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<div id="mw-content-text" class="mw-body-content"><script>function mfTempOpenSection(id){var block=document.getElementById("mf-section-"+id);block.className+=" open-block";block.previousSibling.className+=" open-block";}</script><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><section class="mf-section-0" id="mf-section-0"> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style>Riboflavin, also known as vitamin B2, is a <a href="/wiki/Vitamin" title="Vitamin">vitamin</a> found in food and sold as a <a href="/wiki/Dietary_supplement" title="Dietary supplement">dietary supplement</a>.<a href="#cite_note-ods-3">[3]</a> It is essential to the formation of two major <a href="/wiki/Coenzyme" class="mw-redirect" title="Coenzyme">coenzymes</a>, <a href="/wiki/Flavin_mononucleotide" title="Flavin mononucleotide">flavin mononucleotide</a> and <a href="/wiki/Flavin_adenine_dinucleotide" title="Flavin adenine dinucleotide">flavin adenine dinucleotide</a>. These coenzymes are involved in energy <a href="/wiki/Metabolism" title="Metabolism">metabolism</a>, <a href="/wiki/Cellular_respiration" title="Cellular respiration">cellular respiration</a>, and <a href="/wiki/Antibody" title="Antibody">antibody</a> production, as well as normal growth and development. The coenzymes are also required for the metabolism of <a href="/wiki/Niacin_(nutrient)" class="mw-redirect" title="Niacin (nutrient)">niacin</a>, <a href="/wiki/Vitamin_B6" title="Vitamin B6">vitamin B6</a>, and <a href="/wiki/Folate" title="Folate">folate</a>. Riboflavin is <a href="/wiki/Prescription_drug" title="Prescription drug">prescribed</a> to treat <a href="/wiki/Corneal_ectatic_disorders" title="Corneal ectatic disorders">corneal thinning</a>, and taken orally, may reduce the incidence of <a href="/wiki/Migraine_headache" class="mw-redirect" title="Migraine headache">migraine headaches</a> in adults. <table class="infobox" style="border-spacing:2px;"><caption class="infobox-title">Riboflavin</caption><tbody><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:Riboflavin.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/36/Riboflavin.svg/250px-Riboflavin.svg.png" decoding="async" width="220" height="215" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/36/Riboflavin.svg/330px-Riboflavin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/36/Riboflavin.svg/440px-Riboflavin.svg.png 2x" data-file-width="440" data-file-height="430"></a></td></tr><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:Riboflavin-based-on-xtal-3D-bs-17.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Riboflavin-based-on-xtal-3D-bs-17.png/250px-Riboflavin-based-on-xtal-3D-bs-17.png" decoding="async" width="220" height="245" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Riboflavin-based-on-xtal-3D-bs-17.png/330px-Riboflavin-based-on-xtal-3D-bs-17.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/22/Riboflavin-based-on-xtal-3D-bs-17.png/500px-Riboflavin-based-on-xtal-3D-bs-17.png 2x" data-file-width="2085" data-file-height="2319"></a><div class="infobox-caption">Chemical structure</div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Many<a href="#cite_note-drugs-1">[1]</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">lactochrome, lactoflavin, vitamin G<a href="#cite_note-anm-2">[2]</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/Riboflavin.html">Monograph</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><abbr class="country-name" title="United States">US</abbr> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Riboflavin">Riboflavin</a></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a>, <a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular">intramuscular</a>, <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_A11" title="ATC code A11">A11HA04</a> (<a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=A11HA04">WHO</a>) <a href="/wiki/ATC_code_S01" title="ATC code S01">S01XA26</a> (<a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=S01XA26">WHO</a>)</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><abbr class="country-name" title="United States">US</abbr>: Dietary supplement</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination half-life</a></th><td class="infobox-data">66 to 84 minutes</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">Urine</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">7,8-Dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=83-88-5">83-88-5</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <abbr title="Compound ID">CID</abbr></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/493570">493570</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6578">6578</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00140">DB00140</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.431981.html">431981</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/TLM2976OFR">TLM2976OFR</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D00050">D00050</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17015">CHEBI:17015</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1534">ChEMBL1534</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y[<a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">EMBL</a>]</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/E_number" title="E number">E number</a></th><td class="infobox-data">E101, E101(iii) <a href="/wiki/E_number#E100%E2%80%93E199" title="E number">(colours)</a> <a href="https://www.wikidata.org/wiki/Q130365#P628" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20"></a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> (<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021777">DTXSID8021777</a> <a href="https://www.wikidata.org/wiki/Q130365#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20"></a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard">ECHA InfoCard</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.001.370">100.001.370</a> <a href="https://www.wikidata.org/wiki/Q130365#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20"></a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data">C17H20N4O6</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data">376.369 g·mol−1</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=c12cc%28C%29c%28C%29cc1N%3DC3C%28%3DO%29NC%28%3DO%29N%3DC3N2C%5BC%40H%5D%28O%29%5BC%40H%5D%28O%29%5BC%40H%5D%28O%29CO">Interactive image</a></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">c12cc(C)c(C)cc1N=C3C(=O)NC(=O)N=C3N2C[C@H](O)[C@H](O)[C@H](O)CO</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1 <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:AUNGANRZJHBGPY-SCRDCRAPSA-N <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600">Y</div></li></ul> </div></td></tr></tbody></table> <a href="/wiki/Riboflavin_deficiency" class="mw-redirect" title="Riboflavin deficiency">Riboflavin deficiency</a> is rare and is usually accompanied by deficiencies of other vitamins and nutrients. It may be prevented or treated by oral supplements or by injections. As a <a href="/wiki/Water-soluble" class="mw-redirect" title="Water-soluble">water-soluble</a> vitamin, any riboflavin consumed in excess of nutritional requirements is not stored; it is either not absorbed or is absorbed and quickly <a href="/wiki/Clearance_(pharmacology)" title="Clearance (pharmacology)">excreted in urine</a>, causing the urine to have a bright yellow tint. Natural sources of riboflavin include meat, fish and fowl, eggs, dairy products, green vegetables, mushrooms, and almonds. Some countries require its addition to <a href="/wiki/Food_grains" class="mw-redirect" title="Food grains">grains</a>.<a href="#cite_note-ods-3">[3]</a> In its purified, solid form, it is a water-soluble yellow-orange crystalline powder. In addition to its function as a vitamin, it is used as a <a href="/wiki/Food_coloring" title="Food coloring">food coloring agent</a>. Biosynthesis takes place in bacteria, fungi and plants, but not animals. Industrial synthesis of riboflavin was initially achieved using a chemical process, but current commercial manufacturing relies on <a href="/wiki/Fermentation_in_food_processing" title="Fermentation in food processing">fermentation</a> methods using strains of <a href="/wiki/Fungus" title="Fungus">fungi</a> and <a href="/wiki/Genetic_engineering" title="Genetic engineering">genetically modified</a> bacteria. <div id="toc" class="toc" role="navigation" aria-labelledby="mw-toc-heading"><input type="checkbox" role="button" id="toctogglecheckbox" class="toctogglecheckbox" style="display:none"><div class="toctitle" lang="en" dir="ltr"><h2 id="mw-toc-heading">Contents</h2><label class="toctogglelabel" for="toctogglecheckbox"></label></div> <ul> <li class="toclevel-1 tocsection-1"><a href="#Definition">1 Definition</a></li> <li class="toclevel-1 tocsection-2"><a href="#Functions">2 Functions</a> <ul> <li class="toclevel-2 tocsection-3"><a href="#Redox_reactions">2.1 Redox reactions</a></li> <li class="toclevel-2 tocsection-4"><a href="#Micronutrient_metabolism">2.2 Micronutrient metabolism</a></li> </ul> </li> <li class="toclevel-1 tocsection-5"><a href="#Synthesis">3 Synthesis</a> <ul> <li class="toclevel-2 tocsection-6"><a href="#Biosynthesis">3.1 Biosynthesis</a></li> <li class="toclevel-2 tocsection-7"><a href="#Industrial_synthesis">3.2 Industrial synthesis</a></li> <li class="toclevel-2 tocsection-8"><a href="#Laboratory_synthesis">3.3 Laboratory synthesis</a></li> </ul> </li> <li class="toclevel-1 tocsection-9"><a href="#Uses">4 Uses</a> <ul> <li class="toclevel-2 tocsection-10"><a href="#Treatment_of_corneal_thinning">4.1 Treatment of corneal thinning</a></li> <li class="toclevel-2 tocsection-11"><a href="#Migraine_prevention">4.2 Migraine prevention</a></li> <li class="toclevel-2 tocsection-12"><a href="#Food_coloring">4.3 Food coloring</a></li> </ul> </li> <li class="toclevel-1 tocsection-13"><a href="#Dietary_recommendations">5 Dietary recommendations</a> <ul> <li class="toclevel-2 tocsection-14"><a href="#Safety">5.1 Safety</a></li> <li class="toclevel-2 tocsection-15"><a href="#Labeling">5.2 Labeling</a></li> </ul> </li> <li class="toclevel-1 tocsection-16"><a href="#Sources">6 Sources</a> <ul> <li class="toclevel-2 tocsection-17"><a href="#Fortification">6.1 Fortification</a></li> </ul> </li> <li class="toclevel-1 tocsection-18"><a href="#Absorption,_metabolism,_excretion">7 Absorption, metabolism, excretion</a></li> <li class="toclevel-1 tocsection-19"><a href="#Deficiency">8 Deficiency</a> <ul> <li class="toclevel-2 tocsection-20"><a href="#Prevalence">8.1 Prevalence</a></li> <li class="toclevel-2 tocsection-21"><a href="#Signs_and_symptoms">8.2 Signs and symptoms</a></li> <li class="toclevel-2 tocsection-22"><a href="#Risk_factors">8.3 Risk factors</a></li> <li class="toclevel-2 tocsection-23"><a href="#Causes">8.4 Causes</a></li> <li class="toclevel-2 tocsection-24"><a href="#Diagnosis_and_assessment">8.5 Diagnosis and assessment</a></li> </ul> </li> <li class="toclevel-1 tocsection-25"><a href="#History">9 History</a></li> <li class="toclevel-1 tocsection-26"><a href="#References">10 References</a></li> </ul> </div> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(1)"><h2 id="Definition">Definition</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=1" title="Edit section: Definition" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-1 collapsible-block" id="mf-section-1"> Riboflavin, also known as vitamin B2, is a water-soluble <a href="/wiki/Vitamin" title="Vitamin">vitamin</a> and is one of the <a href="/wiki/B_vitamins" title="B vitamins">B vitamins</a>.