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“Definitions, End Points, and Clinical Trial Designs for Bladder Cancer: Recommendations From the Society for Immunotherapy of Cancer and the International Bladder Cancer Group,” in the Journal of Clinical Oncology." /></head> <body class="bodyBackground bladder-cancer-trial-design interior "> <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-M6VQVS2" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div id="MPOuterMost" class="container full"> <form method="post" action="./bladder-cancer-trial-design" onsubmit="javascript:return WebForm_OnSubmit();" id="MasterPageForm" class="form"> <div class="aspNetHidden"> <input type="hidden" name="ScriptManager1_TSM" id="ScriptManager1_TSM" value="" /> <input type="hidden" name="StyleSheetManager1_TSSM" id="StyleSheetManager1_TSSM" value="" /> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input 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SITC Blog</a></li></ul></li></li></ul> </ul> </div> </div> </div> </nav> </div> <div class="MenuBarUnderline"> </div> </div> </div> </div> </div> <div id="MPOuter" class="row siteFrame "> <div id="ContentColumn" class="col-md-12">  <div id="BreadCrumb" class="BreadCrumb"> </div> <div id="MPContentArea" class="MPContentArea no-pageTitle-padding" role="main"> <h1 id="PageTitleH1" qa-attribute="PageTitleH1" style="display: none;" aria-hidden="true"> Definitions, End Points, and Clinical Trial Designs for Bladder Cancer </h1> <input type="hidden" name="ctl00$DefaultMasterHdnCommunityKey" id="DefaultMasterHdnCommunityKey" value="00000000-0000-0000-0000-000000000000" /> <div id="FlashMessageContainer"> </div> <div id="MainCopy_ContentWrapper"> <div class="row row-full ibcg-banner-bg "><div class="col-md-12" ><div class="row row-wide clearfix banner-container "><div class="col-md-8 section1"><div class="ContentItemHtml"><div class="HtmlContent"><h1 style="font-size: 22pt; line-height: 1.2em;"><strong>Definitions, End Points, and Clinical Trial Designs for Bladder Cancer: </strong>Recommendations from the Society for Immunotherapy of Cancer & the International Bladder Cancer Group</h1></div><div class="HtmlFooter"></div></div></div><div class="col-md-4 section2"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section3"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-8 section4"><div class="ContentItemHtml"> <div class="HtmlContent"><p>On behalf of the Society for Immunotherapy of Cancer (SITC) and the International Bladder Cancer Group (IBCG), we are pleased to announce the publication of the “<a href="https://doi.org/10.1200/jco.23.00307">Definitions, End Points, and Clinical Trial Designs for Bladder Cancer: Recommendations From the Society for Immunotherapy of Cancer and the International Bladder Cancer Group</a>,” in the <em>Journal of Clinical Oncology</em>. These recommendations provide a detailed clinical trial design guide to maximize the chance of capturing the benefit of medical therapies for each unique stage of bladder cancer, from low-risk non-muscle invasive bladder cancer (NMIBC) to metastatic disease.</p> <p>SITC and IBCG formed a partnership to develop Expert Panel recommendations in response to a significant unmet need that still exists for standardized trials designed for new urothelial carcinoma (UC) treatments specific to stage and treatment approach. In this new manuscript, the Expert Panel discusses standardization of key clinical design elements to identify optimal treatment options and improve outcomes for patients. By providing standardized criteria, the paper also aims to benefit the field by allowing cancer researchers to develop more comparable and robust data sets for meta-analyses. </p></div><div class="HtmlFooter"></div></div></div><div class="col-md-4 section5"><div class="ContentItemHtml gray-card"> <div class="HtmlContent"><p><strong>Key Bladder Cancer Stage-Specific Recommendations:</strong></p> <ul> <li style="margin-bottom: .5em;">Rationally selected endpoints</li> <li style="margin-bottom: .5em;">Eligibility criteria</li> <li style="margin-bottom: .5em;">Response measurement</li> <li style="margin-bottom: .5em;">Statistical analyses (including minimal value for effect and sample size considerations)</li> <li style="margin-bottom: .5em;">Pathology considerations </li> </ul></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section6"></div></div><div class="row row-wide clearfix "><div class="col-md-12 section7"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><strong>Companion Education </strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section8"><div class="ContentItemHtml"><div class="HtmlContent"><p>To help provide a deeper understanding of the recommendations, SITC hosted a <a href="https://sitc.execinc.com/edibo/IBCG2024" target="_blank" rel="noopener">webinar</a> on March 18, 2024, from 4–5 p.m. CST with the manuscript authors serving as faculty for the program. Participants joined experts to discuss the publication in-depth, ask questions and explore topics such as: non-muscle and muscle invasive bladder cancer, metastatic unresectable and locally advanced disease.