Recombinant Human His6-USP25 Protein, CF (E-546) by R&D Systems, Part of Bio-Techne

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font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="E-546-050" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">E-546-050</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex 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nav-tabs nav-fill" id="productTab" role="tablist"> <li class="nav-item" role="presentation"> <a class="nav-link tab-anchor active" href="#tab-technical_data" id="technical_data-tab" data-toggle="tab" data-target="#technical_data" type="button" role="tab" aria-controls="technical_data" aria-selected="true"> <p class="m-0">Technical Data</p> </a> </li> <li class="nav-item" role="presentation"> <a class="nav-link tab-anchor " href="#tab-citations_reviews" id="citations_reviews-tab" data-toggle="tab" data-target="#citations_reviews" type="button" role="tab" aria-controls="citations_reviews" aria-selected="false"> <p class="m-0">Citations & Reviews</p> </a> </li> </ul> <div id="ProductTabContent" class="tab-content mb-3"> <div class="tab-pane fade show active" id="technical_data" role="tabpanel" aria-labelledby="technical_data-tab"> <div data-section="section-base--technical-anchors"> <ul class="product-pages-anchors nav mt-2"> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor active" href="#product-specifications"> Product Specifications</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#preparation--storage"> Preparation & Storage</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#background"> Background</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#product-documents"> Product Documents</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#specific-notices"> Specific Notices</a> </li> </ul> </div> <div id="key_details" class="py-5 bt-pp-border-bottom" data-section="section-base--key-details"> <h3>Key Product Details</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Sf 21 (baculovirus) </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Accession #</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <a href="https://www.ncbi.nlm.nih.gov/protein/Q9UHP3.4" class="a___link-external" target="_blank" rel="nofollow">Q9UHP3.4</a> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Conjugate</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Enzyme Activity </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/usp25/proteins-enzymes">View all USP25 Proteins and Enzymes »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="E-546" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <em>Spodoptera frugiperda</em>, <em>Sf</em> 21 (baculovirus)-derived human USP25 protein<br>Met1 - Arg1055 with a C-terminal 6-His tag </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Predicted Molecular Mass</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 123 kDa </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Activity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human His6-USP25 concentration of 0.1-1 mM. </div> </div> </div> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-protein--preparation-storage"> <h3>Formulation, Preparation and Storage</h3> <div class="datasheet_section"> <div class="row px-3"> <div class="col-xs-12 "> <div class="border-left border-right border-top text-center"> <h5 class="m-0 p-3 bg-dark-bt-blue text-white"> E-546 </h5> </div> <table class="ds_table_html table-bordered tablesaw tablesaw-stack"> <tbody> <tr> <td class="font-weight-bold">Formulation</td> <td class="w-75">Supplied as a solution in HEPES, NaCl and DTT.</td> </tr> <tr> <td class="font-weight-bold">Shipping</td> <td class="w-75">The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="font-weight-bold">Stability & Storage</td> <td class="w-75"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>6 months from date of receipt, -70 °C as supplied.</LI><LI>3 months, -70 °C under sterile conditions after opening.