span>Treatment</span> </div> </a> <ul id="toc-Treatment_3-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item 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class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ETV6</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_ETV6_PDB_1ji7.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ETV6_PDB_1ji7.png/250px-Protein_ETV6_PDB_1ji7.png" decoding="async" width="250" height="143" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ETV6_PDB_1ji7.png/375px-Protein_ETV6_PDB_1ji7.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ETV6_PDB_1ji7.png/500px-Protein_ETV6_PDB_1ji7.png 2x" data-file-width="1045" data-file-height="597" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P97360%20or%20P41212">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P97360,P41212">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JI7">1JI7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LKY">1LKY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2DAO">2DAO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2QAR">2QAR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2QB0">2QB0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2QB1">2QB1</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/3495">ETV6</a></span>, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600618">600618</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:109336">109336</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=37560">37560</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ETV6">ETV6</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000139083">ETV6 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_12.svg" class="mw-file-description" title="Chromosome 12 (human)"><img alt="Chromosome 12 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/450px-Ideogram_human_chromosome_12.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/600px-Ideogram_human_chromosome_12.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_12_(human)" class="mw-redirect" title="Chromosome 12 (human)">Chromosome 12 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_12_ideogram.svg" class="mw-file-description" title="Chromosome 12 (human)"><img alt="Chromosome 12 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/300px-Human_chromosome_12_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/450px-Human_chromosome_12_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/600px-Human_chromosome_12_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 20.581486168579px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ETV6"><img alt="Genomic location for ETV6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 26.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ETV6"><img alt="Genomic location for ETV6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">12p13.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">11,649,674 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">11,895,377 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (mouse)"><img alt="Chromosome 6 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/260px-Ideogram_house_mouse_chromosome_6.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/390px-Ideogram_house_mouse_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/520px-Ideogram_house_mouse_chromosome_6.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 6 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (mouse)"><img alt="Chromosome 6 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/300px-Ideogram_of_house_mouse_chromosome_6.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/450px-Ideogram_of_house_mouse_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/600px-Ideogram_of_house_mouse_chromosome_6.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 258.0764551709px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ETV6"><img alt="Genomic location for ETV6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 264.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ETV6"><img alt="Genomic location for ETV6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">6 G1|6 64.58 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">134,012,663 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">134,247,121 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000139083">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">mucosa of paranasal sinus</li><br /><li style="line-height: 137%;">parotid gland</li><br /><li style="line-height: 137%;">lactiferous duct</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li><br /><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">saphenous vein</li><br /><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">tibial arteries</li><br /><li style="line-height: 137%;">minor salivary glands</li><br /><li style="line-height: 137%;">tonsil</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000030199">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">lacrimal gland</li><br /><li style="line-height: 137%;">cumulus cell</li><br /><li style="line-height: 137%;">vestibular membrane of cochlear duct</li><br /><li style="line-height: 137%;">internal carotid artery</li><br /><li style="line-height: 137%;">external carotid artery</li><br /><li style="line-height: 137%;">conjunctival fornix</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">submandibular gland</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000139083">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ETV6_205585_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/PBB_GE_ETV6_205585_at_fs.png/250px-PBB_GE_ETV6_205585_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/PBB_GE_ETV6_205585_at_fs.png/375px-PBB_GE_ETV6_205585_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/98/PBB_GE_ETV6_205585_at_fs.png/500px-PBB_GE_ETV6_205585_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2120/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001228">DNA-binding transcription activator activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000977">RNA polymerase II transcription regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001227">DNA-binding transcription repressor activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019904">protein domain specific binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071425">hematopoietic stem cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006366">transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007296">vitellogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097152">mesenchymal cell apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0022008">neurogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006357">regulation of transcription by RNA polymerase II</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2120&rn=1">2120</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=14011&rn=1">14011</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000139083;db=core">ENSG00000139083</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030199;db=core">ENSMUSG00000030199</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P41212">P41212</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P97360">P97360</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001987">NM_001987</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007961">NM_007961</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001303102">NM_001303102</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001978">NP_001978</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001290031">NP_001290031</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031987">NP_031987</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr12:11649674-11895377">Chr 12: 11.65 – 11.9 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr6:134012663-134247121">Chr 6: 134.01 – 134.25 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14914527" class="extiw" title="d:Q14914527">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14914528" class="extiw" title="d:Q14914528">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>ETV6</b> (i.e. translocation-Ets-leukemia virus) protein is a <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> that in humans is encoded by the <i>ETV6</i> (previously known as <i>TEL</i>) <a href="/wiki/Gene" title="Gene">gene</a>. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of <a href="/wiki/Hematological" class="mw-redirect" title="Hematological">hematological</a> tissues. However, its gene, <i>ETV6</i> frequently suffers various mutations that lead to an array of potentially lethal cancers, i.e., <i>ETV6</i> is a clinically significant <a href="/wiki/Oncogene" title="Oncogene">proto-oncogene</a> in that it can fuse with other genes to drive the development and/or progression of certain cancers. However, <i>ETV6</i> is also an anti-oncogene or <a href="/wiki/Tumor_suppressor_gene" title="Tumor suppressor gene">tumor suppressor gene</a> in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=1" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The human <i>ETV6</i> gene is located at position "13.2" on the short (i.e. "p") arm of chromosome 12, i.e. its notated position is 12p13.2. The gene has 8 <a href="/wiki/Exons" class="mw-redirect" title="Exons">exons</a> and two <a href="/wiki/Start_codon" title="Start codon">start codons</a>, one located at exon 1 at the start of the gene and an alternative located upstream of exon 3. <i>ETV6</i> codes for a full length protein consisting of 452 amino acids; the gene is expressed in virtually all cell types and tissues.<sup id="cite_ref-pmid22578774_5-0" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Mice depleted of the <i>ETV6</i> gene by <a href="/wiki/Gene_knockout" title="Gene knockout">Gene knockout</a> die between day 10.5 and 11.5 of embryonic life with defective <a href="/wiki/Yolk_sac" title="Yolk sac">yolk sac</a> <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a> and extensive losses in <a href="/wiki/Mesenchymal" class="mw-redirect" title="Mesenchymal">mesenchymal</a> and <a href="/wiki/Neural" class="mw-redirect" title="Neural">neural</a> cells due to <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>. Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of <a href="/wiki/Bone_marrow" title="Bone marrow">bone marrow</a>-based <a href="/wiki/Hematopoiesis" class="mw-redirect" title="Hematopoiesis">blood cell formation</a> and the vascular network.<sup id="cite_ref-pmid22578774_5-1" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28416505_7-0" class="reference"><a href="#cite_note-pmid28416505-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Protein">Protein</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=2" title="Edit section: Protein"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The human ETV6 protein is a member of the <a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS transcription factor family</a>; however, it more often acts to inhibit than stimulate transcription of its target genes. ETV6 protein contains 3 <a href="/wiki/Protein_domain" title="Protein domain">domains</a>: <b>a)</b> the pointed N-terminal (i.e. PNT) domain which forms <a href="/wiki/Oligomer" title="Oligomer">oligomer</a> partners with itself as well as other transcription factors (e.g. <a href="/wiki/FLI1" title="FLI1">FLI1</a>) and is required for ETV6's transcriptional repressing activity; <b>b)</b> the central regulatory domain; and <b>c)</b> the C-terminal <a href="/wiki/DNA-binding_domain" title="DNA-binding domain">DNA-binding domain</a>, ETS, which binds to the <a href="/wiki/Consensus_sequence" title="Consensus sequence">consensus DNA sequence</a>, 5-GGAA/T-3 within a 9-to-10 bp sequence, in the target genes it regulates.<sup id="cite_ref-pmid22578774_5-2" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28450705_8-0" class="reference"><a href="#cite_note-pmid28450705-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> ETV6 <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interacts</a> with other proteins that regulate the differentiation and growth of cells. It binds to and thereby inhibits <a href="/wiki/FLI1" title="FLI1">FLI1</a>, another member of the <a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS transcription factor family</a>, which is active in promoting the maturation of blood <a href="/wiki/Platelet" title="Platelet">platelet</a>-forming <a href="/wiki/Megakaryocytes" class="mw-redirect" title="Megakaryocytes">megakaryocytes</a> and blocking the <a href="/wiki/Cellular_differentiation" title="Cellular differentiation">Cellular differentiation</a> of <a href="/wiki/Erythroblasts" class="mw-redirect" title="Erythroblasts">erythroblasts</a> into <a href="/wiki/Red_blood_cells" class="mw-redirect" title="Red blood cells">red blood cells</a>; this results in the excessive proliferation and abnormal <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphology</a> of erythroblasts.