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data-sf-element="Column 1" data-placeholder-label="Column 1"> <div > <div class="sf-Long-text" ><h1 class="page-title">2024 In-Person Breakouts</h1><p>In-Person Breakouts are informal, moderated discussions, allowing participants to exchange ideas and experiences and develop future collaborations around a focused topic. Each breakout will be led by a facilitator who keeps the discussion on track and the group engaged. To get the most out of this format, please come prepared to share examples from your work, be a part of a collective, problem-solving session, and participate in active idea sharing.</p><p>All Breakouts – including Wednesday’s Diversity Discussion – will be offered <b>IN-PERSON ONLY</b>.</p><br /><p class="Date">PART A CONFERENCES: TUESDAY, OCTOBER 1, 2:50-3:35 PM </p><p class="Session secondary-text pad-bottom dark-blue"><u>Degraders and Molecular Glues – Part 1</u></p><p class="Session terciary-text">BREAKOUT 1: Structural and Mechanistic Characterization of Degraders and Glues</p><p class="Speaker">Moderators:<br />Ralph Mazitschek, PhD, Assistant Professor, Harvard Medical School; Co-Director of the Chemical Biology Platform, Center for Systems Biology, Massachusetts General Hospital<br />Hua Xu, PhD, Director, Mechanistic Biology & Profiling, AstraZeneca</p><ul class="Abstract"><li><i>In vitro</i> characterization to develop new degrader/glue modalities</li><li>Developing assays that are sensitive and unbiased in finding the right targets and ligands</li><li>Overcoming limitations in current biochemical and cellular assays</li></ul><p class="Session terciary-text">BREAKOUT 2: Tackling Transcription Factors and Other Difficult-to-Drug Targets</p><p class="Speaker">Moderators:<br />John Brognard, PhD, Senior Investigator, Laboratory of Cellular & Developmental Signaling, National Cancer Institute, National Institutes of Health<br />Wankyu Lee, PhD, Senior Research Scientist, AstraZeneca Pharmaceuticals<br />Peng Wu, PhD, Professor, Chemical Physiology, Scripps Research Institute</p><ul class="Abstract"><li>When to classify a target as being challenging or difficult?</li><li>How to find tools and assays that will work with challenging targets?</li><li>Examples of how difficult targets are being pursued using new approaches and modalities</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Lead Generation Strategies</u></p><p class="Session terciary-text">BREAKOUT 3: Affinity Selection-Mass Spectrometry (AS-MS) for <i>de novo</i> Hit Generation and DEL Hit Verification</p><p class="Speaker">Moderators:<br />Allen Annis, PhD, Independent Consultant, former SVP Research, Aileron Therapeutics<br />Hans-Peter N. Biemann, PhD, Distinguished Scientist, Integrated Drug Discovery, Sanofi</p><ul class="Abstract"><li>AS-MS and DEL as synergistic tools for hit generation and verification of on- and off-DNA hit structures</li><li>Where does AS-MS fit in the HTS toolbox vs. DEL and other biophysical/biochemical screening technologies?</li><li>How do we access AS-MS for hit-finding and verification? Outsourcing options vs. in-house platform development</li></ul><p class="Session terciary-text">BREAKOUT 4: Hit Validation Strategies</p><p class="Speaker">Moderator: Mitchell H. Keylor, PhD, Associate Principal Scientist, Merck</p><ul class="Abstract"><li>Eliminating false positives</li><li>Data analysis formats</li><li>Binding methods: How important is it? Favorite biophysical tools?</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Small Molecules for Cancer Targets <font color="red">(3:05-3:35 pm)</font></u></p><p class="Session terciary-text">BREAKOUT 5: Covalent Approaches for Drug Discovery</p><p class="Speaker">Moderator: Paul E. Gormisky, PhD, Senior Director, Enabling Sciences Chemistry, Odyssey Therapeutics</p><ul class="Abstract"><li>Strategies to prioritize targets for covalent drug discovery</li><li>Assessing if a covalent ligand or fragment for a novel target can be progressed to a drug (e.g., sufficient pocket, supportive biology)</li><li>Role of covalency in other new modalities (degraders, macrocycles)</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Antibodies Against Membrane Protein Targets</u></p><p class="Session terciary-text">BREAKOUT 6: Avoiding Roadblocks: Maneuvering the Challenges of Difficult Targets</p><p class="Speaker">Moderator: Joseph Rucker, PhD, Vice President, Research and Development, Integral Molecular, Inc.