CINXE.COM

<!DOCTYPE html> <html lang="en"> <head id="Head1"><meta name="viewport" content="width=device-width, initial-scale=1.0" /><meta http-equiv="X-UA-Compatible" content="IE=edge" /><title> Crisis in Clinical Research - Society for Immunotherapy of Cancer (SITC) </title><meta name='audience' content='ALL' /><meta name='rating' content='General' /><meta name='distribution' content='Global, Worldwide' /><meta name='copyright' content='Higher Logic, LLC' /><meta name='content-language' content='EN' /><meta name='referrer' content='strict-origin-when-cross-origin' /><link rel="apple-touch-icon" href="//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/sitc_log_color_250px.png" /><meta name="apple-itunes-app" content="app-id=1555408470, app-argument=http://www.sitcancer.org/advocacy/crisis-in-clinical-research"><link rel='SHORTCUT ICON' href='https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC%20CONNECT%20favicon.ico' type='image/ico' /><link href='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/Font-Awesome/6.4.2-pro/css/all.min.css' type='text/css' rel='stylesheet' /><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/themes/prism.min.css" integrity="sha512-tN7Ec6zAFaVSG3TpNAKtk4DOHNpSwKHxxrsiw4GHKESGPs5njn/0sMCUMl2svV4wo4BK/rCP7juYz+zx+l6oeQ==" crossorigin="anonymous" referrerpolicy="no-referrer" /><link href='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/css/bootstrap.min.css' rel='stylesheet' /><link type='text/css' rel='stylesheet' href='https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.d7804150d2a3d23b0f7bd53234959d21d94a14f1.hash.css'/><link href='https://ajax.googleapis.com/ajax/libs/jqueryui/1.10.1/themes/base/jquery-ui.css' type='text/css' rel='stylesheet' /><link href='https://d132x6oi8ychic.cloudfront.net/higherlogic/microsite/generatecss/2b495af7-ef43-40d3-8f8d-d42fc2073d1a/939633a7-7477-45a6-b147-239f9fccc7b2/638682255337900000/34' type='text/css' rel='stylesheet' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/npm/instantsearch.css@8.0.0/themes/satellite-min.css' /><link type='text/css' rel='stylesheet' href='https://maxcdn.bootstrapcdn.com/font-awesome/4.5.0/css/font-awesome.min.css' /><link type='text/css' rel='stylesheet' href='https://fonts.googleapis.com/css?family=Dosis:500,700' /><link type='text/css' rel='stylesheet' href='https://fonts.googleapis.com/css?family=Open+Sans:400,700' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.css' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick-theme.css' /><link type='text/css' rel='stylesheet' href='https://use.typekit.net/cqp4ikw.css' /><link type='text/css' rel='stylesheet' href='https://use.typekit.net/zyl7cfs.css' /><link rel="stylesheet" type="text/css" href="https://d2x5ku95bkycr3.cloudfront.net/App_Themes/Common/PhoneLogo.css" /><script type='text/javascript' src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/promise-fetch-polyfill.js'></script><script type='text/javascript' src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/systemjs/3.1.6/system.min.js'></script><script type='systemjs-importmap' src='/HigherLogic/JavaScript/importmapping-cdn.json?638682928522347045'></script><script type='text/javascript' src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlq-2024-05-08.js'></script><script src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlqmigrate-2024-05-08.js'></script><script type='text/javascript' src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlqui-2024-05-08.js'></script><script src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/js/bootstrap.min.js'></script><script type='text/javascript'>var higherlogic_crestApi_origin = 'https://api.connectedcommunity.org'</script><script type='text/javascript' src='/HigherLogic/CORS/easyXDM/easyXDM.Min.js'></script><script src="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/prism.min.js" integrity="sha512-axJX7DJduStuBB8ePC8ryGzacZPr3rdLaIDZitiEgWWk2gsXxEFlm4UW0iNzj2h3wp5mOylgHAzBzM4nRSvTZA==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/plugins/autoloader/prism-autoloader.min.js" integrity="sha512-xCfKr8zIONbip3Q1XG/u5x40hoJ0/DtP1bxyMEi0GWzUFoUffE+Dfw1Br8j55RRt9qG7bGKsh+4tSb1CvFHPSA==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><script type='text/javascript' src='https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.a15963cc8802bf5ef87ffb22f53b2f3528e2cc6f.hash.js'></script><script type='text/javascript' src='https://cdnjs.cloudflare.com/ajax/libs/html2pdf.js/0.9.2/html2pdf.bundle.min.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/npm/instantsearch.js@4.56.11/dist/instantsearch.production.min.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/npm/algoliasearch@4.20.0/dist/algoliasearch-lite.umd.js'></script><script type='text/javascript' src='https://use.typekit.net/fho7nrh.js'></script><script type='text/javascript' src='https://use.fortawesome.com/7f3536d6.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.min.js'></script><script type='text/javascript' src='https://cdnjs.cloudflare.com/ajax/libs/jspdf/1.3.2/jspdf.debug.js'></script><script type='text/javascript' src='https://unpkg.com/jspdf-autotable'></script><script type='text/javascript' src='https://use.fortawesome.com/39cff8dc.js'></script><meta property="og:title" content="Crisis in Clinical Research"><script>window.CDN_PATH = 'https://d3uf7shreuzboy.cloudfront.net'</script><script>var filestackUrl = 'https://static.filestackapi.com/filestack-js/3.28.0/filestack.min.js'; var filestackUrlIE11 = 'https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/filestack.ie11.min.js';</script><script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-M6VQVS2');</script><style type="text/css"> /* <![CDATA[ */ #AuxMenu img.icon { border-style:none;vertical-align:middle; } #AuxMenu img.separator { border-style:none;display:block; } #AuxMenu img.horizontal-separator { border-style:none;vertical-align:middle; } #AuxMenu ul { list-style:none;margin:0;padding:0;width:auto; } #AuxMenu ul.dynamic { z-index:1; } #AuxMenu a { text-decoration:none;white-space:nowrap;display:block; } #AuxMenu a.static { text-decoration:none;border-style:none;padding-left:0.15em;padding-right:0.15em; } #AuxMenu a.popout { background-image:url("/WebResource.axd?d=YAYach_zykzn7tRotFpEUpLbm8-AaEF0ex9x_GTRQp7fxYLqbSBT-ykmKxq6l97s05rGQ3KpCAtPii7g5ccpXmGPv1HPy_UocdN-ygwKcio1&t=638628063619783110");background-repeat:no-repeat;background-position:right center;padding-right:14px; } /* ]]> */ </style><meta name="description" content="The Society for Immunotherapy of Cancer (SITC) is convening key oncology experts from academia, industry and government, including the FDA and NCI, to lead a national conversation around what’s become a crisis in clinical research." /></head> <body class="bodyBackground crisis interior "> <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-M6VQVS2" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div id="MPOuterMost" class="container full"> <form method="post" action="./crisis-in-clinical-research" onsubmit="javascript:return WebForm_OnSubmit();" id="MasterPageForm" class="form"> <div class="aspNetHidden"> <input type="hidden" name="ScriptManager1_TSM" id="ScriptManager1_TSM" value="" /> <input type="hidden" name="StyleSheetManager1_TSSM" id="StyleSheetManager1_TSSM" value="" /> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['MasterPageForm']; if (!theForm) { theForm = document.MasterPageForm; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/WebForms.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ window.WebForm_PostBackOptions||document.write('<script type="text/javascript" src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDy7_GOIpjJ0Ev_gCdQYqqHk_ZWFLV5XISDcYendLTMgPoYek08VT5y3fOFST6xT6Q2&t=638628063619783110"><\/script>');//]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MenuStandards.js" type="text/javascript"></script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MicrosoftAjax.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ (window.Sys && Sys._Application && Sys.Observer)||document.write('<script type="text/javascript" src="/ScriptResource.axd?d=uHIkleVeDJf4xS50Krz-yKqyI6ItVec4s3idbjHVhZG9J4GiEigPlJ1Pr7dbHMCyIOf7kxfX3Nb7yVtUXhwQ7AOu-iPRjdC_l5vxB_gc6Z3Dxd5tRPLJv-GNFNwaN0H-W3X3hfs6Qrai_oPPvnAUre8zbJUdf1a1YJ0rNRsMv-o1&t=2a9d95e3"><\/script>');//]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MicrosoftAjaxWebForms.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ (window.Sys && Sys.WebForms)||document.write('<script type="text/javascript" src="/ScriptResource.axd?d=Jw6tUGWnA15YEa3ai3FadCxOzjXo7DUqjVdZ-ppUm_hmRsjByokg8vJsbXd_vty5sSD7cLjWah6CFay_-VEpx11xzWP5I0beGdwJH7ICkEzqKBZp0aF_WH7BGPayHXieN2_FVY_LynI6wS_6mDtAk2iKQomHaPnn3KkQQDR1LTw1&t=2a9d95e3"><\/script>');function WebForm_OnSubmit() { null; return true; } //]]> </script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="738F2F5A" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="CfDJ8GYwqx9YzLZGmPQ2hZZF70KFINHGYoOE974JtGq/OfOCD+SXu+aUn16U1COZNN0d7CZfP1iWLlzHwYvstiNH8GseUCVlxFKZIo4xA7d7tigrMfW5ElzfHg39F3kkBsL7xJH/6Z5rgsxoABXq/u7Ewu0VF06HKcR2ymiY2G9469ymAVSy7KExO9pZe6T1+r13XmcRaDOXPFH9ItngLg4oKCo=" /> </div> <input name="__HL-RequestVerificationToken" type="hidden" value="CfDJ8GYwqx9YzLZGmPQ2hZZF70I4At_ap2F01raw9ww6rMKOxIyyr6Pmv4C-McwnqcaOiWXbr9GCib3dkqADfHt5wsN3C4c6SB4w_S4HKeBWB--ipQR1slAPm2JKgkHVWbV0gRFd3Wf-Z1ABHDVOoBMZwrw1" /> <div id="pnlCookieNotification" class="row cookie-notification-bar banner-bottom"> <div class="col-md-10 message-container"> <span id="lblCnMessage">This website uses cookies to deliver to you the best experience possible on SITC CONNECT. By continuing to use this site, you are providing to us your consent to ensure you receive such an experience.