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<!doctype html> <html><head> <title>KEGG PATHWAY: rn01059</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1740274041"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1740274041"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1740274041" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script>  </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg3.gif"></a></td><td>   </td><td><a name="pathway:rn01059"></a><font class="title3">PATHWAY: rn01059</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_pathway.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr3 w1"> <table width="650" class="w2"> <tr><th class="th30 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td30 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">rn01059                     Pathway                                <br> </span></code></td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td31 defd"><div class="cel">Biosynthesis of enediyne antibiotics</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Description</span></th> <td class="td30 defd"><div class="cel">Enediyne natural products are potent antitumor antibiotics produced by a variety of Actinomycetes. Enediyne has a unique structure consisting of three building blocks: aromatic, sugar and enediyne core. The enediyne core contains two acetylenic groups conjugated to a double bond in a 9- or 10-membered ring, and it is synthesized by an iterative type I polyketide synthase and other tailoring proteins [MD:<a href="/module/M00824">M00824</a> <a href="/module/M00825">M00825</a>]. The 10-membered enediyne such as calicheamicin also contains an allylic trisulfide group, which acts as a trigger for diradical formation. This diagram shows the biosynthesis of C-1027, maduropeptin, neocarzinostatin, kedarcidin and calicheamicin. Some aromatic moieties are synthesized via iterative type I polyketide synthases, and others are derived from chorismate and aromatic amino acids such as tyrosine and azatyrosine [MD:<a href="/module/M00829">M00829</a> <a href="/module/M00830">M00830</a> <a href="/module/M00831">M00831</a> <a href="/module/M00834">M00834</a> <a href="/module/M00826">M00826</a> <a href="/module/M00827">M00827</a> <a href="/module/M00828">M00828</a> <a href="/module/M00832">M00832</a>]. Finally, the aromatic and sugar building blocks are attached to the enediyne core by acyltransferases, condensation enzymes and glucosyltransferases [MD:<a href="/module/M00833">M00833</a>].<br> </div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td31 defd"><div class="cel">Metabolism; Metabolism of terpenoids and polyketides<br> </div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Pathway map</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/rn01059">rn01059</a>  </span></td><td>Biosynthesis of enediyne antibiotics</td></tr></table><center><a href="/pathway/rn01059"><img src="/kegg/misc/thumbnail/map01059.gif" alt="rn01059" style="border-style:none;"></a></center><br><button class="btn" onclick="location.href='https://www.kegg.jp/kegg-bin/view_ortholog_table?map=01059';return false;">Ortholog table</button></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Module</span></th> <td class="td31 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00824">M00824</a>  </span></td><td>9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core [PATH:<a href="/pathway/rn01059+M00824">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00825">M00825</a>  </span></td><td>10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core [PATH:<a href="/pathway/rn01059+M00825">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00826">M00826</a>  </span></td><td>C-1027 benzoxazolinate moiety biosynthesis, chorismate => benzoxazolinyl-CoA [PATH:<a href="/pathway/rn01059+M00826">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00827">M00827</a>  </span></td><td>C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP [PATH:<a href="/pathway/rn01059+M00827">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00828">M00828</a>  </span></td><td>Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP [PATH:<a href="/pathway/rn01059+M00828">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00829">M00829</a>  </span></td><td>3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA [PATH:<a href="/pathway/rn01059+M00829">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00830">M00830</a>  </span></td><td>Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA [PATH:<a href="/pathway/rn01059+M00830">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00831">M00831</a>  </span></td><td>Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA [PATH:<a href="/pathway/rn01059+M00831">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00832">M00832</a>  </span></td><td>Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP [PATH:<a href="/pathway/rn01059+M00832">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00833">M00833</a>  </span></td><td>Calicheamicin biosynthesis, calicheamicinone => calicheamicin [PATH:<a href="/pathway/rn01059+M00833">rn01059</a>]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/module/M00834">M00834</a>  </span></td><td>Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP [PATH:<a href="/pathway/rn01059+M00834">rn01059</a>]</td></tr></table></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reaction</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07253">R07253</a>  </span></td><td>acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08956">R08956</a>  </span></td><td>(2S)-2-amino-4-deoxychorismate:L-glutamate aminotransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R09559">R09559</a>  </span></td><td>(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R10731">R10731</a>  </span></td><td>(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein],FADH2:oxygen oxidoreductase (5-hydroxylating)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R10771">R10771</a>  </span></td><td>2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R10796">R10796</a>  </span></td><td>2-hydroxy-5-methyl-1-naphthoate,reduced ferredoxin:oxygen oxidoreductase (7-hydroxylating)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R10963">R10963</a>  </span></td><td>S-adenosyl-L-methionine:2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11125">R11125</a>  </span></td><td>malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid forming)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11362">R11362</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11363">R11363</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11364">R11364</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11365">R11365</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11366">R11366</a>  </span></td><td>L-tyrosine 2,3-aminomutase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11367">R11367</a>  </span></td><td>(S)-beta-tyrosine:[peptidyl-carrier protein] ligase (AMP-forming)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11368">R11368</a>  </span></td><td>(S)-beta-tyrosyl-[pcp]:FADH2 oxidoreductase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11369">R11369</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11370">R11370</a>  </span></td><td>6-methylsalicylate:CoA ligase (AMP-forming)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11371">R11371</a>  </span></td><td>S-adenosyl-L-methionine:6-methylsalicylyl-CoA 3-C-methyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11387">R11387</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11388">R11388</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11389">R11389</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11390">R11390</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11391">R11391</a>  </span></td><td>2-aza-L-tyrosine 2,3-aminomutase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11392">R11392</a>  </span></td><td>(R)-2-aza-beta-tyrosine:[peptidyl-carrier protein] ligase (AMP-forming)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11393">R11393</a>  </span></td><td>(R)-2-aza-beta-tyrosyl-[pcp]:FADH2 oxidoreductase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11412">R11412</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11413">R11413</a>  </span></td><td>S-adenosyl-L-methionine:orsellinate-[acp] O-methyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11414">R11414</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11415">R11415</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11416">R11416</a>  </span></td><td>S-adenosyl-L-methionine:3-hydroxy-5-iodo-2-methoxyorsellinate-[acp] O-methyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11417">R11417</a>  </span></td><td>dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose:calicheamicinone 4-hydroxyamino-4,6-dideoxy-alpha-D-glucosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11418">R11418</a>  </span></td><td>dTDP-4-deoxy-4-thio-alpha-D-digitoxose:calicheamicin-T0 4-deoxy-4-thio-alpha-D-digitoxosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11419">R11419</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11420">R11420</a>  </span></td><td>dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose:calicheamicin-PsAg 4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11421">R11421</a>  </span></td><td>dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose:calicheamicin-alpha3(I) 4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11422">R11422</a>  </span></td><td>dTDP-3'-O-methyl-beta-L-rhamnose:calicheamicin-alpha1(I) 3'-O-methyl-beta-L-rhamnosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11423">R11423</a>  </span></td><td>dTDP-3'-O-methyl-beta-L-rhamnose:calicheamicin-PsAg 3'-O-methyl-beta-L-rhamnosyltransferase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11429">R11429</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11430">R11430</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11431">R11431</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11432">R11432</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11433">R11433</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11434">R11434</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11435">R11435</a>  </span></td><td> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R11436">R11436</a>  </span></td><td> </td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Compound</span></th> <td class="td31 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00082">C00082</a>  </span></td><td>L-Tyrosine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00083">C00083</a>  </span></td><td>Malonyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00251">C00251</a>  </span></td><td>Chorismate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00636">C00636</a>  </span></td><td>D-Mannose 1-phosphate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C02657">C02657</a>  </span></td><td>6-Methylsalicylate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11438">C11438</a>  </span></td><td>C-1027 Chromophore</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11442">C11442</a>  </span></td><td>Aromatized C-1027 