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Strong research professional graduated from Tribhuvan University. Over 100 publications (peer review  non-peer, freelance) and impact factor 100. Also a computer geek with some programming skill.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://tiet.academia.edu/SanjaiSaxena"><img class="profile-avatar u-positionAbsolute" alt="Sanjai Saxena" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/66522/18696/17377/s200_sanjai.saxena.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" 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/></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://unibe-ch2.academia.edu/ADommann">Alex Dommann</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Bern</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="158582682" href="https://www.academia.edu/Documents/in/Biotechnology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://cpds-tu.academia.edu/BishnuMarasini","location":"/BishnuMarasini","scheme":"https","host":"cpds-tu.academia.edu","port":null,"pathname":"/BishnuMarasini","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biotechnology"]}" data-trace="false" data-dom-id="Pill-react-component-62be2456-791e-4e3c-a9d0-c6664affe16d"></div> <div id="Pill-react-component-62be2456-791e-4e3c-a9d0-c6664affe16d"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="nav-container backbone-profile-documents-nav hidden-xs"><ul class="nav-tablist" role="tablist"><li class="nav-chip active" role="presentation"><a data-section-name="" data-toggle="tab" href="#all" role="tab">all</a></li><li class="nav-chip" role="presentation"><a class="js-profile-docs-nav-section u-textTruncate" data-click-track="profile-works-tab" data-section-name="Papers" data-toggle="tab" href="#papers" role="tab" title="Papers"><span>75</span> <span class="ds2-5-body-sm-bold">Papers</span></a></li><li class="nav-chip" role="presentation"><a class="js-profile-docs-nav-section u-textTruncate" data-click-track="profile-works-tab" data-section-name="articles" data-toggle="tab" href="#articles" role="tab" title="articles"><span>11</span> <span class="ds2-5-body-sm-bold">articles</span></a></li></ul></div><div class="divider ds-divider-16" style="margin: 0px;"></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Bishnu P Marasini</h3></div><div class="js-work-strip profile--work_container" data-work-id="114701539"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers"><img alt="Research paper thumbnail of Cytotoxic Activity of Alkaloids Isolated from <i>Stephania glandulifera</i> Miers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers">Cytotoxic Activity of Alkaloids Isolated from <i>Stephania glandulifera</i> Miers</a></div><div class="wp-workCard_item"><span>Journal of biologically active products from nature</span><span>, Mar 4, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701539"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701539"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701539; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701539]").text(description); $(".js-view-count[data-work-id=114701539]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701539; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701539']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701539]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701539,"title":"Cytotoxic Activity of Alkaloids Isolated from \u003ci\u003eStephania glandulifera\u003c/i\u003e Miers","internal_url":"https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701538/Smartphone_operated_affordable_PCR_thermal_cycler_for_the_detection_of_antimicrobial_resistant_bacterial_genes"><img alt="Research paper thumbnail of Smartphone-operated affordable PCR thermal cycler for the detection of antimicrobial resistant bacterial genes" class="work-thumbnail" src="https://attachments.academia-assets.com/111327559/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701538/Smartphone_operated_affordable_PCR_thermal_cycler_for_the_detection_of_antimicrobial_resistant_bacterial_genes">Smartphone-operated affordable PCR thermal cycler for the detection of antimicrobial resistant bacterial genes</a></div><div class="wp-workCard_item"><span>PLOS global public health</span><span>, Feb 27, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Antimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires aff...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Antimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires affordable, rapid, and user-friendly diagnostic methods. Our aim was to develop a low-cost thermocycler to perform polymerase chain reaction (PCR). We developed a smartphoneoperated PCR thermal cycler using locally available recycled materials. The thermal cycler was used for the amplification for three bacterial genes-bla-TEM, bla-CTXM and 16s rRNA in human urine samples. The performance of custom-built thermal cycler was compared with commercial thermal cycler. The thermal cycler was portable (<1kg weight), required 12 V power supply, 25 μL of solution, and cost only USD50.0. Temperature and time conditions were instructed using a custom-built smartphone application. The ramping rate of was 0.23˚C for heating and 0.43˚C for cooling. The reported temperatures were within ± 0.5˚C of set temperature. The human urine samples were highly resistance and multi-resistant. Nearly 46% (n = 54) E. coli isolates were positive in ESBL screening test. The custom-built thermocycler was able to accurately predict the presence of bla-TEM, bla-CTXM genes, and 16s rRNA (n = 6). We developed and demonstrated a portable, low-cost, easy-to-use, and smartphone-operated PCR thermal cycler. Since it is portable, it can be used in remote location and field settings, including places without stable power supply. The use of the thermal cycler system can be extended, beyond the detection of AMR genes, e.g., in clinical diagnosis, genetics, forensic analysis, and environmental protection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3b6e340bc27796814ea51fdee99254bf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327559,"asset_id":114701538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327559/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701538; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701537"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701537/Vaccines_and_the_role_of_the_immune_system_An_approach_in_decreasing_COVID_19_mortality"><img alt="Research paper thumbnail of Vaccines and the role of the immune system: An approach in decreasing COVID -19 mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/111327565/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701537/Vaccines_and_the_role_of_the_immune_system_An_approach_in_decreasing_COVID_19_mortality">Vaccines and the role of the immune system: An approach in decreasing COVID -19 mortality</a></div><div class="wp-workCard_item"><span>International Journal of medicine and bi-medical sciences</span><span>, Dec 29, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8c4e03bd038684bd9c8c7499508423c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327565,"asset_id":114701537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327565/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701537; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701536/Synthesis_and_Characterization_of_High_Molecular_Weight_Chitosan_and_Antioxidant_Activity_of_Its_Chitosan_Oligosaccharide_Encapsulation"><img alt="Research paper thumbnail of Synthesis and Characterization of High Molecular Weight Chitosan, and Antioxidant Activity of Its Chitosan Oligosaccharide Encapsulation" class="work-thumbnail" src="https://attachments.academia-assets.com/111327557/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701536/Synthesis_and_Characterization_of_High_Molecular_Weight_Chitosan_and_Antioxidant_Activity_of_Its_Chitosan_Oligosaccharide_Encapsulation">Synthesis and Characterization of High Molecular Weight Chitosan, and Antioxidant Activity of Its Chitosan Oligosaccharide Encapsulation</a></div><div class="wp-workCard_item"><span>Journal of Nepal Chemical Society</span><span>, Mar 1, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High molecular weight nanocrystalline chitosan (HMWNC) with M w of 350 kDa and 66.92% DDA was pre...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High molecular weight nanocrystalline chitosan (HMWNC) with M w of 350 kDa and 66.92% DDA was prepared by alkaline N-deacetylation of chitin that was abundantly obtained after demineralization and deproteinization of pulverized crab shells, and commercially available chitosan oligosaccharide (COS) with average M w < 3000 Da and 87% DDA was encapsulated with HMWNC. The encapsulation of COS as a pharmaceutical ingredient into HMWC was hypothesized to enhance the bioavailability of COS in target cells. The HMWNC encapsulated chitosan oligosaccharide (COS-HMWNC) showed in vitro antioxidant activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC 50 = 512.6±14.4 μg/mL) while others showed less than 50% inhibition at 1000 μg/mL. The lower the molecular weight of chitosan, the higher was the antioxidant activity. The study showed that the encapsulation of COS molecules in HMWNC could be used as a simple and effective way of enhancing the antioxidant activity of COS.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6f38201d3af1a59fc4500e0a0ba4957e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327557,"asset_id":114701536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327557/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701536; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701535"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701535/Synthesis_and_enzyme_inhibitory_activities_of_some_new_pyrazole_based_heterocyclic_compounds"><img alt="Research paper thumbnail of Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701535/Synthesis_and_enzyme_inhibitory_activities_of_some_new_pyrazole_based_heterocyclic_compounds">Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds</a></div><div class="wp-workCard_item"><span>Medicinal Chemistry Research</span><span>, Oct 21, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Three tridentate N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (2),...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Three tridentate N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (2), N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-cyclohexylamine (3) and 2-[bis (1, 5-dimethyl-1H-pyrazol-3-ylmethyl) amino] ethan-1-ol (4) are synthesized and ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701535"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701535"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701535; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers"><img alt="Research paper thumbnail of Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers">Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers</a></div><div class="wp-workCard_item"><span>Journal of Biologically Active Products from Nature</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701533; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701533]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701533,"title":"Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers","internal_url":"https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701532"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701532/Global_regional_and_national_prevalence_and_mortality_burden_of_sickle_cell_disease_2000_2021_a_systematic_analysis_from_the_Global_Burden_of_Disease_Study_2021"><img alt="Research paper thumbnail of Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701532/Global_regional_and_national_prevalence_and_mortality_burden_of_sickle_cell_disease_2000_2021_a_systematic_analysis_from_the_Global_Burden_of_Disease_Study_2021">Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021</a></div><div class="wp-workCard_item"><span>The Lancet Haematology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Previous global analyses, with known underdiagnosis and single cause per death attribu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. Methods We estimated cause-specific sickle cell disease mortality using standardised GBD approaches, in which each death is