</span>  <a id="hypCnLearnMore" href="http://www.sitcancer.org/aboutsitc/privacy-policy" target="CookieNotification">View our privacy policy to learn more.</a> </div> <div class="col-md-2"> <div class="pull-right"> <button type="button" class="btn btn-success" data-microsite-key="2c19e5a6-3adb-4d01-b46c-c01e11745b3a" onclick="HigherLogic.Microsites.Ui.dropCookieNotification(this);"> <span class="glyphicon glyphicon-ok"></span> OK </button> </div> </div> </div> <div id="GlobalMain"> <script type="text/javascript"> //<![CDATA[ Sys.WebForms.PageRequestManager._initialize('ctl00$ScriptManager1', 'MasterPageForm', [], [], [], 90, 'ctl00'); //]]> </script> </div> <div id="GlobalMessageContainer"> <div id="GlobalMessageContent" > <img ID="GlobalMsg_Img" alt="Message Image" src=""/>   <span id="GlobalMsg_Text"></span><br /><br /> </div> </div> <div id="react-setup" style="height:0"> <script> var formTokenElement = document.getElementsByName('__HL-RequestVerificationToken')[0]; var formToken = formTokenElement? formTokenElement.value : ''; window.fetchOCApi = function(url, params) { return fetch(url, { method: 'POST', body: JSON.stringify(params), headers: { RequestVerificationFormToken: formToken, 'Content-Type': 'application/json' } }).then(function(response) { return response.json(); }).then(function(body) { return body.data }); } </script> <div id="__hl-activity-trace" traceId="37a976a023b62baa56c5846b5391f473" spanId="2881d61e29b70298" tenantCode="SITCANCER" micrositeKey="2c19e5a6-3adb-4d01-b46c-c01e11745b3a" navigationKey="39158ae9-34ac-4f26-877f-2463f2d7b8a4" navigationName="crisis-in-clinical-research" viewedByContactKey="00000000-0000-0000-0000-000000000000" pageOrigin="http://www.sitcancer.org" pagePath="/advocacy/crisis-in-clinical-research" referrerUrl="" userHostAddress="8.222.208.146 " userAgent="Mozilla/4.0 (compatible; MSIE 7.0; Windows NT 6.0; SLCC1; .NET CLR 2.0.50727; .NET CLR 3.0.04506; .NET CLR 3.5.21022; .NET CLR 1.0.3705; .NET CLR 1.1.4322)" ></div> <div id="page-react-root"></div> <script id="hlReactRootLegacyRemote" defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRootLegacy/ReactRootLegacy~hlReactRootLegacyRemote.bundle.e3e14a157800b68e8ff0.hash.js"></script> <script>window.reactroot_webpackPublicPath = 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/'</script> <script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~runtime~main.bundle.e7f477778cba7f022a3d.hash.js"></script> <script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~react-_yarn_cache_react-npm-18_2_0-1eae08fee2-b9214a9bd7_zip_node_modules_react_index_js.bundle.012593f3ef708f027ac2.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn___virtual___react-dom-virtual-05f150c4a1_0_cache_react-dom-npm-18_2_0-dd675bca1c-65c11b.bundle.8b02460446e4027ef67f.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn___virtual___react-dom-virtual-05f150c4a1_0_cache_react-dom-npm-18_2_0-dd675bca1c-17e4a5.bundle.1dbb26f4013744b692d1.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn_cache_lodash-npm-4_17_21-6382451519-c08619c038_zip_node_modules_lodash_lodash_js.bundle.8d689d0e26f432a3f17d.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~main.bundle.d9c6907ad1d4db1ca2e8.hash.js"></script> <script> window.hl_tinyMceIncludePaths = { cssIncludes: 'https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/Font-Awesome/6.4.2-pro/css/all.min.css|https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/themes/prism.min.css|https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/css/bootstrap.min.css|https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.d7804150d2a3d23b0f7bd53234959d21d94a14f1.hash.css|https://ajax.googleapis.com/ajax/libs/jqueryui/1.10.1/themes/base/jquery-ui.css|https://d132x6oi8ychic.cloudfront.net/higherlogic/microsite/generatecss/2b495af7-ef43-40d3-8f8d-d42fc2073d1a/939633a7-7477-45a6-b147-239f9fccc7b2/638682255337900000/34|https://cdn.jsdelivr.net/npm/instantsearch.css@8.0.0/themes/satellite-min.css|https://maxcdn.bootstrapcdn.com/font-awesome/4.5.0/css/font-awesome.min.css|https://fonts.googleapis.com/css?family=Dosis:500,700|https://fonts.googleapis.com/css?family=Open+Sans:400,700|https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.css|https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick-theme.css|https://use.typekit.net/cqp4ikw.css|https://use.typekit.net/zyl7cfs.css', tinymcejs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce.bc594acd1c86ca782a5f0446e0276d20202ffaf9.hash.js', hashmentionjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_hashmention.94b265db0d98038d20e17308f50c5d23682bf370.hash.js', mentionjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_mention.a35f893e40ce48b298979135724cd9e6ad18dde1.hash.js', hashtagjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_hashtag.5579d26160cf6c00ace1fde0afcb2aacaf5baceb.hash.js' }; </script> <script> window.addEventListener('DOMContentLoaded', function (){ window.renderReactRoot( [], 'page-react-root', {"tenant":{"name":"Society for Immunotherapy of Cancer","logoPath":"https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-pms-horz_430px.png","contactSummary":"<address> 555 East Wells Street, Suite 1100<br />Milwaukee WI 53202-3823<br />United States<br />Phone: +1 414-271-2456<br /></address>"},"communityKey":"00000000-0000-0000-0000-000000000000","micrositeKey":"2c19e5a6-3adb-4d01-b46c-c01e11745b3a","canUserEditPage":false,"isUserAuthenticated":false,"isUserSuperAdmin":false,"isUserCommunityAdmin":false,"isUserSiteAdmin":false,"isUserCommunityModerator":false,"currentUserContactKey":"00000000-0000-0000-0000-000000000000","isTopicCommunity":false,"isSelfModerationCommunity":false,"loginUrl":"https://sitc.execinc.com/HigherLogic/HLLoginRedirect.aspx?Redirect=","colorPickerDefaults":{"primaryColor":null,"textOnPrimary":null,"secondaryColor":null,"textOnSecondary":null,"linkColor":null,"linkHoverColor":null,"footerBackgroundColor":null,"footerTextColor":null}} ) }); </script> <svg aria-hidden="true" style="height: 0px;"> <defs> <linearGradient id="skeleton-svg-gradient" x1="0" x2="1" y1="0" y2="1"> <stop offset="0%" stop-color="rgba(239, 239, 239, 0.25)"> <animate attributeName="stop-color" values="rgba(239, 239, 239, 0.25); rgba(68, 72, 85, 0.2); rgba(239, 239, 239, 0.25);" dur="3s" repeatCount="indefinite"></animate> </stop> <stop offset="100%" stop-color="rgba(68, 72, 85, 0.2)"> <animate attributeName="stop-color" values="rgba(68, 72, 85, 0.2); rgba(239, 239, 239, 0.25); rgba(68, 72, 85, 0.2);" dur="3s" repeatCount="indefinite"></animate> </stop> </linearGradient> </defs> </svg> </div> <div id="MPOuterHeader" class="row siteFrame"> <div class="col-md-12"> <div id="HEADER" class="row"> <div class="col-md-12"> <div class="ContentUserControl search-field-wrapper"> <script type="text/javascript"> System.import('Common/SearchBox.js').then(function () { $('#AddlContentHeaderTop_ctl01_SearchButton').click(function () { $('#AddlContentHeaderTop_ctl01_hiddenSearchButton').click(); }); $('#AddlContentHeaderTop_ctl01_SearchOptions').click(function (e) { e.stopPropagation(); }); if ('False' == 'True') { $('#AddlContentHeaderTop_ctl01_SearchTerm').click(function (e) { $('#AddlContentHeaderTop_ctl01_SearchBoxToggle').addClass('open'); e.stopPropagation(); }); $('#AddlContentHeaderTop_ctl01_SearchTerm').focus(function (e) { $('#AddlContentHeaderTop_ctl01_SearchBoxToggle').addClass('open'); e.stopPropagation(); }); $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_StartDate').hide(); $('#AddlContentHeaderTop_ctl01_SearchTerm').focus(function () { $('#AddlContentHeaderTop_ctl01_SearchOptions').show(); }); $('#AddlContentHeaderTop_ctl01_DateRangeDDL').change(function () { if ($('#AddlContentHeaderTop_ctl01_DateRangeDDL').find(":selected").text() == 'on this day') { $('#AddlContentHeaderTop_ctl01_StartDate').show(); $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_EndDate').val(""); } else if ($('#AddlContentHeaderTop_ctl01_DateRangeDDL').find(":selected").text() == 'All') { $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_StartDate').hide(); } else { $('#AddlContentHeaderTop_ctl01_StartDate').show(); $('#AddlContentHeaderTop_ctl01_EndDate').show(); } }); } $('#AddlContentHeaderTop_ctl01_SearchInputs') .hl_ui_common_searchBox({ controlId: 'AddlContentHeaderTop_ctl01_SearchInputs', inputId: 'AddlContentHeaderTop_ctl01_SearchTerm', buttonId: 'AddlContentHeaderTop_ctl01_hiddenSearchButton' }); }); </script> <button id="SearchToggleIcon" type="button" class="btn btn-default" style="display: none;" role="button" aria-label="searchToggle"> <span class="glyphicon glyphicon-search" style="vertical-align: middle"></span> </button> <div id="AddlContentHeaderTop_ctl01_newSearchBox"> <div id="AddlContentHeaderTop_ctl01_SearchInputs" class="SearchInputs"> <div id="AddlContentHeaderTop_ctl01_WholeSearch" onkeypress="javascript:return WebForm_FireDefaultButton(event, 'AddlContentHeaderTop_ctl01_hiddenSearchButton')"> <div class="input-group" style="vertical-align: middle"> <input name="ctl00$AddlContentHeaderTop$ctl01$SearchTerm" type="text" id="AddlContentHeaderTop_ctl01_SearchTerm" class="form-control" autocomplete="off" qa-id="search-term" aria-label="search box" placeholder="search" Title="search" style="font-weight: normal;" /> <div id="AddlContentHeaderTop_ctl01_SearchBoxToggle" class="input-group-btn search-box-toggle"> <button id="AddlContentHeaderTop_ctl01_OptionsButton" type="button" style="display: none;" class="btn btn-default dropdown-toggle" data-toggle="dropdown" aria-label="search options"> <span class="caret"></span> <span class="sr-only">Search Options</span> </button> <button id="AddlContentHeaderTop_ctl01_SearchButton" type="button" class="btn btn-default " role="button" aria-label="search"> <span class="glyphicon glyphicon-search" style="vertical-align: middle"></span> </button> <ul class="dropdown-menu pull-right" role="menu"> <li> </li> </ul> </div> <input type="submit" name="ctl00$AddlContentHeaderTop$ctl01$hiddenSearchButton" value="" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$AddlContentHeaderTop$ctl01$hiddenSearchButton", "", true, "", "", false, false))" id="AddlContentHeaderTop_ctl01_hiddenSearchButton" style="display: none;" /> </div> </div> </div> </div> </div><div class="ContentItemHtml join-renew"> <div class="HtmlContent"><ul> <li><a href="https://sitc.execinc.com/edibo/Signup?