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class="vector-toc-numb">2</span> <span>Gene location</span> </div> </a> <ul id="toc-Gene_location-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Protein_structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Protein_structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Protein structure</span> </div> </a> <ul id="toc-Protein_structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mutations_and_clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mutations_and_clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Mutations and clinical significance</span> </div> </a> <ul id="toc-Mutations_and_clinical_significance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">NOBOX</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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Arabic" lang="arz" hreflang="arz" data-title="NOBOX" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/NOBOX" title="NOBOX – Tatar" lang="tt" hreflang="tt" data-title="NOBOX" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/NOBOX" title="NOBOX – Ukrainian" lang="uk" hreflang="uk" data-title="NOBOX" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18050649#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/NOBOX" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:NOBOX" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" 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class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/NOBOX" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/NOBOX" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=NOBOX&oldid=1216107995" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=NOBOX&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=NOBOX&id=1216107995&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FNOBOX"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FNOBOX"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=NOBOX&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=NOBOX&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18050649" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">NOBOX</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/22448">NOBOX</a></span>, OG-2, OG2, OG2X, POF5, TCAG_12042, NOBOX oogenesis homeobox</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/610934">610934</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:108011">108011</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=51066">51066</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=NOBOX">NOBOX</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000106410">NOBOX - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/450px-Ideogram_human_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/600px-Ideogram_human_chromosome_7.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_7_(human)" class="mw-redirect" title="Chromosome 7 (human)">Chromosome 7 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_7_ideogram.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/300px-Human_chromosome_7_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/450px-Human_chromosome_7_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/600px-Human_chromosome_7_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 261.15165126954px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for NOBOX"><img alt="Genomic location for NOBOX" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 267.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for NOBOX"><img alt="Genomic location for NOBOX" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">7q35</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">144,397,240 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">144,410,227 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (mouse)"><img alt="Chromosome 6 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/260px-Ideogram_house_mouse_chromosome_6.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/390px-Ideogram_house_mouse_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/520px-Ideogram_house_mouse_chromosome_6.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 6 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (mouse)"><img alt="Chromosome 6 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/300px-Ideogram_of_house_mouse_chromosome_6.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/450px-Ideogram_of_house_mouse_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_6.svg/600px-Ideogram_of_house_mouse_chromosome_6.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 79.623521783343px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for NOBOX"><img alt="Genomic location for NOBOX" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 85.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for NOBOX"><img alt="Genomic location for NOBOX" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">6 B2.1|6 21.17 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">43,280,608 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">43,286,488 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000106410">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">gonad</li><br /><li style="line-height: 137%;">right testis</li><br /><li style="line-height: 137%;">left testis</li><br /><li style="line-height: 137%;">right ovary</li><br /><li style="line-height: 137%;">left ovary</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000029736">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">primary oocyte</li><br /><li style="line-height: 137%;">zygote</li><br /><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">ovary</li><br /><li style="line-height: 137%;">morula</li><br /><li style="line-height: 137%;">morula</li><br /><li style="line-height: 137%;">lens</li><br /><li style="line-height: 137%;">blastocyst</li><br /><li style="line-height: 137%;">epithelium of lens</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000106410">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007275">multicellular organism development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048477">oogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006357">regulation of transcription by RNA polymerase II</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=135935&rn=1">135935</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=18291&rn=1">18291</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000106410;db=core">ENSG00000106410</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000285328;db=core">ENSG00000285328</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000029736;db=core">ENSMUSG00000029736</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O60393">O60393</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8VIH1">Q8VIH1</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001080413">NM_001080413</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_130869">NM_130869</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001073882">NP_001073882</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_570939">NP_570939</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr7:144397240-144410227">Chr 