</p><ul class="Abstract"><li>Antigen design: antigen strategies and engineering for optimal target presentation</li><li>Antibody sources: pros and cons of naive and immune libraries, and the benefits of using divergent species for targets that are highly conserved</li><li>Screening: best approaches to identify diverse antibody panels, and merits of B cell cloning vs. display technologies</li><li>Specificity: how to assess off-target binding</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Small Molecules Targeting RNA</u></p><p class="Session terciary-text">BREAKOUT 7: Challenges and Opportunities in Pursuing RNA as a Drug Target</p><p class="Speaker">Moderators: <br />Generoso Ianniciello, Chief Business Officer, Anima Biotech<br />Karthik Iyer, PhD, Director, Head of Medicinal Chemistry, Arrakis Therapeutics<br />Marla Weetall, PhD, Senior Vice President, Pharmacology and Biomarkers, PTC Therapeutics</p><ul class="Abstract"><li>Emerging techniques for probing and modulating RNA</li><li>Correlating RNA binding with function and physiological response</li><li>Designing and optimizing small molecules targeting various RNA moieties</li><li>Leveraging AI/ML, RNA degradation tools and other drug development strategies</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>AI/ML-Enabled Drug Discovery – Part 1</u></p><p class="Session terciary-text">BREAKOUT 8: How to Quantify Biology to Inform AI/ML-Driven Decisions in Drug Discovery</p><p class="Speaker">Moderators:<br />Arvind Rao, PhD, Associate Professor, Department of Computational Medicine and Bioinformatics, University of Michigan<br />Yuan Wang, PhD, Head of Research Analytics, UCB Pharma</p><ul class="Abstract"><li>Improving training sets and building better AI/ML models</li><li>Using deep learning, neural network analysis and imaging for drug discovery</li><li>Using large language models to help translational research and decision-making</li><li>Novel machine learning models for hit-finding and structure-activity predictions</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Physiologically Relevant Translational Models</u></p><p class="Session terciary-text">BREAKOUT 9: Standardization of Complex <i>in vitro</i> Models (CIVMs) in Drug Development</p><p class="Speaker">Moderators:<br />Linda Griffith, PhD, Professor, Biological Engineering & Teaching Innovation, Massachusetts Institute of Technology<br />James Hickman, PhD, Professor, NanoScience Technology Center, University of Central Florida<br />Stephanie Kourula, PhD, Principal Scientist, Johnson & Johnson Innovative Medicine<br />Lindsay Tomlinson, PhD, Global Pathologist Resource Lead, Pfizer Inc.</p><ul class="Abstract"><li>Opportunities and/or needs for standardization of <i>in vitro</i> models/microphysiological systems (MPS)</li><li>Ways to increase model utilization in the context of regulatory decision-making</li><li>Readiness of CIVM/MPS models for gaining acceptance in drug development</li><li>Drafting broadly applicable standards that can be applied regardless of context-of-use (COU) and/or organ system</li></ul><br /><p class="Date">PART B CONFERENCES: WEDNESDAY, OCTOBER 2, 5:15-6:15 PM </p><p class="Session secondary-text pad-bottom dark-blue" id="NaytiaByrd"><u>Diversity Discussion</u></p><p class="Session terciary-text">Fostering Diversity through Mentoring</p><p class="Speaker">Moderators:<br />Angelo Andres, Senior Scientist, Chemical Biology, AstraZeneca Pharmaceuticals<br />Carolyn Cuff, PhD, Head of Rheumatology, Translational Science, The Janssen Pharmaceutical Companies of Johnson & Johnson<br />Saudat Fadeyi, PhD, MBA, Director, Business Development, Ovid Therapeutics, Inc.<br />Minji Kim, PhD, MBA, Chief Business Officer, Mineralys Therapeutics, Inc. <br />Fred Manby, DPhil, Co-Founder & CTO, Iambic Therapeutics<br />Joel Omage, Research Scientist II, CVM Disease Area, Novartis Institutes for BioMedical Research, Inc.</p><p class="Abstract">Join us for this interactive, informal, candid discussion on embracing and increasing diversity in the life sciences. We have invited some engaging speakers to share their stories and experiences on understanding the importance of mentoring. How can we improve diversity—gender, racial, economic, and others—by being a mentor and reaching out as a mentee? As a group, we can share various initiatives that have been launched in different environments and discuss how well they have worked. We are hoping that this event will motivate the audience to learn, think, and execute on ways to improve diversity in their own environments. This discussion will not be recorded nor available for on-demand access.