_ga=2.186844974.764178562.1672778726-1617584964.1657890282" target="_blank" rel="noopener">Join SITC</a></li> <li><a href="https://www.sitcancer.org/membership/renew" target="_blank" rel="noopener">Renew</a></li> </ul></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml make-a-gift"> <div class="HtmlContent"><a href="https://sitc.sitcancer.org/donate/?_ga=2.4473523.1866415943.1648138048-1544668743.1643294471">Make a Gift</a></div><div class="HtmlFooter"></div></div><div class="ContentUserControl"> <script charset="utf-8">function handleStickyHeader() { var headerHeight = $('#MPOuterHeader').outerHeight(); // handle mobile navigation being present if ($(window).width() > 767) { $("#MPContentArea").css('padding-top', headerHeight + 'px'); } else { $("#MPContentArea").css('padding-top', '0'); } } $(function () { handleStickyHeader(); $(window).resize(function () { handleStickyHeader(); }); setTimeout(function () { handleStickyHeader(); }, 250); var headerHeight = $(MPOuterHeader).height(); $('a').on('click', function (event) { if ($(this).is('a[href^="#"]')) { event.preventDefault(); var hash = this.hash; $('html, body').animate({ scrollTop: $(hash).offset().top - 0 }, 500, function () { window.location.hash = headerHeight; } ); } }); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$('body').css('visibility', 'hidden'); $(document).ready(function() { $('body').css('visibility', 'visible').hide().fadeIn('slow'); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function() { $(".accordion-heading").each(function() { $(this).next(".accordion-text").andSelf().wrapAll("<div class='accordion-wrap' />"); }); $('.accordion-heading').on('click', function() { var items = []; $('.accordion-wrap').each(function (i, item) { items.push(item); }); $parent_box = $(this).closest('.accordion-wrap'); $parent_box.find('.accordion-text').slideToggle(600, 'swing'); $parent_box.toggleClass('open'); }); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function() { if (window.location.href.indexOf('#tab') > -1) { var url = window.location.href; str = url.split('#').pop(); // console.log(str[str.length - 1]); tabNum = '.tab-content.page-' + str[str.length - 1]; console.log(tabNum); $('.tab-content').hide(); $(tabNum).show(); } else { $('.tab-content').hide(); $('.tab-content.page-1').show(); } $('.tab-content').wrapAll('<div class="tab-content-wrap"></div>'); $('.tab-links li').click(function() { var elem = $(this).context, link = $(elem).find('a'), elementId = link.attr('id'); $('.tab-links li').removeClass('active'); $(this).addClass('active'); showTabContent(elementId); }); $('.tab-links ul li:first-child').addClass('active') }); function showTabContent(tabClass) { $('.tab-content').each(function() { var self = $(this), classes = self.attr('class'); if (classes.indexOf(tabClass) >= 0 || tabClass === 'all') { self.show(); } else { self.hide(); } }); }</script> </div><div class="ContentUserControl"> <script charset="utf-8">var popupCookies = [], link, href, target; $(function () { popup = $(".popup"); if (popup.length > 0) { handlePopup(); } }); function getCookies(cname) { popupCookies = []; var name = cname; var decodedCookie = decodeURIComponent(document.cookie); var ca = decodedCookie.split(";"); for (var i = 0; i < ca.length; i++) { var c = ca[i]; while (c.charAt(0) == " ") { c = c.substring(1); } if (c.indexOf(name) == 0) { popupCookies.push(c); } } // return ""; } function handlePopup() { getCookies("popup"); var popups = $("#HEADER .popup").toArray(); for (var i = 0; i < popupCookies.length; i++) { var text = popupCookies[i].substring(popupCookies[i].indexOf("=") + 2, 50); for (var j = 0; j < popups.length; j++) { if ($(popups[j]).text().indexOf(text) >= 0) { $(popups[j]).hide(); } else { $(popups[j]).append( '<button type="button" onclick="closePopup(this);"><i class="fal fa-times"></i></button>' ); } } } if (!popupCookies.length) { $("#HEADER .popup .HtmlContent").append( // '<button type="button" onclick="closePopup(this);"><i class="fal fa-times"></i></button>' '<button type="button" onclick="closePopup(this);" class="close-popup">Close</button>' ); } link = $('.popup em a'); href = $(link).attr('href'); target = $(link).attr('target'); $(link).closest('em').hide(); } function handleClick() { closePopup(link); if (target == '_blank') { window.open(href); } else { window.location.href = href; } } function closePopup(elem) { $(elem).closest(".popup").addClass('slide-out'); getCookies("popup"); var text = $(elem).closest(".popup").text(), num = popupCookies.length + 1; var date = new Date(), expires = "expires="; date.setDate(date.getDate() + 1); expires += date.toGMTString(); document.cookie = "popup" + num + "='" + text + "; " + expires + "; path=/"; console.log(document.cookie); }</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function () { $('#NAV .navbar-default ul.nav>li').each(function () { navAnchor = $(this).find('>a'); navText = $(navAnchor).text(); megaMenu = $(this).find('>ul.megamenu>li:first-of-type'); menuTitle = '<h6>' + navText + ' </h6>'; $(menuTitle).prependTo(megaMenu); }); $('#NAV #MPButtonBar ul.nav .megamenu').each(function () { firstChildLi = $(this).find('>li:first-child'); notFirstChildUl = $(this).find('>li:not(:first-child) ul'); $(firstChildLi).append(notFirstChildUl); }); $('.dropdown-header + .child').wrap('<ul class="children" />'); $('.children').each(function () { var self = $(this); while ($(self).find('+ *').hasClass('child')) { $(self).append($(self).find('+ .child')); } $(self).appendTo($(self).prev()); }); // var dropdownNav = document.querySelectoAll('.megamenu .dropdown-header'); // $(dropdownNav).hover(function () { // var self = $(this); // $(self).toggleClass('open'); // }); $('.megamenu .dropdown-header').hover(function () { $(this).toggleClass('open'); }); // $('.megamenu .dropdown-header').mouseover(function () { // $(this).addClass('open'); // }); // $('.megamenu .dropdown-header').mouseout(function (){ // $(this).removeClass('open'); // }); while ($('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul').is(':parent')) { $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul').each(function () { firstChild = $(this).find('>li:first-child'); $(firstChild).appendTo($(this).parent()); }); } $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child').each(function () { li = $(this).find('>li'); $(li).wrapAll('<ul />'); }); // $('.megamenu .dropdown-header').click(function () { // toggleOpen(); // $(this).parent().parent().parent().addClass('open'); // }); $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul:empty').remove(); $('#NAV #MPButtonBar ul.nav .megamenu>li:empty').remove(); var navHeight = $('#NAV').height(); $('#MPOuter').css('padding-top', parseInt(navHeight) - 105); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(document).ready(function () { // page content $('.user-groups').wrapAll('<div class="container" />'); $('.horizontal ul li').addClass('col-md-4'); $('.section6').parent('.row').addClass('connect-bg'); $('.connect-bg').wrapInner('<div class="container" />'); $('.audience .section16').addClass('bg-blue').wrapInner('<div class="container" />'); $('.interior #PageTitleH1').prependTo('.banner-page .section1'); if ($('#MainCopy_ContentWrapper').hasClass('banner-page')) { $('body').addClass('banner-page'); } // header $('.search-field-wrapper, .join-renew, .make-a-gift ').wrapAll('<div class="row row-wide clearfix header-content " />'); $('.header-content').insertBefore('.HLWelcome.HLWelcomeHeader'); $('.search-field-wrapper, .join-renew, .make-a-gift').wrapAll('<div class="col-md-12 " />'); $('#MPAuxNav ul.level1 li a[href*="subscribe-btn"]').appendTo('.header-content .col-md-12'); $('.header-content').prepend('<button type="button" class="nav-toggle" onclick="toggleMenu();" aria-label="close menu"><i class="far fa-bars"></i></button>'); $('.profile-link-btn a').addClass('btn btn-sm inline alert-warning').appendTo('#ProfileContainer .welcome-links'); }); function toggleMenu() { if ($('.header-content').hasClass('open')) { closeMenu(); } else { openMenu(); } } function closeMenu() { $('.header-content').removeClass('open'); } function openMenu() { $('.header-content').addClass('open'); }</script> </div><div class="ContentItemHtml"><div class="HtmlContent"><p> <script data-cfasync="false">(function(w,i,s,e){window[w]=window[w]||function(){(window[w].q=window[w].q||[]).push(arguments)};window[w].l=Date.now();s=document.createElement('script');e=document.getElementsByTagName('script')[0];s.defer=1;s.src=i;e.parentNode.insertBefore(s, e)})('wisepops', 'https://wisepops.net/loader.js?v=3&h=aPXRcreuQM');</script> </p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"> <p> <script type="text/javascript"> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='https://static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('config','o4hgv');</script> </p> </div><div class="HtmlFooter"></div></div> <div id="MPimage" class="MPimage"> <div id="mainskiplinkholder" class="skiplinkholder"><a id="skiplink" href="#MPContentArea">Skip to main content (Press Enter).