assigned to a single underlying cause, to estimate mortality rates from the International Classification of Diseases (ICD)-coded vital registration, surveillance, and verbal autopsy data. In parallel, our goal was to estimate a more accurate account of sickle cell disease health burden using four types of epidemiological data on sickle cell disease: birth incidence, age-specific prevalence, with-condition mortality (total deaths), and excess mortality (excess deaths). Systematic reviews, supplemented with ICD-coded hospital discharge and insurance claims data, informed this modelling approach. We employed DisMod-MR 2.1 to triangulate between these measures-borrowing strength from predictive covariates and across age, time, and geography-and generated internally consistent estimates of incidence, prevalence, and mortality for three distinct genotypes of sickle cell disease: homozygous sickle cell disease and severe sickle cell β-thalassaemia, sickle-haemoglobin C disease, and mild sickle cell β-thalassaemia. Summing the three models yielded final estimates of incidence at birth, prevalence by age and sex, and total sickle cell disease mortality, the latter of which was compared directly against cause-specific mortality estimates to evaluate differences in mortality burden assessment and implications for the Sustainable Development Goals (SDGs). Findings Between 2000 and 2021, national incidence rates of sickle cell disease were relatively stable, but total births of babies with sickle cell disease increased globally by 13•7% (95% uncertainty interval 11•1-16•5), to 515 000 (425 000-614 000), primarily due to population growth in the Caribbean and western and central sub-Saharan Africa. The number of people living with sickle cell disease globally increased by 41•4% (38•3-44•9), from 5•46 million (4•62-6•45) in 2000 to 7•74 million (6•51-9•2) in 2021. We estimated 34 400 (25 000-45 200) cause-specific all-age deaths globally in 2021, but total sickle cell disease mortality burden was nearly 11-times higher at 376 000 (303 000-467 000). In children younger than 5 years, there were 81 100 (58 800-108 000) deaths, ranking total sickle cell disease mortality as 12th (compared to 40th for cause-specific sickle cell disease mortality) across all causes estimated by the GBD in 2021. Interpretation Our findings show a strikingly high contribution of sickle cell disease to all-cause mortality that is not apparent when each death is assigned to only a single cause. Sickle cell disease mortality burden is highest in children, especially in countries with the greatest under-5 mortality rates. Without comprehensive strategies to address morbidity and mortality associated with sickle cell disease, attainment of SDG 3.1, 3.2, and 3.4 is uncertain. Widespread data gaps and correspondingly high uncertainty in the estimates highlight the urgent need for routine and sustained surveillance efforts, further research to assess the contribution of conditions associated with sickle cell disease, and widespread deployment of evidence-based prevention and treatment for those with sickle cell disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701532"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701532"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701532; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701532]").text(description); $(".js-view-count[data-work-id=114701532]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701532; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701532']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701532]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701532,"title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021","internal_url":"https://www.academia.edu/114701532/Global_regional_and_national_prevalence_and_mortality_burden_of_sickle_cell_disease_2000_2021_a_systematic_analysis_from_the_Global_Burden_of_Disease_Study_2021","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701531"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review"><img alt="Research paper thumbnail of Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review">Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review</a></div><div class="wp-workCard_item"><span>Microbiology Insights</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Antimicrobial resistance (AMR) is increasing and it is a serious public health problem worldwide....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Antimicrobial resistance (AMR) is increasing and it is a serious public health problem worldwide. Nepal is considered as one of the contributors for rising AMR due to the most prevalent irrational use of antibiotics. In this review, we have assessed the practices of antibiotic prescription and dispensing, and antibiotic resistance of commonly encountered bacteria in Nepal. There is exponential increase of therapeutic consumption of antibiotics either without clinician’s prescription or irrational prescription. Almost half of the population in Nepal was found to purchase antibiotics easily from the nearby pharmacies without clinician’s prescription. Irrational prescription is exceeded in remote areas which could be due to lack of access with health posts and hospitals. The third generation cephalosporins, which are considered as the last resort antibiotics were found to be relatively prescribed and dispensed higher as compared to other classes of antibiotics. Despite the existing lim...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701531"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701531"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701531; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701531]").text(description); $(".js-view-count[data-work-id=114701531]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701531; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701531']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701531]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701531,"title":"Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review","internal_url":"https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701530"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701530/Oxovanadium_IV_Complexes_with_Triazole_Based_Schiff_Base_Ligands_Synthesis_Characterization_and_Antibacterial_Study"><img alt="Research paper thumbnail of Oxovanadium(IV) Complexes with Triazole Based Schiff Base Ligands: Synthesis, Characterization and Antibacterial Study" class="work-thumbnail" src="https://attachments.academia-assets.com/111327553/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701530/Oxovanadium_IV_Complexes_with_Triazole_Based_Schiff_Base_Ligands_Synthesis_Characterization_and_Antibacterial_Study">Oxovanadium(IV) Complexes with Triazole Based Schiff Base Ligands: Synthesis, Characterization and Antibacterial Study</a></div><div class="wp-workCard_item"><span>Journal of Nepal Chemical Society</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Schiff bases have been synthesized by the reaction of triazole containing primary amine with arom...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Schiff bases have been synthesized by the reaction of triazole containing primary amine with aromatic carbonyl compounds. The Schiff bases prepared, act as ligand when these are made in contact with oxovanadium (VO2+) ion. Some new mononuclear oxovanadium(IV) complexes have been synthesized by the reaction of Schiff base ligands with vanadyl sulphate (VOSO4.xH2O) and the complexes are analyzed by different spectroscopic methods; [fourier-transform infrared (FTIR), ultraviolet-visible (UV-Vis.), electron paramagnetic resonance (EPR)], X-ray diffraction (XRD) analysis, elemental analysis, and conductivity measurement. The complexes have been well characterized based on analytical data. The electrolytic nature of the complexes was determined based on the molar conductance values. The powder XRD pattern has been used to determine crystal size and type. The synthesized Schiff base ligands and oxovanadium(IV) complexes were found to be stable in air and moisture at room temperature. On t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="107d4417fb8c215d3db507d36127e3e2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327553,"asset_id":114701530,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327553/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701530"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701530"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701530; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701529"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701529/Triazole_based_Schiff_bases_and_their_oxovanadium_IV_complexes_Synthesis_characterization_antibacterial_assay_and_computational_assessments"><img alt="Research paper thumbnail of Triazole based Schiff bases and their oxovanadium(IV) complexes: Synthesis, characterization, antibacterial assay, and computational assessments" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701529/Triazole_based_Schiff_bases_and_their_oxovanadium_IV_complexes_Synthesis_characterization_antibacterial_assay_and_computational_assessments">Triazole based Schiff bases and their oxovanadium(IV) complexes: Synthesis, characterization, antibacterial assay, and computational assessments</a></div><div class="wp-workCard_item"><span>Heliyon</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701529"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701529"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701529; 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701528"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701528/Smartphone_Operated_Affordable_PCR_Thermal_Cycler_for_the_Detection_of_Antimicrobial_Resistant_Bacterial_Genes"><img alt="Research paper thumbnail of Smartphone-Operated Affordable PCR Thermal Cycler for the Detection of Antimicrobial Resistant Bacterial Genes" class="work-thumbnail" src="https://attachments.academia-assets.com/111327566/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701528/Smartphone_Operated_Affordable_PCR_Thermal_Cycler_for_the_Detection_of_Antimicrobial_Resistant_Bacterial_Genes">Smartphone-Operated Affordable PCR Thermal Cycler for the Detection of Antimicrobial Resistant Bacterial Genes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesAntimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesAntimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires affordable, rapid, and user-friendly diagnostic method. Our aim was to develop a low-cost thermocycler to perform polymerase chain reaction (PCR).MethodsWe developed a smartphone-operated PCR thermal cycler using locally available recycled materials. The thermal cycler was used for the amplification for three bacterial genes - bla-TEM and bla-CTXM and 16s rRNA in human urine samples. The performance of custom-built thermal cycler was compared with the commercial one.ResultsThe thermal cycler was portable (&lt;1kg weight), required 12 V power supply, 25 µL of solution, and cost only USD50.0. Temperature and time conditions were instructed using a custom-built smartphone application. The ramping rate of was 0.23°C for heating and 0.43°C for cooling, set temperatures were within ± 0.5 °C of target showing a good thermal stability. The antibiotic sensitivity test of human urine sample...