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: USP25</h3> <article class="product-data-wrapper"> <p>Ubiquitin Specific Peptidase 25 (USP25) is a cytoplasmic, Ubiquitin-specific deconjugating enzyme that belongs to the peptidase C19 family of deubiquitinating enzymes (1). It has been shown to be expressed as three tissue-specific isoforms: USP25a, USP25b, and USP25m (2). The canonical isoform, USP25a, is 1055 amino acids (aa) in length and has a predicted molecular weight of 122.2 kDa (2). Human USP25a shares 94% aa sequence identity with the mouse and rat orthologs. It is widely expressed with the highest levels being observed in fetal brain and adult testis (2). USP25b and USP25m are 1087 aa and 1125 aa in length with predicted molecular weights of 125.8 and 130 kDa, respectively. USP25b is found in all tissues except heart and skeletal muscle, while USP25m is exclusively expressed in heart and skeletal muscle (2). The catalytic domain of USP25 is found at aa 166-654 (3). USP25 also contains a Ubiquitin-associated domain (aa 16-57), a SUMO-interacting motif (aa 77-102) and two Ubiquitin-interacting motifs (aa 97-116 and 123-140), which appear to be required for in vitro hydrolysis of Lys48- and Lys63-linked poly-Ubiquitin chains (3,4). USP25 has been shown to interact with the non-receptor tyrosine kinase SYK, which phosphorylates USP25 on Tyr740, leading to a decrease in its intracellular levels (5). USP25 can also be SUMOylated on Lys99 and Lys141. This inhibits USP25 activity by impeding its binding to poly-Ubiquitin chains (3). USP25m can also be ubiquitinated on Lys99 and is thought to stimulate USP25m activity (6). USP25 has been shown to inhibit the degradation of endoplasmic reticulum proteins and to negatively regulate inflammatory responses induced by IL-17 (4,7). Additionally, USP25 has been found to be overexpressed in Down Syndrome fetal brains (1,2). USP25m is thought to be involved in the regulation of muscular differentiation and function. Its expression is up-regulated during myogenesis, and it has been shown to interact with three sarcomeric proteins critical for muscle differentiation and maintenance, ACTA1, FLNC, and MyBPC1 (8). </p> </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>References</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <ol><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Valero, R. <i>et al.</i> (1999) Genomics <b style="mso-bidi-font-weight: normal;">62</b>:395.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Valero, R. <i>et al</i>. (2001) Genome Biol. <b style="mso-bidi-font-weight: normal;">2</b>:RESEARCH00043.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Meulmeester, E. <i>et al</i>. (2008) Mol. Cell <b style="mso-bidi-font-weight: normal;">30</b>:610.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Blount, J.R. <i>et al.</i> (2012) PLoS One <b style="mso-bidi-font-weight: normal;">7</b>:e36542.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Cholay, M. <i>et al.</i> (2010) Exp. Cell Res. <b style="mso-bidi-font-weight: normal;">316</b>:667.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Denuc, A. <i>et al.</i> (2009) PLoS One <b style="mso-bidi-font-weight: normal;">4</b>:e5571.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Zhong, B. <i>et al.</i> (2012) Nat. Immunol. <b style="mso-bidi-font-weight: normal;">13</b>:1110.<o:p></o:p></div></li><li><div style="margin: 0in 0in 0pt;" class="MsoNormal">Bosch-Comas, A. <i>et al.</i> (2006) Cell. Mol. Life Sci. <b style="mso-bidi-font-weight: normal;">63</b>:723.<o:p></o:p></div></li></ol> </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Ubiquitin Specific Protease 25 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Ubiquitin Thiolesterase 25 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=29761" class="a___link-external" target="_blank" rel="nofollow">29761</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=30940" class="a___link-external" target="_blank" rel="nofollow">30940</a> (Mouse) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> USP25 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=Q9UHP3.4" class="a___link-external" target="_blank" rel="nofollow">Q9UHP3.4</a> </div> </div> </div> <h4 class="mt-3">Additional USP25 Products</h4> <ul class="list-unstyled"> <li><a href="/t/usp25" data-product="USP25">All Products for USP25 </a></li> <li><a href="/t/usp25/cdna-clones" data-application="USP25 cDNA Clones">USP25 cDNA Clones </a></li> <li><a href="/t/usp25/lysates" data-application="USP25 Lysates">USP25 Lysates </a></li> <li><a href="/t/usp25/antibodies" data-application="USP25 Primary Antibodies">USP25 Primary Antibodies </a></li> <li><a href="/t/usp25/proteins-enzymes" data-application="USP25 Proteins and Enzymes">USP25 Proteins and Enzymes </a></li> </ul> </div> <div id="product-documents" data-section="section-base--product-documents"> <div id="accordion" class="border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3"> Product Documents for Recombinant Human His6-USP25 Protein, CF </h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#accordion"> <div class="card-body"> <div class="row"> <div class="col-md-6"> <a href="https://resources.rndsystems.com/pdfs/datasheets/e-546.pdf" class="datasheet_link" target="_blank" rel="nofollow">Download Product Datasheets</a> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="product-coa-form" action="#coa-form" method="post" id="product-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> <p><strong>Note:</strong> Certificate of Analysis not available for kit components.