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Selective serotonin re-uptake inhibitors - วิกิพีเดีย

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href="/w/index.php?title=%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B8%AA%E0%B8%A3%E0%B9%89%E0%B8%B2%E0%B8%87%E0%B8%9A%E0%B8%B1%E0%B8%8D%E0%B8%8A%E0%B8%B5%E0%B8%9C%E0%B8%B9%E0%B9%89%E0%B9%83%E0%B8%8A%E0%B9%89%E0%B9%83%E0%B8%AB%E0%B8%A1%E0%B9%88&amp;returnto=Selective+serotonin+re-uptake+inhibitors" title="แนะนำให้คุณสร้างบัญชีและเข้าสู่ระบบ แต่ไม่บังคับ" class=""><span>สร้างบัญชี</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B8%A5%E0%B9%87%E0%B8%AD%E0%B8%81%E0%B8%AD%E0%B8%B4%E0%B8%99&amp;returnto=Selective+serotonin+re-uptake+inhibitors" title="แนะนำให้คุณเข้าสู่ระบบ แต่ไม่บังคับ [o]" accesskey="o" class=""><span>เข้าสู่ระบบ</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="ตัวเลือกเพิ่มเติม" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="เครื่องมือส่วนตัว" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">เครื่องมือส่วนตัว</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="เมนูผู้ใช้" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&amp;utm_medium=sidebar&amp;utm_campaign=C13_th.wikipedia.org&amp;uselang=th"><span>บริจาคให้วิกิพีเดีย</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B8%AA%E0%B8%A3%E0%B9%89%E0%B8%B2%E0%B8%87%E0%B8%9A%E0%B8%B1%E0%B8%8D%E0%B8%8A%E0%B8%B5%E0%B8%9C%E0%B8%B9%E0%B9%89%E0%B9%83%E0%B8%8A%E0%B9%89%E0%B9%83%E0%B8%AB%E0%B8%A1%E0%B9%88&amp;returnto=Selective+serotonin+re-uptake+inhibitors" title="แนะนำให้คุณสร้างบัญชีและเข้าสู่ระบบ แต่ไม่บังคับ"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>สร้างบัญชี</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B8%A5%E0%B9%87%E0%B8%AD%E0%B8%81%E0%B8%AD%E0%B8%B4%E0%B8%99&amp;returnto=Selective+serotonin+re-uptake+inhibitors" title="แนะนำให้คุณเข้าสู่ระบบ แต่ไม่บังคับ [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>เข้าสู่ระบบ</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> หน้าสำหรับผู้แก้ไขที่ออกจากระบบ <a href="/wiki/%E0%B8%A7%E0%B8%B4%E0%B8%98%E0%B8%B5%E0%B9%83%E0%B8%8A%E0%B9%89:%E0%B8%9A%E0%B8%97%E0%B8%99%E0%B8%B3" aria-label="เรียนรู้เพิ่มเกี่ยวกับการแก้ไข"><span>เรียนรู้เพิ่มเติม</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%80%E0%B8%A3%E0%B8%B7%E0%B9%88%E0%B8%AD%E0%B8%87%E0%B8%97%E0%B8%B5%E0%B9%88%E0%B8%89%E0%B8%B1%E0%B8%99%E0%B9%80%E0%B8%82%E0%B8%B5%E0%B8%A2%E0%B8%99" title="รายการการแก้ไขจากเลขที่อยู่ไอพีนี้ [y]" accesskey="y"><span>ส่วนร่วม</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B8%AB%E0%B8%99%E0%B9%89%E0%B8%B2%E0%B8%9E%E0%B8%B9%E0%B8%94%E0%B8%84%E0%B8%B8%E0%B8%A2%E0%B8%82%E0%B8%AD%E0%B8%87%E0%B8%89%E0%B8%B1%E0%B8%99" title="อภิปรายเกี่ยวกับการแก้ไขจากเลขที่อยู่ไอพีนี้ [n]" accesskey="n"><span>คุย</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"><!-- CentralNotice --></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="ไซต์"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="สารบัญ" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">สารบัญ</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">ย้ายเมนูไปที่แถบด้านข้าง</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">ซ่อน</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">บทนำ</div> </a> </li> <li id="toc-การใช้ในการแพทย์" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#การใช้ในการแพทย์"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>การใช้ในการแพทย์</span> </div> </a> <button aria-controls="toc-การใช้ในการแพทย์-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle การใช้ในการแพทย์ subsection</span> </button> <ul id="toc-การใช้ในการแพทย์-sublist" class="vector-toc-list"> <li id="toc-โรคซึมเศร้า" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#โรคซึมเศร้า"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>โรคซึมเศร้า</span> </div> </a> <ul id="toc-โรคซึมเศร้า-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-โรควิตกกังวลทั่วไป" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#โรควิตกกังวลทั่วไป"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>โรควิตกกังวลทั่วไป</span> </div> </a> <ul id="toc-โรควิตกกังวลทั่วไป-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-โรคย้ำคิดย้ำทำ_(OCD)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#โรคย้ำคิดย้ำทำ_(OCD)"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>โรคย้ำคิดย้ำทำ (OCD)</span> </div> </a> <ul id="toc-โรคย้ำคิดย้ำทำ_(OCD)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-ความผิดปกติในการรับประทาน" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ความผิดปกติในการรับประทาน"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.4</span> <span>ความผิดปกติในการรับประทาน</span> </div> </a> <ul id="toc-ความผิดปกติในการรับประทาน-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-การฟื้นสภาพจากโรคหลอดเลือดสมอง" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#การฟื้นสภาพจากโรคหลอดเลือดสมอง"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.5</span> <span>การฟื้นสภาพจากโรคหลอดเลือดสมอง</span> </div> </a> <ul id="toc-การฟื้นสภาพจากโรคหลอดเลือดสมอง-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-การหลั่งน้ำอสุจิเร็วเกินไป" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#การหลั่งน้ำอสุจิเร็วเกินไป"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.6</span> <span>การหลั่งน้ำอสุจิเร็วเกินไป</span> </div> </a> <ul id="toc-การหลั่งน้ำอสุจิเร็วเกินไป-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-ผลไม่พึงประสงค์" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#ผลไม่พึงประสงค์"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>ผลไม่พึงประสงค์</span> </div> </a> <button aria-controls="toc-ผลไม่พึงประสงค์-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle ผลไม่พึงประสงค์ subsection</span> </button> <ul id="toc-ผลไม่พึงประสงค์-sublist" class="vector-toc-list"> <li id="toc-ความผิดปกติทางเพศ" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ความผิดปกติทางเพศ"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>ความผิดปกติทางเพศ</span> </div> </a> <ul id="toc-ความผิดปกติทางเพศ-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-หัวใจ" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#หัวใจ"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>หัวใจ</span> </div> </a> <ul id="toc-หัวใจ-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-เลือดออก" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#เลือดออก"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>เลือดออก</span> </div> </a> <ul id="toc-เลือดออก-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-อาการหยุดยา_(Discontinuation_syndrome)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#อาการหยุดยา_(Discontinuation_syndrome)"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.4</span> <span>อาการหยุดยา (Discontinuation syndrome)</span> </div> </a> <ul id="toc-อาการหยุดยา_(Discontinuation_syndrome)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-ความเสี่ยงฆ่าตัวตาย" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ความเสี่ยงฆ่าตัวตาย"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.5</span> <span>ความเสี่ยงฆ่าตัวตาย</span> </div> </a> <ul id="toc-ความเสี่ยงฆ่าตัวตาย-sublist" class="vector-toc-list"> <li id="toc-เด็กและวัยรุ่น" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#เด็กและวัยรุ่น"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.5.1</span> <span>เด็กและวัยรุ่น</span> </div> </a> <ul id="toc-เด็กและวัยรุ่น-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-ผู้ใหญ่" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#ผู้ใหญ่"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.5.2</span> <span>ผู้ใหญ่</span> </div> </a> <ul id="toc-ผู้ใหญ่-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-การตั้งครรภ์และการเลี้ยงลูกด้วยนม" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#การตั้งครรภ์และการเลี้ยงลูกด้วยนม"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.6</span> <span>การตั้งครรภ์และการเลี้ยงลูกด้วยนม</span> </div> </a> <ul id="toc-การตั้งครรภ์และการเลี้ยงลูกด้วยนม-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-อาการขาดยาของทารกเกิดใหม่" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#อาการขาดยาของทารกเกิดใหม่"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.7</span> <span>อาการขาดยาของทารกเกิดใหม่</span> </div> </a> <ul id="toc-อาการขาดยาของทารกเกิดใหม่-sublist" class="vector-toc-list"> <li id="toc-ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.7.1</span> <span>ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด</span> </div> </a> <ul id="toc-ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-ผลทางประสาทจิตเวชต่อลูก" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#ผลทางประสาทจิตเวชต่อลูก"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.7.2</span> <span>ผลทางประสาทจิตเวชต่อลูก</span> </div> </a> <ul id="toc-ผลทางประสาทจิตเวชต่อลูก-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-ยาเกินขนาด" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ยาเกินขนาด"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.8</span> <span>ยาเกินขนาด</span> </div> </a> <ul id="toc-ยาเกินขนาด-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น_ๆ" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น_ๆ"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น ๆ</span> </div> </a> <ul id="toc-ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น_ๆ-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-รายการยา" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#รายการยา"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>รายการยา</span> </div> </a> <button aria-controls="toc-รายการยา-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle รายการยา subsection</span> </button> <ul id="toc-รายการยา-sublist" class="vector-toc-list"> <li id="toc-ยาที่เกี่ยวข้องกัน" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ยาที่เกี่ยวข้องกัน"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>ยาที่เกี่ยวข้องกัน</span> </div> </a> <ul id="toc-ยาที่เกี่ยวข้องกัน-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-กลไกการออกฤทธิ์" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#กลไกการออกฤทธิ์"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>กลไกการออกฤทธิ์</span> </div> </a> <button aria-controls="toc-กลไกการออกฤทธิ์-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle กลไกการออกฤทธิ์ subsection</span> </button> <ul id="toc-กลไกการออกฤทธิ์-sublist" class="vector-toc-list"> <li id="toc-เภสัชพันธุศาสตร์" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#เภสัชพันธุศาสตร์"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>เภสัชพันธุศาสตร์</span> </div> </a> <ul id="toc-เภสัชพันธุศาสตร์-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-SSRIs_เทียบกับ_TCAs" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#SSRIs_เทียบกับ_TCAs"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>SSRIs เทียบกับ TCAs</span> </div> </a> <ul id="toc-SSRIs_เทียบกับ_TCAs-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-สังคมและวัฒนธรรม" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#สังคมและวัฒนธรรม"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>สังคมและวัฒนธรรม</span> </div> </a> <button aria-controls="toc-สังคมและวัฒนธรรม-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle สังคมและวัฒนธรรม subsection</span> </button> <ul id="toc-สังคมและวัฒนธรรม-sublist" class="vector-toc-list"> <li id="toc-ข้อขัดแย้ง" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ข้อขัดแย้ง"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>ข้อขัดแย้ง</span> </div> </a> <ul id="toc-ข้อขัดแย้ง-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-เชิงอรรถและอ้างอิง" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#เชิงอรรถและอ้างอิง"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>เชิงอรรถและอ้างอิง</span> </div> </a> <ul id="toc-เชิงอรรถและอ้างอิง-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-แหล่งข้อมูลอื่น" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#แหล่งข้อมูลอื่น"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>แหล่งข้อมูลอื่น</span> </div> </a> <ul id="toc-แหล่งข้อมูลอื่น-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="สารบัญ" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Selective serotonin re-uptake inhibitors</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="ไปที่บทความในภาษาอื่น ซึ่งมีใน 43 ภาษา" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-43" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">43 ภาษา</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%AB%D8%A8%D8%B7%D8%A7%D8%AA_%D8%A7%D8%B3%D8%AA%D8%B1%D8%AF%D8%A7%D8%AF_%D8%A7%D9%84%D8%B3%D9%8A%D8%B1%D9%88%D8%AA%D9%88%D9%86%D9%8A%D9%86_%D8%A7%D9%84%D8%A7%D9%86%D8%AA%D9%82%D8%A7%D8%A6%D9%8A%D8%A9" title="مثبطات استرداد السيروتونين الانتقائية – อาหรับ" lang="ar" hreflang="ar" data-title="مثبطات استرداد السيروتونين الانتقائية" data-language-autonym="العربية" data-language-local-name="อาหรับ" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B8%E0%A6%BF%E0%A6%B2%E0%A7%87%E0%A6%95%E0%A7%8D%E0%A6%9F%E0%A6%BF%E0%A6%AD_%E0%A6%B8%E0%A7%87%E0%A6%B0%E0%A7%8B%E0%A6%9F%E0%A7%8B%E0%A6%A8%E0%A6%BF%E0%A6%A8_%E0%A6%B0%E0%A6%BF%E0%A6%86%E0%A6%AA%E0%A6%9F%E0%A7%87%E0%A6%95_%E0%A6%87%E0%A6%A8%E0%A6%B9%E0%A6%BF%E0%A6%AC%E0%A6%BF%E0%A6%9F%E0%A6%B0" title="সিলেক্টিভ সেরোটোনিন রিআপটেক ইনহিবিটর – บังกลา" lang="bn" hreflang="bn" data-title="সিলেক্টিভ সেরোটোনিন রিআপটেক ইনহিবিটর" data-language-autonym="বাংলা" data-language-local-name="บังกลา" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Inhibidor_selectiu_de_la_recaptaci%C3%B3_de_serotonina" title="Inhibidor selectiu de la recaptació de serotonina – คาตาลัน" lang="ca" hreflang="ca" data-title="Inhibidor selectiu de la recaptació de serotonina" data-language-autonym="Català" data-language-local-name="คาตาลัน" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cdo mw-list-item"><a href="https://cdo.wikipedia.org/wiki/S%C5%8Dng-d%C4%95k-s%C3%A1ng_H%C3%A1ik-ch%C4%ADng-s%C3%B3_C%C3%A1i-si%C3%A9k-ch%E1%B9%B3%CC%84_%C3%89k-ci%C3%A9-c%C3%A2" title="Sōng-dĕk-sáng Háik-chĭng-só Cái-siék-chṳ̄ Ék-cié-câ – Mindong" lang="cdo" hreflang="cdo" data-title="Sōng-dĕk-sáng Háik-chĭng-só Cái-siék-chṳ̄ Ék-cié-câ" data-language-autonym="閩東語 / Mìng-dĕ̤ng-ngṳ̄" data-language-local-name="Mindong" class="interlanguage-link-target"><span>閩東語 / Mìng-dĕ̤ng-ngṳ̄</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Selektivn%C3%AD_inhibitor_zp%C4%9Btn%C3%A9ho_vychyt%C3%A1v%C3%A1n%C3%AD_serotoninu" title="Selektivní inhibitor zpětného vychytávání serotoninu – เช็ก" lang="cs" hreflang="cs" data-title="Selektivní inhibitor zpětného vychytávání serotoninu" data-language-autonym="Čeština" data-language-local-name="เช็ก" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Selektive_serotoningenoptagsh%C3%A6mmere" title="Selektive serotoningenoptagshæmmere – เดนมาร์ก" lang="da" hreflang="da" data-title="Selektive serotoningenoptagshæmmere" data-language-autonym="Dansk" data-language-local-name="เดนมาร์ก" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Serotonin-Wiederaufnahmehemmer" title="Serotonin-Wiederaufnahmehemmer – เยอรมัน" lang="de" hreflang="de" data-title="Serotonin-Wiederaufnahmehemmer" data-language-autonym="Deutsch" data-language-local-name="เยอรมัน" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%95%CE%BA%CE%BB%CE%B5%CE%BA%CF%84%CE%B9%CE%BA%CF%8C%CF%82_%CE%B1%CE%BD%CE%B1%CF%83%CF%84%CE%BF%CE%BB%CE%AD%CE%B1%CF%82_%CE%B5%CF%80%CE%B1%CE%BD%CE%B1%CF%80%CF%81%CF%8C%CF%83%CE%BB%CE%B7%CF%88%CE%B7%CF%82_%CF%83%CE%B5%CF%81%CE%BF%CF%84%CE%BF%CE%BD%CE%AF%CE%BD%CE%B7%CF%82" title="Εκλεκτικός αναστολέας επαναπρόσληψης σεροτονίνης – กรีก" lang="el" hreflang="el" data-title="Εκλεκτικός αναστολέας επαναπρόσληψης σεροτονίνης" data-language-autonym="Ελληνικά" data-language-local-name="กรีก" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor" title="Selective serotonin reuptake inhibitor – อังกฤษ" lang="en" hreflang="en" data-title="Selective serotonin reuptake inhibitor" data-language-autonym="English" data-language-local-name="อังกฤษ" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Selektiva_malhelpa%C4%B5o_de_realpreno_de_serotonino" title="Selektiva malhelpaĵo de realpreno de serotonino – เอสเปรันโต" lang="eo" hreflang="eo" data-title="Selektiva malhelpaĵo de realpreno de serotonino" data-language-autonym="Esperanto" data-language-local-name="เอสเปรันโต" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Inhibidor_selectivo_de_la_recaptaci%C3%B3n_de_serotonina" title="Inhibidor selectivo de la recaptación de serotonina – สเปน" lang="es" hreflang="es" data-title="Inhibidor selectivo de la recaptación de serotonina" data-language-autonym="Español" data-language-local-name="สเปน" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Selektiivsed_serotoniini_tagasihaarde_inhibiitorid" title="Selektiivsed serotoniini tagasihaarde inhibiitorid – เอสโตเนีย" lang="et" hreflang="et" data-title="Selektiivsed serotoniini tagasihaarde inhibiitorid" data-language-autonym="Eesti" data-language-local-name="เอสโตเนีย" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%85%D9%87%D8%A7%D8%B1%DA%A9%D9%86%D9%86%D8%AF%D9%87_%D8%A7%D9%86%D8%AA%D8%AE%D8%A7%D8%A8%DB%8C_%D8%A8%D8%A7%D8%B2%D8%AC%D8%B0%D8%A8_%D8%B3%D8%B1%D9%88%D8%AA%D9%88%D9%86%DB%8C%D9%86" title="مهارکننده انتخابی بازجذب سروتونین – เปอร์เซีย" lang="fa" hreflang="fa" data-title="مهارکننده انتخابی بازجذب سروتونین" data-language-autonym="فارسی" data-language-local-name="เปอร์เซีย" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Selektiiviset_serotoniinin_takaisinoton_est%C3%A4j%C3%A4t" title="Selektiiviset serotoniinin takaisinoton estäjät – ฟินแลนด์" lang="fi" hreflang="fi" data-title="Selektiiviset serotoniinin takaisinoton estäjät" data-language-autonym="Suomi" data-language-local-name="ฟินแลนด์" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Inhibiteur_s%C3%A9lectif_de_la_recapture_de_la_s%C3%A9rotonine" title="Inhibiteur sélectif de la recapture de la sérotonine – ฝรั่งเศส" lang="fr" hreflang="fr" data-title="Inhibiteur sélectif de la recapture de la sérotonine" data-language-autonym="Français" data-language-local-name="ฝรั่งเศส" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/SSRI" title="SSRI – ฮิบรู" lang="he" hreflang="he" data-title="SSRI" data-language-autonym="עברית" data-language-local-name="ฮิบรู" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Szelekt%C3%ADv_szerotoninvisszav%C3%A9tel-g%C3%A1tl%C3%B3k" title="Szelektív szerotoninvisszavétel-gátlók – ฮังการี" lang="hu" hreflang="hu" data-title="Szelektív szerotoninvisszavétel-gátlók" data-language-autonym="Magyar" data-language-local-name="ฮังการี" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Penghambat_penyerapan_kembali_serotonin_selektif" title="Penghambat penyerapan kembali serotonin selektif – อินโดนีเซีย" lang="id" hreflang="id" data-title="Penghambat penyerapan kembali serotonin selektif" data-language-autonym="Bahasa Indonesia" data-language-local-name="อินโดนีเซีย" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/S%C3%A9rt%C3%A6kir_ser%C3%B3t%C3%B3n%C3%ADn_enduruppt%C3%B6kuhemlar" title="Sértækir serótónín endurupptökuhemlar – ไอซ์แลนด์" lang="is" hreflang="is" data-title="Sértækir serótónín endurupptökuhemlar" data-language-autonym="Íslenska" data-language-local-name="ไอซ์แลนด์" class="interlanguage-link-target"><span>Íslenska</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Inibitori_selettivi_della_ricaptazione_della_serotonina" title="Inibitori selettivi della ricaptazione della serotonina – อิตาลี" lang="it" hreflang="it" data-title="Inibitori selettivi della ricaptazione della serotonina" data-language-autonym="Italiano" data-language-local-name="อิตาลี" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E9%81%B8%E6%8A%9E%E7%9A%84%E3%82%BB%E3%83%AD%E3%83%88%E3%83%8B%E3%83%B3%E5%86%8D%E5%8F%96%E3%82%8A%E8%BE%BC%E3%81%BF%E9%98%BB%E5%AE%B3%E8%96%AC" title="選択的セロトニン再取り込み阻害薬 – ญี่ปุ่น" lang="ja" hreflang="ja" data-title="選択的セロトニン再取り込み阻害薬" data-language-autonym="日本語" data-language-local-name="ญี่ปุ่น" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%A1%E1%83%94%E1%83%A0%E1%83%9D%E1%83%A2%E1%83%9D%E1%83%9C%E1%83%98%E1%83%9C%E1%83%98%E1%83%A1_%E1%83%A3%E1%83%99%E1%83%A3%E1%83%9B%E1%83%98%E1%83%A2%E1%83%90%E1%83%AA%E1%83%94%E1%83%91%E1%83%98%E1%83%A1_%E1%83%A8%E1%83%94%E1%83%A0%E1%83%A9%E1%83%94%E1%83%95%E1%83%98%E1%83%97%E1%83%98_%E1%83%98%E1%83%9C%E1%83%B0%E1%83%98%E1%83%91%E1%83%98%E1%83%A2%E1%83%9D%E1%83%A0%E1%83%98" title="სეროტონინის უკუმიტაცების შერჩევითი ინჰიბიტორი – จอร์เจีย" lang="ka" hreflang="ka" data-title="სეროტონინის უკუმიტაცების შერჩევითი ინჰიბიტორი" data-language-autonym="ქართული" data-language-local-name="จอร์เจีย" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%84%A0%ED%83%9D%EC%A0%81_%EC%84%B8%EB%A1%9C%ED%86%A0%EB%8B%8C_%EC%9E%AC%ED%9D%A1%EC%88%98_%EC%96%B5%EC%A0%9C%EC%A0%9C" title="선택적 세로토닌 재흡수 억제제 – เกาหลี" lang="ko" hreflang="ko" data-title="선택적 세로토닌 재흡수 억제제" data-language-autonym="한국어" data-language-local-name="เกาหลี" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Selektyvieji_serotonino_reabsorbcijos_inhibitoriai" title="Selektyvieji serotonino reabsorbcijos inhibitoriai – ลิทัวเนีย" lang="lt" hreflang="lt" data-title="Selektyvieji serotonino reabsorbcijos inhibitoriai" data-language-autonym="Lietuvių" data-language-local-name="ลิทัวเนีย" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Selekt%C4%ABvie_seroton%C4%ABna_atpaka%C4%BCsaist%C4%AB%C5%A1an%C4%81s_inhibitori" title="Selektīvie serotonīna atpakaļsaistīšanās inhibitori – ลัตเวีย" lang="lv" hreflang="lv" data-title="Selektīvie serotonīna atpakaļsaistīšanās inhibitori" data-language-autonym="Latviešu" data-language-local-name="ลัตเวีย" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A1%D0%B5%D0%BB%D0%B5%D0%BA%D1%82%D0%B8%D0%B2%D0%B5%D0%BD_%D0%B8%D0%BD%D1%85%D0%B8%D0%B1%D0%B8%D1%82%D0%BE%D1%80_%D0%BD%D0%B0_%D1%80%D0%B5%D0%BF%D1%80%D0%B5%D0%B7%D0%B5%D0%BC%D0%B0%D1%9A%D0%B5%D1%82%D0%BE_%D0%BD%D0%B0_%D1%81%D0%B5%D1%80%D0%BE%D1%82%D0%BE%D0%BD%D0%B8%D0%BD%D0%BE%D1%82" title="Селективен инхибитор на репреземањето на серотонинот – มาซิโดเนีย" lang="mk" hreflang="mk" data-title="Селективен инхибитор на репреземањето на серотонинот" data-language-autonym="Македонски" data-language-local-name="มาซิโดเนีย" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Selectieve_serotonine-heropnameremmers" title="Selectieve serotonine-heropnameremmers – ดัตช์" lang="nl" hreflang="nl" data-title="Selectieve serotonine-heropnameremmers" data-language-autonym="Nederlands" data-language-local-name="ดัตช์" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Selektiv_serotoninreopptakshemmer" title="Selektiv serotoninreopptakshemmer – นอร์เวย์บุคมอล" lang="nb" hreflang="nb" data-title="Selektiv serotoninreopptakshemmer" data-language-autonym="Norsk bokmål" data-language-local-name="นอร์เวย์บุคมอล" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B8%E0%AC%BF%E0%AC%B2%E0%AD%87%E0%AC%95%E0%AD%8D%E0%AC%9F%E0%AC%BF%E0%AC%AD_%E0%AC%B8%E0%AD%87%E0%AC%B0%E0%AD%8B%E0%AC%9F%E0%AD%8B%E0%AC%A8%E0%AC%BF%E0%AC%A8_%E0%AC%B0%E0%AC%BF%E0%AC%85%E0%AC%AA%E0%AC%9F%E0%AD%87%E0%AC%95_%E0%AC%87%E0%AC%A8%E0%AC%B9%E0%AC%BF%E0%AC%AC%E0%AC%BF%E0%AC%9F%E0%AC%B0" title="ସିଲେକ୍ଟିଭ ସେରୋଟୋନିନ ରିଅପଟେକ ଇନହିବିଟର – โอดิยา" lang="or" hreflang="or" data-title="ସିଲେକ୍ଟିଭ ସେରୋଟୋନିନ ରିଅପଟେକ ଇନହିବିଟର" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="โอดิยา" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Selektywne_inhibitory_zwrotnego_wychwytu_serotoniny" title="Selektywne inhibitory zwrotnego wychwytu serotoniny – โปแลนด์" lang="pl" hreflang="pl" data-title="Selektywne inhibitory zwrotnego wychwytu serotoniny" data-language-autonym="Polski" data-language-local-name="โปแลนด์" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Inibidor_seletivo_de_recapta%C3%A7%C3%A3o_de_serotonina" title="Inibidor seletivo de recaptação de serotonina – โปรตุเกส" lang="pt" hreflang="pt" data-title="Inibidor seletivo de recaptação de serotonina" data-language-autonym="Português" data-language-local-name="โปรตุเกส" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Inhibitor_selectiv_al_recapt%C4%83rii_de_serotonin%C4%83" title="Inhibitor selectiv al recaptării de serotonină – โรมาเนีย" lang="ro" hreflang="ro" data-title="Inhibitor selectiv al recaptării de serotonină" data-language-autonym="Română" data-language-local-name="โรมาเนีย" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A1%D0%B5%D0%BB%D0%B5%D0%BA%D1%82%D0%B8%D0%B2%D0%BD%D1%8B%D0%B5_%D0%B8%D0%BD%D0%B3%D0%B8%D0%B1%D0%B8%D1%82%D0%BE%D1%80%D1%8B_%D0%BE%D0%B1%D1%80%D0%B0%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D1%85%D0%B2%D0%B0%D1%82%D0%B0_%D1%81%D0%B5%D1%80%D0%BE%D1%82%D0%BE%D0%BD%D0%B8%D0%BD%D0%B0" title="Селективные ингибиторы обратного захвата серотонина – รัสเซีย" lang="ru" hreflang="ru" data-title="Селективные ингибиторы обратного захвата серотонина" data-language-autonym="Русский" data-language-local-name="รัสเซีย" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Selektivni_inhibitor_preuzimanja_serotonina" title="Selektivni inhibitor preuzimanja serotonina – เซอร์โบ-โครเอเชีย" lang="sh" hreflang="sh" data-title="Selektivni inhibitor preuzimanja serotonina" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="เซอร์โบ-โครเอเชีย" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor" title="Selective serotonin reuptake inhibitor – Simple English" lang="en-simple" hreflang="en-simple" data-title="Selective serotonin reuptake inhibitor" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Selektivni_zaviralec_ponovnega_privzema_serotonina" title="Selektivni zaviralec ponovnega privzema serotonina – สโลวีเนีย" lang="sl" hreflang="sl" data-title="Selektivni zaviralec ponovnega privzema serotonina" data-language-autonym="Slovenščina" data-language-local-name="สโลวีเนีย" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Selektivni_inhibitor_preuzimanja_serotonina" title="Selektivni inhibitor preuzimanja serotonina – เซอร์เบีย" lang="sr" hreflang="sr" data-title="Selektivni inhibitor preuzimanja serotonina" data-language-autonym="Српски / srpski" data-language-local-name="เซอร์เบีย" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Selektiva_serotonin%C3%A5terupptagsh%C3%A4mmare" title="Selektiva serotoninåterupptagshämmare – สวีเดน" lang="sv" hreflang="sv" data-title="Selektiva serotoninåterupptagshämmare" data-language-autonym="Svenska" data-language-local-name="สวีเดน" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Selektibong_Tagapigil_ng_Muling_Pagsisipsip_ng_Serotonin" title="Selektibong Tagapigil ng Muling Pagsisipsip ng Serotonin – ตากาล็อก" lang="tl" hreflang="tl" data-title="Selektibong Tagapigil ng Muling Pagsisipsip ng Serotonin" data-language-autonym="Tagalog" data-language-local-name="ตากาล็อก" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Se%C3%A7ici_serotonin_geri_al%C4%B1m_inhibit%C3%B6r%C3%BC" title="Seçici serotonin geri alım inhibitörü – ตุรกี" lang="tr" hreflang="tr" data-title="Seçici serotonin geri alım inhibitörü" data-language-autonym="Türkçe" data-language-local-name="ตุรกี" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A1%D0%B5%D0%BB%D0%B5%D0%BA%D1%82%D0%B8%D0%B2%D0%BD%D1%96_%D1%96%D0%BD%D0%B3%D1%96%D0%B1%D1%96%D1%82%D0%BE%D1%80%D0%B8_%D0%B7%D0%B2%D0%BE%D1%80%D0%BE%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D1%85%D0%BE%D0%BF%D0%BB%D0%B5%D0%BD%D0%BD%D1%8F_%D1%81%D0%B5%D1%80%D0%BE%D1%82%D0%BE%D0%BD%D1%96%D0%BD%D1%83" title="Селективні інгібітори зворотного захоплення серотоніну – ยูเครน" lang="uk" hreflang="uk" data-title="Селективні інгібітори зворотного захоплення серотоніну" data-language-autonym="Українська" data-language-local-name="ยูเครน" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%80%89%E6%8B%A9%E6%80%A75-%E7%BE%9F%E8%89%B2%E8%83%BA%E5%86%8D%E6%91%84%E5%8F%96%E6%8A%91%E5%88%B6%E5%89%82" title="选择性5-羟色胺再摄取抑制剂 – จีน" lang="zh" hreflang="zh" data-title="选择性5-羟色胺再摄取抑制剂" data-language-autonym="中文" data-language-local-name="จีน" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/S%C3%B3an-te%CC%8Dk-s%C3%A8ng_huih-chheng-s%C3%B2%CD%98_ch%C3%A0i-liap-chh%C3%BA_ek-ch%C3%A8-ch%C3%A8" title="Sóan-te̍k-sèng huih-chheng-sò͘ chài-liap-chhú ek-chè-chè – จีนมินหนาน" lang="nan" hreflang="nan" data-title="Sóan-te̍k-sèng huih-chheng-sò͘ chài-liap-chhú ek-chè-chè" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="จีนมินหนาน" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q334477#sitelinks-wikipedia" title="แก้ไขลิงก์ข้ามภาษา" class="wbc-editpage">แก้ไขลิงก์</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> 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.mbox-text-span{margin-left:23px!important}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}</style><table class="plainlinks metadata ambox ambox-style" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Translation_to_Thai_arrow.