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Chemistry</span></a> </div> <div class="hexgrid__item"><a href="https://symeres.com/services/drug-development/" class="hexgrid__hex"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-drugdevelopment"></use></svg> <span>Drug Development</span></a> </div> <div class="hexgrid__item"><a href="https://symeres.com/services/admescope-adme-tox/" class="hexgrid__hex"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-admetox"></use></svg> <span>Admescope ADME-Tox</span></a> </div> </div> <div class="home-services__text"> <p>We are the leading transatlantic small molecule contract research and manufacturing organization that has been a trusted global partner for biotech and pharma companies for over 30 years.</p> </div> </div> </section> <section class="block block--primary"> <div class="block__content block__content"> <div class="block__text "> <h2><span class="ez-toc-section" id="About_us"></span>About us<span class="ez-toc-section-end"></span></h2> <div id="panel-gb2-647881605ddca-2-1-2" class="so-panel widget widget_sow-editor" data-index="5"> <div class="intro-text animate-6478816064619705805682 panels-animation-hide panel-widget-style panel-widget-style-for-gb2-647881605ddca-2-1-2" data-so-animation="{"selector":".animate-6478816064619705805682","animation":"fadeInRight","breakpoint":"780px","duration":1,"repeat":0,"hide":1,"disableAnimationMobile":0,"finalState":"visible","delay":0,"debounce":0,"event":"enter","offset":0}"> <div class="so-widget-sow-editor so-widget-sow-editor-base"> <div class="siteorigin-widget-tinymce textwidget"> <p>Symeres is the leading mid-sized transatlantic Contract Research Organization for your drug discovery and development challenges.</p> <p>With over 600 highly educated scientists in six locations in Europe and two in the USA, we offer best-in-class solutions for drug discovery and drug development, from small to medium-sized molecule hits. We are large enough to matter, and small enough to care.</p> <p>Our services span across early stage hit finding all the way to the delivery of your early clinical drug substance API. <strong>Making Molecules Matter. Together.</strong></p> </div> </div> </div> </div> <p><a href="https://symeres.com/about-us/" target="_self" class="button button--font">Read more</a></p> </div> <figure class="block__figure block__figure--bottom"> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/About-Symeres.png" alt=""> </figure> </div> </section> <section class="bgimg background-image-block" style="background-image:url('https://symeres.com/wp-content/uploads/2023/02/home-bgimg.jpg');"></section> <section class="block block--secondary"> <div class="block__content block__content--right"> <div class="block__text "> <h2><span class="ez-toc-section" id="Why_work_with_us"></span>Why work with us?<span class="ez-toc-section-end"></span></h2> <div id="panel-gb2-647881605ddca-3-0-0" class="so-panel widget widget_sow-editor panel-first-child" data-index="8"> <div class="xms-numbered-list white intro-text panel-widget-style panel-widget-style-for-gb2-647881605ddca-3-0-0"> <div class="so-widget-sow-editor so-widget-sow-editor-base"> <div class="siteorigin-widget-tinymce textwidget"> <p>Symeres offers a range of services in the fields of integrated drug discovery and development, from early hit synthesis to GMP manufacturing, via medicinal chemistry, <em>in vitro</em> pharmacology assays, ADME-Tox and PK via our Admescope platform, process research and development and supporting early formulation and solid-state chemistry. All underpinned by consolidated experience in the custom synthesis services.</p> <ul> <li>World-class expertise in innovative drug discovery, drug development and synthetic organic chemistry</li> <li>>30 years track record of successful project progression for our clients</li> <li>High staff retention means highly experienced teams</li> <li>Creative and adaptive problem-solving</li> <li>Excellence in communication</li> <li>Trusted partner network for additional platforms</li> <li>Laboratories in Europe and United States</li> </ul> </div> </div> </div> </div> </div> <figure class="block__figure block__figure--stretch"> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/02/home-work-image.png" alt="Work"> </figure> </div> </section> <section class="home-vacancies vacancies-block"> <div class="home-vacancies__content"> <div class="home-vacancies__text"> <h2><span class="ez-toc-section" id="Vacancies"></span>Vacancies<span class="ez-toc-section-end"></span></h2> <p>A career at Symeres is unlike any other. Groundbreaking research, inspiring clients, motivating projects and being part of talented teams. So if you’re an outstanding talent with a need to discover the solutions to all kinds of fascinating challenges, we want to hear from you.