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-DRItext-4">[4]</a><a href="#cite_note-PKIN2020B2-5">[5]</a> Unlike <a href="/wiki/Folate" title="Folate">folate</a> and <a href="/wiki/Vitamin_B6" title="Vitamin B6">vitamin B6</a>, which occur in several chemically related forms known as <a href="/wiki/Vitamer" title="Vitamer">vitamers</a>, riboflavin is only one chemical compound. It is a starting compound in the synthesis of the coenzymes <a href="/wiki/Flavin_mononucleotide" title="Flavin mononucleotide">flavin mononucleotide</a> (FMN, also known as riboflavin-5'-phosphate) and <a href="/wiki/Flavin_adenine_dinucleotide" title="Flavin adenine dinucleotide">flavin adenine dinucleotide</a> (FAD). FAD is the more abundant form of flavin, reported to bind to 75% of the number of flavin-dependent protein encoded genes in the all-species genome (the flavoproteome)<a href="#cite_note-Lienhart_2013-6">[6]</a><a href="#cite_note-7">[7]</a> and serves as a co-enzyme for 84% of human-encoded flavoproteins.<a href="#cite_note-Lienhart_2013-6">[6]</a> In its purified, solid form, riboflavin is a yellow-orange <a href="/wiki/Crystal" title="Crystal">crystalline</a> powder with a slight odor and bitter taste. It is soluble in polar <a href="/wiki/Solvent" title="Solvent">solvents</a>, such as water and aqueous sodium chloride solutions, and slightly soluble in alcohols. It is not soluble in non-polar or weakly polar organic solvents such as chloroform, benzene or acetone.<a href="#cite_note-pubchem-8">[8]</a> In solution or during dry storage as a powder, riboflavin is heat stable if not exposed to light. When heated to decompose, it releases toxic fumes containing <a href="/wiki/Nitric_oxide" title="Nitric oxide">nitric oxide</a>.<a href="#cite_note-pubchem-8">[8]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(2)"><h2 id="Functions">Functions</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=2" title="Edit section: Functions" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-2 collapsible-block" id="mf-section-2"> Riboflavin is essential to the formation of two major coenzymes, FMN and FAD.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-Mewies-9">[9]</a> These coenzymes are involved in <a href="/wiki/Energy_metabolism" class="mw-redirect" title="Energy metabolism">energy metabolism</a>, <a href="/wiki/Cell_respiration" class="mw-redirect" title="Cell respiration">cell respiration</a>, <a href="/wiki/Antibody" title="Antibody">antibody</a> production, growth and development.<a href="#cite_note-Mewies-9">[9]</a> Riboflavin is essential for the metabolism of <a href="/wiki/Carbohydrate" title="Carbohydrate">carbohydrates</a>, <a href="/wiki/Protein_(nutrient)" title="Protein (nutrient)">protein</a> and <a href="/wiki/Fat" title="Fat">fats</a>.<a href="#cite_note-ods-3">[3]</a> FAD contributes to the conversion of <a href="/wiki/Tryptophan" title="Tryptophan">tryptophan</a> to <a href="/wiki/Niacin_(nutrient)" class="mw-redirect" title="Niacin (nutrient)">niacin</a> (vitamin B3)<a href="#cite_note-lpi-10">[10]</a> and the conversion of vitamin B6 to the coenzyme <a href="/wiki/Pyridoxal_phosphate" title="Pyridoxal phosphate">pyridoxal 5'-phosphate</a> requires FMN.<a href="#cite_note-lpi-10">[10]</a> Riboflavin is involved in maintaining normal circulating levels of <a href="/wiki/Homocysteine" title="Homocysteine">homocysteine</a>; in riboflavin deficiency, homocysteine levels increase, elevating the risk of <a href="/wiki/Cardiovascular_diseases" class="mw-redirect" title="Cardiovascular diseases">cardiovascular diseases</a>.<a href="#cite_note-lpi-10">[10]</a> <div class="mw-heading mw-heading3"><h3 id="Redox_reactions">Redox reactions</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=3" title="Edit section: Redox reactions" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> <a href="/wiki/Redox" title="Redox">Redox reactions</a> are processes that involve the <a href="/wiki/Electron_transfer" title="Electron transfer">transfer of electrons</a>. The flavin coenzymes support the function of roughly 70-80 flavoenzymes in humans (and hundreds more across all organisms, including those encoded by <a href="/wiki/Archaea" title="Archaea">archeal</a>, bacterial and fungal <a href="/wiki/Genome" title="Genome">genomes</a>) that are responsible for one- or two-electron redox reactions which capitalize on the ability of flavins to be converted between oxidized, half-reduced and fully reduced forms.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-PKIN2020B2-5">[5]</a> FAD is also required for the activity of <a href="/wiki/Glutathione_reductase" title="Glutathione reductase">glutathione reductase</a>, an essential enzyme in the formation of the <a href="/wiki/Endogeny_(biology)" title="Endogeny (biology)">endogenous</a> <a href="/wiki/Antioxidant" title="Antioxidant">antioxidant</a>, <a href="/wiki/Glutathione" title="Glutathione">glutathione</a>.<a href="#cite_note-lpi-10">[10]</a> <div class="mw-heading mw-heading3"><h3 id="Micronutrient_metabolism">Micronutrient metabolism</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=4" title="Edit section: Micronutrient metabolism" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Riboflavin, FMN, and FAD are involved in the metabolism of niacin, vitamin B6, and <a href="/wiki/Folate" title="Folate">folate</a>.<a href="#cite_note-DRItext-4">[4]</a> The synthesis of the niacin-containing coenzymes, <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NAD</a> and <a href="/wiki/Nicotinamide_adenine_dinucleotide_phosphate" title="Nicotinamide adenine dinucleotide phosphate">NADP</a>, from tryptophan involves the FAD-dependent enzyme, <a href="/wiki/Kynurenine_3-monooxygenase" title="Kynurenine 3-monooxygenase">kynurenine 3-monooxygenase</a>. Dietary deficiency of riboflavin can decrease the production of NAD and NADP, thereby promoting niacin deficiency.<a href="#cite_note-DRItext-4">[4]</a> Conversion of vitamin B6 to its coenzyme, <a href="/wiki/Pyridoxal_5%27-phosphate" class="mw-redirect" title="Pyridoxal 5'-phosphate">pyridoxal 5'-phosphate</a>, involves the enzyme, <a href="/wiki/Pyridoxine_5%27-phosphate_oxidase" class="mw-redirect" title="Pyridoxine 5'-phosphate oxidase">pyridoxine 5'-phosphate oxidase</a>, which requires FMN.<a href="#cite_note-DRItext-4">[4]</a> An enzyme involved in folate metabolism, <a href="/wiki/5,10-methylenetetrahydrofolate" class="mw-redirect" title="5,10-methylenetetrahydrofolate">5,10-methylenetetrahydrofolate</a> <a href="/wiki/Reductase" class="mw-redirect" title="Reductase">reductase</a>, requires FAD to form the amino acid, <a href="/wiki/Methionine" title="Methionine">methionine</a>, from homocysteine.<a href="#cite_note-DRItext-4">[4]</a> Riboflavin deficiency appears to impair the metabolism of the <a href="/wiki/Mineral_(nutrient)" title="Mineral (nutrient)">dietary mineral</a>, <a href="/wiki/Iron" title="Iron">iron</a>, which is essential to the production of <a href="/wiki/Hemoglobin" title="Hemoglobin">hemoglobin</a> and <a href="/wiki/Red_blood_cell" title="Red blood cell">red blood cells</a>. Alleviating riboflavin deficiency in people who are deficient in both riboflavin and iron improves the effectiveness of <a href="/wiki/Iron_supplement" title="Iron supplement">iron supplementation</a> for treating <a href="/wiki/Iron-deficiency_anemia" title="Iron-deficiency anemia">iron-deficiency anemia</a>.<a href="#cite_note-11">[11]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(3)"><h2 id="Synthesis">Synthesis</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=5" title="Edit section: Synthesis" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-3 collapsible-block" id="mf-section-3"> <div class="mw-heading mw-heading3"><h3 id="Biosynthesis">Biosynthesis</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=6" title="Edit section: Biosynthesis" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Biosynthesis takes place in bacteria, fungi and plants, but not animals.<a href="#cite_note-PKIN2020B2-5">[5]</a> The biosynthetic precursors to riboflavin are <a href="/wiki/Ribulose_5-phosphate" title="Ribulose 5-phosphate">ribulose 5-phosphate</a> and <a href="/wiki/Guanosine_triphosphate" title="Guanosine triphosphate">guanosine triphosphate</a>. The former is converted to L-3,4-dihydroxy-2-butanone-4-phosphate while the latter is transformed in a series of reactions that lead to 5-amino-6-(D-ribitylamino)uracil. These two compounds are then the substrates for the penultimate step in the pathway, catalysed by the enzyme <a href="/wiki/Lumazine_synthase" title="Lumazine synthase">lumazine synthase</a> in reaction <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/2.5.1.78">2.5.1.78</a>.<a href="#cite_note-Bacher-12">[12]</a><a href="#cite_note-Metacyc-13">[13]</a><a href="#cite_note-14">[14]</a> <dl><dd><a href="/wiki/File:Lumazine_synthase_reaction.svg" class="mw-file-description"><noscript><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Lumazine_synthase_reaction.svg/512px-Lumazine_synthase_reaction.svg.png" decoding="async" width="512" height="167" class="mw-file-element" data-file-width="512" data-file-height="167"></noscript><span class="lazy-image-placeholder" style="width: 512px;height: 167px;" data-mw-src="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Lumazine_synthase_reaction.svg/512px-Lumazine_synthase_reaction.svg.png" data-width="512" data-height="167" data-mw-srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Lumazine_synthase_reaction.svg/768px-Lumazine_synthase_reaction.