</a></div> <div id="MPheader" class="MPheader"> <div class="row"> <div class="col-md-12"> <div class="pull-right"> <div class="inline"> <div class='HLWelcome HLWelcomeHeader'> <script type="text/javascript"> $(document).ready(function () { $('.Picture_Profile').tipTip({ delay: 200 }); }); function toggleHelp() { if ($("ul#CompleteBarHelpContainer").is(":visible")) { $("ul#CompleteBarHelpContainer").hide(); } else { $("ul#CompleteBarHelpContainer").show(); } } // Added as onClick for logoutLink on back end if opted in // On logout, removes the CREST API cookie that was added on login, whose value is a token used to authenticate to the API function removeApiToken(tenantKey, token) { hl_webapi_remove_cookie(tenantKey, token, tenantKey, "HLApiPassThrough"); window.location = ""; return false; } $(document).on('click', "span.CompleteBarClose", function (e) { e.stopPropagation(); toggleHelp(); $(".btn-group").find('button#BtnShowProfile').dropdown('toggle'); }); </script> <div class="EndDiv"> </div> <div id="Welcome_NotLoggedIn" class="Login"> <a id="Welcome_LoginLink" class="btn btn-primary" qa-id="login-link" href="https://sitc.execinc.com/HigherLogic/HLLoginRedirect.aspx?Redirect=https%3a%2f%2fwww.sitcancer.org%2fadvocacy%2fcrisis-in-clinical-research">Sign in</a> </div> </div> </div> </div> <div class="pull-right"> <div id="auxskiplinkholder" class="skiplinkholder"> <a id="auxskiplink" href="#Logo">Skip auxiliary navigation (Press Enter).</a> </div> <div id="MPAuxNav" class="inline vertical-align-middle"> <div CssSelectorClass="MPAuxNav" id="AuxMenu"> <ul class="level1"> <li><a class="level1 MPAuxNav" href="/subscribe-btn">Subscribe</a></li> </ul> </div> </div> </div> </div> </div> <div id="Logo" class="row" role="banner"> <div class="col-md-12"> <div id="DesktopLogoDiv" class="LogoImg inline"> <a href='https://www.sitcancer.org/home' style=''> <img src='https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-pms-horz_430px.png' alt="Society for Immunotherapy of Cancer (SITC) logo. This will take you to the homepage" /></a> </div> <div id="PhoneLogoDiv" class="LogoImg inline"> <a href='' style=''> <img src='//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/sitc_log_color_250px.png' alt="Society for Immunotherapy of Cancer (SITC) logo. This will take you to the homepage" /></a> </div> <div id="SloganText" class="SloganText inline"></div> </div> </div> </div> </div> <div style="clear: both"></div> <div class="ContentItemHtml"> <div class="HtmlContent"><script type="text/javascript" src="https://sitc.sitcancer.org/_include/js/util.js?v=2"></script></div><div class="HtmlFooter"></div></div> </div> </div> <div id="NAV" class="row traditional-nav"> <div class="col-md-12"> <div id="navskiplinkholder" class="skiplinkholder"><a id="navskiplink" href="#MPContentArea">Skip main navigation (Press Enter).</a></div> <div id="MPButtonBar"> <nav class="navbar navbar-default"> <div class="navbar-header"> <button type="button" class="navbar-toggle" data-toggle="collapse" data-target=".navbar-ex1-collapse, .icon-bar-start"> <span class="sr-only">Toggle navigation</span> <span class="icon-bar-start"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> </div> <div class="collapse navbar-collapse navbar-ex1-collapse"> <div class="row"> <div class="col-md-12 "> <ul class="nav navbar-nav"> <li class="dropdown menu-large" ><a href="/education" id="megaanchor1" class="dropdown-toggle" data-toggle="dropdown">Educational & Scientific Programs <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu11" class="col-sm-4"><ul><li ><a href="/education/connect-ed" target="_blank">ConnectED</a></li><li ><a href="/education/winterschool-2025">Cancer Immunotherapy Winter School</a></li><li ><a href="/education/drug-development-summit">SITC Immuno-Oncology Drug Development Summit</a></li><li class="dropdown-header"><a href="/education/webinars-online">Webinars and Online Education</a></li><li class="child"><a href="/education/webinars-online/aci-webinars">Advances in Cancer Immunotherapy (ACI) Webinars</a></li><li class="child"><a href="/education/webinars-online/computational">AI in IO: SITC-NCI Computational IO Series</a></li><li class="child"><a href="/education/webinars-online/ibcg">Definitions, End Points, and Clinical Trial Designs for Bladder Cancer</a></li><li class="child"><a href="/education/webinars-online/expanding-access">Expanding Access to Cellular and Bispecific Therapies</a></li><li class="child"><a href="/education/webinars-online/glyco-immunology-webinar">2024 Glyco-Immunology Webinar Series</a></li><li class="child"><a href="/education/webinars-online/immune-exclusion-virtual-summit">Immune Exclusion Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/immunomodulation-vs">Immunomodulation of ADCs Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/immunoprevention">Immunoprevention Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/increasing-access-to-io-a-global-webinar-series">Increasing Access to IO: A Global Webinar Series</a></li><li class="child"><a href="/education/webinars-online/intralesional-vs">Intralesional Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/neuro-vs">Neuro Immuno-Oncology Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/cpg-online-edu">SITC Clinical Practice Guidelines Online Education</a></li><li class="child"><a href="/education/webinars-online/cancer-io-deep-dive">Targets for Cancer IO: A Deep Dive Series</a></li><li ><a href="/education/cfp">Call for Proposals</a></li></ul></li><li id="megamenu12" class="col-sm-4"><ul><li class="dropdown-header"><a href="/education/annualmeeting">Annual Meeting & Pre-Conference Programs</a></li><li class="child"><a href="/education/annualmeeting/39th-annual-meeting" target="_blank">39th Annual Meeting & Pre-Conference Programs</a></li><li class="child"><a href="/education/annualmeeting/archive">Past and Future Annual Meetings & Pre-Conference Programs</a></li><li ><a href="/education/collaborative">Collaborative Education Programs</a></li><li ><a href="/education/patient-survivor-resources">Patient and Survivor Education and Resources</a></li><li class="dropdown-header"><a href="/education/workshops">Workshops</a></li><li class="child"><a href="/education/workshops/tme-workshop">Tumor Immune Microenvironment: A Holistic Approach</a></li><li class="child"><a href="/education/workshops/immune-targeting-workshop">Surfaceome Virtual Workshop</a></li><li class="child"><a href="/education/workshops/bispecificworkshop">Bispecific T cell Engagers Virtual Workshop</a></li><li class="child"><a href="/education/workshops/cytokines-workshop">Cytokines in Cancer Immunotherapy Virtual Workshop</a></li></ul></li><li id="megamenu13" class="col-sm-4"><ul><li ><a href="/education/aci">Advances in Cancer Immunotherapy</a></li><li ><a href="/education/sitc-biotech">SITC Biotech Initiative</a></li><li class="dropdown-header"><a href="/education/spring-scientific">Spring Scientific</a></li><li class="child"><a href="/education/spring-scientific/2025-spring-scientific">2025 Spring Scientific</a></li><li class="child"><a href="/education/spring-scientific/springscientificprograms">Past and Future Spring Scientific Programs</a></li><li ><a href="/education/events">Calendar of Events</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/professional-development" id="megaanchor2" class="dropdown-toggle" data-toggle="dropdown">Professional Development & Training <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu21" class="col-sm-6"><ul><li ><a href="/professional-development/certificate">Certificate in Cancer Immunotherapy</a></li><li ><a href="/professional-development/professional-interest-communities">Professional Interest Communities</a></li><li ><a href="/professional-development/fellowships">Fellowships</a></li><li class="dropdown-header"><a href="/professional-development/win2">Women in Cancer Immunotherapy Network (WIN)</a></li><li class="child"><a href="/professional-development/win2/win">Women in Cancer Immunotherapy Network 2024</a></li><li class="child"><a href="/professional-development/win2/win-community">Women in SITC Community</a></li><li ><a href="/professional-development/early-career-scientist">Early Career Scientist (ECS) Committee</a></li></ul></li><li id="megamenu22" class="col-sm-6"><ul><li class="dropdown-header"><a href="/professional-development/clinical-trials-training-resources">Clinical Trials Training and Resources</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/scion">SITC Clinical Immuno-Oncology Network (SCION) Workshop</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/mvp3">Maximizing the Value of Phase III Trials in Immuno-Oncology</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/ici-related-adverse-events-terminology-definitions">ICI-related Adverse Events Terminology Definitions</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/bladder-cancer-trial-design">Definitions, End Points, and Clinical Trial Designs for Bladder Cancer</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/iict-paper">Intratumoral