<sup id="cite_ref-pmid9651344_9-0" class="reference"><a href="#cite_note-pmid9651344-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28416505_7-1" class="reference"><a href="#cite_note-pmid28416505-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> ETV6 likewise binds to <a href="/wiki/HTATIP" class="mw-redirect" title="HTATIP">HTATIP</a>, a <a href="/wiki/Histone_acetyl_transferase" class="mw-redirect" title="Histone acetyl transferase">histone acetyl transferase</a> that regulates the expression of various genes involved in gene transcription, <a href="/wiki/DNA_repair" title="DNA repair">DNA repair</a>, and cellular <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>; this binding promotes the transcription-repressing activity of ETV6.<sup id="cite_ref-pmid12737628_10-0" class="reference"><a href="#cite_note-pmid12737628-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Medical_significance">Medical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=3" title="Edit section: Medical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Inherited_mutations">Inherited mutations</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=4" title="Edit section: Inherited mutations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Rare <a href="/wiki/Missense_mutation" title="Missense mutation">missense</a> and other <a href="/wiki/Mutation#By_effect_on_function" title="Mutation">loss of function</a> mutations in ETV6 cause thrombocytopenia 5, an <a href="/wiki/Autosomal_dominant" class="mw-redirect" title="Autosomal dominant">autosomal dominant</a> familial disease characterized by variable <a href="/wiki/Thrombocytopenia" title="Thrombocytopenia">thrombocytopenia</a> (<a href="/wiki/Blood_platelet" class="mw-redirect" title="Blood platelet">blood platelet</a> counts from 5% to 90% of normal), mild to modest bleeding tendencies, and <a href="/wiki/Bone_marrow" title="Bone marrow">bone marrow</a> biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell <a href="/wiki/Macrocytosis" title="Macrocytosis">macrocytosis</a>.<sup id="cite_ref-pmid28416505_7-2" class="reference"><a href="#cite_note-pmid28416505-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid27248996_11-0" class="reference"><a href="#cite_note-pmid27248996-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Thrombocytopenia 5 is associated with an increased incidence of developing hematological (e.g. <a href="/wiki/Chronic_myelomonocytic_leukemia" title="Chronic myelomonocytic leukemia">chronic myelomonocytic leukemia</a>, <a href="/wiki/Acute_myelocytic_leukemia" class="mw-redirect" title="Acute myelocytic leukemia">acute myelocytic leukemia</a>, B cell <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">acute lymphoblastic leukemia</a>, mixed phenotype acute leukemia, <a href="/wiki/Myelodysplastic_syndrome" title="Myelodysplastic syndrome">Myelodysplastic syndrome</a>, and <a href="/wiki/Multiple_myeloma" title="Multiple myeloma">multiple myeloma</a>) and non-hematological (e.g. skin and colon) cancers as well as non-malignant diseases such as refractory <a href="/wiki/Anemia" title="Anemia">anemia</a> <a href="/wiki/Myopathies" class="mw-redirect" title="Myopathies">myopathies</a>, and <a href="/wiki/Gastroesophageal_reflux_disease" title="Gastroesophageal reflux disease">gastroesophageal reflux disease</a>.<sup id="cite_ref-pmid27248996_11-1" class="reference"><a href="#cite_note-pmid27248996-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid25581430_12-0" class="reference"><a href="#cite_note-pmid25581430-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>Two unrelated kindreds were found to have <a href="/wiki/Autosomal_dominant" class="mw-redirect" title="Autosomal dominant">autosomal dominant</a> inherited mutations in the <i>ETV6</i> gene, one family with a germline DNA substitution termed L349P that lead to replacing leucine with proline at amino acid 349 in the DNA binding domain of the ETV6, the second, termed N385fs, in germline DNA caused the lose of five base pairs <i>ETV6</i> and a truncated ETV6 protein. Both mutant proteins failed to enter cell nuclei normally and had a reduced capacity to target genes regulated by the normal ETV6 protein. Afflicted members of these families had low platelet counts (i.e. thrombocytopenia) and <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">acute lymphoblastic leukemia</a>. Fifteen members of the two kindreds had thrombocytopenia, five of whom also had acute lymphoblastic leukemia. The L249P kindred also had one family member with <a href="/wiki/Renal_cell_carcinoma" title="Renal cell carcinoma">renal cell carcinoma</a> and another family member with <a href="/wiki/Duodenal_cancer" title="Duodenal cancer">Duodenal cancer</a>. The relationship of these two cancers to the L249P mutation has not been investigated. In all events these two familial thrombocytopenia syndromes appear distinctly different than the thrombocytopenia 5 syndrome.<sup id="cite_ref-pmid26102509_13-0" class="reference"><a href="#cite_note-pmid26102509-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Treatment">Treatment</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=5" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Family members with thrombocytopenia 5 need to be regularly monitored with <a href="/wiki/Complete_blood_count" title="Complete blood count">complete blood count</a> and <a href="/wiki/Blood_film" class="mw-redirect" title="Blood film">blood smear</a> screenings to detect the early changes brought on by the malignant transformations of this disease into hematological neoplasms. Patients who developed these transformations have generally been treated similarly to patients who have the same hematological neoplasms but on a non-familial basis. Patients developing non-malignant hematological or non-hematological solid tumor manifestations of thrombocytopenia 5 are also treated like to patients with the same but no-familial disease.<sup id="cite_ref-pmid27248996_11-2" class="reference"><a href="#cite_note-pmid27248996-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid25581430_12-1" class="reference"><a href="#cite_note-pmid25581430-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>The acute lymphoblastic leukemia associated with L349P or N385fs mutations in <i>ETV6</i> appeared far less sensitive to standard <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapy</a> for acute lymphoblastic leukemia with 2 among 3 family members moving rather quickly from chemotherapy to <a href="/wiki/Bone_marrow_transplantation" class="mw-redirect" title="Bone marrow transplantation">bone marrow transplantation</a> and the third family member expiring. This suggest that these mutation-related forms of acute lymphoblastic leukemia require aggressive therapy.<sup id="cite_ref-pmid26102509_13-1" class="reference"><a href="#cite_note-pmid26102509-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Acquired_mutations">Acquired mutations</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=6" title="Edit section: Acquired mutations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <i>ETV6</i> gene is prone to develop a wide range of acquired mutations in hematological precursor cells that lead to various types of <a href="/wiki/Leukemia" title="Leukemia">leukemia</a> and/or <a href="/wiki/Lymphoma" title="Lymphoma">lymphoma</a>. It may also suffer a smaller number of mutations in non-hematological tissues that leads to <a href="/wiki/Solid_tumors" class="mw-redirect" title="Solid tumors">solid tumors</a>. These mutations involve <a href="/wiki/Chromosome_translocation" class="mw-redirect" title="Chromosome translocation">chromosome translocations</a> which fuse the <i>ETV6</i> on chromosome 12's the short (i.e. "p") arm ("q" stands for long arm) at position p13.2 (site notation: 12p12.2) near to a second gene on another chromosome or, more rarely, its own chromosome. This creates a <a href="/wiki/Fusion_gene" title="Fusion gene">fusion gene</a> of the <a href="/wiki/Oncogene" title="Oncogene">oncogene</a> category which encodes a <a href="/wiki/Chimeric_protein" class="mw-redirect" title="Chimeric protein">chimeric protein</a> that promotes the malignant growth of its parent cells. It may be unclear which portion of the newly formed oncoprotein contributes to the ensuing malignancy but fusions between ETV6 and proteins with <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinase</a> activity generally are converted from a protein with tightly regulated tyrosine kinase activity to an uncontrolled and continuously active tyrosine kinase that thereby promotes the malignant transformation of its parent cells.<sup id="cite_ref-pmid28028030_14-0" class="reference"><a href="#cite_note-pmid28028030-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Hematological_malignancies">Hematological malignancies</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=7" title="Edit section: Hematological malignancies"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The following table lists the more frequently occurring genes to which ETV6 fuses, the function of these genes, these genes' chromosomal locations, the notation designating the most common sites of the translocations of these fused genes, and the malignancies resulting from these translocations. These translocation mutations commonly occur in <a href="/wiki/Cell_potency#Pluripotency" title="Cell potency">pluripotent</a> <a href="/wiki/Hematopoietic_stem_cell" title="Hematopoietic stem cell">hematopoietic stem cells</a> that differentiate into various types of mature hematological cells. Consequently, a given mutation may lead to various types of <a href="/wiki/Tumors_of_the_hematopoietic_and_lymphoid_tissues" title="Tumors of the hematopoietic and lymphoid tissues">hematological malignancies</a>.<sup id="cite_ref-pmid22578774_5-3" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28028030_14-1" class="reference"><a href="#cite_note-pmid28028030-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), homeobox protein type of transcription factor (homeobox protein), acute lymphocytic leukemia (ALL), Philadelphia chromosome negative chronic myelogenous leukemia (Ph(-)CML), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), and acute myeloid leukemia (AML). The presence of <i>ETV6</i> gene mutations in myelodysplastic syndromes is associated with shortened survival.<sup id="cite_ref-pmid26769228_15-0" class="reference"><a href="#cite_note-pmid26769228-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable"> <tbody><tr> <th>Gene</th> <th>function</th> <th>location</th> <th>notation</th> <th>malignancies</th> <th></th> <th>gene</th> <th>function</th> <th>location</th> <th>notation</th> <th>malignancies </th></tr> <tr> <td><i><a href="/wiki/PDGFRA" class="mw-redirect" title="PDGFRA">PDGFRA</a></i></td> <td><a href="/wiki/Tyrosine_kinase_receptor" class="mw-redirect" title="Tyrosine kinase receptor">TK receptor</a></td> <td>4q12</td> <td>t(4;12)(q27?3;p13)</td> <td>40% to 50% of <a href="/wiki/Clonal_eosinophilia" class="mw-redirect" title="Clonal eosinophilia">clonal eosinophilia</a> patients</td> <td></td> <td><i><a href="/wiki/PDGFRB" title="PDGFRB">PDGFRB</a></i></td> <td><a href="/wiki/Tyrosine_kinase_receptor" class="mw-redirect" title="Tyrosine kinase receptor">TK receptor</a></td> <td>5q32</td> <td>t(5;12)(q31-33;p13)</td> <td>rare <a href="/wiki/Clonal_eosinophilia" class="mw-redirect" title="Clonal eosinophilia">clonal eosinophilia</a> patients </td></tr> <tr> <td><i><a href="/wiki/FLT3" class="mw-redirect" title="FLT3">FLT3</a></i></td> <td><a href="/wiki/Tyrosine_kinase_receptor" class="mw-redirect" title="Tyrosine kinase receptor">TK receptor</a></td> <td>13q12.2</td> <td>t(12;13)(q13.1;p12.3-13)</td> <td>rare <a href="/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia">AML</a>, <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">ALL</a>, and <a href="/wiki/Clonal_eosinophilia" class="mw-redirect" title="Clonal eosinophilia">clonal eosinophilia</a> patients</td> <td></td> <td><i><a href="/wiki/ABL1" class="mw-redirect" title="ABL1">ABL1</a></i></td> <td><a href="/wiki/Non-receptor_tyrosine_kinase" title="Non-receptor tyrosine kinase">non-receptor TK</a></td> <td>9q34.12</td> <td>t(9;12)(q34;p13)</td> <td>rare <a href="/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia">AML</a>, B-cell or T-cell <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">ALL</a>, Ph(-)<a href="/wiki/Chronic_myelogenous_leukemia" title="Chronic myelogenous leukemia">CML</a> patients </td></tr> <tr> <td><i><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></i></td> <td><a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a></td> <td>21q22.12</td> <td>t(12;21)(p13;q22)</td> <td>20-25% of pediatric <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">ALL</a> patients</td> <td></td> <td><i><a href="/wiki/PAX5" title="PAX5">PAX5</a></i></td> <td><a href="/wiki/Homeobox#Biological_function" title="Homeobox">homeobox protein</a></td> <td>9p13.2</td> <td>t(9;12)(q11;p13)</td> <td>1% of pediatric <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">ALL</a> patients </td></tr> <tr> <td><i><a href="/wiki/MNX1" title="MNX1">MNX1</a></i></td> <td><a href="/wiki/Homeobox#Biological_function" title="Homeobox">homeobox protein</a></td> <td>7q36.3</td> <td>t(7:12)(q36;p13)</td> <td>20-30% of pediatric <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">ALL</a> patients less than 18 months old</td> <td></td> <td><i><a href="/wiki/MECOM" title="MECOM">MECOM</a></i></td> <td><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factor</a></td> <td>3q26.2</td> <td>t(3;12)(q26;p13)</td> <td>rare <a href="/wiki/Myelodysplastic_syndrome" title="Myelodysplastic syndrome">MDS</a>, <a href="/wiki/Myeloproliferative_neoplasm" title="Myeloproliferative neoplasm">MPN</a>, and <a href="/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia">AML</a> patients </td></tr> </tbody></table> <p>In addition to the fusion gene-producing translocations given in the table, <i>ETV6</i> has been reported to fuse with other genes in very rare cases (i.e. 1-10 published reports). These translocations lead to one or more of the same types of hematological malignancies listed in the table. Thus, the <i>ETV6</i> gene reportedly forms translocation-induced fusion genes with:<sup id="cite_ref-pmid22578774_5-4" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <b>a)</b> tyrosine kinase receptor gene <i><a href="/wiki/FGFR3" class="mw-redirect" title="FGFR3">FGFR3</a></i>; <b>b)</b> non-receptor tyrosine kinase genes <i><a href="/wiki/ABL2" title="ABL2">ABL2</a>, <a href="/wiki/NTRK3" class="mw-redirect" title="NTRK3">NTRK3</a>, <a href="/wiki/JAK2" class="mw-redirect" title="JAK2">JAK2</a>, <a href="/wiki/SYK_(gene)" class="mw-redirect" title="SYK (gene)">SYK</a>, <a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a>,</i> and <i><a href="/wiki/LYN" title="LYN">LYN</a></i>; <b>c)</b> transcription factor genes <i><a href="/wiki/MN1_(gene)" title="MN1 (gene)">MN1</a></i> and <i><a href="/wiki/PER1" class="mw-redirect" title="PER1">PER1</a></i>; <b>d)</b> homeobox protein transcription factor <i><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">CDX2</a></i>; <b>e)</b> Protein tyrosine phosphatase receptor-type R gene <i><a href="/wiki/PTPRR" title="PTPRR">PTPRR</a></i>;<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> <b>f)</b> transcriptional coactivator for nuclear hormone receptors gene <a href="/wiki/NCOA2" class="mw-redirect" title="NCOA2">NCOA2</a>; <b>f)</b> <a href="/wiki/Immunoglobulin_heavy_chain" title="Immunoglobulin heavy chain">Immunoglobulin heavy chain</a> gene IGH;<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> <b>g)</b> enzyme genes <i><a href="/wiki/Tubulin%E2%80%94tyrosine_ligase" title="Tubulin—tyrosine ligase">TTL</a></i> (adds and removes tyrosine residues on <a href="/wiki/Tubulin#α-Tubulin" title="Tubulin">α-tubulin</a>),<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> <i><a href="/wiki/GOT1" title="GOT1">GOT1</a></i> (an <a href="/wiki/Aspartate_transaminase" title="Aspartate transaminase">Aspartate transaminase</a>), and <a href="/wiki/ACSL6" title="ACSL6">ACSL6</a> (a <a href="/wiki/Long-chain-fatty-acid%E2%80%94CoA_ligase" title="Long-chain-fatty-acid—CoA ligase">Long-chain-fatty-acid—CoA ligase</a>); <b>h)</b> transporter gene <i><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a></i> (binds to <a href="/wiki/Ligand" title="Ligand">ligand</a>-bound <a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">aryl hydrocarbon receptor</a> to aid in its movement to the nucleus where it promotes the expression of genes involved in xenobiotic metabolism); <b>i)</b> unknown function genes <i>CHIC2</i>,<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> <i>MDS2</i>,<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> <a href="/wiki/FCHO2" title="FCHO2">FCHO2</a><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> and <i><a href="/wiki/BAZ2A" title="BAZ2A">BAZ2A</a></i>.;<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> and <b>j)</b> non-annotated gene <i>STL</i> (which has no long <a href="/wiki/Open_reading_frame" title="Open reading frame">open reading frame</a><sup id="cite_ref-pmid9087565_23-0" class="reference"><a href="#cite_note-pmid9087565-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup>). </p><p>At least 9 <a href="/wiki/Frameshift_mutation" title="Frameshift mutation">frameshift mutations</a> in the'<i>ETV6</i> gene have been associated with ~12% of adult T cell <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">Acute lymphoblastic leukemia</a> cases. These mutations involve insertions or deletions in the gene that lead to its encoding a truncated and therefore inactive ETV6 protein. These mutations commonly occur alongside mutations in another oncogene, <i><a href="/wiki/NOTCH1" class="mw-redirect" title="NOTCH1">NOTCH1</a></i>, which is associated with T cell acute lymphoblastic lymphoma quite independently of ETV6. It is suggested that suppressor mutations in the <i>ETV6</i> gene may be a contributing factor in the development ant/or progression of this leukemia type.<sup id="cite_ref-pmid28450705_8-1" class="reference"><a href="#cite_note-pmid28450705-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22162831_24-0" class="reference"><a href="#cite_note-pmid22162831-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28115368_25-0" class="reference"><a href="#cite_note-pmid28115368-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading5"><h5 id="Treatment_2">Treatment</h5><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=8" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Patients developing hematological malignancies secondary to the <i>ETV6</i> gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with <a href="/wiki/Tyrosine_kinase_inhibitors" class="mw-redirect" title="Tyrosine kinase inhibitors">tyrosine kinase inhibitors</a>.<sup id="cite_ref-pmid26404639_26-0" class="reference"><a href="#cite_note-pmid26404639-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> For example, patients with clonal eosinophilias due to <i><a href="/wiki/PDGFRA#Myeloid_and_lymphoid_cells" class="mw-redirect" title="PDGFRA">PDGFRA</a></i> or <i><a href="/wiki/PDGFRB#PDGFRB-ETV6_translocations" title="PDGFRB">PDGFRB</a></i> fusion genes experience long-term, complete remission when treated with are highly sensitive tyrosine kinase inhibitor, <a href="/wiki/Gleevec" class="mw-redirect" title="Gleevec">gleevec</a>.<sup id="cite_ref-pmid28028030_14-2" class="reference"><a href="#cite_note-pmid28028030-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a>, <a href="/wiki/Entrectinib" title="Entrectinib">entrectinib</a>, <a href="/wiki/Merestinib" title="Merestinib">merestinib</a>, and server other broadly acting tyrosine kinase inhibitors target the <i>NTRK3</i> gene. Many of these drugs are in phase 1 or phase 2 <a href="/wiki/Phases_of_clinical_research" title="Phases of clinical research">clinical trials</a> for the treatment of <i>ETV6-NTRK3</i>-related solid tumors and may ultimately prove useful for treating hematologic malignancies associated with this fusion gene.<sup id="cite_ref-pmid28174090_27-0" class="reference"><a href="#cite_note-pmid28174090-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Clinical trials have found that the first generation tyrosine kinase inhibitors <a href="/wiki/Sorafenib" title="Sorafenib">sorafenib</a>, <a href="/wiki/Sunitinib" title="Sunitinib">sunitinib</a>, <a href="/wiki/Midostaurin" title="Midostaurin">midostaurin</a>, <a href="/wiki/Lestaurtinib" title="Lestaurtinib">lestaurtinib</a> have shown some promise in treating <a href="/wiki/Acute_myelogenous_leukemia" class="mw-redirect" title="Acute myelogenous leukemia">acute myelogenous leukemia</a> associated with the <i>FLT3-TKI</i> fusion gene; the second generation tyrosine kinase inhibitors <a href="/wiki/Quizartinib" title="Quizartinib">quizartinib</a> and <a href="/wiki/Crenolanib" title="Crenolanib">crenolanib</a> which are highly selective in inhibiting the FLT3 protein, have shown significant promise in treating relapsed and refractory acute myelogenous leukemia related to the <i>FLT3-TKI</i> fusion gene.<sup id="cite_ref-pmid28538663_28-0" class="reference"><a href="#cite_note-pmid28538663-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> One patient with <i>ETV6-FLT3</i>-related myeloid/lymphoid neoplasm obtained a short term remission on sunitinib and following relapse, on sorafenib suggesting that the cited FLT3 protein tyrosine kinase inhibitors may prove useful for treating <i>ETV6-FLT</i>-related hematologic malignancies.<sup id="cite_ref-pmid21705501_29-0" class="reference"><a href="#cite_note-pmid21705501-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Two patients suffering hematologic malignancies related to <i>PCM1-JAK2</i> or <i>BCR-JAK2</i> fusion genes experienced complete and cytogenetic remissions in response to the tyrosine kinase inhibitor <a href="/wiki/Ruxolitinib" title="Ruxolitinib">ruxolitinib</a>; while both remissions were short-term (12 months), these results suggest that tyrosine kinase inhibitors that target JAK2 may be of some use for treating hematologic malignancies associated with <i>ETV6-JAK2</i> fusion stems.<sup id="cite_ref-pmid28028030_14-3" class="reference"><a href="#cite_note-pmid28028030-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> An inhibitor of SYK tyrosine kinase, TAK-659 is currently undergoing Phase I clinical trials for advanced lymphoma malignancies and may prove to be useful in treating this disease when associated with the <i>ETV6-SYK</i> fusion gene.<sup id="cite_ref-pmid27839918_30-0" class="reference"><a href="#cite_note-pmid27839918-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> It is possible that hematological malignancies associated with <i>ETV6</i> gene fusions to either the <i>SYK</i> or <i>FRK</i> tyrosine kinase genes may someday be shown susceptible to tyrosine kinase inhibitor therapy. However, children with <i>ETV6-RUNX1</i>-associated <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">acute lymphoblastic leukemia</a> are in an especially good-risk subgroup and therefore have been almost uniformly treated with standard-risk <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapy</a> protocols.<sup id="cite_ref-pmid24319172_31-0" class="reference"><a href="#cite_note-pmid24319172-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p><p>Hematological malignancies associated with <i>ETY6</i> gene fusions to other transcription factor genes appear to reflect a loss or gain in function of <i>ETV6</i> and/or the other genes in regulating expression of their target genes; this results in the formation or lack of formation of products which influence cell growth, proliferation, and/or survival. In vitro studies of <i>ETV6-RUNX, ETV6-MN1, ETV6-PER1</i>, and <i>ETV6-MECOM</i> fusion genes support this notion. Thus, the <i>ETV6-MECOM</i> fusion gene is overexpressed because it is driven by the <a href="/wiki/Promoter_(genetics)" title="Promoter (genetics)">promoter</a> derived from <i>ETV6</i><sup id="cite_ref-pmid22578774_5-5" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> whereas the <i>ETV6-RUNX, ETV6-MN1</i>, and <i> ETV6-PER1</i> fusion genes produce chimeric proteins which lack ETV6 protein's gene-suppressing activity.<sup id="cite_ref-pmid24066765_32-0" class="reference"><a href="#cite_note-pmid24066765-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> The chimeric protein products of <i>ETV6</i> gene fusions with <i>ARNT, TTL, BA22A, FCHO2, MDS2</i>, and <i>CHIC2</i> likewise lack ETV6 protein's transcription factor activity.<sup id="cite_ref-pmid24066765_32-1" class="reference"><a href="#cite_note-pmid24066765-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> Gene fusions between <i>ETV6</i> and the homeobox gens (i.e. <i>CDX2, PAX5,</i> and MNX1) produce chimeric proteins with lack either ETV6s and/or CDX2s, PAX5s or MNX1s transcription factor activity.<sup id="cite_ref-pmid22578774_5-6" class="reference"><a href="#cite_note-pmid22578774-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In all events, hematological malignancies associated with these fusion genes have been treated with standard chemotherapy protocols selected on the basis of the malignancies <a href="/wiki/Phenotype" title="Phenotype">phenotype</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Solid_Tumors">Solid Tumors</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=9" title="Edit section: Solid Tumors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in the <i>ETV6</i> gene are also associated with <a href="/wiki/Solid_tumor" class="mw-redirect" title="Solid tumor">solid tumors</a>. In particular, the <i>ETV6-<a href="/wiki/NTRK3" class="mw-redirect" title="NTRK3">NTRK3</a></i> fusion gene occurs in and is thought or proposed to drive certain types of cancers. These cancers include <a href="/wiki/Breast_cancer_classification" title="Breast cancer classification">secretory breast cancer</a> (also termed juvenile breast cancer), <a href="/wiki/Mammary_analogue_secretory_carcinoma" title="Mammary analogue secretory carcinoma">mammary analogue secretory carcinoma</a> of the <a href="/wiki/Parotid_gland" title="Parotid gland">parotid</a> and other <a href="/wiki/Salivary_glands" class="mw-redirect" title="Salivary glands">salivary glands</a>, <a href="/wiki/Fibrosarcoma#Infantile-type" title="Fibrosarcoma">congenital fibrosarcoma</a>, <a href="/wiki/Congenital_mesoblastic_nephroma" class="mw-redirect" title="Congenital mesoblastic nephroma">congenital mesoblastic nephroma</a>, <a href="/wiki/Inflammatory_myofibroblastic_tumor" class="mw-redirect" title="Inflammatory myofibroblastic tumor">inflammatory myofibroblastic tumor</a>, and radiation-induced <a href="/wiki/Papillary_thyroid_carcinoma" class="mw-redirect" title="Papillary thyroid carcinoma">papillary thyroid carcinoma</a>.