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7e2796be4b019f719ff9db3f30e44dec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327566,"asset_id":114701528,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327566/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701528"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701528"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701528; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701527"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701527/Synthesis_Physico_Chemical_Studies_and_Biological_Activity_of_Glyoxalmonoisonicotinoyl_Hydrazone_Complexes_with_Some_Bivalent_Transition_Metal_Ions_and_Oxdcations"><img alt="Research paper thumbnail of Synthesis, Physico-Chemical Studies and Biological Activity of Glyoxalmonoisonicotinoyl Hydrazone Complexes with Some Bivalent Transition Metal Ions and Oxdcations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701527/Synthesis_Physico_Chemical_Studies_and_Biological_Activity_of_Glyoxalmonoisonicotinoyl_Hydrazone_Complexes_with_Some_Bivalent_Transition_Metal_Ions_and_Oxdcations">Synthesis, Physico-Chemical Studies and Biological Activity of Glyoxalmonoisonicotinoyl Hydrazone Complexes with Some Bivalent Transition Metal Ions and Oxdcations</a></div><div class="wp-workCard_item"><span>Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Complexes of the type MLX2 where M = Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II), Hg(II), VO(I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Complexes of the type MLX2 where M = Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II), Hg(II), VO(IV), ZrO(IV) and UO2(VI), L = glyoxalmonoisonicotinoyl hydra zone, X = Cl, NO3 and ½ SO4 have been synthesized and characterized by elemental analyses, physico-chemical and solid state conductance studies. The complexes are stable and insoluble except in DMF, DMSO and decompose above 200°C without</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701527"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701527"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701527; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701527]").text(description); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701526"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon"><img alt="Research paper thumbnail of Abnormal platelet aggregation in patients with Raynaud's phenomenon" class="work-thumbnail" src="https://attachments.academia-assets.com/111327567/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon">Abnormal platelet aggregation in patients with Raynaud's phenomenon</a></div><div class="wp-workCard_item"><span>Journal of Clinical Pathology</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosphate, adrenaline and collagen) was studied in 16 patients with primary and secondary Raynaud's phenomenon and compared with that in 13 normal volunteers. Platelets from patients with Raynaud's phenomenon had significantly greater responses to all the 5-HT concentrations</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="deb062b09692c2c148a0e807b2c1a6fd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327567,"asset_id":114701526,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327567/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701526"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701526"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701526; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701526]").text(description); $(".js-view-count[data-work-id=114701526]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701526; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701526']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "deb062b09692c2c148a0e807b2c1a6fd" } } $('.js-work-strip[data-work-id=114701526]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701526,"title":"Abnormal platelet aggregation in patients with Raynaud's phenomenon","internal_url":"https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[{"id":111327567,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111327567/thumbnails/1.jpg","file_name":"dd1caab00679113b0df895c3af7cb9125f42.pdf","download_url":"https://www.academia.edu/attachments/111327567/download_file","bulk_download_file_name":"Abnormal_platelet_aggregation_in_patient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111327567/dd1caab00679113b0df895c3af7cb9125f42-libre.pdf?1707527968=\u0026response-content-disposition=attachment%3B+filename%3DAbnormal_platelet_aggregation_in_patient.pdf\u0026Expires=1740881914\u0026Signature=S8zGH8FvvqD-46o8JNLsfzBOgt2cruW4FXnWDFZNdYMgsDvwtAg8ei279xLXzzDwMnZBwDdK4otDS8jljc3aIZxZK6pxxT2W~bSW0woHdqwryG1N02Qg4bOGELfmUY0KkcAGESI~MeHVUTFH5JCcB4Yr4UdLTHaEw6hpj65wEvolpeAsADAFIEgW3o7O3Ctsw2avMy2wbkXhZEZXjMsnciR1AqvEhDBItcJZ3S88mwZ8yP5d9etg4FV31Z051Kwr~eRczTWgtdS~aHcFmGt-rs8QQSZuD9BAFD8mG4Xragx59JB~ZH3jLyetlhI1X4gcaE7C7I-mbD07stIKcMvPZQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701507/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_a_boon_or_burden"><img alt="Research paper thumbnail of Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden" class="work-thumbnail" src="https://attachments.academia-assets.com/111327546/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701507/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_a_boon_or_burden">Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden</a></div><div class="wp-workCard_item"><span>BMC Research Notes</span><span>, Nov 8, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The study was carried out to optimize the phenotypic method to characterize the sickl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (ARMS PCR). Moreover, Glucose 6 phosphate dehydrogenase (G6PD) was estimated in those hemoglobinopathy to observe its prevalence. The accurate and reliable method can play an important role in reduction of morbidity and mortality rate. Results: The 100 suspected cases were subjected to phenotypic method adopting cellulose acetate electrophoresis and genotypic method using ARMS PCR which portraits (5%) SCA positive test showing HBS/HBS, (38%) SCT positive trait HBA/HBS and (36%) cases normal HBA/HBA. β-TT (21%) cases were confirmed by electropherogram. G6PD deficiency was observed in (40%) of SCA, (18.4%) of SCT, (4.8%) of β-TT and (2.8%) in normal cases. Increased G6PD were developed only in SCT (5.3%) and β-TT (4.8%). The study highlighted sickle cell disorder (SCD) and β-TT as the most common hemoglobinopathy coexisting with G6PD deficiency. Though hemoglobinopathy sometime could be protective in malaria but G6PD deficiency can cause massive hemolysis which may exacerbate the condition.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c2daaf24fc90d2a2529acc73c74f7efb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327546,"asset_id":114701507,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327546/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701507]").text(description); $(".js-view-count[data-work-id=114701507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c2daaf24fc90d2a2529acc73c74f7efb" } } $('.js-work-strip[data-work-id=114701507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701507,"title":"Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden","internal_url":"https://www.academia.edu/114701507/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_a_boon_or_burden","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[{"id":111327546,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111327546/thumbnails/1.jpg","file_name":"s13104-019-4762-6.pdf","download_url":"https://www.academia.edu/attachments/111327546/download_file","bulk_download_file_name":"Glucose_6_phosphate_dehydrogenase_defici.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111327546/s13104-019-4762-6-libre.pdf?1707527974=\u0026response-content-disposition=attachment%3B+filename%3DGlucose_6_phosphate_dehydrogenase_defici.pdf\u0026Expires=1740881914\u0026Signature=EZldA-uOqNpQoaNboRRhhNckYixHUENWXmxgfwMV4eFskiViAzXO4yyUhy7wiZL-rZ8BL4JaIlp6pARTOnus33JW7Oh8ZmVbP1uRxiv8QOrktsq3URbh29CMl6f1DDIj11cJr0RYVHWToVrQcZdMS6Md~AzaiLy3c9ysGaJ4lN~f7A8BXbHSqQv9hWCrYCdA-dgCQtVbfHVoYU12Fn32HEk1MOkbXGvWCZI1s6SRDg3QJskr5nsFlMWN~SAwuYqcZJv3gvuHwUXbIhtIMcpLJBJS3PDT~4h0TZvnbl4flzXgCnb1OsuJlgcoDPMPWogwjN4N9tgsnc03ULyFpiiUiw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":111327545,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111327545/thumbnails/1.jpg","file_name":"s13104-019-4762-6.pdf","download_url":"https://www.academia.edu/attachments/111327545/download_file","bulk_download_file_name":"Glucose_6_phosphate_dehydrogenase_defici.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111327545/s13104-019-4762-6-libre.pdf?1707527972=\u0026response-content-disposition=attachment%3B+filename%3DGlucose_6_phosphate_dehydrogenase_defici.pdf\u0026Expires=1740881914\u0026Signature=I9BQ~UUSzDvpN0UKTXTG9uBiOUietuxQR7e6g33lB0PUfxUEmas3~phFMeZr7lckBcn5SuFZMRQbGTkXBAUhRBslLbAPNqrt1Ax4Q7tHUCnwHjKGVbIRqv1vogMOzVaTEqwbwVE5vUwGBTH6UEfEtuDqsRv4NvoKiYSw-LuNhh0PiyHH5QbJI-7~lz1r~9CHlmRcTVIK5o-JTMN-a8IbJiUAS6fcIQ84Y2K0rRViK0nisq-wzd5UCtxPrViv3~9s~xF9z2ifrFBJPW8VN-SlU~DPQRBUpKft5~M~ZtUT9cFYKMRb8yTbJ8uZEllCTbtNGLlV0Fn5c57Hjlgv-PU8zw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701506/Biochemical_Analysis_and_Human_Aldose_Reductase_Inhibition_Activity_of_Selected_Medicinal_Plants_of_Nepal"><img alt="Research paper thumbnail of Biochemical Analysis and Human Aldose Reductase Inhibition Activity of Selected Medicinal Plants of Nepal" class="work-thumbnail" src="https://attachments.academia-assets.com/111327544/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701506/Biochemical_Analysis_and_Human_Aldose_Reductase_Inhibition_Activity_of_Selected_Medicinal_Plants_of_Nepal">Biochemical Analysis and Human Aldose Reductase Inhibition Activity of Selected Medicinal Plants of Nepal</a></div><div class="wp-workCard_item"><span>Journal of Chemistry</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aldose reductase has received extensive research as a key enzyme in the development of long-term ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aldose reductase has received extensive research as a key enzyme in the development of long-term problems linked to diabetes mellitus. Overexpression of this enzyme or with exceeded glucose concentration in the blood increases sorbitol on the retina leading to retinopathy, which is the adverse effect of type II diabetes. Approximately 100 million people are suffering from diabetic retinopathy globally. This research is focused on studying the total phenolic content (TPC), total flavonoid content (TFC), antioxidant potential, and aldose reductase inhibiting properties of selected medicinal plants such as Anacyclus pyrethrum, Bergenia ciliata, Rhododendron arboreum, and Swertia chirayita. In addition, ADMET analysis and molecular docking of seven previously identified compounds from the chosen medicinal plants were carried out against human aldose reductase (PDB ID: 4JIR). The ethanol extract of S. chirayita exhibited the highest TPC (4.63 ± 0.16 mg GAE/g) and TFC (0.90 ± 0.06 mg QE/g...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a46eb0fe8dd481b296301f6943b45749" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327544,"asset_id":114701506,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327544/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701506; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701505"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701505/In_Vitro_and_In_Silico_Studies_for_the_Identification_of_Potent_Metabolites_of_Some_High_Altitude_Medicinal_Plants_from_Nepal_Inhibiting_SARS_CoV_2_Spike_Protein"><img alt="Research paper thumbnail of In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein" class="work-thumbnail" src="https://attachments.academia-assets.com/111327542/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701505/In_Vitro_and_In_Silico_Studies_for_the_Identification_of_Potent_Metabolites_of_Some_High_Altitude_Medicinal_Plants_from_Nepal_Inhibiting_SARS_CoV_2_Spike_Protein">In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein</a></div><div class="wp-workCard_item"><span>Molecules</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite ongoing vaccination programs against COVID-19 around the world, cases of infection are st...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite ongoing vaccination programs against COVID-19 around the world, cases of infection are still rising with new variants. This infers that an effective antiviral drug against COVID-19 is crucial along with vaccinations to decrease cases. A potential target of such antivirals could be the membrane components of the causative pathogen, SARS-CoV-2, for instance spike (S) protein. In our research, we have deployed in vitro screening of crude extracts of seven ethnomedicinal plants against the spike receptor-binding domain (S1-RBD) of SARS-CoV-2 using an enzyme-linked immunosorbent assay (ELISA). Following encouraging in vitro results for Tinospora cordifolia, in silico studies were conducted for the 14 reported antiviral secondary metabolites isolated from T. cordifolia—a species widely cultivated and used as an antiviral drug in the Himalayan country of Nepal—using Genetic Optimization for Ligand Docking (GOLD), Molecular Operating Environment (MOE), and BIOVIA Discovery Studio. T...