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form novalidate="novalidate" data-drupal-selector="product-coa-form"> <div class="form-row align-items-center"> <div class="col-md-10 my-1"> <input data-drupal-selector="form-uk11d8aad5h0c4jrujd5g-cxhdd0tzv0newvhhb5rxu" type="hidden" name="form_build_id" value="form-Uk11d8aAd5h0C4jruJd5G-CxHDD0tZV0NewVhhb5RXU" /> <input data-drupal-selector="edit-product-coa-form" type="hidden" name="form_id" value="product_coa_form" /> <input data-drupal-selector="edit-product-code" type="hidden" name="product_code" value="E-546" /> <div class="js-form-item form-item pb-3 js-form-type-textfield form-item-lot-number js-form-item-lot-number form-no-label"> <input autocomplete="off" class="form-control cofa-lookup form-text" id="lot-number" placeholder="Search by lot number" data-drupal-selector="edit-lot-number" type="text" name="lot_number" value="" size="60" maxlength="128" /> </div> <input data-drupal-selector="edit-brand" type="hidden" name="brand" value="rnd" /> <input data-drupal-selector="edit-document-category" type="hidden" name="document_category" value="coa" /> </div> <div class="col-auto mb-3"> <input id="edit-submit" class="btn btn-primary cofa-btn button js-form-submit form-submit" data-drupal-selector="edit-submit" type="submit" name="op" value="Submit" /> </div> </div> </form> </div> <div id="pdf-result-rnd" class="col-md-6 mb-4 pdf-result datasheet-loading"></div> </section> </form> </div> </div> <div class="card-header"> <a class="collapsed" data-toggle="collapse" data-target="#collapse_three" aria-expanded="false" aria-controls="collapse_three" > <h5 class="mb-0"> SDS </h5> </a> </div> <div id="collapse_three" class="collapse rounded-bottom" aria-labelledby="heading_three" data-parent="#accordion"> <div class="card-body"> <div class="row sds-row"> <div class="select_wrapper col"> <select class="sds_country_select dropdown-chevron form-control mb-2" data-uri="https://aero.bio-techne.com/sds/pdf/e-546"> <option value="">Select SDS Language</option> <option value="cs-cz">Czech</option> <option value="da-dk">Danish</option> <option value="nl-nl">Dutch</option> <option value="en-us">English</option> <option value="de-de">German</option> <option value="fr-fr">French</option> <option value="hu-hu">Hungarian</option> <option value="it-it">Italian</option> <option value="nb-no">Norwegian</option> <option value="pl-pl">Polish</option> <option value="es-es">Spanish</option> <option value="sv-se">Swedish</option> </select> <span class="sds-pdf-result datasheet-loading"></span> </div> <div class="col my-3 pt-1 text-center text-lg-left"> <a class="sds-link datasheet_link datasheet-button-link text-wrap text-bt-blue" > Download SDS </a> </div> </div> </div> </div> </div> </div> <div id="specific-notices" class="py-5" data-section="section-base--specific-notices"> <h3>Product Specific Notices for Recombinant Human His6-USP25 Protein, CF </h3> <p></p><p>For research use only</p> </div> </div> <div class="tab-pane fade" id="citations_reviews" role="tabpanel" aria-labelledby="citations_reviews-tab"> <div data-section="section-base--technical-anchors"> <ul class="product-pages-anchors nav mt-2"> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor active" href="#citations"> Citations</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#reviews"> Reviews</a> </li> </ul> </div> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="E-546"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> <section id="reviews-tab-content-placeholder" class="tab-content-placeholder" data-id="reviews" data-product_code="e-546"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> <div class="tab-pane fade" id="protocols_faqs" role="tabpanel" 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Recombinant Human His6-USP25 Protein, CF (E-546) by R&D Systems, Part of Bio-Techne