CINXE.COM

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My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. We aim to understand the most basic principles of these receptors in order to develop new medications that are" /> <link rel="canonical" href="https://pharmacy.ucsf.edu/aashish-manglik" /> <meta property="og:site_name" content="UCSF School of Pharmacy" /> <meta property="og:type" content="website" /> <meta property="og:title" content="Aashish Manglik, MD, PhD · Associate Professor" /> <meta property="og:url" content="https://pharmacy.ucsf.edu/aashish-manglik" /> <meta property="og:description" content="Department of Pharmaceutical Chemistry · I am a physician-scientist interested in understanding how the human body senses and responds to external stimuli. My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. 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views-field-field-person-primary-dept"> <div class="field-content"><a href="http://pharmchem.ucsf.edu/">Department of Pharmaceutical Chemistry</a></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="moscone-container moscone-column-content clearfix"> <div class="moscone-column-content-region moscone-sidebar panel-panel"> <div class="moscone-column-content-region-inner moscone-sidebar-inner panel-panel-inner"> <div class="panel-pane pane-entity-field pane-node-field-person-headshot-photo" > <div class="pane-content"> <div class="field field-name-field-person-headshot-photo field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><div id="file-38681" class="file file-image file-image-jpeg file-entity-square-third file-entity-element-container"> <div class="content"> <picture >  <source srcset="/sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_third/public/person/photo/manglik-1x1_0.jpg?itok=yS-Qib4M&timestamp=1523050720 1x" 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src="/sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_third/public/person/photo/manglik-1x1_0.jpg?itok=yS-Qib4M&timestamp=1523050720" alt="Manglik" title="" /> </picture> </div> </div> </div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-person-email" > <div class="pane-content"> <div class="field field-name-field-person-email field-type-email field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/cdn-cgi/l/email-protection#50313123383923387e3d313e373c393b10253323367e353425"><span class="__cf_email__" data-cfemail="9ffefeecf7f6ecf7b1f2fef1f8f3f6f4dfeafcecf9b1fafbea">[email protected]</span></a></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-7" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_7 view-dom-id-b63a6ecb3b6a758fed92e79112d021eb"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-campus-phone"> <div class="field-content"></div> </div> <div class="views-field views-field-field-person-fax"> <div class="field-content"></div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-token pane-node-field-person-address-postal" > <div class="pane-content"> <div class="street-block"><div class="thoroughfare">1700 4th Street, Rm 508C</div></div> <div class="addressfield-container-inline locality-block country-US"><span class="locality">San Francisco</span>, <span class="state">CA</span> <span class="postal-code">94158</span></div> <span class="country">United States</span> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-12" > <h2 class="pane-title">Links</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_12 view-dom-id-053748d52ef333b9e9b67a89587dadda"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <span class="views-field views-field-field-person-links"> <span class="field-content"><a href="http://www.mangliklab.com" target="_blank">Manglik Lab</a></span> </span> <span class="views-field views-field-field-profiles-link"> <span class="field-content"><a href="https://profiles.ucsf.edu/aashish.manglik">UCSF Profiles</a></span> </span> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-24" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_24 view-dom-id-3b1079ff7cde504eccf41d5f23ede6df"> <div class="view-content"> <div> <h2>Affiliations</h2> </div> </div> <div class="view-footer"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_16 view-dom-id-ca770d5c8bd4fae3e100919075f37b5e"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_18 view-dom-id-3da5fdec66b6908ed519154c096d41cc"> <div class="view-header"> <h3>Education programs</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> Director, <a href="https://biophysics.ucsf.edu/">Biophysics Graduate Program (BP)</a> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_19 view-dom-id-409451849e3cbfc02768c58aa5e82b2b"> <div class="view-header"> <h3>UCSF centers, institutes, and research programs</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> <a href="https://qbi.ucsf.edu/">Quantitative Biosciences Institute (QBI)</a> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_20 view-dom-id-d2c119f93dd9c3efaab468a1508604c9"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_21 view-dom-id-403bf69f5f6cedc78a9b81baec27f7fa"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_22 