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4ba86503a51ffcd94fb18b24594f410b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327542,"asset_id":114701505,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327542/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701505"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701505"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701505; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701504/Knowledge_and_DdeI_Based_Confirmation_of_Sickle_Cell_Anemia_Among_the_Tharu_Community"><img alt="Research paper thumbnail of Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701504/Knowledge_and_DdeI_Based_Confirmation_of_Sickle_Cell_Anemia_Among_the_Tharu_Community">Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community</a></div><div class="wp-workCard_item"><span>Journal of Nepal Health Research Council</span><span>, Nov 3, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701504; 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Etiology of this disease is complex; however, in a subtype called Early Onset Alzheimer’s Disease (EOAD) which manifests at age below 65 years, genes are the sole cause — mutations in APP, PSEN1 and PSEN2 genes. Currently, there is no effective cure for AD. Therefore, a thorough understanding of pathogenesis of AD is crucial for designing drug-development studies. However, our knowledge is only in the growing phase in this fi eld. This paper briefl y reviews the pathogenesis of EOAD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6f644364aaaf2313afb97f348657bf5f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86705648,"asset_id":80267032,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86705648/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80267032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80267032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80267032; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80267030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/80267030/Potential_roles_of_medicinal_plants_for_the_treatment_of_viral_diseases_focusing_on_COVID_19_A_review"><img alt="Research paper thumbnail of Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: A review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/80267030/Potential_roles_of_medicinal_plants_for_the_treatment_of_viral_diseases_focusing_on_COVID_19_A_review">Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: A review</a></div><div class="wp-workCard_item"><span>Phytotherapy Research</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused by severe acut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin‐gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID‐19. Moreover, these could also show promising inhibitory effects against influenza‐parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS‐CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80267030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80267030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80267030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80267030]").text(description); 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</script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="10399371" id="papers"><div class="js-work-strip profile--work_container" data-work-id="114701539"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers"><img alt="Research paper thumbnail of Cytotoxic Activity of Alkaloids Isolated from <i>Stephania glandulifera</i> Miers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers">Cytotoxic Activity of Alkaloids Isolated from <i>Stephania glandulifera</i> Miers</a></div><div class="wp-workCard_item"><span>Journal of biologically active products from nature</span><span>, Mar 4, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701539"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701539"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701539; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701539]").text(description); $(".js-view-count[data-work-id=114701539]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701539; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701539']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701539]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701539,"title":"Cytotoxic Activity of Alkaloids Isolated from \u003ci\u003eStephania glandulifera\u003c/i\u003e Miers","internal_url":"https://www.academia.edu/114701539/Cytotoxic_Activity_of_Alkaloids_Isolated_from_i_Stephania_glandulifera_i_Miers","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701538/Smartphone_operated_affordable_PCR_thermal_cycler_for_the_detection_of_antimicrobial_resistant_bacterial_genes"><img alt="Research paper thumbnail of Smartphone-operated affordable PCR thermal cycler for the detection of antimicrobial resistant bacterial genes" class="work-thumbnail" src="https://attachments.academia-assets.com/111327559/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701538/Smartphone_operated_affordable_PCR_thermal_cycler_for_the_detection_of_antimicrobial_resistant_bacterial_genes">Smartphone-operated affordable PCR thermal cycler for the detection of antimicrobial resistant bacterial genes</a></div><div class="wp-workCard_item"><span>PLOS global public health</span><span>, Feb 27, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Antimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires aff...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Antimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires affordable, rapid, and user-friendly diagnostic methods. Our aim was to develop a low-cost thermocycler to perform polymerase chain reaction (PCR). We developed a smartphoneoperated PCR thermal cycler using locally available recycled materials. The thermal cycler was used for the amplification for three bacterial genes-bla-TEM, bla-CTXM and 16s rRNA in human urine samples. The performance of custom-built thermal cycler was compared with commercial thermal cycler. The thermal cycler was portable (<1kg weight), required 12 V power supply, 25 μL of solution, and cost only USD50.0. Temperature and time conditions were instructed using a custom-built smartphone application. The ramping rate of was 0.23˚C for heating and 0.43˚C for cooling. The reported temperatures were within ± 0.5˚C of set temperature. The human urine samples were highly resistance and multi-resistant. Nearly 46% (n = 54) E. coli isolates were positive in ESBL screening test. The custom-built thermocycler was able to accurately predict the presence of bla-TEM, bla-CTXM genes, and 16s rRNA (n = 6). We developed and demonstrated a portable, low-cost, easy-to-use, and smartphone-operated PCR thermal cycler. Since it is portable, it can be used in remote location and field settings, including places without stable power supply. The use of the thermal cycler system can be extended, beyond the detection of AMR genes, e.g., in clinical diagnosis, genetics, forensic analysis, and environmental protection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3b6e340bc27796814ea51fdee99254bf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327559,"asset_id":114701538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327559/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701538; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701537"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701537/Vaccines_and_the_role_of_the_immune_system_An_approach_in_decreasing_COVID_19_mortality"><img alt="Research paper thumbnail of Vaccines and the role of the immune system: An approach in decreasing COVID -19 mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/111327565/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701537/Vaccines_and_the_role_of_the_immune_system_An_approach_in_decreasing_COVID_19_mortality">Vaccines and the role of the immune system: An approach in decreasing COVID -19 mortality</a></div><div class="wp-workCard_item"><span>International Journal of medicine and bi-medical sciences</span><span>, Dec 29, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8c4e03bd038684bd9c8c7499508423c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327565,"asset_id":114701537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327565/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701537; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701537]").text(description); $(".js-view-count[data-work-id=114701537]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701537; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701537']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701536/Synthesis_and_Characterization_of_High_Molecular_Weight_Chitosan_and_Antioxidant_Activity_of_Its_Chitosan_Oligosaccharide_Encapsulation"><img alt="Research paper thumbnail of Synthesis and Characterization of High Molecular Weight Chitosan, and Antioxidant Activity of Its Chitosan Oligosaccharide Encapsulation" class="work-thumbnail" src="https://attachments.academia-assets.com/111327557/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701536/Synthesis_and_Characterization_of_High_Molecular_Weight_Chitosan_and_Antioxidant_Activity_of_Its_Chitosan_Oligosaccharide_Encapsulation">Synthesis and Characterization of High Molecular Weight Chitosan, and Antioxidant Activity of Its Chitosan Oligosaccharide Encapsulation</a></div><div class="wp-workCard_item"><span>Journal of Nepal Chemical Society</span><span>, Mar 1, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High molecular weight nanocrystalline chitosan (HMWNC) with M w of 350 kDa and 66.92% DDA was pre...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High molecular weight nanocrystalline chitosan (HMWNC) with M w of 350 kDa and 66.92% DDA was prepared by alkaline N-deacetylation of chitin that was abundantly obtained after demineralization and deproteinization of pulverized crab shells, and commercially available chitosan oligosaccharide (COS) with average M w < 3000 Da and 87% DDA was encapsulated with HMWNC. The encapsulation of COS as a pharmaceutical ingredient into HMWC was hypothesized to enhance the bioavailability of COS in target cells. The HMWNC encapsulated chitosan oligosaccharide (COS-HMWNC) showed in vitro antioxidant activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC 50 = 512.6±14.4 μg/mL) while others showed less than 50% inhibition at 1000 μg/mL. The lower the molecular weight of chitosan, the higher was the antioxidant activity. The study showed that the encapsulation of COS molecules in HMWNC could be used as a simple and effective way of enhancing the antioxidant activity of COS.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6f38201d3af1a59fc4500e0a0ba4957e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327557,"asset_id":114701536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327557/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701536; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701535"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701535/Synthesis_and_enzyme_inhibitory_activities_of_some_new_pyrazole_based_heterocyclic_compounds"><img alt="Research paper thumbnail of Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701535/Synthesis_and_enzyme_inhibitory_activities_of_some_new_pyrazole_based_heterocyclic_compounds">Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds</a></div><div class="wp-workCard_item"><span>Medicinal Chemistry Research</span><span>, Oct 21, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Three tridentate N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (2),...