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/22/Lumazine_synthase_reaction.svg/1024px-Lumazine_synthase_reaction.svg.png 2x" data-class="mw-file-element"> </a></dd></dl> In the final step of the biosynthesis, two molecules of <a href="/wiki/6,7-dimethyl-8-ribityllumazine" class="mw-redirect" title="6,7-dimethyl-8-ribityllumazine">6,7-dimethyl-8-ribityllumazine</a> are combined by the enzyme <a href="/wiki/Riboflavin_synthase" title="Riboflavin synthase">riboflavin synthase</a> in a <a href="/wiki/Dismutation" class="mw-redirect" title="Dismutation">dismutation</a> reaction. This generates one molecule of riboflavin and one of 5-amino-6-(D-ribitylamino) uracil. The latter is recycled to the previous reaction in the sequence.<a href="#cite_note-Bacher-12">[12]</a><a href="#cite_note-Metacyc-13">[13]</a> <dl><dd><a href="/wiki/File:Riboflavin_synthase_dismutation.svg" class="mw-file-description"><noscript><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Riboflavin_synthase_dismutation.svg/512px-Riboflavin_synthase_dismutation.svg.png" decoding="async" width="512" height="160" class="mw-file-element" data-file-width="512" data-file-height="160"></noscript><span class="lazy-image-placeholder" style="width: 512px;height: 160px;" data-mw-src="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Riboflavin_synthase_dismutation.svg/512px-Riboflavin_synthase_dismutation.svg.png" data-width="512" data-height="160" data-mw-srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Riboflavin_synthase_dismutation.svg/768px-Riboflavin_synthase_dismutation.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/33/Riboflavin_synthase_dismutation.svg/1024px-Riboflavin_synthase_dismutation.svg.png 2x" data-class="mw-file-element"> </a></dd></dl> Conversions of riboflavin to the <a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">cofactors</a> FMN and FAD are carried out by the enzymes <a href="/wiki/Riboflavin_kinase" title="Riboflavin kinase">riboflavin kinase</a> and <a href="/wiki/FMN_adenylyltransferase" title="FMN adenylyltransferase">FAD synthetase</a> acting sequentially.<a href="#cite_note-Metacyc-13">[13]</a><a href="#cite_note-15">[15]</a> <dl><dd><figure class="mw-default-size skin-invert-image" typeof="mw:File/Thumb"><a href="/wiki/File:FAD_Synthesis.png" class="mw-file-description"><noscript><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/FAD_Synthesis.png/250px-FAD_Synthesis.png" decoding="async" width="220" height="392" class="mw-file-element" data-file-width="468" data-file-height="833"></noscript><span class="lazy-image-placeholder" style="width: 220px;height: 392px;" data-mw-src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/FAD_Synthesis.png/250px-FAD_Synthesis.png" data-width="220" data-height="392" data-mw-srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/FAD_Synthesis.png/330px-FAD_Synthesis.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/FAD_Synthesis.png/440px-FAD_Synthesis.png 2x" data-class="mw-file-element"> </a><figcaption>Riboflavin is the biosynthetic precursor of FMN and FAD</figcaption></figure></dd></dl> <div class="mw-heading mw-heading3"><h3 id="Industrial_synthesis">Industrial synthesis</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=7" title="Edit section: Industrial synthesis" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Micrococcus_riboflavin.jpg" class="mw-file-description"><noscript><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Micrococcus_riboflavin.jpg/250px-Micrococcus_riboflavin.jpg" decoding="async" width="220" height="148" class="mw-file-element" data-file-width="5393" data-file-height="3625"></noscript><span class="lazy-image-placeholder" style="width: 220px;height: 148px;" data-mw-src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Micrococcus_riboflavin.jpg/250px-Micrococcus_riboflavin.jpg" data-width="220" data-height="148" data-mw-srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Micrococcus_riboflavin.jpg/330px-Micrococcus_riboflavin.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Micrococcus_riboflavin.jpg/500px-Micrococcus_riboflavin.jpg 2x" data-class="mw-file-element"> </a><figcaption>Cultures of Micrococcus luteus growing on pyridine (left) and succinic acid (right). The pyridine culture has turned yellow from the accumulation of riboflavin.<a href="#cite_note-Sims1992-16">[16]</a></figcaption></figure> The industrial-scale production of riboflavin uses various microorganisms, including <a href="/wiki/Mold_(fungus)" class="mw-redirect" title="Mold (fungus)">filamentous fungi</a> such as <a href="/wiki/Ashbya_gossypii" class="mw-redirect" title="Ashbya gossypii">Ashbya gossypii</a>, <a href="/wiki/Candida_famata" class="mw-redirect" title="Candida famata">Candida famata</a> and Candida flaveri, as well as the <a href="/wiki/Bacteria" title="Bacteria">bacteria</a> <a href="/wiki/Corynebacterium" title="Corynebacterium">Corynebacterium</a> ammoniagenes and <a href="/wiki/Bacillus_subtilis" title="Bacillus subtilis">Bacillus subtilis</a>. B. subtilis that has been genetically modified to both increase the production of riboflavin and to introduce an antibiotic (<a href="/wiki/Ampicillin" title="Ampicillin">ampicillin</a>) resistance marker, is employed at a commercial scale to produce riboflavin for <a href="/wiki/Animal_feed" title="Animal feed">feed</a> and food fortification.<a href="#cite_note-Stahmann-17">[17]</a> By 2012, over 4,000 tonnes per annum were produced by such fermentation processes.<a href="#cite_note-Anie-18">[18]</a> In the presence of high concentrations of hydrocarbons or aromatic compounds, some bacteria overproduce riboflavin, possibly as a protective mechanism. One such organism is <a href="/wiki/Micrococcus_luteus" title="Micrococcus luteus">Micrococcus luteus</a> (<a href="/wiki/American_Type_Culture_Collection" class="mw-redirect" title="American Type Culture Collection">American Type Culture Collection</a> strain number ATCC 49442), which develops a yellow color due to production of riboflavin while growing on pyridine, but not when grown on other substrates, such as succinic acid.<a href="#cite_note-Sims1992-16">[16]</a> <div class="mw-heading mw-heading3"><h3 id="Laboratory_synthesis">Laboratory synthesis</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=8" title="Edit section: Laboratory synthesis" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> The first <a href="/wiki/Total_synthesis" title="Total synthesis">total synthesis</a> of riboflavin was carried out by <a href="/wiki/Richard_Kuhn" title="Richard Kuhn">Richard Kuhn</a>'s group.<a href="#cite_note-Anie-18">[18]</a><a href="#cite_note-19">[19]</a> A substituted <a href="/wiki/Aniline" title="Aniline">aniline</a>, produced by <a href="/wiki/Reductive_amination" title="Reductive amination">reductive amination</a> using <a href="/wiki/D-ribose" class="mw-redirect" title="D-ribose">D-ribose</a>, was <a href="/wiki/Condensation_reaction" title="Condensation reaction">condensed</a> with <a href="/wiki/Alloxan" title="Alloxan">alloxan</a> in the final step: <dl><dd><a href="/wiki/File:Riboflavin_synthesis.svg" class="mw-file-description"><noscript><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Riboflavin_synthesis.svg/512px-Riboflavin_synthesis.svg.png" decoding="async" width="512" height="181" class="mw-file-element" data-file-width="512" data-file-height="181"></noscript><span class="lazy-image-placeholder" style="width: 512px;height: 181px;" data-mw-src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Riboflavin_synthesis.svg/512px-Riboflavin_synthesis.svg.png" data-width="512" data-height="181" data-mw-srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Riboflavin_synthesis.svg/768px-Riboflavin_synthesis.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Riboflavin_synthesis.svg/1024px-Riboflavin_synthesis.svg.png 2x" data-class="mw-file-element"> </a></dd></dl> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(4)"><h2 id="Uses">Uses</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=9" title="Edit section: Uses" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-4 collapsible-block" id="mf-section-4"> <div class="mw-heading mw-heading3"><h3 id="Treatment_of_corneal_thinning">Treatment of corneal thinning</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=10" title="Edit section: Treatment of corneal thinning" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> <a href="/wiki/Keratoconus" title="Keratoconus">Keratoconus</a> is the most common form of <a href="/wiki/Corneal_ectasia" class="mw-redirect" title="Corneal ectasia">corneal ectasia</a>, a progressive thinning of the cornea. The condition is treated by <a href="/wiki/Corneal_cross-linking" title="Corneal cross-linking">corneal collagen cross-linking</a>, which increases corneal stiffness. Cross-linking is achieved by applying a <a href="/wiki/Topical_medication" title="Topical medication">topical</a> riboflavin solution to the cornea, which is then exposed to <a href="/wiki/Ultraviolet#UVA" title="Ultraviolet">ultraviolet A</a> light.<a href="#cite_note-20">[20]</a><a href="#cite_note-21">[21]</a> <div class="mw-heading mw-heading3"><h3 id="Migraine_prevention">Migraine prevention</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=11" title="Edit section: Migraine prevention" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> In its 2012 guidelines, the <a href="/wiki/American_Academy_of_Neurology" title="American Academy of Neurology">American Academy of Neurology</a> stated that high-dose riboflavin (400 mg) is "probably effective and should be considered for migraine prevention,"<a href="#cite_note-Holland-22">[22]</a> a recommendation also provided by the UK National Migraine Centre.<a href="#cite_note-nmc-23">[23]</a> A 2017 review reported that daily riboflavin taken at 400 mg per day for at least three months may reduce the frequency of <a href="/wiki/Migraine" title="Migraine">migraine</a> headaches in adults.<a href="#cite_note-Thompson2017-24">[24]</a> Research on high-dose riboflavin for migraine prevention or treatment in children and adolescents is inconclusive, and so supplements are not recommended.