Immunotherapy Clinical Trial (IICT) Design</a></li><li ><a href="/professional-development/nci-immunotherapy-fellowship">NCI Immunotherapy Fellowship</a></li><li class="dropdown-header"><a href="/professional-development/sitc-sparkathon">SITC Sparkathon</a></li><li class="child"><a href="/professional-development/sitc-sparkathon/sparkathon-2025">Sparkathon 2025</a></li><li class="child"><a href="/professional-development/sitc-sparkathon/matching-donation-challenge">Support Sparkathon</a></li><li class="dropdown-header"><a href="/professional-development/other-resources">Other Resources</a></li><li class="child"><a href="/professional-development/other-resources/events2">Calendar of Events</a></li><li class="child"><a href="/professional-development/other-resources/path-sitc-leadership">Path to SITC Leadership</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/research" id="megaanchor3" class="dropdown-toggle" data-toggle="dropdown">Publications & Guidelines <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu31" class="col-sm-6"><ul><li class="dropdown-header"><a href="/research/jitc-2">Journal for ImmunoTherapy of Cancer</a></li><li class="child"><a href="/research/jitc-2/jitc">About JITC</a></li><li class="child"><a href="/research/jitc-2/become-a-reviewer">Become a Reviewer</a></li><li class="child"><a href="/research/jitc-2/for-authors2" target="_blank">For Authors</a></li><li class="child"><a href="/research/jitc-2/the-editors">From the Editors</a></li><li class="child"><a href="/research/jitc-2/jitc-collections-and-special-issues">JITC Collections and Special Issues</a></li><li class="dropdown-header"><a href="/research/sitc-immunotherapy-books">SITC Immunotherapy Books</a></li><li class="child"><a href="/research/sitc-immunotherapy-books/sitcs-guide-managing-immunotherapy-toxicity">SITC's Guide to Managing Immunotherapy Toxicity Textbook</a></li><li class="child"><a href="/research/sitc-immunotherapy-books/cancer-immunotherapy-principles-practice">Cancer Immunotherapy Principles and Practice Textbook, 2nd Ed.</a></li><li ><a href="/research/sitc-scientific-publications-news">SITC Scientific Publications News</a></li></ul></li><li id="megamenu32" class="col-sm-6"><ul><li class="dropdown-header"><a href="/research/cancer-immunotherapy-guidelines">SITC Clinical Practice Guidelines</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg">Clinical Practice Guidelines</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/webinars">Clinical Practice Guidelines Online Education</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg-app">Clinical Practice Guidelines Mobile App</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg-news">SITC Cancer Immunotherapy Guideline News</a></li><li ><a href="/research/patient-resource-guides">Patient Resource Guides</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/advocacy" id="megaanchor4" class="dropdown-toggle" data-toggle="dropdown">Access & Advocacy <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu41" class="col-sm-6"><ul><li ><a href="/advocacy/new-page">SITC Immuno-oncology Drug Development Summit</a></li><li class="dropdown-header"><a href="/advocacy/access-advocacy-summits-initiatives">Summits and Initiatives</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/io-surrogate-endpoints">IO Surrogate Endpoints Initiative</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/resistance">IO Resistance Initiative</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/release-criteria">Release Criteria Initiative</a></li><li ><a href="/advocacy/global-access">Global Immunotherapy Access</a></li><li ><a href="/advocacy/expanding-access-to-cellular-and-bispecific-therapies">Expanding Access to Cellular and Bispecific Therapies</a></li></ul></li><li id="megamenu42" class="col-sm-6"><ul><li ><a href="/advocacy/policy">Policy</a></li><li ><a href="/advocacy/advocacy-news">Advocacy News</a></li><li ><a href="/advocacy/crisis-in-clinical-research">Crisis in Clinical Research</a></li><li ><a href="/advocacy/patient-survivor-resources">Patient & Survivor Education & Resources</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/membership" id="megaanchor5" class="dropdown-toggle" data-toggle="dropdown">Membership <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu51" class="col-sm-4"><ul><li ><a href="/membership/2024-sitc-election">2024 SITC Election</a></li><li ><a href="/membership/connect-a-colleague">Connect-a-Colleague</a></li><li class="dropdown-header"><a href="/membership/volunteer2">Volunteer</a></li><li class="child"><a href="/membership/volunteer2/volunteer">Volunteer with SITC</a></li></ul></li><li id="megamenu52" class="col-sm-4"><ul><li class="dropdown-header"><a href="/membership/academy-immuno-oncology">Academy of Immuno-Oncology</a></li><li class="child"><a href="/membership/academy-immuno-oncology/faio">About the Academy</a></li><li ><a href="/membership/corporate-membership">Corporate Membership</a></li></ul></li><li id="megamenu53" class="col-sm-4"><ul><li ><a href="/membership/details">Benefits, Categories & Application</a></li><li class="dropdown-header"><a href="/membership/members-only2">Members Only</a></li><li class="child"><a href="/membership/members-only2/member-directory">SITC Member Directory</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/funding" id="megaanchor6" class="dropdown-toggle" data-toggle="dropdown">Support SITC <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu61" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/forward-fund">The Forward Fund</a></li><li class="child"><a href="/funding/forward-fund/moving-the-field-forward">Moving the Field Forward</a></li><li class="child"><a href="/funding/forward-fund/making-a-difference">Making a Difference</a></li><li class="dropdown-header"><a href="/funding/named-funds-and-awards2">Named Funds and Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/young-investigator">Early Career Scientist Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/smalley">Richard V. Smalley Memorial Award and Lectureship</a></li><li class="child"><a href="/funding/named-funds-and-awards2/rosenberg">Steven A. Rosenberg Scholars Award</a></li><li class="child"><a href="/funding/named-funds-and-awards2/weber">Dr. Weber Remembrance Fund</a></li><li class="child"><a href="/funding/named-funds-and-awards2/techawards">Technology Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/mac-cheever">Martin "Mac" Cheever Travel Award Fund</a></li><li class="child"><a href="/funding/named-funds-and-awards2/sparkathon-accelerator">Sparkathon</a></li><li ><a href="/funding/the-checkpoints-band">The CheckPoints: SITC’s House Band</a></li></ul></li><li id="megamenu62" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/ways-make-gift">Ways to Make a Gift</a></li><li class="child"><a href="/funding/ways-make-gift/donate-online">Donate</a></li><li class="child"><a href="/funding/ways-make-gift/new-page2">Stocks and Securities</a></li><li class="child"><a href="/funding/ways-make-gift/new-page3">Estate and Planned Gifts</a></li><li class="dropdown-header"><a href="/funding/corporate-giving">Corporate Support and Giving Opportunities</a></li><li class="child"><a href="/funding/corporate-giving/corporate-giving">Corporate Giving Opportunities</a></li><li class="child"><a href="/funding/corporate-giving/corporate-membership">Corporate Membership</a></li><li class="child"><a href="/funding/corporate-giving/educational-grants">Educational Grants</a></li><li class="child"><a href="/funding/corporate-giving/sponsorship">Sponsorship & Advertising</a></li><li ><a href="/funding/merchandise">SITC Merchandise</a></li></ul></li><li id="megamenu63" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/honor-memorial">Honor and Memorial Gifts</a></li><li class="child"><a href="/funding/honor-memorial/in-honor">Make a Gift in Honor of a Loved One</a></li><li class="child"><a href="/funding/honor-memorial/in-memory">Make a Gift in Memory of a Loved One</a></li><li class="dropdown-header"><a href="/funding/donors-supporters">Our Donors and Supporters</a></li><li class="child"><a href="/funding/donors-supporters/2020-supporters813">2022 SITC Supporters</a></li><li class="child"><a href="/funding/donors-supporters/2021-forward-fund-donors"><em>Forward</em> Fund Donors</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/aboutsitc" id="megaanchor7" class="dropdown-toggle" data-toggle="dropdown">About SITC <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu71" class="col-sm-6"><ul><li ><a href="/aboutsitc/strategic-plan-2024-2026">Strategic Plan</a></li><li ><a href="/aboutsitc/awards">Awards and Recognition</a></li><li ><a href="/aboutsitc/career-connections">Career Connections</a></li><li class="dropdown-header"><a href="/aboutsitc/diversity-strategy">SITC’s DEI Strategy</a></li><li class="child"><a href="/aboutsitc/diversity-strategy/dei">Elevating a Rich Oncology Community: SITC’s DEI Strategic Plan</a></li><li class="child"><a href="/aboutsitc/diversity-strategy/virtual-roundtable">Virtual Roundtable on Diversity in Clinical Trial Enrollment</a></li><li ><a href="/aboutsitc/partnerships">Partnerships</a></li><li ><a href="/aboutsitc/contact-sitc">Contact SITC</a></li></ul></li><li id="megamenu72" class="col-sm-6"><ul><li ><a href="/aboutsitc/new-page">SITC Biotech Initiative</a></li><li ><a href="/aboutsitc/board">Board of Directors</a></li><li ><a href="/aboutsitc/get-involved">Committees, Task Forces and Professional Interest Communities</a></li><li ><a href="/aboutsitc/mission">Mission & Vision</a></li><li class="dropdown-header"><a href="/aboutsitc/media-room">Media Room</a></li><li class="child"><a href="/aboutsitc/media-room/sitc-press-releases">SITC Press Releases</a></li><li class="child"><a href="/aboutsitc/media-room/scientific-meeting-highlights">Scientific Meeting Highlights from SITC</a></li><li class="child"><a href="/aboutsitc/media-room/immunemonitor-archive">Immune Monitor Archive</a></li><li class="child"><a href="/aboutsitc/media-room/jitc-digest-archive">JITC Digest Archive</a></li><li class="child"><a href="/aboutsitc/media-room/cancer-immunotherapy-month">Cancer Immunotherapy Month</a></li><li ><a href="/aboutsitc/policies">SITC Policies</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/connect" id="megaanchor8" class="dropdown-toggle" data-toggle="dropdown">The Connect Community <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu81" class="col-sm-12"><ul><li ><a href="/connect/create-account">Create Account</a></li><li ><a href="/connect/my-profile">My Profile</a></li><li ><a href="/connect/my-communities">My Communities</a></li><li ><a href="/connect/mylibraries">My Libraries</a></li><li ><a href="/connect/thesentinel" target="_blank">The Sentinel - SITC Blog</a></li></ul></li></li></ul> </ul> </div> </div> </div> </nav> </div> <div class="MenuBarUnderline"> </div> </div> </div> </div> </div> <div id="MPOuter" class="row siteFrame "> <div id="ContentColumn" class="col-md-12">  <div id="BreadCrumb" class="BreadCrumb"> </div> <div id="MPContentArea" class="MPContentArea no-pageTitle-padding" role="main"> <h1 id="PageTitleH1" qa-attribute="PageTitleH1" style="display: none;" aria-hidden="true"> Crisis in Clinical Research </h1> <input type="hidden" name="ctl00$DefaultMasterHdnCommunityKey" id="DefaultMasterHdnCommunityKey" value="00000000-0000-0000-0000-000000000000" /> <div id="FlashMessageContainer"> </div> <div id="MainCopy_ContentWrapper"> <div class="row row-full "><div class="col-md-12 section1"><div class="ContentItemHtml"> <div class="HtmlContent"><style> * { box-sizing: border-box; } .crisis-banner-bckgrnd { background: linear-gradient(to left, transparent, #1D4F91), url("https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Policy/Crisis_in_Clinical_Research_Banner.png"); background-size: cover; background-position: center; margin-left: -15px; margin-right: -15px; } .crisis-banner-container { display: flex; flex-direction: row; font-size: 14px; text-align: left; max-width: 1200px; justify-content: center; margin: auto; padding-top: 60px ; padding-bottom: 60px ; line-height: 1.8em; } .crisis-banner-logo { flex: 30%; margin: 5px; color: #ffffff; justify-content: center; align-items: center; } .crisis-banner-text { flex: 70%; margin: 5px; color: #ffffff; font-weight: 800; padding-left: 15px; } /* Style the crisis-navbar */ #crisis-navbar { background-color: #64A70B; margin-left: -15px; margin-right: -15px; display: flex; overflow: auto; white-space: nowrap; align-items: center; padding-left: 10px; justify-content: center; } /* crisis-navbar links */ #crisis-navbar a { display: flex; flex-direction: row; color: #f2f2f2; padding: 16px; text-decoration: none; font-weight: 700; text-transform: uppercase; font-size: 14px; } #crisis-navbar a:hover { color: #1D4F91; } .crisis-banner-button { border-radius: 30px; background-color: #64A70B; color: white; padding: 8px 20px; text-align: center; font-family: calibri, arial, sans-serif; text-decoration: none; font-weight: 900; letter-spacing: 1px; text-transform: uppercase; display: flex; font-size: 14px; margin: 2px 2px; transition-duration: 0.4s; cursor: pointer; float: left; transition: 0.3; } .crisis-banner-button:hover { color: white; background-color: #64A70B; opacity: 0.9; box-shadow: 0px 4px 14px rgb(0 0 0 / 7%); } /* Responsive layout - makes a one column-layout instead of two-column layout */ @media (max-width: 700px) { .crisis-banner-container { flex-direction: column; padding: 0px 15px; } #crisis-navbar { justify-content: space-between; } } </style> <div class="crisis-banner-bckgrnd"> <div class="crisis-banner-container"> <div class="crisis-banner-text"> <h1><strong><a id="dei-top"></a>Crisis in Clinical Research</strong></h1> <h5>#SITCresearchsolutions</h5> <p><span style="font-size: 12pt;"><strong>The Society for Immunotherapy of Cancer (SITC) is convening key oncology experts from academia, industry and government, including the FDA and NCI, to lead a national conversation around what’s become a crisis in clinical research.</strong></span></p> <p><span style="font-size: 12pt;"><strong>Through discussions with key stakeholders in academia, industry, and government, it has become apparent that this crisis is having a significant negative impact on cancer drug development and patient care, which threatens advancement of the field for years to come. Leveraging its convening powers, SITC is leading the national conversation around this crisis and is committed to finding collaborative solutions that ultimately reduce the administrative burden of clinical trials while increasing patient access to safe and effective clinical trials.</strong></span></p> </div> <div class="crisis-banner-logo"></div> </div> </div> <div id="crisis-navbar"><a href="#crisis-summit">Virtual Summit</a><a href="#crisis-overview">Summit Overview</a><a href="#crisis-outcomes">Outcomes & Next Steps</a><a href="#crisis-organizers">Organizers</a><a href="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Policy/Crisis_in_Clinical_Research__Executive_Summary_Press_Release_FINAL_docx.pdf" target="_blank" rel="noopener">Press Release</a><a href="#crisis-resources">Clinical Research Resources</a></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section2"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 25px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 25px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><strong><a id="crisis-summit"></a>Virtual Summit</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section3"><div class="ContentItemHtml"> <div class="HtmlContent"><p><span style="font-size: 12pt;">The SITC Crisis in Clinical Research Virtual Summit was a successful initial step in addressing the crisis in clinical research that brought oncologists, administrators, the NCI, the FDA, pharmaceutical companies, contract research organizations, and other major oncology professional organizations together to further delineate the current staffing and administrative issues for oncology clinical trials. The group also considered alternative clinical trials administrative models to reduce the current burden.</span><br /><br /><span style="font-size: 12pt;">Finding solutions to address current clinical trials staffing issues will be imperative for optimal patient care, advancing drug development, and maintaining financial feasibility of academic medical centers.</span><br /><br /><span style="font-size: 12pt;">Attendees were able to:</span></p> <ul> <li><span style="font-size: 12pt;">Hear vital perspectives from leading experts from academic medical centers, major community cancer centers, contract research organizations, the FDA, and the NCI detailing the crisis</span></li> <li><span style="font-size: 12pt;">Listen to panel discussions on the most significant hurdles facing clinical trial administration</span></li> <li><span style="font-size: 12pt;">Get involved in the discussion through chat functionality</span></li> </ul></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section4"><div class="ContentItemHtml"> <div class="HtmlContent"><iframe style="border: 1px solid lightgray; width: 100%; height: 400px;" allowfullscreen="allowfullscreen" scrolling="no" class="fp-iframe" src="https://heyzine.com/flip-book/72c158c47c.html"></iframe> <br /> <p style="text-align: center;"><a href="https://www.sitcancer.org/advocacy/crisis-in-clinical-research/crisis-in-clinical-research-schedule" class="btn btn-standard">RECORDING & PANELISTS</a></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section5"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><strong><a id="crisis-overview" target="_blank"></a>Summit Overview</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section6"><div class="ContentItemHtml"> <div class="HtmlContent"><h3>Problem Statement</h3> <p>There is a national crisis slowing clinical research due to staffing shortages, administrative burden and current clinical trial business models. If the crisis is not rapidly addressed, the field of oncology faces a significant threat to patient treatment access and novel drug development that can affect the clinical landscape for years to come.</p> <h3>SITC’s Call to Action and Summit Overview</h3> <p>Based on preliminary discussions with various stakeholders concerning the significance of the crisis, The Society for Immunotherapy of Cancer (SITC) hosted the Crisis in Clinical Research Virtual Summit on Wednesday, Aug. 17, from 10:00 a.m.–3:30 p.m. EDT. The summit was designed as a free, public event that featured expert panel discussions, invited speakers, and attendee question and answer periods. In all, the multi-stakeholder virtual summit convened over 600 attendees and 30 panelists demonstrating the critical need across the field for solutions pertaining to the crisis. Attendees included oncologists, administrators, the National Cancer Institute (NCI), the US Food and Drug Administration (FDA), pharmaceutical companies, contract research organizations (CRO) and other major oncology professional organizations.