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Three tridentate N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (2), N, N-bis (3, 5-dimethylpyrazol-1-ylmethyl)-cyclohexylamine (3) and 2-[bis (1, 5-dimethyl-1H-pyrazol-3-ylmethyl) amino] ethan-1-ol (4) are synthesized and ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701535"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701535"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701535; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers"><img alt="Research paper thumbnail of Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers">Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers</a></div><div class="wp-workCard_item"><span>Journal of Biologically Active Products from Nature</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701533; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701533]").text(description); $(".js-view-count[data-work-id=114701533]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701533; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701533']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701533]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701533,"title":"Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers","internal_url":"https://www.academia.edu/114701533/Cytotoxic_Activity_of_Alkaloids_Isolated_from_Stephania_glandulifera_Miers","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701532"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701532/Global_regional_and_national_prevalence_and_mortality_burden_of_sickle_cell_disease_2000_2021_a_systematic_analysis_from_the_Global_Burden_of_Disease_Study_2021"><img alt="Research paper thumbnail of Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701532/Global_regional_and_national_prevalence_and_mortality_burden_of_sickle_cell_disease_2000_2021_a_systematic_analysis_from_the_Global_Burden_of_Disease_Study_2021">Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021</a></div><div class="wp-workCard_item"><span>The Lancet Haematology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Previous global analyses, with known underdiagnosis and single cause per death attribu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. Methods We estimated cause-specific sickle cell disease mortality using standardised GBD approaches, in which each death is assigned to a single underlying cause, to estimate mortality rates from the International Classification of Diseases (ICD)-coded vital registration, surveillance, and verbal autopsy data. In parallel, our goal was to estimate a more accurate account of sickle cell disease health burden using four types of epidemiological data on sickle cell disease: birth incidence, age-specific prevalence, with-condition mortality (total deaths), and excess mortality (excess deaths). Systematic reviews, supplemented with ICD-coded hospital discharge and insurance claims data, informed this modelling approach. We employed DisMod-MR 2.1 to triangulate between these measures-borrowing strength from predictive covariates and across age, time, and geography-and generated internally consistent estimates of incidence, prevalence, and mortality for three distinct genotypes of sickle cell disease: homozygous sickle cell disease and severe sickle cell β-thalassaemia, sickle-haemoglobin C disease, and mild sickle cell β-thalassaemia. Summing the three models yielded final estimates of incidence at birth, prevalence by age and sex, and total sickle cell disease mortality, the latter of which was compared directly against cause-specific mortality estimates to evaluate differences in mortality burden assessment and implications for the Sustainable Development Goals (SDGs). Findings Between 2000 and 2021, national incidence rates of sickle cell disease were relatively stable, but total births of babies with sickle cell disease increased globally by 13•7% (95% uncertainty interval 11•1-16•5), to 515 000 (425 000-614 000), primarily due to population growth in the Caribbean and western and central sub-Saharan Africa. The number of people living with sickle cell disease globally increased by 41•4% (38•3-44•9), from 5•46 million (4•62-6•45) in 2000 to 7•74 million (6•51-9•2) in 2021. We estimated 34 400 (25 000-45 200) cause-specific all-age deaths globally in 2021, but total sickle cell disease mortality burden was nearly 11-times higher at 376 000 (303 000-467 000). In children younger than 5 years, there were 81 100 (58 800-108 000) deaths, ranking total sickle cell disease mortality as 12th (compared to 40th for cause-specific sickle cell disease mortality) across all causes estimated by the GBD in 2021. Interpretation Our findings show a strikingly high contribution of sickle cell disease to all-cause mortality that is not apparent when each death is assigned to only a single cause. Sickle cell disease mortality burden is highest in children, especially in countries with the greatest under-5 mortality rates. Without comprehensive strategies to address morbidity and mortality associated with sickle cell disease, attainment of SDG 3.1, 3.2, and 3.4 is uncertain. Widespread data gaps and correspondingly high uncertainty in the estimates highlight the urgent need for routine and sustained surveillance efforts, further research to assess the contribution of conditions associated with sickle cell disease, and widespread deployment of evidence-based prevention and treatment for those with sickle cell disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701532"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701532"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701532; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701531"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review"><img alt="Research paper thumbnail of Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review">Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review</a></div><div class="wp-workCard_item"><span>Microbiology Insights</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Antimicrobial resistance (AMR) is increasing and it is a serious public health problem worldwide....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Antimicrobial resistance (AMR) is increasing and it is a serious public health problem worldwide. Nepal is considered as one of the contributors for rising AMR due to the most prevalent irrational use of antibiotics. In this review, we have assessed the practices of antibiotic prescription and dispensing, and antibiotic resistance of commonly encountered bacteria in Nepal. There is exponential increase of therapeutic consumption of antibiotics either without clinician’s prescription or irrational prescription. Almost half of the population in Nepal was found to purchase antibiotics easily from the nearby pharmacies without clinician’s prescription. Irrational prescription is exceeded in remote areas which could be due to lack of access with health posts and hospitals. The third generation cephalosporins, which are considered as the last resort antibiotics were found to be relatively prescribed and dispensed higher as compared to other classes of antibiotics. Despite the existing lim...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701531"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701531"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701531; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701531]").text(description); $(".js-view-count[data-work-id=114701531]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701531; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701531']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701531]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701531,"title":"Antibiotics Prescription, Dispensing Practices and Antibiotic Resistance Pattern in Common Pathogens in Nepal: A Narrative Review","internal_url":"https://www.academia.edu/114701531/Antibiotics_Prescription_Dispensing_Practices_and_Antibiotic_Resistance_Pattern_in_Common_Pathogens_in_Nepal_A_Narrative_Review","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701530"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701530/Oxovanadium_IV_Complexes_with_Triazole_Based_Schiff_Base_Ligands_Synthesis_Characterization_and_Antibacterial_Study"><img alt="Research paper thumbnail of Oxovanadium(IV) Complexes with Triazole Based Schiff Base Ligands: Synthesis, Characterization and Antibacterial Study" class="work-thumbnail" src="https://attachments.academia-assets.com/111327553/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701530/Oxovanadium_IV_Complexes_with_Triazole_Based_Schiff_Base_Ligands_Synthesis_Characterization_and_Antibacterial_Study">Oxovanadium(IV) Complexes with Triazole Based Schiff Base Ligands: Synthesis, Characterization and Antibacterial Study</a></div><div class="wp-workCard_item"><span>Journal of Nepal Chemical Society</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Schiff bases have been synthesized by the reaction of triazole containing primary amine with arom...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Schiff bases have been synthesized by the reaction of triazole containing primary amine with aromatic carbonyl compounds. The Schiff bases prepared, act as ligand when these are made in contact with oxovanadium (VO2+) ion. Some new mononuclear oxovanadium(IV) complexes have been synthesized by the reaction of Schiff base ligands with vanadyl sulphate (VOSO4.xH2O) and the complexes are analyzed by different spectroscopic methods; [fourier-transform infrared (FTIR), ultraviolet-visible (UV-Vis.), electron paramagnetic resonance (EPR)], X-ray diffraction (XRD) analysis, elemental analysis, and conductivity measurement. The complexes have been well characterized based on analytical data. The electrolytic nature of the complexes was determined based on the molar conductance values. The powder XRD pattern has been used to determine crystal size and type. The synthesized Schiff base ligands and oxovanadium(IV) complexes were found to be stable in air and moisture at room temperature. On t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="107d4417fb8c215d3db507d36127e3e2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327553,"asset_id":114701530,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327553/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701530"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701530"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701530; 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701528"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701528/Smartphone_Operated_Affordable_PCR_Thermal_Cycler_for_the_Detection_of_Antimicrobial_Resistant_Bacterial_Genes"><img alt="Research paper thumbnail of Smartphone-Operated Affordable PCR Thermal Cycler for the Detection of Antimicrobial Resistant Bacterial Genes" class="work-thumbnail" src="https://attachments.academia-assets.com/111327566/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701528/Smartphone_Operated_Affordable_PCR_Thermal_Cycler_for_the_Detection_of_Antimicrobial_Resistant_Bacterial_Genes">Smartphone-Operated Affordable PCR Thermal Cycler for the Detection of Antimicrobial Resistant Bacterial Genes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesAntimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesAntimicrobial resistance (AMR) is a global public health threat. Surveillance of AMR requires affordable, rapid, and user-friendly diagnostic method. Our aim was to develop a low-cost thermocycler to perform polymerase chain reaction (PCR).MethodsWe developed a smartphone-operated PCR thermal cycler using locally available recycled materials. The thermal cycler was used for the amplification for three bacterial genes - bla-TEM and bla-CTXM and 16s rRNA in human urine samples. The performance of custom-built thermal cycler was compared with the commercial one.ResultsThe thermal cycler was portable (&lt;1kg weight), required 12 V power supply, 25 µL of solution, and cost only USD50.0. Temperature and time conditions were instructed using a custom-built smartphone application. The ramping rate of was 0.23°C for heating and 0.43°C for cooling, set temperatures were within ± 0.5 °C of target showing a good thermal stability. The antibiotic sensitivity test of human urine sample...