7: 144.4 – 144.41 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr6:43280608-43286488">Chr 6: 43.28 – 43.29 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18050649" class="extiw" title="d:Q18050649">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18252775" class="extiw" title="d:Q18252775">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Homeobox protein NOBOX</b>, also known as <b>newborn ovary homeobox protein</b>, is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>NOBOX</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11804785_6-0" class="reference"><a href="#cite_note-pmid11804785-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16597639_7-0" class="reference"><a href="#cite_note-pmid16597639-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The official symbol (NOBOX) and the official full name (NOBOX oogenesis homeobox) are maintained by the <a href="/wiki/HGNC" class="mw-redirect" title="HGNC">HGNC</a>. The <i>NOBOX</i> gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat. There are 175 organisms that have <a href="/wiki/Sequence_homology" title="Sequence homology">orthologs</a> with human gene <i>NOBOX.</i> It is capable of regulating other genes that are important in the development of follicles. Follicles do not develop and <a href="/wiki/Oocyte" title="Oocyte">oocytes</a> decrease in its absence which lead to <a href="/wiki/Infertility" title="Infertility">infertility</a>.<sup id="cite_ref-:2_8-0" class="reference"><a href="#cite_note-:2-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Discovery">Discovery</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=1" title="Edit section: Discovery"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>NOBOX is an <i>in silico</i> subtraction discovery when Suzumori <i>et al</i>. searched for novel genes involved in early mammalian <a href="/wiki/Folliculogenesis" title="Folliculogenesis">folliculogenesis</a> in 2002. It is one of the several genes that appeared in the search in expressed sequence tag (EST) databases of mouse.<sup id="cite_ref-pmid11804785_6-1" class="reference"><a href="#cite_note-pmid11804785-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It was then cloned and characterised for its genomic structure. </p> <div class="mw-heading mw-heading2"><h2 id="Gene_location">Gene location</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=2" title="Edit section: Gene location"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The human <i>NOBOX</i> is located in chromosome 7q35 while the mouse <i>NOBOX</i> is in proximal chromosome 6. </p> <div class="mw-heading mw-heading2"><h2 id="Protein_structure">Protein structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=3" title="Edit section: Protein structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The human <i>NOBOX</i> is a 14 kb protein and encoded by 8 exons.<sup id="cite_ref-pmid11804785_6-2" class="reference"><a href="#cite_note-pmid11804785-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It has a proline rich C terminus and contains putative SH3 and WW domains.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> This C terminus is believed to be critical in its transcriptional activities when bound to oocyte-specific genes.<sup id="cite_ref-:0_10-0" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> NOBOX belongs to the family of proteins that contains <a href="/wiki/Homeodomain" class="mw-redirect" title="Homeodomain">homeodomain</a>. Homeodomain is a stretch of 32 specific amino acids in primates downstream the NOBOX Arg303 residue and is very well-conserved among the species.<sup id="cite_ref-:3_11-0" class="reference"><a href="#cite_note-:3-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> It contains an asparagine residue at position 51 which is important for its interactions with DNA base pairs.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=4" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>NOBOX</i> is a <a href="/wiki/Homeobox" title="Homeobox">homeobox</a> gene that is preferentially expressed in oocytes. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes.<sup id="cite_ref-pmid16597639_7-1" class="reference"><a href="#cite_note-pmid16597639-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Regulation of these oocyte-specific genes is thru direct binding of NOBOX to its promoter regions via the specific consensus sequences, the NOBOX DNA binding elements (NBEs). There are three NBEs that have been identified: 5'-TAATTG-3', 5'-TAGTTG-3', and 5'-TAATTA-3'.<sup id="cite_ref-:0_10-1" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Knockout study of <i>NOBOX</i> against wild-type ovaries in newborn female mice revealed that 74% (28/38 genes) were downregulated more than 5-fold and 15% (5/33 genes) were upregulated more than 5-fold.<sup id="cite_ref-:1_15-0" class="reference"><a href="#cite_note-:1-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> However, microRNA population is not affected by <i>NOBOX</i> in newborn ovaries. NOBOX also plays an important role in the suppression of male-determining genes such as <i><a href="/wiki/DMRT1" title="DMRT1">Dmrt1</a></i>.<sup id="cite_ref-:1_15-1" class="reference"><a href="#cite_note-:1-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Its deficiency can cause rapid loss of postnatal oocytes and during its absence in female mice, follicles are replaced by fibrous tissue.<sup id="cite_ref-pmid11804785_6-3" class="reference"><a href="#cite_note-pmid11804785-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Recently, a new role of NOBOX in controlling the <a href="/wiki/G2-M_DNA_damage_checkpoint" title="G2-M DNA damage checkpoint">G2/M</a> arrest was discovered.<sup id="cite_ref-:4_16-0" class="reference"><a href="#cite_note-:4-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mutations_and_clinical_significance">Mutations and clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=5" title="Edit section: Mutations and clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A mutation in the NOBOX gene is associated with <a href="/wiki/Premature_ovarian_failure" class="mw-redirect" title="Premature ovarian failure">premature ovarian failure (POF)</a>, also known as premature ovarian insufficiency (POI).<sup id="cite_ref-pmid17701902_17-0" class="reference"><a href="#cite_note-pmid17701902-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> It is a condition which ovaries loss its normal function before the age of 40. It is a heritable disease in up to 30% of patients which is characterised by secondary infertility, amenorrhea, hypoestrogenism, and elevated <a href="/wiki/Follicle-stimulating_hormone" title="Follicle-stimulating hormone">follicle-stimulating hormone</a> levels in the serum (FSH>40IU/liter).<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_19-0" class="reference"><a href="#cite_note-:5-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> It affects ≈1% of women below 40 years old.