chromophore</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11447">C11447</a>  </span></td><td>dTDP-4-dimethylamino-4,6-dideoxy-5-C-methyl-D-allose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11448">C11448</a>  </span></td><td>3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carbonyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11449">C11449</a>  </span></td><td>(S)-3-Chloro-4,5-dihydroxy-beta-phenylalanyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11468">C11468</a>  </span></td><td>3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic acid</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C11469">C11469</a>  </span></td><td>Calicheamicin gamma(1)I</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C12049">C12049</a>  </span></td><td>Neocarzinostatin chromophore</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C18054">C18054</a>  </span></td><td>2-Amino-2-deoxyisochorismate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C19686">C19686</a>  </span></td><td>3-(1-Carboxyvinyloxy)anthranilate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C20810">C20810</a>  </span></td><td>(S)-3-Chloro-beta-tyrosyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C20841">C20841</a>  </span></td><td>2-Hydroxy-7-methoxy-5-methyl-1-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C20842">C20842</a>  </span></td><td>2-Hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C20856">C20856</a>  </span></td><td>2-Hydroxy-5-methyl-1-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C20857">C20857</a>  </span></td><td>2,7-Dihydroxy-5-methyl-1-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21292">C21292</a>  </span></td><td>Maduropeptin chromophore</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21301">C21301</a>  </span></td><td>Kedarcidin chromophore</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21306">C21306</a>  </span></td><td>3,4-Dihydro-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21307">C21307</a>  </span></td><td>3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21308">C21308</a>  </span></td><td>(S)-beta-Tyrosine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21309">C21309</a>  </span></td><td>(S)-beta-Tyrosyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21311">C21311</a>  </span></td><td>3-(4-Hydroxyphenyl)-3-oxopropanoyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21312">C21312</a>  </span></td><td>6-Methylsalicylyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21313">C21313</a>  </span></td><td>3,6-Dimethylsalicylyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21314">C21314</a>  </span></td><td>NDP-D-mannose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21315">C21315</a>  </span></td><td>NDP-4-oxo-6-deoxy-D-mannose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21316">C21316</a>  </span></td><td>NDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21317">C21317</a>  </span></td><td>NDP-2-amino-4-oxo-2,6-dideoxy-D-galactose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21318">C21318</a>  </span></td><td>NDP-2-amino-2,6-dideoxy-D-galactose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21319">C21319</a>  </span></td><td>NDP-2-methylamino-2,6-dideoxy-D-galactose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21320">C21320</a>  </span></td><td>3,6,8-Trihydroxy-2-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21321">C21321</a>  </span></td><td>3,6,7,8-Tetrahydroxy-2-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21322">C21322</a>  </span></td><td>3-Hydroxy-6,7,8-trimethoxy-2-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21323">C21323</a>  </span></td><td>3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21324">C21324</a>  </span></td><td>3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21325">C21325</a>  </span></td><td>Azatyrosine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21326">C21326</a>  </span></td><td>(R)-2-Aza-beta-tyrosine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21327">C21327</a>  </span></td><td>(R)-2-Aza-beta-tyrosyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21328">C21328</a>  </span></td><td>(R)-2-Aza-3-chloro-beta-tyrosyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21337">C21337</a>  </span></td><td>Calicheamicinone</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21338">C21338</a>  </span></td><td>Calicheamicin T0</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21339">C21339</a>  </span></td><td>4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21340">C21340</a>  </span></td><td>Calicheamicin PsAg</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21341">C21341</a>  </span></td><td>Calicheamicin alpha1(I)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21342">C21342</a>  </span></td><td>Calicheamicin alpha3(I)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21343">C21343</a>  </span></td><td>Orsellinate-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21344">C21344</a>  </span></td><td>2-Methoxyorsellinate-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21345">C21345</a>  </span></td><td>5-Iodo-2-methoxyorsellinate-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21346">C21346</a>  </span></td><td>3-Hydroxy-5-iodo-2-methoxyorsellinate-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21347">C21347</a>  </span></td><td>5-Iodo-2,3-dimethoxyorsellinate-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21348">C21348</a>  </span></td><td>dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21349">C21349</a>  </span></td><td>dTDP-4-deoxy-4-thio-alpha-D-digitoxose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21350">C21350</a>  </span></td><td>dTDP-3-O-methyl-beta-L-rhamnose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21356">C21356</a>  </span></td><td>dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21357">C21357</a>  </span></td><td>3-Hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-[acp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21358">C21358</a>  </span></td><td>1,3,5,7,9,11,13-Pentadecaheptaene</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21361">C21361</a>  </span></td><td>3-(2-Chloro-3-hydroxy-4-methoxyphenyl)-3-hydroxypropanoyl-[pcp]</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C21363">C21363</a>  </span></td><td>dTDP-madurosamine</td></tr></table></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20336235">20336235</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Liang ZX</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Complexity and simplicity in the biosynthesis of enediyne natural products.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Nat Prod Rep 27:499-528 (2010)<br>DOI:<a href="https://doi.org/10.1039/b908165h">10.1039/b908165h</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18397168">18397168</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Biosynthesis of enediyne antitumor antibiotics.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Curr Top Med Chem 8:448-59 (2008)<br>DOI:<a href="https://doi.org/10.2174/156802608783955656">10.2174/156802608783955656</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/12183628">12183628</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Liu W, Christenson SD, Standage S, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Biosynthesis of the enediyne antitumor antibiotic C-1027.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Science 297:1170-3 (2002)<br>DOI:<a href="https://doi.org/10.1126/science.1072110">10.1126/science.1072110</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/12183629">12183629</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">The calicheamicin gene cluster and its iterative type I enediyne PKS.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Science 297:1173-6 (2002)<br>DOI:<a href="https://doi.org/10.1126/science.1072105">10.1126/science.1072105</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/17918933">17918933</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 129:13082-94 (2007)<br>DOI:<a href="https://doi.org/10.1021/ja073275o">10.1021/ja073275o</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/15797213">15797213</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Chem Biol 12:293-302 (2005)<br>DOI:<a href="https://doi.org/10.1016/j.chembiol.2004.12.013">10.1016/j.chembiol.2004.12.013</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23360970">23360970</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Mol Biosyst 9:478-91 (2013)<br>DOI:<a href="https://doi.org/10.1039/c3mb25523a">10.1039/c3mb25523a</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/19362637">19362637</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Horsman GP, Van Lanen SG, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Iterative type I polyketide synthases for enediyne core biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Methods Enzymol 459:97-112 (2009)<br>DOI:<a href="https://doi.org/10.1016/S0076-6879(09)04605-9">10.1016/S0076-6879(09)04605-9</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20024241">20024241</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Sun H, Kong R, Zhu D, Lu M, Ji Q, Liew CW, Lescar J, Zhong G, Liang ZX</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Chem Commun (Camb) 7399-401 (2009)<br>DOI:<a href="https://doi.org/10.1039/b916751j">10.1039/b916751j</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18223152">18223152</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Proc Natl Acad Sci U S A 105:1460-5 (2008)<br>DOI:<a href="https://doi.org/10.1073/pnas.0711625105">10.1073/pnas.0711625105</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/19689130">19689130</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Belecki K, Crawford JM, Townsend CA</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 131:12564-6 (2009)<br>DOI:<a href="https://doi.org/10.1021/ja904391r">10.1021/ja904391r</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/19357082">19357082</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Kotaka M, Kong R, Qureshi I, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Biol Chem 284:15739-49 (2009)<br>DOI:<a href="https://doi.org/10.1074/jbc.M809669200">10.1074/jbc.M809669200</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/24041368">24041368</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Belecki K, Townsend CA</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 135:14339-48 (2013)<br>DOI:<a href="https://doi.org/10.1021/ja406697t">10.1021/ja406697t</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20534556">20534556</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Horsman GP, Chen Y, Thorson JS, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Proc Natl Acad Sci U S A 107:11331-5 (2010)<br>DOI:<a href="https://doi.org/10.1073/pnas.1003442107">10.1073/pnas.1003442107</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/25278375">25278375</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Chen X, Ji R, Jiang X, Yang R, Liu F, Xin Y</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Iterative type I polyketide synthases involved in enediyne natural product biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">IUBMB