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7e2796be4b019f719ff9db3f30e44dec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327566,"asset_id":114701528,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327566/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701528"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701528"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701528; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701528]").text(description); $(".js-view-count[data-work-id=114701528]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701528; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701528']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7e2796be4b019f719ff9db3f30e44dec" } } $('.js-work-strip[data-work-id=114701528]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701528,"title":"Smartphone-Operated Affordable PCR Thermal Cycler for the Detection of Antimicrobial Resistant Bacterial Genes","internal_url":"https://www.academia.edu/114701528/Smartphone_Operated_Affordable_PCR_Thermal_Cycler_for_the_Detection_of_Antimicrobial_Resistant_Bacterial_Genes","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[{"id":111327566,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111327566/thumbnails/1.jpg","file_name":"2022.05.27.493737.full.pdf","download_url":"https://www.academia.edu/attachments/111327566/download_file","bulk_download_file_name":"Smartphone_Operated_Affordable_PCR_Therm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111327566/2022.05.27.493737.full-libre.pdf?1707527970=\u0026response-content-disposition=attachment%3B+filename%3DSmartphone_Operated_Affordable_PCR_Therm.pdf\u0026Expires=1740881914\u0026Signature=OzXBYzgRguhySu~dxQD3YdEHw6soAmVTnWHnk3e8ih6T1RbqdwTy3yhCbr0xJC5vz-JLjdFuGEDNN17worlXTuB-q2RBCuGgMteX6BXDDMCGpccDNcI3BDyrdJZpn6NAWEmh3MSt~2r60Ht0bs5x0N02Gyew4kQZ2LrXYQRED670XeQ8t9mB8YeBlcrrLtLpUC0ns~obcnPxa9wgpuOyXozGF12d3B6Gtl~KjrG7u8fnC~5Gfi8lrMH3OIJdPAEXBOKfHTxfKCv3qnhwlcYUBoCzVIwI7fhRtYCzHQnK0XC00u6o-Yx~SjoI6EXspYYeSJvjm48BDHjVZWLq0x0rLw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701527"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701527/Synthesis_Physico_Chemical_Studies_and_Biological_Activity_of_Glyoxalmonoisonicotinoyl_Hydrazone_Complexes_with_Some_Bivalent_Transition_Metal_Ions_and_Oxdcations"><img alt="Research paper thumbnail of Synthesis, Physico-Chemical Studies and Biological Activity of Glyoxalmonoisonicotinoyl Hydrazone Complexes with Some Bivalent Transition Metal Ions and Oxdcations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701527/Synthesis_Physico_Chemical_Studies_and_Biological_Activity_of_Glyoxalmonoisonicotinoyl_Hydrazone_Complexes_with_Some_Bivalent_Transition_Metal_Ions_and_Oxdcations">Synthesis, Physico-Chemical Studies and Biological Activity of Glyoxalmonoisonicotinoyl Hydrazone Complexes with Some Bivalent Transition Metal Ions and Oxdcations</a></div><div class="wp-workCard_item"><span>Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Complexes of the type MLX2 where M = Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II), Hg(II), VO(I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Complexes of the type MLX2 where M = Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II), Hg(II), VO(IV), ZrO(IV) and UO2(VI), L = glyoxalmonoisonicotinoyl hydra zone, X = Cl, NO3 and ½ SO4 have been synthesized and characterized by elemental analyses, physico-chemical and solid state conductance studies. The complexes are stable and insoluble except in DMF, DMSO and decompose above 200°C without</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701527"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701527"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701527; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701527]").text(description); $(".js-view-count[data-work-id=114701527]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701527; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701527']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114701527]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701527,"title":"Synthesis, Physico-Chemical Studies and Biological Activity of Glyoxalmonoisonicotinoyl Hydrazone Complexes with Some Bivalent Transition Metal Ions and Oxdcations","internal_url":"https://www.academia.edu/114701527/Synthesis_Physico_Chemical_Studies_and_Biological_Activity_of_Glyoxalmonoisonicotinoyl_Hydrazone_Complexes_with_Some_Bivalent_Transition_Metal_Ions_and_Oxdcations","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701526"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon"><img alt="Research paper thumbnail of Abnormal platelet aggregation in patients with Raynaud's phenomenon" class="work-thumbnail" src="https://attachments.academia-assets.com/111327567/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon">Abnormal platelet aggregation in patients with Raynaud's phenomenon</a></div><div class="wp-workCard_item"><span>Journal of Clinical Pathology</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosph...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosphate, adrenaline and collagen) was studied in 16 patients with primary and secondary Raynaud's phenomenon and compared with that in 13 normal volunteers. Platelets from patients with Raynaud's phenomenon had significantly greater responses to all the 5-HT concentrations</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="deb062b09692c2c148a0e807b2c1a6fd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327567,"asset_id":114701526,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327567/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701526"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701526"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701526; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114701526]").text(description); $(".js-view-count[data-work-id=114701526]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114701526; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114701526']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "deb062b09692c2c148a0e807b2c1a6fd" } } $('.js-work-strip[data-work-id=114701526]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114701526,"title":"Abnormal platelet aggregation in patients with Raynaud's phenomenon","internal_url":"https://www.academia.edu/114701526/Abnormal_platelet_aggregation_in_patients_with_Raynauds_phenomenon","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[{"id":111327567,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111327567/thumbnails/1.jpg","file_name":"dd1caab00679113b0df895c3af7cb9125f42.pdf","download_url":"https://www.academia.edu/attachments/111327567/download_file","bulk_download_file_name":"Abnormal_platelet_aggregation_in_patient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111327567/dd1caab00679113b0df895c3af7cb9125f42-libre.pdf?1707527968=\u0026response-content-disposition=attachment%3B+filename%3DAbnormal_platelet_aggregation_in_patient.pdf\u0026Expires=1740881914\u0026Signature=S8zGH8FvvqD-46o8JNLsfzBOgt2cruW4FXnWDFZNdYMgsDvwtAg8ei279xLXzzDwMnZBwDdK4otDS8jljc3aIZxZK6pxxT2W~bSW0woHdqwryG1N02Qg4bOGELfmUY0KkcAGESI~MeHVUTFH5JCcB4Yr4UdLTHaEw6hpj65wEvolpeAsADAFIEgW3o7O3Ctsw2avMy2wbkXhZEZXjMsnciR1AqvEhDBItcJZ3S88mwZ8yP5d9etg4FV31Z051Kwr~eRczTWgtdS~aHcFmGt-rs8QQSZuD9BAFD8mG4Xragx59JB~ZH3jLyetlhI1X4gcaE7C7I-mbD07stIKcMvPZQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701507/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_a_boon_or_burden"><img alt="Research paper thumbnail of Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden" class="work-thumbnail" src="https://attachments.academia-assets.com/111327546/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701507/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_a_boon_or_burden">Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden</a></div><div class="wp-workCard_item"><span>BMC Research Notes</span><span>, Nov 8, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: The study was carried out to optimize the phenotypic method to characterize the sickl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (ARMS PCR). Moreover, Glucose 6 phosphate dehydrogenase (G6PD) was estimated in those hemoglobinopathy to observe its prevalence. The accurate and reliable method can play an important role in reduction of morbidity and mortality rate. Results: The 100 suspected cases were subjected to phenotypic method adopting cellulose acetate electrophoresis and genotypic method using ARMS PCR which portraits (5%) SCA positive test showing HBS/HBS, (38%) SCT positive trait HBA/HBS and (36%) cases normal HBA/HBA. β-TT (21%) cases were confirmed by electropherogram. G6PD deficiency was observed in (40%) of SCA, (18.4%) of SCT, (4.8%) of β-TT and (2.8%) in normal cases. Increased G6PD were developed only in SCT (5.3%) and β-TT (4.8%). The study highlighted sickle cell disorder (SCD) and β-TT as the most common hemoglobinopathy coexisting with G6PD deficiency. Though hemoglobinopathy sometime could be protective in malaria but G6PD deficiency can cause massive hemolysis which may exacerbate the condition.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c2daaf24fc90d2a2529acc73c74f7efb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327546,"asset_id":114701507,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327546/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701507; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701506/Biochemical_Analysis_and_Human_Aldose_Reductase_Inhibition_Activity_of_Selected_Medicinal_Plants_of_Nepal"><img alt="Research paper thumbnail of Biochemical Analysis and Human Aldose Reductase Inhibition Activity of Selected Medicinal Plants of Nepal" class="work-thumbnail" src="https://attachments.academia-assets.com/111327544/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701506/Biochemical_Analysis_and_Human_Aldose_Reductase_Inhibition_Activity_of_Selected_Medicinal_Plants_of_Nepal">Biochemical Analysis and Human Aldose Reductase Inhibition Activity of Selected Medicinal Plants of Nepal</a></div><div class="wp-workCard_item"><span>Journal of Chemistry</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aldose reductase has received extensive research as a key enzyme in the development of long-term ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aldose reductase has received extensive research as a key enzyme in the development of long-term problems linked to diabetes mellitus. Overexpression of this enzyme or with exceeded glucose concentration in the blood increases sorbitol on the retina leading to retinopathy, which is the adverse effect of type II diabetes. Approximately 100 million people are suffering from diabetic retinopathy globally. This research is focused on studying the total phenolic content (TPC), total flavonoid content (TFC), antioxidant potential, and aldose reductase inhibiting properties of selected medicinal plants such as Anacyclus pyrethrum, Bergenia ciliata, Rhododendron arboreum, and Swertia chirayita. In addition, ADMET analysis and molecular docking of seven previously identified compounds from the chosen medicinal plants were carried out against human aldose reductase (PDB ID: 4JIR). The ethanol extract of S. chirayita exhibited the highest TPC (4.63 ± 0.16 mg GAE/g) and TFC (0.90 ± 0.06 mg QE/g...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a46eb0fe8dd481b296301f6943b45749" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327544,"asset_id":114701506,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327544/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701506; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701505"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114701505/In_Vitro_and_In_Silico_Studies_for_the_Identification_of_Potent_Metabolites_of_Some_High_Altitude_Medicinal_Plants_from_Nepal_Inhibiting_SARS_CoV_2_Spike_Protein"><img alt="Research paper thumbnail of In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein" class="work-thumbnail" src="https://attachments.academia-assets.com/111327542/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114701505/In_Vitro_and_In_Silico_Studies_for_the_Identification_of_Potent_Metabolites_of_Some_High_Altitude_Medicinal_Plants_from_Nepal_Inhibiting_SARS_CoV_2_Spike_Protein">In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein</a></div><div class="wp-workCard_item"><span>Molecules</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite ongoing vaccination programs against COVID-19 around the world, cases of infection are st...