Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene

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The first region, located at -70, binds the ..."> <meta name="og:title" content="Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene"> <meta name="og:type" content="article"> <meta name="og:site_name" content="PubMed Central (PMC)"> <meta name="og:description" content="Two cis-acting sequences, recognized by two erythroid-specific trans-acting factors, are involved in the regulation of the erythroid promoter of the human gene coding for porphobilinogen deaminase (PBGD). 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name="pmc-banner-imagemap"><area alt="Link to Proceedings of the National Academy of Sciences of the United States of America" title="Link to Proceedings of the National Academy of Sciences of the United States of America" shape="default" href="https://doi.org/10.1073/pnas.86.17.6548" target="_blank" rel="noopener noreferrer"></map></section><article lang="en"><section aria-label="Article citation and metadata"><section class="pmc-layout__citation font-secondary font-xs"><div> <div class="display-inline-block"><button type="button" class="cursor-pointer text-no-underline bg-transparent border-0 padding-0 text-left margin-0 text-normal text-primary" aria-controls="journal_context_menu">Proc Natl Acad Sci U S A</button></div>. 1989 Sep;86(17):6548–6552. doi: <a href="https://doi.org/10.1073/pnas.86.17.6548" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">10.1073/pnas.86.17.6548</a> </div> <nav id="journal_context_menu" hidden="hidden"><ul class="menu-list font-family-ui" role="menu"> <li role="presentation"><a href="https://www.ncbi.nlm.nih.gov/pmc/?term=%22Proc%20Natl%20Acad%20Sci%20U%20S%20A%22%5Bjour%5D" class="usa-link" role="menuitem">Search in PMC</a></li> <li role="presentation"><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Proc%20Natl%20Acad%20Sci%20U%20S%20A%22%5Bjour%5D" lang="en" class="usa-link" role="menuitem">Search in PubMed</a></li> <li role="presentation"><a href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Proc%20Natl%20Acad%20Sci%20U%20S%20A%22%5BTitle%20Abbreviation%5D" class="usa-link" role="menuitem">View in NLM Catalog</a></li> <li role="presentation"><a href="?term=%22Proc%20Natl%20Acad%20Sci%20U%20S%20A%22%5Bjour%5D" class="usa-link" role="menuitem" data-add-to-search="true">Add to search</a></li> </ul></nav></section><section class="front-matter"><div class="ameta p font-secondary font-xs"> <hgroup><h1>Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.</h1></hgroup><div class="cg p"> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mignotte%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id1"><span class="name western">V Mignotte</span></a><div hidden="hidden" id="id1"> <h3><span class="name western">V Mignotte</span></h3> <div class="p"> <sup>1</sup>Institut National de la Santé et de la Recherche Médicale U.91, Hôpital Henri Mondor, Créteil, France.</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mignotte%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">V Mignotte</span></a> </div> </div> <sup>1</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Eleouet%20JF%22%5BAuthor%5D" class="usa-link" aria-describedby="id2"><span class="name western">J F Eleouet</span></a><div hidden="hidden" id="id2"> <h3><span class="name western">J F Eleouet</span></h3> <div class="p"> <sup>1</sup>Institut National de la Santé et de la Recherche Médicale U.91, Hôpital Henri Mondor, Créteil, France.</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Eleouet%20JF%22%5BAuthor%5D" class="usa-link"><span class="name western">J F Eleouet</span></a> </div> </div> <sup>1</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Raich%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id3"><span class="name western">N Raich</span></a><div hidden="hidden" id="id3"> <h3><span class="name western">N Raich</span></h3> <div class="p"> <sup>1</sup>Institut National de la Santé et de la Recherche Médicale U.91, Hôpital Henri Mondor, Créteil, France.</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Raich%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">N Raich</span></a> </div> </div> <sup>1</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Romeo%20PH%22%5BAuthor%5D" class="usa-link" aria-describedby="id4"><span class="name western">P H Romeo</span></a><div hidden="hidden" id="id4"> <h3><span class="name western">P H Romeo</span></h3> <div class="p"> <sup>1</sup>Institut National de la Santé et de la Recherche Médicale U.91, Hôpital Henri Mondor, Créteil, France.</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Romeo%20PH%22%5BAuthor%5D" class="usa-link"><span class="name western">P H Romeo</span></a> </div> </div> <sup>1</sup> </div> <ul class="d-buttons inline-list"> <li><button class="d-button" aria-controls="aip_a" aria-expanded="false">Author information</button></li> <li><button class="d-button" aria-controls="clp_a" aria-expanded="false">Copyright and License information</button></li> </ul> <div class="d-panels font-secondary-light"> <div id="aip_a" class="d-panel p" style="display: none"><div class="p" id="aff1"> <sup>1</sup>Institut National de la Santé et de la Recherche Médicale U.91, Hôpital Henri Mondor, Créteil, France.</div></div> <div id="clp_a" class="d-panel p" style="display: none"><div class="p"><a href="/about/copyright/" class="usa-link">PMC Copyright notice</a></div></div> </div> <div>PMCID: PMC297881 PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/2771941/" class="usa-link">2771941</a> </div> </div></section></section><section aria-label="Article content"><section class="body main-article-body"><section class="abstract" id="abstract1"><h2>Abstract</h2> <p>Two cis-acting sequences, recognized by two erythroid-specific trans-acting factors, are involved in the regulation of the erythroid promoter of the human gene coding for porphobilinogen deaminase (PBGD). The first region, located at -70, binds the erythroid factor NF-E1, and point mutations within this region abolish the induction of transcription of this promoter during murine erythroleukemia (MEL) cell differentiation. The second region, located at -160, binds the erythroid-specific factor NF-E2 and the ubiquitous factor AP1. Using UV cross-linking, we show that NF-E2 has a higher molecular weight than AP1, demonstrating that NF-E2 is not an erythroid-specific degradation product of AP1. By point mutagenesis of the NF-E2/AP1 binding site, we define mutations that abolish binding of either NF-E2 alone or AP1 and NF-E2 together. Regulation of transcription of the PBGD erythroid promoter is abolished by those mutations, suggesting that NF-E2 but not AP1 is necessary for correct regulation of this promoter in erythroid cells.</p></section><section id="supplementary-material1" class="scanned-pages"><div class="scanned-pages__header"> <h2>Full text</h2> <a href="/articles/instance/297881/pdf/pnas00284-0116.pdf" class="usa-button usa-button--unstyled display-flex flex-justify-center text-no-underline hover:text-no-underline width-auto"><svg class="usa-icon" aria-hidden="true" role="img"><use href="/static/img/sprite.svg#file_download"></use></svg><span>PDF</span></a> </div> <div class="grid-container padding-0 p"><div class="grid-row"><div class="grid-col-fill tablet:margin-right-2"><nav aria-label="Pagination" class="usa-pagination margin-0 tablet:flex-justify-start pmc-pagination__scanned" data-page-size="5" data-current-page="1"><ul class="usa-pagination__list usa-pagination__list--scanned"> <li 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Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene - PMC