Life 66:587-95 (2014)<br>DOI:<a href="https://doi.org/10.1002/iub.1316">10.1002/iub.1316</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/19856960">19856960</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Lin S, Horsman GP, Chen Y, Li W, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 131:16410-7 (2009)<br>DOI:<a href="https://doi.org/10.1021/ja901242s">10.1021/ja901242s</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23844627">23844627</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Biochemistry 52:5217-24 (2013)<br>DOI:<a href="https://doi.org/10.1021/bi400572a">10.1021/bi400572a</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20704329">20704329</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Lin S, Horsman GP, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Org Lett 12:3816-9 (2010)<br>DOI:<a href="https://doi.org/10.1021/ol101473t">10.1021/ol101473t</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18182490">18182490</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Lin S, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Proc Natl Acad Sci U S A 105:494-9 (2008)<br>DOI:<a href="https://doi.org/10.1073/pnas.0708750105">10.1073/pnas.0708750105</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/14580219">14580219</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Christenson SD, Wu W, Spies MA, Shen B, Toney MD</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Biochemistry 42:12708-18 (2003)<br>DOI:<a href="https://doi.org/10.1021/bi035223r">10.1021/bi035223r</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16887797">16887797</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Biol Chem 281:29633-40 (2006)<br>DOI:<a href="https://doi.org/10.1074/jbc.M605887200">10.1074/jbc.M605887200</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16104723">16104723</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 127:11594-5 (2005)<br>DOI:<a href="https://doi.org/10.1021/ja052871k">10.1021/ja052871k</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18426211">18426211</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Lin S, Van Lanen SG, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 130:6616-23 (2008)<br>DOI:<a href="https://doi.org/10.1021/ja710601d">10.1021/ja710601d</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/19817865">19817865</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Van Lanen SG, Lin S, Horsman GP, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">FEMS Microbiol Lett 300:237-41 (2009)<br>DOI:<a href="https://doi.org/10.1111/j.1574-6968.2009.01802.x">10.1111/j.1574-6968.2009.01802.x</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23034235">23034235</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Lohman JR, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Methods Enzymol 516:299-319 (2012)<br>DOI:<a href="https://doi.org/10.1016/B978-0-12-394291-3.00007-1">10.1016/B978-0-12-394291-3.00007-1</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20718468">20718468</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">J Am Chem Soc 132:12534-6 (2010)<br>DOI:<a href="https://doi.org/10.1021/ja1050814">10.1021/ja1050814</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23633564">23633564</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Huang SX, Lohman JR, Huang T, Shen B</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Proc Natl Acad Sci U S A 110:8069-74 (2013)<br>DOI:<a href="https://doi.org/10.1073/pnas.1304733110">10.1073/pnas.1304733110</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18561189">18561189</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">McCoy JG, Johnson HD, Singh S, Bingman CA, Lei IK, Thorson JS, Phillips GN Jr</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Proteins 74:50-60 (2009)<br>DOI:<a href="https://doi.org/10.1002/prot.22131">10.1002/prot.22131</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/24978950">24978950</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Singh S, Nandurkar NS, Thorson JS</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Chembiochem 15:1418-21 (2014)<br>DOI:<a href="https://doi.org/10.1002/cbic.201402119">10.1002/cbic.201402119</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/21358050">21358050</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td31 repd"><div class="cel">Chang A, Singh S, Bingman CA, Thorson JS, Phillips GN Jr</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td30 repd"><div class="cel">Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td31 repd"><div class="cel">Acta Crystallogr D Biol Crystallogr 67:197-203 (2011)<br>DOI:<a href="https://doi.org/10.1107/S090744491100360X">10.1107/S090744491100360X</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Related<br>pathway</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/rn00400">rn00400</a>  </span></td><td>Phenylalanine, tyrosine and tryptophan biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/rn00523">rn00523</a>  </span></td><td>Polyketide sugar unit biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/rn00620">rn00620</a>  </span></td><td>Pyruvate metabolism</td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">KO pathway</span></th> <td class="td31 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/ko01059">ko01059</a>  </span></td><td> </td></tr></table></td></tr> <tr><th class="th30 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td30 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?pathway+rn01059';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>