<sup id="cite_ref-pmid28450705_8-2" class="reference"><a href="#cite_note-pmid28450705-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12450792_33-0" class="reference"><a href="#cite_note-pmid12450792-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28174090_27-1" class="reference"><a href="#cite_note-pmid28174090-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28060365_36-0" class="reference"><a href="#cite_note-pmid28060365-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24066765_32-2" class="reference"><a href="#cite_note-pmid24066765-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid27259007_37-0" class="reference"><a href="#cite_note-pmid27259007-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Treatment_3">Treatment</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=10" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The treatment of <i>ETV6</i> gene-associated solid tumors has not advanced as far as that for <i>ETV6</i> gene-associated hematological malignancies. It is proposed that <a href="/wiki/Tyrosine_kinase_inhibitor" title="Tyrosine kinase inhibitor">tyrosine kinase inhibitors</a> with specificity for NTRK3's tyrosine kinase activity in <i>ETV6-NTRK3</i> gene-associated solid tumors may be of therapeutic usefulness. <a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a>, a pan-NTRK as well as an <a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a> and <a href="/wiki/ROS1" title="ROS1">ROS1</a> tyrosine kinase inhibitor has been found useful in treating a single patient with <i>ETV6-NRTK3</i> fusion gene-associated <a href="/wiki/Mammary_analogue_secretory_carcinoma#Clinical_course_and_treatment" title="Mammary analogue secretory carcinoma">mammary analogue secretory carcinoma</a> and lends support to the clinical development of NTRK3-directed tyrosine kinase inhibitors to treat ETV6-NTRK3 fusion protein associated malignancies.<sup id="cite_ref-pmid28174090_27-2" class="reference"><a href="#cite_note-pmid28174090-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Three clinical trials are in the recruitment phase for determining the efficacy of treating a wide range of solid tumors associated with mutated, overactive tyrosine kinase proteins, including the ETV6-TRK3 protein, with <a href="/wiki/Larotrectinib" title="Larotrectinib">larotrectinib</a>, a non-selective inhibitor of NTRK1, NTRK2, and NTRK3 tyrosine kinases.<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=11" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/ETV6-NTRK3_gene_fusion" title="ETV6-NTRK3 gene fusion">ETV6-NTRK3 gene fusion</a></li> <li><a href="/wiki/TEL-JAK2" title="TEL-JAK2">TEL-JAK2</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=12" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000139083">GRCh38: Ensembl release 89: ENSG00000139083</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000030199">GRCm38: Ensembl release 89: ENSMUSG00000030199</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2120">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D2120&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=14011">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D14011&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid22578774-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid22578774_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid22578774_5-6"><sup><i><b>g</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDe_BraekeleerDouet-GuilbertMorelLe_Bris2012" class="citation journal cs1">De Braekeleer E, Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, De Braekeleer M (August 2012). "ETV6 fusion genes in hematological malignancies: a review". <i>Leukemia Research</i>. <b>36</b> (8): 945–61. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.leukres.2012.04.010">10.1016/j.leukres.2012.04.010</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22578774">22578774</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Leukemia+Research&rft.atitle=ETV6+fusion+genes+in+hematological+malignancies%3A+a+review&rft.volume=36&rft.issue=8&rft.pages=945-61&rft.date=2012-08&rft_id=info%3Adoi%2F10.1016%2Fj.leukres.2012.04.010&rft_id=info%3Apmid%2F22578774&rft.aulast=De+Braekeleer&rft.aufirst=E&rft.au=Douet-Guilbert%2C+N&rft.au=Morel%2C+F&rft.au=Le+Bris%2C+MJ&rft.au=Basinko%2C+A&rft.au=De+Braekeleer%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">Online Mendelian Inheritance in Man</a> (OMIM): <a rel="nofollow" class="external text" href="https://omim.org/entry/600618">ETS Variant Gene 6; ETV6 - 600618</a></span> </li> <li id="cite_note-pmid28416505-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid28416505_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid28416505_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid28416505_7-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSongdejRao2017" class="citation journal cs1">Songdej N, Rao AK (May 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445569">"Hematopoietic transcription factor mutations: important players in inherited platelet defects"</a>. <i>Blood</i>. <b>129</b> (21): 2873–2881. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-11-709881">10.1182/blood-2016-11-709881</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445569">5445569</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28416505">28416505</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Hematopoietic+transcription+factor+mutations%3A+important+players+in+inherited+platelet+defects&rft.volume=129&rft.issue=21&rft.pages=2873-2881&rft.date=2017-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5445569%23id-name%3DPMC&rft_id=info%3Apmid%2F28416505&rft_id=info%3Adoi%2F10.1182%2Fblood-2016-11-709881&rft.aulast=Songdej&rft.aufirst=N&rft.au=Rao%2C+AK&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5445569&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28450705-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid28450705_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid28450705_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid28450705_8-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSizemorePitarresiBalakrishnanOstrowski2017" class="citation journal cs1">Sizemore GM, Pitarresi JR, Balakrishnan S, Ostrowski MC (June 2017). "The ETS family of oncogenic transcription factors in solid tumours". <i>Nature Reviews. Cancer</i>. <b>17</b> (6): 337–351. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnrc.2017.20">10.1038/nrc.2017.20</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28450705">28450705</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:32483397">32483397</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Reviews.+Cancer&rft.atitle=The+ETS+family+of+oncogenic+transcription+factors+in+solid+tumours&rft.volume=17&rft.issue=6&rft.pages=337-351&rft.date=2017-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A32483397%23id-name%3DS2CID&rft_id=info%3Apmid%2F28450705&rft_id=info%3Adoi%2F10.1038%2Fnrc.2017.20&rft.aulast=Sizemore&rft.aufirst=GM&rft.au=Pitarresi%2C+JR&rft.au=Balakrishnan%2C+S&rft.au=Ostrowski%2C+MC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid9651344-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9651344_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKwiatkowskiBastianBauerTsai1998" class="citation journal cs1">Kwiatkowski BA, Bastian LS, Bauer TR, Tsai S, Zielinska-Kwiatkowska AG, Hickstein DD (July 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.28.17525">"The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity"</a>. <i>The Journal of Biological Chemistry</i>. <b>273</b> (28): 17525–30. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.28.17525">10.1074/jbc.273.28.17525</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9651344">9651344</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+ets+family+member+Tel+binds+to+the+Fli-1+oncoprotein+and+inhibits+its+transcriptional+activity&rft.volume=273&rft.issue=28&rft.pages=17525-30&rft.date=1998-07&rft_id=info%3Adoi%2F10.1074%2Fjbc.273.28.17525&rft_id=info%3Apmid%2F9651344&rft.aulast=Kwiatkowski&rft.aufirst=BA&rft.au=Bastian%2C+LS&rft.au=Bauer%2C+TR&rft.au=Tsai%2C+S&rft.au=Zielinska-Kwiatkowska%2C+AG&rft.au=Hickstein%2C+DD&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.273.28.17525&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid12737628-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12737628_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNordentoftJørgensen2003" class="citation journal cs1">Nordentoft I, Jørgensen P (August 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223570">"The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor"</a>. <i>The Biochemical Journal</i>. <b>374</b> (Pt 1): 165–73. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2FBJ20030087">10.1042/BJ20030087</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223570">1223570</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12737628">12737628</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Biochemical+Journal&rft.atitle=The+acetyltransferase+60+kDa+trans-acting+regulatory+protein+of+HIV+type+1-interacting+protein+%28Tip60%29+interacts+with+the+translocation+E26+transforming-specific+leukaemia+gene+%28TEL%29+and+functions+as+a+transcriptional+co-repressor&rft.volume=374&rft.issue=Pt+1&rft.pages=165-73&rft.date=2003-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1223570%23id-name%3DPMC&rft_id=info%3Apmid%2F12737628&rft_id=info%3Adoi%2F10.1042%2FBJ20030087&rft.aulast=Nordentoft&rft.aufirst=I&rft.au=J%C3%B8rgensen%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1223570&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid27248996-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid27248996_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid27248996_11-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid27248996_11-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBannonDiNardo2016" class="citation journal cs1">Bannon SA, DiNardo CD (May 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926372">"Hereditary Predispositions to Myelodysplastic Syndrome"</a>. <i>International Journal of Molecular Sciences</i>. <b>17</b> (6): 838. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fijms17060838">10.3390/ijms17060838</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926372">4926372</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27248996">27248996</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Molecular+Sciences&rft.atitle=Hereditary+Predispositions+to+Myelodysplastic+Syndrome&rft.volume=17&rft.issue=6&rft.pages=838&rft.date=2016-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4926372%23id-name%3DPMC&rft_id=info%3Apmid%2F27248996&rft_id=info%3Adoi%2F10.3390%2Fijms17060838&rft.aulast=Bannon&rft.aufirst=SA&rft.au=DiNardo%2C+CD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4926372&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid25581430-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid25581430_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid25581430_12-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangChurpekKeelWalsh2015" class="citation journal cs1">Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura A (February 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540357">"Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy"</a>. <i>Nature Genetics</i>. <b>47</b> (2): 180–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng.3177">10.1038/ng.3177</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540357">4540357</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25581430">25581430</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Germline+ETV6+mutations+in+familial+thrombocytopenia+and+hematologic+malignancy&rft.volume=47&rft.issue=2&rft.pages=180-5&rft.date=2015-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4540357%23id-name%3DPMC&rft_id=info%3Apmid%2F25581430&rft_id=info%3Adoi%2F10.1038%2Fng.3177&rft.aulast=Zhang&rft.aufirst=MY&rft.au=Churpek%2C+JE&rft.au=Keel%2C+SB&rft.au=Walsh%2C+T&rft.au=Lee%2C+MK&rft.au=Loeb%2C+KR&rft.au=Gulsuner%2C+S&rft.au=Pritchard%2C+CC&rft.au=Sanchez-Bonilla%2C+M&rft.au=Delrow%2C+JJ&rft.au=Basom%2C+RS&rft.au=Forouhar%2C+M&rft.au=Gyurkocza%2C+B&rft.au=Schwartz%2C+BS&rft.au=Neistadt%2C+B&rft.au=Marquez%2C+R&rft.au=Mariani%2C+CJ&rft.au=Coats%2C+SA&rft.au=Hofmann%2C+I&rft.au=Lindsley%2C+RC&rft.au=Williams%2C+DA&rft.au=Abkowitz%2C+JL&rft.au=Horwitz%2C+MS&rft.au=King%2C+MC&rft.au=Godley%2C+LA&rft.au=Shimamura%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4540357&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid26102509-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid26102509_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid26102509_13-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTopkaVijaiWalshJacobs2015" class="citation journal cs1">Topka S, Vijai J, Walsh MF, Jacobs L, Maria A, Villano D, Gaddam P, Wu G, McGee RB, Quinn E, Inaba H, Hartford C, Pui CH, Pappo A, Edmonson M, Zhang MY, Stepensky P, Steinherz P, Schrader K, Lincoln A, Bussel J, Lipkin SM, Goldgur Y, Harit M, Stadler ZK, Mullighan C, Weintraub M, Shimamura A, Zhang J, Downing JR, Nichols KE, Offit K (June 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477877">"Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia"</a>. <i>PLOS Genetics</i>. <b>11</b> (6): e1005262. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pgen.1005262">10.1371/journal.pgen.1005262</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477877">4477877</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26102509">26102509</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+Genetics&rft.atitle=Germline+ETV6+Mutations+Confer+Susceptibility+to+Acute+Lymphoblastic+Leukemia+and+Thrombocytopenia&rft.volume=11&rft.issue=6&rft.pages=e1005262&rft.date=2015-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4477877%23id-name%3DPMC&rft_id=info%3Apmid%2F26102509&rft_id=info%3Adoi%2F10.1371%2Fjournal.pgen.1005262&rft.aulast=Topka&rft.aufirst=S&rft.au=Vijai%2C+J&rft.au=Walsh%2C+MF&rft.au=Jacobs%2C+L&rft.au=Maria%2C+A&rft.au=Villano%2C+D&rft.au=Gaddam%2C+P&rft.au=Wu%2C+G&rft.au=McGee%2C+RB&rft.au=Quinn%2C+E&rft.au=Inaba%2C+H&rft.au=Hartford%2C+C&rft.au=Pui%2C+CH&rft.au=Pappo%2C+A&rft.au=Edmonson%2C+M&rft.au=Zhang%2C+MY&rft.au=Stepensky%2C+P&rft.au=Steinherz%2C+P&rft.au=Schrader%2C+K&rft.au=Lincoln%2C+A&rft.au=Bussel%2C+J&rft.au=Lipkin%2C+SM&rft.au=Goldgur%2C+Y&rft.au=Harit%2C+M&rft.au=Stadler%2C+ZK&rft.au=Mullighan%2C+C&rft.au=Weintraub%2C+M&rft.au=Shimamura%2C+A&rft.au=Zhang%2C+J&rft.au=Downing%2C+JR&rft.au=Nichols%2C+KE&rft.au=Offit%2C+K&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4477877&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28028030-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid28028030_14-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid28028030_14-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid28028030_14-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid28028030_14-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFReiterGotlib2017" class="citation journal cs1">Reiter A, Gotlib J (February 2017). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-10-695973">"Myeloid neoplasms with eosinophilia"</a>. <i>Blood</i>. <b>129</b> (6): 704–714. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-10-695973">10.1182/blood-2016-10-695973</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28028030">28028030</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Myeloid+neoplasms+with+eosinophilia&rft.volume=129&rft.issue=6&rft.pages=704-714&rft.date=2017-02&rft_id=info%3Adoi%2F10.1182%2Fblood-2016-10-695973&rft_id=info%3Apmid%2F28028030&rft.aulast=Reiter&rft.aufirst=A&rft.au=Gotlib%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2016-10-695973&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid26769228-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid26769228_15-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGangatPatnaikTefferi2016" class="citation journal cs1">Gangat N, Patnaik MM, Tefferi A (January 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajh.24253">"Myelodysplastic syndromes: Contemporary review and how we treat"</a>. <i>American Journal of Hematology</i>. <b>91</b> (1): 76–89. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajh.24253">10.1002/ajh.24253</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26769228">26769228</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Journal+of+Hematology&rft.atitle=Myelodysplastic+syndromes%3A+Contemporary+review+and+how+we+treat&rft.volume=91&rft.issue=1&rft.pages=76-89&rft.date=2016-01&rft_id=info%3Adoi%2F10.1002%2Fajh.24253&rft_id=info%3Apmid%2F26769228&rft.aulast=Gangat&rft.aufirst=N&rft.au=Patnaik%2C+MM&rft.au=Tefferi%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fajh.24253&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/5801">"PTPRR protein tyrosine phosphatase, receptor type R (human0"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=PTPRR+protein+tyrosine+phosphatase%2C+receptor+type+R+%28human0&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F5801&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/3492">"IGH immunoglobulin heavy locus (human )"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=IGH+immunoglobulin+heavy+locus+%28human+%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F3492&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/150465">"TTL tubulin tyrosine ligase (human)"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=TTL+tubulin+tyrosine+ligase+%28human%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F150465&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/26511">"CHIC2 cysteine rich hydrophobic domain 2 (human)"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=CHIC2+cysteine+rich+hydrophobic+domain+2+%28human%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F26511&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/259283">"MDS2 myelodysplastic syndrome 2 translocation associated"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=MDS2+myelodysplastic+syndrome+2+translocation+associated&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F259283&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-21">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/115548">"FCHO2 FCH domain only 2"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=FCHO2+FCH+domain+only+2&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F115548&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/11176">"BAZ2A bromodomain adjacent to zinc finger domain 2A"</a>. <i>Entrez Gene</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=BAZ2A+bromodomain+adjacent+to+zinc+finger+domain+2A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F11176&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid9087565-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9087565_23-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSutoSatoSmithRowley1997" class="citation journal cs1">Suto Y, Sato Y, Smith SD, Rowley JD, Bohlander SK (April 1997). "A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line". <i>Genes, Chromosomes & Cancer</i>. <b>18</b> (4): 254–68. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28sici%291098-2264%28199704%2918%3A4%3C254%3A%3Aaid-gcc3%3E3.0.co%3B2-%23">10.1002/(sici)1098-2264(199704)18:4<254::aid-gcc3>3.0.co;2-#</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9087565">9087565</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:196600869">196600869</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes%2C+Chromosomes+%26+Cancer&rft.atitle=A+t%286%3B12%29%28q23%3Bp13%29+results+in+the+fusion+of+ETV6+to+a+novel+gene%2C+STL%2C+in+a+B-cell+ALL+cell+line&rft.volume=18&rft.issue=4&rft.pages=254-68&rft.date=1997-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A196600869%23id-name%3DS2CID&rft_id=info%3Apmid%2F9087565&rft_id=info%3Adoi%2F10.1002%2F%28sici%291098-2264%28199704%2918%3A4%3C254%3A%3Aaid-gcc3%3E3.0.co%3B2-%23&rft.aulast=Suto&rft.aufirst=Y&rft.au=Sato%2C+Y&rft.au=Smith%2C+SD&rft.au=Rowley%2C+JD&rft.au=Bohlander%2C+SK&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid22162831-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid22162831_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVan_VlierbergheAmbesi-ImpiombatoPerez-GarciaHaydu2011" class="citation journal cs1">Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A, Haydu JE, Rigo I, Hadler M, Tosello V, Della Gatta G, Paietta E, Racevskis J, Wiernik PH, Luger SM, Rowe JM, Rue M, Ferrando AA (December 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244026">"ETV6 mutations in early immature human T cell leukemias"</a>. <i>The Journal of Experimental Medicine</i>. <b>208</b> (13): 2571–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1084%2Fjem.20112239">10.1084/jem.20112239</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244026">3244026</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22162831">22162831</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Experimental+Medicine&rft.atitle=ETV6+mutations+in+early+immature+human+T+cell+leukemias&rft.volume=208&rft.issue=13&rft.pages=2571-9&rft.date=2011-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3244026%23id-name%3DPMC&rft_id=info%3Apmid%2F22162831&rft_id=info%3Adoi%2F10.1084%2Fjem.20112239&rft.aulast=Van+Vlierberghe&rft.aufirst=P&rft.au=Ambesi-Impiombato%2C+A&rft.au=Perez-Garcia%2C+A&rft.au=Haydu%2C+JE&rft.au=Rigo%2C+I&rft.au=Hadler%2C+M&rft.au=Tosello%2C+V&rft.au=Della+Gatta%2C+G&rft.au=Paietta%2C+E&rft.au=Racevskis%2C+J&rft.au=Wiernik%2C+PH&rft.au=Luger%2C+SM&rft.au=Rowe%2C+JM&rft.au=Rue%2C+M&rft.au=Ferrando%2C+AA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3244026&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28115368-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid28115368_25-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSanchez-MartinFerrando2017" class="citation journal cs1">Sanchez-Martin M, Ferrando A (March 2017). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-09-692582">"The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia"</a>. <i>Blood</i>. <b>129</b> (9): 1124–1133. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-09-692582">10.1182/blood-2016-09-692582</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28115368">28115368</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=The+NOTCH1-MYC+highway+toward+T-cell+acute+lymphoblastic+leukemia&rft.volume=129&rft.issue=9&rft.pages=1124-1133&rft.date=2017-03&rft_id=info%3Adoi%2F10.1182%2Fblood-2016-09-692582&rft_id=info%3Apmid%2F28115368&rft.aulast=Sanchez-Martin&rft.aufirst=M&rft.au=Ferrando%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2016-09-692582&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid26404639-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid26404639_26-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGotlib2015" class="citation journal cs1">Gotlib J (December 2015). "Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis". <i>Current Hematologic Malignancy Reports</i>. <b>10</b> (4): 351–61. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs11899-015-0280-3">10.1007/s11899-015-0280-3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26404639">26404639</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:36630735">36630735</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Hematologic+Malignancy+Reports&rft.atitle=Tyrosine+Kinase+Inhibitors+and+Therapeutic+Antibodies+in+Advanced+Eosinophilic+Disorders+and+Systemic+Mastocytosis&rft.volume=10&rft.issue=4&rft.pages=351-61&rft.date=2015-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A36630735%23id-name%3DS2CID&rft_id=info%3Apmid%2F26404639&rft_id=info%3Adoi%2F10.1007%2Fs11899-015-0280-3&rft.aulast=Gotlib&rft.aufirst=J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28174090-27"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid28174090_27-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid28174090_27-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid28174090_27-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKhotskayaHollaFaragoMills_Shaw2017" class="citation journal cs1">Khotskaya YB, Holla VR, Farago AF, Mills Shaw KR, Meric-Bernstam F, Hong DS (May 2017). "Targeting TRK family proteins in cancer". <i>Pharmacology & Therapeutics</i>. <b>173</b>: 58–66. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pharmthera.2017.02.006">10.1016/j.pharmthera.2017.02.006</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28174090">28174090</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4243668">4243668</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacology+%26+Therapeutics&rft.atitle=Targeting+TRK+family+proteins+in+cancer&rft.volume=173&rft.pages=58-66&rft.date=2017-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4243668%23id-name%3DS2CID&rft_id=info%3Apmid%2F28174090&rft_id=info%3Adoi%2F10.1016%2Fj.pharmthera.2017.02.006&rft.aulast=Khotskaya&rft.aufirst=YB&rft.au=Holla%2C+VR&rft.au=Farago%2C+AF&rft.au=Mills+Shaw%2C+KR&rft.au=Meric-Bernstam%2C+F&rft.au=Hong%2C+DS&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28538663-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid28538663_28-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTsapogasMooneyBrownRolink2017" class="citation journal cs1">Tsapogas P, Mooney CJ, Brown G, Rolink A (May 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485939">"The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis"</a>. <i>International Journal of Molecular Sciences</i>. <b>18</b> (6): 1115. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fijms18061115">10.3390/ijms18061115</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485939">5485939</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28538663">28538663</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Molecular+Sciences&rft.atitle=The+Cytokine+Flt3-Ligand+in+Normal+and+Malignant+Hematopoiesis&rft.volume=18&rft.issue=6&rft.pages=1115&rft.date=2017-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5485939%23id-name%3DPMC&rft_id=info%3Apmid%2F28538663&rft_id=info%3Adoi%2F10.3390%2Fijms18061115&rft.aulast=Tsapogas&rft.aufirst=P&rft.au=Mooney%2C+CJ&rft.au=Brown%2C+G&rft.au=Rolink%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5485939&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid21705501-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21705501_29-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWalzErbenRitterBloor2011" class="citation journal cs1">Walz C, Erben P, Ritter M, Bloor A, Metzgeroth G, Telford N, Haferlach C, Haferlach T, Gesk S, Score J, Hofmann WK, Hochhaus A, Cross NC, Reiter A (August 2011). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2011-03-343426">"Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3"</a>. <i>Blood</i>. <b>118</b> (8): 2239–42. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2011-03-343426">10.1182/blood-2011-03-343426</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21705501">21705501</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Response+of+ETV6-FLT3-positive+myeloid%2Flymphoid+neoplasm+with+eosinophilia+to+inhibitors+of+FMS-like+tyrosine+kinase+3&rft.volume=118&rft.issue=8&rft.pages=2239-42&rft.date=2011-08&rft_id=info%3Adoi%2F10.1182%2Fblood-2011-03-343426&rft_id=info%3Apmid%2F21705501&rft.aulast=Walz&rft.aufirst=C&rft.au=Erben%2C+P&rft.au=Ritter%2C+M&rft.au=Bloor%2C+A&rft.au=Metzgeroth%2C+G&rft.au=Telford%2C+N&rft.au=Haferlach%2C+C&rft.au=Haferlach%2C+T&rft.au=Gesk%2C+S&rft.au=Score%2C+J&rft.au=Hofmann%2C+WK&rft.au=Hochhaus%2C+A&rft.au=Cross%2C+NC&rft.au=Reiter%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2011-03-343426&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid27839918-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27839918_30-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLamArikawaCramlettDong2016" class="citation journal cs1">Lam B, Arikawa Y, Cramlett J, Dong Q, de Jong R, Feher V, Grimshaw CE, Farrell PJ, Hoffman ID, Jennings A, Jones B, Matuszkiewicz J, Miura J, Miyake H, Natala SR, Shi L, Takahashi M, Taylor E, Wyrick C, Yano J, Zalevsky J, Nie Z (December 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bmcl.2016.10.087">"Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)"</a>. <i>Bioorganic & Medicinal Chemistry Letters</i>. <b>26</b> (24): 5947–5950. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bmcl.2016.10.087">10.1016/j.bmcl.2016.10.087</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27839918">27839918</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bioorganic+%26+Medicinal+Chemistry+Letters&rft.atitle=Discovery+of+TAK-659+an+orally+available+investigational+inhibitor+of+Spleen+Tyrosine+Kinase+%28SYK%29&rft.volume=26&rft.issue=24&rft.pages=5947-5950&rft.date=2016-12&rft_id=info%3Adoi%2F10.1016%2Fj.bmcl.2016.10.087&rft_id=info%3Apmid%2F27839918&rft.aulast=Lam&rft.aufirst=B&rft.au=Arikawa%2C+Y&rft.au=Cramlett%2C+J&rft.au=Dong%2C+Q&rft.au=de+Jong%2C+R&rft.au=Feher%2C+V&rft.au=Grimshaw%2C+CE&rft.au=Farrell%2C+PJ&rft.au=Hoffman%2C+ID&rft.au=Jennings%2C+A&rft.au=Jones%2C+B&rft.au=Matuszkiewicz%2C+J&rft.au=Miura%2C+J&rft.au=Miyake%2C+H&rft.au=Natala%2C+SR&rft.au=Shi%2C+L&rft.au=Takahashi%2C+M&rft.au=Taylor%2C+E&rft.au=Wyrick%2C+C&rft.au=Yano%2C+J&rft.au=Zalevsky%2C+J&rft.au=Nie%2C+Z&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.bmcl.2016.10.087&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid24319172-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid24319172_31-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarrison2013" class="citation journal cs1">Harrison CJ (2013). <a rel="nofollow" class="external text" href="http://asheducationbook.hematologylibrary.org/content/2013/1/118.full.pdf">"Targeting signaling pathways in acute lymphoblastic leukemia: new insights"</a> <span class="cs1-format">(PDF)</span>. <i>Hematology. American Society of Hematology. Education Program</i>. <b>2013</b>: 118–25. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fasheducation-2013.1.118">10.1182/asheducation-2013.1.118</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24319172">24319172</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24762855">24762855</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Hematology.+American+Society+of+Hematology.+Education+Program&rft.atitle=Targeting+signaling+pathways+in+acute+lymphoblastic+leukemia%3A+new+insights&rft.volume=2013&rft.pages=118-25&rft.date=2013&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24762855%23id-name%3DS2CID&rft_id=info%3Apmid%2F24319172&rft_id=info%3Adoi%2F10.1182%2Fasheducation-2013.1.118&rft.aulast=Harrison&rft.aufirst=CJ&rft_id=http%3A%2F%2Fasheducationbook.hematologylibrary.org%2Fcontent%2F2013%2F1%2F118.full.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid24066765-32"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid24066765_32-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid24066765_32-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid24066765_32-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKarGutierrez-Hartmann2013" class="citation journal cs1">Kar A, Gutierrez-Hartmann A (2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086824">"Molecular mechanisms of ETS transcription factor-mediated tumorigenesis"</a>. <i>Critical Reviews in Biochemistry and Molecular Biology</i>. <b>48</b> (6): 522–43. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F10409238.2013.838202">10.3109/10409238.2013.838202</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086824">4086824</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24066765">24066765</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Biochemistry+and+Molecular+Biology&rft.atitle=Molecular+mechanisms+of+ETS+transcription+factor-mediated+tumorigenesis&rft.volume=48&rft.issue=6&rft.pages=522-43&rft.date=2013&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4086824%23id-name%3DPMC&rft_id=info%3Apmid%2F24066765&rft_id=info%3Adoi%2F10.3109%2F10409238.2013.838202&rft.aulast=Kar&rft.aufirst=A&rft.au=Gutierrez-Hartmann%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4086824&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid12450792-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12450792_33-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTognonKnezevichHuntsmanRoskelley2002" class="citation journal cs1">Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PH (November 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1535-6108%2802%2900180-0">"Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma"</a>. <i>Cancer Cell</i>. <b>2</b> (5): 367–76. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1535-6108%2802%2900180-0">10.1016/S1535-6108(02)00180-0</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12450792">12450792</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Cell&rft.atitle=Expression+of+the+ETV6-NTRK3+gene+fusion+as+a+primary+event+in+human+secretory+breast+carcinoma&rft.volume=2&rft.issue=5&rft.pages=367-76&rft.date=2002-11&rft_id=info%3Adoi%2F10.1016%2FS1535-6108%2802%2900180-0&rft_id=info%3Apmid%2F12450792&rft.aulast=Tognon&rft.aufirst=C&rft.au=Knezevich%2C+SR&rft.au=Huntsman%2C+D&rft.au=Roskelley%2C+CD&rft.au=Melnyk%2C+N&rft.au=Mathers%2C+JA&rft.au=Becker%2C+L&rft.au=Carneiro%2C+F&rft.au=MacPherson%2C+N&rft.au=Horsman%2C+D&rft.au=Poremba%2C+C&rft.au=Sorensen%2C+PH&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1535-6108%252802%252900180-0&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-34">^</a></b></span> <span class="reference-text">Majewska H, Skálová A, Stodulski D, Klimková A, Steiner P, Stankiewicz C, Biernat W. "Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement." Virchows Arch. 2015 Mar;466(3):245-54. doi: 10.1007/s00428-014-1701-8. Epub 2014 Dec 12.</span> </li> <li id="cite_note-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-35">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArganiFritschKadkolSchuster2000" class="citation journal cs1">Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB, Perlman EJ (January 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.3880006">"Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors"</a>. <i>Modern Pathology</i>. <b>13</b> (1): 29–36. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.3880006">10.1038/modpathol.3880006</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10658907">10658907</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Modern+Pathology&rft.atitle=Detection+of+the+ETV6-NTRK3+chimeric+RNA+of+infantile+fibrosarcoma%2Fcellular+congenital+mesoblastic+nephroma+in+paraffin-embedded+tissue%3A+application+to+challenging+pediatric+renal+stromal+tumors&rft.volume=13&rft.issue=1&rft.pages=29-36&rft.date=2000-01&rft_id=info%3Adoi%2F10.1038%2Fmodpathol.3880006&rft_id=info%3Apmid%2F10658907&rft.aulast=Argani&rft.aufirst=P&rft.au=Fritsch%2C+M&rft.au=Kadkol%2C+SS&rft.au=Schuster%2C+A&rft.au=Beckwith%2C+JB&rft.au=Perlman%2C+EJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fmodpathol.3880006&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid28060365-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid28060365_36-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSkalovaMichalSimpson2017" class="citation journal cs1">Skalova A, Michal M, Simpson RH (January 2017). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2016.167">"Newly described salivary gland tumors"</a>. <i>Modern Pathology</i>. <b>30</b> (s1): S27–S43. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2016.167">10.1038/modpathol.2016.167</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28060365">28060365</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Modern+Pathology&rft.atitle=Newly+described+salivary+gland+tumors&rft.volume=30&rft.issue=s1&rft.pages=S27-S43&rft.date=2017-01&rft_id=info%3Adoi%2F10.1038%2Fmodpathol.2016.167&rft_id=info%3Apmid%2F28060365&rft.aulast=Skalova&rft.aufirst=A&rft.au=Michal%2C+M&rft.au=Simpson%2C+RH&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fmodpathol.2016.167&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-pmid27259007-37"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27259007_37-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAlassiriAliShenLum2016" class="citation journal cs1">Alassiri AH, Ali RH, Shen Y, Lum A, Strahlendorf C, Deyell R, Rassekh R, Sorensen PH, Laskin J, Marra M, Yip S, Lee CH, Ng TL (August 2016). "ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors". <i>The American Journal of Surgical Pathology</i>. <b>40</b> (8): 1051–61. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FPAS.0000000000000677">10.1097/PAS.0000000000000677</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27259007">27259007</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25165398">25165398</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Surgical+Pathology&rft.atitle=ETV6-NTRK3+Is+Expressed+in+a+Subset+of+ALK-Negative+Inflammatory+Myofibroblastic+Tumors&rft.volume=40&rft.issue=8&rft.pages=1051-61&rft.date=2016-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25165398%23id-name%3DS2CID&rft_id=info%3Apmid%2F27259007&rft_id=info%3Adoi%2F10.1097%2FPAS.0000000000000677&rft.aulast=Alassiri&rft.aufirst=AH&rft.au=Ali%2C+RH&rft.au=Shen%2C+Y&rft.au=Lum%2C+A&rft.au=Strahlendorf%2C+C&rft.au=Deyell%2C+R&rft.au=Rassekh%2C+R&rft.au=Sorensen%2C+PH&rft.au=Laskin%2C+J&rft.au=Marra%2C+M&rft.au=Yip%2C+S&rft.au=Lee%2C+CH&rft.au=Ng%2C+TL&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> <li id="cite_note-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-38">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/results?term=ETV6-NTRK3&Search=Search">"Search for ETV6-NTRK"</a>. <i>ClinicalTrials.gov</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinicalTrials.gov&rft.atitle=Search+for+ETV6-NTRK&rft_id=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fresults%3Fterm%3DETV6-NTRK3%26Search%3DSearch&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=13" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKeungBeatyStewardJackle2002" class="citation journal cs1">Keung YK, Beaty M, Steward W, Jackle B, Pettnati M (October 2002). "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature". <i>Cancer Genetics and Cytogenetics</i>. <b>138</b> (2): 139–42. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0165-4608%2802%2900609-X">10.1016/S0165-4608(02)00609-X</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12505259">12505259</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Genetics+and+Cytogenetics&rft.atitle=Chronic+myelocytic+leukemia+with+eosinophilia%2C+t%289%3B12%29%28q34%3Bp13%29%2C+and+ETV6-ABL+gene+rearrangement%3A+case+report+and+review+of+the+literature&rft.volume=138&rft.issue=2&rft.pages=139-42&rft.date=2002-10&rft_id=info%3Adoi%2F10.1016%2FS0165-4608%2802%2900609-X&rft_id=info%3Apmid%2F12505259&rft.aulast=Keung&rft.aufirst=YK&rft.au=Beaty%2C+M&rft.au=Steward%2C+W&rft.au=Jackle%2C+B&rft.au=Pettnati%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFainsteinEinatGokkelMarcelle1989" class="citation journal cs1">Fainstein E, Einat M, Gokkel E, Marcelle C, Croce CM, Gale RP, Canaani E (December 1989). "Nucleotide sequence analysis of human abl and bcr-abl cDNAs". <i>Oncogene</i>. <b>4</b> (12): 1477–81. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2687768">2687768</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Nucleotide+sequence+analysis+of+human+abl+and+bcr-abl+cDNAs&rft.volume=4&rft.issue=12&rft.pages=1477-81&rft.date=1989-12&rft_id=info%3Apmid%2F2687768&rft.aulast=Fainstein&rft.aufirst=E&rft.au=Einat%2C+M&rft.au=Gokkel%2C+E&rft.au=Marcelle%2C+C&rft.au=Croce%2C+CM&rft.au=Gale%2C+RP&rft.au=Canaani%2C+E&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBuijsSherrvan_Baalvan_Bezouw1995" class="citation journal cs1">Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". <i>Oncogene</i>. <b>10</b> (8): 1511–9. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7731705">7731705</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Translocation+%2812%3B22%29+%28p13%3Bq11%29+in+myeloproliferative+disorders+results+in+fusion+of+the+ETS-like+TEL+gene+on+12p13+to+the+MN1+gene+on+22q11&rft.volume=10&rft.issue=8&rft.pages=1511-9&rft.date=1995-04&rft_id=info%3Apmid%2F7731705&rft.aulast=Buijs&rft.aufirst=A&rft.au=Sherr%2C+S&rft.au=van+Baal%2C+S&rft.au=van+Bezouw%2C+S&rft.au=van+der+Plas%2C+D&rft.au=Geurts+van+Kessel%2C+A&rft.au=Riegman%2C+P&rft.au=Lekanne+Deprez%2C+R&rft.au=Zwarthoff%2C+E&rft.au=Hagemeijer%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGolubBarkerBohlanderHiebert1995" class="citation journal cs1">Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG (May 1995). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41818">"Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>92</b> (11): 4917–21. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995PNAS...92.4917G">1995PNAS...92.4917G</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.92.11.4917">10.1073/pnas.92.11.4917</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41818">41818</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7761424">7761424</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Fusion+of+the+TEL+gene+on+12p13+to+the+AML1+gene+on+21q22+in+acute+lymphoblastic+leukemia&rft.volume=92&rft.issue=11&rft.pages=4917-21&rft.date=1995-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC41818%23id-name%3DPMC&rft_id=info%3Apmid%2F7761424&rft_id=info%3Adoi%2F10.1073%2Fpnas.92.11.4917&rft_id=info%3Abibcode%2F1995PNAS...92.4917G&rft.aulast=Golub&rft.aufirst=TR&rft.au=Barker%2C+GF&rft.au=Bohlander%2C+SK&rft.au=Hiebert%2C+SW&rft.au=Ward%2C+DC&rft.au=Bray-Ward%2C+P&rft.au=Morgan%2C+E&rft.au=Raimondi%2C+SC&rft.au=Rowley%2C+JD&rft.au=Gilliland%2C+DG&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC41818&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRomanaMauchaufféLe_ConiatChumakov1995" class="citation journal cs1">Romana SP, Mauchauffé M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA (June 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V85.12.3662.bloodjournal85123662">"The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion"</a>. <i>Blood</i>. <b>85</b> (12): 3662–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V85.12.3662.bloodjournal85123662">10.1182/blood.V85.12.3662.bloodjournal85123662</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7780150">7780150</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=The+t%2812%3B21%29+of+acute+lymphoblastic+leukemia+results+in+a+tel-AML1+gene+fusion&rft.volume=85&rft.issue=12&rft.pages=3662-70&rft.date=1995-06&rft_id=info%3Adoi%2F10.1182%2Fblood.V85.12.3662.bloodjournal85123662&rft_id=info%3Apmid%2F7780150&rft.aulast=Romana&rft.aufirst=SP&rft.au=Mauchauff%C3%A9%2C+M&rft.au=Le+Coniat%2C+M&rft.au=Chumakov%2C+I&rft.au=Le+Paslier%2C+D&rft.au=Berger%2C+R&rft.au=Bernard%2C+OA&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood.V85.12.3662.bloodjournal85123662&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPapadopoulosRidgeBoucherStocking1995" class="citation journal cs1">Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM (January 1995). "The novel activation of ABL by fusion to an ets-related gene, TEL". <i>Cancer Research</i>. <b>55</b> (1): 34–8. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7805037">7805037</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=The+novel+activation+of+ABL+by+fusion+to+an+ets-related+gene%2C+TEL&rft.volume=55&rft.issue=1&rft.pages=34-8&rft.date=1995-01&rft_id=info%3Apmid%2F7805037&rft.aulast=Papadopoulos&rft.aufirst=P&rft.au=Ridge%2C+SA&rft.au=Boucher%2C+CA&rft.au=Stocking%2C+C&rft.au=Wiedemann%2C+LM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGolubBarkerLovettGilliland1994" class="citation journal cs1">Golub TR, Barker GF, Lovett M, Gilliland DG (April 1994). "Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation". <i>Cell</i>. <b>77</b> (2): 307–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2894%2990322-0">10.1016/0092-8674(94)90322-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8168137">8168137</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:30073372">30073372</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Fusion+of+PDGF+receptor+beta+to+a+novel+ets-like+gene%2C+tel%2C+in+chronic+myelomonocytic+leukemia+with+t%285%3B12%29+chromosomal+translocation&rft.volume=77&rft.issue=2&rft.pages=307-16&rft.date=1994-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A30073372%23id-name%3DS2CID&rft_id=info%3Apmid%2F8168137&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2894%2990322-0&rft.aulast=Golub&rft.aufirst=TR&rft.au=Barker%2C+GF&rft.au=Lovett%2C+M&rft.au=Gilliland%2C+DG&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWlodarskaBaensPeetersAerssens1996" class="citation journal cs1">Wlodarska I, Baens M, Peeters P, Aerssens J, Mecucci C, Brock P, Marynen P, Van den Berghe H (June 1996). "Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case". <i>Cancer Research</i>. <b>56</b> (11): 2655–61. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8653712">8653712</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Biallelic+alterations+of+both+ETV6+and+CDKN1B+genes+in+a+t%2812%3B21%29+childhood+acute+lymphoblastic+leukemia+case&rft.volume=56&rft.issue=11&rft.pages=2655-61&rft.date=1996-06&rft_id=info%3Apmid%2F8653712&rft.aulast=Wlodarska&rft.aufirst=I&rft.au=Baens%2C+M&rft.au=Peeters%2C+P&rft.au=Aerssens%2C+J&rft.au=Mecucci%2C+C&rft.au=Brock%2C+P&rft.au=Marynen%2C+P&rft.au=Van+den+Berghe%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBaensPeetersGuoAerssens1996" class="citation journal cs1">Baens M, Peeters P, Guo C, Aerssens J, Marynen P (May 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.5.404">"Genomic organization of TEL: the human ETS-variant gene 6"</a>. <i>Genome Research</i>. <b>6</b> (5): 404–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.5.404">10.1101/gr.6.5.404</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8743990">8743990</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Genomic+organization+of+TEL%3A+the+human+ETS-variant+gene+6&rft.volume=6&rft.issue=5&rft.pages=404-13&rft.date=1996-05&rft_id=info%3Adoi%2F10.1101%2Fgr.6.5.404&rft_id=info%3Apmid%2F8743990&rft.aulast=Baens&rft.aufirst=M&rft.au=Peeters%2C+P&rft.au=Guo%2C+C&rft.au=Aerssens%2C+J&rft.au=Marynen%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgr.6.5.404&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBonaldoLennonSoares1996" class="citation journal cs1">Bonaldo MF, Lennon G, Soares MB (September 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">"Normalization and subtraction: two approaches to facilitate gene discovery"</a>. <i>Genome Research</i>. <b>6</b> (9): 791–806. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.791">10.1101/gr.6.9.791</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8889548">8889548</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Normalization+and+subtraction%3A+two+approaches+to+facilitate+gene+discovery&rft.volume=6&rft.issue=9&rft.pages=791-806&rft.date=1996-09&rft_id=info%3Adoi%2F10.1101%2Fgr.6.9.791&rft_id=info%3Apmid%2F8889548&rft.aulast=Bonaldo&rft.aufirst=MF&rft.au=Lennon%2C+G&rft.au=Soares%2C+MB&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgr.6.9.791&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHillierLennonBeckerBonaldo1996" class="citation journal cs1">Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.807">"Generation and analysis of 280,000 human expressed sequence tags"</a>. <i>Genome Research</i>. <b>6</b> (9): 807–28. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.6.9.807">10.1101/gr.6.9.807</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8889549">8889549</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Generation+and+analysis+of+280%2C000+human+expressed+sequence+tags&rft.volume=6&rft.issue=9&rft.pages=807-28&rft.date=1996-09&rft_id=info%3Adoi%2F10.1101%2Fgr.6.9.807&rft_id=info%3Apmid%2F8889549&rft.aulast=Hillier&rft.aufirst=LD&rft.au=Lennon%2C+G&rft.au=Becker%2C+M&rft.au=Bonaldo%2C+MF&rft.au=Chiapelli%2C+B&rft.au=Chissoe%2C+S&rft.au=Dietrich%2C+N&rft.au=DuBuque%2C+T&rft.au=Favello%2C+A&rft.au=Gish%2C+W&rft.au=Hawkins%2C+M&rft.au=Hultman%2C+M&rft.au=Kucaba%2C+T&rft.au=Lacy%2C+M&rft.au=Le%2C+M&rft.au=Le%2C+N&rft.au=Mardis%2C+E&rft.au=Moore%2C+B&rft.au=Morris%2C+M&rft.au=Parsons%2C+J&rft.au=Prange%2C+C&rft.au=Rifkin%2C+L&rft.au=Rohlfing%2C+T&rft.au=Schellenberg%2C+K&rft.au=Bento+Soares%2C+M&rft.au=Tan%2C+F&rft.au=Thierry-Meg%2C+J&rft.au=Trevaskis%2C+E&rft.au=Underwood%2C+K&rft.au=Wohldman%2C+P&rft.au=Waterston%2C+R&rft.au=Wilson%2C+R&rft.au=Marra%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgr.6.9.807&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAndreassonJohanssonArhedenBillström1997" class="citation journal cs1">Andreasson P, Johansson B, Arheden K, Billström R, Mitelman F, Höglund M (June 1997). "Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities". <i>Genes, Chromosomes & Cancer</i>. <b>19</b> (2): 77–83. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291098-2264%28199706%2919%3A2%3C77%3A%3AAID-GCC2%3E3.0.CO%3B2-X">10.1002/(SICI)1098-2264(199706)19:2<77::AID-GCC2>3.0.CO;2-X</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9171997">9171997</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27083284">27083284</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes%2C+Chromosomes+%26+Cancer&rft.atitle=Deletions+of+CDKN1B+and+ETV6+in+acute+myeloid+leukemia+and+myelodysplastic+syndromes+without+cytogenetic+evidence+of+12p+abnormalities&rft.volume=19&rft.issue=2&rft.pages=77-83&rft.date=1997-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A27083284%23id-name%3DS2CID&rft_id=info%3Apmid%2F9171997&rft_id=info%3Adoi%2F10.1002%2F%28SICI%291098-2264%28199706%2919%3A2%3C77%3A%3AAID-GCC2%3E3.0.CO%3B2-X&rft.aulast=Andreasson&rft.aufirst=P&rft.au=Johansson%2C+B&rft.au=Arheden%2C+K&rft.au=Billstr%C3%B6m%2C+R&rft.au=Mitelman%2C+F&rft.au=H%C3%B6glund%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLacroniqueBoureuxVallePoirel1997" class="citation journal cs1">Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffé M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA (November 1997). "A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia". <i>Science</i>. <b>278</b> (5341): 1309–12. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1997Sci...278.1309L">1997Sci...278.1309L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.278.5341.1309">10.1126/science.278.5341.1309</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9360930">9360930</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=A+TEL-JAK2+fusion+protein+with+constitutive+kinase+activity+in+human+leukemia&rft.volume=278&rft.issue=5341&rft.pages=1309-12&rft.date=1997-11&rft_id=info%3Apmid%2F9360930&rft_id=info%3Adoi%2F10.1126%2Fscience.278.5341.1309&rft_id=info%3Abibcode%2F1997Sci...278.1309L&rft.aulast=Lacronique&rft.aufirst=V&rft.au=Boureux%2C+A&rft.au=Valle%2C+VD&rft.au=Poirel%2C+H&rft.au=Quang%2C+CT&rft.au=Mauchauff%C3%A9%2C+M&rft.au=Berthou%2C+C&rft.au=Lessard%2C+M&rft.au=Berger%2C+R&rft.au=Ghysdael%2C+J&rft.au=Bernard%2C+OA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKnezevichMcFaddenTaoLim1998" class="citation journal cs1">Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (February 1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". <i>Nature Genetics</i>. <b>18</b> (2): 184–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng0298-184">10.1038/ng0298-184</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9462753">9462753</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7390311">7390311</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=A+novel+ETV6-NTRK3+gene+fusion+in+congenital+fibrosarcoma&rft.volume=18&rft.issue=2&rft.pages=184-7&rft.date=1998-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7390311%23id-name%3DS2CID&rft_id=info%3Apmid%2F9462753&rft_id=info%3Adoi%2F10.1038%2Fng0298-184&rft.aulast=Knezevich&rft.aufirst=SR&rft.au=McFadden%2C+DE&rft.au=Tao%2C+W&rft.au=Lim%2C+JF&rft.au=Sorensen%2C+PH&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKwiatkowskiBastianBauerTsai1998" class="citation journal cs1">Kwiatkowski BA, Bastian LS, Bauer TR, Tsai S, Zielinska-Kwiatkowska AG, Hickstein DD (July 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.28.17525">"The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity"</a>. <i>The Journal of Biological Chemistry</i>. <b>273</b> (28): 17525–30. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.28.17525">10.1074/jbc.273.28.17525</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9651344">9651344</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+ets+family+member+Tel+binds+to+the+Fli-1+oncoprotein+and+inhibits+its+transcriptional+activity&rft.volume=273&rft.issue=28&rft.pages=17525-30&rft.date=1998-07&rft_id=info%3Adoi%2F10.1074%2Fjbc.273.28.17525&rft_id=info%3Apmid%2F9651344&rft.aulast=Kwiatkowski&rft.aufirst=BA&rft.au=Bastian%2C+LS&rft.au=Bauer%2C+TR&rft.au=Tsai%2C+S&rft.au=Zielinska-Kwiatkowska%2C+AG&rft.au=Hickstein%2C+DD&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.273.28.17525&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHannemannMcManusKabarowskiWiedemann1998" class="citation journal cs1">Hannemann JR, McManus DM, Kabarowski JH, Wiedemann LM (July 1998). "Haemopoietic transformation by the TEL/ABL oncogene". <i>British Journal of Haematology</i>. <b>102</b> (2): 475–85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1365-2141.1998.00803.x">10.1046/j.1365-2141.1998.00803.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9695962">9695962</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25904172">25904172</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Haemopoietic+transformation+by+the+TEL%2FABL+oncogene&rft.volume=102&rft.issue=2&rft.pages=475-85&rft.date=1998-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25904172%23id-name%3DS2CID&rft_id=info%3Apmid%2F9695962&rft_id=info%3Adoi%2F10.1046%2Fj.1365-2141.1998.00803.x&rft.aulast=Hannemann&rft.aufirst=JR&rft.au=McManus%2C+DM&rft.au=Kabarowski%2C+JH&rft.au=Wiedemann%2C+LM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChakrabartiSoodGangulyBohlander1999" class="citation journal cs1">Chakrabarti SR, Sood R, Ganguly S, Bohlander S, Shen Z, Nucifora G (June 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22109">"Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>96</b> (13): 7467–72. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1999PNAS...96.7467R">1999PNAS...96.7467R</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.96.13.7467">10.1073/pnas.96.13.7467</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22109">22109</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10377438">10377438</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Modulation+of+TEL+transcription+activity+by+interaction+with+the+ubiquitin-conjugating+enzyme+UBC9&rft.volume=96&rft.issue=13&rft.pages=7467-72&rft.date=1999-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC22109%23id-name%3DPMC&rft_id=info%3Apmid%2F10377438&rft_id=info%3Adoi%2F10.1073%2Fpnas.96.13.7467&rft_id=info%3Abibcode%2F1999PNAS...96.7467R&rft.aulast=Chakrabarti&rft.aufirst=SR&rft.au=Sood%2C+R&rft.au=Ganguly%2C+S&rft.au=Bohlander%2C+S&rft.au=Shen%2C+Z&rft.au=Nucifora%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC22109&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCoolsBilhou-NaberaWlodarskaCabrol1999" class="citation journal cs1">Cools J, Bilhou-Nabera C, Wlodarska I, Cabrol C, Talmant P, Bernard P, Hagemeijer A, Marynen P (September 1999). "Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13)". <i>Blood</i>. <b>94</b> (5): 1820–4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V94.5.1820">10.1182/blood.V94.5.1820</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10477709">10477709</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Fusion+of+a+novel+gene%2C+BTL%2C+to+ETV6+in+acute+myeloid+leukemias+with+a+t%284%3B12%29%28q11-q12%3Bp13%29&rft.volume=94&rft.issue=5&rft.pages=1820-4&rft.date=1999-09&rft_id=info%3Adoi%2F10.1182%2Fblood.V94.5.1820&rft_id=info%3Apmid%2F10477709&rft.aulast=Cools&rft.aufirst=J&rft.au=Bilhou-Nabera%2C+C&rft.au=Wlodarska%2C+I&rft.au=Cabrol%2C+C&rft.au=Talmant%2C+P&rft.au=Bernard%2C+P&rft.au=Hagemeijer%2C+A&rft.au=Marynen%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYagasakiJinnaiYoshidaYokoyama1999" class="citation journal cs1">Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291098-2264%28199911%2926%3A3%3C192%3A%3AAID-GCC2%3E3.0.CO%3B2-E">"Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)"</a>. <i>Genes, Chromosomes & Cancer</i>. <b>26</b> (3): 192–202. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291098-2264%28199911%2926%3A3%3C192%3A%3AAID-GCC2%3E3.0.CO%3B2-E">10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10502316">10502316</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes%2C+Chromosomes+%26+Cancer&rft.atitle=Fusion+of+TEL%2FETV6+to+a+novel+ACS2+in+myelodysplastic+syndrome+and+acute+myelogenous+leukemia+with+t%285%3B12%29%28q31%3Bp13%29&rft.volume=26&rft.issue=3&rft.pages=192-202&rft.date=1999-11&rft_id=info%3Adoi%2F10.1002%2F%28SICI%291098-2264%28199911%2926%3A3%3C192%3A%3AAID-GCC2%3E3.0.CO%3B2-E&rft_id=info%3Apmid%2F10502316&rft.aulast=Yagasaki&rft.aufirst=F&rft.au=Jinnai%2C+I&rft.au=Yoshida%2C+S&rft.au=Yokoyama%2C+Y&rft.au=Matsuda%2C+A&rft.au=Kusumoto%2C+S&rft.au=Kobayashi%2C+H&rft.au=Terasaki%2C+H&rft.au=Ohyashiki%2C+K&rft.au=Asou%2C+N&rft.au=Murohashi%2C+I&rft.au=Bessho%2C+M&rft.au=Hirashima%2C+K&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252F%2528SICI%25291098-2264%2528199911%252926%253A3%253C192%253A%253AAID-GCC2%253E3.0.CO%253B2-E&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWaiKnezevichLucasJansen2000" class="citation journal cs1">Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH (February 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1203396">"The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells"</a>. <i>Oncogene</i>. <b>19</b> (7): 906–15. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1203396">10.1038/sj.onc.1203396</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10702799">10702799</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+ETV6-NTRK3+gene+fusion+encodes+a+chimeric+protein+tyrosine+kinase+that+transforms+NIH3T3+cells&rft.volume=19&rft.issue=7&rft.pages=906-15&rft.date=2000-02&rft_id=info%3Adoi%2F10.1038%2Fsj.onc.1203396&rft_id=info%3Apmid%2F10702799&rft.aulast=Wai&rft.aufirst=DH&rft.au=Knezevich%2C+SR&rft.au=Lucas%2C+T&rft.au=Jansen%2C+B&rft.au=Kay%2C+RJ&rft.au=Sorensen%2C+PH&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.onc.1203396&rfr_id=info%3Asid%2Fen.wikipedia.org%3AETV6" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ETV6&action=edit&section=14" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=ETV6+protein%2C+human">ETV6+protein,+human</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="http://www.sdbonline.org/fly/neural/yan.htm"><i>Drosophila</i> <i>anterior open</i> - The Interactive Fly</a></li></ul> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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SAM Polymer" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/PDB_1ji7_EBI.jpg/180px-PDB_1ji7_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/PDB_1ji7_EBI.jpg/270px-PDB_1ji7_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/aa/PDB_1ji7_EBI.jpg/360px-PDB_1ji7_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ji7</b>: Crystal Structure of TEL SAM Polymer</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lky_EBI.jpg" class="mw-file-description" title="1lky: Structure of the wild-type TEL-SAM polymer"><img alt="1lky: Structure of the wild-type TEL-SAM polymer" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1lky_EBI.jpg/180px-PDB_1lky_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1lky_EBI.jpg/270px-PDB_1lky_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1lky_EBI.jpg/360px-PDB_1lky_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lky</b>: Structure of the wild-type TEL-SAM polymer</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2dao_EBI.png" class="mw-file-description" title="2dao: Solution structure of ETS domain Transcriptional factor ETV6 protein"><img alt="2dao: Solution structure of ETS domain Transcriptional factor ETV6 protein" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_2dao_EBI.png/180px-PDB_2dao_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_2dao_EBI.png/270px-PDB_2dao_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_2dao_EBI.png/360px-PDB_2dao_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2dao</b>: Solution structure of ETS domain Transcriptional factor ETV6 protein</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Transcription_factors_and_intracellular_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Transcription_factors_and_intracellular_receptors" title="Template:Transcription factors and intracellular receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Transcription_factors_and_intracellular_receptors" title="Template talk:Transcription factors and intracellular receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Transcription_factors_and_intracellular_receptors" title="Special:EditPage/Template:Transcription factors and intracellular receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_factors_and_intracellular_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="/wiki/Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li><i>BACH</i> <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li> <li><i>NFE</i> <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li><i>NRF</i> <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li><i>HAND</i> <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li><i>OLIG</i> <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li><i>Paraxis</i> <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li><i>SLC</i> <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li><i>TAL</i> <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br />bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li><i>PER</i> <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li><i>SIM</i> <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>BHLH</i> <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li><i>ID</i> <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>HES</i> <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li><i>HEY</i> <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br />bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>RFX</i> <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li><i>MTA</i> <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><i><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li><i>GLI family</i> <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li><i>HIC</i> <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li><i>HIVEP</i> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li><i>IKZF</i> <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li><i>ILF</i> <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li><i>KLF</i> <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li><i>SP</i> <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li><i>SALL</i> <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li><i>ZBTB</i> <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li><i>zinc finger</i> <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><i>ING</i> <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li><i>JARID</i> <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br /><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br /><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br /><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li><i>DBX</i> <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><i><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a></i> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li><i>EN</i> <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li><i>MSX</i> <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/NATO" title="NATO">NATO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li><i>FHL</i> <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li><i>LMX</i> <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a href="/wiki/NOBOX" title="NOBOX">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li><i>MEIS</i> <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li><i>PBX</i> <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li><i>PKNOX</i> <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li><i>SIX</i> <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li><i>PHF</i> <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li><i>ZEB</i> <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li><i>PHOX</i> <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li><i>OTX</i> <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li><i>PITX</i> <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a></i> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>ELF</i> <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EGF</a></li> <li><i>ELK</i> <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li><i>ETV</i> <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a class="mw-selflink selflink">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>transcriptional enhancer factor</i> <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a href="/wiki/RELA" title="RELA">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a href="/wiki/STAT1" title="STAT1">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li><i>HNF</i> <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li><i>TCF</i> <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li><i>TOX</i> <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARID</i> <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li><i>IFI</i> <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li><i>NFY</i> <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: 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