</p> </p> <p><a href="https://symeres.com/vacancies" target="_self" class="button button--secondary">View our vacancies</a></p> </div> <figure class="home-vacancies__figure"> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/02/home-vacancies-image.png" alt=""> </figure> <div class="home-vacancies__arrow"></div> <!-- <svg class="home-vacancies__arrow" aria-hidden="true"><use xlink:href="#icon-vacancies-arrow"></use></svg> --> </div> </section> <section class="home-news news-block"> <div class="home-news__content"> <h2><span class="ez-toc-section" id="Latest_news"></span>Latest news<span class="ez-toc-section-end"></span></h2> <p>Below are a few of our most recent news items.</p> <ul> <li> <a href="https://symeres.com/official-opening-of-new-oncolines-home-the-marie-curie-building-at-the-pivot-park-in-oss/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/09/news-Pivot-park-Curie_2.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Official opening of new Oncolines home, the Marie Curie Building at the Pivot Park in Oss, The Netherlands</p> <p>After months of dedication and collaboration, the official opening of the Marie Curie building at the Pivot Park in Oss was opened on Sep 19th, 2024. The Marie Curie building is a multitenant laboratory building which houses Oncolines B.V., the in vitro biology services laboratory of Symeres. Read more about this exciting development!</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/j-med-chem-publication-preclinical-lead-optimization-of-a-124-triazole-based-tankyrase-inhibitor/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/06/Template-Hexagon-Tankyrase.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">J. Med. Chem. Publication: Preclinical Lead Optimization of a 1,2,4-Triazole-Based Tankyrase Inhibitor</p> <p>In collaboration with Oslo University Hospital, we report the synthesis and biological activity of novel 1,2,3-triazole-based tankyrase inhibitors. Through a modular synthetic pathway and X-ray crystallography supported SAR analysis, we synthesized a series of novel TNKS inhibitors with improved ADME profiles, exhibiting antiproliferative efficacy in colorectal cancer cell lines. Click on the link below for a short summary of this publication.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/new-video-of-our-solid-state-center-of-excellence/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/Solid-State-video_website-image-1.jpg" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">New video of our Solid-State Center of Excellence</p> <p>In this new video our colleagues Gabriella Pizutti, Chantalle van Berkel, and Eva Verhofstad, will give you an exciting lab tour through the Symeres Solid-State Centre of Excellence, located at the Symeres site in Weert, the Netherlands. You will learn more about PhysChem Properties, Solid Form Screening, Crystallization, Crystal Habit, Pre-formulation, and Formulation. Feel free to contact us via the contact form on this website if you would like to learn more about our Solid-State capabilities.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/marina-virgili-about-barcelona-and-groningen/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/Marina-Virgilli.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Marina Virgili about Barcelona and Groningen</p> <p>We had the pleasure of sitting down with Marina Virgili, a dynamic and accomplished professional with a fascinating history in the pharmaceutical industry. Originally from the beautiful city of Barcelona, Marina shared insights into her background, career, and the unique experiences she has encountered along the way.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/new-equipment-at-exemplify/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/Exemply-New-Equipment-EasyMax.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">New equipment at Exemplify</p> <p>Exemplify has recently acquired a Mettler-Toledo EasyMax 402 automated reactor system to add to its process development capabilities. This instrument can accommodate reactor sizes of 100 and 400 mL and allows for the precise automated control of reaction parameters such as temperature, stirring speed, reagent addition rate, and pH, providing real-time data collection that can greatly enhance our understanding of a reaction’s unique profile. </p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/new-100-l-vessels-in-groningen/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/100-L-reactor_Featured.