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background-size:100%;"> <div class="angle angle_left angle_white">  </div>  </div>  </div> <div class="center"> <div class="section group content"> <div class="col span_1_of_1"> <h2><strong>Discovery of the best human therapeutic antibodies starts with AlivaMab Mouse. </strong></h2> <p>Ablexis’ AlivaMab Mouse is the only transgenic animal designed to enable and optimize the efficient discovery and development of the next generation of human therapeutic antibodies.</p> <p>The platform has been validated for antibody drug discovery by Ablexis and our partners for a range of applications including:</p> <ul> <li>Challenging targets such as GPCRs</li> <li>Challenging design goals such as very low picomolar IC<sub>50</sub> values</li> <li>Sequence diverse panels of mAbs</li> <li>Epitope diverse panels of mAbs</li> <li>AlivaMabs being developed in various formats including regular antibodies, bispecifics and CAR-Ts</li> </ul>  </div>  </div>  </div> <div class="section group section-header section-header-large animation-element lift"> <div class="section-header-content-wrap left"> <div class="align_center_left text_left text-wrap"> <div class="header-text"> <h5 class="sans">The AlivaMab Difference</h5> <h2 >A Better Design Delivers Unique Benefits</h2>  </div>  </div>  </div><div class="section-header-angle-wrap back_white left"> <div class="angle angle_left angle_gray">  </div>  </div>  </div> <div class="clear"></div> <div class="section group guttered content extended-content technology-feature"> <div class="feature-title full text_center"> <h2>Key Features and Benefits of the AlivaMab Mouse</h2>  </div> <div class="clear"></div> <div class="center"> <div class="col span_1_of_3"> <h3>Features</h3> <ul> <li>First and only synthetic, autonomously functioning heavy, kappa and lambda immunoglobulin transgenes</li> <li>Unique combinations of human and mouse coding and non-coding elements</li> <li>Diverse, curated repertoire of VH, Vκ and Vλ gene segments selected for developability and lowered risk of immunogenicity</li> <li>Patented human/mouse chimeric antibody composition</li> <li>Three AlivaMab Mouse strains: K-L with a Igκ/Igλ expression ratio as in humans, Kappa, and Lambda</li> </ul>  </div> <div class="col span_1_of_3"> <img src="https://www.ablexis.com/wp-content/uploads/2018/09/antibody_rework.jpg" />  </div> <div class="col span_1_of_3"> <h3>Benefits</h3> <ul> <li>Robust immune responses for efficient discovery of high-quality therapeutic lead candidates that meet potency, specificity, and developability requirements</li> <li>Real diversity in the V region repertoire in both the primary and secondary immune responses better than other transgenic platforms</li> <li>Retention of activity and developability qualities upon conversion to fully human</li> <li><span style="line-height: 1.5">Choices for AlivaMab Mouse strains allow for maximizing light chain diversity and pre-selecting for light chain composition</span></li> </ul>  </div>  </div>  </div> <div class="section group page-divider text_center" style="background:url('https://www.ablexis.com/wp-content/uploads/2018/09/ablexis_dna_web_crop3.jpg'); center center; background-repeat: no-repeat; background-size:cover; "> <div class="center"> <h5 class="sans">AlivaMab Mouse</h5> <h2>The superior platform for the discovery of therapeutic antibodies</h2>  </div>  </div> <div class="clear"></div> <div class="section group section-header section-header-large animation-element lift"> <div class="section-header-content-wrap left"> <div class="align_center_left text_left text-wrap"> <div class="header-text"> <h2 class="solo">Your Choice of Platform Matters</h2>  </div>  </div>  </div><div class="section-header-angle-wrap back_white left"> <div class="angle angle_left angle_gray">  </div>  </div>  </div> <div class="clear"></div> <div class="section group guttered content extended-content"> <div class="center"> <div class="col span_1_of_1"> <p>The past four decades have seen advances in therapeutic monoclonal antibody discovery technologies from fully mouse to fully human antibodies. Today, fully human antibodies are typically generated using two distinct approaches: (1) <em>in vitro</em> systems and (2) genetically-engineered animals.</p> <p>However, while humanization and <em>in vitro</em> techniques such as phage, ribosomal, yeast and mammalian display technologies appear simplistically attractive, there is a growing appreciation that downstream risks in development - problems that may not become apparent until after hundreds of millions of dollars have been spent - are amplified by in vitro technologies. Such risks include inadequate potency, CMC issues, off-target binding, and anti-drug antibody formation.</p> <p>In contrast to <em>in vitro</em> display and humanization technologies, transgenic mice can reduce the risk of expensive problems and failures in later stages of development through harnessing of the natural <em>in vivo </em>immune response to generate high-affinity, high-potency antibodies that inherently possess desirable qualities of developability, specificity, and reduced risk of immunogenicity. This combination of attributes helps explain why there are substantially more marketed fully human antibody drugs that were discovered using transgenic mice than from <em>in vitro</em> display platforms.</p> <p>Innovative technologies were used to create the specialized transgene designs for the AlivaMab Mouse platform, improving upon the limited bacterial artificial chromosome (BAC) and yeast artificial chromosome (YAC) genomic library approaches of other technologies.</p> <p>AlivaMab Mouse is the first transgenic animal to use synthetic immunoglobulin (Ig) transgenes, and the only one to use autonomously functioning synthetic Ig transgenes, avoiding the need to hijack the constant regions and <em>cis</em> regulatory elements of the endogenous Ig loci. By first designing the Ig transgenes of AlivaMab Mouse <em>in silico</em> and then synthesizing the DNAs <em>in vitro</em>, multiple aspects were optimized to help meet the challenges of both antibody drug discovery and antibody drug development. These aspects include function of the immunoglobulin transgenes, a thoughtfully curated endowment of VH, Vκ and Vλ gene segments, and a unique part-human/part-mouse composition of the antibody.</p> <p> </p> <p><a class="action" href="https://www.ablexis.com/contact/">LEARN MORE</a></p>  </div>  </div>  </div>  </div> <div class="clear"></div> <div id="footer" class="section group guttered_deep back_red"> <div class="center"> <div class="col span_1_of_2"> <div class="copy"> <p><span class="slab">Ablexis delivers a superior, next generation transgenic mouse platform for the discovery of therapeutic antibodies.</p>  </div> <a class="logo" href="https://www.ablexis.com"><img src="https://www.ablexis.com/wp-content/uploads/2018/08/ablexis_logo_white.png" /></a> <div class="clear"></div> <ul> <li>10350 Barnes Canyon Road, Suite 100</li> <li>San Diego, CA 92121</li> <li>415.967.1220</li> </ul> <a href="https://www.ablexis.com/privacy-policy/"class="page-link">Privacy Policy</a>  </div> <div 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