</p><p class="Session terciary-text">Topics for discussion will include, but certainly not be limited to:</p><ul class="Abstract"><li>How to increase awareness and address hidden barriers and biases in life sciences</li><li>How to motivate early-career scientists to seek out mentors and resources</li><li>How to convince senior leadership to take time for coaching the next generation of leaders and support DEI initiatives</li><li>How to create simple and impactful opportunities and metrics for mentors and mentees to connect and collaborate</li></ul><br /><p class="Date">PART B CONFERENCES: THURSDAY, OCTOBER 3, 10:20-11:05 AM </p><p class="Session secondary-text pad-bottom dark-blue"><u>Degraders and Molecular Glues – Part 2</u></p><p class="Session terciary-text">BREAKOUT 10: Novel Modalities, E3 Ligases and Ligands for Induced Proximity</p><p class="Speaker">Moderators:<br />Tauseef Butt, PhD, President & CEO, Progenra, Inc.<br />Rick Ewing, PhD, Vice President and Head of Chemistry, Rapafusyn Pharmaceuticals</p><ul class="Abstract"><li>Technologies enabling future induced proximity work</li><li>Improving potency, modularity and utility of degraders and glues</li><li>Discovery and validation of new degrader chemistries and functionality</li><li>Pursuing new E3 ligases and cellular pathways</li><li>Red Flags in PROTACs and Pink Flags in molecular glues</li></ul><p class="Session terciary-text">BREAKOUT 11: Discovery and Optimization of Molecular Glues </p><p class="Speaker">Moderators:<br />Yong Cang, PhD, Professor, ShanghaiTech University; Co-Founder & CSO, Degron Therapeutics<br />Murali Ramachandra, PhD, CEO, Aurigene Discovery Technologies, Ltd.</p><ul class="Abstract"><li>From induced proximity to glues</li><li>Strategies to identify and screen molecular glues</li><li>Value of serendipitous discovery versus rational design</li><li>Determination of selectivity of molecular glues</li><li>Importance of species selectivity for degraders</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Target Identification Strategies</u></p><p class="Session terciary-text">BREAKOUT 12: Leveraging Covalent Chemistries, Phenotypic Screening, Chemoproteomics Tools</p><p class="Speaker">Moderators:<br />Alexander Federation, PhD, Co-Founder & CEO, Talus Bioscience<br />Denise Field, PhD, Senior Principal Scientist, Chemical Biology and Proteomics, Pfizer<br />Steve Gygi, PhD, Professor, Department of Cell Biology, Harvard Medical School</p><ul class="Abstract"><li>How can proteomics be best used in the drug discovery pipeline?</li><li>Can traditional chemoproteomics and orthogonal methods help deconvolute “undruggable” targets?</li><li>What improvements are needed in developing good proteomic assays and screening platforms?</li><li>Leveraging covalent chemistry and induced proximity for drug discovery</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>GPCR-Based Drug Discovery</u></p><p class="Session terciary-text">BREAKOUT 13: Peptide Agonists for GPCRs</p><p class="Speaker">Moderator: Florence Brunel, PhD, Senior Principal Scientist, Novo Nordisk Inc</p><ul class="Abstract"><li>How will small molecule GPCR agonists compete with peptides?</li><li>What are the next GPCRs to be blockbusters?</li><li>What is the limitation to developing more peptide GPCR agonists? What are the new techniques to help solve these issues?</li></ul><p class="Session terciary-text">BREAKOUT 14: Innovations in GPCR-Hit Discovery</p><p class="Speaker">Moderator: Evan O'Brien, PhD, Postdoctoral Scholar, Laboratory of Brian Kobilka, Molecular & Cellular Physiology, Stanford University</p><ul class="Abstract"><li>Role of cryoEM</li><li>Impact of AI</li><li>DNA-Encoded Libraries (DEL) & GPCRs</li><li>New biophysical tools: SPR microscopy, single-molecule FRET</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Cancer Antibodies</u></p><p class="Session terciary-text">BREAKOUT 15: Strategies for Enhancing Antibody Efficiency and Selectivity</p><p class="Speaker">Moderator: Thomas Nittoli, PhD, Senior Director, Therapeutic Proteins, R&D Chemistry, Regeneron Pharmaceuticals, Inc.