</p></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section7"><div class="ContentItemHtml"> <div class="HtmlContent"><h3><a id="crisis-goals" target="_blank"></a>Summit Goals</h3> <p>The summit’s primary objective was to define actionable solutions towards addressing the current staffing shortages, administrative issues and process inefficiencies facing oncology clinical trials, as well as consider alternative clinical trials administrative models to reduce the current burden.</p> <h3>Professional Roles of Attendees</h3> <p><i>*Attendees allowed to select multiple roles<br /><br /><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Policy/Crisis_AttendeeGraph.png" alt="Crisis_AttendeeGraph.png" data-mce-hlimagekey="4892cdda-8743-c259-6960-1f72c8ba0b50" data-mce-hlselector="#TinyMceContent_93a792e6-46d6-5c0b-e6e6-d65e1f318730-tinyMceHtml" class="img-responsive" style="float: left; display: inline-block;" /></i></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section8"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><strong>Fireside Chat with Dr. Hwu, Dr. Emens, and Dr. Sznol </strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-4 section9"><div class="ContentItemHtml"> <div class="HtmlContent">SITC Presidents Dr. Mario Sznol (2019-2020), Dr. Patrick Hwu (2021-2022) and Dr. Leisha Emens (2023-2024) provide an overview of the Crisis in Clinical Research and SITC's role in addressing the ongoing challenges in this 2022 SITC Annual Meeting Update Session. Discussions include how staffing and inefficiencies in clinical research are limiting advancement of critical therapies and how SITC will work to continue advocacy and collaborative outreach to achieve field-wide solutions.</div><div class="HtmlFooter"></div></div></div><div class="col-md-8 section10"><div class="ContentItemHtml"> <div class="HtmlContent"><video width="700" height="350" style="width: 100%;" controls="controls" poster="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Crisis/CrisisFiresideChat_Screenshot.png"> <source src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Crisis/Crisis_AM_Update_Master_1.mp4" type="video/mp4" /></video></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section11"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><style> * { box-sizing: border-box; } .crisisoutcomes-background { background-color: #E3F4FF; border-radius: 15px; } .crisisoutcomes-banner-container { display: flex; flex-direction: row; font-size: 14px; text-align: left; max-width: 1200px; justify-content: center; margin: auto; padding-top: 10px ; padding-bottom: 10px ; } .crisisoutcomes-banner-logo { flex: 45%; margin: 5px 5px; color: black; justify-content: center; align-items: center; } .crisisoutcomes-banner-text { flex: 50%; margin: 0px 5px; color: black; padding: 15px; word-wrap: break-word; } .crisisoutcomes-banner-button { border-radius: 30px; background-color: #64A70B; color: white; padding: 8px 20px; text-align: center; font-family: calibri, arial, sans-serif; text-decoration: none; font-weight: 900; letter-spacing: 1px; text-transform: uppercase; display: flex; font-size: 14px; margin: 2px 2px; transition-duration: 0.4s; cursor: pointer; float: left; transition: 0.3; } .crisisoutcomes-banner-button:hover { color: white; background-color: #64A70B; opacity: 0.9; box-shadow: 0px 4px 14px rgb(0 0 0 / 7%); } /* Responsive layout - makes a one column-layout instead of two-column layout */ @media (max-width: 650px) { .crisisoutcomes-banner-container { flex-direction: column; padding: 0px 15px; margin: 10px; } .crisisoutcomes-banner-text { margin: 10px; } } </style> <h2><strong><a id="crisis-outcomes"></a>Summit Outcomes and Next Steps</strong></h2> <h3>Summit Takeaways</h3> <p>Summit attendees formalized possible solutions towards addressing the crisis and clinical research inefficiencies throughout the program. At the conclusion of the meeting, SITC was provided four key efforts that would create momentum in this arena:</p> <div class="crisisoutcomes-banner-container"> <div class="crisisoutcomes-banner-text"><hr style="height: 2px; border-width: 0; color: #64a70b; background-color: #64a70b; ; max-width: 100px; margin-left: 0;" /> <h3><strong>Standardization and Centralization of Clinical Research Resources</strong></h3> <ul> <li style="margin-bottom: .5em;">Develop consensus on structured data inputs</li> <li style="margin-bottom: .5em;">Standardize clinical research contracting and budgeting language</li> <li style="margin-bottom: .5em;">Adopt standard timelines across the ﬁeld for implementation of EDC automations</li> <li style="margin-bottom: .5em;">Implement consistent EMR builds and compatibilities</li> <li>Incorporate and accept centralized IRBs and SRCs</li> </ul> </div> <div class="crisisoutcomes-banner-text"><hr style="height: 2px; border-width: 0; color: #64a70b; background-color: #64a70b; ; max-width: 100px; margin-left: 0;" /> <h3><strong>Cross-institutional Data Availability</strong></h3> <ul> <li style="margin-bottom: .5em;">Collect clinical research accrual and activation data to drive future innovation</li> <li style="margin-bottom: .5em;">Expand upon current data collection efforts</li> <li style="margin-bottom: .5em;">Promote impartial and accepted data sharing culture across institutions and stakeholders</li> </ul> </div> </div> <div class="crisisoutcomes-banner-container"> <div class="crisisoutcomes-banner-text"><hr style="height: 2px; border-width: 0; color: #64a70b; background-color: #64a70b; ; max-width: 100px; margin-left: 0;" /> <h3><strong>Maximizing Efficiency Across Clinical Research Operations</strong></h3> <ul> <li style="margin-bottom: .5em;">Embrace automation</li> <li style="margin-bottom: .5em;">Incorporate business‐like operations within clinical research workstreams</li> <li style="margin-bottom: .5em;">Perform work in parallel towards identifying potential efficiencies/inefficiencies</li> <li style="margin-bottom: .5em;">Reduce silo’s and streamline communications across stakeholders</li> <li>Develop processes that maximize personal and professional success for the available workforce</li> </ul> </div> <div class="crisisoutcomes-banner-text"><hr style="height: 2px; border-width: 0; color: #64a70b; background-color: #64a70b; ; max-width: 100px; margin-left: 0;" /> <h3><strong>Diversification of Clinical Research Sites and Populations</strong></h3> <ul> <li style="margin-bottom: .5em;">Expand access of clinical trials to underrepresented communities</li> <li style="margin-bottom: .5em;">Increase patient education towards enhancing clinical trial acceptance</li> <li style="margin-bottom: .5em;">Provide education to community centers towards becoming fully equipped clinical research sites</li> <ul></ul> </ul> </div> </div> <h3>SITC’s Next Steps</h3> <p>As a direct followup to this impactful summit, SITC is actively working with volunteers on formulating direct actions to address the four identified efforts. Immediately, published works are in development to provide awareness to the current crisis as well as to provide expanded insight concerning summit conclusions. Additionally, SITC has emphasized collaboration as a critical element of effective response to the crisis and is actively communicating with like‐minded groups towards developing impactful solutions. Overall, SITC is committed to serving as a leader in addressing the crisis facing clinical research. Further information on how the attendees came to these recommendations can be found below in a detailed report of each talk and panel that occurred throughout the summit.</p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><style> @media (min-width: 640px) { .ul-crisis { columns: 2; list-style-type: disc; -webkit-columns: 2; -moz-columns: 2; display: flex; flex-wrap: wrap; } .li-crisis { width: 50%; } } </style> <h2><strong><a id="crisis-organizers"></a>Summit Organizers</strong></h2> <ul class="ul-crisis"> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Leisha Emens, MD, PhD – Co-Chair</strong><br /><em>UPMC Hillman Cancer Center</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Mario Sznol, MD – Co-Chair</strong><br /><em>Yale University</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Marc Ernstoff, MD</strong><br /><em>National Cancer Institute</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Michael S. Gordon, MD</strong><br /><em>HonorHealth</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>David Hong, MD</strong><br /><em>MD Anderson Cancer Center</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Krystyna Kowalczyk</strong><br /><em>OncoBay</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Stephanie Terzulli, PhD</strong><br /><em>Memorial Sloan Kettering Cancer Center</em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>David Feltquate, MD, PhD</strong><em><strong><em><br /></em></strong>Palleon Pharma </em></li> <li class="li-crisis" style="margin-bottom: .8em;"><strong>Marc Theoret, MD</strong><br /><em>US Food and Drug Administration</em></li> <li class="li-crisis"><strong>Kristin Hege, MD</strong><br /><em>Bristol Myers Squibb</em></li> </ul></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><strong><a id="crisis-resources"></a>Clinical Research Resources</strong></h2> <h3><strong><span style="font-size: 14pt;"></span></strong><span style="font-size: 14pt;">FDA Guidance</span></h3> <ul> <li><span style="font-size: 12.0pt; color: #201f1e;"><a href="https://www.fda.gov/media/116754/download" target="_blank" rel="noopener">Oversight of Clinical Investigations – A Risk-Based Approach to Monitoring</a><span style="color: #201f1e !important;"></span></span></li> <li><span style="font-size: 12pt;"><a href="https://www.fda.gov/media/85183/download" target="_blank" rel="noopener">Electronic Source Data in Clinical Investigations</a></span></li> <li><span style="font-size: 12.0pt; color: #201f1e;"><span style="color: #201f1e !important;"><a href="https://www.fda.gov/media/116850/download" target="_blank" rel="noopener">Use of Electronic Informed Consent Questions and Answers</a></span><span style="color: #201f1e !important;"></span></span></li> <li><span style="font-size: 12.0pt; color: #201f1e;"><span style="color: #201f1e !important;"><a href="https://www.fda.gov/media/97567/download" target="_blank" rel="noopener">Use of Electronic Health Record Data in Clinical Investigations Guidance for Industry</a> </span><span style="color: #201f1e !important;"></span></span></li> <li><span style="font-size: 12.0pt; color: #201f1e;"><span style="color: #201f1e !important;"><a href="https://www.fda.gov/media/136238/download" target="_blank" rel="noopener">Conduct of Clinical Trials of Medical Products During the COVID-19 Public Health Emergency</a></span><span style="color: #201f1e !important;"></span></span></li> <li><span style="font-size: 12.0pt; color: #201f1e;"><span style="color: #201f1e !important;"><a href="https://www.fda.gov/media/155022/download" target="_blank" rel="noopener">Digital Health Technologies for Remote Data Acquisition in Clinical Investigations</a></span></span></li> <li><span style="font-size: 12pt;"><a href="https://www.fda.gov/media/152503/download" target="_blank" rel="noopener">Real-World Data: Assessing Electronic Health Records and Medical Claims Data To Support Regulatory Decision Making for Drug and Biological Products</a></span></li> <li><a href="https://www.fda.gov/media/154714/download" target="_blank" rel="noopener"><span style="font-size: 12pt;">Considerations for the Use of Real-World Data and Real-World Evidence to Support Regulatory Decision-Making for Drug and Biological Products</span></a></li> <li><span style="font-size: 12pt;"><a href="https://www.fda.gov/about-fda/fda-organization/oncology-center-excellence" target="_blank" rel="noopener">Oncology Center of Excellence</a></span></li> </ul> <h3><span style="font-size: 14pt;">Administration and Staffing Resources</span><span style="font-size: 12pt;"></span></h3> <ul> <li><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531899/" target="_blank" rel="noopener"><span style="font-size: 12pt;">The Critical Need for Academic Health Centers to Assess the Training, Support, and Career Development Requirements of Clinical Research Coordinators</span></a></li> </ul> <h3><span style="font-size: 14pt;">Other Resources</span></h3> <ul> <li><span style="font-size: 12pt;"><a href="https://www.jscdm.org/article/21/galley/50/view/" target="_blank" rel="noopener">Direct Data Extraction and Exchange of Local Labs for Clinical Research Protocols: A Partnership with Sites, Biopharmaceutical Firms, and Clinical Research Organizations</a></span></li> </ul></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section12"></div></div><div class="row row-wide clearfix "><div class="col-md-12 section13"></div></div><div class="row row-wide clearfix "><div class="col-md-6 section14"></div><div class="col-md-6 section15"></div></div><div class="row row-wide clearfix "><div class="col-md-12 section16"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div></div></div> <div id="MainCopy_extraPanel"> </div> </div> </div>  </div> </div> <div id="MPOuterFooter" class="row siteFrame"> <div id="FOOTER" class="col-md-12"> <div class="row row-wide clearfix "><div class="col-md-12 section1"><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><p style="text-align: center;"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-logo-white.png" style="float: left;"></p> <br></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><h3 class="editorSelectH3">Membership Links</h3> <p><a href="/membership/join">Join</a></p> <p><a href="https://sitc.execinc.com/edibo/Dues" target="_blank">Renew</a></p> <p><a href="/network/members">Member Directory</a></p> <p><a href="profile">My Profile</a></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><h3 class="editorSelectH3">Get Involved</h3> <p><a href="https://www.sitcancer.org/subscription" target="_blank" rel="noopener">Email Sign-up</a></p> <p><a href="volunteer">Volunteer</a></p> <p><a href="https://sitc.sitcancer.org/donate/?_ga=2.69149585.1866415943.1648138048-1544668743.1643294471">Support SITC</a></p> <p><a href="https://www.sitcancer.org/aboutsitc/contact-sitc">Contact Us</a></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml social-media col-md-3"> <div class="HtmlContent"><p><a href="https://www.facebook.com/sitcancer" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/facebook.png"> </a> <a href="https://twitter.com/sitcancer" target="_blank" rel="noopener noreferrer"> <img src="//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/TwitterX_Icons_for_Webpage_18px.png"> </a> <a href="https://www.linkedin.com/company/381116" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/linkedin.png"> </a> <a href="http://www.youtube.com/user/SITCancer?feature=watch" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/youtube.png"> </a></p></div><div class="HtmlFooter"></div></div></div></div> <div id="MPFooter" class="row"> <div class="Footer col-md-12"> <div id="FooterContent"> </div> <div id="MPBottomMenu" class="MPBottomMenu" align="center"> </div> </div> </div> <div class="row"> <div id="MPCopyright" class="col-md-12"> © 2024 Society for Immunotherapy of Cancer (SITC). All rights reserved. </div> </div> <div class="row row-wide clearfix "><div class="col-md-12 section1"><div class="ContentItemHtml col-md-6 sub-footer"> <div class="HtmlContent">555 East Wells Street, Suite 1100 | Milwaukee, WI | 53202-3823 | USA <br></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-6 sub-footer"> <div class="HtmlContent"><p style="text-align: right;">Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: <a href="mailto:info@sitcancer.org">info@sitcancer.org</a></p></div><div class="HtmlFooter"></div></div><div class="ContentUserControl"> <script charset="utf-8" src="http://dthis.com/js/300/addthis_widget.js#pubid=ra-586d5f6453e2f81d"></script> </div><div class="ContentItemHtml"> <div class="HtmlContent"><script type="text/javascript"> _linkedin_partner_id = "2569393"; window._linkedin_data_partner_ids = window._linkedin_data_partner_ids || []; window._linkedin_data_partner_ids.push(_linkedin_partner_id); </script> <script type="text/javascript"> (function(l) { if (!l){window.lintrk = function(a,b){window.lintrk.q.push([a,b])}; window.lintrk.q=[]} var s = document.getElementsByTagName("script")[0]; var b = document.createElement("script"); b.type = "text/javascript";b.async = true; b.src = "https://snap.licdn.com/li.lms-analytics/insight.min.js"; s.parentNode.insertBefore(b, s);})(window.lintrk); </script> <noscript> <img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=2569393&fmt=gif" /> </noscript></div><div class="HtmlFooter"></div></div></div></div> <div class="row"> <div class="col-md-12"></div> </div> </div> </div> <div id="MPFooterLink" class="row siteFrame"> <div class="col-md-12"> <div id="MPFooterLinkContent"> <a href="http://www.higherlogic.com" target="_blank">Powered by Higher Logic</a> </div> </div> </div> <div id="GlobalPopupContainer"> <div id="GlobalPopupContent" > <img ID="imgGlobalProcessing" alt="" src="https://d2x5ku95bkycr3.cloudfront.net/img/loading.gif" /> </div> </div> <script type="text/javascript"> //<![CDATA[ var _suppressGlobalPopupContainer = false; Sys.Application.add_load(GlobalApplicationLoadHandler); function GlobalApplicationLoadHandler(sender, args) { var prm = Sys.WebForms.PageRequestManager.getInstance(); if (!prm.get_isInAsyncPostBack()) { prm.add_initializeRequest(initRequest); prm.add_endRequest(endRequest); } } function initRequest(sender, args) { if (!_suppressGlobalPopupContainer) { hl_common_ui_blockUI(); } } function endRequest(sender, args) { hl_common_ui_unBlockUI(); }//]]> </script> <script type='text/javascript'>new Sys.WebForms.Menu({ element: 'AuxMenu', disappearAfter: 500, orientation: 'horizontal', tabIndex: 0, disabled: false });</script></form> </div> <script> $(document).ready(function () { var path = window.location.pathname; var lastChar = path.substr(-1); // Selects the last character if (lastChar != '?' && lastChar != '/' && lastChar != ';') { // If the last character is not a slash path = path + '/'; // Append a slash to it. } $('ul.navbar-nav a').each(function () { var myHref = $(this).attr('href').split("?")[0]; var lastChar2 = myHref.substr(-1); // Selects the last character if (lastChar2 != '?' && lastChar2 != '/' && lastChar2 != ';') { // If the last character is not a slash myHref = myHref + '/'; // Append a slash to it. } if (path == myHref) { $(this).parents('li').last().addClass('active current-page'); $(this).parent('li').addClass('active current-page'); } }); $('#modalTags').on('tagAdded', function () { var oldCount = parseInt($('#litCommunityTagsCount').text()); $('#litCommunityTagsCount').text(oldCount + 1); }).on('tagRemoved', function () { var oldCount = parseInt($('#litCommunityTagsCount').text()); $('#litCommunityTagsCount').text(oldCount - 1); }); var isImpersonating = false; }); //var btn = $.fn.button.noConflict(); // reverts $.fn.button to jqueryui btn //$.fn.btn = btn; // assigns bootstrap button functionality to $.fn.btn </script> </body> </html>