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">New 100 L vessels in Groningen</p> <p>The first of the two new 100 L glass-lined stainless steel reactor lines has successfully finished the testing and now it is operational at our Groningen site. By doubling our batch size capacity, we have increased the efficiency for large-scale non-GMP production projects. This will result in faster delivery times for our clients and less batch routine work for our chemists. </p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/rory-curtis-joins-symeres-business-development-team/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/Rory-Curtis-Symeres.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Rory Curtis joins Symeres Business Development Team</p> <p>We are happy to have such an experienced biologist on board to work with our many American clients. In this interview, our new colleague, Rory Curtis, will introduce himself and talk about the journey that led him from London to the city of Buffalo in New York state.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/symeres-ceo-eelco-ebbers-speaks-on-leaders-in-life-sciences-podcast/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/Podcast-icon-Leaders-in-life-science.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Symeres CEO Eelco Ebbers Speaks on “Leaders in Life Sciences” Podcast</p> <p>Symeres CEO Eelco Ebbers recently shared his insights on the renowned “Leaders in Life Sciences” podcast, hosted by Henk Jan Out. Recorded at the Pivot Park in Oss, near our subsidiary Oncolines, the interview delved into various facets of Eelco’s journey, including his educational background in organic chemistry, Symeres’ services and strategy, as well as personal interests such as family and hobbies. </p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/organix-new-facility/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/04/Organix-new-Facility.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Organix: New facility</p> <p>On March 26th we had the Grand Opening of our brand new, state-of-the-art Organix synthetic and analytical chemistry laboratories in Woburn, just outside Boston MA.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/towards-multitargeted-ligands-as-pain-therapeutics-dual-ligands-of-the-cav%ce%b12%ce%b4-1-subunit-of-voltage-gated-calcium-channel-and-the-%ce%bc-opioid-receptor/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/03/Dual-Ligands.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Towards Multitargeted Ligands as Pain Therapeutics: Dual Ligands of the Cavα2δ-1 Subunit of Voltage-Gated Calcium Channel and the μ-Opioid Receptor</p> <p>In collaboration with WeLab Barcelona, we report the synthesis and biological activity of novel pain therapeutics, which target both Cavα2δ-1 and MOR. One of these disubstituted pyrrolidines demonstrated an analgesic effect in various rodent models of pain, and a lack of unfavorable off-target interactions, showing no evident signs of withdrawal or tolerance. Click on the link below for a short summary of this publication.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/innovative-macrocycles-as-powerful-mcl-1-inhibitors/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/03/Mcl-1-Inhibitors-article_Image_2.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Innovative macrocycles as powerful Mcl-1 inhibitors</p> <p>This is a recap of the article “Development of potent Mcl-1 inhibitors: structural investigations on macrocycles originating from a DNA-encoded chemical library screen” published in the Journal of Medicinal Chemistry. Myeloid cell leukemia 1 (Mcl-1) is a protein that plays a crucial role in the regulation of cell survival and cell death. It is part of a family of proteins called the Bcl-2 family, which are known for their involvement in controlling the life span of cells.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/news-oncolines-unveiles-state-of-the-art-labotaries/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/02/Oncolines_hexagon2.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Oncolines unveils new State-of-the-Art Laboratories</p> <p>In a significant stride towards advancing cancer research and drug development, Oncolines, has officially received the keys to its new laboratories and offices situated within the prestigious Curie Building on the Pivot Park in Oss, the Netherlands.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/symeres-news-our-article-published-in-the-journal-of-medicinal-chemistry/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/02/Journal-medicinal-Chemistry.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Our Article Published in the Journal of Medicinal Chemistry</p> <p>Symeres is thrilled to announce the publication of a scientific article in the prestigious Journal of Medicinal Chemistry with our colleague Koen Hekking as the main author and many more Symerians involved! We are incredibly proud of our colleagues who were instrumental in the research and development of this innovative project.