</p><ul class="Abstract"><li>Improving tissue penetration and targeting</li><li>Reducing immunogenicity and off-target effects</li><li>Optimizing antibody-drug conjugate design and development</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>Targeting Transcription Factors</u></p><p class="Session terciary-text">BREAKOUT 16: Leveraging Novel Strategies for Transcription Factors and Undruggable Targets</p><p class="Speaker">Moderators:<br />Kristy Stengel, PhD, Assistant Professor, Department of Cell Biology, Albert Einstein College of Medicine<br />Asad Taherbhoy, PhD, Director, Drug Discovery, Foghorn Therapeutics<br />William Tansey, PhD, Ingram Professor of Cancer Research, Professor of Cell & Development Biology, Vanderbilt University<br />Pamela Ting, PhD, Associate Director, Hematology, Novartis Institutes for BioMedical Research</p><ul class="Abstract"><li>Assays and screening strategies to identify modulators of transcription factors</li><li>Structural and mechanistic approaches for underlying mechanism of action</li><li>Emerging transcription factors as viable drug targets for the various indications</li><li>Designing potent, orally bioavailable drugs that target co-activators and inhibitors</li><li>Pursuing degradation as a therapeutic strategy for targeting transcription factors</li></ul><p class="Session secondary-text pad-bottom pad-top dark-blue"><u>AI/ML-Enabled Drug Discovery – Part 2</u></p><p class="Session terciary-text">BREAKOUT 17: How Successful Are AI/ML Approaches in Drug Development Today?</p><p class="Speaker">Moderators:<br />Shruthi Bharadwaj, PhD, Global Lead, Digital & Analytics, R&D Global Operations, Sanofi<br />Sean Gardner, MS, Scientific Program Manager, Office of Special Initiatives, NCATS, National Institutes of Health<br />Dmitri Kireev, PhD, Professor, Department of Chemistry, University of Missouri</p><ul class="Abstract"><li>How to develop AI/ML models able to predict outcomes that matter most (activity in animal models and, ultimately, in clinics)?</li><li>Can AI/ML make drug discovery more deterministic?</li><li>Is AI useful in improving the efficiency of virtual screening?</li><li>What support does this field need in order to thrive and succeed?</li></ul><p class="Session terciary-text">BREAKOUT 18: Using AI/ML for Lead and Target Discovery</p><p class="Speaker">Moderators:<br />Diane M. Joseph-McCarthy, PhD, Professor of the Practice, Biomedical Engineering, Boston University<br />Petrina Kamya, PhD, Global Head of AI Platforms, Vice President Insilico Medicine; President, Insilico Medicine Canada, Insilico<br />Harpreet Saini, PhD, Senior Director, Informatics, Astex Pharmaceuticals Ltd.</p><ul class="Abstract"><li>Areas where AI is highly impactful in drug discovery pipeline</li><li>Explainable/interpretable AI to understand model predictions/decisions</li><li>Strategies for reducing chemical search space</li><li>Scalable visualization techniques for large-scale data, e.g., single-cell data, spatial omics, cell-painting</li></ul></div> </div></div> </div> <div class="col-sm-3"> <div id="Contentplaceholder1_TDA1EA21B001_Col01" class="sf_colsIn pad-lr" data-sf-element="Column 2" data-placeholder-label="Column 2"><div class='sfContentBlock'> <br class="hidden-sm hidden-md hidden-lg" /><div class="social-icons"><a target="_blank" 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href="/synthetic-biology-drug-discovery" data-sf-ec-immutable="">Synthetic Biology for Drug Discovery & Development</a> <hr class="sidebar-rule" /><p class="sidebar-date">September 23-24</p><a href="/protacs-molecular-glues-part1" data-sf-ec-immutable="">Degraders & Molecular Glues – Part 1</a> <a href="/target-identification-strategies" data-sf-ec-immutable="">Emerging Drug Targets: Identification & Validation</a> <a href="/small-molecules-cancer-targets" data-sf-ec-immutable="">Small Molecules for Cancer Targets</a> <a href="/membrane-proteins" data-sf-ec-immutable="">Antibodies Against Membrane Protein Targets</a> <a href="/rna-dna-small-molecules" data-sf-ec-immutable="">RNA & DNA Targeting Small Molecule Drugs</a> <a href="/ai-ml-enabled-drug-discovery-part1" data-sf-ec-immutable="">AI/ML-Enabled Drug Discovery - Part 1</a> <a href="/targeting-mash-obesity" data-sf-ec-immutable="">Targeting MASH & Obesity <span class="new">NEW</span> </a> <hr class="sidebar-rule" /><p 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