<a href="#cite_note-drugs-1">[1]</a><a href="#cite_note-ods-3">[3]</a><a href="#cite_note-Sherwood-25">[25]</a> <div class="mw-heading mw-heading3"><h3 id="Food_coloring">Food coloring</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=12" title="Edit section: Food coloring" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Riboflavin is used as a <a href="/wiki/Food_coloring" title="Food coloring">food coloring</a> (yellow-orange crystalline powder),<a href="#cite_note-pubchem-8">[8]</a> and is designated with the <a href="/wiki/E_number" title="E number">E number</a>, E101, in Europe for use as a <a href="/wiki/Food_additive" title="Food additive">food additive</a>.<a href="#cite_note-UKFSA-26">[26]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(5)"><h2 id="Dietary_recommendations">Dietary recommendations</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=13" title="Edit section: Dietary recommendations" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-5 collapsible-block" id="mf-section-5"> The <a href="/wiki/National_Academy_of_Medicine" title="National Academy of Medicine">National Academy of Medicine</a> updated the Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for riboflavin in 1998. The EARs<a class="external text" href="https://en.wikipedia.org/w/index.php?title=Riboflavin&action=edit">[update]</a> for riboflavin for women and men aged 14 and over are 0.9 mg/day and 1.1 mg/day, respectively; the RDAs are 1.1 and 1.3 mg/day, respectively. RDAs are higher than EARs to provide adequate intake levels for individuals with higher than average requirements. The RDA during pregnancy is 1.4 mg/day and the RDA for lactating females is 1.6 mg/day. For infants up to the age of 12 months, the Adequate Intake (AI) is 0.3–0.4 mg/day and for children aged 1–13 years the RDA increases with age from 0.5 to 0.9 mg/day. As for safety, the IOM sets <a href="/wiki/Tolerable_upper_intake_level" class="mw-redirect" title="Tolerable upper intake level">tolerable upper intake levels</a> (ULs) for vitamins and minerals when evidence is sufficient. In the case of riboflavin there is no UL, as there is no human data for adverse effects from high doses. Collectively the EARs, RDAs, AIs and ULs are referred to as <a href="/wiki/Dietary_Reference_Intake" title="Dietary Reference Intake">Dietary Reference Intakes</a> (DRIs).<a href="#cite_note-DRItext-4">[4]</a><a href="#cite_note-Gropper_S.S._2009,_P329-333-27">[27]</a> The <a href="/wiki/European_Food_Safety_Authority" title="European Food Safety Authority">European Food Safety Authority</a> (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in United States. For women and men aged 15 and older the PRI is set at 1.6 mg/day. The PRI during pregnancy is 1.9 mg/day and the PRI for lactating females is 2.0 mg/day. For children aged 1–14 years the PRIs increase with age from 0.6 to 1.4 mg/day. These PRIs are higher than the U.S. RDAs.<a href="#cite_note-28">[28]</a><a href="#cite_note-EFSA_PRI-29">[29]</a> The EFSA also considered the maximum safe intake and like the U.S. National Academy of Medicine, decided that there was not sufficient information to set an UL.<a href="#cite_note-30">[30]</a> <table class="wikitable" style="float: right; font-size: 80%; text-align: center; margin-left: 2em"> <tbody><tr> <td colspan="2" style="background: blue; color: white; font-size: 110%; text-align: center;">Recommended Dietary Allowances United States </td></tr> <tr> <th scope="col" width="8em">Age group (years) </th> <th scope="col" width="8em">RDA for riboflavin (mg/d)<a href="#cite_note-DRItext-4">[4]</a> </th></tr> <tr> <td>0–6 months</td> <td>0.3* </td></tr> <tr> <td>6–12 months</td> <td>0.4* </td></tr> <tr> <td>1–3</td> <td>0.5 </td></tr> <tr> <td>4–8</td> <td>0.6 </td></tr> <tr> <td>9–13</td> <td>0.9 </td></tr> <tr> <td>Females 14–18</td> <td>1.0 </td></tr> <tr> <td>Males 14–18</td> <td>1.3 </td></tr> <tr> <td>Females 19+</td> <td>1.1 </td></tr> <tr> <td>Males 19+</td> <td>1.3 </td></tr> <tr> <td>Pregnant females</td> <td>1.4 </td></tr> <tr> <td>Lactating females</td> <td>1.6 </td></tr> <tr> <td colspan="2" style="text-align: center;">* Adequate intake for infants, no RDA/RDI yet established<a href="#cite_note-DRItext-4">[4]</a> </td></tr> <tr> <td colspan="2" style="background: blue; color: white; font-size: 110%; text-align: center;">Population Reference Intakes European Union </td></tr> <tr> <th scope="col" width="8em">Age group (years) </th> <th scope="col" width="8em">PRI for riboflavin (mg/d)<a href="#cite_note-EFSA_PRI-29">[29]</a> </th></tr> <tr> <td>7–11 months</td> <td>0.4 </td></tr> <tr> <td>1–3</td> <td>0.6 </td></tr> <tr> <td>4–6</td> <td>0.7 </td></tr> <tr> <td>7–10</td> <td>1.0 </td></tr> <tr> <td>11–14</td> <td>1.4 </td></tr> <tr> <td>15–adult</td> <td>1.6 </td></tr> <tr> <td>Pregnant females</td> <td>1.9 </td></tr> <tr> <td>Lactating females</td> <td>2.0 </td></tr> </tbody></table> <div class="mw-heading mw-heading3"><h3 id="Safety">Safety</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=14" title="Edit section: Safety" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> In humans, there is no evidence for riboflavin toxicity produced by excessive intakes and absorption becomes less efficient as dosage increases. Any excess riboflavin is excreted via the <a href="/wiki/Kidney" title="Kidney">kidneys</a> into <a href="/wiki/Urine" title="Urine">urine</a>, resulting in a bright yellow color known as flavinuria.<a href="#cite_note-PKIN2020B2-5">[5]</a><a href="#cite_note-Gropper_S.S._2009,_P329-333-27">[27]</a><a href="#cite_note-MayoClinic-31">[31]</a> During a clinical trial on the effectiveness of riboflavin for treating the frequency and severity of migraines, subjects were given up to 400 mg of riboflavin orally per day for periods of 3–12 months. Abdominal pains and <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a> were among the <a href="/wiki/Side_effect" title="Side effect">side effects</a> reported.<a href="#cite_note-Thompson2017-24">[24]</a> <div class="mw-heading mw-heading3"><h3 id="Labeling">Labeling</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=15" title="Edit section: Labeling" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> For U.S. food and dietary supplement labeling purposes the amount in a serving is expressed as a percent of Daily Value (%DV). For riboflavin labeling purposes 100% of the Daily Value was 1.7 mg, but as of May 27, 2016, it was revised to 1.3 mg to bring it into agreement with the RDA.<a href="#cite_note-FedReg-32">[32]</a><a href="#cite_note-33">[33]</a> A table of the old and new adult daily values is provided at <a href="/wiki/Reference_Daily_Intake" title="Reference Daily Intake">Reference Daily Intake</a>. </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(6)"><h2 id="Sources">Sources</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=16" title="Edit section: Sources" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-6 collapsible-block" id="mf-section-6"> The <a href="/wiki/United_States_Department_of_Agriculture" title="United States Department of Agriculture">United States Department of Agriculture</a>, Agricultural Research Service maintains a food composition database from which riboflavin content in hundreds of foods can be searched.<a href="#cite_note-USDA-NDL-34">[34]</a> <table> <tbody><tr> <td valign="top"> <table class="wikitable"> <tbody><tr> <th>Source<a href="#cite_note-USDA-NDL-34">[34]</a> </th> <th>Amount (mg) (per 100 grams) </th></tr> <tr> <td><a href="/wiki/Beef" title="Beef">Beef</a> liver, pan-fried</td> <td>3.42 </td></tr> <tr> <td><a href="/wiki/Chicken" title="Chicken">Chicken</a> liver, pan-fried</td> <td>2.31 </td></tr> <tr> <td><a href="/wiki/Whey" title="Whey">Whey</a> protein powder</td> <td>2.02 </td></tr> <tr> <td><a href="/wiki/Salmon" title="Salmon">Salmon</a>, cooked, wild/farmed</td> <td>0.49/0.14 </td></tr> <tr> <td>Cows' <a href="/wiki/Milk" title="Milk">milk</a>, whole</td> <td>0.41 (one cup) </td></tr> <tr> <td><a href="/wiki/Turkey_bird" class="mw-redirect" title="Turkey bird">Turkey</a>, cooked, dark/breast</td> <td>0.38/0.21 </td></tr> <tr> <td><a href="/wiki/Pork" title="Pork">Pork</a>, cooked, chop</td> <td>0.23 </td></tr> <tr> <td><a href="/wiki/Egg_as_food" class="mw-redirect" title="Egg as food">Chicken eggs</a>, fried</td> <td>0.23 (one, large) </td></tr> <tr> <td><a href="/wiki/Chicken" title="Chicken">Chicken</a>, cooked, thigh/breast</td> <td>0.19/0.11 </td></tr> <tr> <td><a href="/wiki/Beef" title="Beef">Beef</a>, ground, cooked</td> <td>0.18 </td></tr></tbody></table> </td> <td valign="top"> <table class="wikitable"> <tbody><tr> <th>Source<a href="#cite_note-USDA-NDL-34">[34]</a> </th> <th>Amount (mg) (per 100 grams) </th></tr> <tr> <td><a href="/wiki/Cheese" title="Cheese">Cheese</a>, cheddar</td> <td>0.43 </td></tr> <tr> <td><a href="/wiki/Yogurt" title="Yogurt">Yogurt</a>, whole milk</td> <td>0.25 (one cup) </td></tr> <tr> <td><a href="/wiki/Almond" title="Almond">Almonds</a></td> <td>1.14 </td></tr> <tr> <td><a href="/wiki/Mushroom" title="Mushroom">Mushrooms</a>, white, raw</td> <td>0.40 </td></tr> <tr> <td><a href="/wiki/Spinach" title="Spinach">Spinach</a>, boiled</td> <td>0.24 </td></tr> <tr> <td><a href="/wiki/Bread" title="Bread">Bread</a>, baked, fortified</td> <td>0.25 </td></tr> <tr> <td><a href="/wiki/Pasta" title="Pasta">Pasta</a>, cooked, fortified</td> <td>0.14 </td></tr> <tr> <td><a href="/wiki/Grits" title="Grits">Corn grits</a></td> <td>0.06 </td></tr> <tr> <td><a href="/wiki/Rice" title="Rice">Rice</a>, cooked, brown/white</td> <td>0.05/0.00 </td></tr></tbody></table> </td> <td valign="top"> <table class="wikitable"> <tbody><tr> <th>Source<a href="#cite_note-USDA-NDL-34">[34]</a> </th> <th>Amount (mg) (per 100 grams) </th></tr> <tr> <td><a href="/wiki/Avocado" title="Avocado">Avocado</a></td> <td>0.14 </td></tr> <tr> <td><a href="/wiki/Kale" title="Kale">Kale</a>, boiled</td> <td>0.14 </td></tr> <tr> <td><a href="/wiki/Sweet_potato" title="Sweet potato">Sweet potato</a> baked</td> <td>0.11 </td></tr> <tr> <td><a href="/wiki/Peanut" title="Peanut">Peanuts</a>, roasted</td> <td>0.11 </td></tr> <tr> <td><a href="/wiki/Tofu" title="Tofu">Tofu</a>, firm</td> <td>0.10 </td></tr> <tr> <td><a href="/wiki/Bean" title="Bean">Beans</a>, green</td> <td>0.10 </td></tr> <tr> <td><a href="/wiki/Brussels_sprout" title="Brussels sprout">Brussels sprouts</a>, boiled</td> <td>0.08 </td></tr> <tr> <td><a href="/wiki/Romaine_lettuce" title="Romaine lettuce">Romaine lettuce</a></td> <td>0.07 </td></tr> <tr> <td><a href="/wiki/Potato" title="Potato">Potato</a>, baked, with skin</td> <td>0.05 </td></tr> <tr> <td><a href="/wiki/Bean" title="Bean">Beans</a>, baked</td> <td>0.04 </td></tr></tbody></table> </td></tr></tbody></table> The white <a href="/wiki/Flour" title="Flour">flour</a> produced after milling of wheat has only 67% of its original riboflavin amount left,<a href="#cite_note-35">[35]</a> so white flour is enriched in some countries.