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite ongoing vaccination programs against COVID-19 around the world, cases of infection are still rising with new variants. This infers that an effective antiviral drug against COVID-19 is crucial along with vaccinations to decrease cases. A potential target of such antivirals could be the membrane components of the causative pathogen, SARS-CoV-2, for instance spike (S) protein. In our research, we have deployed in vitro screening of crude extracts of seven ethnomedicinal plants against the spike receptor-binding domain (S1-RBD) of SARS-CoV-2 using an enzyme-linked immunosorbent assay (ELISA). Following encouraging in vitro results for Tinospora cordifolia, in silico studies were conducted for the 14 reported antiviral secondary metabolites isolated from T. cordifolia—a species widely cultivated and used as an antiviral drug in the Himalayan country of Nepal—using Genetic Optimization for Ligand Docking (GOLD), Molecular Operating Environment (MOE), and BIOVIA Discovery Studio. T...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4ba86503a51ffcd94fb18b24594f410b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111327542,"asset_id":114701505,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111327542/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701505"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701505"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701505; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114701504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114701504/Knowledge_and_DdeI_Based_Confirmation_of_Sickle_Cell_Anemia_Among_the_Tharu_Community"><img alt="Research paper thumbnail of Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114701504/Knowledge_and_DdeI_Based_Confirmation_of_Sickle_Cell_Anemia_Among_the_Tharu_Community">Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community</a></div><div class="wp-workCard_item"><span>Journal of Nepal Health Research Council</span><span>, Nov 3, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114701504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114701504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114701504; 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Etiology of this disease is complex; however, in a subtype called Early Onset Alzheimer’s Disease (EOAD) which manifests at age below 65 years, genes are the sole cause — mutations in APP, PSEN1 and PSEN2 genes. Currently, there is no effective cure for AD. Therefore, a thorough understanding of pathogenesis of AD is crucial for designing drug-development studies. However, our knowledge is only in the growing phase in this fi eld. This paper briefl y reviews the pathogenesis of EOAD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6f644364aaaf2313afb97f348657bf5f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86705648,"asset_id":80267032,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86705648/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80267032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80267032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80267032; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80267030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/80267030/Potential_roles_of_medicinal_plants_for_the_treatment_of_viral_diseases_focusing_on_COVID_19_A_review"><img alt="Research paper thumbnail of Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: A review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/80267030/Potential_roles_of_medicinal_plants_for_the_treatment_of_viral_diseases_focusing_on_COVID_19_A_review">Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: A review</a></div><div class="wp-workCard_item"><span>Phytotherapy Research</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused by severe acut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin‐gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID‐19. Moreover, these could also show promising inhibitory effects against influenza‐parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS‐CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80267030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80267030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80267030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80267030]").text(description); 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</script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="10399517" id="articles"><div class="js-work-strip profile--work_container" data-work-id="43112068"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112068/Isolation_and_Characterization_of_Soil_Myxobacteria_from_Nepal"><img alt="Research paper thumbnail of Isolation and Characterization of Soil Myxobacteria from Nepal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112068/Isolation_and_Characterization_of_Soil_Myxobacteria_from_Nepal">Isolation and Characterization of Soil Myxobacteria from Nepal</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112068"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112068"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112068; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112068]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112068,"title":"Isolation and Characterization of Soil Myxobacteria from Nepal","internal_url":"https://www.academia.edu/43112068/Isolation_and_Characterization_of_Soil_Myxobacteria_from_Nepal","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112067"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112067/Extended_spectrum_lactamase_producing_uropathogenic_Escherichia_coli_and_the_correlation_of_biofilm_with_antibiotics_resistance_in_Nepal"><img alt="Research paper thumbnail of Extended spectrum ?-lactamase producing uropathogenic Escherichia coli and the correlation of biofilm with antibiotics resistance in Nepal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112067/Extended_spectrum_lactamase_producing_uropathogenic_Escherichia_coli_and_the_correlation_of_biofilm_with_antibiotics_resistance_in_Nepal">Extended spectrum ?-lactamase producing uropathogenic Escherichia coli and the correlation of biofilm with antibiotics resistance in Nepal</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112067"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112067"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112067; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112067]").text(description); $(".js-view-count[data-work-id=43112067]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112067; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112067']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112066"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112066/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_A_boon_or_burden"><img alt="Research paper thumbnail of Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: A boon or burden" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112066/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_A_boon_or_burden">Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: A boon or burden</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112066"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112066"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112066; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112066]").text(description); $(".js-view-count[data-work-id=43112066]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112066; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112066']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112066]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112066,"title":"Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: A boon or burden","internal_url":"https://www.academia.edu/43112066/Glucose_6_phosphate_dehydrogenase_deficiency_and_hemoglobinopathy_in_South_Western_Region_Nepal_A_boon_or_burden","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112065"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112065/Total_Biomass_Carbon_Sequestration_Ability_Under_the_Changing_Climatic_Condition_by_Paulownia_tomentosa_Steud"><img alt="Research paper thumbnail of Total Biomass Carbon Sequestration Ability Under the Changing Climatic Condition by Paulownia tomentosa Steud" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112065/Total_Biomass_Carbon_Sequestration_Ability_Under_the_Changing_Climatic_Condition_by_Paulownia_tomentosa_Steud">Total Biomass Carbon Sequestration Ability Under the Changing Climatic Condition by Paulownia tomentosa Steud</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The concentration of carbon dioxide (CO2) has risen continuously in atmosphere due to human induc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The concentration of carbon dioxide (CO2) has risen continuously in atmosphere due to human induced activities, and has been considered the predominant cause of global climate change. Paulowina tomentosa Steud. (P. tomentosa), a multipurpose tree is popular around global market for its timber and its potential role in CO2 sequestration. In this study, the total biomass carbon of five years old and newly planted P. tomentosa has been estimated. The results indicated that the average total biomass carbon of five years old plant was found to be 4.52±0.53Kg C Year-1 per tree i.e. 9.04±1.06-ton C ha-1 Year-1 (assuming 2000 plants per hector). Likewise, the average total biomass carbon of newly planted P. tomentosa within 4 months was found to be 6.07±0.38 Kg in remote village area in Nepal. The estimated biomass carbon in one year of newly planted plants was found to be 18.21±1.14 Kg Year-1 i.e. 0.36-ton C ha-1 Year-1. These findings reveled that short rotational trees like P. tomentosa can be implemented in agroforestry system to reduce the green house emission in cities and emphasizes the carbon storage potential of agroforestry. In vitro micro propagation technique could be implemented to produce genetically uniform clone of P. tomentosa and can be applied in agroforestry system for the adaptation and to mitigate global climate change.Int. J. Appl. Sci. Biotechnol. Vol 6(3): 220-226</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112065"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112065"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112065; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112065]").text(description); $(".js-view-count[data-work-id=43112065]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112065; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112065']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112065]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112065,"title":"Total Biomass Carbon Sequestration Ability Under the Changing Climatic Condition by Paulownia tomentosa Steud","internal_url":"https://www.academia.edu/43112065/Total_Biomass_Carbon_Sequestration_Ability_Under_the_Changing_Climatic_Condition_by_Paulownia_tomentosa_Steud","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112064"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112064/Challenges_and_Opportunity_of_in_vitro_Propagation_of_Paulownia_tomentosa_Steud_for_Commercial_Production_in_Nepal"><img alt="Research paper thumbnail of Challenges and Opportunity of in vitro Propagation of Paulownia tomentosa Steud for Commercial Production in Nepal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112064/Challenges_and_Opportunity_of_in_vitro_Propagation_of_Paulownia_tomentosa_Steud_for_Commercial_Production_in_Nepal">Challenges and Opportunity of in vitro Propagation of Paulownia tomentosa Steud for Commercial Production in Nepal</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Paulownia tomentosa Steud is a fast growing multipurpose tree. In vitro propagation using nodal e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Paulownia tomentosa Steud is a fast growing multipurpose tree. In vitro propagation using nodal explants of Paulownia tomentosa was performed by manipulating amount of cytokinin and auxin in culture media. Shoot bud proliferation from explants were assessed in Murashige and Skoog (MS) medium supplemented with various amounts of hormones such as a) 0.5-2.5 mg/l benzylaminopurine (BAP) and 0.1 mg/l naphthalene acetic acid (NAA), b) 0.5-2.5 mg/l BAP and 0.5-2.5 mg/l kinetin (KN) and c) 0.5- 2.5 mg/l BAP and 0.1 mg/l indole-3-acetic acid (IAA). In the present study, we found that hormone combination of BAP and NAA gave optimum growth results. MS medium enriched with 2.0 mg/l BAP and 0.1 mg/l IAA resulted a similar outcome but took 3-4 weeks with respect to the same medium enriched with 1.0 mg/ml BAP and 0.1 mg/ml NAA, which showed response within 2-3 weeks. Shoot length of 2.5-3.5 cm with 3-4 nodes and 8-12 leaves were obtained