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id="searchright" type="search" name="s" placeholder="Search"> <label class="search__button" for="searchright"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Search icon</title> <use xlink:href="#icon-search"></use> </svg> </label> </form> </div>       </div> </div> </header> <div class="hero"> <div class="hero__top" style="background-image: url('https://symeres.com/wp-content/uploads/2023/03/header-development-5_s.jpg');"> <div class="hero__content"> <div class="hero__heading"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-drugdevelopment"></use></svg> <h1>Drug Development</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#An_experienced_team_to_take_your_route_to_the_next_level" title="An experienced team to take your route to the next level.">An experienced team to take your route to the next level.</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Developability_Roadmap" title="Developability Roadmap">Developability Roadmap</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#Process_Research_and_Development" title="Process Research and Development">Process Research and Development</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-4" href="#Non-GMP_scale-up_for_IND-enabling_studies" title="Non-GMP scale-up for IND-enabling studies">Non-GMP scale-up for IND-enabling studies</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-5" href="#GMP_Manufacturing" title="GMP Manufacturing">GMP Manufacturing</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-6" href="#GMP_Starting_Materials" title="GMP Starting Materials">GMP Starting Materials</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-7" href="#Solid-State_Chemistry_and_Pre-Formulation_Research" title="Solid-State Chemistry and Pre-Formulation Research">Solid-State Chemistry and Pre-Formulation Research</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-8" href="#Watch_the_new_video_of_our_Solid-State_Center_of_Excellence" title="Watch the new video of our Solid-State Center of Excellence:">Watch the new video of our Solid-State Center of Excellence:</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-9" href="#Formulation_Development_and_Clinical_Manufacturing" title="Formulation Development and Clinical Manufacturing">Formulation Development and Clinical Manufacturing</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-10" href="#Analytical_Development_Services" title="Analytical Development Services">Analytical Development Services</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-11" href="#ICH_Stability_Studies" title="ICH Stability Studies">ICH Stability Studies</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-12" href="#Quality_Unit" title="Quality Unit">Quality Unit</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-13" href="#EHS_Compliance" title="EHS Compliance">EHS Compliance</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <h2 class="wp-block-heading"><span class="ez-toc-section" id="An_experienced_team_to_take_your_route_to_the_next_level"></span><strong>An experienced team to take your route to the next level.</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>Make use of our 30 years’ experience and collective brainpower to design the optimal route towards your new drug. Furthermore, the process can seamlessly transition to our scale-up non-GMP or GMP units.</strong></p> <p class="has-medium-font-size">We offer an integrated approach to process development to achieve a comprehensive control strategy and ensure that the chemistry developed is readily and safely scalable in a manufacturing environment. Our development approach aims at delivering a manufacturing route that satisfies operational performance requirements and those of the regulatory authorities.</p> <p class="has-medium-font-size">With two separate non-GMP and cGMP supporting business units, key preclinical milestones can be reached quickly, without the GMP overhead. We ensure a seamless transition into our GMP operation for clinical API manufacturing. This is a highly efficient and cost-competitive model, whereby you can always count on an experienced support team with a dedicated project manager.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Developability_Roadmap"></span>Developability Roadmap<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong><a href="https://symeres.com/services/drug-discovery/">Drug discovery</a> and <a href="https://symeres.com/services/drug-development/">development</a> entail a multifaceted journey, from identification to market approval. Our proprietary Developability Roadmap package streamlines this process, providing a clear plan of evaluation and action for transitioning from discovery to development.</strong></p> <p class="has-medium-font-size">Comprising data from various technical disciplines, including <a href="https://symeres.com/services/synthetic-chemistry/">synthetic chemistry</a>, <a href="https://symeres.com/services/drug-development/#Solid_State_Chemistry_and_Pre-Formulation_Research">materials science</a>, <a href="https://www.exemplifybiopharma.com/">formulation</a>, <a href="https://symeres.com/services/admescope-adme-tox/">ADME</a>, and <a href="https://symeres.com/services/admescope-adme-tox/">toxicology</a>, our roadmap ensures comprehensive assessment and mitigation of potential issues or delays. With most studies being conducted in house and selected aspects being overseen by trusted third parties, we deliver a single, meticulously compiled document to facilitate your IND/IMPD filing.