<a href="#cite_note-NutrientsAdded-36">[36]</a> Riboflavin is also added to ready-to-eat <a href="/wiki/Breakfast_cereal" title="Breakfast cereal">breakfast cereals</a>.<a href="#cite_note-Cereal-37">[37]</a> It is difficult to incorporate riboflavin into liquid products because it has poor solubility in water, hence the requirement for <a href="/wiki/Riboflavin-5%27-phosphate" class="mw-redirect" title="Riboflavin-5'-phosphate">riboflavin-5'-phosphate</a> (FMN, also called <a href="/wiki/E_number" title="E number">E101 when used as colorant</a>), a more soluble form of riboflavin.<a href="#cite_note-UKFSA-26">[26]</a> The enrichment of bread and ready-to-eat breakfast cereals contributes significantly to the dietary supply of the vitamin. Free riboflavin is naturally present in animal-sourced foods along with protein-bound FMN and FAD. Cows' milk contains mainly free riboflavin, but both FMN and FAD are present at low concentrations.<a href="#cite_note-38">[38]</a> <div class="mw-heading mw-heading3"><h3 id="Fortification">Fortification</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=17" title="Edit section: Fortification" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Some countries require or recommend fortification of grain foods.<a href="#cite_note-NutrientsAdded-36">[36]</a> As of 2024, 57 countries, mostly in North and South America and southeast Africa, require food fortification of <a href="/wiki/Wheat" title="Wheat">wheat</a> flour or <a href="/wiki/Maize" title="Maize">maize</a> (corn) flour with riboflavin or riboflavin-5'-phosphate sodium. The amounts stipulated range from 1.3 to 5.75 mg/kg.<a href="#cite_note-FortifMap-39">[39]</a> An additional 16 countries have a voluntary fortification program.<a href="#cite_note-FortifMap-39">[39]</a> For example, the Indian government recommends 4.0 mg/kg for <a href="/wiki/Maida_(flour)" title="Maida (flour)">"maida" (white)</a> and <a href="/wiki/Atta_flour" class="mw-redirect" title="Atta flour">"atta" (whole wheat)</a> flour.<a href="#cite_note-40">[40]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(7)"><h2 id="Absorption,_metabolism,_excretion">Absorption, metabolism, excretion</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=18" title="Edit section: Absorption, metabolism, excretion" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-7 collapsible-block" id="mf-section-7"> More than 90% of riboflavin in the diet is in the form of protein-bound FMN and FAD.<a href="#cite_note-ods-3">[3]</a> Exposure to <a href="/wiki/Gastric_acid" title="Gastric acid">gastric acid</a> in the stomach releases the coenzymes, which are subsequently enzymatically hydrolyzed in the proximal <a href="/wiki/Small_intestine" title="Small intestine">small intestine</a> to release free riboflavin.<a href="#cite_note-zempleni-41">[41]</a> Absorption occurs via a rapid <a href="/wiki/Active_transport" title="Active transport">active transport</a> system, with some additional <a href="/wiki/Passive_transport" title="Passive transport">passive diffusion</a> occurring at high concentrations.<a href="#cite_note-zempleni-41">[41]</a> Bile salts facilitate uptake, so absorption is improved when the vitamin is consumed with a meal.<a href="#cite_note-DRItext-4">[4]</a><a href="#cite_note-PKIN2020B2-5">[5]</a> The majority of newly absorbed riboflavin is taken up by the liver on the first pass, indicating that <a href="/wiki/Prandial" title="Prandial">postprandial</a> appearance of riboflavin in <a href="/wiki/Blood_plasma" title="Blood plasma">blood plasma</a> may underestimate absorption.<a href="#cite_note-PKIN2020B2-5">[5]</a> Three riboflavin transporter proteins have been identified: RFVT1 is present in the small intestine and also in the placenta; RFVT2 is highly expressed in brain and salivary glands; and RFVT3 is most highly expressed in the small intestine, testes, and prostate.<a href="#cite_note-PKIN2020B2-5">[5]</a><a href="#cite_note-Jaeger2016-42">[42]</a> Infants with mutations in the genes encoding these transport proteins can be treated with riboflavin administered orally.<a href="#cite_note-Jaeger2016-42">[42]</a> Riboflavin is reversibly converted to FMN and then FAD. From riboflavin to FMN is the function of zinc-requiring <a href="/wiki/Riboflavin_kinase" title="Riboflavin kinase">riboflavin kinase</a>; the reverse is accomplished by a phosphatase. From FMN to FAD is the function of magnesium-requiring FAD synthase; the reverse is accomplished by a <a href="/wiki/Pyrophosphatase" title="Pyrophosphatase">pyrophosphatase</a>. FAD appears to be an inhibitory end-product that down-regulates its own formation.<a href="#cite_note-PKIN2020B2-5">[5]</a> When excess riboflavin is absorbed by the small intestine, it is quickly removed from the blood and excreted in urine.<a href="#cite_note-PKIN2020B2-5">[5]</a> Urine color is used as a hydration status biomarker and, under normal conditions, correlates with <a href="/wiki/Urine_specific_gravity" title="Urine specific gravity">urine specific gravity</a> and <a href="/wiki/Urine_osmolality" title="Urine osmolality">urine osmolality</a>.<a href="#cite_note-43">[43]</a> However, riboflavin supplementation in large excess of requirements causes urine to appear more yellow than normal.<a href="#cite_note-MayoClinic-31">[31]</a> With normal dietary intake, about two-thirds of urinary output is riboflavin, the remainder having been partially metabolized to hydroxymethylriboflavin from oxidation within cells, and as other metabolites. When consumption exceeds the ability to absorb, riboflavin passes into the large intestine, where it is catabolized by bacteria to various metabolites that can be detected in <a href="/wiki/Feces" title="Feces">feces</a>.<a href="#cite_note-PKIN2020B2-5">[5]</a> There is speculation that unabsorbed riboflavin could affect the large intestine <a href="/wiki/Microbiome" title="Microbiome">microbiome</a>.<a href="#cite_note-44">[44]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(8)"><h2 id="Deficiency">Deficiency</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=19" title="Edit section: Deficiency" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-8 collapsible-block" id="mf-section-8"> <div class="mw-heading mw-heading3"><h3 id="Prevalence">Prevalence</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=20" title="Edit section: Prevalence" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Riboflavin deficiency is uncommon in the United States and in other countries with wheat flour or corn meal fortification programs.<a href="#cite_note-FortifMap-39">[39]</a> From data collected in biannual surveys of the U.S. population, for ages 20 and over, 22% of women and 19% of men reported consuming a supplement that contained riboflavin, typically a vitamin-mineral multi-supplement. For the non-supplement users, the dietary intake of adult women averaged 1.74 mg/day and men 2.44 mg/day. These amounts exceed the RDAs for riboflavin of 1.1 and 1.3 mg/day respectively.<a href="#cite_note-45">[45]</a> For all age groups, on average, consumption from food exceeded the RDAs.<a href="#cite_note-46">[46]</a> A 2001-02 U.S. survey reported that less than 3% of the population consumed less than the <a href="/wiki/Estimated_Average_Requirement" class="mw-redirect" title="Estimated Average Requirement">Estimated Average Requirement</a> of riboflavin.<a href="#cite_note-47">[47]</a> <div class="mw-heading mw-heading3"><h3 id="Signs_and_symptoms">Signs and symptoms</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=21" title="Edit section: Signs and symptoms" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Riboflavin deficiency (also called ariboflavinosis) results in <a href="/wiki/Stomatitis" title="Stomatitis">stomatitis</a>, symptoms of which include chapped and fissured lips, inflammation of the corners of the mouth (<a href="/wiki/Angular_cheilitis" title="Angular cheilitis">angular stomatitis</a>), sore throat, painful red tongue, and hair loss.<a href="#cite_note-ods-3">[3]</a> The eyes can become itchy, watery, bloodshot, and sensitive to light.<a href="#cite_note-ods-3">[3]</a> Riboflavin deficiency is associated with <a href="/wiki/Anemia" title="Anemia">anemia</a>.<a href="#cite_note-48">[48]</a> Prolonged riboflavin insufficiency may cause degeneration of the liver and nervous system.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-DRItext-4">[4]</a> Riboflavin deficiency may increase the risk of <a href="/wiki/Preeclampsia" class="mw-redirect" title="Preeclampsia">preeclampsia</a> in pregnant women.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-lpi-10">[10]</a> Deficiency of riboflavin during pregnancy can result in <a href="/wiki/Fetus" title="Fetus">fetal</a> <a href="/wiki/Birth_defect" title="Birth defect">birth defects</a>, including heart and limb deformities.<a href="#cite_note-49">[49]</a><a href="#cite_note-50">[50]</a> <div class="mw-heading mw-heading3"><h3 id="Risk_factors">Risk factors</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=22" title="Edit section: Risk factors" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> People at risk of having low riboflavin levels include <a href="/wiki/Alcoholism" title="Alcoholism">alcoholics</a>, <a href="/wiki/Vegetarianism" title="Vegetarianism">vegetarian</a> athletes, and practitioners of <a href="/wiki/Veganism" title="Veganism">veganism</a>.<a href="#cite_note-ods-3">[3]</a> Pregnant or lactating women and their infants may also be at risk, if the mother avoids meat and dairy products.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-lpi-10">[10]</a> <a href="/wiki/Anorexia" class="mw-redirect" title="Anorexia">Anorexia</a> and <a href="/wiki/Lactose_intolerance" title="Lactose intolerance">lactose intolerance</a> increase the risk of riboflavin deficiency.<a href="#cite_note-lpi-10">[10]</a> People with physically demanding lives, such as athletes and laborers, may require higher riboflavin intake.