</p></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section9"><div class="ContentItemHtml accordion-heading container"> <div class="HtmlContent"><h3>Moderators</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"> <div class="HtmlContent"><ul> <li style="margin-bottom: .5em;"><strong>Matthew D. Galsky, MD</strong> – <em>Mount Sinai</em></li> <li><strong>Ashish Kamat, MD, MBBS</strong> - <em>University of Texas MD Anderson Cancer</em><br><em>Center</em></li> </ul></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"> <div class="HtmlContent"><h3>Faculty Speakers</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"> <div class="HtmlContent"><ul> <li style="margin-bottom: .5em;"><strong>Andrea Apolo MD</strong> — <em>National Cancer Institute/Center for Cancer Research</em></li> <li style="margin-bottom: .5em;"><strong>Shilpa Gupta, MD</strong><em> — Cleveland Clinic Taussig Cancer Institute</em></li> <li style="margin-bottom: .5em;"><strong>Seth Lerner, MD, FACS</strong> — <em>Baylor College of Medicine</em></li> <li style="margin-bottom: .5em;"><strong>Sarah P. Psutka</strong><em> — University of Washington</em></li> </ul></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"> <div class="HtmlContent"><h3>Learning Objectives</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"> <div class="HtmlContent"><ol> <li style="margin-bottom: .5em;">Understand appropriate definitions and end points that are relevant to the understanding of existing trials in each unique stage of bladder cancer, from low-risk non-muscle invasive bladder cancer (NMIBC) to metastatic disease.</li> <li style="margin-bottom: .5em;">Understand nuances of rationally selected endpoints, eligibility criteria, response measurement, statistical analyses (including minimal value for effect and sample size considerations), and pathology considerations</li> <li style="margin-bottom: .5em;">Apply these key clinical design elements and standardized criteria to their clinical trials (and practice) to identify optimal treatment options and improve outcomes for patients.</li> <li>Apply these criteria to develop comparable and robust data sets for meta-analyses. </li> </ol></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section10"></div><div class="col-md-6 section11"></div></div><div class="row row-wide clearfix "><div class="col-md-12 section12"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section13"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-8 section14"><div class="ContentItemHtml"> <div class="HtmlContent"><p><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Bladder_Cancer/SITC-IBCG_Promo_Fig_-_Final.png" alt="SITC-IBCG Promo Fig - Final.png" data-mce-hlimagekey="e92a7900-63df-4ca1-8b97-86192e6cd3fe" data-mce-hlselector="#TinyMceContent_84e902ef-1fad-2294-7f9f-b8457c8a8eb7-tinyMceHtml" class="img-responsive" style="width: 75%: margin: auto;"></p></div><div class="HtmlFooter"></div></div></div><div class="col-md-4 section15"><div class="ContentItemHtml"> <div class="HtmlContent"><p><a href="https://ascopubs.org/doi/10.1200/JCO.23.00307" target="_blank" rel="noopener"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Bladder_Cancer/Tweet_1_graphic_alt_-_front_page_publication.png" class="img-responsive" alt="Tweet 1 graphic alt - front page publication" data-mce-hlimagekey="2b2f57be-0e5c-117e-3eac-23c5814b858f" data-mce-hlselector="#TinyMceContent_9a30529a-b443-e00b-aa5a-4c0f95213713-tinyMceHtml"></a></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section16"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-full horizontal bg-grey "><div class="col-md-12" ><div class="row row-wide clearfix "><div class="col-md-12 section17"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 35px;"></div></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><h2><a id="authors" target="_blank"></a><strong>SITC-IBCG Bladder Cancer Clinical Trial Design Expert Panel</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section18"><div class="ContentItemHtml"> <div class="HtmlContent"><h3>CHAIR</h3> <p><strong>Matthew D. Galsky, MD </strong><br><em>Mount Sinai Medical Center</em></p></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section19"><div class="ContentItemHtml"> <div class="HtmlContent"><h3>CHAIR</h3> <p><strong>Ashish M. Kamat, MD, MBBS, FACS</strong><br><em>The University of Texas MD Anderson Cancer Center</em></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section20"></div></div><div class="row row-wide clearfix "><div class="col-md-12 section21"><div class="ContentItemHtml"> <div class="HtmlContent"><h3>Members</h3></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section22"><div class="ContentItemHtml"> <div class="HtmlContent"><p>Andrea B. Apolo, MD — <em>National Cancer Institute/Center for Cancer Research</em></p> <p>Marek Babjuk, MD, PhD — <em>Charles University, Praha</em></p> <p>Trinity J. Bivalacqua, MD, PhD — <em>University of Pennsylvania </em></p> <p>Peter Black, MD, FACS, FRCSC — <em>University of British Columbia</em></p> <p>Roger Buckley, MD, FRCSC — <em>North York General Hospital</em></p> <p>Matthew T. Campbell, MD, MS — <em>The University of Texas MD Anderson Cancer Center</em></p> <p>Eva Comperat, MD, PhD — <em>Sorbonne University</em></p> <p>Jason Efstathiou, MD, PhD, DPHIL — <em>Massachusetts General Hospital</em><em><br></em></p> <p>Petros Grivas, MD, PhD — <em>University of Washington</em></p> <p>Shilpa Gupta, MD — <em>Cleveland Clinic Taussig Cancer Institute</em></p> <p>Neil J. Kurtz, MD — <em>BCAN Representative</em></p></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section23"><div class="ContentItemHtml"> <div class="HtmlContent"><p>Donald Lamm, MD, FACS — <em>BCG Oncology, AZ</em></p> <p>Seth P. Lerner, MD, FACS — <em>Baylor College of Medicine</em></p> <p>Roger Li , MD — <em>H Lee Moffitt Cancer Center</em></p> <p>David J. 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