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Translation_to_Thai_arrow.png/55px-Translation_to_Thai_arrow.png" decoding="async" width="55" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Translation_to_Thai_arrow.png/83px-Translation_to_Thai_arrow.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Translation_to_Thai_arrow.png/110px-Translation_to_Thai_arrow.png 2x" data-file-width="3281" data-file-height="850" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">บทความนี้<a href="/wiki/%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:%E0%B8%9A%E0%B8%97%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B8%97%E0%B8%B5%E0%B9%88%E0%B8%A1%E0%B8%B5%E0%B8%8A%E0%B8%B7%E0%B9%88%E0%B8%AD%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%A0%E0%B8%B2%E0%B8%A9%E0%B8%B2%E0%B8%AD%E0%B8%B1%E0%B8%87%E0%B8%81%E0%B8%A4%E0%B8%A9" title="หมวดหมู่:บทความที่มีชื่อเป็นภาษาอังกฤษ">มีชื่อเป็นภาษาอังกฤษ</a> เนื่องจากชื่อเป็นศัพท์เฉพาะทาง ราชบัณฑิตยสถานยังไม่บัญญัติภาษาไทย หนังสือไทยใช้ศัพท์อังกฤษ</div></td></tr></tbody></table> <table class="infobox" style="width:22em"><tbody><tr><th colspan="2" style="text-align:center;font-size:125%;font-weight:bold;background-color: #ddbbee">Selective serotonin re-uptake inhibitors</th></tr><tr><td colspan="2" style="text-align:center"><i>ระดับชั้นของยา</i></td></tr><tr><td colspan="2" style="text-align:center"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Serotonin-2D-skeletal.svg" class="mw-file-description" title="เซโรโทนิน"><img alt="เซโรโทนิน" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c4/Serotonin-2D-skeletal.svg/280px-Serotonin-2D-skeletal.svg.png" decoding="async" width="280" height="203" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c4/Serotonin-2D-skeletal.svg/420px-Serotonin-2D-skeletal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c4/Serotonin-2D-skeletal.svg/560px-Serotonin-2D-skeletal.svg.png 2x" data-file-width="512" data-file-height="371" /></a></span><div><a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99" title="เซโรโทนิน">เซโรโทนิน</a></div></td></tr><tr><th colspan="2" style="text-align:center;background: #e8e8e8;">Class identifiers</th></tr><tr><th scope="row">ใช้ใน</th><td><a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="โรคซึมเศร้า">โรคซึมเศร้า</a>, <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A7%E0%B8%B4%E0%B8%95%E0%B8%81%E0%B8%81%E0%B8%B1%E0%B8%87%E0%B8%A7%E0%B8%A5" title="โรควิตกกังวล">โรควิตกกังวล</a></td></tr><tr><th scope="row"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" class="mw-redirect" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td><a href="/w/index.php?title=ATC_code_N06AB&amp;action=edit&amp;redlink=1" class="new" title="ATC code N06AB (ไม่มีหน้านี้)">N06AB</a></td></tr><tr><th scope="row"><a href="/w/index.php?title=Biological_target&amp;action=edit&amp;redlink=1" class="new" title="Biological target (ไม่มีหน้านี้)">Biological target</a></th><td>Serotonin transporter</td></tr><tr><th colspan="2" style="text-align:center;background: #e8e8e8;">Clinical data</th></tr><tr><th scope="row"><a href="/w/index.php?title=Drugs.com&amp;action=edit&amp;redlink=1" class="new" title="Drugs.com (ไม่มีหน้านี้)">Drugs.com</a></th><td><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/drug-class/ssri-antidepressants.html">Drug Classes</a></span></td></tr><tr><th scope="row"><a href="/w/index.php?title=Consumer_Reports&amp;action=edit&amp;redlink=1" class="new" title="Consumer Reports (ไม่มีหน้านี้)">Consumer Reports</a></th><td><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.consumerreports.org/health/best-buy-drugs/antidepressants.htm">Best Buy Drugs</a></span></td></tr><tr><th colspan="2" style="text-align:center;background: #e8e8e8;">External links</th></tr><tr><th scope="row"><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">MeSH</a></th><td><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?field=uid&amp;term=D017367">D017367</a></span></td></tr><tr><td colspan="2" style="text-align:center;background: #e8e8e8; text-align: center"><a href="https://www.wikidata.org/wiki/Q334477" class="extiw" title="d:Q334477">In Wikidata</a></td></tr></tbody></table> <p><b>Selective serotonin re-uptake inhibitors</b> หรือ <b>serotonin-specific reuptake inhibitors</b><sup id="cite_ref-BARLOW_1-0" class="reference"><a href="#cite_note-BARLOW-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> (ตัวย่อ <b>SSRI</b>, <b>SSRIs</b>) เป็นกลุ่มยา (class of drugs) ที่ปกติใช้เป็น<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="ยาแก้ซึมเศร้า">ยาแก้ซึมเศร้า</a>เพื่อรักษา<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="โรคซึมเศร้า">โรคซึมเศร้า</a> (MDD) และ<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A7%E0%B8%B4%E0%B8%95%E0%B8%81%E0%B8%81%E0%B8%B1%E0%B8%87%E0%B8%A7%E0%B8%A5" title="โรควิตกกังวล">โรควิตกกังวล</a> กลไกการทำงานของ SSRIs ยังเป็นเรื่องไม่ชัดเจน<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> แต่เชื่อว่า SSRI เพิ่มระดับ<a href="/wiki/%E0%B8%AA%E0%B8%B2%E0%B8%A3%E0%B8%AA%E0%B8%B7%E0%B9%88%E0%B8%AD%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="สารสื่อประสาท">สารสื่อประสาท</a><a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99" title="เซโรโทนิน">เซโรโทนิน</a>นอก<a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B8%A5%E0%B8%A5%E0%B9%8C%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="เซลล์ประสาท">เซลล์ประสาท</a>โดยจำกัดการนำไปใช้ใหม่ในเซลล์ก่อน<a href="/wiki/%E0%B9%84%E0%B8%8B%E0%B9%81%E0%B8%99%E0%B8%9B%E0%B8%AA%E0%B9%8C" class="mw-redirect" title="ไซแนปส์">ไซแนปส์</a> (presynaptic) เป็นการเพิ่มระดับเซโรโทนินในช่องไซแนปส์ (synaptic cleft) ที่สามารถเข้ายึดกับ<a href="/wiki/%E0%B8%95%E0%B8%B1%E0%B8%A7%E0%B8%A3%E0%B8%B1%E0%B8%9A" class="mw-redirect" title="ตัวรับ">ตัวรับ</a> (receptor) ของเซลล์หลังไซแนปส์ (postsynaptic) ได้ ยาแต่ละประเภทมีการเลือกสรร (selectivity) ในระดับต่าง ๆ กันต่อตัวขนส่งโมโนอะมีนประเภทอื่น ๆ แต่ SSRIs แบบบริสุทธิ์จะมี<a href="/wiki/%E0%B8%AA%E0%B8%B1%E0%B8%A1%E0%B8%9E%E0%B8%A3%E0%B8%A3%E0%B8%84%E0%B8%A0%E0%B8%B2%E0%B8%9E" class="mw-redirect" title="สัมพรรคภาพ">สัมพรรคภาพ</a> (affinity) ที่อ่อนต่อ<a href="/wiki/%E0%B9%82%E0%B8%9B%E0%B8%A3%E0%B8%95%E0%B8%B5%E0%B8%99" title="โปรตีน">โปรตีน</a>ขนส่งนอร์เอพิเนฟรินและโปรตีนขนส่งโดพามีน </p><p>SSRIs เป็นยาแก้ซึมเศร้าที่แพทย์สั่งให้คนไข้มากที่สุดในประเทศหลาย ๆ ประเทศ<sup id="cite_ref-PRESCORN2004_3-0" class="reference"><a href="#cite_note-PRESCORN2004-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> แต่ประสิทธิผลของ SSRIs ต่อโรคซึมเศร้าในระดับอ่อนหรือปานกลางยังเป็นเรื่องขัดแย้ง<sup id="cite_ref-JAMA2010_4-0" class="reference"><a href="#cite_note-JAMA2010-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Kramer_5-0" class="reference"><a href="#cite_note-Kramer-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Pies_6-0" class="reference"><a href="#cite_note-Pies-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r8283561">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="การใช้ในการแพทย์"><span id=".E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B9.83.E0.B8.8A.E0.B9.89.E0.B9.83.E0.B8.99.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B9.81.E0.B8.9E.E0.B8.97.E0.B8.A2.E0.B9.8C"></span>การใช้ในการแพทย์</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=1" title="แก้ไขส่วน: การใช้ในการแพทย์"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ข้อบ่งใช้หลักของ SSRIs ก็คือ<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="โรคซึมเศร้า">โรคซึมเศร้า</a> (MDD) แต่ SSRIs บ่อยครั้งใช้สำหรับ<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A7%E0%B8%B4%E0%B8%95%E0%B8%81%E0%B8%81%E0%B8%B1%E0%B8%87%E0%B8%A7%E0%B8%A5" title="โรควิตกกังวล">โรควิตกกังวล</a>ด้วย เช่น โรควิตกกังวลทางสังคม (social anxiety disorder) <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%95%E0%B8%B7%E0%B9%88%E0%B8%99%E0%B8%95%E0%B8%A3%E0%B8%B0%E0%B8%AB%E0%B8%99%E0%B8%81" title="โรคตื่นตระหนก">โรคตื่นตระหนก</a> <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%84%E0%B8%B4%E0%B8%94%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%97%E0%B8%B3" title="โรคย้ำคิดย้ำทำ">โรคย้ำคิดย้ำทำ</a> (OCD) ความผิดปกติในการรับประทาน (eating disorder) ความเจ็บปวดที่เรื้อรัง และเป็นบางครั้งสำหรับ<a href="/wiki/%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B8%9C%E0%B8%B4%E0%B8%94%E0%B8%9B%E0%B8%81%E0%B8%95%E0%B8%B4%E0%B8%97%E0%B8%B5%E0%B9%88%E0%B9%80%E0%B8%81%E0%B8%B4%E0%B8%94%E0%B8%AB%E0%B8%A5%E0%B8%B1%E0%B8%87%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B5%E0%B8%A2%E0%B8%94%E0%B8%97%E0%B8%B5%E0%B9%88%E0%B8%AA%E0%B8%B0%E0%B9%80%E0%B8%97%E0%B8%B7%E0%B8%AD%E0%B8%99%E0%B9%83%E0%B8%88" title="ความผิดปกติที่เกิดหลังความเครียดที่สะเทือนใจ">ความผิดปกติที่เกิดหลังความเครียดที่สะเทือนใจ</a> (PTSD) และบ่อยครั้งใช้รักษา depersonalization disorder (โรคที่รู้สึกว่าร่างกาย ความคิด หรือ<a href="/wiki/%E0%B8%AD%E0%B8%B2%E0%B8%A3%E0%B8%A1%E0%B8%93%E0%B9%8C" title="อารมณ์">อารมณ์</a>ความรู้สึกไม่ใช่ของตน) ด้วย แม้ว่าโดยทั่วไปจะไม่ได้ผลดี<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="โรคซึมเศร้า"><span id=".E0.B9.82.E0.B8.A3.E0.B8.84.E0.B8.8B.E0.B8.B6.E0.B8.A1.E0.B9.80.E0.B8.A8.E0.B8.A3.E0.B9.89.E0.B8.B2"></span>โรคซึมเศร้า</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=2" title="แก้ไขส่วน: โรคซึมเศร้า"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r9751016">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}</style><div role="note" class="hatnote navigation-not-searchable">บทความหลัก: <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="โรคซึมเศร้า">โรคซึมเศร้า</a></div> <p>องค์การกระทรวงสาธารณสุขของ<a href="/wiki/%E0%B8%AA%E0%B8%AB%E0%B8%A3%E0%B8%B2%E0%B8%8A%E0%B8%AD%E0%B8%B2%E0%B8%93%E0%B8%B2%E0%B8%88%E0%B8%B1%E0%B8%81%E0%B8%A3" title="สหราชอาณาจักร">สหราชอาณาจักร</a> (NICE) แนะนำยาแก้ซึมเศร้าเป็นการรักษาลำดับต้นของโรคซึมเศร้าขั้นรุนแรง และเป็นลำดับต่อไปหลังรักษาด้วยวิธีอื่น ๆ เช่นการบำบัดความคิด (cognitive therapy) ถ้าโรคคงยืนสำหรับโรคขั้นอ่อนถึงปานกลาง<sup id="cite_ref-NICE2009_8-0" class="reference"><a href="#cite_note-NICE2009-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> และแนะนำไม่ให้ใช้เป็นปกติในบุคคลที่มีปัญหาสุขภาพเรื้อรังหรือมีโรคซึมเศร้าแบบอ่อน<sup id="cite_ref-NICE2009_8-1" class="reference"><a href="#cite_note-NICE2009-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> มีข้อขัดแย้งกันในเรื่องประสิทธิผลของยาในการรักษาโรคที่ขึ้นอยู่กับความรุนแรงและระยะเวลาที่เป็นโรค </p> <ul><li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a> 2 งานปี 2551 และ 2553 พบว่า ในโรคขั้นอ่อนและปานกลาง ผลของ SSRIs น้อยหรือไม่มีเทียบกับ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%81" title="ยาหลอก">ยาหลอก</a> และในโรคที่รุนแรงมาก ผลอยู่ระหว่าง "ค่อนข้างน้อย" และ "มาก"<sup id="cite_ref-JAMA2010_4-1" class="reference"><a href="#cite_note-JAMA2010-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-KIRSCH2008_9-0" class="reference"><a href="#cite_note-KIRSCH2008-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> งานปี 2551 ได้รวบรวมงานทดลองทางคลินิก 35 งานที่ยื่นให้กับ<a href="/wiki/%E0%B8%AD%E0%B8%87%E0%B8%84%E0%B9%8C%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%AD%E0%B8%B2%E0%B8%AB%E0%B8%B2%E0%B8%A3%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A2%E0%B8%B2" class="mw-disambig" title="องค์การอาหารและยา">องค์การอาหารและยา</a>สหรัฐ (FDA) ก่อนอนุมัติให้ใช้ยาแก้ซึมเศร้าใหม่ ๆ 4 อย่าง (รวมทั้งยา SSRIs คือ paroxetine กับ<a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>, ยา non-SSRI คือ nefazodone, และยา SNRI คือ venlafaxine) ผู้เขียนยกประสิทธิผลที่ปรากฏต่อคนไข้ขั้นรุนแรงว่าเป็นเพราะการลดระดับปรากฏการณ์ยาหลอกในคนไข้กลุ่มนี้ และไม่ใช่ผลที่เพิ่มขึ้นของยา<sup id="cite_ref-KIRSCH2008_9-1" class="reference"><a href="#cite_note-KIRSCH2008-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> แต่นักวิจัยบางพวกตั้งข้อสงสัยถึงวิธีการทางสถิติของงานนี้โดยเสนอว่า งานประเมินผลต่างของยาแก้ซึมเศร้าน้อยเกินไป<sup id="cite_ref-HORDER2010_10-0" class="reference"><a href="#cite_note-HORDER2010-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-FOUNTOULAKIS2010_11-0" class="reference"><a href="#cite_note-FOUNTOULAKIS2010-11"><span class="cite-bracket">&#91;</span>11<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%97%E0%B8%9A%E0%B8%97%E0%B8%A7%E0%B8%99%E0%B8%A7%E0%B8%A3%E0%B8%A3%E0%B8%93%E0%B8%81%E0%B8%A3%E0%B8%A3%E0%B8%A1" class="mw-redirect" title="งานทบทวนวรรณกรรม">งานทบทวนวรรณกรรม</a>ที่กว้างขวางปี 2553 ของ NICE สรุปว่า ยาแก้ซึมเศร้าไม่มีประโยชน์กว่ายาหลอกเพื่อรักษาโรคขั้นอ่อนที่มีระยะสั้น แต่หลักฐานที่มีสนับสนุนการใช้ยาเพื่อรักษา dysthymia และรูปแบบอื่น ๆ ของโรคขั้นอ่อนแต่เรื้อรัง<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ปี 2555 เกี่ยวกับ<a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>และ venlafaxine สรุปว่า ยาทั้งสองมีผลต่างที่มีนัยสำคัญทั้ง<a href="/wiki/%E0%B8%99%E0%B8%B1%E0%B8%A2%E0%B8%AA%E0%B8%B3%E0%B8%84%E0%B8%B1%E0%B8%8D%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%AA%E0%B8%96%E0%B8%B4%E0%B8%95%E0%B8%B4" title="นัยสำคัญทางสถิติ">ทางสถิติ</a>และทางคลินิก เทียบกับยาหลอก ไม่ว่าโรคจะรุนแรงแค่ไหน<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup></li> <li>ในปี 2557 FDA ตีพิมพ์<a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%9B%E0%B8%A3%E0%B8%B4%E0%B8%97%E0%B8%B1%E0%B8%A8%E0%B8%99%E0%B9%8C%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A" class="mw-redirect" title="งานปริทัศน์เป็นระบบ">งานปริทัศน์เป็นระบบ</a>ของการทดลองใช้ยาแก้ซึมเศร้าเพื่อดำรงรักษาสภาพ (maintenance) ที่ส่งให้องค์การระหว่างปี 2528-2555 ผู้เขียนสรุปว่า การรักษาเพื่อดำรงสภาพลดความเสี่ยงการเกิดโรคอีก 52% เทียบกับยาหลอก และผลต่างที่ว่านี้เป็นเพราะการเกิดโรคซ้ำ ๆ ในกลุ่มยาหลอก ไม่ใช่ผลจากการขาดยา (withdrawal)<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">&#91;</span>14<span class="cite-bracket">&#93;</span></a></sup></li></ul> <p>งานวิเคราะห์อภิมานปี 2554 แสดงว่า ประสิทธิผลระหว่างยาแก้ซึมเศร้ารุ่นที่สองต่าง ๆ (second generation) ไม่ต่างกันมาก<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">&#91;</span>15<span class="cite-bracket">&#93;</span></a></sup> </p><p>ในเด็ก มีความเป็นห่วงว่าคุณภาพของหลักฐานที่มีอาจทำให้ประโยชน์ที่ปรากฏไม่มีความหมาย<sup id="cite_ref-Hewt2012_16-0" class="reference"><a href="#cite_note-Hewt2012-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> ถ้าใช้ยารักษาเด็ก <a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>ดูจะเป็นยาลำดับแรก<sup id="cite_ref-Hewt2012_16-1" class="reference"><a href="#cite_note-Hewt2012-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="โรควิตกกังวลทั่วไป"><span id=".E0.B9.82.E0.B8.A3.E0.B8.84.E0.B8.A7.E0.B8.B4.E0.B8.95.E0.B8.81.E0.B8.81.E0.B8.B1.E0.B8.87.E0.B8.A7.E0.B8.A5.E0.B8.97.E0.B8.B1.E0.B9.88.E0.B8.A7.E0.B9.84.E0.B8.9B"></span>โรควิตกกังวลทั่วไป</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=3" title="แก้ไขส่วน: โรควิตกกังวลทั่วไป"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r9751016"><div role="note" class="hatnote navigation-not-searchable">ข้อมูลเพิ่มเติม: <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A7%E0%B8%B4%E0%B8%95%E0%B8%81%E0%B8%81%E0%B8%B1%E0%B8%87%E0%B8%A7%E0%B8%A5" title="โรควิตกกังวล">โรควิตกกังวล</a></div> <p>NICE แนะนำให้ใช้ SSRIs รักษาโรควิตกกังวลทั่วไป (GAD) ที่ไม่ตอบสนองต่อการรักษาแบบอนุรักษ์อื่น ๆ เช่นการให้การศึกษาและการช่วยตนเอง GAD เป็นโรคสามัญที่อาการหลักก็คือความเป็นห่วงมากเกินไปเกี่ยวกับเหตุการณ์ปัญหาต่าง ๆ และความลำบากในการควบคุมความคิดเป็นห่วงที่คงยืนอย่างน้อยเป็นระยะ 6 เดือน </p><p>ยาแก้ซึมเศร้าลดความวิตกกังวลใน GAD ในระดับพอประมาณจนถึงปานกลาง<sup id="cite_ref-urlwww.nice.org.ukb_17-0" class="reference"><a href="#cite_note-urlwww.nice.org.ukb-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup> และดีกว่า<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%81" title="ยาหลอก">ยาหลอก</a><sup id="cite_ref-Kapczinski_18-0" class="reference"><a href="#cite_note-Kapczinski-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> ประสิทธิผลของยาแก้ซึมเศร้ากกลุ่มต่าง ๆ ล้วนคล้ายคลึงกัน<sup id="cite_ref-urlwww.nice.org.ukb_17-1" class="reference"><a href="#cite_note-urlwww.nice.org.ukb-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Kapczinski_18-1" class="reference"><a href="#cite_note-Kapczinski-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="โรคย้ำคิดย้ำทำ_(OCD)"><span id=".E0.B9.82.E0.B8.A3.E0.B8.84.E0.B8.A2.E0.B9.89.E0.B8.B3.E0.B8.84.E0.B8.B4.E0.B8.94.E0.B8.A2.E0.B9.89.E0.B8.B3.E0.B8.97.E0.B8.B3_.28OCD.29"></span>โรคย้ำคิดย้ำทำ (OCD)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=4" title="แก้ไขส่วน: โรคย้ำคิดย้ำทำ (OCD)"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r9751016"><div role="note" class="hatnote navigation-not-searchable">ข้อมูลเพิ่มเติม: <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%84%E0%B8%B4%E0%B8%94%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%97%E0%B8%B3" title="โรคย้ำคิดย้ำทำ">โรคย้ำคิดย้ำทำ</a></div> <p>SSRIs ใช้เป็นการรักษาลำดับสองสำหรับโรคย้ำคิดย้ำทำ (OCD) ในผู้ใหญ่ที่มี<a href="/wiki/%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B8%9E%E0%B8%B4%E0%B8%81%E0%B8%B2%E0%B8%A3" title="ความพิการ">ความพิการ</a>ขั้นอ่อน และลำดับหนึ่งสำหรับผู้มีความพิการปานกลางจนถึงรุนแรง ในเด็ก SSRIs พิจารณาว่าเป็นการรักษาลำดับสองสำหรับเด็กพิการปานกลางจนถึงรุนแรง โดยต้องดูแลอย่างใกล้ชิดเพื่อเช็ค<a href="/wiki/%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B8%9E%E0%B8%B6%E0%B8%87%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%87%E0%B8%84%E0%B9%8C%E0%B8%88%E0%B8%B2%E0%B8%81%E0%B8%A2%E0%B8%B2" title="อาการไม่พึงประสงค์จากยา">ผลที่ไม่พึงประสงค์</a>ทางจิตเวช<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">&#91;</span>19<span class="cite-bracket">&#93;</span></a></sup> SSRIs มีประสิทธิผลในการรักษา OCD เป็นสองเท่าเทียบกับ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%81" title="ยาหลอก">ยาหลอก</a><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">&#91;</span>20<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">&#91;</span>21<span class="cite-bracket">&#93;</span></a></sup> ประสิทธิผลปรากฏทั้งในงานทดลองระยะสั้นเป็นเวลา 6-24 สัปดาห์และงานทดลองแบบ discontinuation (ซึ่งแบ่งระยะออกเป็น 2 ช่วงที่เมื่อถึงระยะที่สอง จะหยุดการทดลองกับผู้ป่วยที่ไม่ตอบสนองต่อวิธีรักษาใหม่ที่ให้อย่างเปิดเผยในระยะแรก<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup>) เป็นระยะ 28-52 สัปดาห์<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">&#91;</span>23<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">&#91;</span>24<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">&#91;</span>25<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="ความผิดปกติในการรับประทาน"><span id=".E0.B8.84.E0.B8.A7.E0.B8.B2.E0.B8.A1.E0.B8.9C.E0.B8.B4.E0.B8.94.E0.B8.9B.E0.B8.81.E0.B8.95.E0.B8.B4.E0.B9.83.E0.B8.99.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.A3.E0.B8.B1.E0.B8.9A.E0.B8.9B.E0.B8.A3.E0.B8.B0.E0.B8.97.E0.B8.B2.E0.B8.99"></span>ความผิดปกติในการรับประทาน</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=5" title="แก้ไขส่วน: ความผิดปกติในการรับประทาน"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>NICE แนะนำ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="ยาแก้ซึมเศร้า">ยาแก้ซึมเศร้า</a>เป็นการรักษาทางเลือกหรือการรักษาเพิ่มในขั้นแรก ที่ใช้ในโปรแกรมช่วยตัวเองเพื่อรักษาโรคหิวไม่หายแบบทานแล้วอาเจียน (bulimia nervosa)<sup id="cite_ref-urlwww.nice.org.uk_26-0" class="reference"><a href="#cite_note-urlwww.nice.org.uk-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup> ยา <a href="/wiki/SSRIs" class="mw-redirect" title="SSRIs">SSRIs</a> โดยเฉพาะ<a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>จะนิยมมากกว่ายาแก้ซึมเศร้าแบบอื่น ๆ เนื่องจากการยอมรับได้ การอดทนได้ และการลดระดับอาการที่ดีกว่าในการทดลองระยะสั้น ส่วนประสิทธิผลระยะยาวยังไม่ชัดเจน </p><p>NICE แนะนำแบบเดียวกันสำหรับ binge eating disorder (โรคหิวไม่หายแบบไม่อาเจียน)<sup id="cite_ref-urlwww.nice.org.uk_26-1" class="reference"><a href="#cite_note-urlwww.nice.org.uk-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup> โดย SSRIs จะลดพฤติกรรมทานมากเกินไปในระยะสั้น แต่ไม่สัมพันธ์กับการลดน้ำหนักอย่างสำคัญ<sup id="cite_ref-urlNational_Guideline_Clearinghouse_&#124;_Practice_guideline_for_the_treatment_of_patients_with_eating_disorders._27-0" class="reference"><a href="#cite_note-urlNational_Guideline_Clearinghouse_|_Practice_guideline_for_the_treatment_of_patients_with_eating_disorders.-27"><span class="cite-bracket">&#91;</span>27<span class="cite-bracket">&#93;</span></a></sup> </p><p>งานทดลองทางคลินิกโดยมากให้ผลลบต่อการใช้ SSRIs เพื่อรักษาโรคเบื่ออาหารเหตุจิตใจ (anorexia nervosa)<sup id="cite_ref-pmid21414249_28-0" class="reference"><a href="#cite_note-pmid21414249-28"><span class="cite-bracket">&#91;</span>28<span class="cite-bracket">&#93;</span></a></sup> NICE<sup id="cite_ref-urlwww.nice.org.uk_26-2" class="reference"><a href="#cite_note-urlwww.nice.org.uk-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup> แนะนำไม่ให้ใช้ SSRIs สำหรับโรคนี้ ส่วนแนวทางจากสมาคมจิตเวชอเมริกัน (APA) ให้ข้อสังเกตว่า SSRIs ไม่มีผลเพิ่มน้ำหนัก แต่อาจใช้รักษาโรคซึมเศร้า โรควิตกกังวล และโรคย้ำคิดย้ำทำที่เป็นไปด้วยกัน<sup id="cite_ref-urlNational_Guideline_Clearinghouse_&#124;_Practice_guideline_for_the_treatment_of_patients_with_eating_disorders._27-1" class="reference"><a href="#cite_note-urlNational_Guideline_Clearinghouse_|_Practice_guideline_for_the_treatment_of_patients_with_eating_disorders.