<a href="#cite_note-lpi-10">[10]</a> The conversion of riboflavin into FAD and FMN is impaired in people with <a href="/wiki/Hypothyroidism" title="Hypothyroidism">hypothyroidism</a>, <a href="/wiki/Adrenal_insufficiency" title="Adrenal insufficiency">adrenal insufficiency</a>, and riboflavin <a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">transporter</a> deficiency.<a href="#cite_note-lpi-10">[10]</a> <div class="mw-heading mw-heading3"><h3 id="Causes">Causes</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=23" title="Edit section: Causes" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> Riboflavin deficiency is usually found together with other nutrient deficiencies, particularly of other water-soluble <a href="/wiki/Vitamin" title="Vitamin">vitamins</a>.<a href="#cite_note-ods-3">[3]</a> A deficiency of riboflavin can be primary (i.e. caused by poor vitamin sources in the regular diet) or secondary, which may be a result of conditions that affect absorption in the intestine. Secondary deficiencies are typically caused by the body not being able to use the vitamin, or by an increased rate of excretion of the vitamin.<a href="#cite_note-lpi-10">[10]</a> Diet patterns that increase risk of deficiency include <a href="/wiki/Veganism" title="Veganism">veganism</a> and low-dairy <a href="/wiki/Vegetarianism" title="Vegetarianism">vegetarianism</a>.<a href="#cite_note-PKIN2020B2-5">[5]</a> Diseases such as cancer, <a href="/wiki/Heart_disease" class="mw-redirect" title="Heart disease">heart disease</a> and <a href="/wiki/Diabetes" title="Diabetes">diabetes</a> may cause or exacerbate riboflavin deficiency.<a href="#cite_note-DRItext-4">[4]</a> There are rare genetic defects that compromise riboflavin absorption, transport, metabolism or use by flavoproteins.<a href="#cite_note-Jaeger2016-42">[42]</a><a href="#cite_note-cali-51">[51]</a> One of these is riboflavin transporter deficiency, previously known as <a href="/wiki/Brown%E2%80%93Vialetto%E2%80%93Van_Laere_syndrome" title="Brown–Vialetto–Van Laere syndrome">Brown–Vialetto–Van Laere syndrome</a>.<a href="#cite_note-Jaeger2016-42">[42]</a><a href="#cite_note-cali-51">[51]</a> Variants of the genes SLC52A2 and <a href="/wiki/SLC52A3" title="SLC52A3">SLC52A3</a> which code for <a href="/wiki/Transport_protein" title="Transport protein">transporter proteins</a> RDVT2 and RDVT3, respectively, are defective.<a href="#cite_note-Jaeger2016-42">[42]</a><a href="#cite_note-cali-51">[51]</a> Infants and young children present with muscle weakness, <a href="/wiki/Cranial_nerve" class="mw-redirect" title="Cranial nerve">cranial nerve</a> deficits including hearing loss, sensory symptoms including sensory <a href="/wiki/Ataxia" title="Ataxia">ataxia</a>, feeding difficulties, and respiratory distress caused by a <a href="/wiki/Sensorimotor_network" title="Sensorimotor network">sensorimotor</a> <a href="/wiki/Axon" title="Axon">axonal</a> <a href="/wiki/Neuropathy" class="mw-redirect" title="Neuropathy">neuropathy</a> and cranial nerve pathology.<a href="#cite_note-cali-51">[51]</a> When untreated, infants with riboflavin transporter deficiency have labored breathing and are at risk of dying in the first decade of life. Treatment with oral supplementation of high amounts of riboflavin is lifesaving.<a href="#cite_note-Jaeger2016-42">[42]</a><a href="#cite_note-cali-51">[51]</a> Other inborn errors of metabolism include riboflavin-responsive multiple <a href="/wiki/Acyl-CoA_dehydrogenase" title="Acyl-CoA dehydrogenase">acyl-CoA dehydrogenase</a> deficiency, also known as a subset of <a href="/wiki/Glutaric_acidemia_type_2" title="Glutaric acidemia type 2">glutaric acidemia type 2</a>, and the C677T variant of the <a href="/wiki/Methylenetetrahydrofolate_reductase" title="Methylenetetrahydrofolate reductase">methylenetetrahydrofolate reductase</a> enzyme, which in adults has been associated with risk of high blood pressure.<a href="#cite_note-PKIN2020B2-5">[5]</a> <div class="mw-heading mw-heading3"><h3 id="Diagnosis_and_assessment">Diagnosis and assessment</h3> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=24" title="Edit section: Diagnosis and assessment" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div> The assessment of riboflavin status is essential for confirming cases with non-specific symptoms whenever deficiency is suspected. Total riboflavin excretion in healthy adults with normal riboflavin intake is about 120 <a href="/wiki/Microgram" title="Microgram">micrograms</a> per day, while excretion of less than 40 micrograms per day indicates deficiency.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-hoey-52">[52]</a> Riboflavin excretion rates decrease as a person ages, but increase during periods of <a href="/wiki/Chronic_stress" title="Chronic stress">chronic stress</a> and the use of some <a href="/wiki/Prescription_drugs" class="mw-redirect" title="Prescription drugs">prescription drugs</a>.<a href="#cite_note-ods-3">[3]</a> Indicators used in humans are <a href="/wiki/Erythrocyte" class="mw-redirect" title="Erythrocyte">erythrocyte</a> <a href="/wiki/Glutathione_reductase" title="Glutathione reductase">glutathione reductase</a> (EGR), erythrocyte flavin concentration and urinary excretion.<a href="#cite_note-DRItext-4">[4]</a><a href="#cite_note-PKIN2020B2-5">[5]</a> The erythrocyte glutathione reductase activity coefficient (EGRAC) provides a measure of tissue saturation and long-term riboflavin status.<a href="#cite_note-hoey-52">[52]</a><a href="#cite_note-ods-3">[3]</a> Results are expressed as an activity coefficient ratio, determined by enzyme activity with and without the addition of FAD to the culture medium. An EGRAC of 1.0 to 1.2 indicates that adequate amounts of riboflavin are present; 1.2 to 1.4 is considered low, greater than 1.4 indicates deficient.<a href="#cite_note-ods-3">[3]</a><a href="#cite_note-PKIN2020B2-5">[5]</a> For the less sensitive "erythrocyte flavin method", values greater than 400 nmol/L are considered adequate and values below 270 nmol/L are considered deficient.<a href="#cite_note-DRItext-4">[4]</a><a href="#cite_note-hoey-52">[52]</a> Urinary excretion is expressed as nmol of riboflavin per gram of <a href="/wiki/Creatinine" title="Creatinine">creatinine</a>. Low is defined as in the range of 50 to 72 nmol/g. Deficient is below 50 nmol/g. Urinary excretion load tests have been used to determine dietary requirements. For adult men, as oral doses were increased from 0.5 mg to 1.1 mg, there was a modest linear increase in urinary riboflavin, reaching 100 micrograms for a subsequent 24-hour urine collection.<a href="#cite_note-DRItext-4">[4]</a> Beyond a load dose of 1.1 mg, urinary excretion increased rapidly, so that with a dose of 2.5 mg, urinary output was 800 micrograms for a 24-hour urine collection.<a href="#cite_note-DRItext-4">[4]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(9)"><h2 id="History">History</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=25" title="Edit section: History" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-9 collapsible-block" id="mf-section-9"> The name "riboflavin" comes from "<a href="/wiki/Ribose" title="Ribose">ribose</a>" (the sugar whose <a href="/wiki/Reduction_(chemistry)" class="mw-redirect" title="Reduction (chemistry)">reduced</a> form, <a href="/wiki/Ribitol" title="Ribitol">ribitol</a>, forms part of its structure) and "<a href="/wiki/Flavin_group" title="Flavin group">flavin</a>", the ring-moiety that imparts the yellow color to the oxidized molecule (from Latin flavus, "yellow").<a href="#cite_note-PKIN2020B2-5">[5]</a> The reduced form, which occurs in metabolism along with the oxidized form, appears as orange-yellow needles or crystals.<a href="#cite_note-pubchem-8">[8]</a> The earliest reported identification, predating any concept of vitamins as essential nutrients, was by Alexander Wynter Blyth. In 1879, Blyth isolated a water-soluble component of cows' milk whey, which he named "lactochrome", that <a href="/wiki/Fluorescence" title="Fluorescence">fluoresced</a> yellow-green when exposed to light.<a href="#cite_note-anm-2">[2]</a> In the early 1900s, several research laboratories were investigating constituents of foods, essential to maintain growth in rats. These constituents were initially divided into fat-soluble "vitamine" A and water-soluble "vitamine" B. (The "e" was dropped in 1920.<a href="#cite_note-Rosenfeld-53">[53]</a>) Vitamin B was further thought to have two components, a heat-labile substance called B1 and a heat-stable substance called B2.<a href="#cite_note-anm-2">[2]</a> Vitamin B2 was tentatively identified to be the factor necessary for preventing <a href="/wiki/Pellagra" title="Pellagra">pellagra</a>, but that was later confirmed to be due to <a href="/wiki/Niacin_(nutrient)" class="mw-redirect" title="Niacin (nutrient)">niacin</a> (vitamin B3) deficiency. The confusion was due to the fact that riboflavin (B2) deficiency causes <a href="/wiki/Stomatitis" title="Stomatitis">stomatitis</a> symptoms similar to those seen in pellagra, but without the widespread peripheral skin lesions. For this reason, early in the history of identifying riboflavin deficiency in humans the condition was sometimes called "pellagra sine pellagra" (pellagra without pellagra).<a href="#cite_note-54">[54]</a> In 1935, <a href="/wiki/Paul_Gyorgy" title="Paul Gyorgy">Paul Gyorgy</a>, in collaboration with chemist <a href="/wiki/Richard_Kuhn" title="Richard Kuhn">Richard Kuhn</a> and physician T. Wagner-Jauregg, reported that rats kept on a B2-free diet were unable to gain weight.<a href="#cite_note-55">[55]</a> Isolation of B2 from yeast revealed the presence of a bright yellow-green fluorescent product that restored normal growth when fed to rats. The growth restored was directly proportional to the intensity of the fluorescence. This observation enabled the researchers to develop a rapid chemical bioassay in 1933, and then isolate the factor from egg white, calling it ovoflavin.<a href="#cite_note-anm-2">[2]</a> The same group then isolated the a similar preparation from whey and called it lactoflavin. In 1934, Kuhn's group identified the chemical structure of these flavins as identical, settled on "riboflavin" as a name, and were also able to synthesize the vitamin.<a href="#cite_note-anm-2">[2]</a> Circa 1937, riboflavin was also referred to as "Vitamin G".