view-dom-id-8fc54ed73597d8233b57874eb50a6472"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_23 view-dom-id-53a6d028d2373e016b95418fd59c63be"> </div> </div> </div> </div> </div> </div> </div> <div class="moscone-column-content-region moscone-content panel-panel"> <div class="moscone-column-content-region-inner moscone-content-inner panel-panel-inner"> <div class="panel-pane pane-entity-field pane-node-field-person-what-i-do-text" > <h2 class="pane-title">What I do</h2> <div class="pane-content"> <div class="field field-name-field-person-what-i-do-text field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>I am a physician-scientist interested in understanding how the human body senses and responds to external stimuli. My research focuses on the largest group of drug targets in the human body, the G protein coupled receptors. We aim to understand the most basic principles of these receptors in order to develop new medications that are both more effective and have decreased side effects.</p></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-8 pane-float-left-fifty-departmental-research-area pane-float-left-fifty" > <h2 class="pane-title">Departmental research area</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_8 view-dom-id-371138a670aae991c9ab989866a27083"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first"> <div class="views-field views-field-field-research-area"> <div class="field-content"><a href="https://pharmchem.ucsf.edu/research/chembio">chemical biology and medicinal chemistry</a></div> </div> </div> <div class="views-row views-row-2 views-row-even views-row-last"> <div class="views-field views-field-field-research-area"> <div class="field-content"><a href="https://pharmchem.ucsf.edu/research/procell">protein and cellular engineering</a></div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-token pane-node-field-person-dept-expertise-spec pane-float-left-fifty-my-research-expertise pane-float-left-fifty" > <h2 class="pane-title">My research expertise</h2> <div class="pane-content"> G-protein-coupled receptors (GPCRs), structural biology, signaling, protein dynamics </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-14" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_14 view-dom-id-9fd18f0487527c61bac5c4182be08b61"> <div class="view-content"> <div> <h2>Professional background</h2> </div> </div> <div class="view-footer"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_2 view-dom-id-cac185a2e9ef721713238e9ff0e096b5"> <div class="view-header"> <h3>Degrees</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> MD, Medicine, Stanford University School of Medicine, <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2016-01-01T00:00:00-08:00">2016</span> </div> <div class="views-row views-row-2"> PhD, Biophysics, Stanford University, <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2014-01-01T00:00:00-08:00">2014</span> </div> <div class="views-row views-row-3"> BA, Chemistry and Biology, Washington University, <span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2008-01-01T00:00:00-08:00">2008</span> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_13 view-dom-id-5d8464be77906f209c7343e0081bec56"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_15 view-dom-id-fbf3000fe4b7d0fbe0ba3a50e2112ea4"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_17 view-dom-id-80cea441bc141653307eac641dc1f885"> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-person-research-biography" > <h2 class="pane-title">Biography</h2> <div class="pane-content"> <div class="field field-name-field-person-research-biography field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Our laboratory seeks to understand how cells sense and respond to their external environment. In this endeavor, we study the numerous proteins that lie at the cellular surface that enable individual cells to decipher the enormous number of stimuli that coordinate normal physiology. To gain a fundamental understanding of such transmembrane signaling processes, we use a diverse array of techniques spanning biochemical and biophysical interrogation to protein engineering. Our ultimate goal is to use these insights to discover new approaches to precisely control cellular signaling.</p> </div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-9" > <h2 class="pane-title">Research keywords</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_9 columns-3 view-dom-id-0eb8c177cac43726243ccd1fcbbfe472"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-person-keywords-profiles"> <div class="field-content"><div class="item-list"><ul><li class="first">G protein-coupled receptor</li> <li>GPCR</li> <li>opioid receptors</li> <li>signaling</li> <li>structural biology</li> <li>protein biophysic</li> <li>Receptors, G-Protein-Coupled</li> <li>Signal Transduction</li> <li>beta-Arrestins</li> <li>Receptors, Adrenergic, beta-2</li> <li>Single-Domain Antibodies</li> <li>Receptors, Odorant</li> <li>Propionates</li> <li>GTP-Binding Proteins</li> <li>Receptors, Thyrotropin</li> <li>Receptors, Opioid, mu</li> <li>Hedgehog Proteins</li> <li>Smoothened Receptor</li> <li>Immunoglobulins, Thyroid-Stimulating</li> <li>Cryoelectron