-27"><span class="cite-bracket">&#91;</span>27<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="การฟื้นสภาพจากโรคหลอดเลือดสมอง"><span id=".E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.9F.E0.B8.B7.E0.B9.89.E0.B8.99.E0.B8.AA.E0.B8.A0.E0.B8.B2.E0.B8.9E.E0.B8.88.E0.B8.B2.E0.B8.81.E0.B9.82.E0.B8.A3.E0.B8.84.E0.B8.AB.E0.B8.A5.E0.B8.AD.E0.B8.94.E0.B9.80.E0.B8.A5.E0.B8.B7.E0.B8.AD.E0.B8.94.E0.B8.AA.E0.B8.A1.E0.B8.AD.E0.B8.87"></span>การฟื้นสภาพจากโรคหลอดเลือดสมอง</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=6" title="แก้ไขส่วน: การฟื้นสภาพจากโรคหลอดเลือดสมอง"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>มีการใช้ SSRIs รักษาคนไข้<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%94%E0%B9%80%E0%B8%A5%E0%B8%B7%E0%B8%AD%E0%B8%94%E0%B8%AA%E0%B8%A1%E0%B8%AD%E0%B8%87" title="โรคหลอดเลือดสมอง">โรคหลอดเลือดสมอง</a> ทั้งมีและไม่มีอาการซึมเศร้า <a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ปี 2555 ที่ตรวจดู<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%97%E0%B8%94%E0%B8%A5%E0%B8%AD%E0%B8%87%E0%B9%81%E0%B8%9A%E0%B8%9A%E0%B8%AA%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A1%E0%B8%B5%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%84%E0%B8%A7%E0%B8%9A%E0%B8%84%E0%B8%B8%E0%B8%A1" title="การทดลองแบบสุ่มและมีกลุ่มควบคุม">การทดลองทางคลินิกแบบสุ่มและมีกลุ่มควบคุม</a>พบผลที่มี<a href="/wiki/%E0%B8%99%E0%B8%B1%E0%B8%A2%E0%B8%AA%E0%B8%B3%E0%B8%84%E0%B8%B1%E0%B8%8D%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%AA%E0%B8%96%E0%B8%B4%E0%B8%95%E0%B8%B4" title="นัยสำคัญทางสถิติ">นัยสำคัญทางสถิติ</a>ของ SSRIs ต่อการต้องพึ่งคนอื่น ความบกพร่องทางประสาท อารมณ์ซึมเศร้า และความวิตกกังวล แต่ไม่มีผลที่มี<a href="/wiki/%E0%B8%99%E0%B8%B1%E0%B8%A2%E0%B8%AA%E0%B8%B3%E0%B8%84%E0%B8%B1%E0%B8%8D%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%AA%E0%B8%96%E0%B8%B4%E0%B8%95%E0%B8%B4" title="นัยสำคัญทางสถิติ">นัยสำคัญทางสถิติ</a>ต่อ<a href="/wiki/%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B8%95%E0%B8%B2%E0%B8%A2" title="ความตาย">ความตาย</a> ความบกพร่องในการเคลื่อนไหว หรือ<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A3%E0%B8%B9%E0%B9%89%E0%B8%84%E0%B8%B4%E0%B8%94" class="mw-redirect" title="การรู้คิด">การรู้คิด</a><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="การหลั่งน้ำอสุจิเร็วเกินไป"><span id=".E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.AB.E0.B8.A5.E0.B8.B1.E0.B9.88.E0.B8.87.E0.B8.99.E0.B9.89.E0.B8.B3.E0.B8.AD.E0.B8.AA.E0.B8.B8.E0.B8.88.E0.B8.B4.E0.B9.80.E0.B8.A3.E0.B9.87.E0.B8.A7.E0.B9.80.E0.B8.81.E0.B8.B4.E0.B8.99.E0.B9.84.E0.B8.9B"></span>การหลั่งน้ำอสุจิเร็วเกินไป</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=7" title="แก้ไขส่วน: การหลั่งน้ำอสุจิเร็วเกินไป"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs มีประสิทธิผลในการรักษาการหลั่งน้ำอสุจิเร็วเกินไป การทานยาเป็นประจำมีประสิทธิผลดีกว่าทานยาเมื่อจำเป็น<sup id="cite_ref-pmid17983899_30-0" class="reference"><a href="#cite_note-pmid17983899-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="ผลไม่พึงประสงค์"><span id=".E0.B8.9C.E0.B8.A5.E0.B9.84.E0.B8.A1.E0.B9.88.E0.B8.9E.E0.B8.B6.E0.B8.87.E0.B8.9B.E0.B8.A3.E0.B8.B0.E0.B8.AA.E0.B8.87.E0.B8.84.E0.B9.8C"></span>ผลไม่พึงประสงค์</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=8" title="แก้ไขส่วน: ผลไม่พึงประสงค์"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ยาต่าง ๆ กันในกลุ่มนี้มีผลข้างเคียงต่างกัน แต่ว่า ก็ยังมี<a href="/wiki/%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B8%9E%E0%B8%B6%E0%B8%87%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%87%E0%B8%84%E0%B9%8C%E0%B8%88%E0%B8%B2%E0%B8%81%E0%B8%A2%E0%B8%B2" title="อาการไม่พึงประสงค์จากยา">ผลที่ไม่พึงประสงค์</a>บางอย่างที่พบอย่างกว้าง ๆ ในยาโดยมากถ้าไม่ทั้งหมด ก็คือ </p> <ul><li>เพิ่มความเสี่ยง<a href="/wiki/%E0%B8%81%E0%B8%A3%E0%B8%B0%E0%B8%94%E0%B8%B9%E0%B8%81%E0%B8%AB%E0%B8%B1%E0%B8%81" title="กระดูกหัก">กระดูกหัก</a>เป็น 1.7 เท่า<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">&#91;</span>31<span class="cite-bracket">&#93;</span></a></sup></li> <li>อาการนั่งไม่ติดที่ (akathisia)<sup id="cite_ref-pmid21406165_32-0" class="reference"><a href="#cite_note-pmid21406165-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid9694033_33-0" class="reference"><a href="#cite_note-pmid9694033-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid19289334_34-0" class="reference"><a href="#cite_note-pmid19289334-34"><span class="cite-bracket">&#91;</span>34<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid8909330_35-0" class="reference"><a href="#cite_note-pmid8909330-35"><span class="cite-bracket">&#91;</span>35<span class="cite-bracket">&#93;</span></a></sup></li> <li>ความคิดเรื่องฆ่าตัวตาย (suicidal ideation)</li> <li>การไวแสง<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">&#91;</span>36<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="ความผิดปกติทางเพศ"><span id=".E0.B8.84.E0.B8.A7.E0.B8.B2.E0.B8.A1.E0.B8.9C.E0.B8.B4.E0.B8.94.E0.B8.9B.E0.B8.81.E0.B8.95.E0.B8.B4.E0.B8.97.E0.B8.B2.E0.B8.87.E0.B9.80.E0.B8.9E.E0.B8.A8"></span>ความผิดปกติทางเพศ</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=9" title="แก้ไขส่วน: ความผิดปกติทางเพศ"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs สามารถก่อความผิดปกติทางเพศ (sexual dysfunction) ได้หลายอย่าง เช่น การไม่สามารถบรรลุจุดสุดยอด (anorgasmia) อวัยวะเพศไม่ตอบสนอง (erectile dysfunction) ความต้องการทางเพศที่ลดลง (diminished libido) และภาวะไร้ความยินดีทางเพศ (คือบรรลุจุดสุดยอดโดยไม่ได้ความสุข)<sup id="cite_ref-Bahrick_37-0" class="reference"><a href="#cite_note-Bahrick-37"><span class="cite-bracket">&#91;</span>37<span class="cite-bracket">&#93;</span></a></sup> ปัญหาทางเพศเป็นเรื่องปกติในการทาน SSRIs<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">&#91;</span>38<span class="cite-bracket">&#93;</span></a></sup> ซึ่งเป็นเหตุสามัญที่สุดอย่างหนึ่งที่คนไข้เลิกใช้ยา<sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">&#91;</span>39<span class="cite-bracket">&#93;</span></a></sup> </p><p>บางครั้งบางคราว อาการผิดปกติทางเพศอาจคงยืนแม้เมื่อเลิกยาแล้ว<sup id="cite_ref-Bahrick_37-1" class="reference"><a href="#cite_note-Bahrick-37"><span class="cite-bracket">&#91;</span>37<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">&#91;</span>40<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">&#91;</span>42<span class="cite-bracket">&#93;</span></a></sup> </p><p>กลไกที่ SSRIs เป็นเหตุให้เกิดผลข้างเคียงทางเพศยังไม่ชัดเจนโดยปี 2558 แต่กลไกที่เป็นไปได้รวมทั้ง<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">&#91;</span>43<span class="cite-bracket">&#93;</span></a></sup> </p> <ol><li>ผลทางประสาทที่ไม่เฉพาะเจาะจง (เช่น การระงับประสาท &#91;sedation&#93;) ที่มีผลต่อพฤติกรรมทั่วไปรวมทั้งทางเพศ</li> <li>ผลโดยเฉพาะต่อ<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="ระบบประสาท">ระบบประสาท</a>ที่อำนวยการทางเพศ</li> <li>ผลโดยเฉพาะต่อระบบนอกประสาทกลาง คือต่อ<a href="/wiki/%E0%B9%80%E0%B8%99%E0%B8%B7%E0%B9%89%E0%B8%AD%E0%B9%80%E0%B8%A2%E0%B8%B7%E0%B9%88%E0%B8%AD" title="เนื้อเยื่อ">เนื้อเยื่อ</a>และ<a href="/wiki/%E0%B8%AD%E0%B8%A7%E0%B8%B1%E0%B8%A2%E0%B8%A7%E0%B8%B0" title="อวัยวะ">อวัยวะ</a>ที่อำนวยการทางเพศ เช่น <a href="/wiki/%E0%B8%AD%E0%B8%87%E0%B8%84%E0%B8%8A%E0%B8%B2%E0%B8%95" title="องคชาต">องคชาต</a></li> <li>ผลโดยตรงหรือโดยอ้อมต่อ<a href="/wiki/%E0%B8%AE%E0%B8%AD%E0%B8%A3%E0%B9%8C%E0%B9%82%E0%B8%A1%E0%B8%99" title="ฮอร์โมน">ฮอร์โมน</a>ที่อำนวยการทางเพศ</li></ol> <p>เป็นไปได้ว่า ยาแก้ซึมเศร้ามีผลต่อระบบสรีรภาพหลายอย่างที่มีหน้าที่ทางเพศ งานวิจัยในสัตว์และข้อมูลงานศึกษาในมนุษย์แสดงว่า การทำงานของระบบโดพามีนในสมองมากขึ้นจะกระตุ้นพฤติกรรมและหน้าที่ทางเพศ และการทำงานของระบบเซโรโทนินจะยับยั้ง สังเกตการณ์เช่นนี้เข้ากับความสัมพันธ์ของยาแก้ซึมเศร้าที่เพิ่มการสื่อประสาทแบบเซโรโทนินกับความผิดปกติทางเพศ<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">&#91;</span>44<span class="cite-bracket">&#93;</span></a></sup> </p><p>มียา non-SSRI จำนวนหนึ่งที่ไม่สัมพันธ์กับผลข้างเคียงทางเพศ เช่น bupropion, mirtazapine, tianeptine, agomelatine, และ moclobemide<sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">&#91;</span>45<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">&#91;</span>46<span class="cite-bracket">&#93;</span></a></sup> </p><p>ไม่มีการรักษาที่รับอนุมัติจาก FDA สำหรับความผิดปกติทางเพศที่เกิดจากยา SSRI และก็ไม่มีงานศึกษาแบบสุ่ม มีกลุ่มควบคุม แบบอำพรางสองด้าน ในการรักษาที่พอเป็นไปได้<sup class="noprint Inline-Template" style="white-space:nowrap;">&#91;<i><a href="/w/index.php?title=%E0%B8%A7%E0%B8%B4%E0%B8%81%E0%B8%B4%E0%B8%9E%E0%B8%B5%E0%B9%80%E0%B8%94%E0%B8%B5%E0%B8%A2:Please_clarify&amp;action=edit&amp;redlink=1" class="new" title="วิกิพีเดีย:Please clarify (ไม่มีหน้านี้)"><span title="เหตุผลนี้ไม่ชัดเจน (October 2015)">ทำไม?</span></a></i>&#93;</sup> แต่มีหลักฐานในกลยุทธ์การบริหารเหล่านี้คือ สำหรับการไม่ตอบสนองของอวัยวะเพศ ให้เพิ่มยา PDE5 inhibitor เช่น sildenafil สำหรับความต้องการทางเพศที่ลดลง ให้เพิ่มหรือเปลี่ยนไปใช้ bupropion และสำหรับความผิดปกติทางเพศอื่น ๆ ให้เปลี่ยนไปใช้ nefazodone<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">&#91;</span>47<span class="cite-bracket">&#93;</span></a></sup> </p><p>มีงานศึกษาขนาดเล็กหลายงานที่แสดงว่า ยา SSRIs อาจมีผลลบต่อคุณภาพของ<a href="/wiki/%E0%B8%99%E0%B9%89%E0%B8%B3%E0%B8%AD%E0%B8%AA%E0%B8%B8%E0%B8%88%E0%B8%B4" title="น้ำอสุจิ">น้ำอสุจิ</a><sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">&#91;</span>48<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="หัวใจ"><span id=".E0.B8.AB.E0.B8.B1.E0.B8.A7.E0.B9.83.E0.B8.88"></span>หัวใจ</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=10" title="แก้ไขส่วน: หัวใจ"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs ไม่ปรากฏว่ามีผลต่อความเสี่ยงของโรคหัวใจขาดเลือด (CHD) ในบุคคลที่ไม่เคยได้วินิจฉัยว่ามี CHD<sup id="cite_ref-ohSWmeta2014_49-0" class="reference"><a href="#cite_note-ohSWmeta2014-49"><span class="cite-bracket">&#91;</span>49<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A8%E0%B8%B6%E0%B8%81%E0%B8%A9%E0%B8%B2%E0%B8%95%E0%B8%B2%E0%B8%A1%E0%B8%A3%E0%B8%B8%E0%B9%88%E0%B8%99" class="mw-redirect" title="งานศึกษาตามรุ่น">งานศึกษาตามรุ่น</a>ขนาดใหญ่ แสดงว่า ไม่มีความเสี่ยงต่อการเกิดหัวใจผิดปกติของทารกในครรภ์เหตุการใช้ SSRI ในไตรมาสแรกของการมีครรภ์<sup id="cite_ref-HuybrechtsPalmsten2014_50-0" class="reference"><a href="#cite_note-HuybrechtsPalmsten2014-50"><span class="cite-bracket">&#91;</span>50<span class="cite-bracket">&#93;</span></a></sup> งานศึกษาขนาดใหญ่จำนวนหนึ่งในบุคคลที่ไม่รู้ว่ามีโรคหัวใจล่วงหน้ารายงานว่า ไม่มีความเปลี่ยนแปลงทาง<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%95%E0%B8%A3%E0%B8%A7%E0%B8%88%E0%B8%84%E0%B8%A5%E0%B8%B7%E0%B9%88%E0%B8%99%E0%B9%84%E0%B8%9F%E0%B8%9F%E0%B9%89%E0%B8%B2%E0%B8%AB%E0%B8%B1%E0%B8%A7%E0%B9%83%E0%B8%88" class="mw-redirect" title="การตรวจคลื่นไฟฟ้าหัวใจ">คลื่นไฟฟ้าหัวใจ</a> (EKG) ที่เกี่ยวกับการใช้ SSRI<sup id="cite_ref-afpssri_51-0" class="reference"><a href="#cite_note-afpssri-51"><span class="cite-bracket">&#91;</span>51<span class="cite-bracket">&#93;</span></a></sup> แต่ว่า ขนาดมากที่สุดต่อวันที่แนะนำสำหรับ citalopram และ escitalopram ได้ลดลงเพราะประเด็นเรื่อง<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%A2%E0%B8%B0_QT" class="mw-redirect" title="ระยะ QT">ระยะ QT</a> ที่ยาวขึ้นของคลื่นหัวใจ<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">&#91;</span>52<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-53" class="reference"><a href="#cite_note-53"><span class="cite-bracket">&#91;</span>53<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">&#91;</span>54<span class="cite-bracket">&#93;</span></a></sup> เมื่อใช้ยาเกินขนาด มีรายงานว่า<a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>เป็นเหตุต่ออัตราหัวใจเต้นเร็วเหตุปุ่มไซนัส (sinus tachycardia), <a href="/wiki/%E0%B8%81%E0%B8%A5%E0%B9%89%E0%B8%B2%E0%B8%A1%E0%B9%80%E0%B8%99%E0%B8%B7%E0%B9%89%E0%B8%AD%E0%B8%AB%E0%B8%B1%E0%B8%A7%E0%B9%83%E0%B8%88%E0%B8%95%E0%B8%B2%E0%B8%A2%E0%B9%80%E0%B8%AB%E0%B8%95%E0%B8%B8%E0%B8%82%E0%B8%B2%E0%B8%94%E0%B9%80%E0%B8%A5%E0%B8%B7%E0%B8%AD%E0%B8%94" title="กล้ามเนื้อหัวใจตายเหตุขาดเลือด">กล้ามเนื้อหัวใจตายเหตุขาดเลือด</a>, Junctional rhythm (จังหวะหัวใจเต้นผิดปกติเหตุคลื่นจากจุดต่อระหว่าง atria กับ ventricle), และ trigeminy ผู้เขียนบางท่านเสนอให้ดูแลตรวจสอบด้วย<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%95%E0%B8%A3%E0%B8%A7%E0%B8%88%E0%B8%84%E0%B8%A5%E0%B8%B7%E0%B9%88%E0%B8%99%E0%B9%84%E0%B8%9F%E0%B8%9F%E0%B9%89%E0%B8%B2%E0%B8%AB%E0%B8%B1%E0%B8%A7%E0%B9%83%E0%B8%88" class="mw-redirect" title="การตรวจคลื่นไฟฟ้าหัวใจ">การตรวจคลื่นไฟฟ้าหัวใจ</a>สำหรับคนไข้ที่มีปัญหาโรคหัวใจรุนแรงอยู่แล้วถ้าทาน SSRIs<sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">&#91;</span>55<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="เลือดออก"><span id=".E0.B9.80.E0.B8.A5.E0.B8.B7.E0.B8.AD.E0.B8.94.E0.B8.AD.E0.B8.AD.E0.B8.81"></span>เลือดออก</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=11" title="แก้ไขส่วน: เลือดออก"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs มีปฏิสัมพันธ์กับสารกันเลือดเป็นลิ่ม (anticoagulants) เช่น <a href="/wiki/%E0%B8%A7%E0%B8%B2%E0%B8%A3%E0%B9%8C%E0%B8%9F%E0%B8%B2%E0%B8%A3%E0%B8%B4%E0%B8%99" title="วาร์ฟาริน">วาร์ฟาริน</a>และ<a href="/wiki/%E0%B9%81%E0%B8%AD%E0%B8%AA%E0%B9%84%E0%B8%9E%E0%B8%A3%E0%B8%B4%E0%B8%99" title="แอสไพริน">แอสไพริน</a><sup id="cite_ref-Wein2005_56-0" class="reference"><a href="#cite_note-Wein2005-56"><span class="cite-bracket">&#91;</span>56<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Maudsley_57-0" class="reference"><a href="#cite_note-Maudsley-57"><span class="cite-bracket">&#91;</span>57<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid21190637_58-0" class="reference"><a href="#cite_note-pmid21190637-58"><span class="cite-bracket">&#91;</span>58<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-NSAIDs_59-0" class="reference"><a href="#cite_note-NSAIDs-59"><span class="cite-bracket">&#91;</span>59<span class="cite-bracket">&#93;</span></a></sup> ซึ่งเพิ่มความเสี่ยงต่อการ<a href="/wiki/%E0%B9%80%E0%B8%A5%E0%B8%B7%E0%B8%AD%E0%B8%94%E0%B8%AD%E0%B8%AD%E0%B8%81%E0%B9%83%E0%B8%99%E0%B8%81%E0%B8%A3%E0%B8%B0%E0%B9%80%E0%B8%9E%E0%B8%B2%E0%B8%B0%E0%B8%AD%E0%B8%B2%E0%B8%AB%E0%B8%B2%E0%B8%A3%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A5%E0%B8%B3%E0%B9%84%E0%B8%AA%E0%B9%89" class="mw-redirect" title="เลือดออกในกระเพาะอาหารและลำไส้">เลือดออกในกระเพาะอาหารและลำไส้</a> และเลือดออกหลังการผ่าตัด<sup id="cite_ref-Wein2005_56-1" class="reference"><a href="#cite_note-Wein2005-56"><span class="cite-bracket">&#91;</span>56<span class="cite-bracket">&#93;</span></a></sup> แม้ว่า<a href="/wiki/%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B9%80%E0%B8%AA%E0%B8%B5%E0%B9%88%E0%B8%A2%E0%B8%87%E0%B8%AA%E0%B8%B1%E0%B8%A1%E0%B8%9E%E0%B8%B1%E0%B8%97%E0%B8%98%E0%B9%8C" title="ความเสี่ยงสัมพัทธ์">ความเสี่ยงสัมพัทธ์</a>ของเลือดออกในกะโหลกศีรษะจะเพิ่มขึ้น แต่ความเสี่ยงสัมบูรณ์นั้นต่ำมาก<sup id="cite_ref-pmid23077009_60-0" class="reference"><a href="#cite_note-pmid23077009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> </p><p>มีหลักฐานว่า SSRIs เป็นเหตุต่อการทำงานผิดปกติของ<a href="/wiki/%E0%B9%80%E0%B8%81%E0%B8%A5%E0%B9%87%E0%B8%94%E0%B9%80%E0%B8%A5%E0%B8%B7%E0%B8%AD%E0%B8%94" title="เกล็ดเลือด">เกล็ดเลือด</a><sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">&#91;</span>61<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">&#91;</span>62<span class="cite-bracket">&#93;</span></a></sup> โดยความเสี่ยงจะสูงกว่าในบุคคลที่ทานยากันเลือดเป็นลิ่ม ยาต้านเกล็ดเลือด (antiplatelet agent) และ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%AD%E0%B8%B1%E0%B8%81%E0%B9%80%E0%B8%AA%E0%B8%9A%E0%B8%8A%E0%B8%99%E0%B8%B4%E0%B8%94%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B9%83%E0%B8%8A%E0%B9%88%E0%B8%AA%E0%B9%80%E0%B8%95%E0%B8%AD%E0%B8%A3%E0%B8%AD%E0%B8%A2%E0%B8%94%E0%B9%8C" title="ยาแก้อักเสบชนิดไม่ใช่สเตอรอยด์">ยาแก้อักเสบชนิดไม่ใช่สเตอรอยด์</a> (NSAID) และในบุคคลที่มีโรคที่เป็นเหตุผิดปกติอื่น ๆ เช่น <a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%95%E0%B8%B1%E0%B8%9A%E0%B9%81%E0%B8%82%E0%B9%87%E0%B8%87" title="โรคตับแข็ง">โรคตับแข็ง</a> หรือ<a href="/wiki/%E0%B8%95%E0%B8%B1%E0%B8%9A%E0%B8%A7%E0%B8%B2%E0%B8%A2" title="ตับวาย">ตับวาย</a><sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">&#91;</span>63<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-64" class="reference"><a href="#cite_note-64"><span class="cite-bracket">&#91;</span>64<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="อาการหยุดยา_(Discontinuation_syndrome)"><span id=".E0.B8.AD.E0.B8.B2.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.AB.E0.B8.A2.E0.B8.B8.E0.B8.94.E0.B8.A2.E0.B8.B2_.28Discontinuation_syndrome.29"></span>อาการหยุดยา (Discontinuation syndrome)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=12" title="แก้ไขส่วน: อาการหยุดยา (Discontinuation syndrome)"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r9751016"><div role="note" class="hatnote navigation-not-searchable">บทความหลัก: <a href="/wiki/%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%AB%E0%B8%A2%E0%B8%B8%E0%B8%94%E0%B8%A2%E0%B8%B2%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="กลุ่มอาการหยุดยาแก้ซึมเศร้า">กลุ่มอาการหยุดยาแก้ซึมเศร้า</a></div> <p>SSRIs ไม่ควรหยุดกะทันหันหลังจากการใช้ระยะยาว และถ้าเป็นไปได้ ควรจะค่อย ๆ ลดยาเป็นระยะเวลาหลายอาทิตย์เพื่อกันอาการเกี่ยวกับการหยุดยา ซึ่งอาจรวมความคลื่นไส้ <a href="/wiki/%E0%B8%9B%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%B1%E0%B8%A7" class="mw-redirect" title="ปวดหัว">ปวดหัว</a> เวียนหัว หนาว ปวดทางกาย ความรู้สึกสัมผัสเพี้ยน <a href="/wiki/%E0%B8%99%E0%B8%AD%E0%B8%99%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B8%AB%E0%B8%A5%E0%B8%B1%E0%B8%9A" class="mw-redirect" title="นอนไม่หลับ">นอนไม่หลับ</a> และรู้สึกเหมือนถูกไฟช็อต Paroxetine อาจก่ออาการหยุดยาในอัตราที่สูงกว่ายา SSRIs อย่างอื่น ๆ แม้ว่าจะมีอาการคล้าย ๆ กันในยา SSRIs ทั้งหมด<sup id="cite_ref-psychiatryonline.org_65-0" class="reference"><a href="#cite_note-psychiatryonline.org-65"><span class="cite-bracket">&#91;</span>65<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-66" class="reference"><a href="#cite_note-66"><span class="cite-bracket">&#91;</span>66<span class="cite-bracket">&#93;</span></a></sup> แต่ผลการหยุดยาดูเหมือนจะมีน้อยกว่าสำหรับฟลูอ๊อกซิติน ซึ่งอาจเป็นเพราะระยะ<a href="/wiki/%E0%B8%84%E0%B8%A3%E0%B8%B6%E0%B9%88%E0%B8%87%E0%B8%8A%E0%B8%B5%E0%B8%A7%E0%B8%B4%E0%B8%95" title="ครึ่งชีวิต">ครึ่งชีวิต</a>ที่ยาวนานของยา และผลการค่อย ๆ ลดยาโดยธรรมชาติที่สัมพันธ์กับการกำจัดยาจากกายได้ช้า กลยุทธ์อย่างหนึ่งเพื่อป้องกันอาการหยุดยา SSRI ก็คือให้เปลี่ยนไปทานฟลูอ๊อกซิตินแล้วลดและเลิกยา<sup id="cite_ref-psychiatryonline.org_65-1" class="reference"><a href="#cite_note-psychiatryonline.org-65"><span class="cite-bracket">&#91;</span>65<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="ความเสี่ยงฆ่าตัวตาย"><span id=".E0.B8.84.E0.B8.A7.E0.B8.B2.E0.B8.A1.E0.B9.80.E0.B8.AA.E0.B8.B5.E0.B9.88.E0.B8.A2.E0.B8.87.E0.B8.86.E0.B9.88.E0.B8.B2.E0.B8.95.E0.B8.B1.E0.B8.A7.E0.B8.95.E0.B8.B2.E0.B8.A2"></span>ความเสี่ยงฆ่าตัวตาย</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=13" title="แก้ไขส่วน: ความเสี่ยงฆ่าตัวตาย"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading4"><h4 id="เด็กและวัยรุ่น"><span id=".E0.B9.80.E0.B8.94.E0.B9.87.E0.B8.81.E0.B9.81.E0.B8.A5.E0.B8.B0.E0.B8.A7.E0.B8.B1.E0.B8.A2.E0.B8.A3.E0.B8.B8.E0.B9.88.E0.B8.99"></span>เด็กและวัยรุ่น</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=14" title="แก้ไขส่วน: เด็กและวัยรุ่น"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ในงานทดลองทางคลินิกที่สุ่มคนไข้พบว่า การใช้ SSRI สัมพันธ์กับความเสี่ยงพฤติกรรมฆ่าตัวตายที่สูงกว่าในเด็กและวัยรุ่น<sup id="cite_ref-FDA2_67-0" class="reference"><a href="#cite_note-FDA2-67"><span class="cite-bracket">&#91;</span>67<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-FDA3_68-0" class="reference"><a href="#cite_note-FDA3-68"><span class="cite-bracket">&#91;</span>68<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Olfson_69-0" class="reference"><a href="#cite_note-Olfson-69"><span class="cite-bracket">&#91;</span>69<span class="cite-bracket">&#93;</span></a></sup> ยกตัวอย่างเช่น งานวิเคราะห์ปี 2547 ของ FDA ในงานทดลองทางคลินิกกับเด็กที่มี<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%8B%E0%B8%B6%E0%B8%A1%E0%B9%80%E0%B8%A8%E0%B8%A3%E0%B9%89%E0%B8%B2" title="โรคซึมเศร้า">โรคซึมเศร้า</a> (MDD) พบการเพิ่มขึ้นที่มี<a href="/wiki/%E0%B8%99%E0%B8%B1%E0%B8%A2%E0%B8%AA%E0%B8%B3%E0%B8%84%E0%B8%B1%E0%B8%8D%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%AA%E0%B8%96%E0%B8%B4%E0%B8%95%E0%B8%B4" title="นัยสำคัญทางสถิติ">นัยสำคัญทางสถิติ</a>ของ "ความคิดและพฤติกรรมฆ่าตัวตาย" โดยประมาณ 80% และความกระวนกระวายและความเป็นปรปักษ์ประมาณ 130%<sup id="cite_ref-FDA_70-0" class="reference"><a href="#cite_note-FDA-70"><span class="cite-bracket">&#91;</span>70<span class="cite-bracket">&#93;</span></a></sup> ตามข้อมูลของ FDA ความเสี่ยงเกี่ยวกับการฆ่าตัวตายที่สูงขึ้นจะมีภายใน 1-2 เดือนที่เริ่มการรักษา<sup id="cite_ref-71" class="reference"><a href="#cite_note-71"><span class="cite-bracket">&#91;</span>71<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-72" class="reference"><a href="#cite_note-72"><span class="cite-bracket">&#91;</span>72<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid23152255_73-0" class="reference"><a href="#cite_note-pmid23152255-73"><span class="cite-bracket">&#91;</span>73<span class="cite-bracket">&#93;</span></a></sup> ส่วน NICE แสดงว่าความเสี่ยงที่สูงขึ้นอยู่ใน "ระยะต้น ๆ ของการรักษา"<sup id="cite_ref-74" class="reference"><a href="#cite_note-74"><span class="cite-bracket">&#91;</span>74<span class="cite-bracket">&#93;</span></a></sup> และสมาคมจิตเวชยุโรป (EPA) แสดงว่าความเสี่ยงที่สูงขึ้นอยู่ในช่วง 2 สัปดาห์แรก และว่า โดยอาศัยข้อมูล<a href="/wiki/%E0%B8%A7%E0%B8%B4%E0%B8%97%E0%B8%A2%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%B2%E0%B8%94" title="วิทยาการระบาด">วิทยาการระบาด</a> <a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A8%E0%B8%B6%E0%B8%81%E0%B8%A9%E0%B8%B2%E0%B8%95%E0%B8%B2%E0%B8%A1%E0%B8%A3%E0%B8%B8%E0%B9%88%E0%B8%99%E0%B8%95%E0%B8%B2%E0%B8%A1%E0%B9%81%E0%B8%9C%E0%B8%99" title="งานศึกษาตามรุ่นตามแผน">งานศึกษาตามรุ่นตามแผน</a> เคลมประกันสุขภาพ และ<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%97%E0%B8%94%E0%B8%A5%E0%B8%AD%E0%B8%87%E0%B9%81%E0%B8%9A%E0%B8%9A%E0%B8%AA%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A1%E0%B8%B5%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%84%E0%B8%A7%E0%B8%9A%E0%B8%84%E0%B8%B8%E0%B8%A1" title="การทดลองแบบสุ่มและมีกลุ่มควบคุม">การทดลองทางคลินิกแบบสุ่ม</a> สามารถสรุปว่า ผลป้องกันจะมีมากกว่าหลังจากระยะต้น ๆ แต่ว่า<a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%97%E0%B8%9A%E0%B8%97%E0%B8%A7%E0%B8%99%E0%B8%A7%E0%B8%A3%E0%B8%A3%E0%B8%93%E0%B8%81%E0%B8%A3%E0%B8%A3%E0%B8%A1" class="mw-redirect" title="งานทบทวนวรรณกรรม">งานทบทวนวรรณกรรม</a>แบบคอเครนปี 2555 พบว่า ในระยะระหว่าง 6-9 เดือน ความคิดฆ่าตัวตายในเด็กที่รักษาด้วยยาแก้ซึมเศร้าก็ยังสูงกว่าที่รักษาด้วยการบำบัดทางจิต<sup id="cite_ref-75" class="reference"><a href="#cite_note-75"><span class="cite-bracket">&#91;</span>75<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ปี 2550 ที่เปรียบเทียบความก้าวร้าวและความเป็นปรปักษ์ที่เกิดขึ้นเมื่อรักษาด้วย<a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>เทียบกับ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%81" title="ยาหลอก">ยาหลอก</a>ในเด็กและวัยรุ่นพบว่า ไม่มีความแตกต่างกันอย่างสำคัญ<sup id="cite_ref-76" class="reference"><a href="#cite_note-76"><span class="cite-bracket">&#91;</span>76<span class="cite-bracket">&#93;</span></a></sup> มีหลักฐานด้วยว่า อัตราการจ่ายยา SSRI ที่สูงกว่าสัมพันธ์กับอัตราการฆ่าตัวตายในเด็ก แม้ว่าหลักฐานจะเป็นแบบแสดง<a href="/wiki/%E0%B8%AA%E0%B8%AB%E0%B8%AA%E0%B8%B1%E0%B8%A1%E0%B8%9E%E0%B8%B1%E0%B8%99%E0%B8%98%E0%B9%8C" title="สหสัมพันธ์">สหสัมพันธ์</a> ดังนั้น เหตุจริง ๆ ก็ยังไม่ชัดเจน<sup id="cite_ref-pmid17074941_77-0" class="reference"><a href="#cite_note-pmid17074941-77"><span class="cite-bracket">&#91;</span>77<span class="cite-bracket">&#93;</span></a></sup> </p><p>ในปี 2547 องค์การควบคุมผลิตภัณฑ์ยาและสุขภาพของสหราชอาณาจักร (Medicines and Healthcare products Regulatory ตัวย่อ MHRA) ชี้ขาดว่า <a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a>เป็นยาแก้ซึมเศร้าอย่างเดียวที่อัตราความเสี่ยง-ประโยชน์ที่ได้ดีกับเด็กซึมเศร้า แม้ว่า จะสัมพันธ์กับความเสี่ยงที่สูงขึ้นเล็กน้อยในการทำร้ายตัวเองและความคิดฆ่าตัวตาย<sup id="cite_ref-78" class="reference"><a href="#cite_note-78"><span class="cite-bracket">&#91;</span>78<span class="cite-bracket">&#93;</span></a></sup> แต่ว่า มี SSRIs 2 อย่างเท่านั้นที่อนุมัติให้ใช้กับเด็กในสหราชอาณาจักร คือ sertraline กับ fluvoxamine และเพื่อรักษา<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%84%E0%B8%B4%E0%B8%94%E0%B8%A2%E0%B9%89%E0%B8%B3%E0%B8%97%E0%B8%B3" title="โรคย้ำคิดย้ำทำ">โรคย้ำคิดย้ำทำ</a> (OCD) เท่านั้น และฟลูอ๊อกซิตินไม่ได้รับอนุมัติให้ใช้กับเด็กโดยประการทั้งปวง<sup id="cite_ref-MHRAoverview_79-0" class="reference"><a href="#cite_note-MHRAoverview-79"><span class="cite-bracket">&#91;</span>79<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="ผู้ใหญ่"><span id=".E0.B8.9C.E0.B8.B9.E0.B9.89.E0.B9.83.E0.B8.AB.E0.B8.8D.E0.B9.88"></span>ผู้ใหญ่</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=15" title="แก้ไขส่วน: ผู้ใหญ่"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ไม่ชัดเจนว่า SSRIs มีผลต่อความเสี่ยงพฤติกรรมฆ่าตัวตายของผู้ใหญ่หรือไม่ </p> <ul><li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ปี 2549 ที่ทำโดยบริษัทยาไม่พบหลักฐานว่า SSRIs เพิ่มความเสี่ยงฆ่าตัวตาย แต่ว่า งานไม่ได้กันผลป้องกันหรือผลอันตรายอื่น ๆ ที่อาจมี<sup id="cite_ref-80" class="reference"><a href="#cite_note-80"><span class="cite-bracket">&#91;</span>80<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%9B%E0%B8%A3%E0%B8%B4%E0%B8%97%E0%B8%B1%E0%B8%A8%E0%B8%99%E0%B9%8C%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A" class="mw-redirect" title="งานปริทัศน์เป็นระบบ">งานปริทัศน์เป็นระบบ</a>ปี 2549 ให้ข้อสังเกตว่า การพยายามฆ่าตัวตายเพิ่มขึ้นในคนที่ใช้ยา SSRIs เทียบกับ<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B8%AB%E0%B8%A5%E0%B8%AD%E0%B8%81" title="ยาหลอก">ยาหลอก</a> และเทียบกับการแทรกแซงรักษาอื่น ๆ นอกจากยาแก้ซึมเศร้าแบบ tricyclic</li></ul> <p>ยา SSRIs และยาแก้ซึมเศร้าแบบ tricyclic ไม่มีผลต่างกันต่อความเสี่ยงพยายามฆ่าตัวตาย<sup id="cite_ref-81" class="reference"><a href="#cite_note-81"><span class="cite-bracket">&#91;</span>81<span class="cite-bracket">&#93;</span></a></sup> </p> <ul><li>โดยเปรียบเทียบกัน งานทบทวนวรรณกรรมปี 2549 แสดงว่า การใช้ยาแก้ซึมเศร้าอย่างกว้างขวางทั่วไปใน "ยุค SSRI" ใหม่นี้ ดูเหมือนจะลดอัตราการฆ่าตัวตายอย่างสำคัญยิ่งในประเทศโดยมากที่ธรรมดามีอัตราพื้นฐานการฆ่าตัวตายสูง โดยเฉพาะอย่างยิ่งในหญิง ซึ่งเมื่อเทียบกับชาย จะหาความช่วยเหลือมากกว่าเมื่อเกิดความซึมเศร้า ข้อมูลคลินิกปี 2549 ที่มีขนาดตัวอย่างขนาดใหญ่ใน<a href="/wiki/%E0%B8%AA%E0%B8%AB%E0%B8%A3%E0%B8%B1%E0%B8%90%E0%B8%AD%E0%B9%80%E0%B8%A1%E0%B8%A3%E0%B8%B4%E0%B8%81%E0%B8%B2" title="สหรัฐอเมริกา">สหรัฐอเมริกา</a> ก็แสดงผลป้องกันของยาแก้ซึมเศร้าต่อการฆ่าตัวตายด้วย<sup id="cite_ref-82" class="reference"><a href="#cite_note-82"><span class="cite-bracket">&#91;</span>82<span class="cite-bracket">&#93;</span></a></sup></li> <li>งานวิเคราะห์อภิมานปี 2549 ของ<a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%97%E0%B8%94%E0%B8%A5%E0%B8%AD%E0%B8%87%E0%B9%81%E0%B8%9A%E0%B8%9A%E0%B8%AA%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A1%E0%B8%B5%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%84%E0%B8%A7%E0%B8%9A%E0%B8%84%E0%B8%B8%E0%B8%A1" class="mw-redirect" title="งานทดลองแบบสุ่มและมีกลุ่มควบคุม">งานทดลองแบบสุ่มและมีกลุ่มควบคุม</a>แสดงว่า SSRIs เพิ่มความคิดฆ่าตัวตายเทียบกับยาหลอก แต่ว่า ก็ยังมี<a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A8%E0%B8%B6%E0%B8%81%E0%B8%A9%E0%B8%B2%E0%B9%81%E0%B8%9A%E0%B8%9A%E0%B8%AA%E0%B8%B1%E0%B8%87%E0%B9%80%E0%B8%81%E0%B8%95" title="งานศึกษาแบบสังเกต">งานศึกษาแบบสังเกต</a>ที่แสดงว่า SSRIs ไม่ได้เพิ่มความเสี่ยงฆ่าตัวตายมากกว่ายาแก้ซึมเศร้าที่เก่ากว่า นักวิจัยอ้างว่า แม้ SSRIs จะเพิ่มความเสี่ยงฆ่าตัวตายในคนไข้บางพวก แต่จำนวนความตายที่เพิ่มก็น้อยมากโดย<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A8%E0%B8%B6%E0%B8%81%E0%B8%A9%E0%B8%B2%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%99%E0%B8%B4%E0%B9%80%E0%B8%A7%E0%B8%A8%E0%B8%A7%E0%B8%B4%E0%B8%97%E0%B8%A2%E0%B8%B2" title="การศึกษาทางนิเวศวิทยา">การศึกษาทางนิเวศวิทยา</a>ทั่วไปได้พบว่า อัตราการตายจากการฆ่าตัวตายได้ลดลง (หรืออย่างน้อยก็ไม่ได้เพิ่ม) ในขณะที่การใช้ SSRIs ได้เพิ่มขึ้น<sup id="cite_ref-83" class="reference"><a href="#cite_note-83"><span class="cite-bracket">&#91;</span>83<span class="cite-bracket">&#93;</span></a></sup></li> <li><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>อีกงานหนึ่งของ FDA ปี 2549 พบผลของ SSRI ที่เกี่ยวกับอายุ คือ ในบรรดาบุคคลอายุน้อยกว่า 25 ปี มีความเสี่ยงพฤติกรรมฆ่าตัวตายที่สูงขึ้น สำหรับผู้ใหญ่ระหว่าง 25-64 ปี มีผลป้องกันในระดับพอประมาณ และสำหรับผู้ใหญ่อายุเกิน 64 มีผลป้องกันในระดับสูงกว่า<sup id="cite_ref-FDA2_67-1" class="reference"><a href="#cite_note-FDA2-67"><span class="cite-bracket">&#91;</span>67<span class="cite-bracket">&#93;</span></a></sup><sup class="reference nowrap"><span title="Page / location: 27">&#58;&#8202;27&#8202;</span></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="การตั้งครรภ์และการเลี้ยงลูกด้วยนม"><span id=".E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.95.E0.B8.B1.E0.B9.89.E0.B8.87.E0.B8.84.E0.B8.A3.E0.B8.A3.E0.B8.A0.E0.B9.8C.E0.B9.81.E0.B8.A5.E0.B8.B0.