CINXE.COM
KEGG ENZYME: 1.5.4.1
<!doctype html> <html><head> <title>KEGG ENZYME: 1.5.4.1</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1732783624"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1732783624"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1732783624" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } else{ obj.style.display = 'none'; clk.innerHTML = ' » '+show; } } } function toggleData(bobj,e){ var id = bobj.id.replace(/[^0-9]/g,''); var dt = document.getElementById('kcfd'+id); e.preventDefault(); if(!dt.style.display||dt.style.display == 'none'){ document.getElementById('kcfb'+id).innerHTML = 'Hide'; dt.style.display = 'block'; } else{ document.getElementById('kcfb'+id).innerHTML = 'Show'; dt.style.display = 'none'; } } function btn(bobj,img) { bobj.src = "/Fig/bget/button_" + img + ".gif"; } function btn_e(e) { e = e || event; var obj = e.target; var img = e.target.src; var img_base = img.replace(/\\/g,'/').replace(/(b|bd|bh)\.gif$/,''); if(e.type == 'mousedown'||e.type == 'touchstart'){ obj.src = img_base +'bd.gif'; } else if(e.type == 'mouseover'){ obj.src = img_base +'bh.gif'; } else if(e.type == 'mouseup'||e.type == 'touchend'){ obj.src = img_base +'b.gif'; } else if(e.type == 'mouseout'){ obj.src = img_base +'b.gif'; } } function init(){ for(var i=1;i<=1;i++){ if(document.getElementById('kcfb'+i)){ document.getElementById('kcfb'+i).onclick = function(e){toggleData(this,e);}; } } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="683"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td> </td><td><a name="enzyme:1.5.4.1"></a><font class="title2">ENZYME: 1.5.4.1</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_enzyme.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">EC 1.5.4.1 Enzyme <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">pyrimidodiazepine synthase;<br> PDA synthase;<br> pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);<br> pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td20 defd"><div class="cel">Oxidoreductases;<br> Acting on the CH-NH group of donors;<br> With a disulfide as acceptor<br> <button class="btn" onclick="location.href='/brite/ko01000+1.5.4.1';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Sysname</span></th> <td class="td21 defd"><div class="cel">2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reaction(IUBMB)</span></th> <td class="td20 defd"><div class="cel">2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN:<a href="/entry/R03984">R03984</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction(KEGG)</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/R03984">R03984</a><br> <button class="btn" onclick="location.href='/entry/R03984';return false;">Reaction</button></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Substrate</span></th> <td class="td20 defd"><div class="cel">2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD:<a href="/entry/C02587">C02587</a>];<br> glutathione disulfide [CPD:<a href="/entry/C00127">C00127</a>];<br> H2O [CPD:<a href="/entry/C00001">C00001</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td21 defd"><div class="cel"><div class="cel">6-pyruvoyltetrahydropterin [CPD:<a href="/entry/C03684">C03684</a>];<br> glutathione [CPD:<a href="/entry/C00051">C00051</a>]<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td20 defd"><div class="cel">In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">History</span></th> <td class="td21 defd"><div class="cel">EC 1.5.4.1 created 1990, modified 2014<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec00480+1.5.4.1">ec00480</a> </span></td><td>Glutathione metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec00790+1.5.4.1">ec00790</a> </span></td><td>Folate biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec01100+1.5.4.1">ec01100</a> </span></td><td>Metabolic pathways</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00310">K00310</a> </span></td><td>pyrimidodiazepine synthase</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td20 defd"><style>.g1{display:none;}</style><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DME+ec:1.5.4.1" target="_blank">DME</a>: </span></td><td>Dmel_CG6781(se)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DER+ec:1.5.4.1" target="_blank">DER</a>: </span></td><td>6545777</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DSE+ec:1.5.4.1" target="_blank">DSE</a>: </span></td><td>6604890</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DSI+ec:1.5.4.1" target="_blank">DSI</a>: </span></td><td>Dsimw501_GD14100(Dsim_GD14100)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DYA+ec:1.5.4.1" target="_blank">DYA</a>: </span></td><td>Dyak_GE20749</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DAN+ec:1.5.4.1" target="_blank">DAN</a>: </span></td><td>6506964</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DSR+ec:1.5.4.1" target="_blank">DSR</a>: </span></td><td>110189884</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DPO+ec:1.5.4.1" target="_blank">DPO</a>: </span></td><td>4813077</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DPE+ec:1.5.4.1" target="_blank">DPE</a>: </span></td><td>6601435</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DMN+ec:1.5.4.1" target="_blank">DMN</a>: </span></td><td>108151105</td></tr></table><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DWI+ec:1.5.4.1" target="_blank">DWI</a>: </span></td><td>6645945</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DMO+ec:1.5.4.1" target="_blank">DMO</a>: </span></td><td>Dmoj_GI11974</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DAZ+ec:1.5.4.1" target="_blank">DAZ</a>: </span></td><td>108613358</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DNV+ec:1.5.4.1" target="_blank">DNV</a>: </span></td><td>108650772</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DHE+ec:1.5.4.1" target="_blank">DHE</a>: </span></td><td>111601724</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+DVI+ec:1.5.4.1" target="_blank">DVI</a>: </span></td><td>6624546</td></tr></table></div><a href="javascript:void(0)" onclick="javascript:toggleField(this,"g1","show all","hide")"> » show all</a><br> <input type="hidden" name="query" form="form1" value="DME DER DSE DSI DYA DAN DSR DPO DPE DMN DWI DMO DAZ DNV DHE DVI"><input type="hidden" name="htext" form="form1" value="br08601.keg"><input type="hidden" name="option" form="form1" value="-a"><button class="btn" onclick="javascript:go_taxonomy(document.form1,{"action":"/kegg-bin/search_htext"});return false;">Taxonomy</button></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/6438092">6438092</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td20 repd"><div class="cel">Wiederrecht GJ, Brown GM.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td21 repd"><div class="cel">Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td20 repd"><div class="cel">J Biol Chem 259:14121-7 (1984)</div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">2 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16712527">16712527</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td20 repd"><div class="cel">Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td21 repd"><div class="cel">Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td20 repd"><div class="cel">Biochem J 398:451-60 (2006)<br>DOI:<a href="https://doi.org/10.1042/BJ20060424">10.1042/BJ20060424</a></div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td21 repd"><div class="cel">[dme:<a href="/entry/dme:Dmel_CG6781">Dmel_CG6781</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExplorEnz - The Enzyme Database: </span></td><td><a href="https://www.enzyme-database.org/query.php?ec=1.5.4.1">1.5.4.1</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">IUBMB Enzyme Nomenclature: </span></td><td><a href="https://iubmb.qmul.ac.uk/enzyme/EC1/5/4/1.html">1.5.4.1</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExPASy - ENZYME nomenclature database: </span></td><td><a href="https://enzyme.expasy.org/EC/1.5.4.1">1.5.4.1</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">BRENDA, the Enzyme Database: </span></td><td><a href="https://www.brenda-enzymes.info/enzyme.php?ecno=1.5.4.1">1.5.4.1</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>93586-06-2</td></tr></table></td></tr> <tr><th class="th21 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td21 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?enzyme+1.5.4.1';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>