<a href="#cite_note-56">[56]</a> In 1938, Richard Kuhn was awarded the <a href="/wiki/Nobel_Prize_in_Chemistry" title="Nobel Prize in Chemistry">Nobel Prize in Chemistry</a> for his work on vitamins, which had included B2 and B6.<a href="#cite_note-57">[57]</a> In 1939, it was confirmed that riboflavin is essential for human health through a clinical trial conducted by William H. Sebrell and Roy E. Butler. Women fed a diet low in riboflavin developed stomatitis and other signs of deficiency, which were reversed when treated with synthetic riboflavin. The symptoms returned when the supplements were stopped.<a href="#cite_note-anm-2">[2]</a> </section><div class="mw-heading mw-heading2 section-heading" onclick="mfTempOpenSection(10)"><h2 id="References">References</h2> <a role="button" href="/w/index.php?title=Riboflavin&action=edit&section=26" title="Edit section: References" class="cdx-button cdx-button--size-large cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--icon-only cdx-button--weight-quiet "> edit </a> </div><section class="mf-section-10 collapsible-block" id="mf-section-10"> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-drugs-1">^ <a href="#cite_ref-drugs_1-0">a</a> <a href="#cite_ref-drugs_1-1">b</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/riboflavin.html">"Riboflavin"</a>. Drugs.com. 22 July 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20161230231848/https://www.drugs.com/monograph/riboflavin.html">Archived</a> from the original on 30 December 2016. Retrieved 8 October 2021.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Riboflavin&rft.date=2021-07-22&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmonograph%2Friboflavin.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARiboflavin" class="Z3988"> </li> <li id="cite_note-anm-2">^ <a href="#cite_ref-anm_2-0">a</a> <a href="#cite_ref-anm_2-1">b</a> <a href="#cite_ref-anm_2-2">c</a> <a href="#cite_ref-anm_2-3">d</a> <a href="#cite_ref-anm_2-4">e</a> <a href="#cite_ref-anm_2-5">f</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNorthrop-ClewesThurnham2012" class="citation journal cs1">Northrop-Clewes CA, Thurnham DI (2012). "The discovery and characterization of riboflavin". Annals of Nutrition & Metabolism. 61 (3): 224–30. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000343111">10.1159/000343111</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23183293">23183293</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7331172">7331172</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annals+of+Nutrition+%26+Metabolism&rft.atitle=The+discovery+and+characterization+of+riboflavin&rft.volume=61&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E224-%3C%2Fspan%3E30&rft.date=2012&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7331172%23id-name%3DS2CID&rft_id=info%3Apmid%2F23183293&rft_id=info%3Adoi%2F10.1159%2F000343111&rft.aulast=Northrop-Clewes&rft.aufirst=CA&rft.au=Thurnham%2C+DI&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARiboflavin" class="Z3988"> </li> <li id="cite_note-ods-3">^ <a href="#cite_ref-ods_3-0">a</a> <a href="#cite_ref-ods_3-1">b</a> <a href="#cite_ref-ods_3-2">c</a> <a href="#cite_ref-ods_3-3">d</a> <a href="#cite_ref-ods_3-4">e</a> <a href="#cite_ref-ods_3-5">f</a> <a href="#cite_ref-ods_3-6">g</a> <a href="#cite_ref-ods_3-7">h</a> <a href="#cite_ref-ods_3-8">i</a> <a href="#cite_ref-ods_3-9">j</a> <a href="#cite_ref-ods_3-10">k</a> <a href="#cite_ref-ods_3-11">l</a> <a href="#cite_ref-ods_3-12">m</a> <a href="#cite_ref-ods_3-13">n</a> <a href="#cite_ref-ods_3-14">o</a> <a href="#cite_ref-ods_3-15">p</a> <a href="#cite_ref-ods_3-16">q</a> <a href="#cite_ref-ods_3-17">r</a> <a href="#cite_ref-ods_3-18">s</a> <a href="#cite_ref-ods_3-19">t</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/">"Riboflavin: Fact Sheet for Health Professionals"</a>. 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href="/w/index.php?title=Riboflavin&action=history"> <div class="post-content last-modified-bar__content"> Last edited on 12 January 2025, at 02:11 </div> </a> <div class="post-content footer-content"> <div id='mw-data-after-content'> <div class="read-more-container"></div> </div> <div id="p-lang"> <h4>Languages</h4> <section> <ul id="p-variants" class="minerva-languages"></ul> <ul class="minerva-languages"><li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Riboflavien" title="Riboflavien – Afrikaans" lang="af" hreflang="af" data-title="Riboflavien" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target">Afrikaans</a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%81%D9%8A%D8%AA%D8%A7%D9%85%D9%8A%D9%86_%D8%A82" title="فيتامين ب2 – Arabic" lang="ar" hreflang="ar" data-title="فيتامين ب2" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Vitamina_B2" title="Vitamina B2 – Asturian" lang="ast" hreflang="ast" data-title="Vitamina B2" data-language-autonym="Asturianu" data-language-local-name="Asturian" class="interlanguage-link-target">Asturianu</a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%B0%E0%A6%BF%E0%A6%AC%E0%A7%8B%E0%A6%AB%E0%A7%8D%E0%A6%B2%E0%A6%BE%E0%A6%AD%E0%A6%BF%E0%A6%A8" title="রিবোফ্লাভিন – Bangla" lang="bn" hreflang="bn" data-title="রিবোফ্লাভিন" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target">বাংলা</a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%A0%D1%8B%D0%B1%D0%B0%D1%84%D0%BB%D0%B0%D0%B2%D1%96%D0%BD" title="Рыбафлавін – Belarusian" lang="be" hreflang="be" data-title="Рыбафлавін" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target">Беларуская</a></li><li class="interlanguage-link interwiki-be-x-old mw-list-item"><a href="https://be-tarask.wikipedia.org/wiki/%D0%A0%D1%8B%D0%B1%D0%B0%D1%84%D0%BB%D1%8F%D0%B2%D1%96%D0%BD" title="Рыбафлявін – Belarusian (Taraškievica orthography)" lang="be-tarask" hreflang="be-tarask" data-title="Рыбафлявін" data-language-autonym="Беларуская (тарашкевіца)" data-language-local-name="Belarusian (Taraškievica orthography)" class="interlanguage-link-target">Беларуская (тарашкевіца)</a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%92%D0%B8%D1%82%D0%B0%D0%BC%D0%B8%D0%BD_B2" title="Витамин B2 – Bulgarian" lang="bg" hreflang="bg" data-title="Витамин B2" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target">Български</a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Vitamin_B2" title="Vitamin B2 – Bosnian" lang="bs" hreflang="bs" data-title="Vitamin B2" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target">Bosanski</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Riboflavina" title="Riboflavina – Catalan" lang="ca" hreflang="ca" data-title="Riboflavina" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Vitam%C3%ADn_B2" title="Vitamín B2 – Czech" lang="cs" hreflang="cs" data-title="Vitamín B2" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Ribofflafin" title="Ribofflafin – Welsh" lang="cy" hreflang="cy" data-title="Ribofflafin" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target">Cymraeg</a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Danish" lang="da" hreflang="da" data-title="Riboflavin" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target">Dansk</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Riboflavin" title="Riboflavin – German" lang="de" hreflang="de" data-title="Riboflavin" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-dv mw-list-item"><a href="https://dv.wikipedia.org/wiki/%DE%88%DE%A8%DE%93%DE%A6%DE%89%DE%A8%DE%82%DE%B0_%DE%84%DE%A92" title="ވިޓަމިން ބީ2 – Divehi" lang="dv" hreflang="dv" data-title="ވިޓަމިން ބީ2" data-language-autonym="ދިވެހިބަސް" data-language-local-name="Divehi" class="interlanguage-link-target">ދިވެހިބަސް</a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/B2-vitamiin" title="B2-vitamiin – Estonian" lang="et" hreflang="et" data-title="B2-vitamiin" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target">Eesti</a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A1%CE%B9%CE%B2%CE%BF%CF%86%CE%BB%CE%B1%CE%B2%CE%AF%CE%BD%CE%B7" title="Ριβοφλαβίνη – Greek" lang="el" hreflang="el" data-title="Ριβοφλαβίνη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target">Ελληνικά</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Vitamina_B2" title="Vitamina B2 – Spanish" lang="es" hreflang="es" data-title="Vitamina B2" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Riboflavino" title="Riboflavino – Esperanto" lang="eo" hreflang="eo" data-title="Riboflavino" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target">Esperanto</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/B2_bitamina" title="B2 bitamina – Basque" lang="eu" hreflang="eu" data-title="B2 bitamina" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%88%DB%8C%D8%AA%D8%A7%D9%85%DB%8C%D9%86_%D8%A8%DB%B2" title="ویتامین ب۲ – Persian" lang="fa" hreflang="fa" data-title="ویتامین ب۲" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fo mw-list-item"><a href="https://fo.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Faroese" lang="fo" hreflang="fo" data-title="Riboflavin" data-language-autonym="Føroyskt" data-language-local-name="Faroese" class="interlanguage-link-target">Føroyskt</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Riboflavine" title="Riboflavine – French" lang="fr" hreflang="fr" data-title="Riboflavine" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Ribeaflaivin" title="Ribeaflaivin – Irish" lang="ga" hreflang="ga" data-title="Ribeaflaivin" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target">Gaeilge</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Vitamina_B2" title="Vitamina B2 – Galician" lang="gl" hreflang="gl" data-title="Vitamina B2" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%A6%AC%EB%B3%B4%ED%94%8C%EB%9D%BC%EB%B9%88" title="리보플라빈 – Korean" lang="ko" hreflang="ko" data-title="리보플라빈" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8E%D5%AB%D5%BF%D5%A1%D5%B4%D5%AB%D5%B6_B2" title="Վիտամին B2 – Armenian" lang="hy" hreflang="hy" data-title="Վիտամին B2" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target">Հայերեն</a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B0%E0%A4%BF%E0%A4%AC%E0%A5%8B%E0%A4%AB%E0%A5%8D%E0%A4%B2%E0%A5%87%E0%A4%B5%E0%A4%BF%E0%A4%A8" title="रिबोफ्लेविन – Hindi" lang="hi" hreflang="hi" data-title="रिबोफ्लेविन" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target">हिन्दी</a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Vitamin_B2" title="Vitamin B2 – Croatian" lang="hr" hreflang="hr" data-title="Vitamin B2" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target">Hrvatski</a></li><li class="interlanguage-link