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B9.80.E0.B8.A5.E0.B8.B5.E0.B9.89.E0.B8.A2.E0.B8.87.E0.B8.A5.E0.B8.B9.E0.B8.81.E0.B8.94.E0.B9.89.E0.B8.A7.E0.B8.A2.E0.B8.99.E0.B8.A1"></span>การตั้งครรภ์และการเลี้ยงลูกด้วยนม</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=16" title="แก้ไขส่วน: การตั้งครรภ์และการเลี้ยงลูกด้วยนม"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>การใช้ SSRI ระหว่างมีครรภ์สัมพันธ์กับความเสี่ยงต่าง ๆ โดยมีหลักฐานแบบแสดงเหตุจากยาที่มีน้ำหนักต่าง ๆ กัน เนื่องจากความซึมเศร้าสัมพันธ์อย่างเป็นอิสระกับผลลบที่เกิดจากการตั้งครรภ์ การกำหนดยาแก้ซึมเศร้าที่สัมพันธ์โดยเป็นเหตุกับ<a href="/wiki/%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B8%9E%E0%B8%B6%E0%B8%87%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%87%E0%B8%84%E0%B9%8C%E0%B8%88%E0%B8%B2%E0%B8%81%E0%B8%A2%E0%B8%B2" title="อาการไม่พึงประสงค์จากยา">ผลที่ไม่พึงประสงค์</a>โดยเฉพาะ ๆ เป็นเรื่องยากในบางกรณี<sup id="cite_ref-84" class="reference"><a href="#cite_note-84"><span class="cite-bracket">&#91;</span>84<span class="cite-bracket">&#93;</span></a></sup> แต่ในกรณีอื่น การแสดงผลลบว่ามีเหตุจากยาดูค่อนข้างจะชัดเจน </p><p>การใช้ SSRI เมื่อมีครรภ์สัมพันธ์กับความเสี่ยงการแท้งบุตรเองที่เพิ่มขึ้นเป็น 1.7 เท่า<sup id="cite_ref-85" class="reference"><a href="#cite_note-85"><span class="cite-bracket">&#91;</span>85<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Nikfar_S,_Rahimi_R,_Hendoiee_N,_Abdollahi_M_2012_75_86-0" class="reference"><a href="#cite_note-Nikfar_S,_Rahimi_R,_Hendoiee_N,_Abdollahi_M_2012_75-86"><span class="cite-bracket">&#91;</span>86<span class="cite-bracket">&#93;</span></a></sup> แต่การใช้ SSRI ของมารดาอาจจะสัมพันธ์กับความเสี่ยงที่ต่ำกว่าต่อการคลอดบุตรก่อนกำหนด และต่อ<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%9C%E0%B9%88%E0%B8%B2%E0%B8%97%E0%B9%89%E0%B8%AD%E0%B8%87%E0%B8%97%E0%B8%B3%E0%B8%84%E0%B8%A5%E0%B8%AD%E0%B8%94" title="การผ่าท้องทำคลอด">การผ่าท้องทำคลอด</a><sup id="cite_ref-87" class="reference"><a href="#cite_note-87"><span class="cite-bracket">&#91;</span>87<span class="cite-bracket">&#93;</span></a></sup> งานปริทัศน์เป็นระบบปี 2555 ที่ตรวจความผิดปกติแต่กำเนิดที่สำคัญของทารกที่มารดาใช้ยาแก้ซึมเศร้าระหว่างตั้งครรภ์ พบความเสี่ยงที่เพิ่มขึ้นเล็กน้อย (3%-24%) ของสภาพวิรูปสำคัญ (major malformation) แต่ความเสี่ยงความผิดปกติหลอดเลือดหัวใจแต่กำเนิดไม่ต่างจากมารดาที่ไม่ได้ใช้<sup id="cite_ref-88" class="reference"><a href="#cite_note-88"><span class="cite-bracket">&#91;</span>88<span class="cite-bracket">&#93;</span></a></sup> งานศึกษาหญิงมีครรภ์ที่ใช้ฟลูอ๊อกซิตินงานหนึ่ง พบความเสี่ยงของสภาพวิรูปสำคัญเพิ่มขึ้น 12% ที่เกือบถึงขีด<a href="/wiki/%E0%B8%99%E0%B8%B1%E0%B8%A2%E0%B8%AA%E0%B8%B3%E0%B8%84%E0%B8%B1%E0%B8%8D%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%AA%E0%B8%96%E0%B8%B4%E0%B8%95%E0%B8%B4" title="นัยสำคัญทางสถิติ">นัยสำคัญทางสถิติ</a><sup id="cite_ref-89" class="reference"><a href="#cite_note-89"><span class="cite-bracket">&#91;</span>89<span class="cite-bracket">&#93;</span></a></sup> งานอื่น ๆ พบความเสี่ยงความผิดปกติหลอดเลือดหัวใจแต่กำเนิดเพิ่มขึ้นในบรรดามารดาที่ซึมเศร้าแต่ไม่ได้รักษาโดย SSRI ซึ่งแสดงว่างานต่าง ๆ อาจมีความเอนเอียงในการสุ่มตัวอย่าง คือ มารดาที่กังวลอาจจะให้ตรวจดูทารกของตนเองมากกว่า<sup id="cite_ref-90" class="reference"><a href="#cite_note-90"><span class="cite-bracket">&#91;</span>90<span class="cite-bracket">&#93;</span></a></sup> ส่วนอีกงานหนึ่งไม่พบความเสี่ยงความผิดปกติหลอดเลือดหัวใจแต่กำเนิดที่เพิ่มขึ้น แต่พบความเสี่ยงสภาพวิรูปสำคัญที่เพิ่มขึ้น 27% ในบรรดาหญิงมีครรภ์ที่ใช้ SSRI<sup id="cite_ref-Nikfar_S,_Rahimi_R,_Hendoiee_N,_Abdollahi_M_2012_75_86-1" class="reference"><a href="#cite_note-Nikfar_S,_Rahimi_R,_Hendoiee_N,_Abdollahi_M_2012_75-86"><span class="cite-bracket">&#91;</span>86<span class="cite-bracket">&#93;</span></a></sup> </p><p>FDA แถลงการณ์เมื่อปี 2549 ว่า มารดาที่ให้นมลูกอยู่และทาน SSRI ต้องปรึกษากับหมอเรื่องการรักษา แต่ว่า วรรณกรรมทางแพทย์เกี่ยวกับความปลอดภัยของ SSRIs กำหนดว่า SSRIs บางอย่างเช่น Sertraline และ Paroxetine พิจารณาว่าปลอดภัยเมื่อให้นมลูก<sup id="cite_ref-91" class="reference"><a href="#cite_note-91"><span class="cite-bracket">&#91;</span>91<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-92" class="reference"><a href="#cite_note-92"><span class="cite-bracket">&#91;</span>92<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-93" class="reference"><a href="#cite_note-93"><span class="cite-bracket">&#91;</span>93<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="อาการขาดยาของทารกเกิดใหม่"><span id=".E0.B8.AD.E0.B8.B2.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.82.E0.B8.B2.E0.B8.94.E0.B8.A2.E0.B8.B2.E0.B8.82.E0.B8.AD.E0.B8.87.E0.B8.97.E0.B8.B2.E0.B8.A3.E0.B8.81.E0.B9.80.E0.B8.81.E0.B8.B4.E0.B8.94.E0.B9.83.E0.B8.AB.E0.B8.A1.E0.B9.88"></span>อาการขาดยาของทารกเกิดใหม่</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=17" title="แก้ไขส่วน: อาการขาดยาของทารกเกิดใหม่"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>งานศึกษาหลายงานได้แสดงหลักฐานอาการขาดยาของทารกเกิดใหม่ (neonatal abstinence syndrome) ซึ่งเป็นอาการทาง<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="ระบบประสาท">ประสาท</a> ทาง<a href="/wiki/%E0%B8%81%E0%B8%A3%E0%B8%B0%E0%B9%80%E0%B8%9E%E0%B8%B2%E0%B8%B0%E0%B8%AD%E0%B8%B2%E0%B8%AB%E0%B8%B2%E0%B8%A3" title="กระเพาะอาหาร">กระเพาะ</a>และ<a href="/wiki/%E0%B8%A5%E0%B8%B3%E0%B9%84%E0%B8%AA%E0%B9%89" title="ลำไส้">ลำไส้</a> ทาง<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97%E0%B8%AD%E0%B8%B1%E0%B8%95%E0%B9%82%E0%B8%99%E0%B8%A7%E0%B8%B1%E0%B8%95%E0%B8%B4" class="mw-redirect" title="ระบบประสาทอัตโนวัติ">ระบบประสาทอัตโนวัติ</a> ทาง<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A%E0%B8%95%E0%B9%88%E0%B8%AD%E0%B8%A1%E0%B9%84%E0%B8%A3%E0%B9%89%E0%B8%97%E0%B9%88%E0%B8%AD" title="ระบบต่อมไร้ท่อ">ระบบต่อมไร้ท่อ</a> และทาง<a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%AB%E0%B8%B2%E0%B8%A2%E0%B9%83%E0%B8%88" title="การหายใจ">การหายใจ</a>ในทารกส่วนน้อยแต่เป็นจำนวนมากที่มารดาใช้ยา SSRI เมื่ออยู่ในครรภ์ อาการเหล่านี้เป็นแค่สั้น ๆ แต่ก็ยังไม่มีข้อมูลเพียงพอที่จะกำหนดว่ามีผลระยะยาวอะไรหรือไม่<sup id="cite_ref-94" class="reference"><a href="#cite_note-94"><span class="cite-bracket">&#91;</span>94<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-95" class="reference"><a href="#cite_note-95"><span class="cite-bracket">&#91;</span>95<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด"><span id=".E0.B8.84.E0.B8.A7.E0.B8.B2.E0.B8.A1.E0.B8.94.E0.B8.B1.E0.B8.99.E0.B9.82.E0.B8.A5.E0.B8.AB.E0.B8.B4.E0.B8.95.E0.B9.83.E0.B8.99.E0.B8.9B.E0.B8.AD.E0.B8.94.E0.B8.AA.E0.B8.B9.E0.B8.87.E0.B8.A2.E0.B8.B1.E0.B8.87.E0.B8.84.E0.B8.87.E0.B8.AD.E0.B8.A2.E0.B8.B9.E0.B9.88.E0.B9.83.E0.B8.99.E0.B8.97.E0.B8.B2.E0.B8.A3.E0.B8.81.E0.B9.81.E0.B8.A3.E0.B8.81.E0.B9.80.E0.B8.81.E0.B8.B4.E0.B8.94"></span>ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=18" title="แก้ไขส่วน: ความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิด"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/%E0%B8%84%E0%B8%A7%E0%B8%B2%E0%B8%A1%E0%B8%94%E0%B8%B1%E0%B8%99%E0%B9%82%E0%B8%A5%E0%B8%AB%E0%B8%B4%E0%B8%95%E0%B9%83%E0%B8%99%E0%B8%9B%E0%B8%AD%E0%B8%94%E0%B8%AA%E0%B8%B9%E0%B8%87" title="ความดันโลหิตในปอดสูง">ความดันโลหิตในปอดสูง</a>ยังคงอยู่ในทารกแรกเกิด (PPHN) เป็นความผิดปกติของปอดที่มีน้อยมากแต่รุนแรงและอาจถึงชีวิตได้ ที่เกิดขึ้นหลังจากทารกเพิ่งคลอด ทารก PPHN จะมีความดันสูงในหลอดเลือดในปอดและไม่สามารถได้<a href="/wiki/%E0%B8%AD%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B9%80%E0%B8%88%E0%B8%99" title="ออกซิเจน">ออกซิเจน</a>เข้าไปในเลือดพอ ในสหรัฐอเมริกา มีทารก 1-2 คนต่อ 1,000 คนที่เกิด PPHN ไม่นานหลังจากเกิด และบ่อยครั้งต้องได้การดูแลรักษาอย่างเข้ม และสัมพันธ์กับความเสี่ยงต่อความบกพร่องทางประสาทระยะยาวที่เพิ่มขึ้น 25%<sup id="cite_ref-96" class="reference"><a href="#cite_note-96"><span class="cite-bracket">&#91;</span>96<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A7%E0%B8%B4%E0%B9%80%E0%B8%84%E0%B8%A3%E0%B8%B2%E0%B8%B0%E0%B8%AB%E0%B9%8C%E0%B8%AD%E0%B8%A0%E0%B8%B4%E0%B8%A1%E0%B8%B2%E0%B8%99" class="mw-redirect" title="งานวิเคราะห์อภิมาน">งานวิเคราะห์อภิมาน</a>ปี 2557 ไม่พบความเสี่ยงเพิ่มขึ้นของความดันโลหิตในปอดสูงที่สัมพันธ์กับการใช้ยา SSRI ในการมีครรภ์ระยะต้น และความเสี่ยงที่เพิ่มขึ้นเล็กน้อยถ้าใช้ในการตั้งครรภ์ระยะปลาย "ต้องมีหญิงประมาณ 286-351 คนที่รักษาด้วย SSRI ในช่วงตั้งครรภ์ปลาย เพื่อจะได้ผลเป็นความดันโลหิตในปอดสูงยังคงอยู่ในทารกแรกเกิดเพิ่มขึ้นโดยเฉลี่ยอีก 1 ราย"<sup id="cite_ref-97" class="reference"><a href="#cite_note-97"><span class="cite-bracket">&#91;</span>97<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%9B%E0%B8%A3%E0%B8%B4%E0%B8%97%E0%B8%B1%E0%B8%A8%E0%B8%99%E0%B9%8C%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%A3%E0%B8%B0%E0%B8%9A%E0%B8%9A" class="mw-redirect" title="งานปริทัศน์เป็นระบบ">งานปริทัศน์เป็นระบบ</a>ปี 2555 มีข้อสรุปที่คล้ายกันมาก<sup id="cite_ref-98" class="reference"><a href="#cite_note-98"><span class="cite-bracket">&#91;</span>98<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="ผลทางประสาทจิตเวชต่อลูก"><span id=".E0.B8.9C.E0.B8.A5.E0.B8.97.E0.B8.B2.E0.B8.87.E0.B8.9B.E0.B8.A3.E0.B8.B0.E0.B8.AA.E0.B8.B2.E0.B8.97.E0.B8.88.E0.B8.B4.E0.B8.95.E0.B9.80.E0.B8.A7.E0.B8.8A.E0.B8.95.E0.B9.88.E0.B8.AD.E0.B8.A5.E0.B8.B9.E0.B8.81"></span>ผลทางประสาทจิตเวชต่อลูก</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=19" title="แก้ไขส่วน: ผลทางประสาทจิตเวชต่อลูก"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%97%E0%B8%9A%E0%B8%97%E0%B8%A7%E0%B8%99%E0%B8%A7%E0%B8%A3%E0%B8%A3%E0%B8%93%E0%B8%81%E0%B8%A3%E0%B8%A3%E0%B8%A1" class="mw-redirect" title="งานทบทวนวรรณกรรม">งานทบทวนวรรณกรรม</a>ปี 2558 พบว่า "มีสัญญาณที่แสดงว่า การได้ SSRIs ก่อนเกิดอาจเพิ่มความเสี่ยงต่อ ASDs (autism spectrum disorders)"<sup id="cite_ref-99" class="reference"><a href="#cite_note-99"><span class="cite-bracket">&#91;</span>99<span class="cite-bracket">&#93;</span></a></sup> แม้ว่าจะมี<a href="/wiki/%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%A8%E0%B8%B6%E0%B8%81%E0%B8%A9%E0%B8%B2%E0%B8%95%E0%B8%B2%E0%B8%A1%E0%B8%A3%E0%B8%B8%E0%B9%88%E0%B8%99" class="mw-redirect" title="งานศึกษาตามรุ่น">งานศึกษาตามรุ่น</a> (cohort) ขนาดใหญ่ที่ตีพิมพ์ในปี 2556<sup id="cite_ref-100" class="reference"><a href="#cite_note-100"><span class="cite-bracket">&#91;</span>100<span class="cite-bracket">&#93;</span></a></sup> และงานศึกษาตามรุ่นปี 2559 ที่ใช้ข้อมูลจากทะเบียนประจำชาติ<a href="/wiki/%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B9%80%E0%B8%97%E0%B8%A8%E0%B8%9F%E0%B8%B4%E0%B8%99%E0%B9%81%E0%B8%A5%E0%B8%99%E0%B8%94%E0%B9%8C" title="ประเทศฟินแลนด์">ประเทศฟินแลนด์</a>ระหว่างปี 2539-2553 ที่ทั้งสองไม่พบความสัมพันธ์ที่มีนัยสำคัญระหว่างการใช้ SSRI และ<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%AD%E0%B8%AD%E0%B8%97%E0%B8%B4%E0%B8%8B%E0%B8%B6%E0%B8%A1" title="โรคออทิซึม">โรคออทิซึม</a>ในลูก<sup id="cite_ref-Finland2016_101-0" class="reference"><a href="#cite_note-Finland2016-101"><span class="cite-bracket">&#91;</span>101<span class="cite-bracket">&#93;</span></a></sup> งานวิจัยของฟินแลนด์ยังไม่พบความสัมพันธ์กับ<a href="/wiki/%E0%B9%82%E0%B8%A3%E0%B8%84%E0%B8%AA%E0%B8%A1%E0%B8%B2%E0%B8%98%E0%B8%B4%E0%B8%AA%E0%B8%B1%E0%B9%89%E0%B8%99" class="mw-redirect" title="โรคสมาธิสั้น">โรคสมาธิสั้น</a> (ADHD) อีกด้วย แต่พบความสัมพันธ์กับอัตราการวินิจฉัยโรคซึมเศร้าที่เพิ่มขึ้นในวัยรุ่นต้น ๆ<sup id="cite_ref-Finland2016_101-1" class="reference"><a href="#cite_note-Finland2016-101"><span class="cite-bracket">&#91;</span>101<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="ยาเกินขนาด"><span id=".E0.B8.A2.E0.B8.B2.E0.B9.80.E0.B8.81.E0.B8.B4.E0.B8.99.E0.B8.82.E0.B8.99.E0.B8.B2.E0.B8.94"></span>ยาเกินขนาด</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=20" title="แก้ไขส่วน: ยาเกินขนาด"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs ดูเหมือนจะปลอดภัยเมื่อใช้เกินขนาดเปรียบเทียบกับยาแก้ซึมเศร้าที่มีมาก่อน เช่น ยาแก้ซึมเศร้าแบบ tricyclic ความปลอดภัยโดยเปรียบเทียบเช่นนี้มีหลักฐานในงานแบบ <a href="/wiki/Case_series" title="Case series">case series</a> และงานศึกษาอัตราความตายต่อใบสั่งยา<sup id="cite_ref-ClinTox2004-isbister_102-0" class="reference"><a href="#cite_note-ClinTox2004-isbister-102"><span class="cite-bracket">&#91;</span>102<span class="cite-bracket">&#93;</span></a></sup> แต่ว่า <a href="/wiki/%E0%B8%A3%E0%B8%B2%E0%B8%A2%E0%B8%87%E0%B8%B2%E0%B8%99%E0%B8%9C%E0%B8%B9%E0%B9%89%E0%B8%9B%E0%B9%88%E0%B8%A7%E0%B8%A2" title="รายงานผู้ป่วย">รายงานผู้ป่วย</a>ที่เกิด<a href="/wiki/%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99" title="กลุ่มอาการเซโรโทนิน">พิษจากยา SSRI</a> แสดงว่า ความเป็นพิษรุนแรงก็เกิดขึ้นได้เหมือนกัน<sup id="cite_ref-AmJEmergMed1992-Borys_103-0" class="reference"><a href="#cite_note-AmJEmergMed1992-Borys-103"><span class="cite-bracket">&#91;</span>103<span class="cite-bracket">&#93;</span></a></sup> และมีการรายงานความตายหลังจากทานยาทีเดียวเป็นจำนวนมาก<sup id="cite_ref-Lancet1996-Ostrom_104-0" class="reference"><a href="#cite_note-Lancet1996-Ostrom-104"><span class="cite-bracket">&#91;</span>104<span class="cite-bracket">&#93;</span></a></sup> แม้ว่านี้จะน้อยมากเทียบกับยาแก้ซึมเศร้าแบบ tricyclic<sup id="cite_ref-ClinTox2004-isbister_102-1" class="reference"><a href="#cite_note-ClinTox2004-isbister-102"><span class="cite-bracket">&#91;</span>102<span class="cite-bracket">&#93;</span></a></sup> แต่เพราะดัชนีการรักษา (therapeutic index) ที่สูงของ SSRI คนไข้โดยมากจะมีอาการอ่อนหรือไม่มีเลยถ้าใช้ยามากเกินไปแบบกลาง ๆ ผลรุนแรงที่รายงานมากที่สุดหลังกจากใช้ SSRI เกินขนาดก็คือ <a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%9E%E0%B8%B4%E0%B8%A9" class="mw-redirect" title="เซโรโทนินเป็นพิษ">เซโรโทนินเป็นพิษ</a> (serotonin syndrome) ซึ่งมักจะมาจากการใช้ยาเกินขนาดมาก ๆ หรือทานยาหลายรอบ<sup id="cite_ref-DrugSaf1995-Sporer_105-0" class="reference"><a href="#cite_note-DrugSaf1995-Sporer-105"><span class="cite-bracket">&#91;</span>105<span class="cite-bracket">&#93;</span></a></sup> ผลสำคัญที่รายงานอื่น ๆ รวมทั้ง<a href="/wiki/%E0%B9%82%E0%B8%84%E0%B8%A1%E0%B9%88%E0%B8%B2" title="โคม่า">โคม่า</a> <a href="/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%8A%E0%B8%B1%E0%B8%81" title="การชัก">การชัก</a> ความเป็นพิษต่อหัวใจ<sup id="cite_ref-ClinTox2004-isbister_102-2" class="reference"><a href="#cite_note-ClinTox2004-isbister-102"><span class="cite-bracket">&#91;</span>102<span class="cite-bracket">&#93;</span></a></sup> รายการ SSRIs ตามลำดับความเป็นพิษที่ลดลง มีดังต่อไปนี้<sup id="cite_ref-106" class="reference"><a href="#cite_note-106"><span class="cite-bracket">&#91;</span>106<span class="cite-bracket">&#93;</span></a></sup> </p> <div> <table width="100%" border="0" cellspacing="0" cellpadding="0" style="background-color:transparent;table-layout:fixed;"> <tbody><tr valign="top"> <td><div style="margin-right:20px;"> <ol><li>Citalopram (เนื่องจากโอกาส<a href="/wiki/%E0%B8%A3%E0%B8%B0%E0%B8%A2%E0%B8%B0_QT" class="mw-redirect" title="ระยะ QT">ระยะ QT</a> ที่ยาวขึ้นของคลื่นหัวใจ)</li> <li>Fluvoxamine</li> <li>Escitalopram</li></ol> </div> </td> <td><div style="margin-right: 20px;"> <ol><li>Paroxetine</li> <li>Sertraline</li> <li><a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a></li></ol> </div> </td></tr></tbody></table></div> <div class="mw-heading mw-heading2"><h2 id="ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น_ๆ"><span id=".E0.B8.82.E0.B9.89.E0.B8.AD.E0.B8.AB.E0.B9.89.E0.B8.B2.E0.B8.A1.E0.B9.83.E0.B8.8A.E0.B9.89.E0.B9.81.E0.B8.A5.E0.B8.B0.E0.B8.9B.E0.B8.8F.E0.B8.B4.E0.B8.AA.E0.B8.B1.E0.B8.A1.E0.B8.9E.E0.B8.B1.E0.B8.99.E0.B8.98.E0.B9.8C.E0.B8.81.E0.B8.B1.E0.B8.9A.E0.B8.A2.E0.B8.B2.E0.B8.AD.E0.B8.B7.E0.B9.88.E0.B8.99_.E0.B9.86"></span>ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น ๆ</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=21" title="แก้ไขส่วน: ข้อห้ามใช้และปฏิสัมพันธ์กับยาอื่น ๆ"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ยาต่อไปนี้อาจจะเร่งให้เกิด<a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99%E0%B9%80%E0%B8%9B%E0%B9%87%E0%B8%99%E0%B8%9E%E0%B8%B4%E0%B8%A9" class="mw-redirect" title="เซโรโทนินเป็นพิษ">เซโรโทนินเป็นพิษ</a>ในคนไข้ที่ทาน SSRIs<sup id="cite_ref-107" class="reference"><a href="#cite_note-107"><span class="cite-bracket">&#91;</span>107<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-108" class="reference"><a href="#cite_note-108"><span class="cite-bracket">&#91;</span>108<span class="cite-bracket">&#93;</span></a></sup> </p> <div> <table width="100%" border="0" cellspacing="0" cellpadding="0" style="background-color:transparent;table-layout:fixed;"> <tbody><tr valign="top"> <td><div style="margin-right:20px;"> <ul><li>Linezolid</li> <li>Monoamine oxidase inhibitors (MAOIs) รวมทั้ง moclobemide, phenelzine, tranylcypromine, selegiline และ methylene blue</li> <li>Lithium</li> <li>Sibutramine</li> <li>MDMA (ecstasy)</li> <li>Dextromethorphan</li> <li><a href="/wiki/%E0%B8%97%E0%B8%A3%E0%B8%B2%E0%B8%A1%E0%B8%B2%E0%B8%94%E0%B8%AD%E0%B8%A5" title="ทรามาดอล">ทรามาดอล</a></li></ul> </div> </td> <td><div style="margin-right: 20px;"> <ul><li><a href="/wiki/%E0%B9%80%E0%B8%9E%E0%B8%97%E0%B8%B4%E0%B8%94%E0%B8%B5%E0%B8%99" title="เพทิดีน">เพทิดีน/meperidine</a></li> <li>St. John's wort</li> <li>Yohimbe</li> <li>ยาแก้ซึมเศร้าแบบ Tricyclic (TCAs)</li> <li>Serotonin-norepinephrine reuptake inhibitors (SNRIs)</li> <li>Buspirone</li> <li>Triptan</li> <li>Mirtazapine</li></ul> </div> </td></tr></tbody></table></div> <p>ยาแก้ปวดในกลุ่ม<a href="/wiki/%E0%B8%A2%E0%B8%B2%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%AD%E0%B8%B1%E0%B8%81%E0%B9%80%E0%B8%AA%E0%B8%9A%E0%B8%8A%E0%B8%99%E0%B8%B4%E0%B8%94%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B9%83%E0%B8%8A%E0%B9%88%E0%B8%AA%E0%B9%80%E0%B8%95%E0%B8%AD%E0%B8%A3%E0%B8%AD%E0%B8%A2%E0%B8%94%E0%B9%8C" title="ยาแก้อักเสบชนิดไม่ใช่สเตอรอยด์">ยาแก้อักเสบชนิดไม่ใช่สเตอรอยด์</a> (NSAIDs) อาจขัดขวางและลดประสิทธิภาพของ SSRIs และอาจเพิ่มโอกาสเสี่ยงต่อ<a href="/wiki/%E0%B9%80%E0%B8%A5%E0%B8%B7%E0%B8%AD%E0%B8%94%E0%B8%AD%E0%B8%AD%E0%B8%81%E0%B9%83%E0%B8%99%E0%B8%81%E0%B8%A3%E0%B8%B0%E0%B9%80%E0%B8%9E%E0%B8%B2%E0%B8%B0%E0%B8%AD%E0%B8%B2%E0%B8%AB%E0%B8%B2%E0%B8%A3%E0%B9%81%E0%B8%A5%E0%B8%B0%E0%B8%A5%E0%B8%B3%E0%B9%84%E0%B8%AA%E0%B9%89" class="mw-redirect" title="เลือดออกในกระเพาะอาหารและลำไส้">เลือดออกในกระเพาะอาหารและลำไส้</a>เหตุ SSRI<sup id="cite_ref-Maudsley_57-1" class="reference"><a href="#cite_note-Maudsley-57"><span class="cite-bracket">&#91;</span>57<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-NSAIDs_59-1" class="reference"><a href="#cite_note-NSAIDs-59"><span class="cite-bracket">&#91;</span>59<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-109" class="reference"><a href="#cite_note-109"><span class="cite-bracket">&#91;</span>109<span class="cite-bracket">&#93;</span></a></sup> NSAIDs รวมทั้ง </p> <ul><li><a href="/wiki/%E0%B9%81%E0%B8%AD%E0%B8%AA%E0%B9%84%E0%B8%9E%E0%B8%A3%E0%B8%B4%E0%B8%99" title="แอสไพริน">แอสไพริน</a></li> <li><a href="/wiki/%E0%B9%84%E0%B8%AD%E0%B8%9A%E0%B8%B4%E0%B8%A7%E0%B8%9E%E0%B8%A3%E0%B8%AD%E0%B9%80%E0%B8%9F%E0%B8%99" title="ไอบิวพรอเฟน">ไอบิวพรอเฟน</a> (Advil, Nurofen)</li> <li><a href="/wiki/%E0%B8%99%E0%B8%B2%E0%B9%82%E0%B8%9B%E0%B8%A3%E0%B9%80%E0%B8%8B%E0%B8%99" class="mw-redirect" title="นาโปรเซน">นาโปรเซน</a> (Aleve)</li></ul> <p>มีปฏิสัมพันธ์ทาง<a href="/wiki/%E0%B9%80%E0%B8%A0%E0%B8%AA%E0%B8%B1%E0%B8%8A%E0%B8%88%E0%B8%A5%E0%B8%99%E0%B8%A8%E0%B8%B2%E0%B8%AA%E0%B8%95%E0%B8%A3%E0%B9%8C" title="เภสัชจลนศาสตร์">เภสัชจลนศาสตร์</a>ที่เป็นไปได้ระหว่าง SSRIs ชนิดต่าง ๆ กับยาอื่น ๆ โดยมากเพราะเหตุว่า SSRI สามารถยับยั้ง<a href="/wiki/%E0%B9%84%E0%B8%8B%E0%B9%82%E0%B8%97%E0%B9%82%E0%B8%84%E0%B8%A3%E0%B8%A1" title="ไซโทโครม">ไซโทโครม</a> P450 ใน<a href="/wiki/%E0%B8%95%E0%B8%B1%E0%B8%9A" title="ตับ">ตับ</a>ได้<sup id="cite_ref-GG_110-0" class="reference"><a href="#cite_note-GG-110"><span class="cite-bracket">&#91;</span>110<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-111" class="reference"><a href="#cite_note-111"><span class="cite-bracket">&#91;</span>111<span class="cite-bracket">&#93;</span></a></sup> </p> <table class="wikitable"> <tbody><tr> <th>ชื่อยา</th> <th>CYP1A2</th> <th>CYP2C9</th> <th>CYP2C19</th> <th>CYP2D6</th> <th>CYP3A4</th> <th>CYP2B6 </th></tr> <tr> <td>Citalopram</td> <td>+</td> <td>0</td> <td>0</td> <td>+</td> <td>0</td> <td>0 </td></tr> <tr> <td>Escitalopram</td> <td>0</td> <td>0</td> <td>0</td> <td>+</td> <td>0</td> <td>0 </td></tr> <tr> <td><a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a></td> <td>+</td> <td>++</td> <td>+/++</td> <td>+++</td> <td>+</td> <td>+ </td></tr> <tr> <td>Fluvoxamine</td> <td>+++</td> <td>++</td> <td>+++</td> <td>+</td> <td>+</td> <td>+ </td></tr> <tr> <td>Paroxetine</td> <td>+</td> <td>+</td> <td>+</td> <td>+++</td> <td>+</td> <td>+++ </td></tr> <tr> <td>Sertraline</td> <td>+</td> <td>+</td> <td>+/++</td> <td>+</td> <td>+</td> <td>+ </td></tr></tbody></table> <p><b>คำอธิบายสัญลักษณ์:</b><br /> 0 — ไม่มีฤทธิ์ยับยั้ง<br /> + — ฤทธิ์อ่อน<br /> ++ — ฤทธิ์กลาง<br /> +++ — ฤทธิ์แรง </p> <div class="mw-heading mw-heading2"><h2 id="รายการยา"><span id=".E0.B8.A3.E0.B8.B2.E0.B8.A2.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.A2.E0.B8.B2"></span>รายการยา</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=22" title="แก้ไขส่วน: รายการยา"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ยาในกลุ่มนี้รวมทั้ง </p> <div> <table width="100%" border="0" cellspacing="0" cellpadding="0" style="background-color:transparent;table-layout:fixed;"> <tbody><tr valign="top"> <td><div style="margin-right:20px;"> <p><b>สามัญสุด:</b> </p> <ul><li>citalopram</li> <li>escitalopram</li> <li><a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a></li> <li>fluvoxamine</li> <li>paroxetine</li> <li>sertraline</li></ul> </div> </td> <td><div style="margin-right: 20px;"> <p><b>อื่น ๆ:</b> </p> <ul><li>dapoxetine</li> <li>indalpine (หยุดขาย)</li> <li>zimelidine (หยุดขาย)</li> <li>cericlamine (ถึงการทดลองทางคลินิกระยะ 3 แล้วหยุดในปี 2542)</li></ul> </div> </td></tr></tbody></table></div> <table class="wikitable" style="font-size:smaller; text-align:center"> <tbody><tr> <th colspan="6">Selective serotonin reuptake inhibitors (SSRIs) </th></tr> <tr> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Citalopram.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5d/Citalopram.svg/175px-Citalopram.svg.png" decoding="async" width="175" height="125" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5d/Citalopram.svg/263px-Citalopram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5d/Citalopram.svg/350px-Citalopram.svg.png 2x" data-file-width="512" data-file-height="366" /></a></span> <p>Citalopram </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Dapoxetine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/26/Dapoxetine.svg/150px-Dapoxetine.svg.png" decoding="async" width="150" height="100" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/26/Dapoxetine.svg/225px-Dapoxetine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/26/Dapoxetine.svg/300px-Dapoxetine.svg.png 2x" data-file-width="512" data-file-height="341" /></a></span> <p>Dapoxetine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Escitalopram.