</p> <p class="has-medium-font-size">We provide insights backed up with data. Symeres collaborates with your team to identify risks, propose mitigation strategies, and coordinate future activities. By entrusting us with your Developability Roadmap, you save invaluable time and benefit from our industry experience and efficient project management.</p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="658" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201024%20658'%3E%3C/svg%3E" alt="" class="wp-image-6547" data-lazy-srcset="https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1024x658.jpg 1024w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-300x193.jpg 300w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-768x493.jpg 768w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1536x987.jpg 1536w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-2048x1316.jpg 2048w" data-lazy-sizes="(max-width: 1024px) 100vw, 1024px" data-lazy-src="https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1024x658.jpg" /><noscript><img decoding="async" width="1024" height="658" src="https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1024x658.jpg" alt="" class="wp-image-6547" srcset="https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1024x658.jpg 1024w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-300x193.jpg 300w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-768x493.jpg 768w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-1536x987.jpg 1536w, https://symeres.com/wp-content/uploads/2024/06/Roadmap-illustration_LI-2048x1316.jpg 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></noscript></figure> <p></p> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Process_Research_and_Development"></span><strong>Process Research and Development</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>We can help to mitigate CMC risk when transitioning from research to development.</strong></p> <figure class="wp-block-image alignright size-full"><img decoding="async" width="402" height="537" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20402%20537'%3E%3C/svg%3E" alt="" class="wp-image-3365" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/06/Process-research.png 402w, https://symeres.com/wp-content/uploads/2023/06/Process-research-225x300.png 225w" data-lazy-sizes="(max-width: 402px) 100vw, 402px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/06/Process-research.png" /><noscript><img decoding="async" width="402" height="537" src="https://symeres.com/wp-content/uploads/2023/06/Process-research.png" alt="" class="wp-image-3365" srcset="https://symeres.com/wp-content/uploads/2023/06/Process-research.png 402w, https://symeres.com/wp-content/uploads/2023/06/Process-research-225x300.png 225w" sizes="(max-width: 402px) 100vw, 402px" /></noscript></figure> <p class="has-medium-font-size">We offer route scouting, risk assessments, catalyst screens, and early safety studies. This is supported by parallel experimentation and design-of-experiment (DoE) optimization, to ensure that the route chosen for clinical supply will be robust, reliable, and scalable. Symeres has developed hundreds of novel routes for innovative APIs throughout the years.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Non-GMP_scale-up_for_IND-enabling_studies"></span>Non-GMP scale-up for IND-enabling studies<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>Symeres has long-established expertise in non-GMP scale-up for IND-enabling studies, ensuring that our clients can confidently navigate the transition from <a href="https://symeres.com/services/synthetic-chemistry/">laboratory-scale synthesis</a> to clinical phases while minimizing costs and risks. </strong></p> <p class="has-medium-font-size">The well-documented processes we provide significantly reduce the inherent risks associated with scaling up of production. Our team of experienced chemists specializes in process optimization, delivering efficient and effective non-GMP scale-up procedures. </p> <p class="has-medium-font-size">During non-GMP scale-up, we focus on a series of key parameters in the evolution from drug discovery to development, notably encompassing the development of the most suitable solid form, analytical packages, and batch records. Our systematic approach guarantees that impurity profiles are carefully monitored and controlled, mitigating potential regulatory concerns, and securing the safety of the final API. At this stage, time and budget are critical, and scale-up optimization necessitates adherence to a phase-appropriate strategy with quality and safety standards without compromise, a principle we consistently uphold.</p> <p class="has-medium-font-size">Non-GMP scale-up forms part of a bigger picture of IND-enabling activities, and at Symeres we can also build robust packages around <a href="https://symeres.com/services/drug-development/#Solid-State_Chemistry_and_Pre-Formulation_Research">solid-state chemistry</a>, <a href="https://www.exemplifybiopharma.com/">formulation</a>, and <a href="https://symeres.com/services/admescope-adme-tox/">ADME-Tox</a>. These can be combined in a tailored package as part of our developability roadmap.