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> A study conducted on 96 white women with POF revealed one case of <a href="/wiki/Zygosity" title="Zygosity">heterozygous</a> mutation in the NOBOX homeodomain, p.Arg355His, in one patient.<sup id="cite_ref-pmid17701902_17-1" class="reference"><a href="#cite_note-pmid17701902-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> This mutation was absent in the control population and significantly disrupts the binding of NOBOX to the NBE. Arg355 is critical to DNA binding and is conserved in the homeodomain of the NOBOX from zebrafish to humans. Moreover, its significant negative effect suggests that NOBOX homeodomain may function as a dimer but its rare occurrence suggests a low contribution to POF. Further investigations on POF were conducted on Caucasian, African, Chinese, and Japanese women diagnosed with POF. Several NOBOX loss-of-function mutations were observed in Caucasian and African women accounting to 6.2%, 5.6% and 6.4%.<sup id="cite_ref-:3_11-1" class="reference"><a href="#cite_note-:3-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> These results suggest that <i>NOBOX</i> gene is a strong autosomal candidate for POF and its genetic mechanism involves haploinsufficiency. However, these mutations were not found in Chinese and Japanese women making it a less common explanation for POF in the region.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p>The POF syndrome is a highly heterogenous clinical disorder but a recent study showed the first <a href="/wiki/Zygosity" title="Zygosity">homozygous</a> mutation associated with NOBOX loss-of-function.<sup id="cite_ref-:4_16-1" class="reference"><a href="#cite_note-:4-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> One patient out of 96 population diagnosed with POF in China was found with one novel homozygous truncating variant in the <i>NOBOX</i> gene. This truncated variant caused a defective transcriptional activation of <a href="/wiki/Growth_differentiation_factor-9" title="Growth differentiation factor-9">GDF9</a>, a well-known target of NOBOX, which led to the lost ability of NOBOX to induce <a href="/wiki/G2-M_DNA_damage_checkpoint" title="G2-M DNA damage checkpoint">G2/M</a> arrest. This finding disagrees that mutation is a less common explanation for POF in Asian population. </p><p>Understanding the mutations in NOBOX homeodomain is important to researchers and clinicians to develop diagnostic and therapeutic approaches for POF such as genetic control of mammalian reproductive life-span, regulation of fertility, and generation of mature eggs in the lab.<sup id="cite_ref-:2_8-1" class="reference"><a href="#cite_note-:2-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=6" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ol><li><a href="/wiki/Bone_morphogenetic_protein_15" title="Bone morphogenetic protein 15">GDF9</a><sup id="cite_ref-:0_10-2" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Oct-4" title="Oct-4">POU5F1</a><sup id="cite_ref-pmid11804785_6-4" class="reference"><a href="#cite_note-pmid11804785-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_10-3" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_8-2" class="reference"><a href="#cite_note-:2-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/DNMT1" title="DNMT1">DNMT10</a><sup id="cite_ref-:2_8-3" class="reference"><a href="#cite_note-:2-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">FOXL2</a><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a><sup id="cite_ref-:2_8-4" class="reference"><a href="#cite_note-:2-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/R-spondin_2" title="R-spondin 2">RSPO2</a><sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/DMRT1" title="DMRT1">DMRT1</a><sup id="cite_ref-:5_19-1" class="reference"><a href="#cite_note-:5-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li></ol> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=7" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000106410,">ENSG00000285328 GRCh38: Ensembl release 89: ENSG00000106410, ENSG00000285328</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000029736">GRCm38: Ensembl release 89: ENSMUSG00000029736</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=135935">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D135935&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANOBOX" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=18291">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D18291&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANOBOX" class="Z3988"></span></span> </li> <li id="cite_note-entrez-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-entrez_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" 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href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBouillyVeitiaBinart2014" class="citation journal cs1">Bouilly J, Veitia RA, Binart N (April 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjmcb%2Fmju006">"NOBOX is a key FOXL2 partner involved in ovarian folliculogenesis"</a>. <i>Journal of Molecular Cell Biology</i>. <b>6</b> (2): <span class="nowrap">175–</span>7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjmcb%2Fmju006">10.1093/jmcb/mju006</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24620032">24620032</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:16608843">16608843</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Cell+Biology&rft.atitle=NOBOX+is+a+key+FOXL2+partner+involved+in+ovarian+folliculogenesis&rft.volume=6&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E175-%3C%2Fspan%3E7&rft.date=2014-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A16608843%23id-name%3DS2CID&rft_id=info%3Apmid%2F24620032&rft_id=info%3Adoi%2F10.1093%2Fjmcb%2Fmju006&rft.aulast=Bouilly&rft.aufirst=J&rft.au=Veitia%2C+RA&rft.au=Binart%2C+N&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fjmcb%252Fmju006&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANOBOX" class="Z3988"></span></span> </li> <li id="cite_note-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-27">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite 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class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=NOBOX&action=edit&section=8" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Journal+of+Medical+Genetics&rft.atitle=A+12Mb+deletion+at+7q33-q35+associated+with+autism+spectrum+disorders+and+primary+amenorrhea&rft.volume=51&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E631-%3C%2Fspan%3E8&rft.date=2008&rft_id=info%3Adoi%2F10.1016%2Fj.ejmg.2008.06.010&rft_id=info%3Apmid%2F18675947&rft.aulast=Rossi&rft.aufirst=E&rft.au=Verri%2C+AP&rft.au=Patricelli%2C+MG&rft.au=Destefani%2C+V&rft.au=Ricca%2C+I&rft.au=Vetro%2C+A&rft.au=Ciccone%2C+R&rft.au=Giorda%2C+R&rft.au=Toniolo%2C+D&rft.au=Maraschio%2C+P&rft.au=Zuffardi%2C+O&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANOBOX" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFQinShiZhaoCarson2009" class="citation journal cs1">Qin Y, Shi Y, Zhao