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Escitalopram.svg/175px-Escitalopram.svg.png" decoding="async" width="175" height="125" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Escitalopram.svg/263px-Escitalopram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/04/Escitalopram.svg/350px-Escitalopram.svg.png 2x" data-file-width="512" data-file-height="366" /></a></span> <p>Escitalopram </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Fluoxetine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Fluoxetine.svg/175px-Fluoxetine.svg.png" decoding="async" width="175" height="91" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Fluoxetine.svg/263px-Fluoxetine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/83/Fluoxetine.svg/350px-Fluoxetine.svg.png 2x" data-file-width="512" data-file-height="265" /></a></span> <p><a href="/wiki/%E0%B8%9F%E0%B8%A5%E0%B8%B9%E0%B8%AD%E0%B9%8A%E0%B8%AD%E0%B8%81%E0%B8%8B%E0%B8%B4%E0%B8%95%E0%B8%B4%E0%B8%99" class="mw-redirect" title="ฟลูอ๊อกซิติน">ฟลูอ๊อกซิติน</a> </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Fluvoxamine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Fluvoxamine.svg/185px-Fluvoxamine.svg.png" decoding="async" width="185" height="143" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Fluvoxamine.svg/278px-Fluvoxamine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/Fluvoxamine.svg/370px-Fluvoxamine.svg.png 2x" data-file-width="512" data-file-height="395" /></a></span> <p>Fluvoxamine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Panuramine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/Panuramine.svg/250px-Panuramine.svg.png" decoding="async" width="250" height="75" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/Panuramine.svg/375px-Panuramine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/Panuramine.svg/500px-Panuramine.svg.png 2x" data-file-width="512" data-file-height="153" /></a></span> <p>Panuramine </p> </td></tr> <tr> <th colspan="5"> </th></tr> <tr> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Indalpine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3b/Indalpine.svg/165px-Indalpine.svg.png" decoding="async" width="165" height="86" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3b/Indalpine.svg/248px-Indalpine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3b/Indalpine.svg/330px-Indalpine.svg.png 2x" data-file-width="512" data-file-height="268" /></a></span> <p>Indalpine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Paroxetine-2D-skeletal.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8b/Paroxetine-2D-skeletal.svg/150px-Paroxetine-2D-skeletal.svg.png" decoding="async" width="150" height="139" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8b/Paroxetine-2D-skeletal.svg/225px-Paroxetine-2D-skeletal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8b/Paroxetine-2D-skeletal.svg/300px-Paroxetine-2D-skeletal.svg.png 2x" data-file-width="512" data-file-height="475" /></a></span> <p>Paroxetine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Femoxetine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Femoxetine.svg/165px-Femoxetine.svg.png" decoding="async" width="165" height="129" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Femoxetine.svg/248px-Femoxetine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Femoxetine.svg/330px-Femoxetine.svg.png 2x" data-file-width="512" data-file-height="401" /></a></span> <p>Femoxetine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Sertraline.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Sertraline.svg/155px-Sertraline.svg.png" decoding="async" width="155" height="122" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Sertraline.svg/233px-Sertraline.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Sertraline.svg/310px-Sertraline.svg.png 2x" data-file-width="512" data-file-height="403" /></a></span> <p>Sertraline </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Zimelidine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Zimelidine.svg/135px-Zimelidine.svg.png" decoding="async" width="135" height="113" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Zimelidine.svg/203px-Zimelidine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Zimelidine.svg/270px-Zimelidine.svg.png 2x" data-file-width="512" data-file-height="430" /></a></span> <p>Zimelidine </p> </td> <td><span typeof="mw:File"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Cericlamine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Cericlamine.svg/140px-Cericlamine.svg.png" decoding="async" width="140" height="81" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Cericlamine.svg/210px-Cericlamine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Cericlamine.svg/280px-Cericlamine.svg.png 2x" data-file-width="512" data-file-height="297" /></a></span> <p>Cericlamine </p> </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="ยาที่เกี่ยวข้องกัน"><span id=".E0.B8.A2.E0.B8.B2.E0.B8.97.E0.B8.B5.E0.B9.88.E0.B9.80.E0.B8.81.E0.B8.B5.E0.B9.88.E0.B8.A2.E0.B8.A7.E0.B8.82.E0.B9.89.E0.B8.AD.E0.B8.87.E0.B8.81.E0.B8.B1.E0.B8.99"></span>ยาที่เกี่ยวข้องกัน</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=23" title="แก้ไขส่วน: ยาที่เกี่ยวข้องกัน"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs เป็นกลุ่มย่อยของยา serotonin uptake inhibitors ซึ่งรวมสารยับยั้งแบบ non-selective (ที่ยึด<a href="/wiki/%E0%B8%A5%E0%B8%B4%E0%B9%81%E0%B8%81%E0%B8%99%E0%B8%94%E0%B9%8C" title="ลิแกนด์">ลิแกนด์</a>อย่างไม่เฉพาะเจาะจง) โดยมียาที่ออกฤทธิ์ต่อระบบเซโรโทนินอื่น ๆ รวมทั้ง serotonin-norepinephrine reuptake inhibitor และ serotonin-norepinephrine-dopamine reuptake inhibitor ซึ่งใช้อย่างสามัญเป็นยาแก้ซึมเศร้าเหมือนกัน </p> <div class="mw-heading mw-heading2"><h2 id="กลไกการออกฤทธิ์"><span id=".E0.B8.81.E0.B8.A5.E0.B9.84.E0.B8.81.E0.B8.81.E0.B8.B2.E0.B8.A3.E0.B8.AD.E0.B8.AD.E0.B8.81.E0.B8.A4.E0.B8.97.E0.B8.98.E0.B8.B4.E0.B9.8C"></span>กลไกการออกฤทธิ์</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=24" title="แก้ไขส่วน: กลไกการออกฤทธิ์"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/%E0%B9%84%E0%B8%9F%E0%B8%A5%E0%B9%8C:Reuptake_both.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8e/Reuptake_both.png/350px-Reuptake_both.png" decoding="async" width="350" height="233" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8e/Reuptake_both.png/525px-Reuptake_both.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8e/Reuptake_both.png/700px-Reuptake_both.png 2x" data-file-width="1200" data-file-height="800" /></a><figcaption>ภาพ<a href="/wiki/%E0%B9%84%E0%B8%8B%E0%B9%81%E0%B8%99%E0%B8%9B%E0%B8%AA%E0%B9%8C" class="mw-redirect" title="ไซแนปส์">ไซแนปส์</a>ในกระบวนการ re-uptake ให้สังเกตว่า สารสื่อประสาทบางส่วนจะสูญไปและไม่ได้นำกลับไปใช้ใหม่ <b>เซลล์ก่อนไซแนปส์</b> (บน) <b>เซลล์หลังไซแนปส์</b> (ล่าง) </figcaption></figure> <p>ใน<a href="/wiki/%E0%B8%AA%E0%B8%A1%E0%B8%AD%E0%B8%87" title="สมอง">สมอง</a> <a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B8%A5%E0%B8%A5%E0%B9%8C%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="เซลล์ประสาท">เซลล์ประสาท</a> (หรือนิวรอน) จะส่งข้อมูล/สัญญาณไปยังอีกเซลล์หนึ่งผ่านช่อง<a href="/wiki/%E0%B9%84%E0%B8%8B%E0%B9%81%E0%B8%99%E0%B8%9B%E0%B8%AA%E0%B9%8C" class="mw-redirect" title="ไซแนปส์">ไซแนปส์</a>โดยกระบวนการเคมี เซลล์ก่อนไซแนปส์ (presynaptic cell) ที่ส่งข้อมูลจะปล่อย<a href="/wiki/%E0%B8%AA%E0%B8%B2%E0%B8%A3%E0%B8%AA%E0%B8%B7%E0%B9%88%E0%B8%AD%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%B2%E0%B8%97" title="สารสื่อประสาท">สารสื่อประสาท</a> (neurotransmitter) รวมทั้ง<a href="/wiki/%E0%B9%80%E0%B8%8B%E0%B9%82%E0%B8%A3%E0%B9%82%E0%B8%97%E0%B8%99%E0%B8%B4%E0%B8%99" title="เซโรโทนิน">เซโรโทนิน</a> เข้าไปในช่องนั้น ตัวรับ (receptor) บนผิวเซลล์หลังไซแนปส์ (postsynaptic cell) ที่เป็นผู้รับข้อมูล ก็จะยอมรับสารสื่อประสาทนั้น และผ่านการกระตุ้นเช่นนั้น ก็จะส่งข้อมูล/สัญญาณต่อไป สารสื่อประสาทประมาณ 10% จะสูญไปในกระบวนการนี้ ตัวรับจะปล่อยสารสื่อประสาท 90% ที่เหลือ โดยมี<a href="/wiki/%E0%B9%82%E0%B8%9B%E0%B8%A3%E0%B8%95%E0%B8%B5%E0%B8%99" title="โปรตีน">โปรตีน</a>ที่เรียกว่า monoamine transporter (ตัวขนส่งโมโนอะมีน) เป็นผู้นำสารเข้าไปในเซลล์ก่อนไซแนปส์ เป็นกระบวนการที่เรียกว่า "reuptake" (การนำไปใช้ใหม่) </p><p>SSRIs ยับยั้งการนำเซโรโทนินไปใช้ใหม่ และดังนั้น เซโรโทนินจึงอยู่ในช่องไซแนปส์นานกว่าที่ปกติจะอยู่ และอาจจะกระตุ้นตัวรับของเซลล์หลังไซแนปส์อย่างซ้ำ ๆ ในระยะสั้น นี่ทำให้เกิดการส่งสัญญาณเพิ่มขึ้นข้ามไซแนปส์ที่เซโรโทนินทำหน้าที่เป็นสารสื่อประสาทหลัก แต่ถ้าได้ยานาน ๆ ตัวรับเซโรโทนินในเซลล์หลังไซแนปส์ที่ทำงานเพิ่มขึ้น จะทำให้เกิดการส่งสัญญาณให้เซลล์ก่อนไซแนปส์สังเคราะห์และปล่อยเซโรโทนินน้อยลง </p><p>ระดับเซโรโทนินภายในไซแนปส์ก็จะลดลง แล้วเพิ่มขึ้นอีก ซึ่งในที่สุดนำไปสู่การลดจำนวน (downregulation) ของตัวรับเซโรโทนินหลังไซแนปส์<sup id="cite_ref-112" class="reference"><a href="#cite_note-112"><span class="cite-bracket">&#91;</span>112<span class="cite-bracket">&#93;</span></a></sup> ผลโดยอ้อมอื่น ๆ อาจรวมทั้งการเพิ่มนอร์เอพิเนฟริน เพิ่มระดับ cyclic AMP ใน<a href="/wiki/%E0%B8%99%E0%B8%B4%E0%B8%A7%E0%B8%A3%E0%B8%AD%E0%B8%99" class="mw-redirect" title="นิวรอน">นิวรอน</a> และ เพิ่มระดับปัจจัยควบคุม (regulatory factor) เช่น BDNF (Brain-derived neurotrophic factor) และ CREB<sup id="cite_ref-Kolb_2006_113-0" class="reference"><a href="#cite_note-Kolb_2006-113"><span class="cite-bracket">&#91;</span>113<span class="cite-bracket">&#93;</span></a></sup> แต่เพราะไม่มี<a href="/wiki/%E0%B8%97%E0%B8%A4%E0%B8%A9%E0%B8%8E%E0%B8%B5" title="ทฤษฎี">ทฤษฎี</a>ทางชีววิทยาที่สมบูรณ์ของความผิดปกติทางอารมณ์ จึงไม่มี<a href="/wiki/%E0%B8%AA%E0%B8%A1%E0%B8%A1%E0%B8%95%E0%B8%B4%E0%B8%90%E0%B8%B2%E0%B8%99" title="สมมติฐาน">สมมติฐาน</a>ที่ยอมรับกันอย่างกว้างขวางว่า ความเปลี่ยนแปลงเช่นนี้นำไปสู่ผลของ SSRIs ที่ทำให้อารมณ์ดีขึ้นและลดความวิตกกังวลได้อย่างไร </p> <div class="mw-heading mw-heading3"><h3 id="เภสัชพันธุศาสตร์"><span id=".E0.B9.80.E0.B8.A0.E0.B8.AA.E0.B8.B1.E0.B8.8A.E0.B8.9E.E0.B8.B1.E0.B8.99.E0.B8.98.E0.B8.B8.E0.B8.A8.E0.B8.B2.E0.B8.AA.E0.B8.95.E0.B8.A3.E0.B9.8C"></span>เภสัชพันธุศาสตร์</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=25" title="แก้ไขส่วน: เภสัชพันธุศาสตร์"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r9751016"><div role="note" class="hatnote navigation-not-searchable">ข้อมูลเพิ่มเติม: <a href="/wiki/%E0%B9%80%E0%B8%A0%E0%B8%AA%E0%B8%B1%E0%B8%8A%E0%B8%9E%E0%B8%B1%E0%B8%99%E0%B8%98%E0%B8%B8%E0%B8%A8%E0%B8%B2%E0%B8%AA%E0%B8%95%E0%B8%A3%E0%B9%8C" title="เภสัชพันธุศาสตร์">เภสัชพันธุศาสตร์</a></div> <p>งานวิจัยจำนวนมากมุ่งหาตัวบ่งชี้ทางพันธุกรรม (genetic marker) เพื่อพยากรณ์ว่า คนไข้จะตอบสนองต่อ SSRIs หรือมีผลข้างเคียงที่จะเป็นเหตุให้เลิกยาหรือไม่ แม้ว่าการทดสอบเหล่านี้ยังไม่พร้อมใช้ในการรักษาทั่วไป<sup id="cite_ref-114" class="reference"><a href="#cite_note-114"><span class="cite-bracket">&#91;</span>114<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Single-nucleotide_polymorphism" class="mw-redirect" title="Single-nucleotide polymorphism">Single-nucleotide polymorphism</a> ของ<a href="/wiki/%E0%B8%A2%E0%B8%B5%E0%B8%99" title="ยีน">ยีน</a> 5-HT(2A) มี<a href="/wiki/%E0%B8%AA%E0%B8%AB%E0%B8%AA%E0%B8%B1%E0%B8%A1%E0%B8%9E%E0%B8%B1%E0%B8%99%E0%B8%98%E0%B9%8C" title="สหสัมพันธ์">สหสัมพันธ์</a>กับการเลิกยา paroxetine ของคนไข้สูงอายุเนื่องจากผลข้างเคียง แต่ไม่มีกับการเลิกยา mirtazapine ซึ่งเป็นยาประเภท non-SSRI<sup id="cite_ref-115" class="reference"><a href="#cite_note-115"><span class="cite-bracket">&#91;</span>115<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="SSRIs_เทียบกับ_TCAs"><span id="SSRIs_.E0.B9.80.E0.B8.97.E0.B8.B5.E0.B8.A2.E0.B8.9A.E0.B8.81.E0.B8.B1.E0.B8.9A_TCAs"></span>SSRIs เทียบกับ TCAs</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=26" title="แก้ไขส่วน: SSRIs เทียบกับ TCAs"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SSRIs เรียกว่า selective (โดยเฉพาะ) ก็เพราะมีผลต่อกระบวนการนำเซโรโทนินไปใช้ใหม่เท่านั้น ไม่เหมือนกับยาแก้ซึมเศร้าก่อนนั้น ซึ่งมีผลต่อสารสื่อประสาทแบบโมโนอะมีนอื่น ๆ ด้วย และดังนั้น SSRIs จึงมีผลข้างเคียงน้อยกว่า </p><p>ดูเหมือนว่าจะไม่มีผลต่างที่สำคัญระหว่างประสิทธิผลของ SSRIs และยาแก้ซึมเศร้าแบบ tricyclic ซึ่งเคยเป็นกลุ่มยาที่ใช้สามัญมากที่สุดก่อน SSRIs<sup id="cite_ref-116" class="reference"><a href="#cite_note-116"><span class="cite-bracket">&#91;</span>116<span class="cite-bracket">&#93;</span></a></sup> แต่ว่า SSRIs มีข้อได้เปรียบที่สำคัญเพราะว่า ขนาดที่ก่อพิษสูง และดังนั้น ยากกว่าที่จะใช้<a href="/wiki/%E0%B8%86%E0%B9%88%E0%B8%B2%E0%B8%95%E0%B8%B1%E0%B8%A7%E0%B8%95%E0%B8%B2%E0%B8%A2" class="mw-redirect" title="ฆ่าตัวตาย">ฆ่าตัวตาย</a> นอกจากนั้นแล้ว ยังมี<a href="/wiki/%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%84%E0%B8%A1%E0%B9%88%E0%B8%9E%E0%B8%B6%E0%B8%87%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%AA%E0%B8%87%E0%B8%84%E0%B9%8C%E0%B8%88%E0%B8%B2%E0%B8%81%E0%B8%A2%E0%B8%B2" title="อาการไม่พึงประสงค์จากยา">ผลข้างเคียง</a>ที่น้อยกว่าและเบากว่า ยาแก้ซึมเศร้าแบบ Tricyclic ยังมีความเสี่ยงสูงกว่าต่อผลข้างเคียงที่รุนแรงทางหลอดเลือดหัวใจ ซึ่ง SSRIs ไม่มี </p><p>SSRIs มีฤทธิ์ต่อวิถีส่งสัญญาณ (signal pathway) เช่น cAMP (Cyclic AMP) ของเซลล์ประสาทหลังไซแนปส์ ซึ่งนำไปสู่การปล่อย Brain-Derived Neurotrophic Factor (BDNF) ซึ่งมีหน้าที่ปรับปรุงการเติบโตและการอยู่รอดทั้งของเซลล์ประสาทใน<a href="/wiki/%E0%B8%84%E0%B8%AD%E0%B8%A3%E0%B9%8C%E0%B9%80%E0%B8%97%E0%B8%81%E0%B8%8B%E0%B9%8C" title="คอร์เทกซ์">คอร์เทกซ์</a>และของ<a href="/wiki/%E0%B9%84%E0%B8%8B%E0%B9%81%E0%B8%99%E0%B8%9B%E0%B8%AA%E0%B9%8C" class="mw-redirect" title="ไซแนปส์">ไซแนปส์</a><sup id="cite_ref-Kolb_2006_113-1" class="reference"><a href="#cite_note-Kolb_2006-113"><span class="cite-bracket">&#91;</span>113<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="สังคมและวัฒนธรรม"><span id=".E0.B8.AA.E0.B8.B1.E0.B8.87.E0.B8.84.E0.B8.A1.E0.B9.81.E0.B8.A5.E0.B8.B0.E0.B8.A7.E0.B8.B1.E0.B8.92.E0.B8.99.E0.B8.98.E0.B8.A3.E0.B8.A3.E0.B8.A1"></span>สังคมและวัฒนธรรม</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=27" title="แก้ไขส่วน: สังคมและวัฒนธรรม"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="ข้อขัดแย้ง"><span id=".E0.B8.82.E0.B9.89.E0.B8.AD.E0.B8.82.E0.B8.B1.E0.B8.94.E0.B9.81.E0.B8.A2.E0.B9.89.E0.B8.87"></span>ข้อขัดแย้ง</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=28" title="แก้ไขส่วน: ข้อขัดแย้ง"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>งานศึกษาที่ตรวจสอบการตีพิมพ์ผลของยาแก้ซึมเศร้าที่ FDA ตรวจสอบ สรุปว่า งานที่แสดงผลดีของยาต่อโรคมีโอกาสที่จะตีพิมพ์สูงกว่างานที่แสดงผลลบ (หรือผลว่าง)<sup id="cite_ref-pmid18199864_117-0" class="reference"><a href="#cite_note-pmid18199864-117"><span class="cite-bracket">&#91;</span>117<span class="cite-bracket">&#93;</span></a></sup> </p><p>ส่วนจิตแพทย์ผู้หนึ่งอ้างว่า มีสัญญาณเตือนมาหลายปีแล้วก่อนที่เจ้าหน้าที่ควบคุมจะเริ่มติดป้ายเตือนว่า ยาแก้ซึมเศร้าอาจเป็นเหตุของความคิดฆ่าตัวตาย<sup id="cite_ref-dhintrev_118-0" class="reference"><a href="#cite_note-dhintrev-118"><span class="cite-bracket">&#91;</span>118<span class="cite-bracket">&#93;</span></a></sup> แต่ว่า ตอนที่ FDA บังคับให้ติดป้าย ก็ยังมีนักวิชาการอื่น ๆ ที่อ้างว่า หลักฐานในเรื่องอันตรายนี้ไม่น่าเชื่อถือ<sup id="cite_ref-119" class="reference"><a href="#cite_note-119"><span class="cite-bracket">&#91;</span>119<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-120" class="reference"><a href="#cite_note-120"><span class="cite-bracket">&#91;</span>120<span class="cite-bracket">&#93;</span></a></sup> และคนอื่น ๆ ก็ยังกล่าวเช่นนั้นต่อไปหลังจากการบังคับใช้ป้ายเตือน<sup id="cite_ref-121" class="reference"><a href="#cite_note-121"><span class="cite-bracket">&#91;</span>121<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-122" class="reference"><a href="#cite_note-122"><span class="cite-bracket">&#91;</span>122<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="เชิงอรรถและอ้างอิง"><span id=".E0.B9.80.E0.B8.8A.E0.B8.B4.E0.B8.87.E0.B8.AD.E0.B8.A3.E0.B8.A3.E0.B8.96.E0.B9.81.E0.B8.A5.E0.B8.B0.E0.B8.AD.E0.B9.89.E0.B8.B2.E0.B8.87.E0.B8.AD.E0.B8.B4.E0.B8.87"></span>เชิงอรรถและอ้างอิง</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=29" title="แก้ไขส่วน: เชิงอรรถและอ้างอิง"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist columns references-column-width" style="-moz-column-width: 30em; -webkit-column-width: 30em; column-width: 30em; list-style-type: decimal;"> <ol class="references"> <li id="cite_note-BARLOW-1"><span class="mw-cite-backlink"><a href="#cite_ref-BARLOW_1-0">↑</a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r10205087">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite id="CITEREFBarlow,_David_H;_Durand,_V._Mark2009" class="citation book cs1">Barlow, David H; Durand, V. Mark (2009). "Chapter 7: Mood Disorders and Suicide". <i>Abnormal Psychology: An Integrative Approach</i> (Fifth&#160;ed.). Belmont, CA: Wadsworth Cengage Learning. p.&#160;239. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/0-495-09556-7" title="พิเศษ:แหล่งหนังสือ/0-495-09556-7"><bdi>0-495-09556-7</bdi></a>. <a href="/wiki/OCLC_(identifier)" class="mw-redirect" title="OCLC (identifier)">OCLC</a>&#160;<a rel="nofollow" class="external text" href="//www.worldcat.org/oclc/192055408">192055408</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=bookitem&amp;rft.atitle=Chapter+7%3A+Mood+Disorders+and+Suicide&amp;rft.btitle=Abnormal+Psychology%3A+An+Integrative+Approach&amp;rft.place=Belmont%2C+CA&amp;rft.pages=239&amp;rft.edition=Fifth&amp;rft.pub=Wadsworth+Cengage+Learning&amp;rft.date=2009&amp;rft_id=info%3Aoclcnum%2F192055408&amp;rft.isbn=0-495-09556-7&amp;rft.au=Barlow%2C+David+H%3B+Durand%2C+V.+Mark&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_book" title="แม่แบบ:Cite book">cite book</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_multiple_names:_authors_list" title="หมวดหมู่:CS1 maint: multiple names: authors list">ลิงก์</a>)</span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://pi.lilly.com/us/prozac.pdf">"Prozac"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. Lilly and Company. p.&#160;20.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Prozac&amp;rft.pages=20&amp;rft.pub=Lilly+and+Company&amp;rft_id=http%3A%2F%2Fpi.lilly.com%2Fus%2Fprozac.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-PRESCORN2004-3"><span class="mw-cite-backlink"><a href="#cite_ref-PRESCORN2004_3-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFSheldon_H._PreskornHohn_P._FeighnerChristina_Y._StangaRuth_Ross2004" class="citation book cs1">Preskorn, SH; Ross, R; Stanga, CY (2004). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=sO_hArhCxwMC&amp;pg=PA241">"Selective Serotonin Reuptake Inhibitors"</a>. ใน Sheldon H. Preskorn; Hohn P. Feighner; Christina Y. Stanga; Ruth Ross (บ.ก.). <i>Antidepressants: Past, Present and Future</i>. Berlin: Springer. pp.&#160;241–62. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/978-3-540-43054-4" title="พิเศษ:แหล่งหนังสือ/978-3-540-43054-4"><bdi>978-3-540-43054-4</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=bookitem&amp;rft.atitle=Selective+Serotonin+Reuptake+Inhibitors&amp;rft.btitle=Antidepressants%3A+Past%2C+Present+and+Future&amp;rft.place=Berlin&amp;rft.pages=241-62&amp;rft.pub=Springer&amp;rft.date=2004&amp;rft.isbn=978-3-540-43054-4&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DsO_hArhCxwMC%26pg%3DPA241&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_book" title="แม่แบบ:Cite book">cite book</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-JAMA2010-4"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-JAMA2010_4-0">4.0</a></sup> <sup><a href="#cite_ref-JAMA2010_4-1">4.1</a></sup></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fournier, JC; DeRubeis, RJ; Hollon, SD; Dimidjian, S; Amsterdam, JD; Shelton, RC; Fawcett, J (January 2010). <a rel="nofollow" class="external text" href="http://jama.ama-assn.org/cgi/content/short/303/1/47?home">"Antidepressant Drug Effects and Depression Severity"</a>. <i>JAMA: The Journal of the American Medical Association</i>. <b>303</b> (1): 47–53. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.2009.1943">10.1001/jama.2009.1943</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3712503">3712503</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20051569">20051569</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=JAMA%3A+The+Journal+of+the+American+Medical+Association&amp;rft.atitle=Antidepressant+Drug+Effects+and+Depression+Severity&amp;rft.volume=303&amp;rft.issue=1&amp;rft.pages=47-53&amp;rft.date=2010-01&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3712503%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F20051569&amp;rft_id=info%3Adoi%2F10.1001%2Fjama.2009.1943&amp;rft_id=http%3A%2F%2Fjama.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F303%2F1%2F47%3Fhome&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Kramer-5"><span class="mw-cite-backlink"><a href="#cite_ref-Kramer_5-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFKramer2011" class="citation news cs1">Kramer, Peter (7 September 2011). <a rel="nofollow" class="external text" href="http://www.nytimes.com/2011/07/10/opinion/sunday/10antidepressants.html">"In Defense of Antidepressants"</a>. <i>The New York Times</i><span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">13 July</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+New+York+Times&amp;rft.atitle=In+Defense+of+Antidepressants&amp;rft.date=2011-09-07&amp;rft.aulast=Kramer&amp;rft.aufirst=Peter&amp;rft_id=http%3A%2F%2Fwww.nytimes.com%2F2011%2F07%2F10%2Fopinion%2Fsunday%2F10antidepressants.html&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-Pies-6"><span class="mw-cite-backlink"><a href="#cite_ref-Pies_6-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFPies,_R2010" class="citation journal cs1">Pies, R (April 2010). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-clinical-psychopharmacology_2010-04_30_2/page/101">"Antidepressants Work, Sort of-Our System of Care Does Not"</a>. <i>Journal of Clinical Psychopharmacology</i>. <b>30</b> (2): 101–104. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FJCP.0b013e3181d52dea">10.1097/JCP.0b013e3181d52dea</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20520282">20520282</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Clinical+Psychopharmacology&amp;rft.atitle=Antidepressants+Work%2C+Sort+of-Our+System+of+Care+Does+Not&amp;rft.volume=30&amp;rft.issue=2&amp;rft.pages=101-104&amp;rft.date=2010-04&amp;rft_id=info%3Adoi%2F10.1097%2FJCP.0b013e3181d52dea&amp;rft_id=info%3Apmid%2F20520282&amp;rft.au=Pies%2C+R&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-clinical-psychopharmacology_2010-04_30_2%2Fpage%2F101&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFMedford" class="citation web cs1">Medford, Nick. <a rel="nofollow" class="external text" href="http://apt.rcpsych.org/content/11/2/92.full">"Understanding and treating depersonalization disorder"</a>. Advances in Psychiatric Treatment (2005)<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">11 November</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Understanding+and+treating+depersonalization+disorder&amp;rft.pub=Advances+in+Psychiatric+Treatment+%282005%29&amp;rft.aulast=Medford&amp;rft.aufirst=Nick&amp;rft_id=http%3A%2F%2Fapt.rcpsych.org%2Fcontent%2F11%2F2%2F92.full&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-NICE2009-8"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-NICE2009_8-0">8.0</a></sup> <sup><a href="#cite_ref-NICE2009_8-1">8.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20130928172709/http://www.nice.org.uk/nicemedia/pdf/CG%2090%20QRG%20LR%20FINAL.pdf">"www.nice.org.uk"</a> <span class="cs1-format">(PDF)</span>. <i>NICE</i>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.nice.org.uk/nicemedia/pdf/CG%2090%20QRG%20LR%20FINAL.pdf">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 28 September 2013<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=NICE&amp;rft.atitle=www.nice.org.uk&amp;rft_id=http%3A%2F%2Fwww.nice.org.uk%2Fnicemedia%2Fpdf%2FCG%252090%2520QRG%2520LR%2520FINAL.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-KIRSCH2008-9"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-KIRSCH2008_9-0">9.0</a></sup> <sup><a href="#cite_ref-KIRSCH2008_9-1">9.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Kirsch, I; Deacon, BJ; Huedo-Medina, TB; Scoboria, A; Moore, TJ; Johnson, BT (February 2008). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2253608">"Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration"</a>. <i>PLoS Medicine</i>. <b>5</b> (2): e45. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pmed.0050045">10.1371/journal.pmed.0050045</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2253608">2253608</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18303940">18303940</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=PLoS+Medicine&amp;rft.atitle=Initial+Severity+and+Antidepressant+Benefits%3A+A+Meta-Analysis+of+Data+Submitted+to+the+Food+and+Drug+Administration&amp;rft.volume=5&amp;rft.issue=2&amp;rft.pages=e45&amp;rft.date=2008-02&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2253608%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F18303940&amp;rft_id=info%3Adoi%2F10.1371%2Fjournal.pmed.0050045&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2253608&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-HORDER2010-10"><span class="mw-cite-backlink"><a href="#cite_ref-HORDER2010_10-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Horder, J; Matthews, P; Waldmann, R (June 2010). "Placebo, Prozac and PLoS: significant lessons for psychopharmacology". <i>Journal of Psychopharmacology (Oxford, England)</i>. <b>25</b> (10): 1277–88. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F0269881110372544">10.1177/0269881110372544</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20571143">20571143</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Psychopharmacology+%28Oxford%2C+England%29&amp;rft.atitle=Placebo%2C+Prozac+and+PLoS%3A+significant+lessons+for+psychopharmacology&amp;rft.volume=25&amp;rft.issue=10&amp;rft.pages=1277-88&amp;rft.date=2010-06&amp;rft_id=info%3Adoi%2F10.1177%2F0269881110372544&amp;rft_id=info%3Apmid%2F20571143&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-FOUNTOULAKIS2010-11"><span class="mw-cite-backlink"><a href="#cite_ref-FOUNTOULAKIS2010_11-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fountoulakis, KN; Möller, HJ (August 2010). "Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data". <i>The International Journal of Neuropsychopharmacology</i>. <b>14</b> (3): 1–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1017%2FS1461145710000957">10.1017/S1461145710000957</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20800012">20800012</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+International+Journal+of+Neuropsychopharmacology&amp;rft.atitle=Efficacy+of+antidepressants%3A+a+re-analysis+and+re-interpretation+of+the+Kirsch+data&amp;rft.volume=14&amp;rft.issue=3&amp;rft.pages=1-8&amp;rft.date=2010-08&amp;rft_id=info%3Adoi%2F10.1017%2FS1461145710000957&amp;rft_id=info%3Apmid%2F20800012&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><a href="#cite_ref-12">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="http://www.nice.org.uk/nicemedia/live/12329/45896/45896.pdf"><i>Depression: The NICE Guideline on the Treatment and Management of Depression in Adults (Updated Edition)</i></a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. RCPsych Publications. 