</p> <p class="has-medium-font-size">Our commitment to adhering to industry regulations and guidelines, coupled with our comprehensive documentation practices, provides clients with the confidence that their non-GMP scale-up activities will meet regulatory requirements and facilitate a smooth regulatory submission process and form the basis for subsequent <a href="https://symeres.com/services/drug-development/#GMP_Manufacturing">GMP manufacturing of drug substances</a> and <a href="https://www.exemplifybiopharma.com/">drug products</a>.</p> <p class="has-medium-font-size">By leveraging our expertise, clients can expedite the development timeline and accelerate progression to later clinical phases.<br><br></p> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="GMP_Manufacturing"></span>GMP Manufacturing<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>Close collaboration with our experienced process engineers aid our efforts achieve right first time scale-up of processes for GMP manufacture.</strong></p> <p class="has-medium-font-size">The processes developed at our facilities are adapted to the plant environment in close collaboration with experienced process engineers. The limits of operating conditions are tested and their effect on yield and purity evaluated to gain full control over critical process parameters (CPPs). The choice of chemistry applied, as well as of solvents and materials, aims to guarantee process and patient safety. Special attention is paid to possible formation and detection of potentially genotoxic impurities (PGIs). Our scientists combine their knowledge and expertise to develop a process that delivers the requested API with the desired critical quality attributes (CQAs), yield, and solid form. Our efforts aim to achieve right first time scale-up.</p> <p class="has-medium-font-size">Analysts, chemists, and solid-state experts work together to achieve a comprehensive control strategy and ensure that the processes developed are readily and safely scalable in a manufacturing environment.</p> <p class="has-medium-font-size">Analytical support is provided throughout the project life cycle from development to manufacturing. Robust project-specific analytical methods are developed and validated appropriately throughout the clinical phase of the project.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="GMP_Starting_Materials"></span>GMP Starting Materials<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>To deliver starting materials of the best quality and suitability for GMP manufacturing, Symeres is equipped with an experienced non-GMP scale-up lab.</strong></p> <p class="has-medium-font-size">Control over the quality and delivery of the starting materials is essential in GMP manufacturing. Symeres has a non-GMP scale-up lab experienced in the synthesis of regulatory starting materials. In our facilities, we can run reactions up to 50 L scale (four 50 L reactors (QVF, ChemGlass) and multiple 20 L reactors) and perform column chromatography on large scale (20 kg silica). </p> <figure class="wp-block-image size-full is-resized"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20336%20386'%3E%3C/svg%3E" alt="" class="wp-image-3371" width="336" height="386" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials.png 336w, https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials-261x300.png 261w" data-lazy-sizes="(max-width: 336px) 100vw, 336px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials.png" /><noscript><img decoding="async" src="https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials.png" alt="" class="wp-image-3371" width="336" height="386" srcset="https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials.png 336w, https://symeres.com/wp-content/uploads/2023/06/Logistics-starter-materials-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></noscript></figure> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Solid-State_Chemistry_and_Pre-Formulation_Research"></span>Solid-State Chemistry and Pre-Formulation Research<span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-full"><img decoding="async" width="336" height="386" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20336%20386'%3E%3C/svg%3E" alt="" class="wp-image-2324" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/05/druk-development-3.png 336w, https://symeres.com/wp-content/uploads/2023/05/druk-development-3-261x300.png 261w" data-lazy-sizes="(max-width: 336px) 100vw, 336px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/05/druk-development-3.png" /><noscript><img decoding="async" width="336" height="386" src="https://symeres.com/wp-content/uploads/2023/05/druk-development-3.png" alt="" class="wp-image-2324" srcset="https://symeres.com/wp-content/uploads/2023/05/druk-development-3.png 336w, https://symeres.com/wp-content/uploads/2023/05/druk-development-3-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></noscript></figure> <p class="has-medium-font-size"><strong>Our Solid-State experts can help you to selectively crystallize the optimal stable form and formulate your compound.