on MS medium supplemented with 1.0 mg/l BAP and 0.1 mg/l NAA. The acclimatization of explants was done in a polyhouse at 20±5oC for 2-6 weeks. Rooting has been induced in nonsterile sand. Rooted plants were transferred to plastic bags containing mixture of soil, sand and compost in the ratio of 1:1:1.Besides aforementioned issues, there are several other challenges associated with in vitro propagation of P. tomentosa. The plants were established (90%) on MS medium enriched with BAP and NAA and adapted ex vitro with surviving up to 80%. People received an opportunity with this plant because it grows fast and can generate income in 10 years in comparison with others, but at the same time people also have been facing the challenges for plantation of P. tomentosa as government of Nepal does not formulate necessary national policies, legislations and regulatory frameworks in its favor. Thus, system should be developed to set royalty rate of P. tomentosa recognizing its lifetime value.Int J Appl Sci Biotechnol, Vol 4(2): 155-160</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112064"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112064"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112064; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112064]").text(description); $(".js-view-count[data-work-id=43112064]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112064; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112064']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="43112063"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112063/Evaluation_of_Antibacterial_Activity_of_Some_Traditionally_Used_Medicinal_Plants_against_Human_Pathogenic_Bacteria"><img alt="Research paper thumbnail of Evaluation of Antibacterial Activity of Some Traditionally Used Medicinal Plants against Human Pathogenic Bacteria" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112063/Evaluation_of_Antibacterial_Activity_of_Some_Traditionally_Used_Medicinal_Plants_against_Human_Pathogenic_Bacteria">Evaluation of Antibacterial Activity of Some Traditionally Used Medicinal Plants against Human Pathogenic Bacteria</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The worldwide increase of multidrug resistance in both community- and health-care associated bact...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. We aimed to find the in vitro antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of Nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method. The evaluated plants species were found to exert a range of in vitro growth inhibitory action against the tested bacterial species, and Cynodon dactylon was found to exhibit moderate inhibitory action against 13 bacterial species including methicillin-resistant Staphylococcus aureus , imipenem-resistant Pseudomonas aeruginosa , multidrug-resistant Salmonella typhi , and S. typhimurium . The minimum inhibitory concentration (MIC) values of tested ethanolic extracts were found from 31 to >25,000 $\mu$ g/mL. Notably, ethanolic extracts of Cinnamomum camphora, Curculigo orchioides , and Curcuma longa exhibited the highest antibacterial activity against S. pyogenes with a MIC of 49, 49, and 195 $\mu$ g/mL, respectively; whereas chloroform fraction of Cynodon dactylon exhibited best antibacterial activity against S. aureus with a MIC of 31 $\mu$ g/mL. Among all, C. dactylon, C. camphora, C. orchioides , and C. longa plant extracts displayed a potential antibacterial activity of MIC <100 $\mu$ g/mL.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112063"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112063"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112063; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112063]").text(description); $(".js-view-count[data-work-id=43112063]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112063; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112063']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112063]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112063,"title":"Evaluation of Antibacterial Activity of Some Traditionally Used Medicinal Plants against Human Pathogenic Bacteria","internal_url":"https://www.academia.edu/43112063/Evaluation_of_Antibacterial_Activity_of_Some_Traditionally_Used_Medicinal_Plants_against_Human_Pathogenic_Bacteria","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112062"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112062/Early_onset_Alzheimer_s_Disease_and_its_Pathogenesis"><img alt="Research paper thumbnail of Early onset Alzheimer 's Disease and its Pathogenesis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112062/Early_onset_Alzheimer_s_Disease_and_its_Pathogenesis">Early onset Alzheimer 's Disease and its Pathogenesis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prevalence of Alzheimer's disease (AD) is signifi cantly high in developed countries where life e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prevalence of Alzheimer's disease (AD) is signifi cantly high in developed countries where life expectancy is relatively higher and its incidence is expected to increase over years. Etiology of this disease is complex; however, in a subtype called Early Onset Alzheimer's Disease (EOAD) which manifests at age below 65 years, genes are the sole cause — mutations in APP, PSEN1 and PSEN2 genes. Currently, there is no effective cure for AD. Therefore, a thorough understanding of pathogenesis of AD is crucial for designing drug-development studies. However, our knowledge is only in the growing phase in this fi eld. This paper briefl y reviews the pathogenesis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112062"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112062"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112062; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112062]").text(description); $(".js-view-count[data-work-id=43112062]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112062; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112062']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112062]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112062,"title":"Early onset Alzheimer 's Disease and its Pathogenesis","internal_url":"https://www.academia.edu/43112062/Early_onset_Alzheimer_s_Disease_and_its_Pathogenesis","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112061"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112061/NextGenVoices"><img alt="Research paper thumbnail of NextGenVoices" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112061/NextGenVoices">NextGenVoices</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112061"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112061"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112061; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112061]").text(description); $(".js-view-count[data-work-id=43112061]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112061; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112061']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112061]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112061,"title":"NextGenVoices","internal_url":"https://www.academia.edu/43112061/NextGenVoices","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112060"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112060/Clinical_and_microbiological_observational_study_on_AmpC_lactamase_producing_Enterobacteriaceae_in_a_hospital_of_Nepal"><img alt="Research paper thumbnail of Clinical and microbiological observational study on AmpC ?-lactamase-producing Enterobacteriaceae in a hospital of Nepal" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112060/Clinical_and_microbiological_observational_study_on_AmpC_lactamase_producing_Enterobacteriaceae_in_a_hospital_of_Nepal">Clinical and microbiological observational study on AmpC ?-lactamase-producing Enterobacteriaceae in a hospital of Nepal</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112060"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112060"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112060; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112060]").text(description); $(".js-view-count[data-work-id=43112060]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43112060; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43112060']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=43112060]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43112060,"title":"Clinical and microbiological observational study on AmpC ?-lactamase-producing Enterobacteriaceae in a hospital of Nepal","internal_url":"https://www.academia.edu/43112060/Clinical_and_microbiological_observational_study_on_AmpC_lactamase_producing_Enterobacteriaceae_in_a_hospital_of_Nepal","owner_id":158582682,"coauthors_can_edit":true,"owner":{"id":158582682,"first_name":"Bishnu","middle_initials":"P","last_name":"Marasini","page_name":"BishnuMarasini","domain_name":"cpds-tu","created_at":"2020-05-19T19:09:14.591-07:00","display_name":"Bishnu P Marasini","url":"https://cpds-tu.academia.edu/BishnuMarasini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43112059"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/43112059/High_prevalence_of_multidrug_resistance_in_bacterial_uropathogens_from_Kathmandu_Nepal"><img alt="Research paper thumbnail of High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal." class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/43112059/High_prevalence_of_multidrug_resistance_in_bacterial_uropathogens_from_Kathmandu_Nepal">High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal.</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT: Background: Urinary Tract Infection (UTI) is one of the most common infectious diseases...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT: Background: Urinary Tract Infection (UTI) is one of the most common infectious diseases and people of all age- groups and geographical locations are affected. The impact of disease is even worst in low-resource developing countries due to unaware of the UTIs caused by multidrug-resistant (MDR) pathogens and the possibility of transfer of MDR traits between them. The present study aimed to determine the prevalence of MDR bacterial isolates from UTI patients, the antibiotic resistance pattern and the conjugational transfer of multidrug resistance phenotypes in Escherichia coli (E. coli). Results: Two hundred and nineteen bacterial isolates were recovered from 710 urine samples at Kathmandu Model hospital during the study period. All samples and isolates were investigated by standard laboratory procedures. Among the significant bacterial growth (30.8%, 219 isolates), 41.1% isolates were MDR. The most prevailing organism, E. coli (81.3%, 178 isolates) was 38.2% MDR, whereas second most common organism, Citrobacter spp. (5%, 11 isolates) was found 72.7% MDR. Extended-spectrum b-lactamase (ESBL) production was detected in 55.2% of a subset of MDR E. coli isolates. Among the 29 MDR E. coli isolates, plasmids of size ranging 2-51 kb were obtained with different 15 profiles. The most common plasmid of size 32 kb was detected in all of the plasmid-harbored E. coli strains. The majority of E. coli isolates investigated for the multidrug resistance transfer were able to transfer plasmid-mediated MDR phenotypes along with ESBL pattern with a frequency ranging from 0.3 × 10-7 to 1.5 × 10-7 to an E. coli HB101 recipient strain by conjugation. Most of the donor and recipient strain showed high levels of minimum inhibitory concentration (MIC) values for commonly-used antibiotics. Conclusions: The high prevalence of multidrug resistance in bacterial uropathogens was observed. Particularly, resistance patterns were alarmingly higher for amoxycillin, co-trimoxazole, flouroquinolones and third-generation cephalosporins, which necessitate the re-evaluation of first and second line therapies for UTI. In addition, conjugational co-transfer of MDR phenotypes with ESBL-positive phenotypes was observed in MDR E. coli.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43112059"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43112059"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43112059; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43112059]").text(description); 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