2010. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/1-904671-85-3" title="พิเศษ:แหล่งหนังสือ/1-904671-85-3"><bdi>1-904671-85-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Depression%3A+The+NICE+Guideline+on+the+Treatment+and+Management+of+Depression+in+Adults+%28Updated+Edition%29&amp;rft.pub=RCPsych+Publications&amp;rft.date=2010&amp;rft.isbn=1-904671-85-3&amp;rft_id=http%3A%2F%2Fwww.nice.org.uk%2Fnicemedia%2Flive%2F12329%2F45896%2F45896.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><a href="#cite_ref-13">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gibbons, RD; Hur, K; Brown, CH; Davis, JM; Mann, JJ (June 2012). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3371295">"Benefits from antidepressants: synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxine"</a>. <i>Archives of General Psychiatry</i>. <b>69</b> (6): 572–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchgenpsychiatry.2011.2044">10.1001/archgenpsychiatry.2011.2044</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3371295">3371295</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22393205">22393205</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Archives+of+General+Psychiatry&amp;rft.atitle=Benefits+from+antidepressants%3A+synthesis+of+6-week+patient-level+outcomes+from+double-blind+placebo-controlled+randomized+trials+of+fluoxetine+and+venlafaxine&amp;rft.volume=69&amp;rft.issue=6&amp;rft.pages=572-9&amp;rft.date=2012-06&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3371295%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F22393205&amp;rft_id=info%3Adoi%2F10.1001%2Farchgenpsychiatry.2011.2044&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3371295&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><a href="#cite_ref-14">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fournier, JC; DeRubeis, RJ; Hollon, SD; Dimidjian, S; Amsterdam, JD; Shelton, RC; Fawcett, J (January 2010). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3712503">"Antidepressant drug effects and depression severity: a patient-level meta-analysis"</a>. <i>JAMA</i>. <b>303</b> (1): 47–53. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.2009.1943">10.1001/jama.2009.1943</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3712503">3712503</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20051569">20051569</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=JAMA&amp;rft.atitle=Antidepressant+drug+effects+and+depression+severity%3A+a+patient-level+meta-analysis&amp;rft.volume=303&amp;rft.issue=1&amp;rft.pages=47-53&amp;rft.date=2010-01&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3712503%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F20051569&amp;rft_id=info%3Adoi%2F10.1001%2Fjama.2009.1943&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3712503&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><a href="#cite_ref-15">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gartlehner, G; Hansen, RA; Morgan, LC; Thaler, K; Lux, L; Van Noord, M; Mager, U; Thieda, P; Gaynes, BN; Wilkins, T; Strobelberger, M; Lloyd, S; Reichenpfader, U; Lohr, KN (December 2011). "Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis". <i>Annals of Internal Medicine</i>. <b>155</b> (11): 772–85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7326%2F0003-4819-155-11-201112060-00009">10.7326/0003-4819-155-11-201112060-00009</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22147715">22147715</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Annals+of+Internal+Medicine&amp;rft.atitle=Comparative+benefits+and+harms+of+second-generation+antidepressants+for+treating+major+depressive+disorder%3A+an+updated+meta-analysis&amp;rft.volume=155&amp;rft.issue=11&amp;rft.pages=772-85&amp;rft.date=2011-12&amp;rft_id=info%3Adoi%2F10.7326%2F0003-4819-155-11-201112060-00009&amp;rft_id=info%3Apmid%2F22147715&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Hewt2012-16"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Hewt2012_16-0">16.0</a></sup> <sup><a href="#cite_ref-Hewt2012_16-1">16.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Hetrick, SE; McKenzie, JE; Cox, GR; Simmons, MB; Merry, SN (14 November 2012). "Newer generation antidepressants for depressive disorders in children and adolescents". <i>The Cochrane Database of Systematic Reviews</i>. <b>11</b>: CD004851. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.cd004851.pub3">10.1002/14651858.cd004851.pub3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23152227">23152227</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&amp;rft.atitle=Newer+generation+antidepressants+for+depressive+disorders+in+children+and+adolescents.&amp;rft.volume=11&amp;rft.pages=CD004851&amp;rft.date=2012-11-14&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.cd004851.pub3&amp;rft_id=info%3Apmid%2F23152227&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-urlwww.nice.org.ukb-17"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-urlwww.nice.org.ukb_17-0">17.0</a></sup> <sup><a href="#cite_ref-urlwww.nice.org.ukb_17-1">17.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20121021044157/http://www.nice.org.uk/nicemedia/live/13314/52599/52599.pdf">"Generalised anxiety disorder and panic disorder (with or without agoraphobia) in adults"</a> <span class="cs1-format">(PDF)</span>. <i>NICE</i>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.nice.org.uk/nicemedia/live/13314/52599/52599.pdf">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 21 October 2012<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">20 February</span> 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=NICE&amp;rft.atitle=Generalised+anxiety+disorder+and+panic+disorder+%28with+or+without+agoraphobia%29+in+adults&amp;rft_id=http%3A%2F%2Fwww.nice.org.uk%2Fnicemedia%2Flive%2F13314%2F52599%2F52599.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-Kapczinski-18"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Kapczinski_18-0">18.0</a></sup> <sup><a href="#cite_ref-Kapczinski_18-1">18.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFKapczinski,_F;_Lima,_MS;_Souza,_JS;_Schmitt,_R2003" class="citation journal cs1">Kapczinski, F; Lima, MS; Souza, JS; Schmitt, R (2003). Kapczinski, Flavio FK (บ.ก.). "Antidepressants for generalized anxiety disorder". <i>The Cochrane Database of Systematic Reviews</i> (2): CD003592. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD003592">10.1002/14651858.CD003592</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/12804478">12804478</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&amp;rft.atitle=Antidepressants+for+generalized+anxiety+disorder&amp;rft.issue=2&amp;rft.pages=CD003592&amp;rft.date=2003&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD003592&amp;rft_id=info%3Apmid%2F12804478&amp;rft.au=Kapczinski%2C+F%3B+Lima%2C+MS%3B+Souza%2C+JS%3B+Schmitt%2C+R&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_multiple_names:_authors_list" title="หมวดหมู่:CS1 maint: multiple names: authors list">ลิงก์</a>)</span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><a href="#cite_ref-19">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20081206033654/https://www.nice.org.uk/nicemedia/pdf/cg031niceguideline.pdf">"Obsessive-compulsive disorder: Core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder"</a> <span class="cs1-format">(PDF)</span>. November 2005. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.nice.org.uk/nicemedia/pdf/cg031niceguideline.pdf">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 6 December 2008<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Obsessive-compulsive+disorder%3A+Core+interventions+in+the+treatment+of+obsessive-compulsive+disorder+and+body+dysmorphic+disorder&amp;rft.date=2005-11&amp;rft_id=http%3A%2F%2Fwww.nice.org.uk%2Fnicemedia%2Fpdf%2Fcg031niceguideline.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><a href="#cite_ref-20">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFArroll,_B;_Elley,_CR;_Fishman,_T;_Goodyear-Smith,_FA;_Kenealy,_T;_Blashki,_G;_Kerse,_N;_Macgillivray,_S2009" class="citation journal cs1">Arroll, B; Elley, CR; Fishman, T; Goodyear-Smith, FA; Kenealy, T; Blashki, G; Kerse, N; Macgillivray, S (2009). Arroll, Bruce (บ.ก.). "Antidepressants versus placebo for depression in primary care". <i>The Cochrane Database of Systematic Reviews</i> (3): CD007954. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD007954">10.1002/14651858.CD007954</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/19588448">19588448</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&amp;rft.atitle=Antidepressants+versus+placebo+for+depression+in+primary+care&amp;rft.issue=3&amp;rft.pages=CD007954&amp;rft.date=2009&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD007954&amp;rft_id=info%3Apmid%2F19588448&amp;rft.au=Arroll%2C+B%3B+Elley%2C+CR%3B+Fishman%2C+T%3B+Goodyear-Smith%2C+FA%3B+Kenealy%2C+T%3B+Blashki%2C+G%3B+Kerse%2C+N%3B+Macgillivray%2C+S&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_multiple_names:_authors_list" title="หมวดหมู่:CS1 maint: multiple names: authors list">ลิงก์</a>)</span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><a href="#cite_ref-21">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.medscape.com/viewarticle/570825+">"Medscape Log In"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130413110435/http://www.medscape.com/viewarticle/570825">เก็บ</a>จากแหล่งเดิมเมื่อ 13 April 2013<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Medscape+Log+In&amp;rft_id=http%3A%2F%2Fwww.medscape.com%2Fviewarticle%2F570825%2B&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><a href="#cite_ref-22">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFรองศาสตราจารย์_ดร.ประตาป_สิงหศิวานนท์,_ผู้ช่วยศาสตราจารย์_ดร.จรณิต_แก้วกังวาล2554" class="citation web cs1">รองศาสตราจารย์ ดร.ประตาป สิงหศิวานนท์, ผู้ช่วยศาสตราจารย์ ดร.จรณิต แก้วกังวาล (2554). ศาสตราจารย์แพทย์หญิงพรรณี ปิติสุทธิธรรม, รองศาสตราจารย์ ดร.ชยันต์ พิเชียรสุนทร (บ.ก.). <a rel="nofollow" class="external text" href="http://www.tm.mahidol.ac.th/th/tropical-medicine-knowledge/book-clinic/Textbook-of-Clinical-Researh/013-084.pdf">"บทที่ 2 รูปแบบการวิจัยทางคลินิก"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. <i>ตำราการวิจัยทางคลินิก (Textbook of Clinical Research)</i>. มหาวิทยาลัยมหิดล. p.&#160;49-51. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/978-974-11-1462-7" title="พิเศษ:แหล่งหนังสือ/978-974-11-1462-7"><bdi>978-974-11-1462-7</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150707075223/http://www.tm.mahidol.ac.th/th/tropical-medicine-knowledge/book-clinic/Textbook-of-Clinical-Researh/013-084.pdf">เก็บ</a> <span class="cs1-format">(PDF)</span>จากแหล่งเดิมเมื่อ 7 July 2015<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">22 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=%E0%B8%95%E0%B8%B3%E0%B8%A3%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A7%E0%B8%B4%E0%B8%88%E0%B8%B1%E0%B8%A2%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%84%E0%B8%A5%E0%B8%B4%E0%B8%99%E0%B8%B4%E0%B8%81+%28Textbook+of+Clinical+Research%29&amp;rft.atitle=%E0%B8%9A%E0%B8%97%E0%B8%97%E0%B8%B5%E0%B9%88+2+%E0%B8%A3%E0%B8%B9%E0%B8%9B%E0%B9%81%E0%B8%9A%E0%B8%9A%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A7%E0%B8%B4%E0%B8%88%E0%B8%B1%E0%B8%A2%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%84%E0%B8%A5%E0%B8%B4%E0%B8%99%E0%B8%B4%E0%B8%81&amp;rft.pages=49-51&amp;rft.date=2554&amp;rft.isbn=978-974-11-1462-7&amp;rft.au=%E0%B8%A3%E0%B8%AD%E0%B8%87%E0%B8%A8%E0%B8%B2%E0%B8%AA%E0%B8%95%E0%B8%A3%E0%B8%B2%E0%B8%88%E0%B8%B2%E0%B8%A3%E0%B8%A2%E0%B9%8C+%E0%B8%94%E0%B8%A3.%E0%B8%9B%E0%B8%A3%E0%B8%B0%E0%B8%95%E0%B8%B2%E0%B8%9B+%E0%B8%AA%E0%B8%B4%E0%B8%87%E0%B8%AB%E0%B8%A8%E0%B8%B4%E0%B8%A7%E0%B8%B2%E0%B8%99%E0%B8%99%E0%B8%97%E0%B9%8C%2C+%E0%B8%9C%E0%B8%B9%E0%B9%89%E0%B8%8A%E0%B9%88%E0%B8%A7%E0%B8%A2%E0%B8%A8%E0%B8%B2%E0%B8%AA%E0%B8%95%E0%B8%A3%E0%B8%B2%E0%B8%88%E0%B8%B2%E0%B8%A3%E0%B8%A2%E0%B9%8C+%E0%B8%94%E0%B8%A3.%E0%B8%88%E0%B8%A3%E0%B8%93%E0%B8%B4%E0%B8%95+%E0%B9%81%E0%B8%81%E0%B9%89%E0%B8%A7%E0%B8%81%E0%B8%B1%E0%B8%87%E0%B8%A7%E0%B8%B2%E0%B8%A5&amp;rft_id=http%3A%2F%2Fwww.tm.mahidol.ac.th%2Fth%2Ftropical-medicine-knowledge%2Fbook-clinic%2FTextbook-of-Clinical-Researh%2F013-084.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-23"><span class="mw-cite-backlink"><a href="#cite_ref-23">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fineberg, NA; Brown, A; Reghunandanan, S; Pampaloni, I (2012). 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FDA<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">2015-01-30</span></span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Sertraline+prescribing+information&amp;rft.pub=FDA&amp;rft_id=http%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Flabel%2F2009%2F019839s070%2C020990s032lbl.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><a href="#cite_ref-25">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.apotex.com/us/en/products/downloads/pil/paxil_irtb_ins.pdf">"Paroxetine prescribing information"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. 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Emedicinehealth.com. 23 September 2012<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">23 September</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=SSRIs+and+Depression&amp;rft.pub=Emedicinehealth.com&amp;rft.date=2012-09-23&amp;rft_id=http%3A%2F%2Fwww.emedicinehealth.com%2Fssris_and_depression%2Fpage5_em.htm&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-Bahrick-37"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Bahrick_37-0">37.0</a></sup> <sup><a href="#cite_ref-Bahrick_37-1">37.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFBahrick2008" class="citation journal cs1">Bahrick, Audrey (2008). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20131019115232/http://www.benthamscience.com/open/topsyj/articles/V001/42TOPSYJ.pdf">"Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence"</a> <span class="cs1-format">(PDF)</span>. <i>The Open Psychology Journal</i>. <b>1</b>: 42–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F1874350100801010042">10.2174/1874350100801010042</a>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.benthamscience.com/open/topsyj/articles/V001/42TOPSYJ.pdf">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 19 October 2013<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">2014-01-30</span></span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Open+Psychology+Journal&amp;rft.atitle=Persistence+of+Sexual+Dysfunction+Side+Effects+after+Discontinuation+of+Antidepressant+Medications%3A+Emerging+Evidence&amp;rft.volume=1&amp;rft.pages=42-50&amp;rft.date=2008&amp;rft_id=info%3Adoi%2F10.2174%2F1874350100801010042&amp;rft.aulast=Bahrick&amp;rft.aufirst=Audrey&amp;rft_id=http%3A%2F%2Fwww.benthamscience.com%2Fopen%2Ftopsyj%2Farticles%2FV001%2F42TOPSYJ.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-38"><span class="mw-cite-backlink"><a href="#cite_ref-38">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFTaylorRudkinBullemor-DayLubin2013" class="citation journal cs1">Taylor, MJ; Rudkin, L; Bullemor-Day, P; Lubin, J; Chukwujekwu, C; Hawton, K (31 May 2013). 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Lilly and Company. p.&#160;14.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Prozac&amp;rft.pages=14&amp;rft.pub=Lilly+and+Company&amp;rft_id=http%3A%2F%2Fpi.lilly.com%2Fus%2Fprozac.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-42"><span class="mw-cite-backlink"><a href="#cite_ref-42">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.researchgate.net/publication/262926791_One_hundred_and_twenty_cases_of_enduring_sexual_dysfunction_following_treatment">"One hundred and twenty cases of enduring sexual dysfunction following treatment"</a>. <i>ResearchGate</i>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3233%2FJRS-140617">10.3233/JRS-140617</a><span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">2016-01-30</span></span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=ResearchGate&amp;rft.atitle=One+hundred+and+twenty+cases+of+enduring+sexual+dysfunction+following+treatment&amp;rft_id=info%3Adoi%2F10.3233%2FJRS-140617&amp;rft_id=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F262926791_One_hundred_and_twenty_cases_of_enduring_sexual_dysfunction_following_treatment&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-43"><span class="mw-cite-backlink"><a href="#cite_ref-43">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFGitlin1994" class="citation journal cs1">Gitlin, M. 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"Antidepressant Use in Pregnancy and the Risk of Cardiac Defects". <i>New England Journal of Medicine</i>. <b>370</b> (25): 2397–2407. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1312828">10.1056/NEJMoa1312828</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a>&#160;<a rel="nofollow" class="external text" href="//www.worldcat.org/issn/0028-4793">0028-4793</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24941178">24941178</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=New+England+Journal+of+Medicine&amp;rft.atitle=Antidepressant+Use+in+Pregnancy+and+the+Risk+of+Cardiac+Defects&amp;rft.volume=370&amp;rft.issue=25&amp;rft.pages=2397-2407&amp;rft.date=2014&amp;rft.issn=0028-4793&amp;rft_id=info%3Apmid%2F24941178&amp;rft_id=info%3Adoi%2F10.1056%2FNEJMoa1312828&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-afpssri-51"><span class="mw-cite-backlink"><a href="#cite_ref-afpssri_51-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFGoldberg,_RJ1998" class="citation journal cs1">Goldberg, RJ (1998). <a rel="nofollow" class="external text" href="https://archive.today/20110623110238/http://archfami.ama-assn.org/cgi/pmidlookup?view=long&amp;pmid=9443704">"Selective serotonin reuptake inhibitors: infrequent medical adverse effects"</a>. <i>Archives of Family Medicine</i>. <b>7</b> (1): 78–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchfami.7.1.78">10.1001/archfami.7.1.78</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/9443704">9443704</a>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://archfami.ama-assn.org/cgi/pmidlookup?view=long&amp;pmid=9443704">แหล่งเดิม</a>เมื่อ 23 June 2011<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Archives+of+Family+Medicine&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors%3A+infrequent+medical+adverse+effects&amp;rft.volume=7&amp;rft.issue=1&amp;rft.pages=78-84&amp;rft.date=1998&amp;rft_id=info%3Adoi%2F10.1001%2Farchfami.7.1.78&amp;rft_id=info%3Apmid%2F9443704&amp;rft.au=Goldberg%2C+RJ&amp;rft_id=http%3A%2F%2Farchfami.ama-assn.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D9443704&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-52"><span class="mw-cite-backlink"><a href="#cite_ref-52">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.fda.gov/Drugs/DrugSafety/ucm269086.htm">"FDA Drug Safety"</a>. FDA.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=FDA+Drug+Safety&amp;rft.pub=FDA&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2FDrugs%2FDrugSafety%2Fucm269086.htm&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-53"><span class="mw-cite-backlink"><a href="#cite_ref-53">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON137769">"Citalopram and escitalopram: QT interval prolongation—new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings"</a>. Medicines and Healthcare Products Regulatory Agency. December 2011.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Citalopram+and+escitalopram%3A+QT+interval+prolongation%E2%80%94new+maximum+daily+dose+restrictions+%28including+in+elderly+patients%29%2C+contraindications%2C+and+warnings&amp;rft.pub=Medicines+and+Healthcare+Products+Regulatory+Agency&amp;rft.date=2011-12&amp;rft_id=http%3A%2F%2Fwww.mhra.gov.uk%2FSafetyinformation%2FDrugSafetyUpdate%2FCON137769&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-54"><span class="mw-cite-backlink"><a href="#cite_ref-54">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://m.utoledo.edu/med/gme/em/pdfs/ECG_escitalopram.pdf">"ref2"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span><span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">23 September</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=ref2&amp;rft_id=http%3A%2F%2Fm.utoledo.edu%2Fmed%2Fgme%2Fem%2Fpdfs%2FECG_escitalopram.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-55"><span class="mw-cite-backlink"><a href="#cite_ref-55">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Pacher, P; Ungvari, Z; Nanasi, PP; Furst, S; Kecskemeti, V (June 1999). 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Is there any?". <i>Current medicinal chemistry</i>. <b>6</b> (6): 469–80. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/10213794">10213794</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Current+medicinal+chemistry&amp;rft.atitle=Speculations+on+difference+between+tricyclic+and+selective+serotonin+reuptake+inhibitor+antidepressants+on+their+cardiac+effects.+Is+there+any%3F&amp;rft.volume=6&amp;rft.issue=6&amp;rft.pages=469-80&amp;rft.date=1999-06&amp;rft_id=info%3Apmid%2F10213794&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Wein2005-56"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Wein2005_56-0">56.0</a></sup> <sup><a href="#cite_ref-Wein2005_56-1">56.1</a></sup></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Weinrieb, RM; Auriacombe, M; Lynch, KG; Lewis, JD (March 2005). "Selective serotonin re-uptake inhibitors and the risk of bleeding". <i>Expert Opinion on Drug Safety</i>. <b>4</b> (2): 337–44. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F14740338.4.2.337">10.1517/14740338.4.2.337</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/15794724">15794724</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Expert+Opinion+on+Drug+Safety&amp;rft.atitle=Selective+serotonin+re-uptake+inhibitors+and+the+risk+of+bleeding&amp;rft.volume=4&amp;rft.issue=2&amp;rft.pages=337-44&amp;rft.date=2005-03&amp;rft_id=info%3Adoi%2F10.1517%2F14740338.4.2.337&amp;rft_id=info%3Apmid%2F15794724&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Maudsley-57"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Maudsley_57-0">57.0</a></sup> <sup><a href="#cite_ref-Maudsley_57-1">57.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFTaylorCarolShitij2012" class="citation book cs1">Taylor, D; Carol, P; Shitij, K (2012). <a rel="nofollow" class="external text" href="https://archive.org/details/maudsleyprescrib0000tayl_r0f4_11thed"><i>The Maudsley prescribing guidelines in psychiatry</i></a>. West Sussex: Wiley-Blackwell. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/9780470979693" title="พิเศษ:แหล่งหนังสือ/9780470979693"><bdi>9780470979693</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=The+Maudsley+prescribing+guidelines+in+psychiatry&amp;rft.place=West+Sussex&amp;rft.pub=Wiley-Blackwell&amp;rft.date=2012&amp;rft.isbn=9780470979693&amp;rft.aulast=Taylor&amp;rft.aufirst=D&amp;rft.au=Carol%2C+P&amp;rft.au=Shitij%2C+K&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fmaudsleyprescrib0000tayl_r0f4_11thed&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-pmid21190637-58"><span class="mw-cite-backlink"><a href="#cite_ref-pmid21190637_58-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Andrade, C; Sandarsh, S; Chethan, KB; Nagesh, KS (December 2010). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-clinical-psychiatry_2010-12_71_12/page/1565">"Serotonin Reuptake Inhibitor Antidepressants and Abnormal Bleeding: A Review for Clinicians and a Reconsideration of Mechanisms"</a>. <i>The Journal of Clinical Psychiatry</i>. <b>71</b> (12): 1565–1575. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4088%2FJCP.09r05786blu">10.4088/JCP.09r05786blu</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/21190637">21190637</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Journal+of+Clinical+Psychiatry&amp;rft.atitle=Serotonin+Reuptake+Inhibitor+Antidepressants+and+Abnormal+Bleeding%3A+A+Review+for+Clinicians+and+a+Reconsideration+of+Mechanisms&amp;rft.volume=71&amp;rft.issue=12&amp;rft.pages=1565-1575&amp;rft.date=2010-12&amp;rft_id=info%3Adoi%2F10.4088%2FJCP.09r05786blu&amp;rft_id=info%3Apmid%2F21190637&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-clinical-psychiatry_2010-12_71_12%2Fpage%2F1565&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-NSAIDs-59"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-NSAIDs_59-0">59.0</a></sup> <sup><a href="#cite_ref-NSAIDs_59-1">59.1</a></sup></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">de Abajo, FJ; García-Rodríguez, LA (July 2008). "Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents". <i>Archives of General Psychiatry</i>. <b>65</b> (7): 795–803. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchpsyc.65.7.795">10.1001/archpsyc.65.7.795</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18606952">18606952</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Archives+of+General+Psychiatry&amp;rft.atitle=Risk+of+upper+gastrointestinal+tract+bleeding+associated+with+selective+serotonin+reuptake+inhibitors+and+venlafaxine+therapy%3A+interaction+with+nonsteroidal+anti-inflammatory+drugs+and+effect+of+acid-suppressing+agents&amp;rft.volume=65&amp;rft.issue=7&amp;rft.pages=795-803&amp;rft.date=2008-07&amp;rft_id=info%3Adoi%2F10.1001%2Farchpsyc.65.7.795&amp;rft_id=info%3Apmid%2F18606952&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-pmid23077009-60"><span class="mw-cite-backlink"><a href="#cite_ref-pmid23077009_60-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Hackam, DG; Mrkobrada, M (2012). "Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis". <i>Neurology</i>. <b>79</b> (18): 1862–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1212%2FWNL.0b013e318271f848">10.1212/WNL.0b013e318271f848</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23077009">23077009</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Neurology&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors+and+brain+hemorrhage%3A+a+meta-analysis&amp;rft.volume=79&amp;rft.issue=18&amp;rft.pages=1862-5&amp;rft.date=2012&amp;rft_id=info%3Adoi%2F10.1212%2FWNL.0b013e318271f848&amp;rft_id=info%3Apmid%2F23077009&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-61"><span class="mw-cite-backlink"><a href="#cite_ref-61">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFSerebruany,_VL2006" class="citation journal cs1">Serebruany, VL (February 2006). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_american-journal-of-medicine_2006-02_119_2/page/113">"Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?"</a>. <i>The American Journal of Medicine</i>. <b>119</b> (2): 113–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.amjmed.2005.03.044">10.1016/j.amjmed.2005.03.044</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/16443409">16443409</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+American+Journal+of+Medicine&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors+and+increased+bleeding+risk%3A+are+we+missing+something%3F&amp;rft.volume=119&amp;rft.issue=2&amp;rft.pages=113-6&amp;rft.date=2006-02&amp;rft_id=info%3Adoi%2F10.1016%2Fj.amjmed.2005.03.044&amp;rft_id=info%3Apmid%2F16443409&amp;rft.au=Serebruany%2C+VL&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_american-journal-of-medicine_2006-02_119_2%2Fpage%2F113&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-62"><span class="mw-cite-backlink"><a href="#cite_ref-62">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Halperin, D; Reber, G (2007). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3181838">"Influence of antidepressants on hemostasis"</a>. <i>Dialogues in Clinical Neuroscience</i>. <b>9</b> (1): 47–59. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3181838">3181838</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17506225">17506225</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Dialogues+in+Clinical+Neuroscience&amp;rft.atitle=Influence+of+antidepressants+on+hemostasis&amp;rft.volume=9&amp;rft.issue=1&amp;rft.pages=47-59&amp;rft.date=2007&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3181838%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F17506225&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3181838&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-63"><span class="mw-cite-backlink"><a href="#cite_ref-63">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Andrade, C; Sandarsh, S; Chethan, KB; Nagesh, KS (2010). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-clinical-psychiatry_2010-12_71_12/page/1565">"Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms"</a>. <i>The Journal of Clinical Psychiatry</i>. <b>71</b> (12): 1565–75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4088%2FJCP.09r05786blu">10.4088/JCP.09r05786blu</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/21190637">21190637</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Journal+of+Clinical+Psychiatry&amp;rft.atitle=Serotonin+reuptake+inhibitor+antidepressants+and+abnormal+bleeding%3A+a+review+for+clinicians+and+a+reconsideration+of+mechanisms&amp;rft.volume=71&amp;rft.issue=12&amp;rft.pages=1565-75&amp;rft.date=2010&amp;rft_id=info%3Adoi%2F10.4088%2FJCP.09r05786blu&amp;rft_id=info%3Apmid%2F21190637&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-clinical-psychiatry_2010-12_71_12%2Fpage%2F1565&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-64"><span class="mw-cite-backlink"><a href="#cite_ref-64">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFde_Abajo,_FJ2011" class="citation journal cs1">de Abajo, FJ (2011). 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APA Practice Guidelines &#124; Practice Guideline for the Treatment of Patients With Major Depressive Disorder,"</a> (3rd&#160;ed.). คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://psychiatryonline.org/content.aspx?bookID=28&amp;sectionID=1667485#655181">แหล่งเดิม</a>เมื่อ 19 February 2014<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=PsychiatryOnline+%26%23124%3B+APA+Practice+Guidelines+%26%23124%3B+Practice+Guideline+for+the+Treatment+of+Patients+With+Major+Depressive+Disorder%2C&amp;rft.edition=3rd&amp;rft_id=http%3A%2F%2Fpsychiatryonline.org%2Fcontent.aspx%3FbookID%3D28%26sectionID%3D1667485%23655181&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-66"><span class="mw-cite-backlink"><a href="#cite_ref-66">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFRenoir,_T2013" class="citation journal cs1">Renoir, T (2013). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3627130">"Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved"</a>. <i>Frontiers in Pharmacology</i>. <b>4</b>: 45. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffphar.2013.00045">10.3389/fphar.2013.00045</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3627130">3627130</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23596418">23596418</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Frontiers+in+Pharmacology&amp;rft.atitle=Selective+serotonin+reuptake+inhibitor+antidepressant+treatment+discontinuation+syndrome%3A+a+review+of+the+clinical+evidence+and+the+possible+mechanisms+involved&amp;rft.volume=4&amp;rft.pages=45&amp;rft.date=2013&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3627130%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F23596418&amp;rft_id=info%3Adoi%2F10.3389%2Ffphar.2013.00045&amp;rft.au=Renoir%2C+T&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3627130&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-FDA2-67"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-FDA2_67-0">67.0</a></sup> <sup><a href="#cite_ref-FDA2_67-1">67.1</a></sup></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1">Stone, MB; Jones, ML (17 November 2006). <a rel="nofollow" class="external text" href="http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-FDA.pdf">"Clinical review: relationship between antidepressant drugs and suicidal behavior in adults"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. <i>Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)</i>. FDA. pp.&#160;11–74<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">22 September</span> 2007</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Overview+for+December+13+Meeting+of+Psychopharmacologic+Drugs+Advisory+Committee+%28PDAC%29&amp;rft.atitle=Clinical+review%3A+relationship+between+antidepressant+drugs+and+suicidal+behavior+in+adults&amp;rft.pages=11-74&amp;rft.date=2006-11-17&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2Fohrms%2Fdockets%2Fac%2F06%2Fbriefing%2F2006-4272b1-01-FDA.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_web" title="แม่แบบ:Cite web">cite web</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-FDA3-68"><span class="mw-cite-backlink"><a href="#cite_ref-FDA3_68-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1">Levenson, M; Holland, C (17 November 2006). <a rel="nofollow" class="external text" href="http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-FDA.pdf">"Statistical Evaluation of Suicidality in Adults Treated with Antidepressants"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. <i>Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)</i>. FDA. pp.&#160;75–140<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">22 September</span> 2007</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Overview+for+December+13+Meeting+of+Psychopharmacologic+Drugs+Advisory+Committee+%28PDAC%29&amp;rft.atitle=Statistical+Evaluation+of+Suicidality+in+Adults+Treated+with+Antidepressants&amp;rft.pages=75-140&amp;rft.date=2006-11-17&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2Fohrms%2Fdockets%2Fac%2F06%2Fbriefing%2F2006-4272b1-01-FDA.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_web" title="แม่แบบ:Cite web">cite web</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Olfson-69"><span class="mw-cite-backlink"><a href="#cite_ref-Olfson_69-0">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Olfson, M; Marcus, SC; Shaffer, D (August 2006). 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FDA. pp.&#160;42, 115<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">29 May</span> 2008</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Review+and+evaluation+of+clinical+data.+Relationship+between+psychiatric+drugs+and+pediatric+suicidal+behavior&amp;rft.pages=42%2C+115&amp;rft.pub=FDA&amp;rft.date=2004-08-16&amp;rft.au=Hammad%2C+TA&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2FOHRMS%2FDOCKETS%2Fac%2F04%2Fbriefing%2F2004-4065b1-10-TAB08-Hammads-Review.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-71"><span class="mw-cite-backlink"><a href="#cite_ref-71">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.fda.gov/drugs/drugsafety/informationbydrugclass/ucm096273">"Antidepressant Use in Children, Adolescents, and Adults"</a>. <i>FDA</i>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=FDA&amp;rft.atitle=Antidepressant+Use+in+Children%2C+Adolescents%2C+and+Adults&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fdrugsafety%2Finformationbydrugclass%2Fucm096273&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-72"><span class="mw-cite-backlink"><a href="#cite_ref-72">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.fda.gov/downloads/Drugs/DrugSafety/ucm088660.pdf%E2%80%8E">"FDA Medication Guide for Antidepressants"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span><span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">5 June</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=FDA+Medication+Guide+for+Antidepressants&amp;rft_id=http%3A%2F%2Fwww.fda.gov%2Fdownloads%2FDrugs%2FDrugSafety%2Fucm088660.pdf%25E2%2580%258E&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-pmid23152255-73"><span class="mw-cite-backlink"><a href="#cite_ref-pmid23152255_73-0">↑</a></span> <span class="reference-text"> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25433518">update version</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Cox, GR; Callahan, P; Churchill, R; Hunot, V; Merry, SN; Parker, AG; Hetrick, SE (2012). 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NICE. 28 October 2009. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="https://www.nice.org.uk/guidance/cg90/resources/depression-in-adults-recognition-and-management-975742636741">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 3 November 2015<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Depression+in+adults%3A+recognition+and+Depression+in+adults%3A+recognition+and+management+management+%28CG90%29&amp;rft.pub=NICE&amp;rft.date=2009-10-28&amp;rft_id=https%3A%2F%2Fwww.nice.org.uk%2Fguidance%2Fcg90%2Fresources%2Fdepression-in-adults-recognition-and-management-975742636741&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-75"><span class="mw-cite-backlink"><a href="#cite_ref-75">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25433518">Update version</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Cox, GR; Callahan, P; Churchill, R; Hunot, V; Merry, SN; Parker, AG; Hetrick, SE (2012). "Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents". <i>Cochrane Database Syst Rev</i>. <b>11</b>: CD008324. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD008324.pub2">10.1002/14651858.CD008324.pub2</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23152255">23152255</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Cochrane+Database+Syst+Rev&amp;rft.atitle=Psychological+therapies+versus+antidepressant+medication%2C+alone+and+in+combination+for+depression+in+children+and+adolescents&amp;rft.volume=11&amp;rft.pages=CD008324&amp;rft.date=2012&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD008324.pub2&amp;rft_id=info%3Apmid%2F23152255&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-76"><span class="mw-cite-backlink"><a href="#cite_ref-76">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1089%2Fcap.2006.0138">10.1089/cap.2006.0138</a><br /><span class="plainlinks nourlexpansion">This citation will be automatically completed in the next few minutes. <small>You can <a rel="nofollow" class="external text" href="http://toolserver.org/~verisimilus/Bot/DOI_bot/doibot.php?doi=10.1089%2Fcap.2006.0138">jump the queue</a> or <a class="external text" href="https://th.wikipedia.org/w/index.php?title=%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_doi/10.1089/cap.2006.0138&amp;preload=Template:Cite_doi/preload&amp;editintro=Template:Cite_doi/editintro&amp;action=edit">expand by hand</a></small></span></span> </li> <li id="cite_note-pmid17074941-77"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17074941_77-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gibbons, RD; Hur, K; Bhaumik, DK; Mann, JJ (November 2006). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_american-journal-of-psychiatry_2006-11_163_11/page/1898">"The relationship between antidepressant prescription rates and rate of early adolescent suicide"</a>. <i>The American Journal of Psychiatry</i>. <b>163</b> (11): 1898–904. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1176%2Fappi.ajp.163.11.1898">10.1176/appi.ajp.163.11.1898</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17074941">17074941</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+American+Journal+of+Psychiatry&amp;rft.atitle=The+relationship+between+antidepressant+prescription+rates+and+rate+of+early+adolescent+suicide&amp;rft.volume=163&amp;rft.issue=11&amp;rft.pages=1898-904&amp;rft.date=2006-11&amp;rft_id=info%3Adoi%2F10.1176%2Fappi.ajp.163.11.1898&amp;rft_id=info%3Apmid%2F17074941&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_american-journal-of-psychiatry_2006-11_163_11%2Fpage%2F1898&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-78"><span class="mw-cite-backlink"><a href="#cite_ref-78">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.mhra.gov.uk/home/groups/pl-p/documents/drugsafetymessage/con019472.pdf">"Report of the CSM expert working group on the safety of selective serotonin reuptake inhibitor antidepressants"</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>. Medicines and Healthcare products Regulatory Agency. 1 December 2004<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">25 September</span> 2007</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Report+of+the+CSM+expert+working+group+on+the+safety+of+selective+serotonin+reuptake+inhibitor+antidepressants&amp;rft.pub=Medicines+and+Healthcare+products+Regulatory+Agency&amp;rft.date=2004-12-01&amp;rft_id=http%3A%2F%2Fwww.mhra.gov.uk%2Fhome%2Fgroups%2Fpl-p%2Fdocuments%2Fdrugsafetymessage%2Fcon019472.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-MHRAoverview-79"><span class="mw-cite-backlink"><a href="#cite_ref-MHRAoverview_79-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://webarchive.nationalarchives.gov.uk/20141205150130/http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON019494">"Selective Serotonin Reuptake Inhibitors (SSRIs)&#160;: Overview of regulatory status and CSM advice relating to major depressive disorder (MDD) in children and adolescents including a summary of available safety and efficacy data"</a>. Medicines and Healthcare products Regulatory Agency. 29 September 2005. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON019494">แหล่งเดิม</a>เมื่อ 5 December 2014<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">29 May</span> 2008</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Selective+Serotonin+Reuptake+Inhibitors+%28SSRIs%29+%3A+Overview+of+regulatory+status+and+CSM+advice+relating+to+major+depressive+disorder+%28MDD%29+in+children+and+adolescents+including+a+summary+of+available+safety+and+efficacy+data&amp;rft.pub=Medicines+and+Healthcare+products+Regulatory+Agency&amp;rft.date=2005-09-29&amp;rft_id=http%3A%2F%2Fwww.mhra.gov.uk%2FSafetyinformation%2FSafetywarningsalertsandrecalls%2FSafetywarningsandmessagesformedicines%2FCON019494&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-80"><span class="mw-cite-backlink"><a href="#cite_ref-80">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gunnell, D; Saperia, J; Ashby, D (February 2005). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC549105">"Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review"</a>. <i>BMJ</i> (Clinical Research&#160;ed.). <b>330</b> (7488): 385. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.330.7488.385">10.1136/bmj.330.7488.385</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC549105">549105</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/15718537">15718537</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=BMJ&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors+%28SSRIs%29+and+suicide+in+adults%3A+meta-analysis+of+drug+company+data+from+placebo+controlled%2C+randomised+controlled+trials+submitted+to+the+MHRA%27s+safety+review&amp;rft.volume=330&amp;rft.issue=7488&amp;rft.pages=385&amp;rft.date=2005-02&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC549105%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F15718537&amp;rft_id=info%3Adoi%2F10.1136%2Fbmj.330.7488.385&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC549105&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-81"><span class="mw-cite-backlink"><a href="#cite_ref-81">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fergusson, D; Doucette, S; Glass, KC; Shapiro, S; Healy, D; Hebert, P; Hutton, B (February 2005). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC549110">"Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials"</a>. <i>BMJ (Clinical Research Ed.)</i>. <b>330</b> (7488): 396. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.330.7488.396">10.1136/bmj.330.7488.396</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC549110">549110</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/15718539">15718539</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=BMJ+%28Clinical+Research+Ed.%29&amp;rft.atitle=Association+between+suicide+attempts+and+selective+serotonin+reuptake+inhibitors%3A+systematic+review+of+randomised+controlled+trials&amp;rft.volume=330&amp;rft.issue=7488&amp;rft.pages=396&amp;rft.date=2005-02&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC549110%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F15718539&amp;rft_id=info%3Adoi%2F10.1136%2Fbmj.330.7488.396&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC549110&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-82"><span class="mw-cite-backlink"><a href="#cite_ref-82">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Rihmer, Z; Akiskal, H (August 2006). "Do antidepressants t(h) reat (en) depressives? Toward a clinically judicious formulation of the antidepressant-suicidality FDA advisory in light of declining national suicide statistics from many countries". <i>Journal of Affective Disorders</i>. <b>94</b> (1–3): 3–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jad.2006.04.003">10.1016/j.jad.2006.04.003</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/16712945">16712945</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Affective+Disorders&amp;rft.atitle=Do+antidepressants+t%28h%29+reat+%28en%29+depressives%3F+Toward+a+clinically+judicious+formulation+of+the+antidepressant-suicidality+FDA+advisory+in+light+of+declining+national+suicide+statistics+from+many+countries&amp;rft.volume=94&amp;rft.issue=1%E2%80%933&amp;rft.pages=3-13&amp;rft.date=2006-08&amp;rft_id=info%3Adoi%2F10.1016%2Fj.jad.2006.04.003&amp;rft_id=info%3Apmid%2F16712945&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-83"><span class="mw-cite-backlink"><a href="#cite_ref-83">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Hall, WD; Lucke, J (2006). "How have the selective serotonin reuptake inhibitor antidepressants affected suicide mortality?". <i>The Australian and New Zealand Journal of Psychiatry</i>. <b>40</b> (11–12): 941–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1440-1614.2006.01917.x">10.1111/j.1440-1614.2006.01917.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17054562">17054562</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Australian+and+New+Zealand+Journal+of+Psychiatry&amp;rft.atitle=How+have+the+selective+serotonin+reuptake+inhibitor+antidepressants+affected+suicide+mortality%3F&amp;rft.volume=40&amp;rft.issue=11%E2%80%9312&amp;rft.pages=941-50&amp;rft.date=2006&amp;rft_id=info%3Adoi%2F10.1111%2Fj.1440-1614.2006.01917.x&amp;rft_id=info%3Apmid%2F17054562&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-84"><span class="mw-cite-backlink"><a href="#cite_ref-84">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFMalm,_H2012" class="citation journal cs1">Malm, H (December 2012). "Prenatal exposure to selective serotonin reuptake inhibitors and infant outcome". <i>Therapeutic Drug Monitoring</i>. <b>34</b> (6): 607–14. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FFTD.0b013e31826d07ea">10.1097/FTD.0b013e31826d07ea</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23042258">23042258</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Therapeutic+Drug+Monitoring&amp;rft.atitle=Prenatal+exposure+to+selective+serotonin+reuptake+inhibitors+and+infant+outcome&amp;rft.volume=34&amp;rft.issue=6&amp;rft.pages=607-14&amp;rft.date=2012-12&amp;rft_id=info%3Adoi%2F10.1097%2FFTD.0b013e31826d07ea&amp;rft_id=info%3Apmid%2F23042258&amp;rft.au=Malm%2C+H&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-85"><span class="mw-cite-backlink"><a href="#cite_ref-85">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Rahimi, R; Nikfar, S; Abdollahi, M (2006). 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Rahimi, R; Hendoiee, N; Abdollahi, M (2012). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3556001">"Increasing the risk of spontaneous abortion and major malformations in newborns following use of serotonin reuptake inhibitors during pregnancy: A systematic review and updated meta-analysis"</a>. <i>Daru&#160;: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences</i>. <b>20</b> (1): 75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F2008-2231-20-75">10.1186/2008-2231-20-75</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3556001">3556001</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23351929">23351929</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Daru+%3A+Journal+of+Faculty+of+Pharmacy%2C+Tehran+University+of+Medical+Sciences&amp;rft.atitle=Increasing+the+risk+of+spontaneous+abortion+and+major+malformations+in+newborns+following+use+of+serotonin+reuptake+inhibitors+during+pregnancy%3A+A+systematic+review+and+updated+meta-analysis&amp;rft.volume=20&amp;rft.issue=1&amp;rft.pages=75&amp;rft.date=2012&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3556001%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F23351929&amp;rft_id=info%3Adoi%2F10.1186%2F2008-2231-20-75&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3556001&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-87"><span class="mw-cite-backlink"><a href="#cite_ref-87">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1176%2Fappi.ajp.2015.14121575">10.1176/appi.ajp.2015.14121575</a><br /><span class="plainlinks nourlexpansion">This citation will be automatically completed in the next few minutes. <small>You can <a rel="nofollow" class="external text" href="http://toolserver.org/~verisimilus/Bot/DOI_bot/doibot.php?doi=10.1176%2Fappi.ajp.2015.14121575">jump the queue</a> or <a class="external text" href="https://th.wikipedia.org/w/index.php?title=%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_doi/10.1176/appi.ajp.2015.14121575&amp;preload=Template:Cite_doi/preload&amp;editintro=Template:Cite_doi/editintro&amp;action=edit">expand by hand</a></small></span> <span class="PDFlink"><a rel="nofollow" class="external text" href="http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2015.14121575">Full Article</a></span><span style="font-size:smaller;"><a href="/wiki/Portable_Document_Format" class="mw-redirect" title="Portable Document Format">PDF</a>&#160;(556&#160;KB)</span> </span> </li> <li id="cite_note-88"><span class="mw-cite-backlink"><a href="#cite_ref-88">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Einarson, TR; Kennedy, D; Einarson, A (2012). 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The case of antidepressant use in pregnancy and malformations". <i>Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Thérapeutique Des Populations Et De La Pharamcologie Clinique</i>. <b>19</b> (2): e334-48. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22946124">22946124</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Population+Therapeutics+and+Clinical+Pharmacology+%3D+Journal+De+La+Th%C3%A9rapeutique+Des+Populations+Et+De+La+Pharamcologie+Clinique&amp;rft.atitle=Do+findings+differ+across+research+design%3F+The+case+of+antidepressant+use+in+pregnancy+and+malformations&amp;rft.volume=19&amp;rft.issue=2&amp;rft.pages=e334-48&amp;rft.date=2012&amp;rft_id=info%3Apmid%2F22946124&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-89"><span class="mw-cite-backlink"><a href="#cite_ref-89">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Riggin, L; Frankel, Z; Moretti, M; Pupco, A; Koren, G (April 2013). "The fetal safety of fluoxetine: a systematic review and meta-analysis". <i>Journal of Obstetrics and Gynaecology Canada&#160;: JOGC = Journal D'obstétrique Et Gynécologie Du Canada&#160;: JOGC</i>. <b>35</b> (4): 362–9. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23660045">23660045</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Obstetrics+and+Gynaecology+Canada+%3A+JOGC+%3D+Journal+D%27obst%C3%A9trique+Et+Gyn%C3%A9cologie+Du+Canada+%3A+JOGC&amp;rft.atitle=The+fetal+safety+of+fluoxetine%3A+a+systematic+review+and+meta-analysis&amp;rft.volume=35&amp;rft.issue=4&amp;rft.pages=362-9&amp;rft.date=2013-04&amp;rft_id=info%3Apmid%2F23660045&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-90"><span class="mw-cite-backlink"><a href="#cite_ref-90">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Koren, G; Nordeng, HM (February 2013). "Selective serotonin reuptake inhibitors and malformations: case closed?". <i>Seminars in Fetal &amp; Neonatal Medicine</i>. <b>18</b> (1): 19–22. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.siny.2012.10.004">10.1016/j.siny.2012.10.004</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23228547">23228547</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Seminars+in+Fetal+%26+Neonatal+Medicine&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors+and+malformations%3A+case+closed%3F&amp;rft.volume=18&amp;rft.issue=1&amp;rft.pages=19-22&amp;rft.date=2013-02&amp;rft_id=info%3Adoi%2F10.1016%2Fj.siny.2012.10.004&amp;rft_id=info%3Apmid%2F23228547&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-91"><span class="mw-cite-backlink"><a href="#cite_ref-91">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090225110030/http://breastfeeding.org/newsletter/v2i4/page2.html">"Breastfeeding Update: SDCBC's quarterly newsletter"</a>. Breastfeeding.org. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.breastfeeding.org/newsletter/v2i4/page2.html">แหล่งเดิม</a>เมื่อ 25 February 2009<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">10 July</span> 2010</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Breastfeeding+Update%3A+SDCBC%27s+quarterly+newsletter&amp;rft.pub=Breastfeeding.org&amp;rft_id=http%3A%2F%2Fwww.breastfeeding.org%2Fnewsletter%2Fv2i4%2Fpage2.html&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-92"><span class="mw-cite-backlink"><a href="#cite_ref-92">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20100923205146/http://kellymom.com/health/meds/antidepressants-hale10-02.html">"Using Antidepressants in Breastfeeding Mothers"</a>. kellymom.com. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.kellymom.com/health/meds/antidepressants-hale10-02.html">แหล่งเดิม</a>เมื่อ 23 September 2010<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">10 July</span> 2010</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Using+Antidepressants+in+Breastfeeding+Mothers&amp;rft.pub=kellymom.com&amp;rft_id=http%3A%2F%2Fwww.kellymom.com%2Fhealth%2Fmeds%2Fantidepressants-hale10-02.html&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-93"><span class="mw-cite-backlink"><a href="#cite_ref-93">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gentile, S; Rossi, A; Bellantuono, C (2007). "SSRIs during breastfeeding: spotlight on milk-to-plasma ratio". <i>Archives of Women's Mental Health</i>. <b>10</b> (2): 39–51. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00737-007-0173-0">10.1007/s00737-007-0173-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17294355">17294355</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Archives+of+Women%27s+Mental+Health&amp;rft.atitle=SSRIs+during+breastfeeding%3A+spotlight+on+milk-to-plasma+ratio&amp;rft.volume=10&amp;rft.issue=2&amp;rft.pages=39-51&amp;rft.date=2007&amp;rft_id=info%3Adoi%2F10.1007%2Fs00737-007-0173-0&amp;rft_id=info%3Apmid%2F17294355&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-94"><span class="mw-cite-backlink"><a href="#cite_ref-94">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Fenger-Grøn, J; Thomsen, M; Andersen, KS; Nielsen, RG (September 2011). 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Medscape.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Persistent+Newborn+Pulmonary+Hypertension&amp;rft.pub=Medscape&amp;rft_id=http%3A%2F%2Femedicine.medscape.com%2Farticle%2F898437-overview%23aw2aab6b3&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-97"><span class="mw-cite-backlink"><a href="#cite_ref-97">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Grigoriadis, S; Vonderporten, EH; Mamisashvili, L; Tomlinson, G; Dennis, CL; Koren, G; Steiner, M; Mousmanis, P; Cheung, A; Ross, LE (2014). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3898424">"Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis"</a>. <i>BMJ (Clinical Research Ed.)</i>. <b>348</b>: f6932. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.f6932">10.1136/bmj.f6932</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3898424">3898424</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24429387">24429387</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=BMJ+%28Clinical+Research+Ed.%29&amp;rft.atitle=Prenatal+exposure+to+antidepressants+and+persistent+pulmonary+hypertension+of+the+newborn%3A+systematic+review+and+meta-analysis&amp;rft.volume=348&amp;rft.pages=f6932&amp;rft.date=2014&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3898424%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F24429387&amp;rft_id=info%3Adoi%2F10.1136%2Fbmj.f6932&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3898424&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-98"><span class="mw-cite-backlink"><a href="#cite_ref-98">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">GW, 't Jong; Einarson, T; Koren, G; Einarson, A (November 2012). "Antidepressant use in pregnancy and persistent pulmonary hypertension of the newborn (PPHN)&#160;: a systematic review". <i>Reproductive Toxicology (Elmsford, N.Y.)</i>. <b>34</b> (3): 293–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.reprotox.2012.04.015">10.1016/j.reprotox.2012.04.015</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22564982">22564982</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Reproductive+Toxicology+%28Elmsford%2C+N.Y.%29&amp;rft.atitle=Antidepressant+use+in+pregnancy+and+persistent+pulmonary+hypertension+of+the+newborn+%28PPHN%29+%3A+a+systematic+review&amp;rft.volume=34&amp;rft.issue=3&amp;rft.pages=293-7&amp;rft.date=2012-11&amp;rft_id=info%3Adoi%2F10.1016%2Fj.reprotox.2012.04.015&amp;rft_id=info%3Apmid%2F22564982&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-99"><span class="mw-cite-backlink"><a href="#cite_ref-99">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFGentile,_S2015" class="citation journal cs1">Gentile, S (2015). "Prenatal antidepressant exposure and the risk of autism spectrum disorders in children. Are we looking at the fall of Gods?". <i>J Affect Disord</i>. <b>182</b>: 132–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jad.2015.04.048">10.1016/j.jad.2015.04.048</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/25985383">25985383</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=J+Affect+Disord.&amp;rft.atitle=Prenatal+antidepressant+exposure+and+the+risk+of+autism+spectrum+disorders+in+children.+Are+we+looking+at+the+fall+of+Gods%3F&amp;rft.volume=182&amp;rft.pages=132-7&amp;rft.date=2015&amp;rft_id=info%3Adoi%2F10.1016%2Fj.jad.2015.04.048&amp;rft_id=info%3Apmid%2F25985383&amp;rft.au=Gentile%2C+S&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span> Epub 2015 May 6.</span> </li> <li id="cite_note-100"><span class="mw-cite-backlink"><a href="#cite_ref-100">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Hviid, A; Melbye, M; Pasternak, B (19 December 2013). <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMoa1301449">"Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism"</a>. <i>The New England Journal of Medicine</i>. <b>369</b> (25): 2406–2415. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1301449">10.1056/NEJMoa1301449</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24350950">24350950</a><span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">18 December</span> 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+New+England+Journal+of+Medicine&amp;rft.atitle=Use+of+selective+serotonin+reuptake+inhibitors+during+pregnancy+and+risk+of+autism&amp;rft.volume=369&amp;rft.issue=25&amp;rft.pages=2406-2415&amp;rft.date=2013-12-19&amp;rft_id=info%3Adoi%2F10.1056%2FNEJMoa1301449&amp;rft_id=info%3Apmid%2F24350950&amp;rft_id=http%3A%2F%2Fwww.nejm.org%2Fdoi%2Ffull%2F10.1056%2FNEJMoa1301449&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-Finland2016-101"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Finland2016_101-0">101.0</a></sup> <sup><a href="#cite_ref-Finland2016_101-1">101.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Malm, Heli; Brown, Alan S และคณะ (2016). 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McGraw Hill Professional. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/978-0071624428" title="พิเศษ:แหล่งหนังสือ/978-0071624428"><bdi>978-0071624428</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Goodman+and+Gilman%E2%80%99s+The+Pharmacological+Basis+of+Therapeutics&amp;rft.edition=12th&amp;rft.pub=McGraw+Hill+Professional&amp;rft.date=2010&amp;rft.isbn=978-0071624428&amp;rft.aulast=Brunton&amp;rft.aufirst=L&amp;rft.au=Chabner%2C+B&amp;rft.au=Knollman%2C+B&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-111"><span class="mw-cite-backlink"><a href="#cite_ref-111">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFCirauloShader,_RI2011" class="citation book cs1">Ciraulo, DA; Shader, RI (2011). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160807032015/http://link.springer.com/book/10.1007/978-1-60327-435-7/page/1"><i>Pharmacotherapy of Depression</i></a> (2nd&#160;ed.). Springer. p.&#160;49. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-1-60327-435-7">10.1007/978-1-60327-435-7</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/978-1-60327-435-7" title="พิเศษ:แหล่งหนังสือ/978-1-60327-435-7"><bdi>978-1-60327-435-7</bdi></a>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://link.springer.com/book/10.1007/978-1-60327-435-7/page/1">แหล่งเดิม</a>เมื่อ 7 August 2016<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Pharmacotherapy+of+Depression&amp;rft.pages=49&amp;rft.edition=2nd&amp;rft.pub=Springer&amp;rft.date=2011&amp;rft_id=info%3Adoi%2F10.1007%2F978-1-60327-435-7&amp;rft.isbn=978-1-60327-435-7&amp;rft.aulast=Ciraulo&amp;rft.aufirst=DA&amp;rft.au=Shader%2C+RI&amp;rft_id=http%3A%2F%2Flink.springer.com%2Fbook%2F10.1007%2F978-1-60327-435-7%2Fpage%2F1&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-112"><span class="mw-cite-backlink"><a href="#cite_ref-112">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFGoodmanBruntonChabnerKnollmann2001" class="citation book cs1">Goodman, Louis Sanford; Brunton, Laurence L.; Chabner, Bruce.; Knollmann, Björn C. (2001). <i>Goodman and Gilman's pharmacological basis of therapeutics</i>. New York: McGraw-Hill. pp.&#160;459–461. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/%E0%B8%9E%E0%B8%B4%E0%B9%80%E0%B8%A8%E0%B8%A9:%E0%B9%81%E0%B8%AB%E0%B8%A5%E0%B9%88%E0%B8%87%E0%B8%AB%E0%B8%99%E0%B8%B1%E0%B8%87%E0%B8%AA%E0%B8%B7%E0%B8%AD/0-07-162442-2" title="พิเศษ:แหล่งหนังสือ/0-07-162442-2"><bdi>0-07-162442-2</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Goodman+and+Gilman%27s+pharmacological+basis+of+therapeutics&amp;rft.place=New+York&amp;rft.pages=459-461&amp;rft.pub=McGraw-Hill&amp;rft.date=2001&amp;rft.isbn=0-07-162442-2&amp;rft.aulast=Goodman&amp;rft.aufirst=Louis+Sanford&amp;rft.au=Brunton%2C+Laurence+L.&amp;rft.au=Chabner%2C+Bruce.&amp;rft.au=Knollmann%2C+Bj%C3%B6rn+C.&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-Kolb_2006-113"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Kolb_2006_113-0">113.0</a></sup> <sup><a href="#cite_ref-Kolb_2006_113-1">113.1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation book cs1">Kolb, Bryan; Wishaw, Ian (2006). <i>An Introduction to Brain and Behavior</i>. New York: Worth Publishers.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=An+Introduction+to+Brain+and+Behavior&amp;rft.place=New+York&amp;rft.pub=Worth+Publishers&amp;rft.date=2006&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_book" title="แม่แบบ:Cite book">cite book</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-114"><span class="mw-cite-backlink"><a href="#cite_ref-114">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Rasmussen-Torvik, LJ; McAlpine, DD (2007). "Genetic screening for SSRI drug response among those with major depression: great promise and unseen perils". <i>Depression and Anxiety</i>. <b>24</b> (5): 350–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fda.20251">10.1002/da.20251</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17096399">17096399</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Depression+and+Anxiety&amp;rft.atitle=Genetic+screening+for+SSRI+drug+response+among+those+with+major+depression%3A+great+promise+and+unseen+perils&amp;rft.volume=24&amp;rft.issue=5&amp;rft.pages=350-7&amp;rft.date=2007&amp;rft_id=info%3Adoi%2F10.1002%2Fda.20251&amp;rft_id=info%3Apmid%2F17096399&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-115"><span class="mw-cite-backlink"><a href="#cite_ref-115">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Murphy, GM; Kremer, C; Rodrigues, HE; Schatzberg, AF (October 2003). <a rel="nofollow" class="external text" href="http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&amp;pmid=14514498">"Pharmacogenetics of antidepressant medication intolerance"</a>. <i>The American Journal of Psychiatry</i>. <b>160</b> (10): 1830–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1176%2Fappi.ajp.160.10.1830">10.1176/appi.ajp.160.10.1830</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/14514498">14514498</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+American+Journal+of+Psychiatry&amp;rft.atitle=Pharmacogenetics+of+antidepressant+medication+intolerance&amp;rft.volume=160&amp;rft.issue=10&amp;rft.pages=1830-5&amp;rft.date=2003-10&amp;rft_id=info%3Adoi%2F10.1176%2Fappi.ajp.160.10.1830&amp;rft_id=info%3Apmid%2F14514498&amp;rft_id=http%3A%2F%2Fajp.psychiatryonline.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D14514498&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-116"><span class="mw-cite-backlink"><a href="#cite_ref-116">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFAnderson,_IM2000" class="citation journal cs1">Anderson, IM (April 2000). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-affective-disorders_2000-04_58_1/page/19">"Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability"</a>. <i>Journal of Affective Disorders</i>. <b>58</b> (1): 19–36. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0165-0327%2899%2900092-0">10.1016/S0165-0327(99)00092-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/10760555">10760555</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Affective+Disorders&amp;rft.atitle=Selective+serotonin+reuptake+inhibitors+versus+tricyclic+antidepressants%3A+a+meta-analysis+of+efficacy+and+tolerability&amp;rft.volume=58&amp;rft.issue=1&amp;rft.pages=19-36&amp;rft.date=2000-04&amp;rft_id=info%3Adoi%2F10.1016%2FS0165-0327%2899%2900092-0&amp;rft_id=info%3Apmid%2F10760555&amp;rft.au=Anderson%2C+IM&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-affective-disorders_2000-04_58_1%2Fpage%2F19&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-pmid18199864-117"><span class="mw-cite-backlink"><a href="#cite_ref-pmid18199864_117-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Turner, EH; Matthews, AM; Linardatos, E; Tell, RA; Rosenthal, R (January 2008). "Selective publication of antidepressant trials and its influence on apparent efficacy". <i>The New England Journal of Medicine</i>. <b>358</b> (3): 252–60. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMsa065779">10.1056/NEJMsa065779</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18199864">18199864</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+New+England+Journal+of+Medicine&amp;rft.atitle=Selective+publication+of+antidepressant+trials+and+its+influence+on+apparent+efficacy&amp;rft.volume=358&amp;rft.issue=3&amp;rft.pages=252-60&amp;rft.date=2008-01&amp;rft_id=info%3Adoi%2F10.1056%2FNEJMsa065779&amp;rft_id=info%3Apmid%2F18199864&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-dhintrev-118"><span class="mw-cite-backlink"><a href="#cite_ref-dhintrev_118-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFHealy,_DAldred_G2005" class="citation journal cs1">Healy, D; Aldred G (2005). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20131021043728/http://www.davidhealy.org.php53-23.dfw1-1.websitetestlink.com/wp-content/uploads/2012/05/2005-Healy-Aldred-Antidepressants-and-Suicide1.pdf">"Antidepressant drug use and the risk of suicide"</a> <span class="cs1-format">(PDF)</span>. <i>International Review of Psychiatry</i>. <b>17</b>: 163–172. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F09540260500071624">10.1080/09540260500071624</a>. คลังข้อมูลเก่าเก็บจาก<a rel="nofollow" class="external text" href="http://www.davidhealy.org.php53-23.dfw1-1.websitetestlink.com/wp-content/uploads/2012/05/2005-Healy-Aldred-Antidepressants-and-Suicide1.pdf">แหล่งเดิม</a> <span class="cs1-format">(<a href="/wiki/PDF" class="mw-redirect" title="PDF">PDF</a>)</span>เมื่อ 21 October 2013<span class="reference-accessdate">. สืบค้นเมื่อ <span class="nowrap">1 September</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=International+Review+of+Psychiatry&amp;rft.atitle=Antidepressant+drug+use+and+the+risk+of+suicide&amp;rft.volume=17&amp;rft.pages=163-172&amp;rft.date=2005&amp;rft_id=info%3Adoi%2F10.1080%2F09540260500071624&amp;rft.au=Healy%2C+D&amp;rft.au=Aldred+G&amp;rft_id=http%3A%2F%2Fwww.davidhealy.org.php53-23.dfw1-1.websitetestlink.com%2Fwp-content%2Fuploads%2F2012%2F05%2F2005-Healy-Aldred-Antidepressants-and-Suicide1.pdf&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-119"><span class="mw-cite-backlink"><a href="#cite_ref-119">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite id="CITEREFLapierre,_YD2003" class="citation journal cs1">Lapierre, YD (September 2003). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC193980">"Suicidality with selective serotonin reuptake inhibitors: Valid claim?"</a>. <i>J Psychiatry Neurosci</i>. <b>28</b> (5): 340–7. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC193980">193980</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/14517577">14517577</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=J+Psychiatry+Neurosci&amp;rft.atitle=Suicidality+with+selective+serotonin+reuptake+inhibitors%3A+Valid+claim%3F&amp;rft.volume=28&amp;rft.issue=5&amp;rft.pages=340-7&amp;rft.date=2003-09&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC193980%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F14517577&amp;rft.au=Lapierre%2C+YD&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC193980&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span></span> </li> <li id="cite_note-120"><span class="mw-cite-backlink"><a href="#cite_ref-120">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Khan, A; Khan, S; Kolts, R; Brown, WA (2003). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12668373">"Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports"</a>. <i>Am J Psychiatry</i>. <b>160</b>: 790–2. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1176%2Fappi.ajp.160.4.790">10.1176/appi.ajp.160.4.790</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/12668373">12668373</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Am+J+Psychiatry.&amp;rft.atitle=Suicide+rates+in+clinical+trials+of+SSRIs%2C+other+antidepressants%2C+and+placebo%3A+analysis+of+FDA+reports.&amp;rft.volume=160&amp;rft.pages=790-2&amp;rft.date=2003&amp;rft_id=info%3Adoi%2F10.1176%2Fappi.ajp.160.4.790&amp;rft_id=info%3Apmid%2F12668373&amp;rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12668373&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-121"><span class="mw-cite-backlink"><a href="#cite_ref-121">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Kaizar, EE; Greenhouse, JB; Seltman, H; Kelleher, K (2006). 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A Bayesian meta-analysis". <i>Clin Trials</i>. <b>3</b> (2): 73–90, discussion 91-8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1191%2F1740774506cn139oa">10.1191/1740774506cn139oa</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/16773951">16773951</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Clin+Trials&amp;rft.atitle=Do+antidepressants+cause+suicidality+in+children%3F+A+Bayesian+meta-analysis&amp;rft.volume=3&amp;rft.issue=2&amp;rft.pages=73-90%2C+discussion+91-8&amp;rft.date=2006&amp;rft_id=info%3Adoi%2F10.1191%2F1740774506cn139oa&amp;rft_id=info%3Apmid%2F16773951&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> <li id="cite_note-122"><span class="mw-cite-backlink"><a href="#cite_ref-122">↑</a></span> <span class="reference-text"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r10205087"><cite class="citation journal cs1">Gibbons, RD; Brown, CH; Hur, K; Davis, J; Mann, JJ (June 2012). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3367101">"Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxine"</a>. <i>Arch. Gen. Psychiatry</i>. <b>69</b> (6): 580–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchgenpsychiatry.2011.2048">10.1001/archgenpsychiatry.2011.2048</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="cs1-lock-free" title="เข้าถึงได้ฟรี"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3367101">3367101</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22309973">22309973</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Arch.+Gen.+Psychiatry&amp;rft.atitle=Suicidal+thoughts+and+behavior+with+antidepressant+treatment%3A+reanalysis+of+the+randomized+placebo-controlled+studies+of+fluoxetine+and+venlafaxine&amp;rft.volume=69&amp;rft.issue=6&amp;rft.pages=580-7&amp;rft.date=2012-06&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3367101%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F22309973&amp;rft_id=info%3Adoi%2F10.1001%2Farchgenpsychiatry.2011.2048&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3367101&amp;rfr_id=info%3Asid%2Fth.wikipedia.org%3ASelective+serotonin+re-uptake+inhibitors" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/%E0%B9%81%E0%B8%A1%E0%B9%88%E0%B9%81%E0%B8%9A%E0%B8%9A:Cite_journal" title="แม่แบบ:Cite journal">cite journal</a>}}</code>: CS1 maint: uses authors parameter (<a href="/w/index.php?title=%E0%B8%AB%E0%B8%A1%E0%B8%A7%E0%B8%94%E0%B8%AB%E0%B8%A1%E0%B8%B9%E0%B9%88:CS1_maint:_uses_authors_parameter&amp;action=edit&amp;redlink=1" class="new" title="หมวดหมู่:CS1 maint: uses authors parameter (ไม่มีหน้านี้)">ลิงก์</a>)</span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="แหล่งข้อมูลอื่น"><span id=".E0.B9.81.E0.B8.AB.E0.B8.A5.E0.B9.88.E0.B8.87.E0.B8.82.E0.B9.89.E0.B8.AD.E0.B8.A1.E0.B8.B9.E0.B8.A5.E0.B8.AD.E0.B8.B7.E0.B9.88.E0.B8.99"></span>แหล่งข้อมูลอื่น</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Selective_serotonin_re-uptake_inhibitors&amp;action=edit&amp;section=30" title="แก้ไขส่วน: แหล่งข้อมูลอื่น"><span>แก้</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://pi.lilly.com/us/prozac.pdf">PROZAC Product/Prescribing Information</a> at Eli Lilly and Company</li> <li><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&amp;term=Serotonin+uptake+inhibitors">Serotonin uptake inhibitors</a> ใน<a href="/w/index.php?title=US_National_Library_of_Medicine&amp;action=edit&amp;redlink=1" class="new" title="US National Library of Medicine (ไม่มีหน้านี้)">หอสมุดแพทยศาสตร์แห่งชาติอเมริกัน</a> สำหรับ<a href="/wiki/%E0%B8%AB%E0%B8%B1%E0%B8%A7%E0%B8%82%E0%B9%89%E0%B8%AD%E0%B9%80%E0%B8%99%E0%B8%B7%E0%B9%89%E0%B8%AD%E0%B8%AB%E0%B8%B2%E0%B8%97%E0%B8%B2%E0%B8%87%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B9%81%E0%B8%9E%E0%B8%97%E0%B8%A2%E0%B9%8C" title="หัวข้อเนื้อหาทางการแพทย์">หัวข้อเนื้อหาทางการแพทย์</a> (MeSH)</li></ul> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐6dd864dd59‐7456l Cached time: 20241108171700 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.893 seconds Real time usage: 1.080 seconds Preprocessor visited node count: 6800/1000000 Post‐expand include size: 320456/2097152 bytes Template argument size: 2983/2097152 bytes Highest expansion depth: 16/100 Expensive parser function count: 8/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 424837/5000000 bytes Lua time usage: 0.493/10.000 seconds Lua memory usage: 6518535/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 904.906 1 -total 62.89% 569.067 1 แม่แบบ:รายการอ้างอิง 29.51% 267.006 80 แม่แบบ:Cite_journal 11.61% 105.095 8 แม่แบบ:Cite_book 9.92% 89.799 31 แม่แบบ:Cite_web 6.80% 61.536 1 แม่แบบ:Why 6.51% 58.936 1 แม่แบบ:Infobox_drug_class 6.05% 54.779 1 แม่แบบ:Fix 5.95% 53.849 1 แม่แบบ:Infobox 5.61% 50.744 1 แม่แบบ:ชื่ออังกฤษ --> <!-- Saved in parser cache with key thwiki:pcache:idhash:806364-0!canonical and timestamp 20241108171700 and revision id 11245463. 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