</strong></p> <p class="has-medium-font-size">A controlled crystallization is the preferred isolation method to obtain purified material of a specific polymorphic (salt) form and crystal habit. The solid form determines the stability, solubility and permeability of the compound; therefore, the selection of a pharmaceutically suitable form will manage the risks in further development. The pre-formulation experts study excipient compatibility, pH-dependent solubility and dissolution rate optimization to improve the bioavailability. Symeres has performed hundreds of form characterization and selection screens on innovative APIs throughout the years. </p> <p class="has-medium-font-size">Read more about our <a href="https://symeres.com/expansion-of-solid-state-center-of-excellence/">Solid-State capabilities</a>.</p> <h6 class="wp-block-heading"><span class="ez-toc-section" id="Watch_the_new_video_of_our_Solid-State_Center_of_Excellence"></span>Watch the new video of our Solid-State Center of Excellence:<span class="ez-toc-section-end"></span></h6> <figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"><div class="wp-block-embed__wrapper"> <div class="rll-youtube-player" data-src="https://www.youtube.com/embed/x4DEQcetOkM" data-id="x4DEQcetOkM" data-query="feature=oembed" data-alt="Symeres Solid-State"></div><noscript><iframe title="Symeres Solid-State" width="500" height="281" src="https://www.youtube.com/embed/x4DEQcetOkM?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></noscript> </div></figure> <p></p> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Formulation_Development_and_Clinical_Manufacturing"></span><strong>Formulation Development and Clinical Manufacturing</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>We blend the art of formulation with advanced scientific tools to support drug product development from early stages through Phase 3, offering comprehensive manufacturing and regulatory services.</strong></p> <p class="has-medium-font-size">It is often said that formulation is an art, not a science. Our art is supported by an extensive array of scientific tools that allow us to design and deliver formulations across a wide range of modalities, including immediate release, delayed release, extended release, osmotic/pulsatile drug delivery, sprinkle formulation, solution/suspension, and topical formulation. We support projects from toxicology through Phase 3 and beyond, including tech transfer to your commercial site. We can also assist in troubleshooting commercial formulation problems.</p> <figure class="wp-block-image alignright size-full"><img decoding="async" width="402" height="537" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20402%20537'%3E%3C/svg%3E" alt="" class="wp-image-6720" data-lazy-srcset="https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing.png 402w, https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing-225x300.png 225w" data-lazy-sizes="(max-width: 402px) 100vw, 402px" data-lazy-src="https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing.png" /><noscript><img decoding="async" width="402" height="537" src="https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing.png" alt="" class="wp-image-6720" srcset="https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing.png 402w, https://symeres.com/wp-content/uploads/2024/08/Development-And-Clinical-manufacturing-225x300.png 225w" sizes="(max-width: 402px) 100vw, 402px" /></noscript></figure> <p class="has-medium-font-size">Our state-of-the-art analytical services encompass method development, verification, and transfer. With cutting-edge equipment such as the Xcelodose X600S for precision capsule filling, the ACG Quest FB II for fluid bed processing, and a range of analytical instruments including automated hardness testers, disintegration apparatus, and moisture analyzers, we ensure unparalleled precision and efficiency at every step of the formulation process.</p> <p class="has-medium-font-size">We offer IND enabling, preclinical formulation, solid-state characterization, clinical formulation development, ICH stability studies, dissolution method development, and GMP-compliant clinical manufacturing. Additionally, we provide consultancy and authoring, as well as the review of the CMC technical elements of regulatory dossiers. </p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Analytical_Development_Services"></span>Analytical Development Services <span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-large is-resized"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20395%20522'%3E%3C/svg%3E" alt="" class="wp-image-7089" width="395" height="522" data-lazy-srcset="https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-775x1024.jpg 775w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-227x300.jpg 227w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-768x1014.jpg 768w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-1163x1536.jpg 1163w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg.jpg 1398w" data-lazy-sizes="(max-width: 395px) 100vw, 395px" data-lazy-src="https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-775x1024.jpg" /><noscript><img decoding="async" src="https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-775x1024.jpg" alt="" class="wp-image-7089" width="395" height="522" srcset="https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-775x1024.jpg 