interwiki-io mw-list-item"><a href="https://io.wikipedia.org/wiki/Riboflavino" title="Riboflavino – Ido" lang="io" hreflang="io" data-title="Riboflavino" data-language-autonym="Ido" data-language-local-name="Ido" class="interlanguage-link-target">Ido</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Indonesian" lang="id" hreflang="id" data-title="Riboflavin" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Riboflavina" title="Riboflavina – Italian" lang="it" hreflang="it" data-title="Riboflavina" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%95%D7%99%D7%98%D7%9E%D7%99%D7%9F_B2" title="ויטמין B2 – Hebrew" lang="he" hreflang="he" data-title="ויטמין B2" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD" title="Рибофлавин – Kazakh" lang="kk" hreflang="kk" data-title="Рибофлавин" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target">Қазақша</a></li><li class="interlanguage-link interwiki-rw mw-list-item"><a href="https://rw.wikipedia.org/wiki/Vitamini_B2" title="Vitamini B2 – Kinyarwanda" lang="rw" hreflang="rw" data-title="Vitamini B2" data-language-autonym="Ikinyarwanda" data-language-local-name="Kinyarwanda" class="interlanguage-link-target">Ikinyarwanda</a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD" title="Рибофлавин – Kyrgyz" lang="ky" hreflang="ky" data-title="Рибофлавин" data-language-autonym="Кыргызча" data-language-local-name="Kyrgyz" class="interlanguage-link-target">Кыргызча</a></li><li class="interlanguage-link interwiki-lo mw-list-item"><a href="https://lo.wikipedia.org/wiki/%E0%BA%A7%E0%BA%B4%E0%BA%95%E0%BA%B2%E0%BA%A1%E0%BA%B4%E0%BA%99%E0%BA%9A%E0%BA%B52" title="ວິຕາມິນບີ2 – Lao" lang="lo" hreflang="lo" data-title="ວິຕາມິນບີ2" data-language-autonym="ລາວ" data-language-local-name="Lao" class="interlanguage-link-target">ລາວ</a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/B2_vitam%C4%ABns" title="B2 vitamīns – Latvian" lang="lv" hreflang="lv" data-title="B2 vitamīns" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target">Latviešu</a></li><li class="interlanguage-link interwiki-lb mw-list-item"><a href="https://lb.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Luxembourgish" lang="lb" hreflang="lb" data-title="Riboflavin" data-language-autonym="Lëtzebuergesch" data-language-local-name="Luxembourgish" class="interlanguage-link-target">Lëtzebuergesch</a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Riboflavinas" title="Riboflavinas – Lithuanian" lang="lt" hreflang="lt" data-title="Riboflavinas" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target">Lietuvių</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Hungarian" lang="hu" hreflang="hu" data-title="Riboflavin" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD" title="Рибофлавин – Macedonian" lang="mk" hreflang="mk" data-title="Рибофлавин" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target">Македонски</a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%B1%E0%B5%88%E0%B4%AC%E0%B5%8B%E0%B4%AB%E0%B5%8D%E0%B4%B2%E0%B5%87%E0%B4%B5%E0%B4%BF%E0%B5%BB" title="റൈബോഫ്ലേവിൻ – Malayalam" lang="ml" hreflang="ml" data-title="റൈബോഫ്ലേവിൻ" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target">മലയാളം</a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Vitamin_B2" title="Vitamin B2 – Malay" lang="ms" hreflang="ms" data-title="Vitamin B2" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target">Bahasa Melayu</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Riboflavine" title="Riboflavine – Dutch" lang="nl" hreflang="nl" data-title="Riboflavine" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%AA%E3%83%9C%E3%83%95%E3%83%A9%E3%83%93%E3%83%B3" title="リボフラビン – Japanese" lang="ja" hreflang="ja" data-title="リボフラビン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Riboflavin" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target">Norsk bokmål</a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Vitamina_B2" title="Vitamina B2 – Occitan" lang="oc" hreflang="oc" data-title="Vitamina B2" data-language-autonym="Occitan" data-language-local-name="Occitan" class="interlanguage-link-target">Occitan</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B0%E0%AC%BE%E0%AC%87%E0%AC%AC%E0%AD%8B%E0%AC%AB%E0%AD%8D%E0%AC%B2%E0%AC%BE%E0%AC%AD%E0%AC%BF%E0%AC%A8" title="ରାଇବୋଫ୍ଲାଭିନ – Odia" lang="or" hreflang="or" data-title="ରାଇବୋଫ୍ଲାଭିନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Uzbek" lang="uz" hreflang="uz" data-title="Riboflavin" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target">Oʻzbekcha / ўзбекча</a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Witamina_B2" title="Witamina B2 – Polish" lang="pl" hreflang="pl" data-title="Witamina B2" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Riboflavina" title="Riboflavina – Portuguese" lang="pt" hreflang="pt" data-title="Riboflavina" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Riboflavin%C4%83" title="Riboflavină – Romanian" lang="ro" hreflang="ro" data-title="Riboflavină" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD" title="Рибофлавин – Russian" lang="ru" hreflang="ru" data-title="Рибофлавин" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-sah mw-list-item"><a href="https://sah.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD_%D0%922" title="Рибофлавин В2 – Yakut" lang="sah" hreflang="sah" data-title="Рибофлавин В2" data-language-autonym="Саха тыла" data-language-local-name="Yakut" class="interlanguage-link-target">Саха тыла</a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Scots" lang="sco" hreflang="sco" data-title="Riboflavin" data-language-autonym="Scots" data-language-local-name="Scots" class="interlanguage-link-target">Scots</a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/Vitamina_B2" title="Vitamina B2 – Albanian" lang="sq" hreflang="sq" data-title="Vitamina B2" data-language-autonym="Shqip" data-language-local-name="Albanian" class="interlanguage-link-target">Shqip</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Simple English" lang="en-simple" hreflang="en-simple" data-title="Riboflavin" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Riboflav%C3%ADn" title="Riboflavín – Slovak" lang="sk" hreflang="sk" data-title="Riboflavín" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target">Slovenčina</a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Slovenian" lang="sl" hreflang="sl" data-title="Riboflavin" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target">Slovenščina</a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%DA%A4%DB%8C%D8%AA%D8%A7%D9%85%DB%8C%D9%86_%D8%A8%DB%8C_%D9%A2" title="ڤیتامین بی ٢ – Central Kurdish" lang="ckb" hreflang="ckb" data-title="ڤیتامین بی ٢" data-language-autonym="کوردی" data-language-local-name="Central Kurdish" class="interlanguage-link-target">کوردی</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%92%D0%B8%D1%82%D0%B0%D0%BC%D0%B8%D0%BD_%D0%912" title="Витамин Б2 – Serbian" lang="sr" hreflang="sr" data-title="Витамин Б2" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Vitamin_B2" title="Vitamin B2 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Vitamin B2" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Sundanese" lang="su" hreflang="su" data-title="Riboflavin" data-language-autonym="Sunda" data-language-local-name="Sundanese" class="interlanguage-link-target">Sunda</a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Riboflaviini" title="Riboflaviini – Finnish" lang="fi" hreflang="fi" data-title="Riboflaviini" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target">Suomi</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Swedish" lang="sv" hreflang="sv" data-title="Riboflavin" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%B0%E0%AE%BF%E0%AE%AA%E0%AF%8B%E0%AE%83%E0%AE%AA%E0%AE%BF%E0%AE%B3%E0%AE%BE%E0%AE%B5%E0%AE%BF%E0%AE%A9%E0%AF%8D" title="ரிபோஃபிளாவின் – Tamil" lang="ta" hreflang="ta" data-title="ரிபோஃபிளாவின்" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target">தமிழ்</a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%84%E0%B8%A3%E0%B9%82%E0%B8%9A%E0%B9%80%E0%B8%9F%E0%B8%A5%E0%B8%A7%E0%B8%B4%E0%B8%99" title="ไรโบเฟลวิน – Thai" lang="th" hreflang="th" data-title="ไรโบเฟลวิน" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target">ไทย</a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D0%B8%D0%BD" title="Рибофлавин – Tajik" lang="tg" hreflang="tg" data-title="Рибофлавин" data-language-autonym="Тоҷикӣ" data-language-local-name="Tajik" class="interlanguage-link-target">Тоҷикӣ</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Turkish" lang="tr" hreflang="tr" data-title="Riboflavin" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-tyv mw-list-item"><a href="https://tyv.wikipedia.org/wiki/%D0%92%D0%B8%D1%82%D0%B0%D0%BC%D0%B8%D0%BD_%D0%922" title="Витамин В2 – Tuvinian" lang="tyv" hreflang="tyv" data-title="Витамин В2" data-language-autonym="Тыва дыл" data-language-local-name="Tuvinian" class="interlanguage-link-target">Тыва дыл</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A0%D0%B8%D0%B1%D0%BE%D1%84%D0%BB%D0%B0%D0%B2%D1%96%D0%BD" title="Рибофлавін – Ukrainian" lang="uk" hreflang="uk" data-title="Рибофлавін" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Riboflavin" title="Riboflavin – Vietnamese" lang="vi" hreflang="vi" data-title="Riboflavin" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-wa mw-list-item"><a href="https://wa.wikipedia.org/wiki/Riboflavene" title="Riboflavene – Walloon" lang="wa" hreflang="wa" data-title="Riboflavene" data-language-autonym="Walon" data-language-local-name="Walloon" class="interlanguage-link-target">Walon</a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E6%A0%B8%E9%BB%84%E7%B4%A0" title="核黄素 – Wu" lang="wuu" hreflang="wuu" data-title="核黄素" data-language-autonym="吴语" data-language-local-name="Wu" class="interlanguage-link-target">吴语</a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E7%B6%AD%E4%BB%96%E5%91%BDB2" title="維他命B2 – Cantonese" lang="yue" hreflang="yue" data-title="維他命B2" data-language-autonym="粵語" data-language-local-name="Cantonese" class="interlanguage-link-target">粵語</a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E6%A0%B8%E9%BB%84%E7%B4%A0" title="核黄素 – Chinese" lang="zh" hreflang="zh" data-title="核黄素" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target">中文</a></li></ul> </section> </div> <div class="minerva-footer-logo"> <img src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" alt="Wikipedia" width="120" 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