Microscopy</li> <li class="last">Sterols</li> </ul></div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="moscone-container moscone-footer clearfix panel-panel"> <div class="moscone-container-inner moscone-footer-inner panel-panel-inner"> <div class="panel-pane pane-block pane-quicktabs-quicktabs-pub-news-media" > <div class="pane-content"> <div id="quicktabs-quicktabs_pub_news_media" class="quicktabs-wrapper quicktabs-style-nostyle"><div class="item-list"><ul class="quicktabs-tabs quicktabs-style-nostyle"><li class="active first"><a href="/aashish-manglik?qt-quicktabs_pub_news_media=0#qt-quicktabs_pub_news_media" id="quicktabs-tab-quicktabs_pub_news_media-0" class="quicktabs-tab quicktabs-tab-view quicktabs-tab-view-person-related-items-panel-pane-1 active">News</a></li> <li class="last"><a href="/aashish-manglik?qt-quicktabs_pub_news_media=2#qt-quicktabs_pub_news_media" id="quicktabs-tab-quicktabs_pub_news_media-2" class="quicktabs-tab quicktabs-tab-view quicktabs-tab-view-ucsf-person-profile-panel-pane-4 active">Honors & Awards</a></li> </ul></div><div id="quicktabs-container-quicktabs_pub_news_media" class="quicktabs_main quicktabs-style-nostyle"><div id="quicktabs-tabpage-quicktabs_pub_news_media-0" class="quicktabs-tabpage "><div class="view view-person-related-items view-id-person_related_items view-display-id-panel_pane_1 view-dom-id-106aac51a08aed92f4cd99ea6dd6a91a"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-counter"> 1. </td> <td class="views-field views-field-title"> <a href="/news/2024/08/manglik-shares-passion-cellular-communication-ucsf-byers-award-lecture">Manglik shares passion for cellular communication in UCSF Byers Award Lecture</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 2. </td> <td class="views-field views-field-title"> <a href="/news/2024/03/manglik-awarded-2024-bowes-biomedical-investigator">Manglik awarded 2024 Bowes Biomedical Investigator</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 3. </td> <td class="views-field views-field-title"> <a href="/news/2023/12/school-pharmacy-faculty-recognized-among-highly-cited-researchers">School of Pharmacy faculty recognized among Highly Cited Researchers</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 4. </td> <td class="views-field views-field-title"> <a href="/news/2023/09/update-dean-putting-plans-action">Update from the Dean: Putting plans in action</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 5. </td> <td class="views-field views-field-title"> <a href="/news/2023/03/making-sense-scents">Making sense of scents</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 6. </td> <td class="views-field views-field-title"> <a href="/news/2023/02/manglik-arkin-bastian-receive-mark-foundation-aspire-award-moonshot-cancer-research">Manglik, Arkin, Bastian receive Mark Foundation ASPIRE Award for moonshot cancer research</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 7. </td> <td class="views-field views-field-title"> <a href="/news/2023/02/closing-equity-gap-science">Closing the equity gap in science</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 8. </td> <td class="views-field views-field-title"> <a href="/news/2022/12/update-dean-ongoing-excellence-new-frontiers">Update from the Dean: Ongoing excellence and new frontiers</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 9. </td> <td class="views-field views-field-title"> <a href="/news/2022/12/giacomini-krogan-shoichet-manglik-recognized-among-most-influential-scientists">Giacomini, Krogan, Shoichet, and Manglik recognized among most influential scientists</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 10. </td> <td class="views-field views-field-title"> <a href="/news/2022/10/unlocking-secrets-graves-disease">Unlocking the secrets of Graves’ disease</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 11. </td> <td class="views-field views-field-title"> <a href="/news/2022/05/update-dean-passing-torch">Update from the Dean: Passing the torch</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 12. </td> <td class="views-field views-field-title"> <a href="/news/2022/01/faculty-members-inducted-chan-zuckerberg-biohub-investigator-program">Faculty members inducted into the Chan Zuckerberg Biohub Investigator Program</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 13. </td> <td class="views-field views-field-title"> <a href="/news/2021/10/creating-healthy-inclusive-spaces-equity-inclusion-speaker-series">Creating Healthy and Inclusive Spaces – Equity and Inclusion Speaker Series</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 14. </td> <td class="views-field views-field-title"> <a href="/news/2021/03/update-dean-recovery-resilience-after-pandemic-year">Update from the Dean: Recovery and resilience after a pandemic year</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 15. </td> <td class="views-field views-field-title"> <a href="/news/2020/08/aeronabs-promise-powerful-inhalable-protection-against-covid-19">‘AeroNabs’ promise powerful, inhalable protection against COVID-19</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 16. </td> <td class="views-field