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/news-peter-molenveld-assumes-role-as-secretary-of-kncv-royal-netherlands-chemical-society/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/01/Peter-Molenveld-Symeres-–-5.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Peter Molenveld Assumes Role as Secretary of KNCV (Royal Netherlands Chemical Society)</p> <p>Symeres is proud to announce that our colleague Dr. Peter Molenveld has been appointed as a board member of the Royal Netherlands Chemical Society (KNCV). His appointment as Secretary marks a crucial milestone in Molenveld’s career and signifies his commitment to advancing the interests of the chemical community in the Netherlands.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/luc-van-hijfte-assumes-presidency-of-efmc-spearheading-advances-in-medicinal-chemistry-and-chemical-biology/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/01/Luc_van-Hijfte.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Luc van Hijfte Assumes Presidency of EFMC, Spearheading Advances in Medicinal Chemistry and Chemical Biology</p> <p>Symeres is thrilled to announce that as of January 1, 2024, our sr. Vice President Dr. Luc van Hijfte has taken the helm as the President of the European Federation of Medicinal Chemistry and Chemical Biology (EFMC). </p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/interview-with-the-computer-aided-drug-design-cadd-department/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/02/CADD-hexagon.png" alt="Computer Aided Drug Design at Symeres"> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Interview with the Computer-Aided Drug Design (CADD) Department</p> <p>Our Computer Aided Drug Design department supports our clients’ drug discovery projects with some of the best (predictive) software.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/news-clientcase-pinotbio/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/Pinotbio-image.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">“If the compound can be made, Symeres will undoubtedly find out a good way to make it.” Dooyoung Jung, CEO of Pinotbio.</p> <p>An in-depth interview with Doo Young Jung, the founder and CEO of our client Pinotbio in South Korea, focused on the challenge of cancer resistance/relapse</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/new-scientific-services-from-symeres/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/Services.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">New scientific services from Symeres</p> <p>We’re proud to announce that our brand new CMC facility at the Exemplify site of Symeres in New Jersey has been successfully completed. GMP drug product R&D facilities that will allow it to provide end-to-end services ranging from GMP and non-GMP drug product development to phase 1 and 2 clinical supplies of various oral, parenteral, and topical formulation dosage forms.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/interview-with-the-new-managing-director-of-symeres-groningen/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/Melloney-Droge-Symeres-Groningen_TN.jpg-.jpg" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Interview with the new Managing Director of Symeres Groningen</p> <p>On October 2, Dr Melloney Dröge started in her new role as Managing Director for the Groningen site.</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/chiral-chemistry-in-the-dna-of-symeres/" class="home-news__link"> <div class="home-news__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2023/11/Chiral-Chemistry-TN.png" alt=""> </figure> </div> <div class="home-news__text"> <p class="home-news__title">Chiral Chemistry: in the DNA of Symeres</p> <p>Over 50% of current drugs in development are chiral. At Symeres we apply a suite of state-of-the-art technologies to obtain the desired chiral compound in high enantiomeric purity. For decades, Symeres has been supporting the global pharma and biotech industry with the synthesis and delivery of chiral compounds, both through synthesis and purification strategies.</p> <p><strong>Read more</strong></p> </div> </a> </li> </ul> <p class="home-news__more"><a href="https://symeres.com/whats-new/news/" class="button">Read more articles</a></p> </div> </section> <section class="home-events events-block"> <div class="home-events__content"> <h2><span class="ez-toc-section" id="Latest_events"></span>Latest events<span class="ez-toc-section-end"></span></h2> <p>Symeres actively participates in many international Life Sciences conferences. See below for some of the upcoming events where you can meet us and discuss your R&D services needs.