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<!DOCTYPE html> <html>  <head> <meta charset="UTF-8"> <meta http-equiv="Cache-Control" content="no-store"> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <title> KEGG PATHWAY: Biosynthesis of enediyne antibiotics </title> <link rel="stylesheet" href="/css/kegg.css" type="text/css" /> <link rel="stylesheet" href="/css/jquery-ui.css" /> <style type="text/css">  </style> <script src="/js/jquery-3.1.0.min.js"></script> <script src="/js/jquery-ui.js"></script> <script src="/js/jquery.balloon.min.js"></script> <script src="/js/lz-string.min.js"></script> <script src="/kegg-bin/get_data.cgi?data=0021&id=show_pathway.merged.js&v2.11"></script> <script type="text/javascript">  </script> </head> <body>  <h1 class="page-title"> <a href="/kegg/pathway.html"><img alt="KEGG" border="0" src="/Fig/bget/kegg3.gif" /></a>  Biosynthesis of enediyne antibiotics </h1>   <div class="nav"> [ <a href="/brite/query=01059&htext=br08901.keg&option=-a&node_proc=br08901_org&proc_enabled=rn&panel=collapse" id="navPathwayMenu">Pathway menu</a> | <a href="/entry/rn01059" id="navPathwayEntry">Pathway entry</a> | <a id="descLink" href="#description">Show description</a> | <a href="/kegg-bin/view_module_table?id=M00824+M00826+M00829+M00827+M00828+M00830+M00831+M00832+M00834+M00833+M00825" target="taxmap">Taxonomy mapping</a> | <a id="downloadMenu" href="#">Download</a> | <a href="javascript:void(window.open('/kegg/document/help_pathway.html','KEGG_Help','width=720,height=640'))">Help</a> ] <div id="description" class="hidden"> Enediyne natural products are potent antitumor antibiotics produced by a variety of Actinomycetes. Enediyne has a unique structure consisting of three building blocks: aromatic, sugar and enediyne core. The enediyne core contains two acetylenic groups conjugated to a double bond in a 9- or 10-membered ring, and it is synthesized by an iterative type I polyketide synthase and other tailoring proteins [MD:<a href="/module/M00824">M00824</a> <a href="/module/M00825">M00825</a>]. The 10-membered enediyne such as calicheamicin also contains an allylic trisulfide group, which acts as a trigger for diradical formation. This diagram shows the biosynthesis of C-1027, maduropeptin, neocarzinostatin, kedarcidin and calicheamicin. Some aromatic moieties are synthesized via iterative type I polyketide synthases, and others are derived from chorismate and aromatic amino acids such as tyrosine and azatyrosine [MD:<a href="/module/M00829">M00829</a> <a href="/module/M00830">M00830</a> <a href="/module/M00831">M00831</a> <a href="/module/M00834">M00834</a> <a href="/module/M00826">M00826</a> <a href="/module/M00827">M00827</a> <a href="/module/M00828">M00828</a> <a href="/module/M00832">M00832</a>]. Finally, the aromatic and sugar building blocks are attached to the enediyne core by acyltransferases, condensation enzymes and glucosyltransferases [MD:<a href="/module/M00833">M00833</a>]. </div>  <form name="selmenu" method="get"> <input type="button" id="changePathwayTypeButton" value="Change pathway type"> <input type="text" class="hidden" name="mapno" value="01059" /> <input type="text" class="hidden" id="scale" name="scale" value="1" /> <input type="text" class="hidden" id="displayNoColoringImage" name="nocolor" value="0" /> <input type="text" class="hidden" id="displayDescription" name="show_description" value="hide" /> <input type="text" class="hidden" id="displayControlPanel" name="show_module_list" value="show" /> <input type="text" class="hidden" id="clickableMode" name="clickable_mode" value="" /> <input type="text" class="hidden" name="module" value="" /> </form>  </div>   <div class="image-block" style="position:static;"> <img 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