views-field-title"> <a href="/news/2020/08/nanobody-based-antiviral-developed-ucsf-effectively-blocks-sars-cov-2-lab">Nanobody-based antiviral developed at UCSF effectively blocks SARS-CoV-2 in the lab</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 17. </td> <td class="views-field views-field-title"> <a href="/news/2019/11/update-dean-november-2019">Update from the Dean – November 2019</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 18. </td> <td class="views-field views-field-title"> <a href="/news/2018/07/update-dean-july-2018">Update from the Dean – July 2018</a> </td> </tr> <tr class="odd views-row-last"> <td class="views-field views-field-counter"> 19. </td> <td class="views-field views-field-title"> <a href="/news/2018/03/update-dean-march-2018">Update from the Dean – March 2018</a> </td> </tr> </tbody> </table> </div> </div></div><div id="quicktabs-tabpage-quicktabs_pub_news_media-2" class="quicktabs-tabpage quicktabs-hide"><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_4 view-dom-id-f1dc0c6980f9395aaec66ea6a71eafe3"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-counter"> 1. </td> <td class="views-field views-field-field-profiles-honors-awards"> Bowes Biomedical Investigator, UCSF, 2024 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 2. </td> <td class="views-field views-field-field-profiles-honors-awards"> Byers Award Lecture in Basic Science, UCSF, 2024 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 3. </td> <td class="views-field views-field-field-profiles-honors-awards"> Young Investigator Award, Amgen, 2022 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 4. </td> <td class="views-field views-field-field-profiles-honors-awards"> Young Investigator Award, International Narcotics Research Conference, 2017 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 5. </td> <td class="views-field views-field-field-profiles-honors-awards"> Director's Early Independence Award, National Institutes of Health, 2016-2021 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 6. </td> <td class="views-field views-field-field-profiles-honors-awards"> 30 under 30, Scientific American, 2013 </td> </tr> <tr class="odd views-row-last"> <td class="views-field views-field-counter"> 7. </td> <td class="views-field views-field-field-profiles-honors-awards"> Spector Award, Washington University in St. Louis, 2008 </td> </tr> </tbody> </table> </div> </div></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-1" > <h2 class="pane-title">Publications</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_1 view-dom-id-fe56bedef00a7ebe5945235d7ee87958"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-field-person-publications-list"> Li J, Inoue A, Manglik A, von Zastrow M. Role of the GRK2/3 N-terminus in discriminating the endocytic effects of opioid agonist drugs. Mol Pharmacol. 2024 Nov 06. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> de March CA, Ma N, Billesbølle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. Engineered odorant receptors illuminate the basis of odour discrimination. Nature. 2024 Oct 30. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Structural basis of μ-opioid receptor targeting by a nanobody antagonist. Nat Commun. 2024 Oct 09; 15(1):8687. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Howard MK, Hoppe N, Huang XP, Macdonald CB, Mehrota E, Grimes PR, Zahm A, Trinidad DD, English J, Coyote-Maestas W, Manglik A. Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv. 2024 Apr 18. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nat Struct Mol Biol. 2024 Apr; 31(4):667-677. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Yu J, Kumar A, Zhang X, Martin C, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist. bioRxiv. 2023 Dec 07. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> de March CA, Ma N, Billesbølle CB, Tewari J, Del Torrent CL, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. Engineered odorant receptors illuminate structural principles of odor discrimination. bioRxiv. 2023 Nov 17. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chung DH, Kong S, Young NJ, Chuo SW, Shiah JV, Connelly EJ, Rohweder PJ, Born A, Manglik A, Grandis JR, Johnson DE, Craik CS. Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets. Commun Biol. 2023 10 12; 6(1):1036. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G. Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell. 2023 05 11; 186(10):2160-2175.e17. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Billesbølle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A. Structural basis of odorant recognition by a human odorant receptor. Nature. 2023 03; 615(7953):742-749. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Barsi-Rhyne B, Manglik A, von Zastrow M. Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling. Elife. 2022 10 17; 11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 09; 609(7928):846-853. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y. Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun. 2022 07 28; 13(1):4366. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Deshpande I, Manglik A. Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody. Methods Mol Biol. 2022; 2374:149-160. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat Chem Biol. 2022 01; 18(1):109-115. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. 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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly E, Young NJ, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell. 2021 06 10; 184(12):3192-3204.e16. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS. Protein design and variant prediction using autoregressive generative models. Nat Commun. 2021 04 23; 12(1):2403. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, Hüttenhain R, Manglik A, Myers BR. Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 04; 19(4):e3001191. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Cancer Discov. 2021 08; 11(8):2032-2049. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. 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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 10; 586(7831):807-811. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. bioRxiv. 2020 Aug 17. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B. Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community. medRxiv. 2020 Aug 17. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Author Correction: Structural insights into μ-opioid receptor activation. 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Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 2020 02 25; 9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Manglik A. Molecular Basis of Opioid Action: From Structures to New Leads. Biol Psychiatry. 2020 01 01; 87(1):6-14. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 07; 571(7764):284-288. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun. 2018 09 13; 9(1):3712. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 2018 06 22; 7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. Structure of the µ-opioid receptor-Gi protein complex. Nature. 2018 06; 558(7711):547-552. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06 06; 98(5):963-976.e5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3834-3839. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol. 2018 03; 25(3):289-296. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Kruse AC. Structural Basis for G Protein-Coupled Receptor Activation. Biochemistry. 2017 10 24; 56(42):5628-5634. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Kobilka BK, Steyaert J. Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:19-37. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 09 08; 537(7619):185-190. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. 2016 07 21; 535(7612):448-52. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. Crystal structure of the human σ1 receptor. Nature. 2016 Apr 28; 532(7600):527-30. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kathryn E Livingston, Jacob Mahoney, Aashish Manglik, Brian Kobilka, Roger Sunahara, John R Traynor. Efficacy at the Mu Opioid Receptor: Insights from Orthosteric and Allosteric Ligands. The FASEB Journal. 2016 Apr 1; 30(S1). </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jacob Mahoney, Brian DeVree, Gisselle Velez-Ruiz, Soren Rasmussen, Adam Kuszak, Elin Edwald, Aashish Manglik, Matthieu Masureel, Yang Du, Rachel Matt, Els Pardon, Jan Steyaert, Brian Kobilka, Roger Sunahara. Structural Basis for Allosteric Coupling Between G Protein and the Agonist-Binding Pocket in GPCRs. The FASEB Journal. 2016 Apr 1; 30(S1). </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sydney R. Gordon, Roy Maute, Aaron Mayer, Melissa McCracken, Arutselvan Natarajan, Nan Guo, Richard Kimura, Jonathan M. Tsai, Aashish Manglik, Andrew Kruse, Sanjiv Gambhir, Irving L. Weissman, Aaron M. Ring. Abstract B101: Engineered PD-1 variants as immunotherapies for cancer. Imaging and Targeting of the Antitumor Response. 2016 Jan 1; b101-b101. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6506-14. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Aashish Manglik, Tae Hun Kim, Matthieu Masureel, Christian Altenbach, Zhongyu Yang, Daniel Hilger, Michael T. Lerch, Tong Sun Kobilka, Foon Sun Thian, Wayne L. Hubbell, R. Scott Prosser, Brian K. Kobilka. Structural Insights into the Dynamic Process of ß2-Adrenergic Receptor Signaling. Cell. 2015 Sep 1; 162(6):1431. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Propagation of conformational changes during μ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):375-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Structural insights into µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):315-21. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. 2015 May 21; 161(5):1101-1111. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS. A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins. J Biomol NMR. 2015 May; 62(1):97-103. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem. 2015 Apr 24; 290(17):10775-90. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17122-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10744-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Kobilka B. The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin. Curr Opin Cell Biol. 2014 Apr; 27:136-43. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 05; 504(7478):101-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kruse AC, Manglik A, Kobilka BK, Weis WI. Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr. 2013 Nov; 69(Pt 11):2287-92. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 2013 Oct 24; 502(7472):575-579. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc. 2013 Jun 26; 135(25):9465-74. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. Corrigendum: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chemistry - A European Journal. 2013 Apr 15; 19(16):4964-4964. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Arun K. Shukla, Aashish Manglik, Andrew Kruse, Rosana Reis, Wei Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, LiYin Huang, Marcin Peduch, Prachi Tripathi-Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony K. Kossiakoff, Brian K. Kobilka, Robert J. Lefkowitz. Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor. The FASEB Journal. 2013 Apr 1; 27:lb549-lb549. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. The dynamic process of β(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem. 2012 Oct 19; 287(43):36305-11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Pil Seok Chae, Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Ulrik Gether, Lan Guan, Claus J. Loland, Bernadette Byrne, Brian K. Kobilka, Samuel H. Gellman. Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012). Chemistry - A European Journal. 2012 Jul 27; 18(31):9434-9434. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry. 2012 Jul 27; 18(31):9485-90. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. Structure of the δ-opioid receptor bound to naltrindole. Nature. 2012 May 16; 485(7398):400-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6. </td> </tr> <tr class="even views-row-last"> <td class="views-field views-field-field-person-publications-list"> Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33. </td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div>  </div>  </div>  </div>  </div>  <div role="complementary" class="footer-make-a-gift-and-quote"> <div class="footer-make-a-gift"> <a href="https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_GeneralGivingForm&Primary=Pharmacy">Make a gift</a> </div> <div class="footer-quote"> Science is the foundation of the School of Pharmacy’s pioneering research, individualized patient care, and unparalleled PharmD and PhD education programs. </div> </div> <div class="footer-wrapper-outer" role="contentinfo"> <div class="footer-wrapper-inner"> <div class="footer-site-names-and-disclaimer"> </div> <div class="footer menu"> <ul id="footer-menu" class="links clearfix footer-menu"><li class="0 first"><a href="https://pharmacy.ucsf.edu/suggestions" title="">Suggestions</a></li> <li class="1"><a href="https://pharmacy.ucsf.edu/support?reporturl=https%3A//pharmacy.ucsf.edu/aashish-manglik" title="">Report a problem</a></li> <li class="menu-18196"><a href="/about/contact" title="">Contact us</a></li> <li class="menu-91601"><a href="https://websites.ucsf.edu/digital-accessibility" title="">Accessibility</a></li> <li class="menu-91606"><a href="https://www.ucsf.edu/website-privacy-policy" title="">Privacy policy</a></li> <li class="menu-91611"><a href="https://websites.ucsf.edu/website-terms-use" title="">Terms of use</a></li> <li class="menu-91616"><a href="https://websites.ucsf.edu/azlist" title="">A-Z website list</a></li> <li class="menu-7861 last"><a href="/saml_login?destination=aashish-manglik" title="" rel="nofollow">Log in</a></li> </ul> </div> <div class="footer-social"> <div class="item-list"><ul><li class="first"><a href="https://www.facebook.com/ucsfpharmacy" class="facebook">Facebook</a></li> <li><a href="https://www.youtube.com/@ucsfpharmacy" class="youtube">YouTube</a></li> <li><a href="https://www.linkedin.com/showcase/ucsf-school-of-pharmacy" class="linkedin">LinkedIn</a></li> <li><a href="https://x.com/ucsfpharmacy" class="twitter">X</a></li> <li class="last"><a href="https://www.instagram.com/ucsfpharmacy/" class="instagram">Instagram</a></li> </ul></div> </div> <div class="copyright"> © 2002–2024 The Regents of the University of California </div> </div> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript" src="/sites/pharmacy.ucsf.edu/files/advagg_js/js__GM3GJPR36rRIz0TRkjC5OQwrioSyN9aoYRivDhCO_AM__qAl84FcCv2jyN22yFGS5Oc85cjd9zKX6p_cFNLGhe-M__seqvHfaz3fVlgbfb4sGxYkGyco2BfGnhCPlf7TXVcuY.js" async="async"></script> <script type="text/javascript" src="/sites/pharmacy.ucsf.edu/files/advagg_js/js__BXT3KPF6ph4oEqAPjWiNmzlSjlQ9cW6B36GuZ8Knzt8__kNEvQrCieBaWSkG2Yi7cvf5o5n825wJD1XixHxWBUFo__seqvHfaz3fVlgbfb4sGxYkGyco2BfGnhCPlf7TXVcuY.js"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"3132ed34d6","applicationID":"70694569","transactionName":"YFRUNUpZDUdUUEddV1kedRRLTAxZGkNSU11oXFcPWV8GRmpdXFBdaEdfBE9nE1VSVhxBW0RXaRFdShBbWw==","queueTime":13,"applicationTime":785,"atts":"TBNXQwJDHkk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>