</p> <ul> <li> <a href="https://symeres.com/about-us/upcoming-events/" class="home-events__link"> <div class="home-events__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/09/AACR-KCA-ws.png" alt=""> </figure> </div> <div class="home-events__text"> <p class="home-events__title">2024 AACR-KCA Joint Conference on Precision Medicine in Cancer</p> <p><span>21-22 November</span><br>Seoul, Korea</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/about-us/upcoming-events/" class="home-events__link"> <div class="home-events__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/11/Biofit-2024-website-image.jpg" alt=""> </figure> </div> <div class="home-events__text"> <p class="home-events__title">BioFit 2024</p> <p><span>3-4 Dec</span><br>Lille, France</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/about-us/upcoming-events/" class="home-events__link"> <div class="home-events__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/11/Genesis-2024-website-image.jpg" alt=""> </figure> </div> <div class="home-events__text"> <p class="home-events__title">Genesis 2024</p> <p><span>4 Dec</span><br>London, UK</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/about-us/upcoming-events/" class="home-events__link"> <div class="home-events__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/11/bos-manchester-event-final.jpg" alt=""> </figure> </div> <div class="home-events__text"> <p class="home-events__title">SMR First Disclosures 2024</p> <p><span>Dec 5</span><br>London, UK</p> <p><strong>Read more</strong></p> </div> </a> </li> <li> <a href="https://symeres.com/about-us/upcoming-events/" class="home-events__link"> <div class="home-events__figure"> <figure> <img decoding="async" src="https://symeres.com/wp-content/uploads/2024/11/Dutch-Life-Science-Days-2024-website-event-image.jpg" alt=""> </figure> </div> <div class="home-events__text"> <p class="home-events__title">Dutch Life Sciences Conference 2024</p> <p><span>12 Dec</span><br>Leiden, Netherlands </p> <p><strong>Read more</strong></p> </div> </a> </li> </ul> <p class="home-events__more"><a href="https://symeres.com/about-us/upcoming-events/" class="button">More events</a></p> </div> </section> <section class="block block"> <div class="block__content block__content--right"> <div class="block__text"> <h2><span class="ez-toc-section" id="Feel_free_to_contact_us"></span>Feel free to contact us!<span class="ez-toc-section-end"></span></h2> <p><strong>Curious to know more about what can we do for you? 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src="//js-eu1.hs-scripts.com/25214463.js"></script> <!-- End of HubSpot Embed Code --> </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://symeres.com/wp-admin/admin-ajax.php" method="POST" id="actualsymeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="first-name">First name</label> <input id="first-name" name="first-name" type="text" placeholder="First name" required> </div> <div class="form__col"> <label for="last-name">Last name</label> <input id="last-name" name="last-name" type="text" placeholder="Last name" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="company">Company</label> <input id="company" name="company" type="text" placeholder="Company" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="email">Corporate email</label> <input id="email" name="email" type="email" placeholder="Corporate email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#actualsymeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#actualsymeresdownloads'); var email = $("#actualsymeresdownloads :input[name='email']").val(); var firstName = $("#actualsymeresdownloads :input[name='first-name']").val(); var lastName = $("#actualsymeresdownloads :input[name='last-name']").val(); var company = $("#actualsymeresdownloads :input[name='company']").val(); var action = $("#actualsymeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#actualsymeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#actualsymeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); </script><script id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { return; } // Get the skip-link target's ID, and generate one if it doesn't exist. skipLinkTargetID = skipLinkTarget.id; if ( ! skipLinkTargetID ) { skipLinkTargetID = 'wp--skip-link--target'; skipLinkTarget.id = skipLinkTargetID; } // Create the skip link. skipLink = document.createElement( 'a' ); skipLink.classList.add( 'skip-link', 'screen-reader-text' ); skipLink.href = '#' + skipLinkTargetID; skipLink.innerHTML = 'Skip to content'; // 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