Degraders and Molecular Glues - Part 1 | Discovery On Target

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data-sf-element="Column 1" data-placeholder-label="Column 1"> <div > <div class="sf-Long-text" ><h3>Cambridge Healthtech Institute’s 7th Annual</h3><h1>Degraders & Molecular Glues</h1><br /><h2>Part 1: Design and Optimization of Novel Degraders, Glues, and Conjugates</h2><h4>September 23-24, 2025</h4><h2>Part 2: New Targets, Ligases, Assays for Induced Proximity and Degradation</h2><h4>September 24-25, 2025</h4><p style="margin:0in;"> </p><p style="margin:0in;">Hetero bifunctional molecules like proteolysis-targeting chimeras (PROTACs), monovalent molecules like molecular glues, and other novel conjugates and modalities are utilizing the ubiquitin-proteasome, lysosome, and autophagy systems to seek out previously “undruggable” targets for therapeutic intervention. Cambridge Healthtech Institute’s two-part conference on Degraders and Molecular Glues brings together experts from industry and academia to discuss both induced proximity and targeted protein degradation as viable therapeutic approaches.</p><p style="margin:0in;"> </p><p style="margin:0in;"><b>Part 1:</b></p><p style="margin:0in;">Part 1 will discuss the design and optimization of new monovalent molecular glues and heterobifunctional degraders and conjugates. Challenges that exist in terms of specificity, stability, biodistribution, and penetration of these molecules for better <i>in vitro</i> to <i>in vivo</i> translation will be discussed.</p><p style="margin:0in;"><b> </b></p><p style="margin:0in;"><b>Coverage will include, but is not limited to:</b></p><p style="margin:0in;"><b> </b></p><ul type="disc" style="margin-bottom:0in;margin-top:0in;"><li style="margin:0in;">Design: synthesis of novel PROTACs, rational design of molecular glues and conjugates</li><li style="margin:0in;">Induced proximity: covalent strategies, tools, and rules for innovative linker design</li><li style="margin:0in;">Conjugates: ADC-PROTACs, peptide-PROTACs, aptamer functionalized PROTACs</li><li style="margin:0in;">AI/ML tools for designing degraders and predicting ternary complex formation</li><li style="margin:0in;">Structural characterization: new assays for structural and mechanistic studies</li><li style="margin:0in;">Optimization: ADME/DMPK, stability, biodistribution, oral availability</li><li style="margin:0in;">Tissue specificity: <i>in situ</i> activated PROTACs and other approaches</li><li style="margin:0in;">Advances in PROTAC Delivery: new formulations, nanocarriers</li><li style="margin:0in;">Safety concerns: <i>in vitro</i> to <i>in vivo</i> translation challenges</li></ul><p style="margin:0in 0in 0in 0.5in;"> </p><p style="margin:0in;"><b>Part 2:</b></p><p style="margin:0in;">Part 2 focuses on emerging assays and screening strategies for identifying new drug targets, ligases, and neosubstrates for induced proximity and targeted degradation.</p><p style="margin:0in;"><b> </b></p><p style="margin:0in;"><b>Coverage will include, but is not limited to:</b></p><p style="margin:0in;"><b> </b></p><ul type="disc" style="margin-bottom:0in;margin-top:0in;"><li style="margin:0in;">Undruggable targets: KRAS, extracellular targets, bacterial/viral targets, transcription factors membrane proteins, cell surface receptors </li><li style="margin:0in;">Novel ligases: targeting tissue specific ligases, assays for DCAF1, FOXO3, TRIM2, and other ligases</li><li style="margin:0in;">Going beyond E3 ligases for degradation; exploring ubiquitin editing</li><li style="margin:0in;">Exploring degraders and glues for non-oncology indications</li><li style="margin:0in;">Screening: proximity assays, chemoproteomics and AI/ML to identify novel ligases and targets</li><li style="margin:0in;">Finding new degradation pathways: Structural and mechanistic assays and techniques</li><li style="margin:0in;">PROTACs for combination therapy (enhance internalization of ADCs)</li></ul><p style="margin:0in;"> </p><p style="margin:0in;"><b>The deadline for priority consideration is March 7, 2025.</b></p><p style="margin:0in;"> </p><p style="margin:0in;"><i>All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.</i></p><p style="margin:0in;"> </p><p style="margin:0in;"><b>Opportunities for Participation:</b></p><p style="margin:0in 0in 0in 0.5in;"> </p><ul><li>To submit a <b>podium presentation</b>, please <a href="/speaker-proposal" data-sf-ec-immutable="">click here</a>. <p style="margin:0in;"> </p></li><li>To become a <b>sponsor</b>, <a href="/sponsorship-opportunities" data-sf-ec-immutable="">click here</a>. <p style="margin:0in 0in 0in 0.5in;"> </p></li><li>To present a <b>poster</b>, <a href="/posters" data-sf-ec-immutable="">click here</a>. <p style="margin:0in 0in 0in 0.5in;"> </p></li><li>To sign up to <b>attend</b>, <a href="https://register.healthtech.com/reg/dot" data-sf-ec-immutable="">click here</a>.</li></ul></div> </div> <div > <div 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href="/targeting-mash-obesity" data-sf-ec-immutable="">Targeting MASH & Obesity <span class="new">NEW</span> </a> <hr class="sidebar-rule" /><p class="sidebar-date">September 24-25</p><a href="/protacs-molecular-glues-part2" data-sf-ec-immutable="">Degraders & Molecular Glues – Part 2</a> <a href="/lead-generation-strategies" data-sf-ec-immutable="">Lead Generation Strategies</a> <a href="/cancer-antibodies" data-sf-ec-immutable="">Emerging Cancer Targets for Multispecifics, ADCs, and Biologics</a> <a href="/gpcr-drug-discovery" data-sf-ec-immutable="">GPCR-Based Drug Discovery</a> <a href="/targeting-transcription-factors" data-sf-ec-immutable="">Targeting Transcription Factors & Regulators</a> <a href="/ai-ml-enabled-drug-discovery-part2" data-sf-ec-immutable="">AI/ML-Enabled Drug Discovery - Part 2</a> </div> </div></div> </div> </div> </div> </div> </div> <footer> <div > <div class="sf-Long-text" ><div class="footer"><div class="container"><div class="row"><div class="col-sm-3 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Degraders and Molecular Glues - Part 1 | Discovery On Target | Sept 30 - Oct 3, 2024