Y, Carson SA, Simpson JL, Chen ZJ (April 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.fertnstert.2008.08.020">"Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure"</a>. <i>Fertility and Sterility</i>. <b>91</b> (4 Suppl): <span class="nowrap">1507–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.fertnstert.2008.08.020">10.1016/j.fertnstert.2008.08.020</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18930203">18930203</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Fertility+and+Sterility&rft.atitle=Mutation+analysis+of+NOBOX+homeodomain+in+Chinese+women+with+premature+ovarian+failure&rft.volume=91&rft.issue=4+Suppl&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1507-%3C%2Fspan%3E9&rft.date=2009-04&rft_id=info%3Adoi%2F10.1016%2Fj.fertnstert.2008.08.020&rft_id=info%3Apmid%2F18930203&rft.aulast=Qin&rft.aufirst=Y&rft.au=Shi%2C+Y&rft.au=Zhao%2C+Y&rft.au=Carson%2C+SA&rft.au=Simpson%2C+JL&rft.au=Chen%2C+ZJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.fertnstert.2008.08.020&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANOBOX" class="Z3988"></span></li></ul> </div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Transcription_factors_and_intracellular_receptors" title="Template:Transcription factors and intracellular receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Transcription_factors_and_intracellular_receptors" title="Template talk:Transcription factors and intracellular receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Transcription_factors_and_intracellular_receptors" title="Special:EditPage/Template:Transcription factors and intracellular receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_factors_and_intracellular_receptors178" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="/wiki/Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains178" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li><i>BACH</i> <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/Small_Maf" title="Small Maf">sMaf</a> <ul><li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li></ul></li> <li><i>NFE</i> <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li><i>NRF</i> <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li><i>HAND</i> <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li><i>OLIG</i> <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li><i>Paraxis</i> <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li><i>SLC</i> <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li><i>TAL</i> <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br />bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li><i>PER</i> <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li><i>SIM</i> <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>BHLH</i> <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li><i>ID</i> <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>HES</i> <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li><i>HEY</i> <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br />bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>RFX</i> <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains178" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li><i>MTA</i> <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><i><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li><i>GLI family</i> <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li><i>HIC</i> <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li><i>HIVEP</i> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li><i>IKZF</i> <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li><i>ILF</i> <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li><i>KLF</i> <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li><i>SP</i> <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li><i>SALL</i> <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li><i>ZBTB</i> <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li><i>zinc finger</i> <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><i>ING</i> <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li><i>JARID</i> <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains178" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br /><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br /><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br /><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li><i>DBX</i> <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><i><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a></i> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li><i>EN</i> <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li><i>MSX</i> <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/Notochord_homeobox_(NOTO)_gene" title="Notochord homeobox (NOTO) gene">NOTO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li><i>FHL</i> <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li><i>LMX</i> <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a class="mw-selflink selflink">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li><i>MEIS</i> <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li><i>PBX</i> <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li><i>PKNOX</i> <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li><i>SIX</i> <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li><i>PHF</i> <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li><i>ZEB</i> <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li><i>PHOX</i> <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li><i>OTX</i> <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li><i>PITX</i> <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a></i> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>ELF</i> <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EHF</a></li> <li><i>ELK</i> <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li><i>ETV</i> <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a href="/wiki/ETV6" title="ETV6">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>transcriptional enhancer factor</i> <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts178" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a href="/wiki/RELA" title="RELA">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a href="/wiki/STAT1" title="STAT1">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li><i>HNF</i> <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX17" title="SOX17">17</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li><i>TCF</i> <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li><i>TOX</i> <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors178" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARID</i> <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li><i>IFI</i> <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li><i>NFY</i> <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://auth.wikimedia.org/loginwiki/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=1" alt="" width="1" height="1" style="border: none; position: 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