775w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-227x300.jpg 227w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-768x1014.jpg 768w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg-1163x1536.jpg 1163w, https://symeres.com/wp-content/uploads/2024/11/analytical-services-image-symeres-final-jpeg.jpg 1398w" sizes="(max-width: 395px) 100vw, 395px" /></noscript></figure> <p class="has-medium-font-size">At Symeres, we offer comprehensive analytical development services, ensuring a deep understanding of product quality and stability throughout the drug development lifecycle. With expertise in chromatography, impurity profiling, and solid-state characterization, our GMP-compliant laboratories provide tailored solutions for every phase of drug development</p> <p class="has-medium-font-size">Our services include:</p> <ul class="wp-block-list"> <li class="has-medium-font-size">Method development, optimization, and validation in accordance with ICH guidelines.</li> <li class="has-medium-font-size">Impurity identification and control strategies, including genotoxic and nitrosamine impurities.</li> <li class="has-medium-font-size">Full analytical support for APIs and drug products, including (chiral) HPLC/UPLC, LC/MS, NMR, and more.</li> <li class="has-medium-font-size">Stability studies, dissolution testing, and quality control for regulatory submissions.</li> </ul> <p class="has-medium-font-size">We ensure data integrity through advanced informatics systems, offering seamless analytical data management and GMP sample handling. Our team delivers reliable, high-quality analytical packages to meet your drug development needs efficiently and effectively.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="ICH_Stability_Studies"></span>ICH Stability Studies<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>Symeres has the capability to perform stability studies in accordance with ICH guidelines.</strong></p> <p class="has-medium-font-size">We offer the possibility to perform long-term and accelerated stability studies under standard conditions (5°C, 40°C/75% RH, 30°C/65% RH, 25°C/60% RH), according to ICH Q1A guidelines. Selected batches are stored in the agreed packaging in our qualified stability chambers. Validated stability-indicating analytical methods are used to monitor variations of the relevant attributes.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Quality_Unit"></span>Quality Unit<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>Compliance with regulations forms the cornerstone of your project and we ensure quality at all stages of manufacture.</strong></p> <p class="has-medium-font-size">Our Weert (The Netherlands) and Prague (Czech Republic) facilities are <a href="https://symeres.com/renewal-of-the-gmp-certificate-for-symeres-prague/">GMP certified</a> and FDA inspected.</p> <p class="has-medium-font-size">Our Quality Management System (QMS) is in place to guarantee compliance to all required elements of GMP, such as those described in the ICH Q7 guidelines and Eudralex, Vol. 4.</p> <p class="has-medium-font-size">Our Quality Assurance (QA) and Quality Control (QC) departments are responsible for ensuring that all finished products are manufactured in accordance with relevant procedures, requirements, and specifications, in line with cGMP guidelines and client-specific quality agreements.</p> <p class="has-medium-font-size">Our employees are trained to develop a strong compliance mindset to guarantee product assurance and adherence to regulations. A mentality of continuous improvement is embedded in our organization.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="EHS_Compliance"></span>EHS Compliance<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>We evaluate all materials and projects entering Symeres facilities to minimize risks for all involved.</strong></p> <p class="has-medium-font-size">Our first priority is to guarantee the safety of patients, our employees, and the environment.</p> <figure class="wp-block-image alignleft size-full"><img decoding="async" width="336" height="386" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20336%20386'%3E%3C/svg%3E" alt="" class="wp-image-3367" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/06/EHS.png 336w, https://symeres.com/wp-content/uploads/2023/06/EHS-261x300.png 261w" data-lazy-sizes="(max-width: 336px) 100vw, 336px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/06/EHS.png" /><noscript><img decoding="async" width="336" height="386" src="https://symeres.com/wp-content/uploads/2023/06/EHS.png" alt="" class="wp-image-3367" srcset="https://symeres.com/wp-content/uploads/2023/06/EHS.png 336w, https://symeres.com/wp-content/uploads/2023/06/EHS-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></noscript></figure> <p class="has-medium-font-size">All incoming materials and projects are evaluated by our Environment, Health, and Safety (EHS) officers to determine if the material is suitable for our facilities and unit operations and which engineering controls and personal protection equipment (PPEs) are required to prevent exposure and (cross-)contamination.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? 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